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Simultaneous integrated boost

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https://www.readbyqxmd.com/read/29789766/salvage-high-dose-rate-brachytherapy-for-prostate-cancer-persistence-after-brachytherapy-repeated-use-of-a-polyethylene-glycol-hydrogel-spacer
#1
Rodrigo Hepp, Thilo Eggert, Georg Schabl, Lars Herberholz, Tim Petry, Razvan Galalae
Purpose: The aim of this study is to determine if a repeated hydrogel injection in a previously irradiated patient prior to salvage high-dose-rate brachytherapy (HDR-BT) is feasible. Material and methods: A 61-year-old man with an organ confined (cT1c cN0 cM0, Gleason score 3 + 3 = 6, initial prostate-specific antigen [PSA] 7.9 ng/ml) prostate cancer was previously treated with HDR-BT (3 fractions of 11.5 Gy every 2nd week) after hydrogel injection to reduce the rectal dose...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29785183/evaluation-of-reirradiation-in-locally-advanced-head-and-neck-cancers-toxicity-and-early-clinical-outcomes
#2
Amit Bahl, Arun Singh Oinam, Arun Elangovan, Satinder Kaur, Gaurav Trivedi, Roshan Verma, Sudhir Bhandari, Sushmita Ghoshal, Naresh Kumar Panda
Objectives: Locoregional recurrence is the predominant pattern of treatment failure in advanced head and neck cancers. Reirradiation is a useful modality to treat inoperable head and neck cancer patients with recurrent disease. The aim of the present study was to analyze the treatment toxicity and early clinical outcomes in patients undergoing reirradiation. Methods: Twenty patients of head and neck cancers with recurrences or second cancers were evaluated. Reirradiation was done using simultaneous integrated boost volumetric modulated arc therapy (SIB VMAT), intensity modulated radiotherapy (IMRT), or conventional radiotherapy using 6MV photons...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29761987/-comparison-of-planning-quality-and-delivery-efficiency-between-volumetric-modulated-arc-therapy-and-dynamic-intensity-modulated-radiation-therapy-for-nasopharyngeal-carcinoma-with-more-than-4-prescribed-dose-levels
#3
Pengfei Jia, Jun Xu, Xiaoxi Zhou, Jian Chen, Lemin Tang
The aim of this study is to compare the planning quality and delivery efficiency between dynamic intensity modulated radiation therapy (d-IMRT) and dual arc volumetric modulated arc therapy (VMAT) systematically for nasopharyngeal carcinoma (NPC) patients with multi-prescribed dose levels, and to analyze the correlations between target volumes and plan qualities. A total of 20 patients of NPC with 4-5 prescribed dose levels to achieve simultaneous integrated boost (SIB) treated by sliding window d-IMRT in our department from 2014 to 2015 were re-planned with dual arc VMAT...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29761663/a-prospective-pilot-study-on-early-toxicity-from-a-simultaneously-integrated-boost-technique-for-canine-sinonasal-tumours-using-image-guided-intensity-modulated-radiation-therapy
#4
A Soukup, V Meier, S Pot, K Voelter, C Rohrer Bley
In order to overcome the common local treatment failure of canine sinonasal tumours, integrated boost techniques were tried in the cobalt/orthovoltage era, but dismissed because of unacceptable early (acute) toxicity. Intriguingly, a recent calculation study of a simultaneously integrated boost (SIB) technique for sinonasal irradiation using intensity-modulated radiation therapy (IMRT) predicted theoretical feasibility. In this prospective pilot study we applied a commonly used protocol of 10 × 4.2 Gy to the planning target volume (PTV) with a 20%-SIB dose to the gross tumour volume (GTV)...
May 14, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29758479/move-to-learn-integrating-spatial-information-from-multiple-viewpoints
#5
Corinne A Holmes, Nora S Newcombe, Thomas F Shipley
Recalling a spatial layout from multiple orientations - spatial flexibility - is challenging, even when the global configuration can be viewed from a single vantage point, but more so when it must be viewed piecemeal. In the current study, we examined whether experiencing the transition between multiple viewpoints enhances spatial memory and flexible recall for a spatial configuration viewed simultaneously (Exp. 1) and sequentially (Exp. 2), whether the type of transition matters, and whether action provides an additional advantage over passive experience...
