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https://www.readbyqxmd.com/read/29224352/functional-characterization-of-human-peptide-histidine-transporter-1-in-stably-transfected-mdck-cells
#1
Feifeng Song, Yongjun Hu, Yuqing Wang, David E Smith, Huidi Jiang
The proton-coupled oligopeptide transporter PHT1 (SLC15A4), which facilitates cross-membrane transport of histidine and small peptides from inside the endosomes or lysosomes to cytosol, plays an important role in intracellular peptide homeostasis and innate immune response. However, it remains a challenge to elucidate functional properties of the PHT1 transporter because of its subcellular localization. The purpose of this study was to re-sort hPHT1 protein from the subcellular to outer cell membrane of MDCK cells stably transfected with human PHT1 mutants, and to characterize its functional activity in these cells...
December 11, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29223449/anti-hsv-2-activity-of-peganum-harmala-l-and-isolation-of-the-active-compound
#2
Roudaina Benzekri, Lamjed Bouslama, Adele Papetti, Majdi Hammami, Abderrazak Smaoui, Ferid Limam
Genital herpes is a sexually transmitted disease caused by herpes simplex virus type 2 (HSV-2). Nucleoside analogues such as acyclovir (ACV) are the usual therapy for treating HSV infection. However, the overuse of this drug has led to the emergence of resistant strains. Therefore, the search for new alternative or complementary molecules to overcome this obstacle is needed. In this objective, Peganum harmala was investigated for its HSV-2 activity. The organic extracts of the different plant organs were evaluated for their cytotoxicity on Vero cells by the MTT test and anti HSV-2 activity by plaque reduction assay...
December 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29221652/-acyclovir-resistant-perineal-hsv-infection-revealing-chronic-lymphoid-leukaemia
#3
E A Casassa, P Nicol, R Viraben, C Gaudin, C Bulai Livideanu, C Mengelle, L Lamant, F Fortenfant, C Paul, M P Konstantinou
BACKGROUND: Chronic HSV infection is a cause of chronic perineal ulcerations. We report a case of a chronic and refractory HSV infection revealing chronic lymphoid leukaemia. PATIENTS AND METHODS: An 85-year-old woman with an 8-month history of chronic perineal ulcerations was referred to our dermatology department. She had no previous medical history of herpes infection. Skin biopsies ruled out carcinoma but were consistent with HSV infection. A local swab was positive for HSV2...
December 5, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29212376/a-novel-ion-activated-in-situ-gelling-ophthalmic-delivery-system-based-on-kappa-carrageenan-for-acyclovir
#4
Pingfei Li, Shu Wang, Haoyuan Chen, Shiming Zhang, Shihui Yu, Yuenan Li, Mengsuo Cui, Weisan Pan, Xinggang Yang
The aim of this study was to prepare and evaluate ion-activated in-situ gel ophthalmic drug delivery system based on kappa-carrageenan (KC), using acyclovir as a model drug, hydroxypropyl methylcellulose (HPMC) as the viscosity agent and hydroxypropyl-β-cyclodextrin (HP-β-CD) as the penetration enhancer. The two ternary phase diagrams exhibited the effect of K+ and Ca2+ on the sol-to-gel transition, which turned out that KC was more sensitive to K+. The optimal ophthalmic matrix (prepared from KC and HPMC) was optimized with in-vitro drug release test...
December 6, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29203273/the-traditional-use-of-vachellia-nilotica-for-sexually-transmitted-diseases-is-substantiated-by-the-antiviral-activity-of-its-bark-extract-against-sexually-transmitted-viruses
#5
Manuela Donalisio, Valeria Cagno, Andrea Civra, Davide Gibellini, Giuseppina Musumeci, Massimo Rittà, Manik Ghosh, David Lembo
ETHNOPHARMACOLOGICAL RELEVANCE: Vachellia (Acacia) nilotica and other plants of this genus have been used in traditional medicine of Asian and African countries to treat many disorders, including sexually transmitted diseases, but few studies were performed to validate their anti-microbial and anti-viral activity against sexually transmitted infections. AIM OF THE STUDY: The present study was undertaken to explore whether the ethnomedical use of V.nilotica to treat genital lesions is substantiated by its antiviral activity against the human immunodeficiency virus (HIV), the herpes simplex virus (HSV) and the human papillomavirus (HPV)...
