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Simultaneous integrated boost

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https://www.readbyqxmd.com/read/28086954/a-comparative-analysis-between-sequential-boost-and-integrated-boost-intensity-modulated-radiation-therapy-with-concurrent-chemotherapy-for-locally-advanced-head-and-neck-cancer
#1
Gregory Vlacich, Mark J Stavas, Praveen Pendyala, Shaeu-Chiann Chen, Yu Shyr, Anthony J Cmelak
BACKGROUND: Planning and delivery of IMRT for locally advanced head and neck cancer (LAHNC) can be performed using sequential boost or simultaneous integrated boost (SIB). Whether these techniques differ in treatment-related outcomes including survival and acute and late toxicities remain largely unexplored. METHODS: We performed a single institutional retrospective matched cohort analysis on patients with LAHNC treated with definitive chemoradiotherapy to 69.3 Gy in 33 fractions...
January 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28062087/does-an-integrated-boost-increase-acute-toxicity-in-prone-hypofractionated-breast-irradiation-a-randomized-controlled-trial
#2
Leen Paelinck, Akos Gulyban, Ferenc Lakosi, Tom Vercauteren, Werner De Gersem, Bruno Speleers, Christel Monten, Thomas Mulliez, Patrick Berkovic, Annick van Greveling, Frederik Decoster, Philippe Coucke, Wilfried De Neve, Liv Veldeman
BACKGROUND AND PURPOSE: The safety of a simultaneous integrated boost (SIB) in combination with prone hypofractionated whole-breast irradiation (WBI) was investigated. MATERIALS AND METHODS: 167 patients were randomized between WBI with a sequential boost (SeB) or SIB. All patients were treated in prone position to 40.05Gy in 15 fractions to the whole breast. In the control arm, a SeB of 10Gy in 4 fractions (negative surgical margins) or 14.88Gy in 6 fractions (transsection) was prescribed...
January 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28048927/mo-fg-bra-05-dosimetric-and-radiobiological-validation-of-respiratory-gating-in-conventional-and-hypofractionated-radiotherapy-of-the-lung-effect-of-dose-dose-rate-gating-window-and-breathing-pattern
#3
L Cervino, D Soultan, N Pettersson, A Yock, M Cornell, J Aguilera, J Murphy, B Gill, S Advani, V Moiseenko
PURPOSE: to evaluate the dosimetric and radiobiological consequences from having different gating windows, dose rates, and breathing patterns in gated VMAT lung radiotherapy. METHODS: A novel 3D-printed moving phantom with central high and peripheral low tracer uptake regions was 4D FDG-PET/CT-scanned using ideal, patient-specific regular, and irregular breathing patterns. A scan of the stationary phantom was obtained as a reference. Target volumes corresponding to different uptake regions were delineated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048890/su-g-tep1-05-development-and-clinical-introduction-of-automated-radiotherapy-treatment-planning-for-prostate-cancer
#4
D Winkel, G H Bol, B van Asselen, J Hes, V Scholten, Lgw Kerkmeijer, B W Raaymakers
PURPOSE: To develop an automated radiotherapy treatment planning and optimization workflow for prostate cancer in order to generate clinical treatment plans. METHODS: A fully automated radiotherapy treatment planning and optimization workflow was developed based on the treatment planning system Monaco (Elekta AB, Stockholm, Sweden). To evaluate our method, a retrospective planning study (n=100) was performed on patients treated for prostate cancer with 5 field intensity modulated radiotherapy, receiving a dose of 35×2Gy to the prostate and vesicles and a simultaneous integrated boost of 35×0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048574/su-f-t-349-dosimetric-comparison-of-three-different-simultaneous-integrated-boost-irradiation-techniques-for-multiple-brain-metastases-intensity-modulatedradiotherapy-hybrid-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-therapy
#5
X Lin, T Sun, Y Yin
PURPOSE: To study the dosimetric impact of intensity-modulated radiotherapy (IMRT), hybrid intensity-modulated radiotherapy (h-IMRT) and volumetric modulated arc therapy(VMAT) for whole-brain radiotherapy (WBRT) with simultaneous integrated boost in patients with multiple brain metastases. METHODS: Ten patients with multiple brain metastases were included in this analysis. The prescribed dose was 45 Gy to the whole brain (PTVWBRT) and 55 Gy to individual brain metastases (PTVboost) delivered simultaneously in 25 fractions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048516/su-f-e-03-pet-ct-guided-dose-boost-to-hypoxic-sub-volume-in-nasopharyngeal-carcinomas-using-self-optimizing-non-uniform-vmat
