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https://www.readbyqxmd.com/read/28647908/cmv-immune-evasion-and-manipulation-of-the-immune-system-with-aging
#1
REVIEW
Sarah E Jackson, Anke Redeker, Ramon Arens, Debbie van Baarle, Sara P H van den Berg, Chris A Benedict, Luka Čičin-Šain, Ann B Hill, Mark R Wills
Human cytomegalovirus (HCMV) encodes numerous proteins and microRNAs that function to evade the immune response and allow the virus to replicate and disseminate in the face of a competent innate and acquired immune system. The establishment of a latent infection by CMV, which if completely quiescent at the level of viral gene expression would represent an ultimate in immune evasion strategies, is not sufficient for lifelong persistence and dissemination of the virus. CMV needs to reactivate and replicate in a lytic cycle of infection in order to disseminate further, which occurs in the face of a fully primed secondary immune response...
June 24, 2017: GeroScience
https://www.readbyqxmd.com/read/28647858/counter-intuitive-plasma-vitamin-d-and-zinc-status-in-hiv-1-infected-adults-with-persistent-low-level-viraemia-after-treatment-initiation-a-pilot-case-control-study
#2
H Melliez, A Duhamel, O Robineau, L Bocket, I Kim, E Sauser, F Loiseleur, N Viget, A Pasquet, E Senneville, D Seguy
Determinants of persistent low-level viraemia [PLLV, a viral load (VL) of between 50 and 500 copies/mL] have not been elucidated. In a case-control study, we evaluated the influence of micronutrients on PLLV in a population of 454 HIV-1 adults having initiated antiretroviral therapy (ART) between January 2007 and December 2011. Plasma levels of retinol (vitamin A), 25-OH vitamin D2 + D3, vitamin E and zinc were measured at ART initiation in cases (PLLV after 6 months of ART) and in controls (VL <50 copies/mL after 6 months)...
June 24, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28647839/do-bumble-bee-bombus-impatiens-queens-signal-their-reproductive-and-mating-status-to-their-workers
#3
Etya Amsalem, Mario Padilla, Paul M Schreiber, Naomi S Altman, Abraham Hefetz, Christina M Grozinger
Reproduction in social insect societies reflects a delicate balance between cooperation and conflict over offspring production, and worker reproduction is widespread even in species showing strong reproductive skew in favor of the queen. To navigate these conflicts, workers are predicted to develop the means to estimate the queen's fecundity - potentially through behavioral and/or chemical cues - and to adjust their reproduction to maximize their fitness. Here, we introduced bumble bee, Bombus impatiens, workers to queens of different mating and reproductive status and examined worker reproduction and expression levels of two genes which were previously shown to be sensitive to the presence of the queen, vitellogenin and Krüppel-homolog 1...
June 24, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28647814/the-effects-of-variable-practice-on-locomotor-adaptation-to-a-novel-asymmetric-gait
#4
Jacob W Hinkel-Lipsker, Michael E Hahn
Very little is known about the effects of specific practice on motor learning of predictive balance control during novel bipedal gait. This information could provide an insight into how the direction and magnitude of predictive errors during acquisition of a novel gait task influence transfer of balance control, as well as yield a practice protocol for the restoration of balance for those with locomotor impairments. This study examined the effect of a variable practice paradigm on transfer of a novel asymmetric gait pattern in able-bodied individuals...
June 24, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28647808/characterization-of-arabidopsis-thaliana-regrowth-patterns-suggests-a-trade-off-between-undamaged-fitness-and-damage-tolerance
#5
Daniel R Scholes, Erika N Rasnick, Ken N Paige
Herbivory is a fundamental type of plant-animal interaction that presents substantial selection pressure on plants to replace lost tissues and to prevent subsequent losses in fitness. Apical herbivory, which entails removal or damage to the apical meristem, causes a change in plant architecture by disrupting the balance of hormones produced in part by the apical meristem. Therefore, for an annual semelparous plant, the ability to preserve reproductive success following damage (i.e., to tolerate damage) is largely dependent on the plant's pre-damage investment into fitness and its regrowth pattern following damage...
