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https://www.readbyqxmd.com/read/29458174/networks-that-link-cytoskeletal-regulators-and-diaphragm-proteins-underpin-filtration-function-in-drosophila-nephrocytes
#1
Simi Muraleedharan, Aksah Sam, Helen Skaer, Maneesha S Inamdar
Insect nephrocytes provide a valuable model for kidney disease, as they are structurally and functionally homologous to mammalian kidney podocytes. They possess an exceptional macromolecular assembly, the nephrocyte diaphragm (ND), which serves as a filtration barrier and helps maintain tissue homeostasis by filtering out wastes and toxic products. However, the elements that maintain nephrocyte architecture and the ND are not understood. We show that Drosophila nephrocytes have a unique cytoplasmic cluster of F-actin, which is maintained by the microtubule cytoskeleton and Rho-GTPases...
February 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29458121/the-paradox-of-marrow-adipose-tissue-in-anorexia-nervosa
#2
Pouneh K Fazeli, Anne Klibanski
Anorexia nervosa (AN) is a psychiatric disorder characterized by inappropriate nutrient intake resulting in low body weight. Multiple hormonal adaptations facilitate decreased energy expenditure in this state of caloric deprivation including non-thyroidal illness syndrome, growth hormone resistance, and hypogonadotropic hypogonadism. Although these hormonal adaptations confer a survival advantage during periods of negative energy balance, they contribute to the long-term medical complications associated with AN, the most common of which is significant bone loss and an increased risk of fracture...
February 16, 2018: Bone
https://www.readbyqxmd.com/read/29458015/sulfenamide-and-sulfonamide-derivatives-of-metformin-can-exert-anti-coagulant-and-pro-fibrinolytic-properties
#3
Magdalena Markowicz-Piasecka, Kristiina M Huttunen, Łukasz Mateusiak, Elżbieta Mikiciuk-Olasik, Joanna Sikora
Type 2 diabetes mellitus (T2DM) is characterised not only by hyperglycaemia and insulin resistance but also an impaired balance between the processes of coagulation and fibrinolysis. The aim of this study was to examine the effects of metformin, a widely-used oral anti-diabetic drug, phenformin and eight sulfenamide and sulfonamide derivatives of metformin on several haemostasis parameters. Thrombin Time (TT) tests were performed according to the available commercial method. The activity of factor X was conducted based on deficient plasma factor X...
February 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29457997/detection-of-acute-and-long-term-effects-of-concussion-dual-task-gait-balance-control-vs-computerized-neurocognitive-test
#4
David R Howell, Louis R Osternig, Li-Shan Chou
OBJECTIVE: Our aim was to examine the acute (within 72 hours of injury) and long-term (2 months post-injury) independent associations between objective dual-task gait balance and neurocognitive measurements among adolescents and young adults with a concussion and matched controls. DESIGN: Longitudinal case-control SETTING: Motion analysis laboratory PARTICIPANTS: Participants who sustained a concussion underwent a dual-task gait analysis and computerized neurocognitive testing within 72 hours of injury and again 2 months later...
February 16, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29457996/the-tyg-index-cutoff-point-and-its-association-with-body-adiposity-and-lifestyle-in-children
#5
Sarah A Vieira Ribeiro, Poliana C A Fonseca, Cristiana S Andreoli, Andréia Q Ribeiro, Helen H M Hermsdorff, Patrícia F Pereira, Silvia E Priore, Sylvia C C Franceschini
OBJECTIVE: To investigate the factors associated with insulin resistance in children aged 4-7 years, and to identify the cutoff point of the triglyceride-glucose index for the prediction of IR in this population. METHODS: A cross-sectional study was conducted with 403 children from a retrospective cohort. Insulin resistance was also evaluated in a sub-sample using the HOMA index. Four indicators of body adiposity were assessed: body mass index, waist-to-height ratio, and the percentages of total and central body fat...