#6
J Qiu, X Zheng, H Liu, B Chen, W Zhuo
PURPOSE: This study is to evaluate the feasibility of simultaneously integrated boost (SIB) to hypoxic subvolume (HTV) in nasopharyngeal carcinomas under the guidance of 18F-Fluoromisonidazole (FMISO) PET/CT using a novel non-uniform volumetric modulated arc therapy (VMAT)technique. METHODS: Eight nasopharyngeal carcinoma patients treated with conventional uniform VMAT were retrospectively analyzed. For each treatment, actual conventional uniform VMAT plan with two or more arcs (2-2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047766/su-c-202-04-adapting-biologically-optimized-dose-escalation-based-on-mid-treatment-pet-ct-for-non-small-cell-lung-cancer
#7
P Zhang, L Kuo, E Yorke, Y Hu, N Lockney, G Mageras, J Deasy, A Rimner
PURPOSE: To develop a biological modeling strategy which incorporates the response observed on the mid-treatment PET/CT into a dose escalation design for adaptive radiotherapy of non-small-cell lung cancer. METHOD: FDG-PET/CT was acquired midway through standard fractionated treatment and registered to pre-treatment planning PET/CT to evaluate radiation response of lung cancer. Each mid-treatment PET voxel was assigned the median SUV inside a concentric 1cm-diameter sphere to account for registration and imaging uncertainties...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047620/th-cd-207a-12-impacts-of-inter-and-intra-fractional-organ-motion-for-high-risk-prostate-cancer-stereotactic-body-radiation-therapy
#8
N Hassan Rezaeian, Y Chi, Y Zhou, Z Tian, S Jiang, R Hannan, X Jia
PURPOSE: We are conducting a clinical trial on stereotactic body radiation therapy (SBRT) for high-risk prostate cancer. Doses to three targets, prostate, intra-prostatic lesion, and pelvic lymph node (PLN) region, are escalated to three different levels via simultaneous integrated boost technique. Inter-/intra-fractional organ motions deteriorate planned dose distribution. This study aims at developing a dose reconstruction system to comprehensively understand the impacts of organ motion in our clinical trial...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047592/su-g-tep1-07-investigation-of-rapidplan-based-plan-quality-for-breast-imrtsimultaneously-integrated-boost
#9
J Wang, W Hu, X Chen, Z Wu
PURPOSE: The aim of this study is to investigate the feasibility of using RapidPlan for breast cancer radiotherapy and to evaluate its performance for planners with different planning experiences. METHODS: A training database was collected with 80 expert plan datasets from patients previously received left breast conserving surgery and IMRT-simultaneously integrated boost radiotherapy. The models were created on the RapidPlan. Five patients from the training database and 5 external patients were used for internal and external validation, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047094/we-ab-202-10-modelling-individual-tumor-specific-control-probability-for-hypoxia-in-rectal-cancer
#10
S Warren, D R Warren, J M Wilson, R Muirhead, M A Hawkins, T Maughan, M Partridge
PURPOSE: To investigate hypoxia-guided dose-boosting for increased tumour control and improved normal tissue sparing using FMISO-PET images METHODS: Individual tumor-specific control probability (iTSCP) was calculated using a modified linear-quadratic model with rectal-specific radiosensitivity parameters for three limiting-case assumptions of the hypoxia / FMISO uptake relationship. (18) FMISO-PET images from 2 patients (T3N0M0) from the RHYTHM trial (Investigating Hypoxia in Rectal Tumours NCT02157246) were chosen to delineate a hypoxic region (GTV_MISO defined as tumor-to-muscle ratio > 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047088/su-g-brc-09-experimental-validation-of-a-vmat-planning-technique-for-patients-with-hip-prosthesis
#11
M Milette, L Sporn, M Robinson
