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Simultaneous integrated boost

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https://www.readbyqxmd.com/read/29116237/advantages-of-a-technique-using-two-50-degree-arcs-in-simultaneous-integrated-boost-radiotherapy-for-left-sidebreast-cancer
#1
Dan Xi, Yun Ding, Rui Hu, Wendong Gu, Jinming Mu, Qilin Li
This study evaluated radiotherapy techniques with 15 cases for simultaneous integrated boost to treat whole left breast and tumor bed following breast conserving surgery. Treatment plans were generated using three techniques: volumetric modulated arc therapy (VMAT) with a partial arc of 190° (1ARC), VMAT with two tangential mini-arcs of 50° each (2TARC) and intensity modulated radiation therapy with four fixed angle fields (4IMRT). Dosimetric parameters for the whole breast (Target), the boost tumor bed (Boost), and surrounding normal organs were compared...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29110926/study-for-reducing-lung-dose-of-upper-thoracic-esophageal-cancer-radiotherapy-by-auto-planning-volumetric-modulated-arc-therapy-vs-intensity-modulated-radiation-therapy
#2
Hua Chen, Hao Wang, Hengle Gu, Yan Shao, Xuwei Cai, Xiaolong Fu, Zhiyong Xu
This study aimed to investigate the dosimetric differences and lung sparing between volumetric-modulated arc therapy (VMAT) and intensity-modulated radiation therapy (IMRT) in the treatment of upper thoracic esophageal cancer with T3N0M0 for preoperative radiotherapy by auto-planning (AP). Sixteen patient cases diagnosed with upper thoracic esophageal cancer T3N0M0 for preoperative radiotherapy were retrospectively studied, and 3 plans were generated for each patient: full arc VMAT AP plan with double arcs, partial arc VMAT AP plan with 6 partial arcs, and conventional IMRT AP plan...
October 27, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29094268/comparison-of-intensity-modulated-radiotherapy-with-simultaneous-integrated-boost-imrt-sib-and-a-3-dimensional-conformal-parotid-gland-sparing-radiotherapy-conpas-3d-crt-in-treatment-of-nasopharyngeal-carcinoma-a-mono-institutional-experience
#3
Vesna Bišof, Zoran Rakušić, Juraj Bibić, Timor Grego, Majana Soče
AIM: To compare intensity modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) and a 3-dimensional conformal parotid gland-sparing radiotherapy (ConPas 3D-CRT) in treatment of nasopharyngeal carcinoma with regard to outcomes and dose distribution to the planning target volumes (PTVs) and to the organs at risk (OARs). METHODS: The treatment records of 24 patients with histologically proven carcinoma of the nasopharynx treated with ConPas 3D-CRT or IMRT-SIB technique between May 2009 and December 2016 were assessed...
November 1, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/29074078/the-impact-of-treatment-accuracy-on-proton-therapy-patient-selection-for-oropharyngeal-cancer-patients
#4
Tine Arts, Sebastiaan Breedveld, Martin A de Jong, Eleftheria Astreinidou, Lisa Tans, Fatma Keskin-Cambay, Augustinus D G Krol, Steven van de Water, Rik G Bijman, Mischa S Hoogeman
BACKGROUND AND PURPOSE: The impact of treatment accuracy on NTCP-based patient selection for proton therapy is currently unknown. This study investigates this impact for oropharyngeal cancer patients. MATERIALS AND METHODS: Data of 78 patients was used to automatically generate treatment plans for a simultaneously integrated boost prescribing 70 GyRBE/54.25 GyRBE in 35 fractions. IMRT treatment plans were generated with three different margins; intensity modulated proton therapy (IMPT) plans for five different setup and range robustness settings...
October 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29066917/clinical-outcome-and-toxicity-evaluation-of-simultaneous-integrated-boost-pelvic-imrt-vmat-at-different-dose-levels-combined-with-androgen-deprivation-therapy-in-prostate-cancer-patients
#5
Mohamed A Daoud, Engy M Aboelnaga, Mohamed S Alashry, Salwa Fathy, Mostafa A Aletreby
BACKGROUND: The role of dose escalation in patients receiving long-term androgen deprivation therapy (ADT) is still a controversial issue. The aim of the current study was to evaluate whether dose escalation for ≥76-80 Gy had any advantage in terms of biochemical disease-free survival (BDFS), distant metastasis-free survival (DMFS), or overall survival outcomes over the dose levels from 70 to <76 Gy. PATIENTS AND METHODS: The study included a cohort of 24 patients classified with high- and intermediate-risk localized prostate cancer...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29054379/treatment-log-files-as-a-tool-to-identify-treatment-plan-sensitivity-to-inaccuracies-in-scanned-proton-beam-delivery
#6
Maria Francesca Belosi, Robert van der Meer, Paz Garcia de Acilu Laa, Alessandra Bolsi, Damien C Weber, Antony J Lomax
Dose distributions delivered at Gantry 2 at the Paul Scherrer Institut (PSI) can be reconstructed on the patient anatomy based on machine log files. With the present work, the dependency of the log file calculation on the planning optimization technique and on other planning parameters, such as field direction and tumour size, has been investigated. Interestingly, and despite the typically higher modulation of Intensity Modulated Proton Therapy (IMPT) plans, the results for both Single Field Uniform Distribution and IMPT approaches have been found to be similar...
