keyword
https://read.qxmd.com/read/38482223/two-autopsied-gastric-cancer-cases-of-rare-drug-induced-pneumonia-associated-with-nivolumab-plus-s-1-and-oxaliplatin-a-case-report
#1
Taku Noumi, Shoka Kimura, Takuro Fushimi, Shuichi Sakamoto, Kayo Nakamura, Soichiro Fushimi, Toshiaki Ohara, Shuko Mashimo, Hiroyuki Tao, Takanori Watanabe, Daizo Kishino
BACKGROUND: Drug-induced pneumonia, especially immune-related adverse events, can sometimes be fatal, and it is crucial to seize the signs for early treatment. A clinical trial (ATTRACTION-4) reported no cases of grade 4 or 5 pneumonia or interstitial lung disease associated with nivolumab plus S-1 and oxaliplatin. However, we encountered two cases of fatal pneumonia induced by this regimen. CASE DESCRIPTION: The two patients were in their 70s, male and diagnosed gastric cancer with peritoneal dissemination...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38468588/a-rare-ocular-manifestation-of-mycoplasma-pneumoniae-infection
#2
JOURNAL ARTICLE
Sonda Kammoun, Mona Rekik, Kmar Maaloul, Saloua Ben Amor, Amira Trigui
INTRODUCTION: Ocular manifestations of Mycoplasma Pneumoniae infection are rare. We present a case of Mycoplasma Pneumoniae infection revealed by a recurrent retro-bulbar optic neuritis. CASE DESCRIPTION: A 38-year-old woman, initially treated for a typical retro-bulbar optic neuritis of the right eye with corticosteroid therapy at high doses, presented for a recurrent decreased vision in the same eye, associated with blepharospasm and conjunctival hyperemia. The etiological assessment revealed a recent Mycoplasma Pneumoniae infection...
November 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38468247/efficacy-and-safety-of-low-dose-corticosteroids-combined-with-leflunomide-for-progressive-iga-nephropathy-a-systematic-review-and-meta-analysis
#3
JOURNAL ARTICLE
Dongxu Zhang, Bowen Xia, Xin Zhang, Pu Liang, Xiaopeng Hu
BACKGROUND AND OBJECTIVE: The effectiveness of immunosuppressive and corticosteroid treatments for Immunoglobulin A (IgA) nephropathy (IgAN) remains thoroughly evaluated. We undertook a meta-analysis to investigate the efficacy and safety of low-dose corticosteroids plus leflunomide for progressive IgA nephropathy. METHODS: Eligible studies were obtained from PubMed, Embase, and Cochrane Library databases. We also searched the references of the included studies...
March 11, 2024: BMC Urology
https://read.qxmd.com/read/38465762/hypereosinophilic-syndrome-associated-with-multiple-thromboses-requiring-icu-admission-a-case-report
#4
JOURNAL ARTICLE
Islem Ouanes, Sarra Toumi, Yasser Ben Cheikh, Oussama Ben Rejeb, Nadia Mama
Hypereosinophilic syndrome (HES) is a leucoproliferative disorder, characterized by marked blood eosinophilia and organ damage due to tissue eosinophilia. Pulmonary involvement may lead to life-threatening acute respiratory failure and intensive care unit (ICU) admission. Association between eosinophilia and thromboembolism has been previously described. However, simultaneous venous and arterial thromboses are less reported. We report a case of a 25-year-old man, admitted to the ICU and developed acute respiratory failure, laboratory tests revealed hyperleukocytosis (39,700 /µL) with high eosinophil count (27393 /µl), Computed tomographic (CT) pulmonary angiography on admission showed a right pulmonary embolism and foci of splenic infarctions...
October 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38464245/biological-effects-of-corticosteroids-on-pneumococcal-pneumonia-in-mice-and-humans
#5
Hiroki Taenaka, Katherine D Wick, Aartik Sarma, Shotaro Matsumoto, Rajani Ghale, Xiaohui Fang, Mazharul Maishan, Jeffrey E Gotts, Charles R Langelier, Carolyn S Calfee, Michael A Matthay
Background: Streptococcus pneumoniae is the most common bacterial cause of community acquired pneumonia and the acute respiratory distress syndrome (ARDS). Some clinical trials have demonstrated a beneficial effect of corticosteroid therapy in community acquired pneumonia, COVID-19, and ARDS, but the mechanisms of this benefit remain unclear. The objective of this study was to investigate the effects of corticosteroids on the pulmonary biology of pneumococcal pneumonia in an observational cohort of mechanically ventilated patients and in a mouse model of bacterial pneumonia with Streptococcus pneumoniae ...