June 24, 2017: Oecologia
https://www.readbyqxmd.com/read/28647690/acute-kidney-injury-after-primary-angioplasty-is-contrast-induced-nephropathy-the-culprit
#6
Oren Caspi, Manhal Habib, Yuval Cohen, Arthur Kerner, Ariel Roguin, Eitan Abergel, Monther Boulos, Michael R Kapeliovich, Rafael Beyar, Eugenia Nikolsky, Doron Aronson
BACKGROUND: Acute kidney injury (AKI) following primary percutaneous coronary intervention (pPCI) is frequently interpreted as contrast-induced AKI but may result from other insults. We aimed to determine the causal association of contrast material exposure and the incidence of AKI following pPCI using a control group of propensity score-matched patients with ST-segment-elevation myocardial infarction who were not exposed to contrast material. METHODS AND RESULTS: We studied 2025 patients with ST-segment-elevation myocardial infarction who underwent pPCI and 1025 patients receiving fibrinolysis or no reperfusion who were not exposed to contrast material during the first 72 hours of hospital stay (control group)...
June 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28647551/factors-predicting-falls-and-mobility-outcomes-in-patients-with-stroke-returning-home-after-rehabilitation-who-are-at-risk-of-falling
#7
Mandy Man-Di Ng, Keith D Hill, Frances Batchelor, Elissa Burton
OBJECTIVE: To identify factors predicting falls and limited mobility in people with stroke at 12 months after returning home from rehabilitation. DESIGN: Observational cohort study with 12 month follow-up. SETTING: Community. PARTICIPANTS: People with stroke (n=144) and increased falls risk discharged home from rehabilitation. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Falls were measured using monthly calendars completed by participants, and mobility was assessed using gait speed over five metres (high mobility (>0...
June 21, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28647333/effects-of-bedding-with-recycled-sand-on-lying-behaviors-udder-hygiene-and-preference-of-lactating-holstein-dairy-cows
#8
J A Kull, H D Ingle, R A Black, N L Eberhart, P D Krawczel
Effects of bedding with recycled sand and season on lying behaviors, hygiene, and preferences of late-lactation Holstein cows were studied. It was hypothesized that recycled sand will decrease lying time and increase hygiene scores due to increased moisture content and organic matter, and thus a preference for the control sand will be evident. Cows (n = 64) were divided into 4 groups (n = 8 per group) per season. In summer (August to September), cows were balanced by days in milk (268.1 ± 11.9 d) and parity (2...
June 21, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28647326/effect-of-prepartum-energy-balance-on-neutrophil-function-following-pegbovigrastim-treatment-in-periparturient-cows
#9
S McDougall, S J LeBlanc, A Heiser
Treatment with granulocyte colony-stimulating factor (G-CSF) increases polymorphonuclear cell (neutrophil) count and enhances neutrophil function in the periparturient cow. Prepartum undernutrition was hypothesized to reduce the effect of a commercially available recombinant bovine G-CSF product (pegbovigrastim) on neutrophil count and function. Hence this study was undertaken to test the effect of undernutrition for approximately 1 mo before calving on the innate immune response to pegbovigrastim. Cows (n = 99) on pasture were blocked by expected calving date and body condition score and randomly assigned in a 2 × 2 factorial design...
June 21, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28647291/genistein-supplementation-improves-insulin-resistance-and-inflammatory-state-in-non-alcoholic-fatty-liver-patients-a-randomized-controlled-trial
#10
Sasan Amanat, Mohammad Hassan Eftekhari, Mohammad Fararouei, Kamran Bagheri Lankarani, Seyed Jalil Massoumi
BACKGROUND & AIMS: The beneficial effect of genistein has indicated on metabolic disorders and inflammatory state. The aim of this study was to investigate the effect of genistein supplementation on non-alcoholic fatty liver disease (NAFLD) as the hepatic manifest of metabolic syndrome. METHODS: In the present randomized double-blind controlled trial, patients with NAFLD were daily supplemented with either 250 mg genistein (n = 41) or placebo (n = 41) for 8-weeks...
