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mometasone furoate nasal

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https://www.readbyqxmd.com/read/29669668/pharmacokinetics-of-intranasal-mometasone-in-the-fixed-dose-combination-gsp301-versus-two-monotherapy-intranasal-mometasone-formulations
#1
Piyush Patel, Anne Marie Salapatek, Ravi S Talluri, Sudeesh K Tantry
BACKGROUND: GSP301 is a fixed-dose combination (FDC) of the antihistamine olopatadine hydrochloride and the corticosteroid mometasone furoate developed as a single nasal spray (NS). OBJECTIVE: To assess the relative bioavailability of mometasone administered as GSP301 FDC versus two mometasone monotherapy NS formulations. METHODS: In this single-dose, open-label, crossover study, healthy adults (age range, 18-65 years) were randomized equally to one of six treatment sequences for three 72-hour treatment periods with GSP301 (olopatadine 665 μg-mometasone 50 μg), the mometasone furoate monotherapy component of GSP301 (MF-sponsor, 50 μg), and U...
May 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29669667/pharmacokinetics-of-intranasal-olopatadine-in-the-fixed-dose-combination-gsp301-versus-two-monotherapy-intranasal-olopatadine-formulations
#2
Piyush Patel, Anne Marie Salapatek, Ravi S Talluri, Sudeesh K Tantry
BACKGROUND: GSP301 is a fixed-dose combination of the antihistamine olopatadine hydrochloride and the corticosteroid mometasone furoate developed as a single nasal spray. OBJECTIVE: To assess the relative bioavailability of olopatadine administered as GSP301 versus two olopatadine monotherapy nasal spray formulations. METHODS: In this single-dose, open-label, crossover study, healthy adults (18-65 years old) were equally randomized to one of six treatment sequences for three 48-hour treatment periods with GSP301 (olopatadine 665 μg-mometasone 50 μg), the olopatadine monotherapy component of GSP301 (OLO-sponsor; 665 μg) and U...
May 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29644886/effects-of-a-thermosensitive-in-situ-gel-containing-mometasone-furoate-on-a-rat-allergic-rhinitis-model
#3
Ebru Altuntaş, Gülgün Yener, Remzi Doğan, Fadlullah Aksoy, Mehmet Şerif Aydın, Ersin Karataş
Background Mometasone furoate, one of the second generation intranasal corticosteroids, is currently used in suspension form due to its poor solubility. However, this is not favorable for nasal application because of the rapid elimination of the instilled drug from the nasal cavity by mucociliary clearance and delayed onset of action due to the slow dissolution of drug in suspension. Objective The aim of this study was to determine the antiallergic effects of mucoadhesive thermosensitive in situ gel containing mometasone furoate that we developed previously to prolong the contact between the drug and nasal mucosa and to prevent drainage of the formulation in an ovalbumin-induced rat model of allergic rhinitis...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29553112/-evaluations-of-sensory-attribute-of-intranasal-corticosteroid-sprays-in-healthy-volunteers
#4
Tetsuo Watanabe, Masashi Suzuki
BACKGROUND: Intranasal corticosteroid sprays (INCSs) have not been a mainstay of the treatment for nasal allergies. We evaluated the sensory effects of INCSs since they might affect compliance to treatment. METHODS: The study population included 45 healthy volunteers. The subjects were randomized 1 : 1 to receive fluticasone furoate (FF) followed by mometasone furoate (MF) or MF followed by FF. There was a 30-minutes waiting period between the administration of each drug...
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29518474/anti-allergy-activities-of-kuji-amber-extract-and-kujigamberol
#5
Miku Maruyama, Miki Kobayashi, Takeshi Uchida, Eisaku Shimizu, Hironori Higashio, Misa Ohno, Shota Uesugi, Ken-Ichi Kimura
Amber is fossilized tree resin and several biologically active compounds were isolated from ambers using the growth-restoring activity of the mutant yeast [Saccharomyces cerevisiae (zds1∆ erg3∆ pdr1∆ pdr3∆)] involving Ca2+ -signal transduction. The aim of this study is to investigate the anti-allergic effect of both the methanol extract of Kuji amber (MEKA) and its main biologically active constituent, kujigamberol (15,20-dinor-5,7,9-labdatrien-18-ol) having activity against the mutant yeast. Both MEKA and kujigamberol inhibited the degranulation of RBL-2H3 cells by stimulation of thapsigargin (Tg) (IC50  = 15...