February 21, 2024: Research Square
https://read.qxmd.com/read/38462453/effect-of-dexamethasone-on-adhesion-of-human-neutrophils-and-concomitant-secretion
#6
JOURNAL ARTICLE
Svetlana I Galkina, Ekaterina A Golenkina, Natalia V Fedorova, Alexander L Ksenofontov, Marina V Serebryakova, Vladimir I Stadnichuk, Ludmila A Baratova, Galina F Sud'ina
Neutrophils play a dual role in protecting the body. They are able to penetrate infected tissues and destroy pathogens there by releasing aggressive bactericidal substances. While into the surrounding tissues, the aggressive products secreted by neutrophils initiate development of inflammatory processes. Invasion of neutrophils into tissues is observed during the development of pneumonia in the patients with lung diseases of various etiologies, including acute respiratory distress syndrome caused by coronavirus disease...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38456027/presumptive-pulmonary-toxocariasis-in-a-patient-affected-by-acute-myeloid-leukemia-and-hodgkin-lymphoma-case-report-and-review-of-the-literature-in-immunocompromised-hosts
#7
Tommaso Lupia, Elena Crisà, Valentina Sangiorgio, Roberta Bosio, Giacomo Stroffolini, Elena Staffilano, Vanesa Gregorc, Silvia Corcione, Francesco Giuseppe De Rosa
Toxocariasis is a zoonosis transmitted by the nematode Toxocara spp. Immunocompromised hosts are more susceptible than general population to bacterial, viral, fungal and parasitic infections. In this population toxocariasis may present as exacerbation or reactivation and could have severe or atypical manifestations being a diagnostic challenge for healthcare providers. We report a case of a presumptive pulmonary toxocariasis during chemotherapy in a patient affected by acute myeloid leukaemia (AML) and Hodgkin lymphoma and we summarize current evidence of pulmonary involvement in immunocompromised population with Toxocara spp infection in a narrative review...
2024: Le Infezioni in Medicina
https://read.qxmd.com/read/38455702/the-first-report-of-candida-auris-infection-in-vietnam
#8
JOURNAL ARTICLE
Thong Dang-Vu, Dung Lam-Quoc, Ngoc Duong-Minh, Ha Vu, Lam Nguyen-Ho, Phu Truong-Thien, Khoa Nguyen-Dang
UNLABELLED: Infection caused by Candida auris ha C. auris s rapidly become a global health threat. C. auris created a significant healthcare burden due to various complicating factors, including misidentification by commercial identification methods, potent antifungal resistance, high mortality rates and the possibility of nosocomial outbreaks through direct contact. In Vietnam, there are currently no clinical reports on C. auris infections. Here, we present four clinical cases of C. auris infections in the Department of Pulmonary Medicine of Cho Ray Hospital in southern Vietnam...
2024: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38448862/hospital-admission-rates-and-related-outcomes-among-adult-aboriginal-australians-with-bronchiectasis-a-ten-year-retrospective-cohort-study
#9
JOURNAL ARTICLE
Timothy Howarth, Claire Gibbs, Subash S Heraganahally, Asanga Abeyaratne
BACKGROUND: This study assessed hospitalisation frequency and related clinical outcomes among adult Aboriginal Australians with bronchiectasis over a ten-year study period. METHOD: This retrospective study included patients aged ≥ 18 years diagnosed with bronchiectasis between 2011 and 2020 in the Top End, Northern Territory of Australia. Hospital admissions restricted to respiratory conditions (International Classification of Diseases (ICD) code J) and relevant clinical parameters were assessed and compared between those with and without hospital admissions...
March 6, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38448171/-a-case-of-follicular-lymphoma-with-recurrent-fever-and-pulmonary-infiltrates
#10
JOURNAL ARTICLE
R X Chen, Y L Mai, K N Shen, T Zhang, J H Shi, Y L Yang
We reported a case of a 65-year-old male who had been treated with obinutuzumab and chemotherapy for follicular lymphoma. He was infected with SARS-CoV-2 after the second course of therapy. He developed fever, cough and bilateral pulmonary infiltrates. His nasopharyngeal swab became negative only temporarily after repeated courses of antiviral therapy, and the symptoms and pulmonary infiltrates waxed and waned. He presented to our hospital with exertional dyspnea and hypoxemia after his nasopharyngeal swab was positive for SARS-CoV-2 for the fourth time...
