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Simultaneous integrated boost

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https://www.readbyqxmd.com/read/28224401/synchronous-bilateral-breast-cancer-irradiation-clinical-and-dosimetrical-issues-using-volumetric-modulated-arc-therapy-and-simultaneous-integrated-boost
#1
Alba Fiorentino, Rosario Mazzola, Stefania Naccarato, Niccolò Giaj-Levra, Sergio Fersino, Gianluisa Sicignano, Umberto Tebano, Francesco Ricchetti, Ruggero Ruggieri, Filippo Alongi
OBJECTIVES: The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). METHODS: From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified...
February 21, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28222995/acute-and-late-toxicity-in-high-risk-prostate-cancer-patients-treated-with-androgen-suppression-and-hypofractionated-pelvic-radiation-therapy
#2
Sergio Faria, Russel Ruo, Fabio Cury, Marie Duclos, Luis Souhami
PURPOSE: To report acute and late toxicity rates in patients with high-risk prostate cancer treated with androgen deprivation therapy (ADT) and moderate hypofractionated radiation therapy (HypoRT) to the prostate and nodal areas. METHODS AND MATERIALS: Patients with localized, high-risk prostate cancer were treated with a HypoRT regimen of 60 Gy in 20 fractions (4 weeks) to the prostate volume while the nodal areas received 44 Gy in the same 20 fractions delivered with intensity modulated RT with a simultaneous integrated boost technique...
January 20, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28217713/catching-the-voltage-gradient-asymmetric-boost-of-cortical-spread-generates-motion-signals-across-visual-cortex-a-brief-review-with-special-thanks-to-amiram-grinvald
#3
REVIEW
Dirk Jancke
Wide-field voltage imaging is unique in its capability to capture snapshots of activity-across the full gradient of average changes in membrane potentials from subthreshold to suprathreshold levels-of hundreds of thousands of superficial cortical neurons that are simultaneously active. Here, I highlight two examples where voltage-sensitive dye imaging (VSDI) was exploited to track gradual space-time changes of activity within milliseconds across several millimeters of cortex at submillimeter resolution: the line-motion condition, measured in Amiram Grinvald's Laboratory more than 10 years ago and-coming full circle running VSDI in my laboratory-another motion-inducing condition, in which two neighboring stimuli counterchange luminance simultaneously...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/28214447/influence-of-pressures-up-to-50bar-on-two-stage-anaerobic-digestion
#4
Wolfgang Merkle, Katharina Baer, Jonas Lindner, Simon Zielonka, Felix Ortloff, Frank Graf, Thomas Kolb, Thomas Jungbluth, Andreas Lemmer
The concept of pressurized two-stage anaerobic digestion integrates biogas production, purification and pressure boosting within one process. The produced methane-rich biogas can be fed into gas grids with considerably less purification effort. To investigate biogas production under high pressures up to 50bar, a lab scale two-stage anaerobic digestion system was constructed including one continuously operated pressurized methane reactor. This investigation examined the effects of different operating pressures in methane reactor (10, 25, 50bar) on biogas quantity and quality, pH value and process stability...
February 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28197653/does-selective-pleural-irradiation-of-malignant-pleural-mesothelioma-allow-radiation-dose-escalation-a-planning-study
#5
A Botticella, G Defraene, K Nackaerts, C Deroose, J Coolen, P Nafteux, B Vanstraelen, S Joosten, L A W Michiels, S Peeters, D De Ruysscher
BACKGROUND: After lung-sparing radiotherapy for malignant pleural mesothelioma (MPM), local failure at sites of previous gross disease represents the dominant form of failure. Our aim is to investigate if selective irradiation of the gross pleural disease only can allow dose escalation. MATERIALS AND METHODS: In all, 12 consecutive stage I-IV MPM patients (6 left-sided and 6 right-sided) were retrospectively identified and included. A magnetic resonance imaging-based pleural gross tumor volume (GTV) was contoured...
