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https://www.readbyqxmd.com/read/29774372/-optical-coherence-tomography-for-skin-pathologies
#1
REVIEW
J Welzel, S Schuh
Optical coherence tomography (OCT) has become established in routine diagnosis in dermatology only in the last few years. The reason is that the skin is a challenge for OCT as a strong scattering medium, because only a very small proportion of photons is reflected and can be used for imaging. In addition, in most cases a visual assessment or a biopsy is sufficient. Nevertheless, the main field of application in dermatology is the diagnostics of epithelial skin tumors. The OCT is suitable for the early recognition of small, clinically and light microscopically unspecific basal cell carcinomas as well as for the differential diagnosis of other tumors and precancerous lesions...
May 17, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29767718/prediction-of-treatment-outcomes-for-neck-rejuvenation-utilizing-a-unique-classification-system-of-treatment-approach-using-a-1440-nm-side-firing-laser
#2
Gabriella A DiBernardo, Barry E DiBernardo
Background: The appearance of a youthful neck is lost with age causing excessive skin laxity, a loss of subcutaneous fat, prominence of platysmal banding, and jowling. In view of the success obtained with laser treatment for neck rejuvenation, the authors have recently taken an algorithmic approach to developing a 7-category classification system of the aging conditions throughout the anatomic spectrum of three areas: skin, fat, and muscle. This system will correlate with specific treatment options...
May 15, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29766626/co-2-laser-and-photodynamic-therapy-study-of-efficacy-in-periocular-bcc
#3
Santo Raffaele Mercuri, Pina Brianti, Annunziata Dattola, Luigi Bennardo, Martina Silvestri, Giusy Schipani, Steven Paul Nisticò
Basal cell carcinoma (BCC), the most common type of skin cancer in the world, usually arises in sun-exposed areas of the skin. The therapeutic approach to periocular BCC has changed in the last few years. Currently the treatment, considering the delicate localization of the disease, must not only ensure complete recovery from the neoplastic disease, but must also satisfy functional and aesthetic criteria. In this study we tried to evaluate the efficacy of CO2 laser and photodynamic therapy in periocular BCC...
May 15, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29764244/kinetics-and-tissue-repair-process-following-fractional-bipolar-radiofrequency-treatment
#4
G Kokolakis, L von Eichel, M Ulrich, J Lademann, T Zuberbier, M A Hofmann
INTRODUCTION: Fractionated radiofrequency (RF) tissue tightening is an alternative method to fractionated laser treatment of skin wrinkling, laxity and acne scars, with reduced risk of scarring or persistent pigmentation. The aim of this study was to evaluate and quantify the wound healing process after RF treatment. MATERIALS AND METHODS: 12 patients were treated with a 64-pin fractional bipolar RF device with 60 mJ/pin applied energy. Confocal laser scanning microscopy (CLSM) examination was performed on day 1, day 2, day 7 and day 14 after treatment...
May 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29757022/clinical-outcome-of-1064-nm-picosecond-neodymium-doped-yttrium-aluminium-garnet-laser-for-the-treatment-of-hypertrophic-scars
#5
Young-Jun Choi, Jung Yup Kim, Jae-Hui Nam, Ga-Young Lee, Won-Serk Kim
BACKGROUND: Currently no study has evaluated the effect of the novel 1064-nm picosecond neodymium-doped:yttrium aluminium garnet laser (ps-Nd:YAG) for reducing Hypertrophic scarring (HS). OBJECTIVE: The aim of this study was to verify the efficacy and safety of a 1064-nm ps-Nd:YAG in the management of HS. MATERIALS AND METHODS: A retrospective chart review and photographic analysis were conducted on patients treated with a low-fluence 1064-nm ps-Nd:YAG for HS improvement...