October 17, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29037023/simultaneous-integrated-boost-intensity-modulated-radiotherapy-versus-3-dimensional-conformal-radiotherapy-in-preoperative-concurrent-chemoradiotherapy-for-locally-advanced-rectal-cancer
#7
Bong Kyung Bae, Min Kyu Kang, Jae-Chul Kim, Mi Young Kim, Gyu-Seog Choi, Jong Gwang Kim, Byung Woog Kang, Hye Jin Kim, Soo Yeun Park
PURPOSE: To evaluate the feasibility of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) for preoperative concurrent chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC), by comparing with 3-dimensional conformal radiotherapy (3D-CRT). MATERIALS AND METHODS: Patients who were treated with PCRT for LARC from 2015 January to 2016 December were retrospectively enrolled. Total doses of 45 Gy to 50.4 Gy with 3D-CRT or SIB-IMRT were administered concomitantly with 5-fluorouracil plus leucovorin or capecitabine...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29023527/dose-escalated-radiotherapy-for-unresectable-or-locally-recurrent-pancreatic-cancer-dose-volume-analysis-toxicity-and-outcome-of-28-consecutive-patients
#8
Sebastian Zschaeck, Bibiana Blümke, Peter Wust, David Kaul, Marcus Bahra, Hanno Riess, Fritz Klein, Marianne Sinn, Uwe Pelzer, Volker Budach, Pirus Ghadjar
PURPOSE: The role of radiotherapy for unresectable pancreatic cancer is controversial. A benefit of additional radiotherapy is supported by some observations. A dose-effect relationship was recently found by dose escalation employing image guided and intensity modulated radiotherapy. METHODS: We retrospectively evaluated 28 consecutive patients, all with history of extensive prior therapies for unresectable locally advanced/ recurrent pancreatic cancer (LAPC/LRPC)...
2017: PloS One
https://www.readbyqxmd.com/read/28984752/intensity-modulated-radiation-therapy-for-patients-with-1-to-3-brain-metastases-in-recursive-partitioning-analysis-class-3
#9
Jia Yang, Wenming Zhan, Haibo Zhang, Tao Song, Yongshi Jia, Hongen Xu, Baihua Lin, Shiliang Lv, Xiaodong Liang
The prognosis is extremely poor for patients with brain metastases in recursive partitioning analysis (RPA) class 3. It is not clear whether dose elevation for brain lesions in addition to whole-brain radiotherapy could improve survival for those patients. This study aimed to assess the efficacy and safety of dose elevation with intensity-modulated radiation therapy (IMRT) for patients with 1 to 3 brain metastases in RPA class 3.From January 2013 to December 2015, 24 patients with 1 to 3 brain metastases in RPA class 3 were included in this study...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28982907/hypofractionated-postoperative-imrt-in-prostate-carcinoma-a-phase-i-ii-study
#10
Gabriella Macchia, Giambattista Siepe, Ilaria Capocaccia, Nam P Nguyen, Riccardo Schiavina, Silvia Cammelli, Sara Guerri, Alessandra Arcelli, Milly Buwenge, Maria Ntreta, Savino Cilla, Vincenzo Valentini, Francesco Deodato, Alessio G Morganti
AIM: To report the outcome of hypofractionated radiotherapy after radical prostatectomy (RP) for prostate cancer (PCa) using simultaneous integrated boost-intensity modulated radiation therapy (SIB-IMRT). PATIENTS AND METHODS: A total of 124 patients with PCa at high risk of relapse after RP or diagnosis of biochemical relapse were included. Patients received 62.5 Gy to the prostate bed and 45 Gy to pelvic nodes in 25 fractions. Androgen-suppressive therapy was prescribed based on National Comprehensive Cancer Network risk categories...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28963789/-18-f-fluoromisonidazole-positron-emission-tomography-ct-guided-volumetric-modulated-arc-therapy-based-dose-escalation-for-hypoxic-subvolume-in-nasopharyngeal-carcinomas-a-feasibility-study
#11
Jianjian Qiu, Bo Lv, Meina Fu, Xianglian Wang, Xiangpeng Zheng, Weihai Zhuo
BACKGROUND: The purpose of this study is to investigate the feasibility of a simultaneously integrated boost to the hypoxic subvolume of nasopharyngeal carcinomas (NCPs) under the guidance of (18) F-fluoromisonidazole (FMISO) positron emission tomography (PET)/CT using volumetric-modulated arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) techniques. METHODS: Eight patients with NPC were treated with simultaneous integrated boost-IMRT (treatment plan named IMRT70) with dose prescriptions of 70 Gy, 66 Gy, 60 Gy, and 54 Gy to the gross tumor volume (GTV), positive neck nodes, the planning target volume (PTV), and the clinically negative neck, respectively...
