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https://www.readbyqxmd.com/read/28456085/single-sensor-for-multiple-analytes-in-different-optical-channel-applying-for-multi-ion-response-modulation
#1
Chunshuang Liang, Shimei Jiang
A Schiff-base, (2,4-di-tert-butyl-6-((2-hydroxyphenyl-imino)-methyl)phenol) (L), has been improved to function as a simultaneous multi-ion probe in different optical channel. The probe changes from colorless to orangish upon being deprotonated by F(-), while the presence of Al(3+) significantly enhances the fluorescence of the probe due to the inhibition of CN isomerization, cation-induced inhibition of excited-state intramolecular proton transfer (ESIPT), and chelation enhanced fluorescence (CHEF). Dual-channel "off-on" switching behavior resulted from the sequential input of F(-) and Al(3+), reflecting the balance of independent reactions of Al(3+) and F(-) with L and with one another...
April 18, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28455958/csfv-induced-mitochondrial-fission-and-mitophagy-to-inhibit-apoptosis
#2
Hongchao Gou, Mingqiu Zhao, Hailuan Xu, Jin Yuan, Wencheng He, Mengjiao Zhu, Hongxing Ding, Lin Yi, Jinding Chen
Classical swine fever virus (CSFV), which causes typical clinical characteristics in piglets, including hemorrhagic syndrome and immunosuppression, is linked to hepatitis C and dengue virus. Oxidative stress and a reduced mitochondrial transmembrane potential are disturbed in CSFV-infected cells. The balance of mitochondrial dynamics is essential for cellular homeostasis. In this study, we offer the first evidence that CSFV induces mitochondrial fission and mitophagy to inhibit host cell apoptosis for persistent infection...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455878/impact-of-plerixafor-mozobil-on-hospital-efficiency-a-single-center-experience
#3
Nabih Azar, Maya Ouzegdouh, Sylvain Choquet, Véronique Leblond
Plerixafor (Mozobil) in combination with granulocyte colony-stimulating factor (G-CSF) has shown to increase mobilization of peripheral blood stem cells (PBSC) as compared to G-CSF alone in patients undergoing autologous stem cell transplantation (ASCT). However, up to 25% of patients treated with G-CSF alone still fail mobilization. Adding plerixafor to poor mobilizers allows to rescue these patients from mobilization failure and to reduce the number of apheresis sessions. The goal of this retrospective study was to capture the impact of plerixafor on treatment outcome and on apheresis department efficiency...
April 28, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28455796/effect-of-brood-pheromone-on-survival-and-nutrient-intake-of-african-honey-bees-apis-mellifera-scutellata-under-controlled-conditions
#4
Fabien J Démares, Abdullahi A Yusuf, Susan W Nicolson, Christian W W Pirk
The influence of pheromones on insect physiology and behavior has been thoroughly reported for numerous aspects, such as attraction, gland development, aggregation, mate and kin recognition. Brood pheromone (BP) is released by honey bee larvae to indicate their protein requirements to the colony. Although BP is known to modulate pollen and protein consumption, which in turn can affect physiological and morphological parameters, such as hypopharyngeal gland (HPG) development and ovarian activation, few studies have focused on the effect of BP on nutritional balance...
