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Cyanotic heart disease

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https://www.readbyqxmd.com/read/29146625/cyanotic-congenital-heart-disease-following-fertility-treatments-in-the-united-states-from-2011-to-2014
#1
Alireza A Shamshirsaz, Zhoobin H Bateni, Haleh Sangi-Haghpeykar, Sara E Arian, Hadi Erfani, Amir A Shamshirsaz, Alfred Abuhamad, Karin A Fox, Susan M Ramin, Amirhossein Moaddab, Shiraz A Maskatia, Bahram Salmanian, Keila N Lopez, Pardis Hosseinzadeh, Amy K Schutt, Ahmed A Nassr, Jimmy Espinoza, Gary A Dildy, Michael A Belfort, Steven L Clark
OBJECTIVE: To examine the risk for cyanotic congenital heart diseases (CCHDs) among live births in the USA, resulting from various forms of infertility treatments. METHODS: This study is a cross-sectional analysis of live births in the USA from 2011 to 2014. Infertility treatments are categorised into two of the following groups on birth certificates: assisted reproductive technology (ART) fertility treatment (surgical egg removal; eg, in vitro fertilisation and gamete intrafallopian transfer) and non-ART fertility treatment (eg, medical treatment and intrauterine insemination)...
November 16, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29132469/-clinical-characteristics-and-prognostic-analysis-of-children-with-congenital-heart-disease-complicated-by-postoperative-acute-kidney-injury
#2
Lian Duan, Guo-Huang Hu, Meng Jiang, Cheng-Liang Zhang
OBJECTIVE: To analyze the perioperative clinical data of children with congenital heart disease complicated by acute kidney injury (AKI) after cardiopulmonary bypass (CPB) surgery, and to explore potential factors influencing the prognosis. METHODS: A retrospective analysis was performed among 118 children with congenital heart disease who developed AKI within 48 hours after CPB surgery. RESULTS: In the 118 patients, 18 died after 48 hours of surgery...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29121718/non-invasive-assessment-of-liver-changes-in-eisenmenger-patients
#3
Siegrun Mebus, Nicole Nagdyman, Johanna Kügel, Reinhart Zachoval, Siegmund Lorenz Braun, Guido Haverkämper, Bernd Opgen-Rhein, Felix Berger, Sophia Horster, Jörg Schoetzau, Claudia Pujol Salvador, Ulrike Bauer, John Hess, Peter Ewert, Harald Kaemmerer
BACKGROUND: Eisenmenger syndrome as a severe form of cyanotic congenital heart disease results in a complex multisystemic disorder. Due to increased systemic venous pressure and the inability to ensure systemic perfusion and metabolic requirements, the liver may develop congestion, fibrosis or cirrhosis. This study aimed to assess hepatic abnormalities in Eisenmenger patients non-invasively. METHODS AND RESULTS: 10 adults with Eisenmenger syndrome (six female; median age 44...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29120021/swiss-adult-congenital-heart-disease-registry-sacher-rationale-design-and-first-results
#4
Daniel Tobler, Markus Schwerzmann, Judith Bouchardy, Reto Engel, Dominik Stambach, Christine Attenhofer Jost, Kerstin Wustmann, Fabienne Schwitz, Tobias Rutz, Harald Gabriel, Hans Peter Kuen, Christoph Auf der Maur, Angela Oxenius, Theresa Seeliger, Bruno Santos Lopes, Francesca Bonassin, Matthias Greutmann, On Behalf Of Sacher
BACKGROUND: In 2013, a prospective registry for adults with congenital heart disease (CHD) was established in Switzerland, providing detailed data on disease characteristics and outcomes: Swiss Adult Congenital HEart disease Registry (SACHER). Its aim is to improve the knowledge base of outcomes in adults with CHD. The registry design and baseline patient characteristics are reported. METHODS: All patients with structural congenital heart defects or hereditary aortopathies, followed-up at dedicated adult CHD clinics, are asked to participate in SACHER...
