keyword
https://read.qxmd.com/read/38383361/impact-of-vitamin-d-supplementation-on-the-clinical-outcomes-of-covid-19-pneumonia-patients-a-single-center-randomized-controlled-trial
#21
JOURNAL ARTICLE
Pitchaya Dilokpattanamongkol, Chadakan Yan, Kulapong Jayanama, Pintip Ngamjanyaporn, Somnuek Sungkanuparph, Porpon Rotjanapan
BACKGROUND: Vitamin D supplementation for infectious diseases has been discussed, but its role in COVID-19 is unclear. Therefore, this study examined the clinical outcomes of COVID-19 pneumonia patients who received vitamin D supplementation. METHODS: This prospective, open-label, randomized controlled trial was conducted in a university hospital between July 2020 and March 2022. The inclusion criteria were patients aged ≥ 18 years with COVID-19 pneumonia patients...
February 21, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38381147/high-rates-of-intestinal-colonization-with-carbapenemase-producing-enterobacteriaceae-in%C3%A2-hematopoietic-stem-cell-transplant-recipients
#22
JOURNAL ARTICLE
Ikram Ayari, Yosra Chebbi, Anis Raddaoui, Dorra Belloumi, Siwar Frigui, Rim Werhni, Tarek Ben Othmen, Nour Abedejlil, Wafa Achour
Carbapenem resistant Enterobacteriaceae (CRE) are major human pathogens because, these cause high number of difficult-to-treat infections. Allogeneic hematopoietic stem cell transplant (AHSCT) recipients are highly exposed to these type of bacteria. The aim of our study was to investigate prevalence of CRE colonization in AHSCT patients and to determine genes encoding carbapenem resistance. A retrospective study conducted between January 2015 and December 2019, involved 55 patients colonized with CRE strains...
February 21, 2024: Acta Microbiologica et Immunologica Hungarica
https://read.qxmd.com/read/38380170/adjunct-acupuncture-improved-respiratory-status-and-weaning-from-mechanical-ventilation-after-severe-covid-19-pneumonia
#23
JOURNAL ARTICLE
Jun Matsumoto-Miyazaki, Hideshi Okada, Tomotaka Miura, Keisuke Kumada, Genki Naruse, Nagisa Miyazaki, Kodai Suzuki, Shozo Yoshida, Shinji Ogura, Hiroyuki Okura
BACKGROUND: A patient with severe COVID-19 pneumonia had adjunctive acupuncture to improve respiration and facilitate weaning off prolonged mechanical ventilation (MV). CASE: A man in his 40s with COVID-19 was in an advanced critical-care center on symptom day 5 for respiratory failure due to pneumonia requiring MV therapy. He received high-dose corticosteroid pulse therapy, antiviral agents, and multiple antibiotics for complicated bacterial pneumonia and bacteremia...
February 1, 2024: Medical Acupuncture
https://read.qxmd.com/read/38370292/hypoxemic-respiratory-failure-and-coccidioidomycosis-associated-acute-respiratory-distress-syndrome
#24
Arash Heidari, Simmer Kaur, Skyler J Pearson, Augustine Munoz, Harleen Sandhu, Gursimran Mann, Michael Schivo, Amir A Zeki, Derek J Bays, Machelle Wilson, Timothy E Albertson, Royce Johnson, George R Thompson
BACKGROUND: Severe coccidioidomycosis presenting with respiratory failure is an uncommon manifestation of disease. Current knowledge of this condition is limited to case reports and small case series. METHODS: A retrospective multicenter review of patients with coccidioidomycosis-associated acute respiratory distress syndrome (CA-ARDS) was conducted. It assessed clinical and laboratory variables at the time of presentation, reviewed the treatment course, and compared this cohort with a national database of patients with noncoccidioidomycosis ARDS...
February 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38369876/inhaled-corticosteroids-may-not-affect-the-clinical-outcomes-of-pneumonia-in-patients-with-chronic-obstructive-pulmonary-disease
#25
JOURNAL ARTICLE
Min-Seok Chang, In-So Cho, Iseul Yu, Sunmin Park, Seok Jeong Lee, Suk Joong Yong, Won-Yeon Lee, Sang-Ha Kim, Ji-Ho Lee
BACKGROUND: Although inhaled corticosteroids (ICS) is reportedly associated with a higher risk of pneumonia in chronic obstructive pulmonary disease (COPD), the clinical implications of ICS have not been sufficiently verified to determine their effect on the prognosis of pneumonia. METHODS: The electronic health records of patients hospitalized for pneumonia with underlying COPD were retrospectively reviewed. Pneumonia was confirmed using chest radiography or computed tomography...
