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Dementia and exercise

Tanuj Sharma, Mohammad Imran Siddiqi
Unique intrinsic properties of peptides like low toxicity, high biological activity and specificity make them attractive therapeutic agents. PDZ binding peptide inhibitors have been demonstrated for curing of Alzheimer, Parkinson, Dementia and other central nervous system ailments. In this article, we report the successful use of an integrated computational protocol to analyze the structural basis of how peptides bind to the shallow groove of the third PDZ domain (PDZ3) from the Post Synaptic Density (PSD-95) protein...
March 20, 2018: Journal of Biomolecular Structure & Dynamics
John R Best, Janice J Eng, Jennifer C Davis, Robin Hsiung, Peter A Hall, Laura E Middleton, Peter Graf, Charles H Goldsmith, Teresa Liu-Ambrose
INTRODUCTION: Cerebrovascular disease-such as stroke-is the second most common cause of dementia (ie, vascular dementia). Specifically, a stroke increases one's risk for dementia by a factor of two. Thus, stroke survivors represent a target population in need of intervention strategies to promote cognitive function and prevent dementia. The current standard of care in stroke rehabilitation does not adequately address the significant cognitive consequences of stroke, especially for those who are in the chronic phase (ie, >12 months since an index stroke)...
March 17, 2018: BMJ Open
Hwan-Hee Kim, Nam-Hae Jung
[Purpose] In this study, we investigated the effects of combining exercise with a cognitive-enhancement group program on cognition and depression in a group of community-dwelling elderly people. [Subjects and Methods] The study's subjects consisted of 30 community-dwelling elderly people of both genders, whose average age was 78 years. They participated in a program of physical exercise combined with a cognitive-enhancement group training program. This consisted of sessions lasting 60 minutes that took place once a week over 3 months...
February 2018: Journal of Physical Therapy Science
Hyun Jun Kim, Sang Yeoup Lee, Hwa Gyeong Lee, Yang Hee Cho, Eun Mi Ko
Few studies have been undertaken to develop cognitive functional improvement-focused exercise programs and determine their effect. The objectives of this study were to evaluate the effects of a cognitive enhancement fitness program (CEFP) on short-term memory and serum brain-derived neurotrophic factor (BDNF) levels according to the cognitive state in middle-aged women. A total of 30 healthy volunteers aged 40-59 years were divided into two groups, that is, a mild cognitive impairment (MCI) group and a non-MCI group based on results from the Korean Dementia Screening Questionnaire...
March 2018: Journal of Sports Science & Medicine
Franziska Nickel, Janina Barth, Peter L Kolominsky-Rabas
BACKGROUND: This systematic review aims to review the literature on trial-based economic evaluations of non-pharmacological interventions directly targeted at persons with dementia as well as persons with mild cognitive impairment and their respective caregivers. METHODS: A systematic literature research was conducted for the timeframe from 2010 to 2016 in the following databases: Centre for Reviews and Dissemination, EconLit, Embase, Cochrane Library, PsycINFO and PubMed...
March 9, 2018: BMC Geriatrics
Hiroaki Kazui
Previous systematic reviews of non-pharmacological interventions for clinical symptoms in dementia patients have confirmed the effectiveness of cognitive stimulation therapy (CST) for cognitive impairment, exercise therapy for activities of daily living, and music therapy and behavior management techniques for behavioral and psychological symptoms of dementia (BPSD). A Japanese version of CST has been developed and is available, but standardized exercise therapy and music therapy have not been developed. It is also important for informal and formal caregivers to learn behavior management techniques...
March 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
Musetta C Fu, Basia Belza, Huong Nguyen, Rebecca Logsdon, Steven Demorest
PURPOSE: Participating in a group-singing program may be beneficial to healthy aging through engaging in active music-making activities and breathing exercises. The purpose of this study was to assess the feasibility, acceptability, and impact of a 12-week group singing program on cognitive function, lung health and quality of life (QoL) of older adults. MATERIALS AND METHODS: A pre and post-test quasi-experimental design evaluated the impact of a group-singing program on older adult health...