February 16, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29457973/pyrazole-tetrazole-hybrid-bearing-the-trinitromethyl-fluorodinitromethyl-or-difluoroamino-dinitromethyl-groups-high-performance-energetic-materials
#6
Aleksei B Sheremetev, Igor L Dalinger, Nikita V Muravyev, Kyrill Yu Suponitsky, Aleksandr V Kormanov
High nitrogen compounds have acquired great scientific interest and technological importance because of their unique energy content, and they find diverse applications in many fields of science and technology. Understanding of structure-property relationship trends as well as how to modify them is of paramount importance for their further improvement. Herein, we have used installation of oxygen-rich modules, C(NO2)3, C(NO2)2F or C(NO2)2NF2, to a endothermic framework, that is combination of nitropyrazole unit and tetrazole ring, as a way to design novel energetic compounds...
February 19, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29457949/nhs-compensations-payouts-balancing-the-issues
#7
John Tingle
John Tingle, Associate Professor (Teaching and Scholarship), Nottingham Trent University, calls for a more balanced view to be taken of issues in the context of the debate on the high costs of clinical negligence claims.
February 22, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29457920/a-critical-appraisal-of-the-reporting-quality-of-published-randomized-controlled-trials-in-the-fall-injuries
#8
Mohammad Asghari Jafarabadi, Homayoun Sadeghi-Bazrgani, Iman Dianat
To evaluate the quality of reporting in published randomized controlled trials (RTCs) in the field of fall injuries. The 188 RTCs published between 2001 and 2011, indexed in EMBASE and Medline databases were extracted through searching by appropriate keywords and EMTree classification terms. The evaluation trustworthiness was assured through parallel evaluations of two experts in epidemiology and biostatistics. About 40%-75% of papers had problems in reporting random allocation method, allocation concealment, random allocation implementation, blinding and similarity among groups, intention to treat and balancing benefits and harms...
February 19, 2018: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/29457831/low-t3-syndrome-as-a-predictor-of-poor-prognosis-in-chronic-lymphocytic-leukemia
#9
Rui Gao, Rui-Ze Chen, Yi Xia, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Jia-Zhu Wu, Lei Fan, Jian-Yong Li, Tao Yang, Wei Xu
Low triiodothyronine (T3) state is associated with poor prognosis in critical acute and prolonged illness. However, the information on thyroid dysfunction and cancer is limited. The aim of our study was to evaluate the prognostic value of low T3 syndrome in chronic lymphocytic leukemia (CLL). Two hundred and fifty-eight patients with detailed thyroid hormone profile at CLL diagnosis were enrolled. Low T3 syndrome was defined by low free T3 (FT3) level accompanied by normal-to-low free tetraiodothyronine (FT4) and thyroid-stimulating hormone (TSH) levels...
February 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29457691/apportioning-bacterial-carbon-source-utilization-in-soil-using-14-c-isotope-analysis-of-fish-targeted-bacterial-populations-sorted-by-fluorescence-activated-cell-sorting-facs-14-c-fish-facs
#10
Christos Gougoulias, Andrew Meade, Liz J Shaw
An unresolved need in microbial ecology is methodology to enable quantitative analysis of in situ microbial substrate carbon use at the population level. Here, we evaluated if a novel combination of radiocarbon- labelled substrate tracing, Fluorescence in situ Hybridisation (FISH) and Fluorescence-Activated Cell Sorting (FACS) to sort the FISH-targeted population for quantification of incorporated radioactivity (14 C-FISH-FACS) can address this need. Our test scenario used FISH probe PSE1284 targeting Pseudomonas spp...
February 19, 2018: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/29457650/effects-of-applying-oil-extracted-microalgae-on-the-fermentation-quality-feed-nutritive-value-and-aerobic-stability-of-ensiled-sweet-sorghum
#11
Lei Chen, Xianjun Yuan, Junfeng Li, Zhihao Dong, Tao Shao
BACKGROUND: A laboratory-silo study was conducted to evaluate the fermentation quality, feed-nutritive value and aerobic stability of sweet sorghum silage with or without oil-extracted microalgae supplementation. Sweet sorghum was mixed with four microalgae levels (0%, 1%, 2% and 3% on a dry matter basis; Control, M1, M2 and M3, respectively) and ensiled for 45 d. Further, the four experimental silages were subjected to an aerobic stability test lasting 7 d. RESULTS: All the silages except M3 silage had good fermentative characteristics with low pH and ammonia nitrogen concentrations, and high lactic acid concentrations and favorable microbial parameters...
