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https://www.readbyqxmd.com/read/29244650/pharmacotherapy-for-obesity-what-you-need-to-know
#1
Sophie Bersoux, Tina H Byun, Swarna S Chaliki, Kenneth G Poole
Weight-loss drugs are being evaluated for their role in obesity management. This article reviews the available weight-loss drugs, their efficacy and side effects, and their best clinical use.
December 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29243457/the-surgical-management-of-obesity
#2
Samuel Torres-Landa, Umashankkar Kannan, Isabella Guajardo, Octavia E Pickett-Blakely, Daniel T Dempsey, Noel N Williams, Kristoffel R Dumon
Obesity is a spreading epidemic associated with significant morbidity and mortality with a prevalence of over 36% worldwide. In the face of a growing epidemic, increasing medical costs, and the disappointing limitations of medical and lifestyle modification bariatric surgery was found to consistently lead to significant weight loss and improvement in obesity-associated comorbidities when compared to non-surgical interventions. Bariatric procedures fall within three basic categories: restrictive procedures, malabsorptive procedures, and procedures that combine both restrictive and malabsorptive mechanisms...
December 14, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29243396/bariatric-surgery-induced-cardiac-and-lipidomic-changes-in-obesity-related-heart-failure-with-preserved-ejection-fraction
#3
Deana Mikhalkova, Sujata R Holman, Hui Jiang, Mohammed Saghir, Eric Novak, Andrew R Coggan, Robert O'Connor, Adil Bashir, Ali Jamal, Daniel S Ory, Jean E Schaffer, J Christopher Eagon, Linda R Peterson
OBJECTIVE: To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). METHODS: A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22)...
December 15, 2017: Obesity
https://www.readbyqxmd.com/read/29242854/state-estimation-under-correlated-partial-measurement-losses-implications-for-weight-control-interventions
#4
Penghong Guo, Daniel E Rivera, Jennifer S Savage, Danielle S Downs
The growing prevalence of obesity and related health problems warrants immediate need for effective weight control interventions. Quantitative energy balance models serve as powerful tools to assist in these interventions, as a result of their ability to accurately predict individual weight change based on reliable measurements of energy intake and energy expenditure. However, the data collected in most existing weight interventions is self-monitored; these measurements often have significant noise or experience losses resulting from participant non-adherence, which in turn, limits accurate model estimation...
July 2017: Proceedings of the IFAC World Congress
https://www.readbyqxmd.com/read/29242844/effects-of-increased-body-weight-and-short-term-weight-loss-on-serum-pcsk9-levels-a-prospective-pilot-study
#5
Theodosios D Filippatos, Evangelos Liberopoulos, Maria Georgoula, Constantinos C Tellis, Alexandros D Tselepis, Moses Elisaf
Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with low-density lipoprotein (LDL) catabolism, but its serum concentration is not uniformly associated with cardiovascular disease in clinical studies. Obesity is linked with increased cardiovascular risk, but the effect of increased body weight and short-term weight loss on serum PCSK9 levels is not well studied. Material and methods: The aim of this prospective pilot study was to assess differences in serum PCSK9 levels (determined with a quantitative sandwich enzyme immunoassay) between otherwise healthy drug-naïve obese subjects and healthy individuals with normal body weight...