February 23, 2018: Archives of Gerontology and Geriatrics
Lauren T Ptomey, Amanda N Szabo, Erik A Willis, Anna M Gorczyca, J Leon Greene, Jessica C Danon, Joseph E Donnelly
BACKGROUND: Between 250,000 and 400,000 individuals in the United States are diagnosed with Down syndrome (DS). Nearly all adults with DS will develop Alzheimer's disease pathology starting in their thirties. Recent studies suggest that increased physical activity (PA) may be important for maintaining components of cognition, including memory. OBJECTIVE: The purpose of this study was to evaluate changes in cognitive function after completion of a 12-week exercise intervention in adults with DS...
February 26, 2018: Disability and Health Journal
Abigail J Hall, Lisa Burrows, Iain A Lang, Ruth Endacott, Victoria A Goodwin
BACKGROUND: People with dementia may receive physiotherapy for a variety of reasons. This may be for musculoskeletal conditions or as a result of falls, fractures or mobility difficulties. While previous studies have sought to determine the effectiveness of physiotherapy interventions for people with dementia, little research has focused on the experiences of people receiving such treatment. The aim of this study was to gain an in-depth understanding of people's experiences of receiving physiotherapy and to explore these experiences in the context of principles of person-centred care...
March 2, 2018: BMC Geriatrics
Christine R Kovach, Crystal-Rae Evans, Lisa Sattell, Kimberly Rosenau, Sandeep Gopalakrishnan
Mindfulness interventions have been beneficial for healthy adults and individuals experiencing a stressful medical or mental health diagnosis. The purposes of the current study were to: (a) determine feasibility of mindfulness for older adults in long-term residential settings, and (b) examine differences in outcomes between a mindfulness and cognitive activity. The current study is the first mindfulness study to include individuals in moderate and severe stages of dementia, and included 36 individuals with a range of cognitive abilities...
March 1, 2018: Research in Gerontological Nursing
Sarah C McEwen, Prabha Siddarth, Berna Abedelsater, Yena Kim, Wenli Mui, Pauline Wu, Natacha D Emerson, Jacob Lee, Shayna Greenberg, Tiffany Shelton, Scott Kaiser, Gary W Small, David A Merrill
BACKGROUND: Several modifiable lifestyle factors have been shown to have potential beneficial effects in slowing cognitive decline. Two such factors that may affect cognitive performance and slow the progression of memory loss into dementia in older adults are cognitive training and physical activity. There are currently no effective treatments for dementia; therefore, preventative strategies to delay or prevent the onset of dementia are of critical importance. OBJECTIVE: The aim of this study was to determine the relative effectiveness of simultaneous performance of memory training and aerobic exercise to a sequential performance intervention on memory functioning in older adults...
2018: Journal of Alzheimer's Disease: JAD
Rowan H Harwood, Veronika van der Wardt, Sarah E Goldberg, Fiona Kearney, Pip Logan, Vicky Hood-Moore, Vicky Booth, Jennie E Hancox, Tahir Masud, Zoe Hoare, Andrew Brand, Rhiannon Tudor Edwards, Carys Jones, Roshan das Nair, Kristian Pollock, Maureen Godfrey, John R F Gladman, Kavita Vedhara, Helen Smith, Martin Orrell
Background: People with dementia progressively lose abilities and are prone to falling. Exercise- and activity-based interventions hold the prospect of increasing abilities, reducing falls, and slowing decline in cognition. Current falls prevention approaches are poorly suited to people with dementia, however, and are of uncertain effectiveness. We used multiple sources, and a co-production approach, to develop a new intervention, which we will evaluate in a feasibility randomised controlled trial (RCT), with embedded adherence, process and economic analyses...
2018: Pilot and Feasibility Studies
Jesse Russell-Williams, Wafa Jaroudi, Tania Perich, Siobhan Hoscheidt, Mohamad El Haj, Ahmed A Moustafa
This study investigates the relationship between mindfulness, meditation, cognition and stress in people with Alzheimer's disease (AD), dementia, mild cognitive impairment and subjective cognitive decline. Accordingly, we explore how the use of meditation as a behavioural intervention can reduce stress and enhance cognition, which in turn ameliorates some dementia symptoms. A narrative review of the literature was conducted with any studies using meditation as an intervention for dementia or dementia-related memory conditions meeting inclusion criteria...