March 5, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29493722/the-effects-of-mometasone-furoate-and-strontium-chloride-in-a-rat-model-of-allergic-rhinitis
#6
Emine Elif Altuntaş, Ömer Tamer Doğan, Bülent Saraç, Nergiz Hacer Turgut, Kasım Durmuş, Melih Akyol
Neurogenic inflammation plays a role in the pathophysiology of allergic rhinitis. Highly effective in reducing the sensory irritation caused by some substances, strontium salts directly affect C-type nerve fibers. The aim of this study was to compare the efficacy of mometasone furoate and strontium chloride on early-phase symptoms in a rat model of allergic rhinitis. Wistar albino rats (n = 24) were randomly divided into three groups: the mometasone group, receiving 1 μg mometasone furoate (2 µl/site); the strontium 3% group, receiving 3% strontium chloride (2 μl/site); and the strontium 5% group, receiving 5% strontium chloride (2 μl/site)...
January 2018: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29350840/a-phase-3-trial-of-mometasone-furoate-sinus-implants-for-chronic-sinusitis-with-recurrent-nasal-polyps
#7
Robert C Kern, J Pablo Stolovitzky, Stacey L Silvers, Ameet Singh, Jivianne T Lee, David M Yen, Alfred M C Iloreta, Francis P J Langford, Boris Karanfilov, Keith E Matheny, James W Stambaugh, Anna K Gawlicka
BACKGROUND: Topical intranasal corticosteroid sprays (INCSs) are standard treatment for nasal polyps (NPs), but their efficacy is reduced by poor patient compliance and impaired access of drug to the sinus mucosa. A corticosteroid-eluting sinus implant was designed to address these limitations in patients with recurrent polyposis after sinus surgery by delivering 1350 μg of mometasone furoate (MF) directly to the ethmoid sinus mucosa over approximately 90 days. METHODS: A randomized, sham-controlled, double-blind trial was undertaken in 300 adults with refractory chronic rhinosinusitis with NPs (CRSwNP), who were candidates for repeat surgery...
April 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29168468/strontium-chloride-hexahydrate-as-a-candidate-molecule-for-long-term-treatment-of-allergic-rhinitis
#8
Emine Elif Altuntas, Nergiz Hacer Turgut, Kasım Durmuş, Ömer Tamer Doǧan, Melih Akyol
BACKGROUND & OBJECTIVES: Neurogenic inflammation plays a role in the pathophysiology of allergic rhinitis (AR). Strontium salts are highly effective in reducing the sensory irritation. This study was aimed to investigate the efficacy of strontium chloride (SC) on AR symptoms based on the duration of SC use before the symptoms begin. METHODS: Wistar albino rats (n=18) were randomly divided into three groups: Group 1, received 1μg mometasone furoate (MF); Group 2, three per cent SC; and Group 3 received five per cent SC (2 μl/site)...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29035825/effect-of-a-combination-of-mometasone-furoate-levofloxacin-and-retinyl-palmitate-with-an-in-situ-gel-forming-nasal-delivery-system-on-nasal-mucosa-damage-repair-in-an-experimental-rabbit-model
#9
Fadlullah Aksoy, Remzi Dogan, Orhan Ozturan, Ebru Altuntas, Fatma Gülgün Yener, Gulactı Topcu, Beril Guler
BACKGROUND: In this study a combination of Mometasone Furoate (MF)+Levofloxacin hemihydrate (LH)+Retinyl palmitate (RP) with an in situ gel-forming delivery system was evaluated at different stages of nasal mucosal damage repair in a rabbit maxillary sinus model. METHODS: In this study, 28 rabbits were included and assigned randomly to four groups. In all rabbits, a standard ostium was opened in the medial wall of the maxillary sinus by using a drill. Two different subsequently prepared gels with an in situ gel-forming delivery system were used...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28814353/pre-and-postoperative-blood-neutrophil-to-lymphocyte-and-eosinophil-to-lymphocyte-ratios-in-patients-with-sinonasal-polyps-a-preliminary-investigation
#10
Giuseppe Brescia, Umberto Barion, Claudia Zanotti, Daniela Parrino, Gino Marioni
BACKGROUND: Identifying specific endotypes within the broad picture of chronic rhinosinusitis with nasal polyps (CRSwNP), by using biomarkers for instance, remains a challenge. The prognostic role of the neutrophil-to-lymphocyte ratio (NLR) and the eosinophil-to-lymphocyte ratio (ELR) as potential markers of inflammation has already been discussed. OBJECTIVE: The aim of the present study was to compare NLR and ELR before and after endoscopic sinus surgery (ESS) and nasal mometasone furoate for CRSwNP by stratifying patients by their clinical and histologic features...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28802371/how-can-we-improve-medical-adherence-to-intranasal-corticosteroids-in-children
