keyword
MENU ▼
Read by QxMD icon Read
search

Acyclovir

keyword
https://www.readbyqxmd.com/read/29453157/-the-spanish-society-of-paediatric-infectious-diseases-guidelines-on-the-prevention-diagnosis-and-treatment-of-neonatal-herpes-simplex-infections
#1
(no author information available yet)
Neonatal herpes simplex virus infections are rare, but are associated with significant morbidity and mortality. Most newborns acquire herpes simplex virus infection in the peripartum period. For peripartum transmission to occur, women must be shedding the virus in their genital tracts symptomatically or asymptomatically around the time of delivery. There are evidence-based interventions in pregnancy to prevent the transmission to the newborn. Caesarean section should be performed in the presence of herpetic lesions, and antiviral prophylaxis in the last weeks of pregnancy is recommended to suppress genital tract herpes simplex virus at the time of delivery...
February 13, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29451274/helicase-primase-inhibitor-amenamevir-for-herpesvirus-infection-towards-practical-application-for-treating-herpes-zoster
#2
K Shiraki
Valacyclovir and famciclovir enabled successful systemic therapy for treating herpes simplex virus (HSV) and varicella zoster virus (VZV) infection by their phosphorylation with viral thymidine kinase. Helicase-primase inhibitors (HPIs) inhibit the progression of the replication fork, an initial step in DNA synthesis to separate the double strand into two single strands. The HPIs amenamevir and pritelivir have a novel mechanism of action, once-daily administration with nonrenal excretory characteristics, and clinical efficacy for genital herpes...
November 2017: Drugs of Today
https://www.readbyqxmd.com/read/29446921/modeling-of-pharmaceutical-biotransformation-by-enriched-nitrifying-culture-under-different-metabolic-conditions
#3
Yifeng Xu, Xueming Chen, Zhiguo Yuan, Bing-Jie Ni
Pharmaceutical removal could be significantly enhanced through cometabolism during nitrification processes. So far pharmaceutical biotransformation models have not considered the formation of transformation products associated with the metabolic type of microorganisms. Here we reported a comprehensive model to describe and evaluate the biodegradation of pharmaceuticals and the formation of their biotransformation products by enriched nitrifying cultures. The biotransformation of parent compounds was linked to the microbial processes via cometabolism induced by ammonium oxidizing bacteria (AOB) growth, metabolism by AOB, cometabolism by heterotrophs (HET) growth and metabolism by HET in the model framework...
February 15, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29444978/an-off-target-effect-of-bx795-blocks-herpes-simplex-virus-type-1-infection-of-the-eye
#4
Dinesh Jaishankar, Abraam M Yakoub, Tejabhiram Yadavalli, Alex Agelidis, Neel Thakkar, Satvik Hadigal, Joshua Ames, Deepak Shukla
Herpes simplex virus type 1 (HSV-1) causes recurrent mucocutaneous lesions in the eye that may advance to corneal blindness. Nucleoside analogs exemplified by acyclovir (ACV) form the primary class of antiherpetic drugs, but this class suffers limitations due to the emergence of viral resistance and other side effects. While studying the molecular basis of ocular HSV-1 infection, we observed that BX795, a commonly used inhibitor of TANK-binding kinase 1 (TBK1), strongly suppressed infection by multiple strains of HSV-1 in transformed and primary human cells, cultured human and animal corneas, and a murine model of ocular infection...
February 14, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29437933/well-appearing-newborn-with-a-vesiculobullous-rash-at-birth
#5
Sarah E Stewart, Jody L Lin, Jennifer L Everhart, Trung H Pham, Ann L Marqueling, Kerri E Rieger, Sarah L Hilgenberg
A term, appropriate-for-gestational-age, male infant born via normal spontaneous vaginal delivery presented at birth with a full-body erythematous, vesiculobullous rash. He was well-appearing with normal vital signs and hypoglycemia that quickly resolved. His father had a history of herpes labialis. His mother had an episode of herpes zoster during pregnancy and a prolonged rupture of membranes that was adequately treated. The patient underwent a sepsis workup, including 2 attempted but unsuccessful lumbar punctures, and was started on broad-spectrum antibiotics and acyclovir, given concerns about bacterial or viral infection...
February 6, 2018: Pediatrics
https://www.readbyqxmd.com/read/29433118/-trigeminal-herpes-zoster-presenting-with-high-intensity-signals-for-the-spinal-trigeminal-nucleus-and-tract-on-diffusion-weighted-image-a-case-report-of-stroke-mimic
#6
Takahiro Himeno, Shinichi Takeshima, Satoshi Kubo, Naoyuki Hara, Akio Tanaka, Masaru Kuriyama
A 50-year-old woman was admitted to our hospital with dysesthesia on the right upper portion of her face and a headache. Diffusion-weighted brain magnetic resonance imaging (MRI) revealed high-intensity signals in the dorsolateral portion of the medulla oblongata. She was diagnosed with lateral medullary infarction and was intravenously treated with sodium ozagrel. On the second day of hospitalization, she had nausea and vomiting and showed nystagmus to all directions, suggesting damage to the vestibular nucleus...
