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https://www.readbyqxmd.com/read/29224147/comprehensive-whole-dna-methylome-analysis-by-integrating-medip-seq-and-mre-seq
#1
Xiaoyun Xing, Bo Zhang, Daofeng Li, Ting Wang
Understanding the role of DNA methylation often requires accurate assessment and comparison of these modifications in a genome-wide fashion. Sequencing-based DNA methylation profiling provides an unprecedented opportunity to map and compare complete DNA CpG methylomes. These include whole genome bisulfite sequencing (WGBS), Reduced-Representation Bisulfite-Sequencing (RRBS), and enrichment-based methods such as MeDIP-seq, MBD-seq, and MRE-seq. An investigator needs a method that is flexible with the quantity of input DNA, provides the appropriate balance among genomic CpG coverage, resolution, quantitative accuracy, and cost, and comes with robust bioinformatics software for analyzing the data...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29224105/nuclear-and-membrane-actions-of-estrogen-receptor-alpha-contribution-to-the-regulation-of-energy-and-glucose-homeostasis
#2
Maeva Guillaume, Alexandra Montagner, Coralie Fontaine, Françoise Lenfant, Jean-François Arnal, Pierre Gourdy
Estrogen receptor alpha (ERα) has been demonstrated to play a key role in reproduction but also to exert numerous functions in nonreproductive tissues. Accordingly, ERα is now recognized as a key regulator of energy homeostasis and glucose metabolism and mediates the protective effects of estrogens against obesity and type 2 diabetes. This chapter attempts to summarize our current understanding of the mechanisms of ERα activation and their involvement in the modulation of energy balance and glucose metabolism...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224103/sex-differences-and-role-of-estradiol-in-hypoglycemia-associated-counter-regulation
#3
Karen P Briski, Hussain N Alhamami, Ayed Alshamrani, Santosh K Mandal, Manita Shakya, Mostafa H H Ibrahim
Vital nerve cell functions, including maintenance of transmembrane voltage and information transfer, occur at high energy expense. Inadequate provision of the obligate metabolic fuel glucose exposes neurons to risk of dysfunction or injury. Clinical hypoglycemia rarely occurs in nondiabetic individuals but is an unfortunate regular occurrence in patients with type 1 or advanced insulin-treated type 2 diabetes mellitus. Requisite strict glycemic control, involving treatment with insulin, sulfonylureas, or glinides, can cause frequent episodes of iatrogenic hypoglycemia due to defective counter-regulation, including reduced glycemic thresholds and diminished magnitude of motor responses...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224101/estradiol-regulation-of-brown-adipose-tissue-thermogenesis
#4
Ismael González-García, Manuel Tena-Sempere, Miguel López
Physiologically, estrogens carry out a myriad of functions, the most essential being the regulation of the reproductive axis. Currently, it is also dogmatic that estrogens play an important role modulating energy balance and metabolism. In this sense, it is well known that low estrogens levels, occurring due to ovarian insufficiency, in conditions such as menopause or ovariectomy (OVX), are associated with increased food intake and decreased energy expenditure, leading to weight gain and obesity at long term...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224087/epidemiology-of-gender-differences-in-diabetes-and-obesity
#5
Franck Mauvais-Jarvis
Some aspects of glucose homeostasis and energy balance are regulated differently in males and females. This review discusses the most fundamental gender differences in diabetes and obesity, including the prevalence of impaired fasting glucose and impaired glucose tolerance, the prevalence and incidence of type 2 and type 1 diabetes, as well as the prevalence of metabolic syndrome and obesity. These gender-specific differences in glucose homeostasis and energy balance represent a source of factors that should be studied to develop gender-based therapeutic avenues for diabetes...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224030/advances-in-fractional-technology-for-skin-rejuvenation-skin-tightening-drug-delivery-and-treating-scars-and-skin-defects
#6
Deirdre Connolly, Laura Schilling, Nazanin Saedi