May 11, 2018: Cognition
https://www.readbyqxmd.com/read/29750539/short-term-high-precision-radiotherapy-for-early-prostate-cancer-with-concomitant-boost-to-the-dominant-lesion-ad-interim-analysis-and-preliminary-results-of-phase-ii-trial-airc-ig-13218
#6
Giorgia Timon, Delia Ciardo, Alessia Bazani, Giulia Marvaso, Giulia Riva, Stefania Volpe, Stefania Volpe, Giuseppe Renne, Giuseppe Petralia, Dario Zerini, Damaris Patricia Rojas, Samantha Dicuonzo, Davide Maestri, Floriana Pansini, Raffaella Cambria, Cristiana Fodor, Federica Cattani, Federica Golino, Valerio Scroffi, Daniela De Lorenzo, Ottavio De Cobelli, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
OBJECTIVE: To report preliminary results of a cutting edge extreme hypofractionated treatment with concomitant boost to the dominant lesion for patients with early stage prostate cancer (PCa). METHODS: AIRC-IG-13218 is a prospective phase II trial started in June 2015. Patients with low and intermediate risk PCa who met the inclusion criteria underwent extreme hypofractionated radiotherapy to the prostate (36.25 Gy in 5 fractions) and a simultaneous integrated boost to the dominant intraprostatic lesion (DIL) to 37...
May 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29750261/validation-of-previously-reported-predictors-for-radiation-induced-hypothyroidism-in-nasopharyngeal-cancer-patients-treated-with-intensity-modulated-radiation-therapy-a-post-hoc-analysis-from-a-phase-iii-randomized-trial
#7
Chawalit Lertbutsayanukul, Sarin Kitpanit, Anussara Prayongrat, Danita Kannarunimit, Buntipa Netsawang, Chakkapong Chakkabat
This study aimed to validate previously reported dosimetric parameters, including thyroid volume, mean dose, and percentage thyroid volume, receiving at least 40, 45 and 50 Gy (V40, V45 and V50), absolute thyroid volume spared (VS) from 45, 50 and 60 Gy (VS45, VS50 and VS60), and clinical factors affecting the development of radiation-induced hypothyroidism (RHT). A post hoc analysis was performed in 178 euthyroid nasopharyngeal cancer (NPC) patients from a Phase III study comparing sequential versus simultaneous-integrated boost intensity-modulated radiation therapy...
May 10, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29720197/the-prognostic-role-of-hemoglobin-levels-in-patients-undergoing-concurrent-chemo-radiation-for-anal-cancer
#8
Pierfrancesco Franco, Francesco Montagnani, Francesca Arcadipane, Chiara Casadei, Kalliopi Andrikou, Stefania Martini, Giuseppe Carlo Iorio, Mario Scartozzi, Massimiliano Mistrangelo, Lorenzo Fornaro, Paola Cassoni, Stefano Cascinu, Umberto Ricardi, Andrea Casadei Gardini
BACKGROUND: Concurrent chemo-radiation (CT-RT) is a standard therapy for squamous cell carcinoma of anal canal. Different clinical and biological factors may potentially affect outcome. We investigated the prognostic role of baseline hemoglobin (Hb) in a cohort of anal cancer patients submitted to CT-RT with 5-fluorouracil and mitomycin C. METHODS: Up to 161 patients with clinical stage T1-T4/N0-N3/M0 were treated. Response was assessed at 6 weeks and thereafter at 3, 6 and 12 months...
May 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29713707/enhancing-circular-dichroism-by-chiral-hotspots-in-silicon-nanocube-dimers
#9
Kan Yao, Yongmin Liu
Circular dichroism (CD) spectroscopy, which measures the differential absorption of circularly polarized light with opposite handedness, is an important technique to detect and identify chiral molecules in chemistry, biology and life sciences. However, CD signals are normally very small due to the intrinsically weak chirality of molecules. Here we theoretically investigate the generation of chiral hotspots in silicon nanocube dimers for CD enhancement. Up to 15-fold enhancement of the global optical chirality is obtained in the dimer gap, which boosts the CD signal by one order of magnitude without reducing the dissymmetry factor...
May 1, 2018: Nanoscale
https://www.readbyqxmd.com/read/29706108/the-use-of-a-simultaneous-integrated-boost-in-spinal-stereotactic-body-radiotherapy-to-reduce-the-risk-of-vertebral-compression-fractures-a-treatment-planning-study
#10
Joanne M van der Velden, Jochem Hes, Arjun Sahgal, Stan J Hoogcarspel, Marielle E P Philippens, Wietse S C Eppinga, Enrica Seravalli
No abstract text is available yet for this article.
