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https://www.readbyqxmd.com/read/28333339/platelet-rich-plasma-augments-adipose-derived-stem-cell-growth-and-differentiation
#1
Robert P Gersch, Joshua Glahn, Michael G Tecce, Anthony J Wilson, Ivona Percec
Background: Adipose-derived stem cells (ASCs) are a powerful tool for cosmetic surgery and regenerative medicine. The use of autologous platelet rich plasma (PRP), particularly in combination with ASC-based therapy, has significantly expanded in recent years. Unfortunately, the mechanisms and optimal dosing responsible for the beneficial effects of PRP remain poorly understood. Here we investigate the effect of PRP on ASC growth and differentiation. Objectives: To assess the impact of different PRP feeding and cryopreservation protocols on ASC isolation, expansion, and differentiation...
February 22, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28314908/anatomy-and-aesthetics-of-the-labia-minora-the-ideal-vulva
#2
REVIEW
C Clerico, A Larry, A Mojallal, F Boucher
Female genital cosmetic surgery is becoming more and more widespread both in the field of plastic and gynaecological surgery. The increased demand for vulvar surgery is spurred by the belief that the vulva is abnormal in appearance. What is normal in terms of labial anatomy? Labia minora enlargement or hypertrophy remains a clinical diagnosis which is poorly defined as it could be considered a variation of the normal anatomy. Enlarged labia minora can cause functional, aesthetic and psychosocial problems. In reality, given the wide variety of vulvar morphology among people, it is a very subjective issue to define the "normal" vulva...
March 10, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28300445/botanicals-with-dermatologic-properties-derived-from-first-nations-healing
#3
Sophia Colantonio, Jason K Rivers
INTRODUCTION: First Nations people have a long history of working with medicinal plants used to treat skin diseases. The purpose was to assess the dermatologic therapeutic potential of western red cedar, white spruce, birch, balsam poplar, and black spruce. METHODS: Based on expert recommendations, 5 trees were selected that were used in First Nations medicine for cutaneous healing and have potential and/or current application to dermatology today. We searched several databases up to June 12, 2014...
February 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28299610/pharmacovigilance-of-regenerative-medicine-under-the-amended-pharmaceutical-affairs-act-in-japan
#4
Yasuko Inokuma
Two Japanese regulatory agencies, the Ministry of Health, Labour and Welfare and the Pharmaceuticals and Medical Devices Agency announced the implementation of a new review system called 'Conditional Approval,' specifically for the emerging field of regenerative medicine, in an amendment to the Pharmaceutical Affairs Act in 2014. Regenerative medicine was regulated in the category of 'Medical Devices' prior to the amendment and was not covered by the Relief Service, a system that provides financial aid to people who have experienced an adverse drug reaction and developed serious side effects as a result...
March 15, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28294074/probiotics-as-a-tool-to-biosynthesize-metallic-nanoparticles-research-reports-and-patents-survey
#5
Nida Ahktar, Kamla Pathak
BACKGROUND: Probiotics are the live microbes that exert beneficial effects on the health of the host cell and thus creating novel nanoformulations via probiotic bacteria have gained tremendous momentum recently. The probiotic bacteria are being employed in synthesizing or more specifically biosynthesizing several nanoparticles like metallic as well as non-metallic nanoparticles. Biosynthesis of metallic nanoparticles is currently focused of research nowadays due to several applications thereof...
March 13, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28289827/correlation-of-prediction-and-actual-outcome-of-three-dimensional-simulation-in-breast-augmentation-using-a-cloud-based-program
#6
Joshua Vorstenbosch, Avi Islur
BACKGROUND: Breast augmentation is among the most frequently performed cosmetic plastic surgeries. Providing patients with "realistic" 3D simulations of breast augmentation outcomes is becoming increasingly common. Until recently, such programs were costly and required significant equipment, training, and office space. New simple user-friendly cloud-based programs have been developed, but to date there remains a paucity of objective evidence comparing these 3D simulations with the post-operative outcomes...
March 13, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28282873/crystal-structure-of-the-receptor-binding-domain-of-botulinum-neurotoxin-type-ha-also-known-as-type-fa-or-h
#7
Guorui Yao, Kwok-Ho Lam, Kay Perry, Jasmin Weisemann, Andreas Rummel, Rongsheng Jin
Botulinum neurotoxins (BoNTs), which have been exploited as cosmetics and muscle-disorder treatment medicines for decades, are well known for their extreme neurotoxicity to humans. They pose a potential bioterrorism threat because they cause botulism, a flaccid muscular paralysis-associated disease that requires immediate antitoxin treatment and intensive care over a long period of time. In addition to the existing seven established BoNT serotypes (BoNT/A-G), a new mosaic toxin type termed BoNT/HA (aka type FA or H) was reported recently...