February 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29431387/herpes-zoster-and-postherpetic-neuralgia-prevention-and-management
#7
Aaron Saguil, Shawn Kane, Michael Mercado, Rebecca Lauters
Herpes zoster, or shingles, is caused by reactivation of varicella zoster virus, which causes chickenpox. There are an estimated 1 million cases in the Unites States annually, with an individual lifetime risk of 30%. Patients with conditions that decrease cell-mediated immunity are 20 to 100 times more likely to develop herpes zoster. Patients may present with malaise, headache, low-grade fever, and abnormal skin sensations for two to three days before the classic maculopapular rash appears. The rash is usually unilateral, confined to a single dermatome, and typically progresses to clear vesicles that become cloudy and crust over in seven to 10 days...
November 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29427804/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biological-therapies-an-infectious-diseases-perspective-immune-checkpoint-inhibitors-cell-adhesion-inhibitors-sphingosine-1-phosphate-receptor-modulators
#8
REVIEW
Gil Redelman-Sidi, Olivier Michielin, Carlos Cervera, Camillo Ribi, José María Aguado, Mario Fernández-Ruiz, Oriol Manuel
BACKGROUND: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. AIMS: To review, from an Infectious Diseases perspective, the safety profile of immune checkpoint inhibitors, LFA-3-targeted agents, cell adhesion inhibitors, sphingosine-1-phosphate receptor modulators and proteasome inhibitors and to suggest preventive recommendations. SOURCES: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family...
February 7, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29426966/multi-viral-canaliculitis-case-report-and-review-of-literature
#9
Mohammad Javed Ali, Joveeta Joseph, Shweta Gupta, Sai Jeevana Madhuri Guda
AIM: To report an atypical case of multiple viruses causing canaliculitis. METHODS: Case report of a young female presenting with atypical course of refractory unilateral canaliculitis with complete mid-bicanalicular obstructions. Canalicular scrapings were subjected to immunofluorescence techniques and polymerase chain reactions to identify the viruses. RESULTS: Investigations revealed a canaliculitis of multi-viral etiology; herpes simplex virus and varicella zoster virus...
February 9, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29422758/localized-trichiasis-causing-focal-full-thickness-corneal-edema-endothelial-cell-loss-and-corneal-scarring-requiring-penetrating-keratoplasty
#10
Tiffany Sara Liu, Seth Meskin
The purpose of the study was to report a case of focal trichiasis causing full-thickness corneal edema, scarring, and endothelial cell loss requiring penetrating keratoplasty (PK). A 66-year-old male was referred for trichiasis of the right upper eyelid corresponding to an area of full-thickness corneal edema. No keratic precipitates or guttata was noted. Specular microscopy showed diffuse endothelial cell loss. He was treated with topical steroids and acyclovir with epilation of lashes. Anterior chamber paracentesis was negative for varicella-zoster virus, cytomegalovirus, and herpes simplex virus...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29414753/modeling-photodegradation-kinetics-of-organic-micropollutants-in-water-bodies-a-case-of-the-yellow-river-estuary
#11
Chengzhi Zhou, Jingwen Chen, Huaijun Xie, Ya-Nan Zhang, Yingjie Li, Yan Wang, Qing Xie, Siyu Zhang
Predicting photodegradation rate constants (k) of pollutants in water bodies is important for assessing their persistence and fate. This prediction used to be based on the k values determined under laboratory conditions that seldom consider underwater downward sunlight attenuation in the field. We studied a procedure to predict k taking the Yellow River estuary and two model chemicals (sulfamethoxazole and acyclovir) as a case. Models were developed for predicting underwater sunlight intensities from optically-active substances...
January 31, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29411162/ensuring-safe-drug-administration-to-pediatric-patients-with-renal-dysfunction-a-multicenter-study
#12
Ryoko Harada, Kenji Ishikura, Shunsuke Shinozuka, Naoaki Mikami, Riku Hamada, Hiroshi Hataya, Yoshihiko Morikawa, Tae Omori, Hirotaka Takahashi, Yuko Hamasaki, Tetsuji Kaneko, Kazumoto Iijima, Masataka Honda
BACKGROUND: In pediatric patients, due to variations in baseline serum creatinine (Cr) reference values, renal dysfunctions sometimes go unnoticed. In addition, renally excreted drugs need dose adjustment while nephrotoxic drugs should be avoided altogether in patients with impaired renal function. However, most physicians are apparently unaware of these facts and may administer these drugs to vulnerable patients. METHODS: We administered a questionnaire to all physicians and pharmacists specializing in pediatric medical care at six Tokyo metropolitan government-run hospitals in Japan...