November 9, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29103857/phenotype-management-and-predictors-of-outcome-in-a-large-cohort-of-adult-congenital-heart-disease-patients-with-heart-failure
#5
Alexander Van De Bruaene, Edward J Hickey, Adrienne H Kovacs, Andrew M Crean, Rachel M Wald, Candice K Silversides, Andrew N Redington, Heather J Ross, Ana Carolina Alba, Filio Billia, Krishnakumar Nair, Lee Benson, Eric Horlick, Mark Osten, Jack Colman, Jane Heggie, Erwin N Oechslin, S Lucy Roche
OBJECTIVE: Although heart failure (HF) is the leading cause of premature death in adult congenital heart disease (ACHD), little population-specific data exist. This study reports early experience from a dedicated, sub-specialty adult congenital heart disease-heart failure (ACHD-HF) clinic, aiming to identify risk factors for adverse outcome. METHODS: Between 2012 and 2015, 126 patients (57% male) attended the ACHD-HF clinic. Baseline and follow-up data were analysed and compared across 4 anatomical/physiological subgroups: cyanotic ACHD, Fontan circulation (1V), biventricular circulation with a subaortic right ventricle (2V-RV) and biventricular circulation with a subaortic left ventricle (2V-LV)...
October 31, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29103604/incidence-predictors-and-mortality-of-infective-endocarditis-in-adults-with-congenital-heart-disease-without-prosthetic-valves
#6
Darren Mylotte, Dinela Rushani, Judith Therrien, Liming Guo, Aihua Liu, Kenneth Guo, Giuseppe Martucci, Andrew S Mackie, Jay S Kaufman, Ariane Marelli
Congenital heart disease (CHD) increases the risk of infective endocarditis (IE), though the lesion-specific risk and mortality are poorly defined. Using the population-based Quebec CHD database, we sought to describe the predictors of IE and to evaluate if IE was associated with mortality among adult CHD (ACHD) patients without prior valve replacement surgery. We extracted data on ACHD patients with IE and assessed the lesion-specific incidence of IE, risk factors for IE acquisition, and all-cause 1-year mortality...
October 14, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29078258/effects-of-mir-23b-on-hypoxia-induced-cardiomyocytes-apoptosis
#7
Weilai He, Hong Che, Chaolong Jin, Shenglin Ge
OBJECTIVES: The aim of this study was to investigate the role of miR-23b in hypoxic cardiomyocytes and the potential mechanism. METHODS: Myocardial samples of patients with cyanotic or acyanotic congenital heart disease (CHD) were collected to evaluate miR-23b expression. Agomir or antagomir of miR-23b was transfected into H9C2 cells. MTT, LDH assay and TUNEL staining were used to determine the cell proliferation and apoptosis under hypoxic conditions. Besides, the expression levels of cleaved-caspase-3, cleaved-PARP, Bad, Bcl-2 and Bax in hypoxic H9C2 cells were determined by western blot and qRT-PCR, respectively...
October 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29065963/neurodevelopmental-outcomes-at-two-years-of-age-for-premature-infants-diagnosed-with-neonatal-obstructive-sleep-apnea
#8
Anuja Bandyopadhyay, Heidi Harmon, James E Slaven, Ameet S Daftary
STUDY OBJECTIVES: Neurocognitive deficits have been shown in school-aged children with sleep apnea. The effect of obstructive sleep apnea (OSA) on the neurodevelopmental outcome of preterm infants is unknown. METHODS: A retrospective chart review was performed for all preterm infants (< 37 weeks) who had neonatal polysomnography (PSG) and completed neurodevelopmental assessment with the Bayley Scales of Infant and Toddler Development, 3rd Edition, between 2006 to 2015 at Riley Hospital...
