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corticosteroids pneumonia

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https://www.readbyqxmd.com/read/28938676/risk-factors-for-mortality-from-pneumocystis-carinii-pneumonia-pcp-in-non-hiv-patients-a-meta-analysis
#1
Yao Liu, Lili Su, Shu-Juan Jiang, Hui Qu
The number of patients with non-human immunodeficiency virus (HIV) related pneumocystis carinii pneumonia (PCP) is increasing with widespread immunosuppressive treatment. We performed a meta-analysis to describe the clinical characteristics and factors associated with outcomes of PCP in HIV-negative patients. A total of 13 studies including 867 patients with non-HIV related PCP was included. The overall mortality for non-HIV patients with PCP was 30.6%. The most common underlying disorder for the development of PCP is hematological malignancies (29...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28931659/the-risk-of-mycobacterial-infections-associated-with-inhaled-corticosteroid-use
#2
Sarah K Brode, Michael A Campitelli, Jeffrey C Kwong, Hong Lu, Alex Marchand-Austin, Andrea S Gershon, Frances B Jamieson, Theodore K Marras
Inhaled corticosteroid (ICS) use is associated with an increased risk of pneumonia. This study was performed to determine if ICS use is associated with an increased risk of nontuberculous mycobacterial pulmonary disease (NTM-PD) or tuberculosis (TB).We conducted a population-based nested case-control study using linked laboratory and health administrative databases in Ontario, Canada, including adults aged ≥66 years with treated obstructive lung disease (i.e. asthma, chronic obstructive pulmonary disease (COPD) or asthma-COPD overlap syndrome) between 2001 and 2013...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28883249/pneumonitis-with-diffuse-alveolar-hemorrhage-induced-by-sho-seiryu-to
#3
Kazuo Tsuchiya, Mikio Toyoshima, Takafumi Suda
A 78-year-old man presented with acute-onset fever and dyspnea. He had been taking Sho-seiryu-to for allergic rhinitis. A chest radiograph showed diffuse bilateral ground-glass opacities with subpleural sparing, crazy-paving pattern, and traction bronchiectasis. The patient's bronchoalveolar lavage fluid was bloody and transbronchial lung biopsy specimens showed alveolitis, organizing pneumonia, and type 2 alveolar epithelial cell proliferation. There were no clinical and laboratory findings suggestive of respiratory tract infection or connective tissue disease...
September 6, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28879093/refractory-acute-respiratory-failure-due-to-pneumocystis-jiroveci-pcp-and-cytomegalovirus-cmv-pneumonitis-a-case-report-and-review-of-literature
#4
Kairav Shah, Kartikeya Cherabuddi, Stacy G Beal, Gautam Kalyatanda
BACKGROUND: Opportunistic infections with Pneumocystis jiroveci pneumonia (PCP) are common in patients with HIV (human immunodeficiency virus) and are encountered once the CD4 count decreases below 200 cells/mm3. Cytomegalovirus (CMV) tends to cause disease once the CD4 count drops below 50 cells/mm3. CMV pneumonitis is not common in this population. However, detecting its presence in broncho-alveolar lavage (BAL) fluid has been associated with increased morbidity and mortality. The role of antiviral therapy against CMV remains unclear...
2017: IDCases
https://www.readbyqxmd.com/read/28876508/the-effects-of-pirfenidone-in-patients-with-an-acute-exacerbation-of-interstitial-pneumonia
#5
Takuma Matsumura, Kenji Tsushima, Mitsuhiro Abe, Kenichi Suzuki, Kazutaka Yamagishi, Akane Matsumura, Yasunori Ichimura, Jun Ikari, Jiro Terada, Koichiro Tatsumi
Introdcution: The prognosis of patients with an acute exacerbation of interstitial pneumonia (AE-IP) is poor. Pirfenidone (PFD) reduces the disease progression in idiopathic pulmonary fibrosis. OBJECTIVES: The purpose of this study was evaluating whether the administration of PFD improved the outcomes of AE-IP. METHODS: We conducted a retrospective study of 31 patients with AE-IP who did not recover between 7 and 14 days after an initial treatment. Fourteen patients received PFD within 2 weeks (PFD group) of the AE, while 17 patients were treated without PFD (Non-PFD group)...
