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Pulmonary aspergillosis

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https://www.readbyqxmd.com/read/29128933/proven-invasive-pulmonary-aspergillosis-in-stem-cell-transplant-recipient-due-to-aspergillus-sublatus-a-cryptic-species-of-a-nidulans
#1
Vanda Chrenkova, Vit Hubka, Petr Cetkovsky, Michal Kouba, Barbora Weinbergerova, Pavlina Lyskova, Ludmila Hornofova, Petr Hubacek
Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Autopsy samples revealed histopathological evidence of fungal hyphae and an unusual Aspergillus nidulans-like species was isolated in pure culture...
November 11, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29126660/evaluation-of-the-efficacy-of-a-posaconazole-and-anidulafungin-combination-in-a-murine-model-of-pulmonary-aspergillosis-due-to-infection-with-aspergillus-fumigatus
#2
Laura Bedin Denardi, Francielli Pantella Kunz de Jesus, Jéssica Tairine Keller, Carla Weiblen, Maria Isabel de Azevedo, Vanessa Oliveira, Janio Morais Santurio, Sydney Hartz Alves
Posaconazole (PSC) in combination with anidulafungin (AFG) was evaluated in a murine model of pulmonary aspergillosis. Immunosuppressed animals were infected via the nasal cavity with 2 different A. fumigatus strains. The animals received PSC (oral, 20mg/kg per day) and/or AFG (i.p., 10mg/kg per day) for 7days. On Day 8, the mice were euthanized and fungal burdens were determined from the lungs. Survival curves were constructed for mortality analysis. Compared to untreated groups, groups singly treated with PSC or AFG showed a reduced fungal burden in the lungs (P=0...
October 12, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29126309/a-cpanet-consensus-statement-on-research-priorities-for-chronic-pulmonary-aspergillosis-a-neglected-fungal-infection-that-requires-attention
#3
Cendrine Godet, Ana Alastruey-Izquierdo, Holger Flick, Christophe Hennequin, Rihards Mikilps-Mikgelbs, Oxana Munteanu, Iain Page, Danila Seidel, Helmut J F Salzer
Chronic pulmonary aspergillosis (CPA) is a severe fungal infection with a high morbidity and mortality, and is usually seen in immunocompetent patients with respiratory disorders. Clinical presentation is nonspecific and often overlaps with the symptoms and the radiological pattern caused by the underlying disease. Clinical management of CPA is further hampered by limited information about the epidemiology, disease dynamics, sensitivity and specificity of different mycological tests, mechanisms of antifungal resistance, efficient treatment and management strategies...
November 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29125713/outbreak-of-invasive-aspergillosis-in-heart-transplant-recipients-the-role-of-screening-computed-tomography-scans-in-asymptomatic-patients-and-universal-antifungal-prophylaxis
#4
Dima Kabbani, Livia Goldraich, Heather Ross, Coleman Rotstein, Shahid Husain
BACKGROUND: Delays in diagnosing invasive pulmonary aspergillosis (IA), a significant cause of morbidity and mortality among heart transplant recipients (HTRs), may impact on successful treatment. The appropriate screening strategy for IA in these patients remains undefined, particularly in the setting of nosocomial outbreaks. We describe our experience employing chest computed tomography (CT) scans as a screening method for IA. In addition, we comment on antimicrobial prophylaxis in HTRs in the setting of an outbreak...
November 10, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29125660/primary-prophylaxis-of-invasive-fungal-infections-with-posaconazole-or-itraconazole-in-patients-with-acute-myeloid-leukemia-or-high-risk-myelodysplastic-syndromes-undergoing-intensive-cytotoxic-chemotherapy-a-real-world-comparison
#5
Mar Tormo, Ariadna Pérez-Martínez, Marisa Calabuig, Juan Carlos Hernández-Boluda, Paula Amat, David Navarro, Carlos Solano
This is an observational-retrospective study comparing the real-world outcomes associated with posaconazole vs. itraconazole as prophylaxis treatments. Two hundred and ninety-three patient admissions attributable to 174 patients were included in the study. Patients were treated with itraconazole (n = 114 admissions; 39%) or posaconazole (n = 179; 61%). Antifungal prophylaxis failure (APF) due to treatment-related adverse events (in 34 out of 293 patient admissions; 11.6%) was more frequent in the posaconazole group (6...
November 10, 2017: Mycoses
https://www.readbyqxmd.com/read/29112326/real-world-challenges-and-unmet-needs-in-the-diagnosis-and-treatment-of-suspected-invasive-pulmonary-aspergillosis-in-patients-with-hematological-diseases-an-illustrative-case-study
#6
Martin Hoenigl, Juergen Prattes, Peter Neumeister, Albert Wölfler, Robert Krause
Recent years have seen important advances in the diagnosis of invasive pulmonary aspergillosis (IPA), complemented by the introduction of new therapies. Despite this, IPA remains a major cause of infection-related mortality in patients with hematological diseases. There are two main reasons for this. First, diagnosis of IPA remains a challenge, since risk factors and the clinical, radiological and mycological presentations vary not only by fungal disease stage, but also by patient group (e.g. neutropenic versus non-neutropenic patients)...