March 8, 2017: Toxins
https://www.readbyqxmd.com/read/28273864/screening-of-peruvian-medicinal-plants-for-tyrosinase-inhibitory-properties-identification-of-tyrosinase-inhibitors-in-hypericum-laricifolium-juss
#8
Yanymee Nimesia Guillen Quispe, Seung Hwan Hwang, Zhiqiang Wang, Soon Sung Lim
Tyrosinase inhibitors are of far-ranging importance in cosmetics, medicinal products, and food industries. Peru is a diverse country with a wide variety of plants that may contain excellent anti-tyrosinase inhibitors. In the present study, the tyrosinase inhibitory properties of 50 medicinal plant extracts from Peru were investigated using tyrosinase assay. Among plant extracts, those that showed an inhibition rate >50% were Hypericum laricifolium Juss., Taraxacum officinaleF.H.Wigg., and Muehlenbeckia vulcanicaMeisn...
March 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28273843/effect-of-leaves-of-caesalpinia-decapetala-on-oxidative-stability-of-oil-in-water-emulsions
#9
María Gabriela Gallego, Monika Skowyra, Michael H Gordon, Nurul Aini Mohd Azman, María Pilar Almajano
Caesalpinia decapetala (Roth) Alston (Fabaceae) (CD) is used in folk medicine to prevent colds and treat bronchitis. This plant has antitumor and antioxidant activity. The antioxidant effects of an extract from Caesalpinia decapetala (Fabaceae) were assessed by storage of model food oil-in-water emulsions with analysis of primary and secondary oxidation products. The antioxidant capacity of the plant extract was evaluated by the diphenylpicrylhydrazyl (DPPH), Trolox equivalent antioxidant capacity (TEAC), oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays and by electron paramagnetic resonance (EPR) spectroscopy...
March 4, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28271656/biological-activity-and-toxicity-of-the-chinese-herb-magnolia-officinalis-rehder-e-wilson-houpo-and-its-constituents
#10
Mélanie Poivre, Pierre Duez
Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name "Houpo", has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28267613/effect-of-ultrasound-assisted-extraction-on-the-physicochemical-and-functional-properties-of-collagen-from-soft-shelled-turtle-calipash
#11
Ye Zou, Li Wang, Panpan Cai, Pengpeng Li, Muhan Zhang, Zhilan Sun, Chong Sun, Weimin Xu, Daoying Wang
The aim of the present study was to evaluate the physicochemical and functional properties of acid-soluble collagen by ultrasound assisted extraction (UASC) from calipash of soft-shelled turtle (Pelodiscus sinensis). The results showed the collagen content was increased by 16.3% in UASC over the collagen from the conventional extraction (ASC). Both ASC and UASC contained a moderate amount of imino acid (197 and 216 residues/1000 residues, respectively) and hydrophobic amino acid (353 and 391 residues/1000 residues, respectively) in amino acid composition...
March 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28264507/chemical-composition-antioxidant-antimicrobial-and-cytotoxic-activities-of-essential-oil-from-premna-microphylla-turczaninow
#12
Han-Yu Zhang, Yang Gao, Peng-Xiang Lai
Premna microphylla Turczaninow, an erect shrub, was widely used in Chinese traditional medicine to treat dysentery, appendicitis, and infections. In this study, the essential oil from P. microphylla Turcz. was obtained by hydrodistillation and analyzed by GC (Gas Chromatography) and GC-MS (Gas Chromatography-Mass Spectrometer). Fifty-six compounds were identified in the oil which comprised about 97.2% of the total composition of the oil. Major components of the oil were blumenol C (49.7%), β-cedrene (6.1%), limonene (3...
February 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28261221/allergic-responses-induced-by-the-immunomodulatory-effects-of-nanomaterials-upon-skin-exposure
#13
REVIEW
Yasuo Yoshioka, Etsushi Kuroda, Toshiro Hirai, Yasuo Tsutsumi, Ken J Ishii
Over the past decade, a vast array of nanomaterials has been created through the development of nanotechnology. With the increasing application of these nanomaterials in various fields, such as foods, cosmetics, and medicines, there has been concern about their safety, that is, nanotoxicity. Therefore, there is an urgent need to collect information about the biological effects of nanomaterials so that we can exploit their potential benefits and design safer nanomaterials, while avoiding nanotoxicity as a result of inhalation or skin exposure...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28243734/heterologous-production-of-a-ginsenoside-saponin-compound-k-and-its-precursors-in-transgenic-tobacco-impairs-the-vegetative-and-reproductive-growth
#14
Yu Shin Gwak, Jung Yeon Han, Prakash Babu Adhikari, Chang Ho Ahn, Yong Eui Choi
Production of compound K (a ginsenoside saponin) and its precursors in transgenic tobacco resulted in stunted growth and seed set failure, which may be caused by strong autotoxicity of heterologously produced phytochemicals against the tobacco itself. Panax ginseng roots contain various saponins (ginsenosides), which are major bioactive compounds. A monoglucosylated saponin, compound K (20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol), has high medicinal and cosmetic values but is present in undetectable amounts in naturally grown ginseng roots...