October 18, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29057376/p2y12-receptor-function-and-response-to-cangrelor-in-neonates-with-cyanotic-congenital-heart-disease
#9
Elisabeth A Kaza, Matthew C Egalka, Hairu Zhou, Jianchun Chen, Denise Evans, Jayne Prats, Ruizhi Li, Scott L Diamond, Julie A Vincent, Emile A Bacha, Thomas G Diacovo
Shunt thrombosis remains a major cause of morbidity and mortality, especially during the initial palliation for single-ventricle physiology. The authors present evidence that the P2Y12 inhibitor cangrelor may fill a therapeutic void in thromboprophylaxis. They base this theory on results showing that platelets from neonatal patients with cyanotic congenital heart disease have a robust response to adenosine diphosphate and are amenable to P2Y12 inhibition with cangrelor. Unique to this study was their ability to establish drug efficacy in an avatar mouse model that permits the in vivo evaluation of human platelet-mediated thrombus formation illustrating that this P2Y12 inhibitor yields the intended biological response...
August 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/29041891/-functional-state-of-vascular-endothelium-in-patients-with-pulmonary-arterial-hypertension-associated-with-congenital-heart-diseases
#10
Y E Emelyanchik, G N Vol'f, A O Vesemiller, B A Salmina
In this article, we present results of the study of blebbing activity of membranes of peripheral blood lymphocytes, concentrations of soluble platelet/endothelial cell adhesion molecule 1, and vascular endothelial growth factor (VEGF) in patients with pulmonary arterial hypertension associated with congenital heart diseases. The research has shown that hypoxia and hemodynamic factors are the initiators of blebbing of membrane of peripheral blood lymphocytes. The activity of blebbing increases in parallel with the severity of the disease...
August 2017: Kardiologiia
https://www.readbyqxmd.com/read/28973997/the-heart-club-how-cyanotic-heart-disease-was-reframed
#11
Tom Treasure
In April 1948, the thoracic surgeon, Russell Brock, convened a meeting at Guy's Hospital [...].
September 30, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28971263/is-it-time-for-a-multi-specialty-approach-to-cardio-renal-dysfunction-in-children-with-cyanotic-congenital-heart-disease
#12
Tanya Holt, Guido Filler
No abstract text is available yet for this article.
October 2, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28971258/prevalence-and-associated-factors-of-renal-dysfunction-and-proteinuria-in-cyanotic-congenital-heart-disease
#13
Nattaphorn Hongsawong, Prapimdaw Khamdee, Suchaya Silvilairat, Wattana Chartapisak
BACKGROUND: Cyanotic nephropathy (CN), seen in 30-50% of patients with congenital cyanotic heart disease (CCHD), affects both tubular and glomerular function, resulting in proteinuria and azotemia. Microalbuminuria is an early marker for glomerular damage and an independent predictor of progressive renal disease. METHODS: A cross-sectional study was conducted. A total of 116 patients aged 1 month to 15 years with CCHD at Chiang Mai University Hospital between 2015 and 2016 were assessed and 94 patients were enrolled...
October 2, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28963608/acyanotic-and-cyanotic-congenital-heart-diseases
#14
REVIEW
Manojkumar Rohit, Smit Shrivastava
There has been tremendous progress in treatment of heart disease in children. Device therapy is increasingly being used in acyanotic congenital heart disease, while surgical results have improved significantly to give smile to many cyanotic heart disease children and their parents. This article makes an attempt to increase awareness of general pediatricians about common congenital heart diseases.
September 30, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28948316/long-standing-cyanosis-in-congenital-heart-disease-does-not-cause-diffuse-myocardial-fibrosis
#15
Ahmed Kharabish, Christian Meierhofer, Martin Hadamitzky, Jonathan Nadjiri, Stefan Martinoff, Peter Ewert, Heiko Stern
The assumption of the presence of diffuse myocardial fibrosis in long-standing cyanotic congenital heart disease (CHD) inspired us to noninvasively determine the myocardial extracellular volume (ECV) using contrast CMR. T1 maps were measured pre and 10 min after the injection of 0.15 mmol/kg of gadolinium in 25 subjects. Seven patients with long-standing cyanotic CHD and no previous cardiac surgery (aged 16-53 years and oxygen saturations of 69-90%), nine normal subjects (aged 14-49 years), and nine patients with previously cyanotic CHD, who had been corrected by open heart surgery (aged 2 months-58 years, mean 9 years)...
