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Pulmonary aspergillosis

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https://www.readbyqxmd.com/read/28432297/high-probability-of-comorbidities-in-bronchial-asthma-in-germany
#1
S Heck, S Al-Shobash, D Rapp, D D Le, A Omlor, A Bekhit, M Flaig, B Al-Kadah, W Herian, R Bals, S Wagenpfeil, Q T Dinh
Clinical experience has shown that allergic and non-allergic respiratory, metabolic, mental, and cardiovascular disorders sometimes coexist with bronchial asthma. However, no study has been carried out that calculates the chance of manifestation of these disorders with bronchial asthma in Saarland and Rhineland-Palatinate, Germany. Using ICD10 diagnoses from health care institutions, the present study systematically analyzed the co-prevalence and odds ratios of comorbidities in the asthma population in Germany...
April 21, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28431569/co-colonisation-with-aspergillus-fumigatus-and-pseudomonas-aeruginosa-is-associated-with-poorer-health-in-cystic-fibrosis-patients-an-irish-registry-analysis
#2
Emma Reece, Ricardo Segurado, Abaigeal Jackson, Siobhán McClean, Julie Renwick, Peter Greally
BACKGROUND: Pulmonary infection is the main cause of death in cystic fibrosis (CF). Aspergillus fumigatus (AF) and Pseudomonas aeruginosa (PA) are the most prevalent fungal and bacterial pathogens isolated from the CF airway, respectively. Our aim was to determine the effect of different colonisation profiles of AF and PA on the clinical status of patients with CF. METHODS: A retrospective analysis of data from the Cystic Fibrosis Registry of Ireland from 2013 was performed to determine the effect of intermittent and persistent colonisation with AF or PA or co-colonisation with both microorganisms on clinical outcome measures in patients with CF...
April 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28423094/complications-of-chronic-necrotizing-pulmonary-aspergillosis-review-of-published-case-reports
#3
Aleksandra Barac, Tatjana Adzic Vukicevic, Aleksandra Dudvarski Ilic, Salvatore Rubino, Vladimir Zugic, Goran Stevanovic
Chronic necrotizing pulmonary aspergillosis (CNPA), a form of chronic pulmonary aspergillosis (CPA), affects immunocompetent or mildly immunocompromised persons with underlying pulmonary disease. These conditions are associated with high morbidity and mortality and often require long-term antifungal treatment. The long-term prognosis for patients with CNPA and the potential complications of CNPA have not been well documented. The aim of this study was to review published papers that report cases of CNPA complications and to highlight risk factors for development of CNPA...
April 13, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28422065/detection-of-1-3-%C3%AE-d-glucan-for-the-diagnosis-of-invasive-fungal-infection-in-liver-transplant-recipients
#4
Eric Levesque, Fadi Rizk, Zaid Noorah, Nawel Aït-Ammar, Catherine Cordonnier-Jourdin, Sarra El Anbassi, Christine Bonnal, Daniel Azoulay, Jean-Claude Merle, Françoise Botterel
Invasive fungal infections (IFI) are complications after liver transplantation involving high morbidity and mortality. (1,3)-β-d-glucan (BG) is a biomarker for IFI, but its utility remains uncertain. This study was designed to evaluate the impact of BG following their diagnosis. Between January 2013 and May 2016, 271 liver transplants were performed in our institution. Serum samples were tested for BG (Fungitell(®), Associates Cape Code Inc., Falmouth, MA, USA) at least weekly between liver transplantation and the discharge of patients...
April 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28395406/-expression-and-differential-diagnostic-value-of-serum-microrna-for-invasive-pulmonary-aspergillosis
#5
Z N Wen, Z G Ling, Y Huang, X Li
Objective: To explore the expression and the clinical diagnostic value of serum miR-21 for invasive pulmonary aspergillosis (IPA). Methods: Outpatients and inpatients from the Fourth Affiliated Hospital of Guangxi Medical University were included in the study during June 2014 to September 2015. The IPA group had 40 patients, male 22, female 18, aged 55-68 years (mean 60 ), while the control groups included 50 patients with pulmonary tuberculosis [male 23, female 27, aged 50-62 years (mean 55 )], 50 patients with lung cancer [male 30, female 20, aged 55-70 years (mean 62)], and 50 healthy controls [male 25, female 25, aged 50-67 years (mean 60) ]...