February 19, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29457640/application-of-adaptive-laboratory-evolution-to-overcome-a-flux-limitation-in-an-escherichia-coli-production-strain
#12
Kento Tokuyama, Yoshihiro Toya, Takaaki Horinouchi, Chikara Furusawa, Fumio Matsuda, Hiroshi Shimizu
Gene deletion strategies using flux balance analysis (FBA) have improved the growth-coupled production of various compounds. However, the productivities were often below the expectation because the cells failed to adapt to these genetic perturbations. Here, we demonstrate the productivity of the succinate of the designed gene deletion strain was improved by adaptive laboratory evolution (ALE). Although FBA predicted deletions of adhE-pykAF-gldA-pflB lead to produce succinate from glycerol with a yield of 0...
February 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29457560/prophylactic-intra-aortic-balloon-counterpulsation-before-surgical-myocardial-revascularization-in-patients-with-acute-myocardial-infarction
#13
Philippe Grieshaber, Tobias Schneider, Lukas Oster, Coskun Orhan, Peter Roth, Bernd Niemann, Andreas Böning
INTRODUCTION: Prophylactic intra-aortic balloon counterpulsation (pIABC) is recommended for high-risk patients undergoing coronary artery bypass grafting (CABG) surgery. Criteria for high-risk patients benefiting from pIABC are unclear. This study aimed to specifically describe the effect of pIABC on outcomes of patients with acute myocardial infarction (AMI) undergoing CABG. METHODS: In 178 of 484 AMI patients (non-ST-segment elevation myocardial infarction [NSTEMI] or ST-segment elevation myocardial infarction [STEMI] ≤5 days before surgery) without cardiogenic shock who underwent CABG between 2008 and 2013, pIABC was initiated preoperatively...
February 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29457347/comparison-of-the-oral-absorption-distribution-excretion-and-bioavailability-of-zinc-sulfate-zinc-gluconate-and-zinc-enriched-yeast-in-rats
#14
Shuang-Qing Zhang, Xue-Feng Yu, Hai-Bo Zhang, Ning Peng, Zhi-Xian Chen, Qian Cheng, Xiao-Li Zhang, Sui-Han Cheng, Yan Zhang
SCOPE: The oral absorption, distribution, excretion and bioavailability of zinc sulfate (ZnS), zinc gluconate (ZnG) and zinc-enriched yeast (ZnY) in rats were fully and systemically compared for the first time. METHODS AND RESULTS: After zinc compounds were orally administered to rats at a single dose of 4 mg Zn/kg, blood, tissues, urine and feces at different time points were collected for the quantification of zinc concentration. Blood was also harvested for the zinc assay in the multiple-dose administration...
February 19, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29457342/soft-tissue-balancing-in-total-knee-arthroplasty-using-sensor-guided-assessment-is-there-a-learning-curve
#15
Monther A Gharaibeh, Darren B Chen, Samuel J MacDessi
BACKGROUND: Sensor-guided assessment for soft tissue balance in total knee arthroplasty (TKA) has been reported to improve patient satisfaction and self-reported outcome scores. As more surgeons adopt this technology in TKA, we performed this study to identify if there is a learning curve with its use. METHODS: Analysis of a total of 90 consecutive cases was performed in this study. Initial and final intercompartmental pressure differences were recorded before and after knee ligament balancing...