2017: Archives of Medical Sciences. Atherosclerotic Diseases
https://www.readbyqxmd.com/read/29242563/ck2-modulates-adipocyte-insulin-signaling-and-is-up-regulated-in-human-obesity
#6
Christian Borgo, Gabriella Milan, Francesca Favaretto, Fabio Stasi, Roberto Fabris, Valentina Salizzato, Luca Cesaro, Anna Belligoli, Marta Sanna, Mirto Foletto, Luca Prevedello, Vincenzo Vindigni, Romeo Bardini, Arianna Donella-Deana, Roberto Vettor
Insulin plays a major role in glucose metabolism and insulin-signaling defects are present in obesity and diabetes. CK2 is a pleiotropic protein kinase implicated in fundamental cellular pathways and abnormally elevated in tumors. Here we report that in human and murine adipocytes CK2-inhibition decreases the insulin-induced glucose-uptake by counteracting Akt-signaling and GLUT4-translocation to the plasma membrane. In mice CK2 acts on insulin-signaling in adipose tissue, liver and skeletal muscle and its acute inhibition impairs glucose tolerance...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29241577/caulerpa-okamurae-extract-inhibits-adipogenesis-in-3t3-l1-adipocytes-and-prevents-high-fat-diet-induced-obesity-in-c57bl-6-mice
#7
Bhesh Raj Sharma, Hyun Jung Kim, Min Suk Kim, Chul Min Park, Dong Young Rhyu
Seaweeds are considered a potential source of antiobesity agents. Because Caulerpa, a seaweed, has been consumed for food in Japan, China, South Korea, and Australia, we hypothesized that Caulerpa okamurae may have antiobesity effects in an animal model of high-fat diet (HFD)-induced obesity in C57BL/6 mice. Herein, we found that the ethanolic extract of C okamurae (COE) significantly inhibited lipid accumulation and reduced the expression of the master regulator of adipogenesis, peroxisome proliferator-activated receptor-γ, sterol regulatory element binding protein-1c, and CCAAT/enhancer-binding protein-α in 3T3-L1 adipocytes...
November 2017: Nutrition Research
https://www.readbyqxmd.com/read/29241322/modulatory-effects-of-dietary-supplementation-by-vernonia-amygdalina-on-high-fat-diet-induced-obesity-in-wistar-rats
#8
Chima A Ekeleme-Egedigwe, Ifeoma I Ijeh, Polycarp N Okafor
BACKGROUND: Obesity is a growing public health problem arising from energy imbalance. The effect of 10% dietary incorporation of Vernonia amygdalina (VA) leaves into high-fat diets on some biological markers of adiposity and dyslipidaemia was investigated. METHODS: Experimental diets consisted of the following – CD (control diet); HFD (high-fat diet); and HFD- VA (HFD containing 10% Vernonia amygdalina leaves) supplementation. Fifteen male Wistar rats were randomly divided into three groups of five animals each...
October 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/29241051/determination-of-lipid-profiles-in-serum-of-obese-ponies-before-and-after-weight-reduction-by-using-multi-one-dimensional-thin-layer-chromatography
#9
Ratchada Auyyuenyong, Andrea Henze, Julia Ungru, Florian J Schweigert, Jens Raila, Ingrid Vervuert
Obesity is a key component of equine metabolic syndrome, which is highly associated with laminitis. Feed restriction and/or exercise are known to alleviate the detrimental effects of insulin resistance in obese ponies. However, little is known about changes in the serum lipid patterns due to weight reduction and its association with disease outcomes. Therefore, the lipid patterns in the serum of 14 mature ponies before and after a 14-week body weight reduction program (BWRP) were investigated by multi-one-dimensional thin-layer chromatography (MOD-TLC)...
November 21, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29239795/effects-of-very-low-calorie-diets-on-liver-size-and-weight-loss-in-the-preoperative-period-of-bariatric-surgery-a-systematic-review
#10
REVIEW
Mariana Holderbaum, Daniela Schaan Casagrande, Samanta Sussenbach, Caroline Buss
Restrictive diet implementation in bariatric surgery (BS) preoperative period is common, although its benefits are not well established. This study aimed to assess the effects of very low calorie diets (VLCD) on liver size and weight loss during BS preoperative period. Surgery-related complications were also assessed. A systematic review of the literature was performed. Terms such as "bariatric surgery" and "very low energy diet" were included in the search strategy. Inclusion criteria were adult patients (aged>18 yr); VLCD treatment in BS preoperative period (10 d to 12 wk); and assessment of 1 the following outcomes: weight loss, liver volume reduction, and surgical complications...