PURPOSE: To validate and evaluate the dosimetric accuracy of two different VMAT planning techniques for patients with hip prosthesis of unknown composition. METHODS: A phantom was designed to model a patient with one stainless steel hip prosthesis. PTVs and critical structures contours were copied from a prostate cancer patient. Simultaneous integrated boost VMAT plans covering the prostate and pelvic lymph nodes (50.4Gy and 70Gy in 28 fractions) and sparing the rectum and bladder were generated in Eclipse using AAA dose calculation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046785/su-f-j-173-online-replanning-for-dose-painting-based-on-changing-adc-map-of-pancreas-cancer
#12
O Ates, E Ahunbay, B Erickson, X Li
PURPOSE: The introduction of MR-guided radiation therapy (RT), e.g., MR-Linac, would allow dose painting to adapt spatial RT response revealed from MRI data during the RT delivery. The purpose of this study is to investigate the use of an online replanning method to adapt dose painting from the MRI Apparent Diffusion Coefficient (ADC) map acquired during the delivery of RT for pancreatic cancers. METHODS: Original dose painting plans were created based on multi-parametric simulation MRI including T1, T2 and ADC, using a treatment planning system (MONACO, Elekta) equipped with an online replanning algorithm (WSO, warm start optimization)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046578/su-f-t-392-superior-brainstem-and-cochlea-sparing-with-vmat-for-glioblastoma-multiforme
#13
T M Briere, M F McAleer, L B Levy, J N Yang, M D Anderson
PURPOSE: Volumetric arc therapy (VMAT) can provide similar target coverage and normal tissue sparing as IMRT but with shorter treatment times. At our institution VMAT was adopted for the treatment glioblastoma multiforme (GBM) after a small number of test plans demonstrated its non-inferiority. In this study, we compare actual clinical treatment plans for a larger cohort of patients treated with either VMAT or IMRT. METHODS: 90 GBM patients were included in this study, 45 treated with IMRT and 45 with VMAT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046443/su-f-t-498-a-comparative-evaluation-of-6mv-flatten-beam-and-flattening-filter-free-photon-beam-in-carcinoma-breast
#14
Suresh Tamilarasu, Madeswaran Saminathan
PURPOSE: Aim of the current study is to look plan quality, treatment beam ON time for IMRT using 6MV FB (Flatten Beam) and FFFB (Flattening Filter Free Beam) in left breast cancer cases. METHODS: Ten left breast cancer patients treated with breast conserving surgical (BCS) procedure approach and adjuvant radiotherapy were selected from the department database. Simultaneous Integrated boost (SIB) technique was used to irradiate the total left breast (PTV) to a dose of 50...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046304/su-f-t-597-modeling-and-evaluation-of-rapidplan-for-simultaneous-integrated-boost-npc-cases
#15
F Chang, P Wang, P Tsai, S Lee, C Yeh, K Fan, J Chang
PURPOSE: The evaluation of using RapidPlan to generate the model of simultaneous integrated boost (SIB) VMAT plans for nasopharyngeal carcinoma (NPC). METHODS: In this study, the training models were established for SIB NPC cases in RadpidPlan system. The knowledge database was created from 46 VMAT plans for NPC with two dose level targets. CTV212 received 69.96 Gy in 33 fractions at 2.12 Gy per fraction. PTV164 received 54.12 Gy at 1.64 Gy per fraction. To validate the models, we generated plans with model-estimated objectives on four new NPC cases that were not included in the model-training database...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034680/implementation-of-intensity-modulated-radiotherapy-for-head-and-neck-cancers-in-routine-practice
#16
C Bednarek, T V F Nguyen, M Puyraveau, É Bonnet, N Lescut, C Azélie, J Miny, O Mauvais, T Maurina, F Tochet, J-F Bosset, J Thariat, X S Sun
PURPOSE: To report on patterns of relapse following implementation of intensity-modulated radiotherapy and subsequent changes in practice in a tertiary care centre. PATIENTS AND METHODS: Between 2008 and 2011, 188 consecutive patients (mean age 59 years old) received intensity-modulated radiotherapies with curative intent for squamous cell carcinomas of the oral cavity (17.5%), oropharynx (43%), hypopharynx (21%), larynx (14%), sinonasal cavities (6%), nasopharynx (1...