February 14, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28190601/clinical-implementation-of-coverage-probability-planning-for-nodal-boosting-in-locally-advanced-cervical-cancer
#6
Anne Ramlov, Marianne S Assenholt, Maria F Jensen, Caroline Grønborg, Remi Nout, Markus Alber, Lars Fokdal, Kari Tanderup, Jacob Chr Lindegaard
PURPOSE: To implement coverage probability (CovP) for dose planning of simultaneous integrated boost (SIB) of pathologic lymph nodes in locally advanced cervical cancer (LACC). MATERIAL AND METHODS: CovP constraints for SIB of the pathological nodal target (PTV-N) with a central dose peak and a relaxed coverage at the perimeter were generated for use with the treatment planning system Eclipse: PTV-N D98 >90%, CTV-N D98 >100% and CTV-N D50 >101.5% of prescribed dose...
February 9, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28186838/biological-dose-escalated-definitive-radiation-therapy-in-head-and-neck-cancer
#7
Brigida da Costa Ferreira, Pedro Sá-Couto, Leila Khouri, Maria do Carmo Lopes
OBJECTIVE: To compare treatment outcome of patients with head and neck (HN) tumours treated with definitive Radiation Therapy (RT) that, mainly due to differences in the fractionation scheme used with simultaneous integrated boost techniques, resulted in a different biological dose. METHODS: 181 HN cancer patients, prescribed to about 70.2 Gy in the primary tumour, were included in this study. Population cohort was divided into Group <70 and Group ≥70 when the mean dose converted to a 2 Gy fractionation in the primary tumour was less or higher than 70...
February 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28181819/dose-escalation-study-with-respiratory-gated-carbon-ion-scanning-radiotherapy-using-a-simultaneous-integrated-boost-for-pancreatic-cancer-simulation-with-four-dimensional-computed-tomography
#8
Shohei Kawashiro, Shinichiro Mori, Shigeru Yamada, Kentaro Miki, Kenji Nemoto, Hiroshi Tsuji, Tadashi Kamada
OBJECTIVES: Pancreatic cancer is a difficult-to-treat disease with a persistently high mortality rate. We evaluated dose distribution simulation with respiratory-gated carbon-ion pencil beam scanning (C-PBS) with a simultaneous integrated boost (SIB) to increase tumor dose, sparing organs at risk (OARs). METHODS: Using four-dimensional computed tomography (4DCT) data of 12 patients, we delineated gross tumor volume (GTV) and two clinical target volumes (CTVs). To consider beam range intrafractional uncertainty, we calculated field-specific target volumes (FTVs), from which two planning target volumes (PTVs) were generated...
February 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28159552/contribution-of-image-guided-adaptive-brachytherapy-to-pelvic-nodes-treatment-in-locally-advanced-cervical-cancer
#9
Warren Bacorro, Isabelle Dumas, Antonin Levy, Eleonor Rivin Del Campo, Charles-Henri Canova, Tony Felefly, Andres Huertas, Fanny Marsolat, Christine Haie-Meder, Cyrus Chargari, Renaud Mazeron
PURPOSE: With the increasing use of simultaneous integrated boost in the treatment of cervical cancer, there is a need to anticipate the brachytherapy (BT) contribution at the level of the pathologic pelvic lymph nodes. This study aimed to report the dose delivered at their level during BT. METHODS AND MATERIALS: Patients with pelvic nodal involvement and treated with a combination of chemoradiation followed by image-guided adaptive pulsed-dose-rate BT were selected...
January 31, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28117611/long-term-outcomes-of-intensity-modulated-radiotherapy-following-extra-pleural-pneumonectomy-for-malignant-pleural-mesothelioma
#10
Yukinori Matsuo, Keiko Shibuya, Kenichi Okubo, Nami Ueki, Akihiro Aoyama, Makoto Sonobe, Mitsuhiro Nakamura, Takashi Mizowaki, Hiroshi Date, Masahiro Hiraoka
BACKGROUND: The purpose was to evaluate safety and efficacy of intensity-modulated radiotherapy (IMRT) following extra-pleural pneumonectomy (EPP) for malignant pleural mesothelioma (MPM). MATERIAL AND METHODS: Patients with MPM of clinical stage I-III, which were macroscopic completely resected with EPP were eligible for this prospective study. The ipsilateral hemithorax was irradiated with a prescribed dose of 50.4 Gy. When the high-risk surgical margins or FDG-avid regions were identified, simultaneous integrated boost (SIB) with 56...