May 14, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29744784/acne-scarring-management-systematic-review-and-evaluation-of-the-evidence
#6
REVIEW
Shashank Bhargava, Paulo R Cunha, Jennifer Lee, George Kroumpouzos
BACKGROUND: Modalities for atrophic acne scarring can be classified depending upon the needs they satisfy; that is, resurfacing, lifting/volumization, tightening, or surgical removal/movement of tissue that is required for correction. A plethora of treatment options have resulted from the need to treat various acne scar types, variability of responses noted in various skin types, and increasing popularity of minimally invasive modalities. Still, there is a lack of consensus guidelines on treatment or combination therapies for various clinical scenarios...
May 9, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29744754/less-is-more-similar-efficacy-in-three-sessions-and-seven-sessions-of-pulsed-dye-laser-treatment-in-infantile-port-wine-stain-patients
#7
Jiafang Zhu, Wenxin Yu, Tianyou Wang, Yijie Chen, Dongze Lyu, Lei Chang, Gang Ma, Xiaoxi Lin
Port-wine stains (PWS) affect 0.3 to 0.5% of newborns and pulsed dye laser (PDL) remains the treatment of choice. However, no reliable study regarding the benefits of more frequent has been conducted. We designed the present study to evaluate whether more frequent PDL treatments in infantile patients would achieve further lightening of erythema. We prospectively investigated 20 infants with PWS. Two adjacent sites were both treated for a 12-week duration and randomly allocated to be treated for seven sessions at 2-week intervals or three sessions at 6-week intervals...
May 10, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29740104/setup-errors-and-effectiveness-of-optical-laser-3d-surface-imaging-system-sentinel-in-postoperative-radiotherapy-of-breast-cancer
#8
Xiaobo Wei, Mengjiao Liu, Yun Ding, Qilin Li, Changhai Cheng, Xian Zong, Wenming Yin, Jie Chen, Wendong Gu
Breast-conserving surgery (BCS) plus postoperative radiotherapy has become the standard treatment for early-stage breast cancer. The aim of this study was to compare the setup accuracy of optical surface imaging by the Sentinel system with cone-beam computerized tomography (CBCT) imaging currently used in our clinic for patients received BCS. Two optical surface scans were acquired before and immediately after couch movement correction. The correlation between the setup errors as determined by the initial optical surface scan and CBCT was analyzed...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737551/whole-body-and-local-hyperthermia-enhances-the-photosensitizing-efficacy-of-3-1-hexyloxy-ethyl-3-devinylpyropheophorbide-a-hpph
#9
Avinash Srivatsan, Arindam Sen, Ravindra R Cheruku, Joseph R Missert, Farukh A Durrani, Khurshid Guru, Ravindra K Pandey
BACKGROUND AND OBJECTIVES: In this study, we evaluated the impact of hyperthermia in photosensitizing efficacy of 3-[(1'-hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH or Photochlor) for the treatment of cancer by photodynamic therapy (PDT). STUDY DESIGN/MATERIALS AND METHODS: The outcome of both whole body hyperthermia (WBH) and local hyperthermia (LH) in combination with HPPH-PDT was determined in BALB/c and nude mice bearing Colon26 and U87 tumors, respectively...
May 8, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29731588/resurfacing-of-facial-acne-scars-with-a-new-variable-pulsed-er-yag-laser-in-fitzpatrick-skin-types-iv-and-v
#10
Namitha Chathra, Venkataram Mysore
Introduction: The Er:YAG laser, considered to be less effective than CO2 laser in its traditional form, in its new modulated version has variable pulse technology that is claimed to be superior to the earlier versions of the laser. Aim: The aim of the study was to check efficacy and safety of the new variable square pulse (VSP) Er:YAG laser in the management of acne scar in patients with Fitzpatrick skin types IV and V. Materials and Methods: This retrospective study consisted of 80 patients (Fitzpatrick skin types IV and V) with atrophic and hypertrophic facial acne scars...