September 30, 2017: Head & Neck
https://www.readbyqxmd.com/read/28939083/incidence-and-dosimetric-parameters-for-brainstem-necrosis-following-intensity-modulated-radiation-therapy-in-nasopharyngeal-carcinoma
#12
Yang-Chan Li, Fo-Ping Chen, Guan-Qun Zhou, Jin-Han Zhu, Jiang Hu, De-Hua Kang, Chen-Fei Wu, Li Lin, Xiao-Ju Wang, Jun Ma, Ying Sun
OBJECTIVES: To clarify the incidence of brainstem toxicity and perform a dose-volume analysis for the brainstem after long-term follow-up of a large cohort of nasopharyngeal carcinoma (NPC) patients who underwent intensity-modulated radiation therapy (IMRT). MATERIALS AND METHODS: All patients with NPC treated with IMRT at Sun Yat-sen University Cancer Center between April 2009 and March 2012 were retrospectively reviewed. A total of 1544 patients with follow-up >12months and detailed treatment plan data were included...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28934968/comparison-of-volumetric-modulated-arc-therapy-using-simultaneous-integrated-boosts-sib-vmat-of-45%C3%A2-gy-55%C3%A2-gy-in-25-fractions-with-conventional-radiotherapy-in-preoperative-chemoradiation-for-rectal-cancers-a-propensity-score-case-matched-analysis
#13
Hideomi Yamashita, Soichiro Ishihara, Hiroaki Nozawa, Kazushige Kawai, Tomomichi Kiyomatsu, Kae Okuma, Osamu Abe, Toshiaki Watanabe, Keiichi Nakagawa
BACKGROUND AND PURPOSE: The aim of this retrospective study was to compare volumetric-modulated arc therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in 25 fractions with three-dimensional conformal radiotherapy (3D-CRT) in preoperative chemoradiation for rectal cancers. METHODS AND MATERIALS: In the propensity score-matching analysis of 1:2, we selected 60 patients from the SIB-VMAT group and 120patients from the 3D-CRT group matched pairings out of 145 patients between 2005 and 2015...
September 21, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28931343/impact-of-bowel-gas-and-body-outline-variations-on-total-accumulated-dose-with-intensity-modulated-proton-therapy-in-locally-advanced-cervical-cancer-patients
#14
Thomas Berger, Jørgen Breede Baltzer Petersen, Jacob Christian Lindegaard, Lars Ulrik Fokdal, Kari Tanderup
INTRODUCTION: Density changes occurring during fractionated radiotherapy in the pelvic region may degrade proton dose distributions. The aim of the study was to quantify the dosimetric impact of gas cavities and body outline variations. MATERIAL AND METHODS: Seven patients with locally advanced cervical cancer (LACC) were analyzed through a total of 175 daily cone beam computed tomography (CBCT) scans. Four-beams intensity-modulated proton therapy (IMPT) dose plans were generated targeting the internal target volume (ITV) composed of: primary tumor, elective and pathological nodes...
September 21, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28893059/dosimetric-advantages-and-clinical-outcomes-of-simultaneous-integrated-boost-intensity-modulated-radiotherapy-for-anal-squamous-cell-carcinoma
#15
Katsuyuki Sakanaka, Satoshi Itasaka, Yuichi Ishida, Kota Fujii, Takahiro Horimatsu, Takashi Mizowaki, Yoshiharu Sakai, Masahiro Hiraoka
Purpose: The purpose of this study was to explore the dosimetric difference between simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) and three-dimensional conformal radiotherapy (3DCRT), and the clinical outcomes of anal squamous cell carcinoma (ASCC) chemoradiotherapy featuring SIB-IMRT. Materials and Methods: This study included ten patients with ASCC who underwent chemoradiotherapy using SIB-IMRT with 5-fluorouracil and mitomycin C. SIB-IMRT delivered 54 Gy to each primary tumor plus metastatic lymph nodes and 45 Gy to regional lymph nodes, in 30 fractions...