The development of fractional photothermolysis has revolutionized the treatment of skin scarring, rejuvenation, and tightening. By creating targeted microthermal zones and leaving surrounding tissue intact, this concept has provided the field with efficacious results, with less downtime and a better safety profile. This has started to change the paradigm of what is considered first-line treatment for scarring and rejuvenation. While originally applied to nonablative lasers, fractionation has now been employed in ablative, quality-switched, picosecond, and novel hybrid fractional lasers...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29223904/spatiotemporal-variations-of-hydrogeochemistry-and-its-controlling-factors-in-the-gandaki-river-basin-central-himalaya-nepal
#7
Ramesh Raj Pant, Fan Zhang, Faizan Ur Rehman, Guanxing Wang, Ming Ye, Chen Zeng, Handuo Tang
The characterization and assessment of water quality in the head water region of Himalaya is necessary, given the immense importance of this region in sustaining livelihoods of people and maintaining ecological balance. A total of 165 water samples were collected from 55 sites during pre-monsoon, monsoon and post-monsoon seasons in 2016 from the Gandaki River Basin of the Central Himalaya, Nepal. The pH, EC values and TDS concentrations were measured in-situ and the concentrations of major ions (Ca2+, Mg2+, K+, Na+, Cl-, SO42-, NO3-) and Si were analyzed in laboratory...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223847/funding-breakthrough-therapies-a-systematic-review-and-recommendation
#8
REVIEW
E Hanna, M Toumi, C Dussart, B Borissov, O Dabbous, K Badora, P Auquier
BACKGROUND: Advanced therapy medicinal products (ATMPs) are innovative therapies likely associated with high prices. Payers need guidance to create a balance between ensuring patient access to breakthrough therapies and maintaining the financial sustainability of the healthcare system. OBJECTIVE: The aims of this study were to identify, define, classify and compare the approaches to funding high-cost medicines proposed in the literature, to analyze their appropriateness for ATMP funding and to suggest an optimal funding model for ATMPs...
December 2, 2017: Health Policy
https://www.readbyqxmd.com/read/29223816/cortex-and-hippocampus-dna-epigenetic-response-to-a-long-term-arsenic-exposure-via-drinking-water
#9
Xiaoyan Du, Meiping Tian, Xiaoxue Wang, Jie Zhang, Qingyu Huang, Liangpo Liu, Heqing Shen
The neurotoxicity of arsenic is a serious health problem, especially for children. DNA epigenetic change may be an important pathogenic mechanism, but the molecular pathway remains obscure. In this study, the weaned male Sprague-Dawly (SD) rats were treated with arsenic trioxide via drinking water for 6 months, simulating real developmental exposure situation of children. Arsenic exposure impaired the cognitive abilities, and altered the expression of neuronal activity-regulated genes. Total arsenic concentrations of cortex and hippocampus tissues were significantly increased in a dose-dependent manner...
December 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29223807/design-synthesis-and-biological-evaluation-of-deuterated-phenylpropionic-acid-derivatives-as-potent-and-long-acting-free-fatty-acid-receptor-1-agonists
#10
Zheng Li, Chunxia Liu, Xue Xu, Wei Shi, Huilan Li, Yuxuan Dai, Xingguang Cai, Wenlong Huang, Hai Qian
The free fatty acid receptor 1 (FFA1) is a potential target due to its function in enhancement of glucose-stimulated insulin secretion. Takeda's compound 1 has robustly in vitro activity for FFA1, but it has been suffered from poor pharmacokinetic (PK) profiles because the phenylpropanoic acid is vulnerable to β-oxidation. To identify orally available agonists, we tried to interdict the metabolically labile group by incorporating two deuterium atoms at the α-position of phenylpropionic acid. Interestingly, the differences of physicochemical properties between hydrogen and deuterium are quite small, but there are many differences in the structure-activity relationship between phenylpropionic acid series and present deuterated series...
December 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29223668/transumbilical-extracorporeal-laparoscopic-assisted-appendectomy
#11
Lindsey Perea, William H Peranteau, Pablo Laje
AIM OF THE STUDY: The perfect balance between safety, cosmesis, and cost effectiveness in a world with ever growing healthcare costs has yet to be found for nonperforated appendicitis. The aim is to present our data regarding safety and cost effectiveness of the transumbilical extracorporeal laparoscopic-assisted appendectomy technique. METHODS: A retrospective review was performed for all laparoscopic appendectomies for acute appendicitis from October 2014 to October 2016...