February 19, 2024: Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38361963/prevalence-predictors-and-outcome-of-pulmonary-mucormycosis-in-covid-19-associated-rhino-orbital-mucormycosis-in-a-tertiary-care-center-in-south-india
#26
JOURNAL ARTICLE
Karthigeyan Thanjavur Sethuraman, Jayaraj Athimanjeri Thiruvengadam, Abinaya Ravichandran, Santhi Thoppappatty Sengottaiyan
BACKGROUND AND PURPOSE: India witnessed an explosive rise in mucormycosis following COVID-19 infection. Pulmonary mucormycosis closely followed rhino orbital mucormycosis as the most common presentation. The need for advanced resources and lack of clinical suspicion for COVID-19-associated pulmonary mucormycosis led to widespread underdiagnosis and poor response to late therapy. The present study aimed to assess the prevalence of pulmonary mucormycosis in COVID-19-associated rhino-orbital mucormycosis using non-invasive techniques, such as sputum microscopy and chest imaging...
September 2023: Current Medical Mycology
https://read.qxmd.com/read/38357050/blastomycosis-complicated-by-adult-respiratory-distress-syndrome-in-an-immunocompetent-adult-a-case-report-and-literature-review
#27
Alan M Furlan, Francisco F Costa Filho, Donald W Gusfa, Hansen M Tang, Benjamin S Avner
Blastomycosis is an endemic mycotic infection caused by inhalation of thermally dimorphic fungi from the genus Blastomyces . Blastomyces dermatitidis  is the species most related to human infection in the USA and North America. Adult respiratory distress syndrome (ARDS) is a rare complication of blastomycosis and is associated with high mortality. Due to its rarity, evidence-based guidelines for diagnosing and treating ARDS associated with blastomycosis are scarce. In this case presentation, a 22-year-old male with a history of chronic cannabis use presented with severe respiratory symptoms, initially treated as community-acquired pneumonia...
January 2024: Curēus
https://read.qxmd.com/read/38356590/the-application-of-nanoparticles-as-advanced-drug-delivery-systems-in-attenuating-copd
#28
REVIEW
Victoria Jessamine, Samir Mehndiratta, Gabriele De Rubis, Keshav Raj Paudel, Saritha Shetty, Divya Suares, Dinesh Kumar Chellappan, Brian G Oliver, Phillip M Hansbro, Kamal Dua
Chronic Obstructive Pulmonary Disease (COPD) is a dilapidating condition which is characterized by inflammation, an excess in free radical generation and airway obstruction. Currently, the drugs commercially available for the management of COPD pose several limitations such as systemic adverse effects, including bone density loss and an increased risk of developing pneumonia. Moreover, another limitation includes the need for regular and frequent dosing regimens; which can affect the adherence to the therapy...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38354995/comparing-the-efficacy-of-corticosteroids-among-patients-with-community-acquired-pneumonia-in-the-icu-versus-non-icu-settings-a-systematic-review-and-meta-analysis
#29
JOURNAL ARTICLE
Luis A Diaz Caballero, Ashnah Aijaz, Neha Saleem Paryani, Samar Mahmood, Madiha Salman, Mohammad Omer Khan, Dayal Ahluwalia, Mohammad Arham Siddiq, Ishaque Hameed
BACKGROUND: Despite the potential of corticosteroids in treating community-acquired pneumonia (CAP), conflicting evidence exists regarding their effect on mortality. To address this gap and provide new insights, we conducted a pre-specified subgroup meta-analysis of corticosteroid use in CAP patients, focusing on the ICU versus non-ICU subsets. METHODS: We searched PubMed, Cochrane Central Register of Controlled Trials and SCOPUS from inception to May 2023 for randomized controlled trials (RCTs)...
February 12, 2024: Steroids
https://read.qxmd.com/read/38344468/trifluridine-and-tipiracil-hydrochloride-combination-induced-interstitial-pneumonia-a-case-report
#30
Shun Nakazawa, Motoyasu Kato, Yuriko Terayama, Naho Sakamoto Matubara, Yoshihiko Sato, Ryoko Murashima, Daisuke Hayakawa, Shouichi Okamoto, Kazuhisa Takahashi
We report a case of a 62-year-old male who was diagnosed with advanced rectal cancer. The attending gastro-enterologist initiated chemotherapy using capecitabine plus oxaliplatin and bevacizumab; however, this treatment regimen was discontinued, as the patient developed a skin rash. Once the skin rash improved, chemotherapy was re-initiated using a combination of trifluridine and tipiracil hydrochloride (TAS-102). The patient developed high fever and dyspnea 2 months after initiation of TAS-102. Chest high-resolution computed tomography showed bilateral diffuse ground glass opacities in all lung lobes with traction bronchiectasis...