#11
Emre Ocak, Deniz Kocaoz, Baran Acar
OBJECTIVE: To evaluate the factors which may be related to nonadherence to intranasal corticosteroids (ICS) in the treatment of allergic rhinitis (AR) in children. METHODS: A prospective study was conducted on children with AR diagnosis in a tertiary referral hospital. All participants were provided with mometasone furoate nasal sprays for 30 days after the diagnosis. Caregivers were called back when the therapy was over and completed a questionnaire about the factors that may influence the adherence to the treatment...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28677353/individualized-treatment-of-allergic-rhinitis-according-to-nasal-cytology
#12
Jianjun Chen, Yue Zhou, Li Zhang, Yanjun Wang, Amber N Pepper, Seong H Cho, Weijia Kong
PURPOSE: Nasal cytology is important in the diagnosis and treatment of nasal inflammatory diseases. Treatment of allergic rhinitis (AR) according to nasal cytology has not been fully studied. We plan to explore the individualized treatment of AR according to nasal cytology. METHODS: Nasal cytology from 468 AR patients was examined for inflammatory cell quantity (grade 0-5) and the percentage of neutrophils and eosinophils. Results were subdivided into the following categories: AR(Eos), eosinophil ≥50% of the whole inflammatory cells; AR(Neu), neutrophils ≥90%; AR(Eos/Neu), 10%≤ eosinophil <50%; AR(Low), grade 0/1 inflammatory cell quantity...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28514369/-the-role-of-topical-glucocorticoids-in-the-treatment-of-rhinosinusitis
#13
E G Shakhova
The guidelines of the European position paper on rhinosinusitis and nasal polyps (EPOS, 2012) ascribe the highest strength and the most comprehensive evidence-based significance to the application of intranasal glucocorticosteroids (inGCS) as the first-line therapy for the patients presenting with acute and polypous rhinosinusitis; moreover they are recommended as the medications of choice for the treatment of chronic rhinosinusitis in the absence of polyps. The author presents the data concerning the mechanism of action, clinical effectiveness, and safety of inGCS used for the treatment of acute, recurrent, and chronic rhinosinusitis...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28514368/-the-use-of-modern-topical-medications-for-the-stepwise-treatment-of-allergic-rhinitis-the-effectiveness-and-prospects-for-the-further-extension-of-their-application
#14
REVIEW
E V Nosulya, I A Kim
The objective of the present work was to summarize the results of clinical studies designed to evaluate the effectiveness of 'Momate Rhino Advance' in the form of the nasal spray (based on the fixed combination of mometasone furoate and azelastine) that finds an increasingly wide application for the treatment of allergic rhinitis. The available data give evidence that this medication can be prescribed to the patients presenting with the severe and moderate form of allergic rhinitis. The treatment should be started with the use of the combined preparation and continued, after the adequate control of the clinical symptoms of allergic rhinitis is achieved, using 'Momate Rhino' during the next 2-4 weeks for the reliable management of the disease...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28493194/effectiveness-of-quercetin-in-an-experimental-rat-model-of-allergic-rhinitis
#15
Mustafa Sagit, Halil Polat, Seren Gulsen Gurgen, Elife Berk, Sabri Guler, Mehmet Yasar
We aimed to investigate whether quercetin had a therapeutic effect in an experimental rat model of allergic rhinitis. The study was conducted with 35 rats, which were randomly assigned into 4 groups: group 1 (n = 5), sham group; group 2 (quercetin group, n = 10) received 80 mg/kg day quercetin; group 3 (steroid group, n = 10) received steroid (mometasone furoate); and group 4 (control group, n = 10), received ovalbumin alone. Rats were sensitized by administration of ovalbumin on alternate days over 14 days via an intraperitoneal route...