December 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29203034/atypical-presentation-of-herpes-simplex-virus-type-2-infection-refractory-to-treatment-with-acyclovir-in-2-hematologic-patients
#6
D Nieto Rodríguez, E Sendagorta Cudós, J M Rueda Carnero, P Herranz Pinto
Herpesvirus infections are not uncommon in hematologic patients. Our first patient, diagnosed with chronic lymphatic leukemia, presented extensive genital herpes infection refractory to treatment with acyclovir and with a partial response to foscarnet, which had to be withdrawn due to systemic adverse effects. The second patient, diagnosed with follicular Hodgkin lymphoma, presented hypertrophic herpes infection refractory to treatment with acyclovir but that responded to intralesional cidofovir and topical imiquimod...
December 1, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29198381/during-the-emergency-department-evaluation-of-a-well-appearing-neonate-with-fever-should-empiric-acyclovir-be-initiated
#7
Eric Bruno, David Pillus, David Cheng, Gary Vilke, Nicholas Pokrajac
BACKGROUND: Herpes simplex virus (HSV) infection represents significant morbidity and mortality in the neonatal period. Although clear guidelines exist on the evaluation and management of the otherwise well-appearing febrile neonate pertaining to occult serious bacterial infections, there is no standardized approach regarding when to initiate testing and treatment for HSV infection. It is vital we establish a unified guideline based on available clinical research to aid in our decision to evaluate and initiate therapy for this disease...
November 29, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29187701/association-between-concomitant-use-of-acyclovir-or-valacyclovir-with-nsaids-and-an-increased-risk-of-acute-kidney-injury-data-mining-of-fda-adverse-event-reporting-system
#8
Zhihua Yue, Jinhai Shi, Haona Li, Huiyi Li
NSAIDs are likely to be used concomitantly with acyclovir or valacyclovir in clinical practice, but the study on the safety of such combinations was seldom reported. The objective of the study was to investigate reports of acute kidney injury(AKI) events associated with the concomitant use of oral acyclovir or valacyclovir with an NSAID by using the United States Food and Drug Administration(FDA) Adverse Event Reporting System (AERS) database between January 2004 and June 2012. The frequency of AKI events in patients while simultaneously taking either acyclovir or valacyclovir and an NSAID was compared using the Chi-square test...
November 28, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29186456/the-anti-hiv-drug-tenofovir-a-reverse-transcriptase-inhibitor-also-targets-the-herpes-simplex-virus-hsv-dna-polymerase
#9
Graciela Andrei, Sarah Gillemot, Dimitrios Topalis, Robert Snoeck
Background: Genital herpes is an important cofactor for acquisition of HIV infection and effective prophylaxis is a helpful strategy to halt both HIV and HSV transmission. The antiretroviral agent tenofovir, formulated as a vaginal microbicide gel, was shown to reduce the risk of HIV and HSV-2 acquisition. Methods: HSV-1 and HSV-2 mutants were selected for resistance to tenofovir and PMEO-DAPy (an acyclic nucleoside phosphonate with dual anti-HSV and anti-HIV activity) by stepwise dose escalation...
November 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29166922/herpes-simplex-type-1-pneumonitis-and-acute-respiratory-distress-syndrome-in-a-patient-with-chronic-lymphatic-leukemia-a-case-report
#10
Miriam Luginbuehl, Alexander Imhof, Alexander Klarer
BACKGROUND: Pulmonary pathogenicity of herpes simplex virus type 1 in patients in intensive care without classic immunosuppression as well as the necessity of antiviral treatment in the case of herpes simplex virus detection in respiratory specimens in these patients is controversial. We present a case of acute respiratory distress syndrome in a patient with stable chronic lymphatic leukemia not requiring treatment, in whom we diagnosed herpes simplex virus type 1 bronchopneumonitis based on herpes simplex virus type 1 detection in bronchoalveolar lavage fluid and clinical response to antiviral treatment...
November 23, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29159001/a-unique-case-of-acute-cerebral-venous-sinus-thrombosis-secondary-to-primary-varicella-zoster-virus-infection
#11
Syed F Imam, Omair Ul Haq Lodhi, Zainab Fatima, Saneeya Nasim, Waseem T Malik, Muhammad Sabih Saleem
Primary varicella zoster virus (VZV) infection, predominantly in the pediatric population, presents with pyrexia and a classic pruritic vesicular rash. In adults, although less common, it is more severe and linked to more complications. Neurological complications, which account for less than 1% of all VZV complications, include meningitis, encephalitis, arterial vasculopathy, and venous thrombosis. We present a case of a 39-year-old male who developed extensive cerebral venous sinus thrombosis following primary VZV infection...