February 27, 2017: Planta
https://www.readbyqxmd.com/read/28229920/in-vitro-wound-healing-and-cytotoxic-activity-of-the-gel-and-whole-leaf-materials-from-selected-aloe-species
#15
Lizelle T Fox, Anisha Mazumder, Anupma Dwivedi, Minja Gerber, Jeanetta du Plessis, Josias H Hamman
ETHNOPHARMACOLOGICAL RELEVANCE: Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ferox and Aloe marlothii are used as traditional medicines for different applications. Although wound healing has been shown for certain aloe gel materials (e.g. A. vera) previously, there are conflicting reports on this medicinal application of aloe leaf gel materials...
February 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28220373/body-dysmorphic-disorder-history-and-curiosities
#16
Katlein França, Maria Grazia Roccia, David Castillo, Mana ALHarbi, Georgi Tchernev, Anastasia Chokoeva, Torello Lotti, Massimo Fioranelli
Body dysmorphic disorder is a chronic psychiatric disorder characterized by excessive preoccupation with an absent or minimal physical deformity. It causes severe distress and impairs normal functioning. In the last centuries, this disorder has been mentioned in the medical literature by important mental health practitioners by different names, such as "dysmorphophobia" or "dermatologic hypochondriasis". However, not until the last century was it included among the obsessive-compulsive disorders, although its classification has changed over time...
February 20, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28219734/position-228-in-paenibacillus-macerans-cyclodextrin-glycosyltransferase-is-critical-for-2-o-d-glucopyranosyl-l-ascorbic-acid-synthesis
#17
Sheng Chen, Yanjun Xiong, Lingqia Su, Lei Wang, Jing Wu
The markedly stable l-ascorbic acid (L-AA) derivative 2-O-d-glucopyranosyl-l-ascorbic acid (AA-2G) has been widely used in the fields of food, medicine, cosmetics, and husbandry. Cyclodextrin glycosyltransferase (CGTase) is considered suitable for the large-scale production of AA-2G. In this work, Paenibacillus macerans CGTase was used to produce AA-2G and the production was 13.5g/l. An amino-acid sequence alignment of α-, β-, and α⁄β-CGTase indicated that the Phe at position 228 of P. macerans CGTase was different from the amino acids at this position in other CGTases (Met, Val, or Ile)...
February 17, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28216888/effect-of-absolute-from-hibiscus-syriacus-l-flower-on-wound-healing-in-keratinocytes
#18
Seok Won Yoon, Kang Pa Lee, Do-Yoon Kim, Dae Il Hwang, Kyung-Jong Won, Dae Won Lee, Hwan Myung Lee
BACKGROUND: Proliferation and migration of keratinocytes are essential for the repair of cutaneous wounds. Hibiscus syriacus L. has been used in Asian medicine; however, research on keratinocytes is inadequate. OBJECTIVE: To establish the dermatological properties of absolute from Hibiscus syriacus L. flower (HSF) and to provide fundamental research for alternative medicine. MATERIALS AND METHODS: We identified the composition of HSF absolute using gas chromatography-mass spectrometry analysis...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28216554/harnessing-nanoparticles-for-immunomodulation-and-vaccines
#19
REVIEW
Ariane C Gomes, Mona Mohsen, Martin F Bachmann
The first successful use of nanoparticles (NPs) for vaccination was reported almost 40 years ago with a virus-like particle-based vaccine against Hepatitis B. Since then, the term NP has been expanded to accommodate a large number of novel nano-sized particles engineered from a range of materials. The great interest in NPs is likely not only a result of the two successful vaccines against hepatitis B and Human Papilloma Virus (HPV) that use this technology, but also due to the versatility of those small-sized particles, as indicated by the wide range of applications reported so far, ranging from medicinal and cosmetics to purely technical applications...
February 14, 2017: Vaccines
https://www.readbyqxmd.com/read/28214585/preparation-and-biocompatibility-of-a-chitin-nanofiber-gelatin-composite-film
#20
Yoko Ogawa, Kazuo Azuma, Hironori Izawa, Minoru Morimoto, Kosuke Ochi, Tomohiro Osaki, Norihiko Ito, Yoshiharu Okamoto, Hiroyuki Saimoto, Shinsuke Ifuku
The development of chitin-based materials with favorable mechanical properties and biocompatibility is an important research goal owing to the wide-ranging practical applications. In this study, a composite film was prepared using chitin nanofibers and gelatin. The CNF/gelatin composite film was highly viscous and had a fine nanofiber structure. The transmittances indicated high transparency, regardless of nanofiber content. The water content of the CNF/gelatin composite film increased linearly as the gelatin content increased...
February 16, 2017: International Journal of Biological Macromolecules
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