April 28, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28455713/macrophages-and-their-contribution-to-the-development-of-atherosclerosis
#5
Yuri V Bobryshev, Nikita G Nikiforov, Natalia V Elizova, Alexander N Orekhov
Atherosclerosis can be regarded as chronic inflammatory disease driven by lipid accumulation in the arterial wall. Macrophages play a key role in the development of local inflammatory response and atherosclerotic lesion growth. Atherosclerotic plaque is a complex microenvironment, in which different subsets of macrophages coexist executing distinct, although in some cases overlapping functions. According to the classical simplified nomenclature, lesion macrophages can belong to pro-inflammatory or anti-inflammatory or alternatively activated types...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28455704/development-and-functional-differentiation-of-tissue-resident-versus-monocyte-derived-macrophages-in-inflammatory-reactions
#6
Paola Italiani, Diana Boraschi
Mononuclear phagocytes are key cells in tissue integrity and defense. Tissue-resident macrophages are abundantly present in all tissues of the body and have a complex role in ensuring tissue functions and homeostatic balance. Circulating blood monocytes can enter tissue both in steady-state conditions, for helping in replenishing the tissue-resident macrophage pool and, in particular, for acting as potent effector cells during inflammatory events such as infections, traumas, and diseases. The heterogeneity of monocytes and macrophages depends on their ontogeny, their tissue location, and their functional programming, with both monocytes and macrophages able to exert distinct or similar functions depending on the tissue-specific and stimulus-specific microenvironment...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28455623/classification-of-normal-sagittal-spine-alignment-refounding-the-roussouly-classification
#7
Féthi Laouissat, Amer Sebaaly, Martin Gehrchen, Pierre Roussouly
PURPOSE: Although the Roussouly classification of common variants in spinal sagittal alignment is well accepted, no studies have implemented it in an asymptomatic adult population. In addition, no study investigated the radiographic features of asymptomatic patients with an anteverted pelvis. The aim of this prospective radiographic study of 296 asymptomatic adults without spinal pathology was to investigate how the Roussouly classification could include the anteverted pelvis concept...
April 28, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28455617/progressive-response-of-large-intestinal-bacterial-community-and-fermentation-to-the-stepwise-decrease-of-dietary-crude-protein-level-in-growing-pigs
#8
Yu Peng, Kaifan Yu, Chunlong Mu, Suqin Hang, Lianqiang Che, Weiyun Zhu
The study aimed to determine the effects of reduction of dietary crude protein (CP) level with balanced essential amino acids (EAA) on intestinal bacteria and their metabolites of growing pigs. Forty pigs (initial BW 13.50 ± 0.50 kg, 45 ± 2 days of age) were randomly assigned to four dietary treatments containing CP levels at 20.00% (normal crude protein, NP); 17.16% (medium crude protein, MP); 15.30% (low crude protein, LP); and 13.90% (extremely low crude protein, ELP), respectively. Crystalline AAs were added to meet the EAA requirement of pigs...
April 29, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28455582/glutathione-s-transferases-deletions-may-act-as-prognosis-and-therapeutic-markers-in-breast-cancer
#9
Clodoaldo Zago Campos, Roberta Losi Guembarovski, Carlos Eduardo Coral de Oliveira, Bruna Karina Banin Hirata, Glauco Akelinghton Freire Vitiello, Flávia Luísa Dias, Carlos Hiroji Hiroki, Maria Angelica Ehara Watanabe, Tânia Longo Mazzuco
Breast cancer (BC) is the main worldwide neoplasia in women. The metabolic balance between xenobiotic absorption and elimination rates plays an important role in preventing DNA damage and, consequently, tumor development. The glutathione S-transferases (GSTs), such as GSTM1 and GSTT1, and the NAD(P)H quinone oxidoreductase are important enzymes involved in phase II detoxification reactions. Deletions in GSTM1 and GSTT1, and single-nucleotide polymorphism (SNP) in NQO1 (rs1800655) have been investigated in cancer context, revealing conflicting results...