September 6, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28869233/meropenem-a-possible-new-culprit-in-eosinophilic-lung-diseases
#6
Nathalie Abi Hatem, Sabrina Campbell, Edmundo Rubio, Anthony Lukas Loschner
Eosinophilic lung diseases are a diverse group of pulmonary disorders with an extensive list of differential diagnoses. Multiple drugs particularly antibiotics can cause pulmonary eosinophilia with variable pulmonary manifestations. Cutaneous drug reactions are common. Diagnosis is usually made on clinical history and blood eosinophilia with an accumulation of eosinophils in alveolar spaces on histologic analysis. Imaging findings are nonspecific. Stopping the offending agent is often enough while a short course of corticosteroids can hasten recovery...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28867435/inhaled-corticosteroids-and-pneumonia-risk-revised-knowledge
#7
EDITORIAL
Bo Lundbäck, Helena Backman, Johann Christian Virchow
No abstract text is available yet for this article.
August 24, 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28861334/severe-pneumocystis-jiroveci-pneumonia-in-a-patient-on-temozolomide-therapy-a-case-report-and-review-of-literature
#8
Babar Ahmad Khan, Sania Khan, Benjamin White, Ambika Eranki
A 66 year old man was diagnosed with CNS diffuse large B-cell lymphoma, and underwent treatment with Temozolomide, Dexamethasone, Rituximab, and radiation therapy, and prolonged steroid taper with Dexamethasone. Approximately one month after this, he presented with severe acute hypoxemic respiratory failure, and was admitted to the Medical Intensive Care Unit. Imaging showed diffuse ground glass opacities. Patient underwent diagnostic bronchoalveolar lavage which was positive for Pneumocystis jiroveci. He did not respond well to appropriate therapy and was transitioned to comfort care per his family's wishes, and expired...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28860788/impact-of-immunosuppressant-therapy-on-new-onset-diabetes-in-liver-transplant-recipients
#9
Fu-Chao Liu, Huan-Tang Lin, Jr-Rung Lin, Huang-Ping Yu
This nationwide, population-based study aimed to clarify the effects of immunosuppressive regimens on new-onset diabetes after liver transplantation (NODALT). The National Health Insurance database of Taiwan was explored for patients who received liver transplantation without pre-transplant diabetes from 1998 to 2012. Information regarding clinical conditions and immunosuppressant utilization among these patients was analyzed statistically. Of the 2,140 patients included in our study, 189 (8.8%) developed NODALT...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28860742/severe-exacerbation-and-pneumonia-in-copd-patients-treated-with-fixed-combinations-of-inhaled-corticosteroid-and-long-acting-beta2-agonist
#10
Hsi-Hsing Yang, Chih-Cheng Lai, Ya-Hui Wang, Wei-Chih Yang, Cheng-Yi Wang, Hao-Chien Wang, Likwang Chen, Chong-Jen Yu
BACKGROUND: It remains unclear whether severe exacerbation and pneumonia of COPD differs between patients treated with budesonide/formoterol and those treated with fluticasone/salmeterol. Therefore, we conducted a comparative study of those who used budesonide/formoterol and those treated with fluticasone/salmeterol for COPD. METHODS: Subjects in this population-based cohort study comprised patients with COPD who were treated with a fixed combination of budesonide/formoterol or fluticasone/salmeterol...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28851379/prognosis-and-treatment-of-folfox-therapy-related-interstitial-pneumonia-a-plea-for-multimodal-immune-modulating-therapy-in-the-respiratory-insufficient-patient
#11
Annick De Weerdt, Amélie Dendooven, Annemie Snoeckx, Jan Pen, Martin Lammens, Philippe G Jorens
BACKGROUND: The FOLFOX regimen, i.e., folinic acid (FOL), fluorouracil (F) and oxaliplatin (OX), is a drug cocktail that is used to treat gastric and colorectal cancers. Despite the concomitant improvements in response rate, duration of response and patient survival, reports of serious toxic pulmonary side effects have progressively emerged. CASE PRESENTATION: We describe a patient who was treated with FOLFOX as an adjuvant to a rectosigmoidal resection of a rectosigmoidal carcinoma and who developed respiratory insufficiency requiring mechanical ventilation...