April 28, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29699635/definite-intensity-modulated-radiotherapy-with-concurrent-chemotherapy-more-than-4-cycles-improved-survival-for-patients-with-locally-advanced-or-inoperable-esophageal-squamous-cell-carcinoma
#11
He-Yuan Hsieh, Chung-Ping Hsu, Hui-Ling Yeh, Cheng-Yen Chuang, Jai-Fu Lin, Chen-Fa Chang
We investigated which prognostic factor could improve survival for esophageal cancer patients who received definite concurrent chemoradiation (CCRT). Eighty patients with age ≥18, Karnofsky Performance Scale (KPS) ≥ 60, and clinical stage T1-4N0-3M0 esophageal squamous cell carcinoma were enrolled from July 2004 to December 2015. They underwent definite intensity-modulated radiotherapy (IMRT) with or without simultaneous integrated boost to the primary tumor, and reception of concurrent chemotherapy ≥ 1 cycle...
May 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29666802/advances-in-radiotherapy-for-esophageal-cancer
#12
REVIEW
Wei Deng, Steven H Lin
Esophageal cancer is a common type of malignancy worldwide and usually requires multidisciplinary care. Radiotherapy plays an important part in management of the disease. During the past few years, researchers have made much progress about radiotherapy for esophageal cancer, which was revealed in every aspect of clinical practice. Neoadjuvant chemoradiotherapy remains the standard treatment for locally advanced esophageal cancer, whereas neoadjuvant chemotherapy appears to show less toxicities and non-inferior prognosis...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29664354/combined-taxane-based-chemotherapy-and-intensity-modulated-radiotherapy-with-simultaneous-integrated-boost-for-gastroesophageal-junction-adenocarcinoma
#13
Corrado Spatola, Alessandra Tocco, Antonio Pagana, Roberto Milazzotto, Raffaele Luigi, Vincenzo Salamone, Carmelo Militello, Marcello Migliore, Pietro Valerio Foti, Antonio Di Cataldo, Grazia Acquaviva, Giuseppe Privitera
We describe our experience, gained over the past 3 years, in the treatment of gastroesophageal junction adenocarcinoma, whose incidence has been increasing in recent years. In our series, we present the results to a follow-up of about 2 years for a total of 18 patients, treated with a particularly intensive combination treatment. It consists of neoadjuvant induction chemotherapy with the protocol docetaxel-cisplatin-5-fluorouracil for four cycles, before a concomitant chemoradiotherapy treatment. During combined phase, patients received an intensity-modulated radiotherapy and a weekly cisplatin...
March 2018: Future Oncology
https://www.readbyqxmd.com/read/29648867/learning-of-pitch-and-time-structures-in-an-artificial-grammar-setting
#14
Jon B Prince, Catherine J Stevens, Mari Riess Jones, Barbara Tillmann
Despite the empirical evidence for the power of the cognitive capacity of implicit learning of structures and regularities in several modalities and materials, it remains controversial whether implicit learning extends to the learning of temporal structures and regularities. We investigated whether (a) an artificial grammar can be learned equally well when expressed in duration sequences as when expressed in pitch sequences, (b) learning of the artificial grammar in either duration or pitch (as the primary dimension) sequences can be influenced by the properties of the secondary dimension (invariant vs...
April 12, 2018: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/29623584/dosimetry-study-of-18-f-fmiso-pet-ct-hypoxia-imaging-guidance-on-intensity-modulated-radiation-therapy-for-non-small-cell-lung-cancer
#15
H Li, D Xu, X Han, Q Ruan, X Zhang, Y Mi, M Dong, S Guo, Y Lin, B Wang, G Li
OBJECTIVES: This study was to evaluate the feasibility of simultaneous integrated boost on tumor hypoxia area by studying the dosimetric change of hypoxia imaging guidance on intensity-modulated radiation therapy for non-small cell lung cancer (NSCLC). METHODS: Five NSCLC patients with large hypoxic volume participated in this study. FDG PET/CT images were fused with CT localization images to delineate gross tumor volume. FMISO PET/CT images were fused with CT localization images to delineate hypoxic biological target volume (BTV) (tissue maximum ratio ≥ 1...