November 7, 2017: Mycoses
https://www.readbyqxmd.com/read/29102972/urinary-tract-aspergillosis-in-a-patient-with-chronic-kidney-disease
#7
Linghong Zhou, Huazhen Zhao, Zhongqing Chen, Liping Zhu
Invasive aspergillosis is a life-threatening fungal infection, especially in immunocompromised patients. Pulmonary aspergillosis is the most common type of the infection, while urinary tract infection is relatively rare. Here, we describe a case of a 46-year-old man with chronic renal disease presenting with intermittent abdominal pain. The diagnosis of aspergillosis was established by pathological findings of the fungal ball in the bladder. The patient underwent multiple antimicrobial treatments and surgical interventions and was finally cured by posaconazole...
November 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29099912/toward-the-identification-of-a-genetic-risk-signature-for-pulmonary-aspergillosis-in-copd
#8
Cristina Cunha, Agostinho Carvalho
No abstract text is available yet for this article.
November 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29081110/-coal-workers-s-pneumoconiosis-combined-with-invasive-pulmonary-aspergillosis-a-case-report
#9
Y R Wang, Q Ye
No abstract text is available yet for this article.
July 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29075583/invasive-aspergillosis-involving-the-mediastinum-in-an-immunocompetent-patient-a-case-report
#10
Manesh Kumar Gangwani, Muhammad Aziz, Siraj Munir, Syed Ahsan Ali
We report a rare case of invasive pulmonary aspergillosis invading the mediastinum and the left atrium. A 38-year-old female was hospitalized for cough, shortness of breath and fever. She had a past medical history of tuberculosis. Computed tomography (CT) scans identified an ill-defined enhancing mediastinal soft tissue density mass encasing the heart and major vessels. The cardiac echocardiography showed global hypokinesia, low ejection fraction and a large echogenic density in the left atrium. The pathology from the bronchoscopic biopsy observed abundant fungal hyphae which were stained with periodic Acid-Schiff and Gomori's methenamine silver...
August 24, 2017: Curēus
https://www.readbyqxmd.com/read/29067630/pulmonary-aspergillus-overlap-syndromes
#11
Liyang Li, Zhilong Jiang, Changzhou Shao
BACKGROUND: Broadly, there are three main categories in pulmonary aspergillosis: chronic forms of aspergillosis; allergic bronchopulmonary aspergillosis; and invasive aspergillosis (IPA). IPA has been further subdivided into angioinvasive and airway-invasive aspergillosis. Aspergillus overlap syndromes is defined as the occurrence of more than one form aspergillus disease in a single individual. OBJECTIVES: To help clinicians correctly deal with AOS. METHODS: Retrospectively study the clinical findings of nine patients presenting with AOS...
October 24, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29052351/analysis-of-the-clinical-features-of-invasive-bronchopulmonary-aspergillosis
#12
Yueqin Cao, Changzhou Shao, Yuanlin Song
INTRODUCTION: Early diagnosis of invasive bronchopulmonary aspergillosis (IBPA) is difficult, so the mortality rate is high. OBJECTIVE: To discuss the clinical features of IBPA. METHODS: We retrospectively analyzed the clinical features, imaging findings, laboratory test, diagnosis, and treatment of 115 patients with IBPA diagnosed from October 2004 to June 2013 in Zhongshan Hospital, Fudan University. RESULTS: The main clinical manifestations were cough in 58 patients (50...
October 20, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29050136/-classification-and-surgery-of-chronic-pulmonary-aspergillosis
#13
C H Yun, W Zhou, Y W Rui
No abstract text is available yet for this article.
October 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29049319/clinical-outcome-and-prognostic-factors-associated-with-invasive-pulmonary-aspergillosis-an-11-year-follow-up-report-from-taiwan
#14
Kuo-Shao Sun, Ching-Fang Tsai, Solomon Chih-Cheng Chen, Wan-Chun Huang
BACKGROUND: Invasive pulmonary aspergillosis (IPA) has high mortality rate but prognostic factors are not well established. The aim of our study was to evaluate the trend in in-hospital mortality over a period of 11 years and identify factors affecting the clinical outcomes of patients with IPA. METHOD: We conducted a nationwide inpatient population study using data from the Taiwan National Health Insurance Research Database. A total of 407 IPA patients from 2002 to 2012 were included in the study...