February 21, 2018: Reviews in the Neurosciences
Kathryn Mullan, Chris R Cardwell, Bernadette McGuinness, Jayne V Woodside, Gareth J McKay
Serum antioxidants may afford neuroprotection against Alzheimer's disease (AD) via correction of the pro-oxidative imbalance but findings reported have been inconsistent. We compared the pooled mean difference in serum levels of ten dietary antioxidants between patients with AD and cognitively intact controls from 52 studies in meta-analyses using random-effects models. Patients with AD had significantly lower plasma levels of α-carotene, β-carotene, lycopene, lutein, vitamin A, C, and E, and uric acid. No significant difference was observed for plasma levels of β-cryptoxanthin and zeaxanthin...
2018: Journal of Alzheimer's Disease: JAD
Vicky Booth, Rowan H Harwood, Victoria Hood-Moore, Trevor Bramley, Jennie E Hancox, Kate Robertson, Judith Hall, Veronika Van Der Wardt, Pip A Logan
This series of articles for rehabilitation in practice aims to cover a knowledge element of the rehabilitation medicine curriculum. Nevertheless, they are intended to be of interest to a multidisciplinary audience. The competency addressed in this article is an understanding of how to develop an intervention for people with mild cognitive impairment and dementia to promote their independence, stability, and physical activity. INTRODUCTION: Older adults with dementia are at a high risk of falls...
February 1, 2018: Clinical Rehabilitation
Ashleigh E Smith, Ashlee M Hendy, Gavin D Tempest
The societal and economic costs of conditions associated with brain pathology (for example depression, dementia and stroke) are ever increasing. This article is protected by copyright. All rights reserved.
February 9, 2018: Journal of Physiology
Trista Askins Bailey, Sehrish Panjwani
As persons age, their risk of developing late-life depression increases. Older adults not only have an increased risk of late-life depression, but they also have an increased risk of suicidal ideation. Because of these increased risks, it is vital that clinicians be aware of the options available to assist these persons to achieve remission of their symptoms, as well as prevent relapse. Atypical antipsychotics have been considered an augmentation option in younger adults with depression. However, because of the black box warning associated with atypical antipsychotics in older adults with dementia, clinicians often exercise caution when using these agents to help treat late-life depression...
February 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Lisanne F Ten Brinke, John R Best, Rachel A Crockett, Teresa Liu-Ambrose
BACKGROUND: Given the world's aging population, it is important to identify strategies that promote healthy cognitive aging and minimize cognitive decline. Currently, no curative pharmaceutical therapy exists for cognitive impairment and dementia. As a result, there is much interest in lifestyle approaches. Specifically, complex mental activity, such as cognitive training, may be a promising method to combat cognitive decline in older adults. As such, the industry of commercial computerized cognitive training (CCT) applications has rapidly grown in the last decade...
January 30, 2018: BMC Geriatrics
Laura E Middleton, Sandra E Black, Nathan Herrmann, Paul I Oh, Kayla Regan, Krista L Lanctot
BACKGROUND: Worldwide, almost 50million people lived with dementia in 2016. A cure or disease modifying pharmaceutical treatment for dementia remains elusive so alternative therapies are of critical importance. Mounting evidence supports exercise in the prevention and therapy of dementia. However, the cognitive, physical, and psychological challenges common to dementia along with a poor understanding and accommodation of dementia in the community are major barriers to exercise. Consequently, effective delivery options need to be identified...
January 25, 2018: BMC Geriatrics
Alina Solomon, Heidi Turunen, Tiia Ngandu, Markku Peltonen, Esko Levälahti, Seppo Helisalmi, Riitta Antikainen, Lars Bäckman, Tuomo Hänninen, Antti Jula, Tiina Laatikainen, Jenni Lehtisalo, Jaana Lindström, Teemu Paajanen, Satu Pajala, Anna Stigsdotter-Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto
Importance: The role of the apolipoprotein E (APOE) ε4 allele as an effect modifier in lifestyle interventions to prevent cognitive impairment is still unclear. Objective: To examine whether the APOE ε4 allele modifies the previously reported significant cognitive benefits of a multidomain lifestyle intervention (prespecified subgroup analysis). Design, Setting, and Participants: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a randomized clinical trial in 6 centers across Finland (screening and randomization performed from September 7, 2009, through November 24, 2011; intervention duration, 2 years)...
January 22, 2018: JAMA Neurology
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