September 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28879459/hypofractionated-radiotherapy-with-simultaneous-integrated-boost-sib-plus-temozolomide-in-good-prognosis-patients-with-glioblastoma-a-multicenter-phase-ii-study-by-the-brain-study-group-of-the-italian-association-of-radiation-oncology-airo
#16
Silvia Scoccianti, Marco Krengli, Livia Marrazzo, Stefano Maria Magrini, Beatrice Detti, Vincenzo Fusco, Luigi Pirtoli, Daniela Doino, Alba Fiorentino, Laura Masini, Daniela Greto, Michela Buglione, Giovanni Rubino, Federico Lonardi, Fernanda Migliaccio, Salvino Marzano, Riccardo Santoni, Umberto Ricardi, Lorenzo Livi
INTRODUCTION: A multicenter phase II study for assessing the efficacy and the toxicity of hypofractionated radiotherapy with SIB plus temozolomide in patients with glioblastoma was carried out by the Brain Study Group of the Italian Association of Radiation Oncology. METHODS: Twenty-four patients with newly diagnosed glioblastoma belonging to Recursive Partitioning Analysis classes III and IV were enrolled. The prescribed dose was 52.5 Gy in 15 fractions of 3.5 Gy and 67...
September 6, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28876533/multi-objective-optimization-of-benzamide-derivatives-as-rho-kinase-inhibitors
#17
Giovanna Cardoso Gajo, Daniela Rodrigues Silva, Stephen J Barigye, Elaine Fontes Ferreira da Cunha
Despite recent advances in Computer Aided Drug Discovery and High Throughput Screening, the attrition rates of drug candidates continue to be high, underscoring the inherent complexity of the drug discovery paradigm. Indeed, a compromise between several objectives is often required to obtain successful clinical drugs. The present manuscript details a multi-objective workflow that integrates the 4D-QSAR and molecular docking methods in the simultaneous modeling of the Rho Kinase inhibitory activity and acute toxicity of Benzamide derivatives...
September 6, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28856848/image-guided-imrt-with-simultaneous-integrated-boost-as-per-rtog-0529-for-the-treatment-of-anal-cancer
#18
Francesca Arcadipane, Pierfrancesco Franco, Manuela Ceccarelli, Gabriella Furfaro, Nadia Rondi, Elisabetta Trino, Stefania Martini, Giuseppe Carlo Iorio, Massimiliano Mistrangelo, Paola Cassoni, Patrizia Racca, Mario Morino, Umberto Ricardi
AIM: To report on clinical outcomes of simultaneous integrated boost intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy as per Radiation Therapy Oncology Group (RTOG) 0529 protocol in anal cancer patients. METHODS: Clinical stage T1-T4 N0-N3 anal cancer patients were submitted to concomitant chemoradiation. Patients with cT2N0 disease were prescribed 50.4 Gy/28 fractions to the gross tumor planning target volume (PTV) and 42 Gy/28 fractions to the elective nodal PTV...
August 30, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28832174/-intensity-modulated-hyperfractionated-accelerated-radiotherapy-to-treat-advanced-head-and-neck-cancer-predictive-factors-of-overall-survival
#19
J Cvek, L Knybel, J Stránský, P Matoušek, O Res, K Zeleník, B Otáhal, L Molenda, E Skácelíková, N Stieberová, Z Čermáková, D Feltl
AIM: The aim of this study was to evaluate overall survival (OS) and prognostic factors in patients ineligible for chemotherapy who were treated with a hyperfractionated accelerated schedule with simultaneous integrated boost. MATERIAL AND METHODS: From May, 2008, to April, 2013, 122 patients with locally advanced nonmetastatic squamous laryngeal (14%), hypopharyngeal (30%), oropharyngeal (30%), and oral cavity (27%) cancer were treated at our institution. The median age, Karnofsky Performance Status (KPS), and gross tumor volume (GTV) of the patients were 63 years (range, 46-87 years), 80% (range, 50-100%), and 46 ml (range, 5-250 ml), resp...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28830475/preoperative-intensity-modulated-radiotherapy-with-a-simultaneous-integrated-boost-combined-with-capecitabine-in-locally-advanced-rectal-cancer-short-term-results-of-a-multicentric-study
#20
Marco Lupattelli, Fabio Matrone, Maria Antonietta Gambacorta, Mattia Osti, Gabriella Macchia, Elisa Palazzari, Luca Nicosia, Federico Navarria, Giuditta Chiloiro, Vincenzo Valentini, Cynthia Aristei, Antonino De Paoli
BACKGROUND: Preoperative radiotherapy (RT) in combination with fluoropyrimidine-based chemotherapy (CT) is the standard of care in patients with locally advanced, T3-T4 N0-2, rectal cancer (LARC). Given the correlation between RT dose-tumor response and the prognostic role of the tumor regression grade (TRG), treatment intensification represents an area of active investigation. The aim of the study was to analyze the role of RT dose-intensification in the preoperative treatment of LARC in terms of feasibility, efficacy and toxicity...
August 22, 2017: Radiation Oncology
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