April 28, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28455510/effects-of-fertilization-on-crop-production-and-nutrient-supplying-capacity-under-rice-oilseed-rape-rotation-system
#10
Muhammad Yousaf, Jifu Li, Jianwei Lu, Tao Ren, Rihuan Cong, Shah Fahad, Xiaokun Li
Incredible accomplishments have been achieved in agricultural production in China, but many demanding challenges for ensuring food security and environmental sustainability remain. Field experiments were conducted from 2011-2013 at three different sites, including Honghu, Shayang, and Jingzhou in China, to determine the effects of fertilization on enhancing crop productivity and indigenous nutrient-supplying capacity (INuS) in a rice (Oryza sativa L.)-rapeseed (Brassica napus L.) rotation. Four mineral fertilizer treatments (NPK, NP, NK and PK) were applied in a randomized complete block design with three replicates...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28455499/families-of-stable-solitons-and-excitations-in-the-pt-symmetric-nonlinear-schr%C3%A3-dinger-equations-with-position-dependent-effective-masses
#11
Yong Chen, Zhenya Yan, Dumitru Mihalache, Boris A Malomed
Since the parity-time-([Formula: see text]-) symmetric quantum mechanics was put forward, fundamental properties of some linear and nonlinear models with [Formula: see text]-symmetric potentials have been investigated. However, previous studies of [Formula: see text]-symmetric waves were limited to constant diffraction coefficients in the ambient medium. Here we address effects of variable diffraction coefficient on the beam dynamics in nonlinear media with generalized [Formula: see text]-symmetric Scarf-II potentials...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28455494/novel-1-5%C3%A2-gpa-strength-with-50-ductility-by-transformation-induced-plasticity-of-non-recrystallized-austenite-in-duplex-steels
#12
Seok Su Sohn, Hyejin Song, Min Chul Jo, Taejin Song, Hyoung Seop Kim, Sunghak Lee
Needs for steel designs of ultra-high strength and excellent ductility have been an important issue in worldwide automotive industries to achieve energy conservation, improvement of safety, and crashworthiness qualities. Because of various drawbacks in existing 1.5-GPa-grade steels, new development of formable cold-rolled ultra-high-strength steels is essentially needed. Here we show a plausible method to achieve ultra-high strengths of 1.0~1.5 GPa together with excellent ductility above 50% by actively utilizing non-recrystallization region and TRansformation-Induced Plasticity (TRIP) mechanism in a cold-rolled and annealed Fe-Mn-Al-C-based steel...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28455477/long-term-outcomes-of-cemented-versus-cementless-humeral-components-in-arthroplasty-of-the-shoulder-a-propensity-score-matched-analysis
#13
J-D Werthel, G Lonjon, S Jo, R Cofield, J W Sperling, B T Elhassan
AIMS: In the initial development of total shoulder arthroplasty (TSA), the humeral component was usually fixed with cement. Cementless components were subsequently introduced. The aim of this study was to compare the long-term outcome of cemented and cementless humeral components in arthroplasty of the shoulder. PATIENTS AND METHODS: All patients who underwent primary arthroplasty of the shoulder at our institution between 1970 and 2012 were included in the study...
May 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28455453/short-term-heat-stress-alters-redox-balance-in-porcine-skeletal-muscle
#14
Olga Volodina, Shanthi Ganesan, Sarah C Pearce, Nicholas K Gabler, Lance H Baumgard, Robert P Rhoads, Joshua T Selsby
Heat stress contributes to higher morbidity and mortality in humans and animals and is an agricultural economic challenge because it reduces livestock productivity. Redox balance and associated mitochondrial responses appear to play a central role in heat stress-induced skeletal muscle pathology. We have previously reported increased oxidative stress and mitochondrial content in oxidative muscle following 12 h of heat stress. The purposes of this investigation were to characterize heat stress-induced oxidative stress and changes in mitochondrial content and biogenic signaling in oxidative skeletal muscle...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28455378/ehmt2-g9a-controls-placental-vascular-maturation-by-activating-the-notch-pathway
#15
Lijun Chi, Abdalla Ahmed, Anna R Roy, Sandra Vuong, Lindsay S Cahill, Laura Caporiccio, John G Sled, Isabella Caniggia, Michael D Wilson, Paul Delgado-Olguin
Defective fetoplacental vascular maturation causes intrauterine growth restriction (IUGR). A transcriptional switch initiates placental maturation where blood vessels elongate. However, cellular mechanisms and regulatory pathways involved are unknown. We show that the histone methyltransferase Ehmt2, also known as G9a, activates the Notch pathway to promote placental vascular maturation. Placental vasculature from embryos with G9a-deficient endothelial progenitor cells failed to expand due to decreased endothelial cell proliferation and increased trophoblast proliferation...
April 28, 2017: Development
https://www.readbyqxmd.com/read/28455244/got1-mediated-anaplerotic-glutamine-metabolism-regulates-chronic-acidosis-stress-in-pancreatic-cancer-cells
#16
Jaime Abrego, Venugopal Gunda, Enza Vernucci, Surendra K Shukla, Ryan J King, Aneesha Dasgupta, Gennifer Goode, Divya Murthy, Fang Yu, Pankaj K Singh
The increased rate of glycolysis and reduced oxidative metabolism are the principal biochemical phenotypes observed in pancreatic ductal adenocarcinoma (PDAC) that lead to the development of an acidic tumor microenvironment. The pH of most epithelial cell-derived tumors is reported to be lower than that of plasma. However, little is known regarding the physiology and metabolism of cancer cells enduring chronic acidosis. Here, we cultured PDAC cells in chronic acidosis (pH 6.9∼7.0) and observed that cells cultured in low pH had reduced clonogenic capacity...