March 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38448169/-clinical-features-and-prognostic-analysis-of-checkpoint-inhibitor-pneumonitis-in-patients-with-non-small-cell-lung-cancer
#11
JOURNAL ARTICLE
R X Chen, X N Liu, Y Xu, Y J Shi, M Q Wang, C Shao, H Huang, K Xu, M Z Wang, Z J Xu
Objective: To describe the clinical characteristics of patients with non-small cell lung cancer (NSCLC) who developed checkpoint inhibitor pneumonitis (CIP) and to explore potential prognostic factors. Methods: NSCLC patients who were complicated with CIP after immune checkpoint inhibitors (ICIs) therapy in our institute were enrolled in this study from 1 July 2018 to 30 November 2022. Clinical data of NSCLC-CIP patients were collected, including clinical and radiological features and their outcomes. Results: Among the 70 enrolled NSCLC-CIP patients, there were 57 males (81%) and 13 females (19%)...
March 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38446336/association-between-increased-risk-of-pneumonia-with-ics-in-copd-a-continuous-variable-analysis-of-patient-factors-from-the-impact-study
#12
JOURNAL ARTICLE
Bhumika Aggarwal, Paul Jones, Alejandro Casas, Mauro Gomes, Siwasak Juthong, Diego Litewka, Bernice Ong-Dela Cruz, Alejandra Ramirez-Venegas, Abdullah Sayiner, James van Hasselt, Chris Compton, Lee Tombs, Stephen Weng, Gur Levy
INTRODUCTION: Despite the proven benefits of inhaled corticosteroid (ICS)-containing triple therapy for chronic obstructive pulmonary disease (COPD), clinicians limit patient exposure to ICS due to the risk of pneumonia. However, there are multiple factors associated with the risk of pneumonia in patients with COPD. This post hoc analysis of IMPACT trial data aims to set the risks associated with ICS into a context of specific patient-related factors that contribute to the risk of pneumonia...
March 6, 2024: Pulmonary Therapy
https://read.qxmd.com/read/38444989/corticosteroid-treatment-for-persistent-pulmonary-infiltrates-following-covid-19-infection-clearing-the-fog
#13
JOURNAL ARTICLE
Prince Ntiamoah, Michelle Biehl, Victoria Ruesch, Atul C Mehta, Samar Farha
BACKGROUND: Systemic corticosteroids have been shown to improve outcomes in severe coronavirus disease 2019 (COVID-19) pneumonia; however, their role in post-COVID-19 persistent lung abnormalities is not well defined. Here, we describe our experience with corticosteroids in patients with persistent lung infiltrates following COVID-19 infection. RESEARCH QUESTION: What is the efficacy of systemic corticosteroids in improving lung function and radiological abnormalities in patients following COVID-19 pneumonia? STUDY DESIGN AND METHODS: This is a single-center retrospective study evaluating patients with persistent respiratory symptoms and abnormal chest computed tomography findings...
2024: Annals of Thoracic Medicine
https://read.qxmd.com/read/38432039/corticosteroid-in-non-covid-19-induced-community-acquired-pneumonia-a-meta-analysis
#14
JOURNAL ARTICLE
Jian Liu, Yongquan Dong, Jia Chen, Yuqing Jin, Yunqing Qiu, Lingtong Huang
BACKGROUND: Corticosteroid treatment in non-COVID-19 induced Community-acquired pneumonia (CAP) remains inconclusive. OBJECTIVES: We aimed to assess the role of corticosteroid treatment in CAP. METHODS: We conducted a comprehensive search of online databases, including PubMed, Embase, and Cochrane, to identify articles published from January 1, 2000, to May 5, 2023. Double-blind RCTs were selected. Two authors screened studies and extracted data...