August 29, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28835429/a-rare-case-of-pulmonary-toxoplasmosis-in-a-patient-with-undifferentiated-inflammatory-arthritis-on-chronic-methotrexate-and-corticosteroid-therapy
#12
Abdullateef Abdulkareem, Ryan Steven D'Souza, Nitin Patel, Anthony A Donato
Pulmonary toxoplasmosis is a serious pulmonary condition caused by the protozoan Toxoplasma gondii It typically affects immunocompromised patients presenting acutely with cough, fever, myalgias, arthralgias and lymphadenopathy, and chronically with persistent cough and dyspnoea. Because of its protean features, it can mimic many more common lung conditions in the immunocompromised patient, including atypical pneumonia, Pneumocystis pneumonia and interstitial lung disease. In this article, we present the case of a 55-year-old woman who presented to our hospital with persistent dyspnoea and cough, initially suspected to have an arthritis-related interstitial lung disease...
August 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28831373/chronic-eosinophilic-pneumonia-after-radiation-therapy-for-squamous-cell-lung-cancer
#13
Hiromasa Nakayasu, Toshihiro Shirai, Yuko Tanaka, Mika Saigusa
Reports of chronic eosinophilic pneumonia (CEP) after radiation therapy are limited to breast cancer. We herein describe a case of CEP after radiation therapy for lung cancer. The patient was a 65-year-old man who had asymptomatic peripheral blood eosinophilia but no history of asthma or allergy. One month after completion of radiation therapy, chest CT scan revealed infiltrates inside the irradiated area, leading to the diagnosis of radiation pneumonitis. His condition improved after receiving corticosteroids...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28814851/effect-of-allergic-phenotype-on-treatment-response-to-inhaled-bronchodilators-with-or-without-inhaled-corticosteroids-in-patients-with-copd
#14
Shih-Lung Cheng, Hsu Hui Wang, Ching-Hsiung Lin
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder encompassing different phenotypes with different responses to treatment. The present 1-year, two-center hospital-based study investigated whether the plasma immunoglobulin E (IgE) level and/or eosinophil cell count could be used as biomarkers to stratify patients with COPD according to predicted responses to inhaled corticosteroids (ICS)-based therapy. METHODS: A hospital-data based cohort study of COPD patients treated at two territory hospital centers was conducted for 1 year...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28810835/secondary-organizing-pneumonia-following-viral-pneumonia-caused-by-severe-influenza-b-a-case-report-and-literature-reviews
#15
Nobuhiro Asai, Toyoharu Yokoi, Naoya Nishiyama, Yusuke Koizumi, Daisuke Sakanashi, Hideo Kato, Mao Hagihara, Hiroyuki Suematsu, Yuka Yamagishi, Hiroshige Mikamo
BACKGROUND: Some reported that organizing pneumonia (OP) may occur after influenza A infections including swine-origin influenza A (H1N1). However, OP associated with influenza B infection has never been reported. We report the first case of secondary OP associated with viral pneumonia caused by influenza B. CASE PRESENTATION: A 23-year old woman was diagnosed as viral pneumonia caused by type B influenza. Despite of antiviral therapy, abnormal chest shadows were not improved...