June 1, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28647267/relationship-between-nutrients-and-plankton-biomass-in-the-turbidity-maximum-zone-of-the-pearl-river-estuary
#11
Zhen Shi, Jie Xu, Xiaoping Huang, Xia Zhang, Zhijian Jiang, Feng Ye, Ximei Liang
Nutrients, dissolved and particulate organic carbon and plankton (bacterio-, phyto- and zoo-) were compared in the turbidity maximum zone (TMZ) and adjacent areas (non-TMZ) in the Pearl River estuary. Our results showed that high levels of suspended substances had marked effect on dynamics of nutrients and plankton in the TMZ. Based on the cluster analysis of total suspended solids (TSS) concentrations, all stations were divided into two groups, TMZ with average TSS of 171mg/L and non-TMZ of 45mg/L. Suspended substances adsorbed PO4(3-) and dissolved organic carbon, resulting in higher particulate phosphorus and organic carbon (POC) and lower PO4(3-) and DOC in the TMZ, compared to the non-TMZ...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28647265/evaluation-of-co-metabolic-removal-of-trichloroethylene-in-a-biotrickling-filter-under-acidic-conditions
#12
Dhawal Chheda, George A Sorial
This study investigated the removal of hydrophobic trichloroethylene (TCE) in the presence of methanol (co-metabolite) in a biotrickling filter, which was seeded with fungi at pH4. Starvation was chosen as the biomass control strategy. Two systems, Biofilter I (methanol:TCE 70:30) and Biofilter II (methanol:TCE 80:20) were run in parallel, each with varying composition ratios. The TCE loading rates for both biofilters ranged from 3.22 to 12.88g/m(3)/hr. Depending on the ratio, methanol concentrations varied from 4...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28647247/spatial-variability-and-possible-sources-of-acetate-and-formate-in-the-surface-snow-of-east-antarctica
#13
Gautami Samui, Runa Antony, Kanthanathan Mahalinganathan, Meloth Thamban
Spatial trends of acetate (Ac(-)) and formate (Fo(-)) were determined in surface snow samples along a coastal-inland transect (180km) in the ice cap region at Princess Elizabeth Land and along a coastal transect in the Amery Ice Shelf (130km), East Antarctica. Variations in both Ac(-) and Fo(-) seem to be unrelated to the acidity of snow. Ionic balance determined for the snow samples indicate the availability of HNO3 that could undergo photolysis to produce hydroxyl radical (OH), one of the major reactants involved in oxidation reactions with organic matter...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28647236/hydrolysis-of-polyaluminum-chloride-prior-to-coagulation-effects-on-coagulation-behavior-and-implications-for-improving-coagulation-performance
#14
Zhongguo Zhang, Jun Wang, Dan Liu, Jiuyi Li, Xiaolin Wang, Boyu Song, Bing Yue, Kehui Zhao, Yun Song
The effects of polyaluminum chloride (PACl) hydrolysis prior to coagulation on both the coagulation zone and coagulation performance of a kaolin suspension were investigated by a novel jar test named the "reversed coagulation test". The tests showed that PACl hydrolysis prior to coagulation decreased the performance of charge neutralization coagulation in the case of short-time slow mixing (10min; G=15sec(-1)) and increased the optimal dosage for charge neutralization and sweep coagulation. Moreover, the hydrolysis time had insignificant effects on the size and zeta potential of PACl precipitates and the residual turbidity of the raw water...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28646866/engineering-redox-homeostasis-to-develop-efficient-alcohol-producing-microbial-cell-factories
#15
REVIEW
Chunhua Zhao, Qiuwei Zhao, Yin Li, Yanping Zhang
The biosynthetic pathways of most alcohols are linked to intracellular redox homeostasis, which is crucial for life. This crucial balance is primarily controlled by the generation of reducing equivalents, as well as the (reduction)-oxidation metabolic cycle and the thiol redox homeostasis system. As a main oxidation pathway of reducing equivalents, the biosynthesis of most alcohols includes redox reactions, which are dependent on cofactors such as NADH or NADPH. Thus, when engineering alcohol-producing strains, the availability of cofactors and redox homeostasis must be considered...