April 25, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28455231/multiple-functional-attributes-of-glucose-monitoring-neurons-in-the-medial-orbitofrontal-ventrolateral-prefrontal-cortex
#17
REVIEW
István Szabó, Edina Hormay, Bettina Csetényi, Bernadett Nagy, László Lénárd, Zoltán Karádi
Multiple functional attributes of glucose-monitoring neurons in the medial orbitofrontal (ventrolateral prefrontal) cortex. NEUROSCI BIOBEHAV REV 73(1) XXX-XXX, 2017.- Special chemosensory cells, the glucose-monitoring (GM) neurons, reportedly involved in the central feeding control, exist in the medial orbitofrontal (ventrolateral prefrontal) cortex (mVLPFC). Electrophysiological, metabolic and behavioral studies reveal complex functional attributes of these cells and raise their homeostatic significance. Single neuron recordings, by means of the multibarreled microelectrophoretic technique, elucidate differential sensitivities of limbic forebrain neurons in the rat and the rhesus monkey to glucose and other chemicals, whereas gustatory stimulations demonstrate their distinct taste responsiveness...
April 25, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28455137/influence-of-static-magnetic-field-exposure-into-fatty-acid-composition-in-salmonella-hadar
#18
Ramla Ben Mouhoub, Alya El May, Imed Cheraief, Ahmed Landoulsi
We have been interested, in this work, to investigate the effect of the exposure to static magnetic field at 200 mT (SMF) on the fatty acid (FA) composition of Salmonella enterica subsp Enterica serovar Hadar isolate 287: effects on the proportion of saturated and unsaturated fatty acids (SFAs, UFAs), cyclopropane fatty acids (CFAs) and hydroxy fatty acids after exposure to the static magnetic field at 200 mT (SMF). Analysis with Gas Chromatography-Mass Spectrometry (GC-MS) of total lipid showed that the proportion of the most fatty acids was clearly affected...
April 25, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28455119/changes-of-cecal-microflora-in-chickens-following-eimeria-tenella-challenge-and-regulating-effect-of-coated-sodium-butyrate
#19
Zuoyong Zhou, Kui Nie, Qingzhou Huang, Kai Li, Sun Yingying, Rongqiong Zhou, Zhiying Wang, Shijun Hu
Eimeria tenella, one of the most important parasitic protozoa in the genus Eimeria, is responsible for chicken caecal coccidiosis resulting in huge economic losses to poultry industry. The present study investigated the changes in caecal microflora of E. tenella-infected chickens and the regulating effect of coated sodium butyrate, a potential alternative to antibiotics. Using high-throughput sequencing of 16S rRNA V3-V4 region of bacteria we found significant changes in caecal microflora of E. tenella-infected chickens indicated by an increase of Firmicutes (mainly Ruminococcaceae, Lachnospiraceae and vadin BB60) and Proteobacteria (mainly Enterobacteriaceae) and a decrease of Bacteroidetes (predominantly Bacteroidaceae)...
April 25, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28455085/randomized-controlled-trial-of-intravenous-acetaminophen-for-post-cesarean-delivery-pain-control
#20
Brie Altenau, Catrina C Crisp, C Ganga Devaiah, Donna S Lambers
BACKGROUND: Cesarean delivery is a common surgery in the United States with 1.3 million performed during 2009.(1) Obstetricians must balance the growing concern with opioid abuse, dependence and side effects with optimal post-operative pain control. IV acetaminophen may represent an additional method to decrease the reliance on opioid medications and improve post-operative pain following cesarean section. OBJECTIVE: To determine if administration of IV acetaminophen following routine scheduled cesarean delivery would decrease the need for narcotic medications to control post-operative pain...
April 25, 2017: American Journal of Obstetrics and Gynecology
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