2024: International Medical Case Reports Journal
https://read.qxmd.com/read/38331769/monoclonal-antibodies-in-idiopathic-chronic-eosinophilic-pneumonia-a-scoping-review
#31
JOURNAL ARTICLE
Andrea Dionelly Murillo, Ana Isabel Castrillon, Carlos Daniel Serrano, Liliana Fernandez-Trujillo
BACKGROUND: Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare disease characterized by pulmonary radiological alterations, peripheral eosinophilia, and demonstrated pulmonary eosinophilia. Oral steroids (OSs) are the standard management, but relapses occur in up to 50% of patients during the decrease or suspension of steroids, usually requiring reinitiation of treatment, exposing patients to secondary events derived from the management. Management with monoclonal antibodies has been proposed in these cases to control the disease and limit the secondary effects...
February 8, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38330061/pneumocystis-jirovecii-pneumonia-mortality-risk-associated-with-preceding-long-term-steroid-use-for-the-underlying-disease-a-multicenter-retrospective-cohort-study
#32
MULTICENTER STUDY
Kohei Miyake, Satoru Senoo, Ritsuya Shiiba, Junko Itano, Goro Kimura, Tatsuyuki Kawahara, Tomoki Tamura, Kenichiro Kudo, Tetsuji Kawamura, Yasuharu Nakahara, Hisao Higo, Daisuke Himeji, Nagio Takigawa, Nobuaki Miyahara
OBJECTIVE: Long-term steroid use increases the risk of developing Pneumocystis pneumonia (PcP), but there are limited reports on the relation of long-term steroid and PcP mortality. METHODS: Retrospective multicenter study to identify risk factors for PcP mortality, including average steroid dose before the first visit for PcP in non-human immunodeficiency virus (HIV)-PcP patients. We generated receiver operating characteristic (ROC) curves for 90-day all-cause mortality and the mean daily steroid dose per unit body weight in the preceding 10 to 90 days in 10-day increments...
2024: PloS One
https://read.qxmd.com/read/38328630/bird-related-non-fibrotic-hypersensitivity-pneumonitis-with-bronchoalveolar-lavage-fluid-eosinophilia-that-developed-after-covid-19-vaccination-a-case-report
#33
Takuma Katano, Tomoyuki Ogisu, Akira Satou, Toshiyuki Yonezawa, Hiroyuki Tanaka, Satoru Ito
A 60-year-old man who had been keeping seven budgerigars and four cockatiels in his house for 2 years developed dyspnea and was admitted to our hospital the day after receiving the second dose of the messenger RNA coronavirus disease 2019 vaccination. Chest high resolution computed tomography (HRCT) showed bilateral ground glass opacities without nodules or mosaic attenuation. IgG specific for budgerigars was positive. Although his respiratory symptoms were resolved without corticosteroid therapy, he developed severe dyspnea soon after the discharge to his home...
February 2024: Respirology Case Reports
https://read.qxmd.com/read/38312215/the-global-and-regional-prevalence-of-hospital-acquired-carbapenem-resistant-klebsiella-pneumoniae-infection-a-systematic-review-and-meta-analysis
#34
REVIEW
Xing-Chen Lin, Chang-Li Li, Shao-Yang Zhang, Xiao-Feng Yang, Meng Jiang
BACKGROUND: Due to scarce therapeutic options, hospital-acquired infections caused by Klebsiella pneumoniae (KP), particularly carbapenem-resistant KP (CRKP), pose enormous threat to patients' health worldwide. This study aimed to characterize the epidemiology and risk factors of CRKP among nosocomial KP infections. METHOD: MEDLINE, Embase, PubMed, and Google Scholar were searched for studies reporting CRKP prevalence from inception to 30 March 2023. Data from eligible publications were extracted and subjected to meta-analysis to obtain global, regional, and country-specific estimates...
February 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38311783/the-effectiveness-of-glucocorticoid-treatment-in-post-covid-19-pulmonary-involvement
#35
JOURNAL ARTICLE
Jan Mizera, Samuel Genzor, Milan Sova, Ladislav Stanke, Radim Burget, Petr Jakubec, Martin Vykopal, Pavol Pobeha, Jana Zapletalová
RATIONALE: Persistent respiratory symptoms following Coronavirus Disease 2019 (COVID-19) are associated with residual radiological changes in lung parenchyma, with a risk of development into lung fibrosis, and with impaired pulmonary function. Previous studies hinted at the possible efficacy of corticosteroids (CS) in facilitating the resolution of post-COVID residual changes in the lungs, but the available data is limited. AIM: To evaluate the effects of CS treatment in post-COVID respiratory syndrome patients...