October 2, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29239469/bariatric-surgery-in-the-elderly-a-narrative-review
#11
Everton Cazzo, Martinho Antonio Gestic, Murillo Pimentel Utrini, Felipe David Mendonça Chaim, Francisco Callejas-Neto, José Carlos Pareja, Elinton Adami Chaim
INTRODUCTION: Due to population ageing, the elderly obese population is increasing. Bariatric surgery is the standard treatment option for morbid obesity nowadays, but there is some controversy regarding its routine indication in the elderly population. Objetive: To review the current evidence about bariatric surgery in the elderly. METHOD: On-line search in the electronic databases Medline and Lilacs and compilation of the most significant data. The most relevant studies in the area over the past 16 years have been considered for this review...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29238916/impact-of-bariatric-surgical-intervention-on-peripheral-blood-neutrophil-pbn-function-in-obesity
#12
Helen M Roberts, Melissa M Grant, Naomi Hubber, Paul Super, Rishi Singhal, Iain L C Chapple
AIM: The aim of this study was to investigate the impact of weight loss following gastric band surgery on multiple measures of peripheral blood neutrophil (PBN) function. MATERIAL AND METHODS: Twenty-three obese patients undergoing gastric band surgery were recruited to a longitudinal intervention study, alongside non-obese, healthy gender- and age-matched controls. Eighteen pairs of patients and controls completed all stages of the study. PBNs were isolated by density centrifugation and a comprehensive analysis of PBN function was undertaken at various stages of the patients' bariatric surgical care pathway...
December 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29237437/the-impact-of-a-community-led-program-promoting-weight-loss-and-healthy-living-in-aboriginal-communities-the-new-south-wales-knockout-health-challenge
#13
Erin Passmore, Brooke Shepherd, Andrew Milat, Louise Maher, Kiel Hennessey, Rachael Havrlant, Michelle Maxwell, Wendy Hodge, Fiona Christian, Justin Richards, Jo Mitchell
BACKGROUND: Aboriginal people in Australia experience significant health burden from chronic disease. There has been limited research to identify effective healthy lifestyle programs to address risk factors for chronic disease among Aboriginal people. METHODS: The Knockout Health Challenge is a community-led healthy lifestyle program for Aboriginal communities across New South Wales, Australia. An evaluation of the 2013 Knockout Health Challenge was undertaken. Participants' self-reported physical activity and diet were measured at four time points - at the start and end of the Challenge (via paper form), and 5 and 9 months after the Challenge (via telephone survey)...
December 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29237284/pain-worsening-with-physical-activity-during-migraine-attacks-in-women-with-overweight-obesity-a-prospective-evaluation-of-frequency-consistency-and-correlates
#14
Samantha G Farris, J Graham Thomas, Ana M Abrantes, Richard B Lipton, Jelena Pavlovic, Todd A Smitherman, Megan B Irby, Donald B Penzien, Julie Roth, Kevin C O'Leary, Dale S Bond
Background Migraine is a neurological disease involving recurrent attacks of moderate-to-severe and disabling head pain. Worsening of pain with routine physical activity during attacks is a principal migraine symptom; however, the frequency, individual consistency, and correlates of this symptom are unknown. Given the potential of this symptom to undermine participation in daily physical activity, an effective migraine prevention strategy, further research is warranted. This study is the first to prospectively evaluate (a) frequency and individual consistency of physical activity-related pain worsening during migraine attacks, and (b) potential correlates, including other migraine symptoms, anthropometric characteristics, psychological symptoms, and daily physical activity...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29237161/effects-of-intentional-weight-loss-on-markers-of-oxidative-stress-dna-repair-and-telomere-length-a-systematic-review
#15
Caroline Himbert, Henry Thompson, Cornelia M Ulrich
BACKGROUND: Altered levels of markers of oxidative stress, DNA repair, and telomere integrity have been detected in obese individuals and may underlie the pathogenesis of obesity-related diseases. However, whether or not such effects are reversed by intentional weight loss has not been systematically reviewed. METHODS: A literature search in PubMed/Medline identified 2,388 articles of which 21 studies (randomized controlled trial (RCT) (n = 10) and non-randomized intervention studies (n = 11)) were classified as testing the effects of intentional weight loss on i) oxidative stress (n = 15), ii) DNA repair (n = 2), and iii) telomere length (n = 4)...