April 5, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29607452/haa1-and-prs3-overexpression-boosts-yeast-tolerance-towards-acetic-acid-improving-xylose-or-glucose-consumption-unravelling-the-underlying-mechanisms
#16
Joana T Cunha, Carlos E Costa, Luís Ferraz, Aloia Romaní, Björn Johansson, Isabel Sá-Correia, Lucília Domingues
Acetic acid tolerance and xylose consumption are desirable traits for yeast strains used in industrial biotechnological processes. In this work, overexpression of a weak acid stress transcriptional activator encoded by the gene HAA1 and a phosphoribosyl pyrophosphate synthetase encoded by PRS3 in a recombinant industrial Saccharomyces cerevisiae strain containing a xylose metabolic pathway was evaluated in the presence of acetic acid in xylose- or glucose-containing media. HAA1 or PRS3 overexpression resulted in superior yeast growth and higher sugar consumption capacities in the presence of 4 g/L acetic acid, and a positive synergistic effect resulted from the simultaneous overexpression of both genes...
April 2, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29578113/passive-magnetic-shielding-in-mri-linac-systems
#17
Brendan Whelan, Stefan Kolling, Brad M Oborn, Paul Keall
Passive magnetic shielding refers to the use of ferromagnetic materials to redirect magnetic field lines away from vulnerable regions. An application of particular interest to the medical physics community is shielding in MRI systems, especially integrated MRI-linear accelerator (MRI-Linac) systems. In these systems, the goal is not only to minimize the magnetic field in some volume, but also to minimize the impact of the shield on the magnetic fields within the imaging volume of the MRI scanner. In this work, finite element modelling was used to assess the shielding of a side coupled 6 MV linac and resultant heterogeneity induced within the 30 cm diameter of spherical volume (DSV) of a novel 1 Tesla split bore MRI magnet...
March 26, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29554940/pretreatment-prognostic-factors-of-survival-and-late-toxicities-for-patients-with-nasopharyngeal-carcinoma-treated-by-simultaneous-integrated-boost-intensity-modulated-radiotherapy
#18
Yun-Hsuan Lin, Tai-Lin Huang, Chih-Yen Chien, Hui-Chun Chen, Hsuan-Chih Hsu, Eng-Yen Huang, Chong-Jong Wang, Yu-Jie Huang, Yu-Ming Wang, Chun-Chieh Huang, Shang-Yu Chou, Kuan-Cho Liao, Fu-Min Fang
BACKGROUND: To scrutinize the pretreatment prognosticators on survival and late toxicities in a homogenous cohort of nasopharyngeal carcinoma (NPC) patients treated by simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT). METHODS: A total of 219 non-distant metastatic NPC patients consecutively treated by SIB-IMRT at a single institute were collected. The pretreatment factors including the socio-demographic variables, TNM stages, gross tumor volume (GTV), Epstein-Barr virus (EBV)-DNA, and hematologic inflammatory markers were analyzed...
March 20, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29548559/influence-of-inhomogeneous-radiosensitivity-distributions-and-intrafractional-organ-movement-on-the-tumour-control-probability-of-focused-imrt-in-prostate-cancer
#19
Benedikt Thomann, Ilias Sachpazidis, Khodor Koubar, Constantinos Zamboglou, Panayiotis Mavroidis, Rolf Wiehle, Anca-Ligia Grosu, Dimos Baltas
PURPOSE: To evaluate the influence of radioresistance and intrafractional movement on the tumour control probability (TCP) in IMRT prostate treatments using simultaneous integrated boosts to PSMA-PET/CT-delineated GTVs. MATERIALS AND METHODS: 13 patients had PSMA-PET/CT prior to prostatectomy and histopathological examination. Two GTVs were available: GTV-PET and GTV-histo, which is the true cancer volume. Focused IMRT plans delivering 77 Gy in 35 fractions to the prostate and 95 Gy to PTV-PET were produced...
April 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29522203/optimal-plasma-pretreatment-ebv-dna-cut-off-point-for-nasopharyngeal-cancer-patients-treated-with-intensity-modulated-radiation-therapy
#20
Chawalit Lertbutsayanukul, Danita Kannarunimit, Buntipa Netsawang, Sarin Kitpanit, Chakkapong Chakkabat, Pokrath Hansasuta, Anussara Prayongrat
Objective: Plasma Epstein-Barr virus (EBV) DNA concentration at the time of diagnosis (pre-EBV) can be used to stratify risk for nasopharyngeal cancer (NPC) patients. However, pre-EBV cut-off values vary among studies. Methods: This was a post hoc analysis of 208 NPC patients from a phase II/III study comparing sequential (SEQ) vs. simultaneous integrated boost (SIB) intensity modulated radiation therapy. The objective was to identify the optimal pre-EBV cut-off value to predict overall survival (OS), progression free survival (PFS) and distant metastatic free survival (DMFS) rates...
May 1, 2018: Japanese Journal of Clinical Oncology
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