September 25, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28928620/consideration-of-pyloric-stenosis-as-a-cause-of-feeding-dysfunction-in-children-with-cyanotic-heart-disease
#16
Nayan T Srivastava, John J Parent, Marcus S Schamberger
Feeding difficulty has been reported at a higher incidence in infants with cyanotic heart disease and single ventricle physiology necessitating specialized feeding strategies. However, structural causes of feed intolerance in this subset of patients should not be ignored. This case series highlights three recent cases of pyloric stenosis in infants with left-sided obstructive lesions at our institution. In all three cases, the initial presumed diagnosis was feeding intolerance related to heart disease, and there was significant clinical improvement following identification and correction of pyloric stenosis...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28928619/percutaneous-management-of-complex-acquired-aortic-coarctation-in-an-adult-with-tetralogy-of-fallot-and-pulmonary-atresia
#17
Michael D Seckeler, Emily Lawson, Brent J Barber, Scott E Klewer
We present the case of a female adult with complex cyanotic congenital heart disease who had long-standing thoracic aortic obstruction due to scarring from earlier surgical procedures. She was symptomatic but felt to be too high risk for surgical intervention. With careful planning, she was able to undergo successful stenting of her aorta with subsequent clinical improvement. This case highlights some of the complexities of caring for adults with congenital heart disease and the importance of a thorough understanding of their anatomy and physiology and prior interventions before undertaking interventions...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28923474/beyond-the-inhaled-nitric-oxide-in-persistent-pulmonary-hypertension-of-the-newborn
#18
REVIEW
Mei-Yin Lai, Shih-Ming Chu, Satyan Lakshminrusimha, Hung-Chih Lin
Persistent pulmonary hypertension (PPHN) is a consequence of failed pulmonary vascular transition at birth and leads to pulmonary hypertension with shunting of deoxygenated blood across the ductus arteriosus (DA) and foramen ovale (FO) resulting in severe hypoxemia, and it may eventually lead to life-threatening circulatory failure. PPHN is a serious event affecting both term and preterm infants in the neonatal intensive care unit. It is often associated with diseases such as congenital diaphragmatic hernia, meconium aspiration, sepsis, congenital pneumonia, birth asphyxia and respiratory distress syndrome...
August 10, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28920017/esophageal-atresia-with-tracheo-esophageal-fistula-presenting-beyond-7-days
#19
Nilesh Nagdeve, Mohini Sukhdeve, Tushar Thakre, Suresh Morey
AIM: To describe our experience of neonates with esophageal atresia with tracheo-esophageal fistula (EA with TEF) who presented after a week. DESIGN: Retrospective study of the patients of EA with TEF who presented after a week. STUDY SETTING: Department of Pediatric Surgery, Government Medical College Nagpur. Study Duration: Eight years. MATERIALS AND METHODS: Demographic information, hematological, biochemical and radiological data were obtained from the patients' medical records...
July 2017: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/28903840/burr-hole-aspiration-of-brain-abscess-in-children-with-cyanotic-heart-disease
#20
Muhammad Ashraf, Shakeel Ahmed, Shafiq Ahmad, Mukhtar Hussain
OBJECTIVE: To determine the efficacy of burr hole aspiration of brain abscess in children with cyanotic heart disease in terms of number of aspirations and residual abscess. STUDY DESIGN: Experimental study. PLACE AND DURATION OF STUDY: Department of Pediatric Neurosurgery at The Children's Hospital and The Institute of Child Health, Multan, from July 2010 to June 2014. METHODOLOGY: Pediatric patients of cyanotic heart disease with brain abscess were admitted...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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