December 14, 2017: Obesity Facts
https://www.readbyqxmd.com/read/29237132/anastomotic-stricture-rates-following-roux-en-y-gastric-bypass-for-morbid-obesity-a-comparison-between-linear-and-circular-stapled-anastomosis
#16
Harbi Khalayleh, Guy Pines, Ashraf Imam, Shimon Sapojnikov, Victor Buyeviz, Eli Mavor
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) is an effective procedure in the management of morbid obesity with variations in outcome, which are technique dependent. Anastomotic stricture remains an important complication. The aim of this study was to assess the long-term outcome of patients undergoing either a linear-stapled anastomosis (LSA) or circular-stapled anastomosis (CSA) with an emphasis on postoperative stricture formation and excess body weight loss (EBWL). METHODS: Medical records of all patients who underwent bariatric surgery between 2008 and 2013 at a single bariatric surgical center were reviewed...
December 13, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29235554/morning-and-afternoon-appetite-and-gut-hormone-responses-to-meal-and-stress-challenges-in-obese-individuals-with-and-without-binge-eating-disorder
#17
S Carnell, C Grillot, T Ungredda, S Ellis, N Mehta, J Holst, A Geliebter
BACKGROUND: Eating late in the day is common, and stress can induce eating. Little is understood about how time of day and stress interact to affect appetite and thereby body weight. These may be particularly important influences in binge eaters, who tend to binge in the evening, and in response to stress. METHOD: Obese participants with (n=16) and without (n=16) Binge Eating Disorder (BED) participated in two identical test protocols beginning either in the morning or the afternoon (AM condition/PM condition), each following an 8 h fast...
December 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29235180/the-effects-of-hypoglycemia-and-weight-loss-of-total-lignans-from-fructus-arctii-in-kkay-mice-and-its-mechanisms-of-the-activity
#18
Yingying Gao, Chenchen Gu, Kai Wang, Haiying Wang, Kefeng Ruan, Zhaohui Xu, Yi Feng
Fructus Arctii (great burdock achene) is the dried ripe fruit of Arctium lappa L. (family Asteraceae) and is included in the Chinese pharmacopoeia. It has been reported that the clinical use of Fructus Arctii resulted in a satisfactory hypoglycemic effect in diabetic patients. This study aimed to investigate antidiabetic activity and mechanism of total lignans from Fructus Arctii (TLFA) in KKAy mice, a spontaneous Type 2 diabetic rodent model that exhibits marked obesity. In this study, KKAy mice were gavaged once daily with solvents (0...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29235013/effects-of-weight-loss-on-acoustic-parameters-after-bariatric-surgery
#19
Lourdes Bernadete Rocha de Souza, Marquiony Marques Dos Santos, Leandro Araújo Pernambuco, Cynthia Meira de Almeida Godoy, Deysianne Meire da Silva Lima
BACKGROUND: Patients with morbid obesity may present vocal alterations, since large accumulation of fat in the vocal tract may interfere with voice production of these individuals. OBJECTIVE: Verify the neck circumference and the acoustic parameters of voice in obese women, before and after the bariatric surgery, and compare the results with a control group, with normal weight. METHODS: Observational, longitudinal, descriptive study with patients referred to the SCODE (Obesity Surgery and Related Disorders Center) in a university hospital...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29235011/comparative-effectiveness-of-laparoscopic-sleeve-gastrectomy-on-morbidly-obese-super-obese-and-super-super-obese-patients-for-the-treatment-of-morbid-obesity
#20
Ilhan Ece, Huseyin Yilmaz, Husnu Alptekin, Serdar Yormaz, Bayram Colak, Farise Yilmaz, Mustafa Sahin
BACKGROUNDS: The management of super-super obese patients is challenging for bariatric surgeons. Laparoscopic sleeve gastrectomy (LSG) is feasible as two-stage treatment for high-risk patients. However, its efficacy as a stand-alone procedure in super-super obese (SSO) patients is controversial. The study objective was to demonstrate the safety and efficacy of LSG in super-obese (SO) and SSO patients. METHODS: A retrospective analysis was performed of consecutive patients undergoing LSG...
December 12, 2017: Obesity Surgery
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