June 24, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28646842/fruit-and-vegetable-consumption-in-high-school-students-in-bandar-abbas-iran-an-application-of-the-trans-theoretical-model
#16
Sayed Hossein Davoodi, Zahra Hosseini, Teamur Aghamolaei, Mehdi Zare, Amin Ghanbarnejad
BACKGROUND: A diet rich in fruits and vegetables is of a great importance, especially to adolescents due to their need for nutrients and their rapid growth. The aim of this study was to investigate the relationship between decisional balance and self-efficacy with stages of change for fruit and vegetable consumption in high school students in Bandar Abbas, Iran. METHODS: In this descriptive-analytical study, data were collected from 345 students studying in eight high schools of Bandar Abbas who were selected through multistage sampling...
June 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28646745/automatic-postural-responses-are-generated-according-to-feet-orientation-and-perturbation-magnitude
#17
Nametala Maia Azzi, Daniel Boari Coelho, Luis Augusto Teixeira
This investigation aimed to assess the effect of feet orientation angle in upright stance on automatic postural responses (APRs) to mechanical perturbations of different magnitudes. Perturbation was produced by releasing suddenly a load attached to the participant's trunk, leading to forward body sway. We evaluated APRs to loads corresponding to 5% (low) and 10% (high) of the participant's body weight, comparing the following feet orientations: parallel, preferred (M=10.46°), 15° and 30° for each foot regarding the body midline...
June 21, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28646717/comprehending-the-multiple-values-of-green-infrastructure-valuing-nature-based-solutions-for-urban-water-management-from-multiple-perspectives
#18
T C Wild, J Henneberry, L Gill
The valuation of urban water management practices and associated nature-based solutions (NBS) is highly contested, and is becoming increasingly important to cities seeking to increase their resilience to climate change whilst at the same time facing budgetary pressures. Different conceptions of 'values' exist, each being accompanied by a set of potential measures ranging from calculative practices (closely linked to established market valuation techniques) - through to holistic assessments that seek to address wider concerns of sustainability...
June 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/28646711/effect-of-memantine-on-c-reactive-protein-and-lipid-profiles-in-bipolar-disorder
#19
Hui Hua Chang, Po See Chen, Tzu-Yun Wang, Sheng-Yu Lee, Shiou-Lan Chen, San-Yuan Huang, Jau-Shyong Hong, Yen Kuang Yang, Ru-Band Lu
BACKGROUND: Balance in the immune system plays roles in bipolar disorder (BD) and its metabolic co-morbidities. Memantine is an NMDA receptor antagonist with anti-inflammatory effects. However, the effects of memantine adjunct treatment on metabolic status of BD are unclear. METHODS: During the 12 weeks period, a total of 191 BD patients were enrolled and split into valproate (VPA) + placebo and VPA + memantine (5mg/day) arms. The fasting plasma levels of high-sensitivity C-reactive protein (CRP) and metabolic indices were assessed...
June 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28646680/the-experiences-of-supporting-learning-in-pairs-of-nursing-students-in-clinical-practice
#20
Hanna Holst, Lise-Lotte Ozolins, David Brunt, Ulrica Hörberg
The purpose of this study is to describe how supervisors experience supporting nursing students' learning in pairs on a Developing and Learning Care Unit in Sweden. The present study has been carried out with a Reflective Lifeworld Research (RLR) approach founded on phenomenology. A total of 25 lifeworld interviews were conducted with supervisors who had supervised pairs of students. The findings reveal how supervisors support students' learning in pairs through a reflective approach creating learning space in the encounter with patients, students and supervisors...
June 9, 2017: Nurse Education in Practice
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