March 2, 2024: Heart & Lung: the Journal of Critical Care
https://read.qxmd.com/read/38430143/the-complications-of-corticosteroid-for-patients-with-community-acquired-pneumonia-a-systematic-review-and-meta-analysis
#15
JOURNAL ARTICLE
Donglan Wang, Yan Zhu
BACKGROUND: Many randomized controlled trials (RCTs) have reported the complications of corticosteroids for patients with community-acquired pneumonia with inconsistent results. An explicit systematic review and meta-analysis were conducted in this study to evaluate the complications of corticosteroids for patients with community-acquired pneumonia. METHODS: Using PubMed, Embase, the Global Index Medicus of the World Health Organization (WHO), the WHO clinical trial registry, and Clinicaltrials...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38407673/circulatory-inflammatory-proteins-as-early-diagnostic-biomarkers-for-invasive-aspergillosis-in-patients-with-hematologic-malignancies-an-exploratory-study
#16
JOURNAL ARTICLE
Robina Aerts, Isis Ricaño-Ponce, Mariolina Bruno, Toine Mercier, Diletta Rosati, Johan Maertens, Vinod Kumar, Agostinho Carvalho, Mihai G Netea, Martin Hoenigl
OBJECTIVES: Invasive aspergillosis (IA) is a major cause of mortality in immunocompromised patients and it is difficult to diagnose because of the lack of reliable highly sensitive diagnostics. We aimed to identify circulating immunological markers that could be useful for an early diagnosis of IA. METHODS: We collected longitudinally serum samples from 33 cases with probable/proven IA and two matched control cohorts without IA (one with microbiological and clinical evidence of bacterial or viral non-fungal pneumonia and one without evidence of infection, all matched for neutropenia, primary underlying disease, and receipt of corticosteroids/other immunosuppressants) at a tertiary university hospital...
February 26, 2024: Mycopathologia
https://read.qxmd.com/read/38406039/a-case-of-pneumocystis-pneumonia-developed-during-rheumatoid-arthritis-treatment-with-methotrexate-and-golimumab
#17
Toyoshi Yanagihara, Yusuke Oka, Atushi Moriwaki, Yuki Moriuchi, Hiroaki Ogata, Akiko Ishimatsu, Junji Otsuka, Kazuhito Taguchi, Makoto Yoshida
Here, we report a case of an 87-year-old female patient with rheumatoid arthritis (RA) treated with methotrexate (MTX) and golimumab who developed severe pneumocystis pneumonia (PCP), also known as Pneumocystis jirovecii  pneumonia. The patient presented with chief complaints of dyspnea on exertion, dry cough, and fatigue. A high-resolution chest CT scan revealed diffuse, unevenly distributed ground-glass opacities throughout both lungs. The patient was clinically diagnosed with PCP based on the clinical settings, imaging, and a high level of serum β-D-glucan...
January 2024: Curēus
https://read.qxmd.com/read/38397432/inhaled-corticosteroids-in-subjects-with-chronic-obstructive-pulmonary-disease-an-old-unfinished-history
#18
REVIEW
Andrea S Melani, Sara Croce, Gaia Fabbri, Maddalena Messina, Elena Bargagli
Chronic obstructive pulmonary disease (COPD) is one of the major causes of disability and death. Maintenance use of inhaled bronchodilator(s) is the cornerstone of COPD pharmacological therapy, but inhaled corticosteroids (ICSs) are also commonly used. This narrative paper reviews the role of ICSs as maintenance treatment in combination with bronchodilators, usually in a single inhaler, in stable COPD subjects. The guidelines strongly recommend the addition of an ICS in COPD subjects with a history of concomitant asthma or as a step-up on the top of dual bronchodilators in the presence of hospitalization for exacerbation or at least two moderate exacerbations per year plus high blood eosinophil counts (≥300/mcl)...
February 6, 2024: Biomolecules
https://read.qxmd.com/read/38395471/critical-deterioration-of-chronic-eosinophilic-pneumonia-during-pregnancy
#19
JOURNAL ARTICLE
Jake Vernon-Elliot, Jyotika Devi Prasad, Asha Bonney
Chronic eosinophilic pneumonia (CEP) is a rare, idiopathic interstitial lung disease characterised by the accumulation of eosinophils in the pulmonary interstitia and alveoli. Patients with CEP respond well to systemic corticosteroid therapy and infrequently progress to end-stage lung disease. We report a case of a woman in her 40s with previously stable, steroid-responsive CEP who experienced a critical deterioration of her CEP at 25 weeks of gestation during her third pregnancy. The patient was admitted to the intensive care unit due to respiratory failure requiring intubation and mechanical ventilation...
February 23, 2024: BMJ Case Reports
https://read.qxmd.com/read/38394455/correction-to-shifting-tides-is-it-time-to-embrace-adjunctive-corticosteroids-for-community-acquired-pneumonia
#20
(no author information available yet)
No abstract text is available yet for this article.
February 23, 2024: Clinical Infectious Diseases
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