August 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28489737/clinical-effect-of-montelukast-sodium-combined-with-inhaled-corticosteroids-in-the-treatment-of-osas-children
#16
Da-Zhi Yang, Jia Liang, Feng Zhang, Hong-Bing Yao, Yan Shu
This study was designed to investigate the clinical effect of montelukast sodium combined with inhaled corticosteroids in the treatment of children with obstructive sleep apnea syndrome (OSAS).One hundred ninety-five children were enrolled and divided into 3 groups: groups A, B, and C; the group A (oral use of montelukast sodium), group B (nasal spray of mometasone furoate), and group C (oral use of montelukast sodium + nasal spray of mometasone furoate). Telephone questionnaire surveys were carried out. Polysomnography monitoring was performed and lateral x-ray radiographs of the cervical spine were taken before treatment and at 12 weeks after treatment...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28281209/formulation-and-evaluation-of-thermoreversible-in-situ-nasal-gels-containing-mometasone-furoate-for-allergic-rhinitis
#17
Ebru Altuntaş, Gülgün Yener
The purpose of the present work was to develop a mucoadhesive thermoreversible nasal gel with a tailored gelling temperature to provide the prolonged contact between mometasone furoate and the nasal mucosa and in order to prevent drainage of the formulation. For this purpose, in situ gel containing a thermogelling polymer poloxamer 407 (Pluronic® F-127) and a mucoadhesive polymer Carbopol® 974P NF was prepared. In this content, formulations were designed to have gelation temperature below 34°C to obtain gelation at intranasal cavity...
October 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28109729/comparison-of-the-effects-of-nasal-steroids-and-montelukast-on-olfactory-functions-in-patients-with-allergic-rhinitis
#18
A Dalgic, M E Dinc, S Ulusoy, D Dizdar, A Is, M Topak
OBJECTIVE: Olfactory dysfunction is one of the comorbidities associated with allergic rhinitis (AR) and AR is one of the common causes of olfactory problems. We aimed to evaluate by the Sniffin' Sticks test the effects on olfactory functions of nasal steroids and leukotriene antagonists used for allergic rhinitis. METHODS: Thirty patients with seasonal rhinitis were included in this study. Patients were randomly divided into three groups of 10 patients; group 1 received montelukast sodium and mometasone furoate (MF) therapy, group 2 received only montelukast, and group 3 only MF...
September 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28098165/combination-of-mometasone-furoate-and-oxymetazoline-for-the-treatment-of-adenoid-hypertrophy-concomitant-with-allergic-rhinitis-a-randomized-controlled-trial
#19
Wenlong Liu, Lifeng Zhou, Qingxiang Zeng, Renzhong Luo
In the clinic, approximately 30% of children with adenoid hypertrophy (AH) concomitant with allergic rhinitis (AR) report poor responses to intranasal steroids. To determine whether the combination of mometasone furoate (MF) and oxymetazoline (OXY) is more effective than either agent alone, we performed a two-stage, parallel, randomized, double-blind, double-dummy, clinical trial with 240 AH children with concomitant perennial AR. During the first stage, all children were randomly assigned to the MF or control group for six weeks of treatment...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27698668/radioactive-merano-spa-treatment-for-allergic-rhinitis-therapy
#20
Desiderio Passali, Giacomo Gabelli, Giulio Cesare Passali, Roberto Magnato, Stefan Platzgummer, Lorenzo Salerni, Salvatore Lo Cunsolo, Alexandra Joos, Luisa Maria Bellussi
Allergic rhinitis is a common nasal disorder with a high impact on quality of life, high social costs in therapies, and a natural development towards asthma. Pharmacological therapy is based on several genres of medications, of which intranasal corticosteroids are currently the most widespread. Thermal water treatment has traditionally been used as adjunctive treatment for chronic rhinitis and sinusitis. The present study was carried out to assess the clinical efficacy of nasal inhalation of radioactive oligomineral water vapours from the Merano hot spring and to compare it with the clinical efficacy of mometasone furoate nasal spray...
2016: International Journal of Otolaryngology
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