November 13, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29223575/a-comparison-between-inhalational-desflurane-and-total-intravenous-anaesthesia-propofol-and-dexmedetomidine-in-improving-postoperative-recovery-for-morbidly-obese-patients-undergoing-laparoscopic-sleeve-gastrectomy-a-double-blinded-randomised-controlled-trial
#12
Abd-Elazeem Elbakry, Wesam-Eldin Sultan, Ezzeldin Ibrahim
STUDY OBJECTIVE: Laparoscopic sleeve gastrectomy is commonly performed under total intravenous anaesthesia (TIVA) or balanced anaesthesia using an intravenous and inhalation agent. It is still unclear which anaesthesia regimen is better for this group of patients. The present study has been conducted to compare the use of the inhalation anaesthesia technique using desflurane with the TIVA technique, using propofol and dexmedetomidine. DESIGN: Prospective, randomised, double-blinded study...
December 7, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29223514/need-for-integrative-thinking-to-fight-against-emerging-infectious-diseases-proceedings-of-the-5th-seminar-on-emerging-infectious-diseases-march-22-2016-%C3%A2-current-trends-and-proposals
#13
C Burdet, J-F Guégan, X Duval, M Le Tyrant, H Bergeron, J-C Manuguerra, J Raude, C Leport, P Zylberman
We present here the proceedings of the 5th seminar on emerging infectious diseases, held in Paris on March 22nd, 2016, with seven priority proposals that can be outlined as follows: encourage research on the prediction, screening and early detection of new risks of infection; develop research and surveillance concerning transmission of pathogens between animals and humans, with their reinforcement in particular in intertropical areas ("hot-spots") via public support; pursue aid development and support in these areas of prevention and training for local health personnel, and foster risk awareness in the population; ensure adapted patient care in order to promote adherence to treatment and to epidemic propagation reduction measures; develop greater awareness and better education among politicians and healthcare providers, in order to ensure more adapted response to new types of crises; modify the logic of governance, drawing from all available modes of communication and incorporating new information-sharing tools; develop economic research on the fight against emerging infectious diseases, taking into account specific driving factors in order to create a balance between preventive and curative approaches...
December 6, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/29223482/reactor-performance-and-energy-analysis-of-solid-state-anaerobic-co-digestion-of-dairy-manure-with-corn-stover-and-tomato-residues
#14
Yangyang Li, Fuqing Xu, Yu Li, Jiaxin Lu, Shuyan Li, Ajay Shah, Xuehua Zhang, Hongyu Zhang, Xiaoyan Gong, Guoxue Li
Anaerobic co-digestion is commonly believed to be benefical for biogas production. However, additional of co-substrates may require additional energy inputs and thus affect the overall energy efficiency of the system. In this study, reactor performance and energy analysis of solid state anaerobic digestion (SS-AD) of tomato residues with dairy manure and corn stover were investigated. Different fractions of tomato residues (0, 20, 40, 60, 80 and 100%, based on volatile solid weight (VS)) were co-digested with dairy manure and corn stover at 15% total solids...