February 5, 2024: Pneumonia
https://read.qxmd.com/read/38311715/association-between-oral-corticosteroid-starting-dose-and-the-incidence-of-pneumonia-in-japanese-patients-with-ulcerative-colitis-a-nation-wide-claims-database-study
#36
JOURNAL ARTICLE
Katsuyoshi Matsuoka, Tomoyuki Inoue, Hiroaki Tsuchiya, Katsumasa Nagano, Toshiyuki Iwahori
BACKGROUND/AIMS: A previous study demonstrated that half of patients started oral corticosteroids (OCS) for ulcerative colitis (UC) exacerbations at lower doses than recommended by Japanese treatment guidelines (initial OCS prednisolone equivalent dose, 30-40 mg). This may relate to physician's concern about infection, especially pneumonia including Pneumocystis jirovecii pneumonia (PJP), from high OCS doses. We assessed whether pneumonia incidence is increased with guideline-recommended OCS initial doses...
February 6, 2024: Intestinal Research
https://read.qxmd.com/read/38310918/hydrocortisone-plus-fludrocortisone-for-community-acquired-pneumonia-related-septic-shock-a-subgroup-analysis-of-the-aprocchss-phase-3-randomised-trial
#37
JOURNAL ARTICLE
Nicholas Heming, Alain Renault, Emmanuelle Kuperminc, Christian Brun-Buisson, Bruno Megarbane, Jean-Pierre Quenot, Shidasp Siami, Alain Cariou, Xavier Forceville, Carole Schwebel, Marc Leone, Jean-Francois Timsit, Benoît Misset, Mohamed Ali Benali, Gwenhael Colin, Bertrand Souweine, Karim Asehnoune, Emmanuelle Mercier, Loïc Chimot, Claire Charpentier, Bruno François, Thierry Boulain, Frank Petitpas, Jean Michel Constantin, Gilles Dhonneur, François Baudin, Alain Combes, Julien Bohé, Jean-François Loriferne, Fabrice Cook, Michel Slama, Olivier Leroy, Gilles Capellier, Auguste Dargent, Tarik Hissem, Rania Bounab, Virginie Maxime, Pierre Moine, Eric Bellissant, Djillali Annane
BACKGROUND: Glucocorticoids probably improve outcomes in patients hospitalised for community acquired pneumonia (CAP). In this a priori planned exploratory subgroup analysis of the phase 3 randomised controlled Activated Protein C and Corticosteroids for Human Septic Shock (APROCCHSS) trial, we aimed to investigate responses to hydrocortisone plus fludrocortisone between CAP and non-CAP related septic shock. METHODS: APROCCHSS was a randomised controlled trial that investigated the effects of hydrocortisone plus fludrocortisone, drotrecogin-alfa (activated), or both on mortality in septic shock in a two-by-two factorial design; after drotrecogin-alfa was withdrawn on October 2011, from the market, the trial continued on two parallel groups...
February 1, 2024: Lancet Respiratory Medicine
https://read.qxmd.com/read/38310916/corticosteroids-in-septic-shock-secondary-to-community-acquired-pneumonia-clarity-mixed-with-uncertainty
#38
JOURNAL ARTICLE
Balasubramanian Venkatesh, Jeremy Cohen
No abstract text is available yet for this article.
February 1, 2024: Lancet Respiratory Medicine
https://read.qxmd.com/read/38309961/-clinical-analysis-of-covid-19-in-patients-with-preexisting-interstitial-lung-abnormalities
#39
JOURNAL ARTICLE
Y J Shi, R X Chen, X N Liu, C Shao, H Huang, K Xu, M Z Wang, Z J Xu
Objective: To describe the clinical characteristics of SARS-CoV-2 infected patients with interstitial lung abnormalities (ILA) during the COVID-19 pandemic. Methods: We respectively enrolled ILA patients who had been regularly followed up in Peking Union Medical College Hospital for more than six months since January 2021. Clinical data of these ILA patients were collected after the outbreak of COVID-19 pandemic (from December 2022 to January 2023), thirty-eight patients with preexisting ILA were enrolled. Among them, there were 34 ILA patients (20 males and 14 females) who were infected with SARS-CoV-2 during this period, with an average age of (64...
February 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38308277/isolated-respiratory-tract-microorganisms-and-clinical-characteristics-in-asthma-exacerbation-of-obese-patients-a-multicenter-study
#40
MULTICENTER STUDY
Sojung Park, Yong Il Hwang, Sei Won Lee, Hyo-Jung Kim, Byung-Keun Kim, Jin Hwa Lee, Yon Ju Ryu, So Ri Kim, Jung Hyun Chang
BACKGROUND: Viral infection is a risk factor for asthma exacerbation (AE). However, bacterial infections related to AE in adults are poorly known. On the other hand, obese patients with asthma have their own clinical and biological characteristics compared with non-obese patients. METHODS: We investigated the differences in isolated pathogens for AE between obese and non-obese patients with asthma. We included 407 patients with AE from 24 medical centers in Korea...
February 2, 2024: BMC Pulmonary Medicine
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