January 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29730821/evaluation-of-the-low-level-laser-therapy-application-parameters-for-skin-burn-treatment-in-experimental-model-a-systematic-review
#11
Patricia Brassolatti, Ana Laura Martins de Andrade, Paulo Sérgio Bossini, Albaiza Nicoletti Otterço, Nivaldo Antônio Parizotto
Burn is defined as a traumatic injury of thermal origin, which affects the organic tissue. Low-level laser therapy (LLLT) has gained great prominence as a treatment in this type of injury; however, the application parameters are still controversial in the literature. The aims of this study were to review the literature studies that use LLLT as a treatment in burns conducted in an experimental model, discuss the main parameters used, and highlight the benefits found in order to choose an appropriate therapeutic window to be applied in this type of injury...
May 5, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29726735/therapeutic-strategies-for-pigmented-purpuric-dermatoses-a-systematic-literature-review
#12
Kerasia-Maria Plachouri, Vaia Florou, Sophia Georgiou
Background of the article: Pigmented purpuric dermatoses (PPDs) is a group of diseases with distinguishing clinical characteristics, characterized mainly by purpuric skin lesions. The course of PPDs is chronic and recurrences are common. Although PPDs are considered to be benign, the associated symptoms, such as pruritus, and their cosmetic effect can be extremely distressing to patients. So far no evidence-based treatment has been found to be drastically effective in a large scale of patients. MATERIALS AND METHODS: This paper is a systematic overview of all the reported successful treatments described in the literature...
May 4, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29726114/high-fluence-1064-nm-q-switched-nd-yag-laser-safe-and-effective-treatment-of-caf%C3%A3-au-lait-macules-in-asian-patients
#13
Jin Ok Baek, Il-Joong Park, Kyung Real Lee, Ha Ryeong Ryu, Jeongsoo Kim, Seulki Lee, Yu Ri Kim, Hoon Hur
OBJECTIVES: Café-au-lait macules (CALMs) are benign cutaneous hyperpigmentary disorders. Usually, laser therapies for cosmetic concerns result in more severe side effects in the people of Asian descent than that of Caucasians. Unfortunately, there is no gold standard for the laser treatment of CALMs in skin of people of Asian descent. To investigate the efficacy and safety of a high-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser treatment of CALMs in Asian patients...
May 3, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29725739/the-combination-of-expanded-scalp-flap-and-800-nm-diode-laser-in-the-reconstruction-of-forehead-defect
#14
Yang Li, Weiyang Li, Chaohua Liu, Qing Yang, Ping Xue, Hengxin Liu, Jiangbo Cui, Jianke Ding, Yingjun Su, Xianjie Ma
Skin grafting is often the first choice for closing forehead defects. However, the aesthetics of skin grafting-reconstructed forehead defects are still not accepted by a large number of patients. With the technological advancement of laser hair removal, scalp flaps have been considered as donors for reconstruction of forehead defects. We evaluated 10 cases of forehead defect reconstructions with expanded scalp flaps followed by hair removal by an 800 nm diode laser. All flaps survived uneventfully and underwent 4-6 laser treatments for hair removal...
May 3, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29719624/distribution-of-erlotinib-in-rash-and-normal-skin-in-cancer-patients-receiving-erlotinib-visualized-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging
#15
Meiko Nishimura, Mitsuhiro Hayashi, Yu Mizutani, Kei Takenaka, Yoshinori Imamura, Naoko Chayahara, Masanori Toyoda, Naomi Kiyota, Toru Mukohara, Hiroaki Aikawa, Yasuhiro Fujiwara, Akinobu Hamada, Hironobu Minami
Background: The development of skin rashes is the most common adverse event observed in cancer patients treated with epidermal growth factor receptor-tyrosine kinase inhibitors such as erlotinib. However, the pharmacological evidence has not been fully revealed. Results: Erlotinib distribution in the rashes was more heterogeneous than that in the normal skin, and the rashes contained statistically higher concentrations of erlotinib than adjacent normal skin in the superficial skin layer (229 ± 192 vs...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29717822/soft-and-moldable-mg-doped-liquid-metal-for-conformable-skin-tumor-photothermal-therapy
#16
Xuelin Wang, Wenhao Yao, Rui Guo, Xiaohu Yang, Jianbo Tang, Jie Zhang, Weiping Gao, Victoria Timchenko, Jing Liu
As a class of emerging multifunctional soft materials, gallium-based liquid metal (LM) amalgams, metal/nonmetal particles dispersed in an LM environment, suggest a combination of intriguing properties. In this article, Mg particles in gallium-indium alloy for making new conceptual biomedical materials, which can adapt to any irregular skin surface, are introduced, and superior photothermal effect with a 61.5% photothermal conversion (PTC) increase with respect to that of the LM is realized. The formation of a new intermetallic phase Mg2 Ga5 and adjustable surface roughness, which guarantees a rapid temperature increase when illuminated by laser, are found to be responsible for the photothermal effect enhancement...