August 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28803456/evaluation-of-prenatal-corticosteroid-use-in-spontaneous-preterm-labor-in-the-brazilian-multicenter-study-on-preterm-birth-emip
#16
Tabata Z Dias, Renato Passini, Ricardo P Tedesco, Giuliane J Lajos, Patricia M Rehder, Marcelo L Nomura, Maria L Costa, Paulo F Oliveira, Maria H Sousa, Jose G Cecatti
OBJECTIVE: To evaluate prenatal corticosteroid use in women experiencing spontaneous preterm labor and preterm delivery. METHODS: The present cross-sectional multicenter study analyzed interview data from patients attending 20 hospitals in Brazil owing to preterm delivery between April 1, 2011, and September 30, 2012. Patients were stratified based on preterm labor occurring before 34 weeks or at 34-36(+6) weeks of pregnancy, and the frequency of prenatal corticosteroid use at admission was compared...
August 13, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28801320/in-stable-copd-long-acting-muscarinic-antagonist-plus-long-acting-beta-agonists-resulted-in-less-exacerbations-pneumonia-and-larger-improvement-in-fev-1-than-long-acting-beta-agonists-plus-inhaled-corticosteroids
#17
https://www.readbyqxmd.com/read/28794031/combinatorial-effects-of-the-glucocorticoid-receptor-and-kr%C3%A3-ppel-like-transcription-factor-15-on-bovine-herpesvirus-1-transcription-and-productive-infection
#18
Fouad S El-Mayet, Laximan Sawant, Prasanth Thunuguntla, Clinton Jones
Bovine herpesvirus 1 (BoHV-1), an important bovine pathogen, establishes life-long latency in sensory neurons. Latently infected calves consistently reactivate from latency following a single intravenous injection of the synthetic corticosteroid dexamethasone. The immediate early transcription unit 1 (IEtu1) promoter, which drives bICP0 and bICP4 expression, is stimulated by dexamethasone because it contains two glucocorticoid receptor (GR) response elements (GREs). Several Krüppel-like transcription factors (KLF), including KLF15, are induced during reactivation from latency and they stimulate certain viral promoters and productive infection...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28791279/pneumocystis-jirovecii-pneumonia-in-pediatric-inflammatory-bowel-disease-a-case-report-and-literature-review
#19
Sally J Lawrence, Manish Sadarangani, Kevan Jacobson
Immunosuppressive therapy is a known risk factor for opportunistic infections. We report the first case of severe Pneumocystis jirovecii infection requiring intensive care in a pediatric patient with inflammatory bowel disease (IBD). The literature was reviewed and there were 92 reported cases of Pneumocystis pneumonia (PCP) in patients with IBD. Most sources were case reports and there was likely reporting bias toward patients receiving immunomodulators, anti-tumor necrosis factor (anti-TNF) therapy, and those who died...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28757436/etanercept-and-corticosteroid-therapy-for-the-treatment-of-late-onset-idiopathic-pneumonia-syndrome
#20
Jonathan Thompson, Ziyan Yin, Anita D'Souza, Timothy Fenske, Mehdi Hamadani, Parameswaran Hari, J Douglas Rizzo, Marcelo Pasquini, Wael Saber, Nirav Shah, Bronwen E Shaw, Kaushik Shahir, Anjishnu Banerjee, William R Drobyski
Idiopathic pneumonia syndrome (IPS) is a complication of allogeneic hematopoietic stem cell transplantation (HSCT) that typically occurs within the first 100 days after transplantation. Tumor necrosis factor α (TNF-α) has been shown to be a key mediator of IPS, and the TNF-α binding protein etanercept appeared to improve IPS outcomes in small retrospective and prospective studies. IPS also has been observed to occur later (>100 days) after HSCT; however, little is known about the disease course and whether a TNF-α-based therapeutic strategy is efficacious in these patients...
July 27, 2017: Biology of Blood and Marrow Transplantation
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