January 24, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28111423/induction-chemotherapy-with-gemcitabine-and-cisplatin-followed-by-simultaneous-integrated-boost-intensity-modulated-radiotherapy-with-concurrent-gemcitabine-for-locally-advanced-unresectable-pancreatic-cancer-results-from-a-feasibility-study
#11
Sang Myung Woo, Min Kyeong Kim, Jungnam Joo, Kyong-Ah Yoon, Boram Park, Sang-Jae Park, Sung-Sik Han, Ju Hee Lee, Eun Kyung Hong, Yun-Hee Kim, Hae Moon, Sun-Young Kong, Tae Hyun Kim, Woo Jin Lee
Purpose: This study assessed the feasibility and compliance of induction chemotherapy with gemcitabine and cisplatin followed by simultaneous integrated boost-intensity modulated radiotherapy (SIB-IMRT) with concurrent gemcitabine in patients with locally advanced unresectable pancreatic cancer (LAPC). Materials and Methods: In this trial, patients received induction chemotherapy consisting of gemcitabine (1000 mg/m2) and cisplatin (25 mg/m2) on days 1, 8 and 15 of each treatment cycle...
January 19, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28103970/-a-phase-i-ii-study-of-chemotherapy-concurrent-with-twice-daily-radiotherapy-%C3%A2-schedules-by-intensity-modulated-radiation-therapy-using-simultaneous-integrated-boost-for-limited-stage-small-cell-lung-cancer
#12
Jing You, Huiming Yu, Maxiaowei Song, Chen Shi, Xiaohang Wang, Ye Zheng, Rong Yu, Anhui Shi, Guangying Zhu
BACKGROUND: Twice-daily radiation concurrent with chemotherapy is one of the standard methods for limited-stage small cell lung cancer. The study was to evaluate the feasibility of chemotherapy concurrent with dose-escalating twice-daily radiotherapy by simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) approach in patients with limited-stage small cell lung cancer. METHODS: Patients with limited-stage small cell lung cancer were included, treated with twice-daily radiotherapy by SIB-IMRT concurrent with chemotherapy of etoposide plus cisplatin...
January 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28089762/long-terms-results-of-a-trial-of-concurrent-chemotherapy-and-escalating-doses-of-radiation-for-unresectable-non-small-cell-lung-cancer-ncctg-n0028-alliance
#13
Steven E Schild, Shauna L Hillman, Angelina D Tan, Helen J Ross, William L McGinnis, Yolanda A Garces, David L Graham, Alex A Adjei, James R Jett
INTRODUCTION OR HYPOTHESIS: This phase I/II trial was originally designed to determine the maximally tolerated dose(MTD) of thoracic radiotherapy(TRT) as part of a combined modality approach. This report includes the long-term outcome of patients treated on this study. The phase II portion was never completed as RTOG-0617 opened before it was concluded. METHODS: The MTD was defined as 74Gy in 37 fractions in this study. Twenty-five patients with unresectable non-small cell lung cancer(NSCLC) were treated with 2Gy daily fractions and concurrent weekly carboplatin and paclitaxel...
January 12, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28086954/a-comparative-analysis-between-sequential-boost-and-integrated-boost-intensity-modulated-radiation-therapy-with-concurrent-chemotherapy-for-locally-advanced-head-and-neck-cancer
#14
Gregory Vlacich, Mark J Stavas, Praveen Pendyala, Shaeu-Chiann Chen, Yu Shyr, Anthony J Cmelak
BACKGROUND: Planning and delivery of IMRT for locally advanced head and neck cancer (LAHNC) can be performed using sequential boost or simultaneous integrated boost (SIB). Whether these techniques differ in treatment-related outcomes including survival and acute and late toxicities remain largely unexplored. METHODS: We performed a single institutional retrospective matched cohort analysis on patients with LAHNC treated with definitive chemoradiotherapy to 69.3 Gy in 33 fractions...
January 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28062087/does-an-integrated-boost-increase-acute-toxicity-in-prone-hypofractionated-breast-irradiation-a-randomized-controlled-trial
#15
Leen Paelinck, Akos Gulyban, Ferenc Lakosi, Tom Vercauteren, Werner De Gersem, Bruno Speleers, Christel Monten, Thomas Mulliez, Patrick Berkovic, Annick van Greveling, Frederik Decoster, Philippe Coucke, Wilfried De Neve, Liv Veldeman
BACKGROUND AND PURPOSE: The safety of a simultaneous integrated boost (SIB) in combination with prone hypofractionated whole-breast irradiation (WBI) was investigated. MATERIALS AND METHODS: 167 patients were randomized between WBI with a sequential boost (SeB) or SIB. All patients were treated in prone position to 40.05Gy in 15 fractions to the whole breast. In the control arm, a SeB of 10Gy in 4 fractions (negative surgical margins) or 14.88Gy in 6 fractions (transsection) was prescribed...