May 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29714399/translating-phototherapeutic-indices-from-in-vitro-to-in-vivo-photodynamic-therapy-with-bacteriochlorins
#17
André F S Luz, Barbara Pucelik, Mariette M Pereira, Janusz M Dąbrowski, Luis G Arnaut
OBJECTIVE: To compare hydrophilic and lipophilic bacteriochlorin photosensitizers in the photodynamic therapy of cancer, and relate their properties and in vitro phototoxicities to the efficacy of in vivo PDT treatments. MATERIALS AND METHODS: Photochemical characterization of a hydrophilic bacteriochlorin (F2 BOH) photosensitizer, and its use in PDT was compared with the performance of a closely related but water-insoluble bacteriochlorin (F2 BMet or redaporfin)...
May 1, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29713841/comparative-study-using-fractional-carbon-dioxide-laser-versus-glycolic-acid-peel-in-treatment-of-pseudo-acanthosis-nigricans
#18
N S Zaki, R F Hilal, R M Essam
Pseudo-acanthosis nigricans is a common dermatological disorder that is usually difficult to treat secondary to maceration of the skin from excessive sweating, obesity, or associated with endocrine disorders. Fractional photothermolysis and chemical peeling have been reported to improve the condition. To determine whether fractional CO2 laser resurfacing or glycolic acid peel is more effective and safe option for therapy. Twenty Egyptian patients were included in the study where each patient was subjected to three sessions of both fractional CO2 on the right side of the neck and glycolic acid peel 70% on the left side of the neck...
April 30, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29704068/led-phototherapy-in-full-thickness-burns-induced-by-co-2-laser-in-rats-skin
#19
Milene da Silva Melo, Leandro Procópio Alves, Adriana Barrinha Fernandes, Henrique Cunha Carvalho, Carlos José de Lima, Egberto Munin, Mônica Fernandes Gomes, Miguel Angel Castillo Salgado, Renato Amaro Zângaro
Many studies have been conducted on the treatment of burns because they are important in morbidity and mortality. These studies are mainly focused on improving care and quality of life of patients. The aim of this study was evaluate the LED phototherapy effects in rats skin full-thickness burns induced by CO2 laser. The animals were divided in NT group that did not received any treatment and LED group that received LED irradiation at 685 nm, 220 mW, and 4.5 J/cm2 during 40 s by burned area. Biopsies were obtained after 7, 14, and 21 days of treatment and submitted to histological and immunohistochemical analysis...
April 27, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29700662/is-the-fractional-laser-still-effective-in-assisting-cutaneous-macromolecule-delivery-in-barrier-deficient-skin-psoriasis-and-atopic-dermatitis-as-the-disease-models
#20
Woan-Ruoh Lee, Shing-Chuan Shen, Calvin T Sung, Pei-Ying Liu, Jia-You Fang
PURPOSE: Most of the investigations into laser-assisted skin permeation have used the intact skin as the permeation barrier. Whether the laser is effective in improving cutaneous delivery via barrier-defective skin is still unclear. METHODS: In this study, ablative (Er:YAG) and non-ablative (Er:glass) lasers were examined for the penetration of peptide and siRNA upon topical application on in vitro skin with a healthy or disrupted barrier. RESULTS: An enhanced peptide flux (6...
April 26, 2018: Pharmaceutical Research
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