2017: PloS One
https://www.readbyqxmd.com/read/29049239/clinical-features-and-diagnosis-of-chronic-pulmonary-aspergillosis-in-chinese-patients
#15
Xiaomeng Hou, Hong Zhang, Lei Kou, Wei Lv, Jingjing Lu, Ji Li
Chronic pulmonary aspergillosis (CPA) has recently been recognized as a significant global health burden. In China, the diagnosis of CPA is still unfamiliar to most doctors. The aim of this study was to demonstrate the clinical manifestations and diagnoses of CPA in China.A multidisciplinary team of doctors retrospectively screened 690 records of patients diagnosed with pulmonary aspergillosis from January 2000 to December 2016 at Peking Union Medical College Hospital, Beijing, China. Of these, 69 patients were diagnosed with CPA...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049191/significance-of-monitoring-plasma-concentration-of-voriconazole-in-a-patient-with-liver-failure-a-case-report
#16
Xiaoyan Liu, Haibin Su, Jingjing Tong, Jing Chen, Haozhen Yang, Long Xiao, Jinhua Hu, Lina Zhang
RATIONALE: Invasive pulmonary aspergillosis is associated with significant morbidity and mortality in patients with liver failure. Voriconazole (VRCZ) is recommended as a primary therapeutic agent for the treatment of invasive aspergillosis and metabolized in the liver. Now, data are still lacking on the safety and appropriate dosage of VRCZ in patients with liver failure. Here, we report a representative case of invasive pulmonary fungal infection in a patient with liver failure who was treated with low-dose VRCZ...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29035608/f508del-cftr-gene-mutation-in-patients-with-allergic-bronchopulmonary-aspergillosis
#17
Maria N Gamaletsou, Gemma Hayes, Chris Harris, Joanna Brock, Eavan G Muldoon, David W Denning
OBJECTIVE: The F508del mutation occurs in approximately 3.5% of Caucasian population of Northern Europe. Heterozygotes have increased risk for asthma and reduced pulmonary function. Allergic bronchopulmonary aspergillosis (ABPA) is more common in patients with cystic fibrosis (CF). We aimed to establish the frequency of F508del mutation in adult patients with ABPA. METHODS: A retrospective matched case-control study of CF genotyped patients with ABPA seen at the National Aspergillosis Centre was undertaken...
October 16, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29020397/pentraxin-3-gene-polymorphisms-and-pulmonary-aspergillosis-in-copd-patients
#18
Qian He, Hongxing Li, Yuwen Rui, Lulu Liu, Binchan He, Yi Shi, Xin Su
Background: Pentraxin 3 (PTX3) plays an important role in resistance to Aspergillus infections. Previous studies have suggested that PTX3 polymorphisms influence the risk of invasive aspergillosis among transplantation recipients. This study was to investigate the association between PTX3 gene polymorphisms and pulmonary aspergillosis in chronic obstructive pulmonary disease (COPD) population. Methods: We included 173 consecutive inpatients with COPD. 36 cases were finally diagnosed with pulmonary aspergillosis...
August 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28992055/amphotericin-b-concentrations-in-healthy-mallard-ducks-anas-platyrhynchos-following-a-single-intratracheal-dose-of-liposomal-amphotericin-b-using-an-atomizer
#19
Ashley Phillips, Christine V Fiorello, Rachel M Baden, Jack H Liu, Nathaniel C Burmas, Carlos A Ruvalcaba, Roger Monroy, F Charles Mohr, Ronette Gehring, Jean-Pierre Delplanque, Karl V Clemons, David A Stevens, Lisa A Tell
Aspergillosis is a fungal infection that primarily affects the respiratory tract. Amphotericin B has broad antifungal activity and is commonly used to treat aspergillosis, a fungal pneumonia that is a common sequela in oiled waterfowl as well as other birds in wildlife rehabilitation. Pharmacokinetic parameters of nebulized amphotericin B in an avian model have been reported, but those of direct intratracheal delivery have yet to be established. The objective of this study was to evaluate if a single 3 mg/kg dose of liposomal amphotericin B delivered intratracheally using a commercial atomizer would achieve plasma and lung tissue concentrations exceeding targeted minimum inhibitory concentrations (MIC) for Aspergillus species in adult mallard ducks (Anas platyrhynchos)...
August 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28990897/chronic-necrotizing-pulmonary-aspergillosis-in-an-immunocompetent-patient-after-the-surgery-of-hydatid-cyst
#20
Nagehan Emiralioğlu, Hatice Nursun Özcan, Diclehan Orhan, Mithat Haliloğlu, Ali Bülent Cengiz, Elmas Ebru Yalçın, Deniz Doğru Ersöz, Nural Kiper, Hayriye Uğur Özçelik
Chronic necrotizing pulmonary aspergillosis (CNPA) is a condition caused by the ubiquitous fungus Aspergillus fumigatus in non-immunocompromised individuals. Numerous underlying conditions have been associated with CNPA. Tuberculosis, non-tuberculous mycobacterial infection and allergic bronchopulmonary aspergillosis (ABPA) remain the predominant risk factors for development of CNPA. Development of CNPA in echinococcal cyst cavities is very rare and the optimal therapeutic regimen and treatment duration have not been established...
June 2017: Tüberküloz Ve Toraks
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