January 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28048927/mo-fg-bra-05-dosimetric-and-radiobiological-validation-of-respiratory-gating-in-conventional-and-hypofractionated-radiotherapy-of-the-lung-effect-of-dose-dose-rate-gating-window-and-breathing-pattern
#16
L Cervino, D Soultan, N Pettersson, A Yock, M Cornell, J Aguilera, J Murphy, B Gill, S Advani, V Moiseenko
PURPOSE: to evaluate the dosimetric and radiobiological consequences from having different gating windows, dose rates, and breathing patterns in gated VMAT lung radiotherapy. METHODS: A novel 3D-printed moving phantom with central high and peripheral low tracer uptake regions was 4D FDG-PET/CT-scanned using ideal, patient-specific regular, and irregular breathing patterns. A scan of the stationary phantom was obtained as a reference. Target volumes corresponding to different uptake regions were delineated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048890/su-g-tep1-05-development-and-clinical-introduction-of-automated-radiotherapy-treatment-planning-for-prostate-cancer
#17
D Winkel, G H Bol, B van Asselen, J Hes, V Scholten, Lgw Kerkmeijer, B W Raaymakers
PURPOSE: To develop an automated radiotherapy treatment planning and optimization workflow for prostate cancer in order to generate clinical treatment plans. METHODS: A fully automated radiotherapy treatment planning and optimization workflow was developed based on the treatment planning system Monaco (Elekta AB, Stockholm, Sweden). To evaluate our method, a retrospective planning study (n=100) was performed on patients treated for prostate cancer with 5 field intensity modulated radiotherapy, receiving a dose of 35×2Gy to the prostate and vesicles and a simultaneous integrated boost of 35×0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048574/su-f-t-349-dosimetric-comparison-of-three-different-simultaneous-integrated-boost-irradiation-techniques-for-multiple-brain-metastases-intensity-modulatedradiotherapy-hybrid-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-therapy
#18
X Lin, T Sun, Y Yin
PURPOSE: To study the dosimetric impact of intensity-modulated radiotherapy (IMRT), hybrid intensity-modulated radiotherapy (h-IMRT) and volumetric modulated arc therapy(VMAT) for whole-brain radiotherapy (WBRT) with simultaneous integrated boost in patients with multiple brain metastases. METHODS: Ten patients with multiple brain metastases were included in this analysis. The prescribed dose was 45 Gy to the whole brain (PTVWBRT) and 55 Gy to individual brain metastases (PTVboost) delivered simultaneously in 25 fractions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048516/su-f-e-03-pet-ct-guided-dose-boost-to-hypoxic-sub-volume-in-nasopharyngeal-carcinomas-using-self-optimizing-non-uniform-vmat
#19
J Qiu, X Zheng, H Liu, B Chen, W Zhuo
PURPOSE: This study is to evaluate the feasibility of simultaneously integrated boost (SIB) to hypoxic subvolume (HTV) in nasopharyngeal carcinomas under the guidance of 18F-Fluoromisonidazole (FMISO) PET/CT using a novel non-uniform volumetric modulated arc therapy (VMAT)technique. METHODS: Eight nasopharyngeal carcinoma patients treated with conventional uniform VMAT were retrospectively analyzed. For each treatment, actual conventional uniform VMAT plan with two or more arcs (2-2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047766/su-c-202-04-adapting-biologically-optimized-dose-escalation-based-on-mid-treatment-pet-ct-for-non-small-cell-lung-cancer
#20
P Zhang, L Kuo, E Yorke, Y Hu, N Lockney, G Mageras, J Deasy, A Rimner
PURPOSE: To develop a biological modeling strategy which incorporates the response observed on the mid-treatment PET/CT into a dose escalation design for adaptive radiotherapy of non-small-cell lung cancer. METHOD: FDG-PET/CT was acquired midway through standard fractionated treatment and registered to pre-treatment planning PET/CT to evaluate radiation response of lung cancer. Each mid-treatment PET voxel was assigned the median SUV inside a concentric 1cm-diameter sphere to account for registration and imaging uncertainties...
June 2016: Medical Physics
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