April 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28384860/fungal-opportunistic-pneumonias-in-hiv-aids-patients-an-indian-tertiary-care-experience
#6
Ravinder Kaur, Bhanu Mehra, Megh Singh Dhakad, Ritu Goyal, Preena Bhalla, Richa Dewan
INTRODUCTION: Opportunistic pneumonias are a major cause of mortality and morbidity in Human Immunodeficiency Virus (HIV) reactive patients. Despite the significant role that fungi play in causation of this opportunistic mycoses, very few Indian studies have attempted to investigate the burden and aetiological spectrum of HIV/AIDS-associated fungal pneumonias. AIM: To document the prevalence of fungal aetiology in HIV/AIDS-related opportunistic pneumonias in an Indian setting; and to elucidate the various fungal opportunists responsible for the same...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28384600/a-prospective-study-of-fungal-biomarkers-to-improve-management-of-invasive-fungal-diseases-in-a-mixed-specialty-critical-care-unit
#7
Alida Fe Talento, Katie Dunne, Eimear Ann Joyce, Michael Palmer, Elizabeth Johnson, P Lewis White, Jan Springer, Juergen Loeffler, Thomas Ryan, Daniel Collins, Thomas R Rogers
PURPOSE: The diagnosis of invasive fungal diseases (IFD) in critical care patients (CrCP) is difficult. The study investigated the performance of a set of biomarkers for diagnosis of IFD in a mixed specialty critical care unit (CrCU). METHODS: A prospective observational study in patients receiving critical care for ≥7days was performed. Serum samples were tested for the presence of: (1-3) - β-d-glucan (BDG), galactomannan (GM), and Aspergillus fumigatus DNA...
March 30, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28379569/one-health-pathogens-in-the-aspergillus-viridinutans-complex
#8
Jessica J Talbot, Vanessa R Barrs
Cryptic species in Aspergillus section Fumigati are increasingly recognised as pathogens in humans and animals. The A. viridinutans complex (AVC) has recently expanded to comprise 10 species, of which six are known to be pathogenic, including A. udagawae, A. felis, A. pseudofelis, A. parafelis, A. pseudoviridinutans, and A. wyomingensis. They cause locally invasive and disseminated invasive disease syndromes, including chronic pulmonary aspergillosis and invasive aspergillosis in humans, invasive fungal rhinosinusitis in cats, and disseminated invasive aspergillosis in dogs...
March 31, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28379304/changes-in-in-vitro-susceptibility-patterns-of-aspergillus-to-triazoles-and-correlation-with-aspergillosis-outcome-in-a-tertiary-care-cancer-center-1999-2015
#9
Sang Taek Heo, Alexander M Tatara, Cristina Jiménez-Ortigosa, Ying Jiang, Russell E Lewis, Jeffrey Tarrand, Frank Tverdek, Nathaniel D Albert, Paul E Verweij, Jacques F Meis, Antonios G Mikos, David S Perlin, Dimitrios P Kontoyiannis
Background.: Azole-resistant aspergillosis in high risk patients with hematological malignancy or hematopoietic stem cell transplantation (HSCT) is a cause of concern. Methods.: We examined changes over time in triazole MICs (CLSI method) of 290 sequential Aspergillus isolates recovered from respiratory sources from 1999-2002 (before introduction of the Aspergillus-potent triazoles voriconazole and posaconazole) and 2003-2015 at MD Anderson Cancer Center. We also tested for polymorphisms in ergosterol biosynthetic genes (cyp51A, erg3C, erg1) in the 37 A...
March 31, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28377877/invasive-aspergillosis-related-to-ibrutinib-therapy-for-chronic-lymphocytic-leukemia
#10
Benjamin Arthurs, Kathy Wunderle, Maylee Hsu, Suil Kim
We report a case of invasive pulmonary aspergillosis in a patient taking ibrutinib, a Bruton's tyrosine kinase inhibitor used to treat refractory chronic lymphocytic leukemia. We hypothesize that ibrutinib promoted this infection by suppressing innate immune responses against Aspergillus. Clinicians should be aware of potential Aspergillus infections in patients treated with this drug.
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28360463/prevalence-of-aspergillus-hypersensitivity-and-allergic-bronchopulmonary-aspergillosis-in-patients-with-bronchial-asthma-at-a-tertiary-care-center-in-north-india
#11
Alok Nath, Ajmal Khan, Zia Hashim, Jeetendra Kumar Patra
BACKGROUND: The prevalence of Aspergillus hypersensitivity (AH) and allergic bronchopulmonary aspergillosis (ABPA) has been variably reported. Systematic data regarding Aspergillus sensitization and ABPA are lacking from this part of the country. OBJECTIVES: The aim of this study was to evaluate the prevalence of AH and ABPA in Uttar Pradesh. SETTING AND DESIGN: This was prospective observational study. All patients attending outpatient Department of Pulmonary Medicine of our institute were included in the study...
March 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28355466/invasive-mould-infections-in-the-icu-setting-complexities-and-solutions
#12
Matteo Bassetti, Emilio Bouza
Infections caused by filamentous fungi represent a major burden in the ICU. Invasive aspergillosis is emerging in non-neutropenic individuals with predisposing conditions, e.g. corticosteroid treatment, chronic obstructive pulmonary disease, liver cirrhosis, solid organ cancer, HIV infection and transplantation. Diagnosis is challenging because the signs and symptoms are non-specific, and initiation of additional diagnostic examinations is often delayed because clinical suspicion is low. Isolation of an Aspergillus species from the respiratory tract in critically ill patients, and tests such as serum galactomannan, bronchoalveolar lavage 1-3-β-d-glucan and specific PCR should be interpreted with caution...