December 26, 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28034460/risk-adapted-simultaneous-integrated-boost-proton-beam-therapy-sib-pbt-for-advanced-hepatocellular-carcinoma-with-tumour-vascular-thrombosis
#17
Dae Yong Kim, Joong-Won Park, Tae Hyun Kim, Bo Hyun Kim, Sung Ho Moon, Sang Soo Kim, Sang Myung Woo, Young-Hwan Koh, Woo Jin Lee, Chang-Min Kim
PURPOSE: To evaluate clinical effectiveness and safety of simultaneous integrated boost-proton beam therapy (SIB-PBT) in hepatocellular carcinoma (HCC) patients with tumour vascular thrombosis (TVT). MATERIAL AND METHODS: Forty-one HCC patients with TVT underwent SIB-PBT using three dose-fractionation schemes: if gross tumour volume <1cm (n=27), 1-1.9cm (n=7), and ⩾2cm (n=7) from gastrointestinal structures, 50GyE (EQD2, 62.5GyE10), 60Gy (EQD2, 80GyE10), 66Gy (EQD2, 91...
December 26, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27935952/neoadjuvant-gemcitabine-chemotherapy-followed-by-concurrent-imrt-simultaneous-boost-achieves-high-r0-resection-in-borderline-resectable-pancreatic-cancer-patients
#18
Xiaolun Huang, Jeanna L Knoble, Ming Zeng, Fernando N Aguila, Tara Patel, Lowell W Chambers, Honglin Hu, Hao Liu
BACKGROUND: To study the feasibility of down stage the borderline resectable pancreatic cancer (BRPC) to resectable disease, we reported our institutional results using an intensity-modulated radiation therapy (IMRT) simultaneous integrated boost (SIB) dose escalation approach to improve R0 resectability. METHODS: We reviewed our past 7 years of experience of using neoadjuvant induction chemotherapy with Gemcitabine followed by concurrent chemoradiaiton for BRPC...
2016: PloS One
https://www.readbyqxmd.com/read/27929483/a-dosimetric-evaluation-of-knowledge-based-vmat-planning-with-simultaneous-integrated-boosting-for-rectal-cancer-patients
#19
Hao Wu, Fan Jiang, Haizhen Yue, Sha Li, Yibao Zhang
RapidPlan, a commercial knowledge-based optimizer, has been tested on head and neck, lung, esophageal, breast, liver, and prostate cancer patients. To appraise its performance on VMAT planning with simultaneous integrated boosting (SIB) for rectal cancer, this study configured a DVH (dose-volume histogram) estimation model consisting 80 best-effort manual cases of this type. Using the model-generated objectives, the MLC (multileaf collimator) sequences of other 70 clinically approved plans were reoptimized, while the remaining parameters, such as field geometry and photon energy, were maintained...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27896797/a-telephone-based-intervention-to-promote-physical-activity-during-smoking-cessation-a-randomized-controlled-proof-of-concept-study
#20
Uma S Nair, Freda Patterson, Daniel Rodriguez, Bradley N Collins
Smoking and physical inactivity contribute to disproportionate disease burden among underserved adults. Telephone-based interventions (quitlines) are becoming the standard care for addressing smoking. There is increasing interest to determine whether quitlines can be utilized to administer interventions for other unhealthy behaviors. This study aims to examine the proof-of-concept and potential efficacy of a telephone-based behavioral counseling intervention to boost daily low-to-moderate physical activity among low-income, physically inactive smokers...
November 28, 2016: Translational Behavioral Medicine
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