February 6, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29408766/sunct-like-syndrome-preceding-acute-ophthalmic-distribution-zoster-a-case-report-and-review-of-the-literature
#13
Joerg Philipps, Adonis Bytyqi, Blerta Salihaj, Peter Dieter Schellinger
BACKGROUND: SUNCT like syndrome has been observed as a post zoster condition, as a syndrome associated with overt ophthalmic zoster after appearance of herpetic lesions and in varicella zoster virus meningoencephalitis without rash. However, SUNCT like syndrome fully consistent and congruent with the criteria of the ICHD immediately before onset of an ophthalmic-distribution zoster has not been reported. CASE PRESENTATION: We report 73-year-old patient with a SUNCT like syndrome as the first presentation of an acute ophthalmic-distribution zoster...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29402251/varicella-zoster-virus-associated-chorioretinitis-a-case-report
#14
Joo Yeon Kim, Ji Hwan Lee, Christopher Seungkyu Lee, Sung Chul Lee
BACKGROUND: Chorioretinitis is an unusual form of varicella zoster virus (VZV)-associated uveitis, and no report has described VZV-associated chorioretinitis using serial optical coherence tomography (OCT) images obtained during the course of resolution. CASE PRESENTATION: A 61-year-old woman presented with acute, unilateral vision loss in her right eye. Her visual acuity was count fingers in the right eye and 16/20 in the left eye, and she exhibited skin vesicles on her right forehead...
February 5, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29401338/a-tertiary-care-center-s-experience-with-novel-molecular-meningitis-encephalitis-diagnostics-and-implementation-with-antimicrobial-stewardship
#15
David Chang, Jason F Okulicz, Lindsey E Nielsen, Brian K White
Background: Novel molecular techniques, such as the Biofire FilmArray Meningitis/Encephalitis (ME) panel, are increasingly used to improve pathogen detection and time to detection (TtD). The Brooke Army Medical Center antibiotic stewardship program evaluated the impact of the ME panel on empiric antimicrobial usage. Methods: Negative ME panels were analyzed for days of therapy (DOT). The ME panel became available at Brooke Army Medical Center on January 1, 2016 and a retrospective chart review was performed on all hospitalized patients tested by ME panel through April 30, 2016...
January 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29383457/adverse-drug-reactions-triggered-by-the-common-hla-b-57-01-variant-virtual-screening-of-drugbank-using-3d-molecular-docking
#16
George Van Den Driessche, Denis Fourches
BACKGROUND: Idiosyncratic adverse drug reactions have been linked to a drug's ability to bind with a human leukocyte antigen (HLA) protein. However, due to the thousands of HLA variants and limited structural data for drug-HLA complexes, predicting a specific drug-HLA combination represents a significant challenge. Recently, we investigated the binding mode of abacavir with the HLA-B*57:01 variant using molecular docking. Herein, we developed a new ensemble screening workflow involving three X-ray crystal derived docking procedures to screen the DrugBank database and identify potentially HLA-B*57:01 liable drugs...
January 30, 2018: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29380794/real-time-polymerase-chain-reaction-in-acute-retinal-necrosis-following-encephalitis
#17
Vinita Rao, Jyotirmay Biswas, Gopal Lingam
Acute retinal necrosis (ARN) following herpes simplex encephalitis (HSE) in an immunocompetent patient is a rare condition. Quantitative real-time polymerase chain reaction (qPCR) has made it possible to identify and quantify viral genome. We report a case of ARN following HSE managed with the help of qPCR. A 45-year-old man developed ARN following HSE and was treated with intravenous acyclovir and intravitreal foscarnet. The retinitis did not respond initially and the qPCR demonstrated a rise in the number of copies of the HSV-1 viral genome...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29373475/lessons-from-an-outbreak-of-varicella-infection-in-pediatric-hemato-oncology-patients
#18
Michal Manistarski, Dror Levin, Rina Dvir, Sivan Berger-Achituv, Hila Rosenfeld Keidar, Galia Grisaru-Soen, Yehuda Carmeli, Ronit Elhasid
BACKGROUND: Immunocompromized patients exposed to varicella may experience significant morbidity and a 7% mortality rate. Management and outcome of an outbreak of varicella infection among hospitalized pediatric hemato-oncology patients using the guidelines of the American Academy of Pediatrics Committee on Infectious Diseases is presented. PATIENTS AND METHODS: This retrospective study describes an outbreak of varicella infection between February 2011 and June 2011...
January 25, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29365241/pityriasis-rosea-diagnosis-and-treatment
#19
Jose M Villalon-Gomez
Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. The diagnosis is based on clinical and physical examination findings. The herald patch is an erythematous lesion with an elevated border and depressed center. The generalized rash usually presents two weeks after the herald patch. Patients can develop general malaise, fatigue, nausea, headaches, joint pain, enlarged lymph nodes, fever, and sore throat before or during the course of the rash...
January 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29354993/-effect-of-joss-stick-moxibustion-combined-with-pricking-and-cupping-for-acute-herpes-zoster-and-its-mechanism-of-analgesia
#20
Guoping Ye, Meiling Su, Dingyu Zhu, Linyun Zhang, Wang Lin, Li Huang, Mingxia Wu
OBJECTIVE: To observe the effects of conventional western medication and joss stick moxibustion combined with pricking and cupping for herpes zoster in acute stage, and to explore its analgesic mechanism. METHODS: Seventy patients with acute herpes zoster were randomized into an observation group (33 cases after 2 dropping) and a control group (34 cases after 1 dropping). Patients in the observation group were treated with joss stick moxibustion combined with pricking and cupping at local ashi points for 7 times, once every other day...
December 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
keyword
keyword
54187
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"