February 18, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29457268/the-lymphoid-cell-network-in-the-skin
#16
REVIEW
Shweta Tikoo, Rohit Jain, Angela R M Kurz, Wolfgang Weninger
Cutaneous immunity represents a crucial component of the mammalian immune response. The presence of a large array of commensal microorganisms along with a myriad of environmental stresses necessitates constant immuno-surveillance of the tissue. To achieve a perfect balance between immune-tolerance and immune-activation, the skin harbours strategically localised immune cell populations that modulate these responses. To maintain homeostasis, innate and adaptive immune cells assimilate microenvironmental cues and coordinate cellular and molecular functions in a spatiotemporal manner...
February 19, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29457185/effect-of-large-deformation-and-surface-stiffening-on-the-transmission-of-a-line-load-on-a-neo-hookean-half-space
#17
Haibin Wu, Zezhou Liu, Anand Jagota, Chung-Yuen Hui
A line force acting on a soft elastic solid, say due to the surface tension of a liquid drop, can cause significant deformation and the formation of a kink close to the point of force application. Analysis based on linearized elasticity theory shows that sufficiently close to its point of application, the force is borne entirely by the surface stress, not by the elasticity of the substrate; this local balance of three forces is called Neumann's triangle. However, it is not difficult to imagine realistic properties for which this force balance cannot be satisfied...
February 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29457164/effect-on-absorption-and-electron-transfer-by-using-cd-ii-or-cu-ii-complexes-with-phenanthroline-as-auxiliary-electron-acceptors-a-in-d-a-%C3%AF-a-motif-sensitizers-for-dye-sensitized-solar-cells
#18
Chang Xia, Chunxiao Zhu, Xiaomei Zhao, Xu Chen, Tianqi Chen, Ting Wan, Zehua Xu, Gaofeng Wen, Yong Pei, Chaofan Zhong
To broaden the absorption spectrum, improve intramolecular electronic push-pull balance capability, enhance electron transfer and promote the photovoltaic performances of dye sensitizers, four new polymeric metal complex dyes (PBDTT-PhenCd, PBDTT-PhenCu, PPV-PhenCd and PPV-PhenCu) with donor-acceptor-π-bridge-acceptor (D-A-π-A) structure were designed and synthesized. These dyes, for the first time, used the complexes of Cd(ii) or Cu(ii) with phenanthroline as auxiliary electron acceptors (A) instead of organic electron withdrawing groups and adopted thienylbenzo [1,2-b:4,5-b'] dithiophene (BDTT) or hydroquinone (PV) derivatives as electron donors (D) and 8-quinolinol derivatives as π bridge and acceptors (A)...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29457117/goal-directed-therapy-reduces-fluid-balance-while-maintaining-hemodynamic-stability-in-intraoperative-management-of-pancreaticoduodenectomy-a-retrospective-comparative-study
#19
Satoshi Ishihara, Takeshi Yokoyama, Katsuyuki Katayama
Background: Goal-directed therapy (GDT) is beneficial for surgical patients, especially for those undergoing high-risk surgery. However, little has been reported on the hemodynamic effects of GDT in extensive surgery. We conducted a study to determine the impact of GDT on intraoperative management of extensive surgery. Findings: We retrospectively collected data from 90 patients who underwent pancreaticoduodenectomy: 44 who received intraoperative GDT (GDT group) and 46 who received conventional hemodynamic management (control group)...
2018: JA Clin Rep
https://www.readbyqxmd.com/read/29456856/design-principles-of-perovskites-for-solar-driven-thermochemical-splitting-of-co-2
#20
Miriam Ezbiri, Michael Takacs, Boris Stolz, Jeffrey Lungthok, Aldo Steinfeld, Ronald Michalsky
Perovskites are attractive redox materials for thermo/electrochemical fuel synthesis. To design perovskites with balanced redox energetics for thermochemically splitting CO2 , the activity of lattice oxygen vacancies and stability against crystal phase changes and detrimental carbonate formation are predicted for a representative range of perovskites by electronic structure computations. Systematic trends in these materials properties when doping with selected metal cations are described in the free energy range defined for isothermal and temperature-swing redox cycles...
August 7, 2017: Journal of Materials Chemistry. A, Materials for Energy and Sustainability
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