December 6, 2017: Waste Management
https://www.readbyqxmd.com/read/29223435/atrial-fibrillation-decision-support-tool-population-perspective
#15
Mark H Eckman, Alexandru Costea, Mehran Attari, Jitender Munjal, Ruth E Wise, Carol Knochelmann, Matthew L Flaherty, Pete Baker, Robert Ireton, Brett M Harnett, Anthony C Leonard, Dylan Steen, Adam Rose, John Kues
BACKGROUND: Appropriate thromboprophylaxis for patients with atrial fibrillation or atrial flutter (AF) remains a national challenge. The recent availability of direct oral anticoagulants (DOACs) with comparable efficacy and improved safety compared with warfarin alters the balance between risk factors for stroke and benefit of anticoagulation. Our objective was to examine the impact of DOACs as an alternative to warfarin on the net benefit of oral anticoagulant therapy (OAT) in a real-world population of AF patients...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29223361/evidence-suggests-sphingosine-1-phosphate-might-be-actively-generated-degraded-and-transported-to-extracellular-spaces-with-increased-s1p2-and-s1p3-expression-in-colon%C3%A2-cancer
#16
Baasanjav Uranbileg, Takeshi Nishikawa, Hitoshi Ikeda, Makoto Kurano, Masaya Sato, Daisuke Saigusa, Junken Aoki, Toshiaki Watanabe, Yutaka Yatomi
BACKGROUND: A pivotal role of sphingosine 1-phosphate (S1P) in cancer has been suggested based on the ceramide-S1P rheostat theory that the intracellular balance between prosurvival S1P and proapoptotic ceramide determines cell fate. Upregulation of S1P-generating sphingosine kinases (SKs) and downregulation of S1P-degrading S1P lyase (SPL) might increase intracellular S1P levels to exert a prosurvival effect in cancer in general, such as colon cancer. However, we recently observed a distinct S1P metabolism in hepatocellular carcinoma tissues that increased SPL mRNA levels with reduced S1P levels...
November 21, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29223349/the-effect-of-cerebellar-transcranial-direct-current-stimulation-on-a-throwing-task-depends-on-individual-level-of-task-performance
#17
Nobuaki Mizuguchi, Takashi Katayama, Kazuyuki Kanosue
The effect of cerebellar transcranial direct current stimulation (tDCS) on motor performance remains controversial. Some studies suggest that the effect of tDCS depends upon task-difficulty and individual level of task performance. Here, we investigated whether the effect of cerebellar tDCS on the motor performance depends upon the individual's level of performance. Twenty-four naïve participants practiced dart throwing while receiving 2mA-cerebellar tDCS for 20min under three stimulus conditions (anodal-, cathodal-, and sham-tDCS) on separate days with a double-blind, counter-balanced cross-over design...
December 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/29223201/investigating-balance-in-teacher-job-attitudes-using-polynomial-regression-and-response-surface-methodology
#18
Christopher R Warren
Organizational theorists have long advocated the importance of attending to multiple stakeholders. However, limited empirical research has been devoted to the ways in which to identify balance, or imbalance, between stakeholder groups possibly due to methodological issues with modeling such complex nomological nets. The current study utilized the multiple stakeholder climate framework to test hypothesized relationships between perceptions of support and affectively-based criteria using polynomial regression and response surface methodology to test discreet regression lines representing predictions...
January 2018: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/29223103/bilateral-early-activity-in-the-hip-flexors-associated-with-falls-in-stroke-survivors-preliminary-evidence-from-laboratory-induced-falls
#19
Dmitrijs Celinskis, Mark D Grabiner, Claire F Honeycutt
OBJECTIVE: Falls are the most common and expensive medical complication following stroke. Hypermetric reflexes have been suggested to impact post-stroke balance but no study has evaluated reflex amplitudes under real conditions of falls in this population. Our objective was to quantify the early reflexive responses during falls induced in the laboratory. METHODS: Sixteen stroke survivors were exposed to posteriorly directed treadmill perturbations that required a forward step to maintain a balance...
November 21, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29223082/deep-rooted-apple-trees-decrease-groundwater-recharge-in-the-highland-region-of-the-loess-plateau-china
#20
Zhiqiang Zhang, Min Li, Bingcheng Si, Hao Feng
Unlike recharge in shallow rooted ecosystems, estimating the groundwater recharge beneath deep rooted plants that absorb water from deep soil remains difficult. The purpose of this research is to develop an approach to estimate the groundwater recharge beneath deep-rooted vegetation by combining water mass balance and chloride mass balance (CMB) and to quantify how the conversion of shallow-rooted cropland to deep-rooted apple orchards changes groundwater recharge. The proposed groundwater recharge rate under deep-rooted vegetation in this study is the difference between the groundwater recharge rate in a cropland (obtained using CMB) and the mean annual soil water storage deficit beneath an adjacent deep-rooted vegetation...
December 6, 2017: Science of the Total Environment
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