March 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28330887/usefulness-of-two-aspergillus-pcr-assays-and-aspergillus-galactomannan-and-%C3%AE-d-glucan-testing-of-bronchoalveolar-lavage-fluid-for-diagnosis-of-chronic-pulmonary-aspergillosis
#13
Naohisa Urabe, Susumu Sakamoto, Go Sano, Junko Suzuki, Akira Hebisawa, Yasuhiko Nakamura, Kazuya Koyama, Yoshikazu Ishii, Kazuhiro Tateda, Sakae Homma
We evaluated the usefulness of an Aspergillus galactomannan (GM) test, a β-D-glucan (βDG) test, and two different Aspergillus polymerase chain reaction (PCR) assays of bronchoalveolar lavage fluid (BALF) samples for diagnosis of chronic pulmonary aspergillosis (CPA). BALF samples from 28 patients with and 120 patients without CPA were collected. We calculated the sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio for each test individually and in combination with other tests...
March 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28317305/invasive-pulmonary-aspergillosis-due-to-azole-resistant-aspergillus-lentulus
#14
Nobuyuki Tetsuka, Takashi Yaguchi, Hiroyuki Machida, Shuichi Ito, Isao Miyairi
No abstract text is available yet for this article.
March 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28299723/mold-and-human-health-a-reality-check
#15
REVIEW
Andrea T Borchers, Christopher Chang, M Eric Gershwin
There are possibly millions of mold species on earth. The vast majority of these mold spores live in harmony with humans, rarely causing disease. The rare species that does cause disease does so by triggering allergies or asthma, or may be involved in hypersensitivity diseases such as allergic bronchopulmonary aspergillosis or allergic fungal sinusitis. Other hypersensitivity diseases include those related to occupational or domiciliary exposures to certain mold species, as in the case of Pigeon Breeder's disease, Farmer's lung, or humidifier fever...
March 16, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28293759/serious-fungal-diseases-in-the-republic-of-uzbekistan
#16
S A Tilavberdiev, D W Denning, N N Klimko
We have undertaken the first and preliminary estimation of severe and chronic mycotic diseases in the Republic of Uzbekistan, using a model proposed by LIFE (Leading International Fungal Education). Calculation was carried out based on data from 2014. Published results describing mycoses in Uzbekistan were identified. In the absence of published or official data, information about the frequency of mycoses from scientific literature elsewhere in groups at risk of development of fungal infections were taken into account...
March 14, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28292284/is-bulpa-criteria-suitable-for-the-diagnosis-of-probable-invasive-pulmonary-aspergillosis-in-critically-ill-patients-with-chronic-obstructive-pulmonary-disease-a-comparative-study-with-eortc-msg-and-icu-criteria
#17
Linna Huang, Hangyong He, Jingjing Jin, Qingyuan Zhan
BACKGROUND: Three diagnostic criteria have been proposed used for invasive pulmonary aspergillosis (IPA) diagnosis, namely EORTC/ MSG criteria, Bulpa criteria and intensive care unit (ICU) criteria. The Bulpa criteria were proposed to diagnose IPA in chronic obstructive pulmonary disease (COPD) patients specially. Our aim is to verify that whether the Bulpa criteria are the most suitable for diagnosing probable IPA in critically ill COPD patients compared with the other two criteria. METHODS: We included critically ill COPD patients admitted to the ICU from April 2006 to August 2013...
March 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28284662/effect-of-a-150%C3%A2-mg-dose-of-rifabutin-on-serum-itraconazole-levels-in-patients-with-coexisting-chronic-pulmonary-aspergillosis-and-mycobacterium-avium-complex-lung-disease
#18
Seong Mi Moon, Byung Woo Jhun, Hyun Lee, Hye Yun Park, Kyeongman Jeon, Soo-Youn Lee, Won-Jung Koh
Patients with coexisting chronic pulmonary aspergillosis and nontuberculous mycobacterial lung disease may undergo treatment with both the antifungal itraconazole and the antimycobacterial rifamycin. However, rifamycins interact with itraconazole. We examined the effects of a 150 mg dose of rifabutin on serum itraconazole levels and found significantly lower levels in 28 patients receiving itraconazole with rifabutin (median, 0.65 μg/ml) compared with 65 patients receiving itraconazole alone (median 3.45 μg/ml, P < 0...
March 8, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28275535/invasive-pulmonary-aspergillosis-in-a-steroid-dependent-asthmatic
#19
Bibi Aneesah Jaumally, Ahmed M Salem, Ala Eddin Sagar, George Pyrgos
No abstract text is available yet for this article.
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28275471/immunity-status-of-invasive-pulmonary-aspergillosis-patients-with-structural-lung-diseases-in-chinese-adults
#20
Shuo Liang, Rong Jiang, Hai-Wen Lu, Bei Mao, Man-Hui Li, Cheng-Wei Li, Shu-Yi Gu, Jiu-Wu Bai, Jin-Fu Xu
BACKGROUND: Invasive pulmonary aspergillosis (IPA) is a fungal infection frequently observed in patients with immune dysfunction, such as those suffering from structural lung diseases. Nevertheless, studies assessing IPA combined with other common respiratory diseases remain scarce, particularly those regarding the immune status of its patients. Different structural lung diseases are known to differently affect patient immune status; however, the mechanisms by which this is conferred have yet to be determined...
February 2017: Journal of Thoracic Disease
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