September 16, 2017: Curēus
https://www.readbyqxmd.com/read/29158737/herpes-simplex-virus-and-human-papillomavirus-coinfections-in-hyperimmunoglobulin-e-syndrome-presenting-as-a-conjunctival-mass-lesion
#12
Mitra Akbari, Ramin Elmi
Hyperimmunoglobulin E syndrome (HIES) or Job's syndrome is a rare immunodeficiency disease with less than 200 cases reported worldwide, among which few cases are reported with lesions due to herpes simplex virus (HSV) or human papillomavirus (HPV). This case study presents a rare case of HIES with coinfection of HSV and HPV. A 12-year-old boy, previously diagnosed with HIES, presented with a large conjunctival mass lesion. The presence of HPV in the lesion was confirmed by biopsy and by using the line-probe assay method to detect the HPV genome...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/29155164/a-new-promising-candidate-to-overcome-drug-resistant-herpes-simplex-virus-infections
#13
Elisabeth Zinser, Adalbert Krawczyk, Petra Mühl-Zürbes, Ulrich Aufderhorst, Lena Stich, Mirko Zaja, Stefan Strobl, Alexander Steinkasserer, Christiane Silke Heilingloh
Infections with Herpes simplex viruses (HSV) belong to the most common human diseases worldwide, resulting in symptoms ranging from painful, but commonly self-limiting lesions of the orofacial or genital tract to severe infections of the eye or life-threatening generalized infections. Frequent HSV-reactivations at the eye may lead to the development of herpetic stromal keratitis, which is one of the major causes of infectious blindness in developed countries. The vast majority of life-threatening generalized infections occur in immunocompromised individuals, such as transplant recipients or patients suffering from advanced human immunodeficiency virus (HIV) infection with concurrent HSV-reactivation...
November 15, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29153295/effect-of-single-intra-cutaneous-injection-for-acute-thoracic-herpes-zoster-and-incidence-of-postherpetic-neuralgia
#14
Ji-Zheng Cui, Jin-Wei Zhang, Fang Yan, Xiao-Na Yang, Xin-Ling Wang, Zhi-Bin Zhao, Xiao-Bao Zhang, Zhu-Sheng Geng
The therapeutic effect of postherpetic neuralgia (PHN) is often disappointing and challenging. The role of intra-cutaneous injection of local anesthetic and steroids in preventing PHN remains unknown. The purpose of this study was to investigate the effect of a single intra-cutaneous injection of ropivacaine plus methylprednisolone on acute thoracic herpes zoster (HZ) pain intensity and duration, eruptive duration, and PHN incidence. A total of 97 patients with acute thoracic HZ diagnosed 1-7 days after the onset of the rash were randomly assigned to receive either 15 mL of 37...
November 15, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29137671/herpes-simplex-virus-1-entrapped-in-candida-albicans-biofilm-displays-decreased-sensitivity-to-antivirals-and-uva1-laser-treatment
#15
Cristian Ascione, Arianna Sala, Elham Mazaheri-Tehrani, Simona Paulone, Beniamino Palmieri, Elisabetta Blasi, Claudio Cermelli
BACKGROUND: Recently, we published data suggesting a mutualistic relationship between HSV-1 and Candida. albicans; in particular: (a) HSV-1 infected macrophages are inhibited in their anti-Candida effector function and (b) Candida biofilm protects HSV-1 from inactivation. The present in vitro study is aimed at testing the effects of Candida biofilm on HSV-1 sensitivity to pharmacological and physical stress, such as antiviral drugs (acyclovir and foscarnet) and laser UVA1 irradiation...
November 14, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29132770/-management-of-pregnant-women-with-recurrent-herpes-guidelines-for-clinical-practice-from-the-french-college-of-gynecologists-obstetricians-cngof
#16
O Anselem
OBJECTIVE: To provide guidelines for the management of woman with genital herpes during pregnancy or labor and with known history of genital herpes. METHODS: MedLine and Cochrane Library databases search and review of the main foreign guidelines. RESULTS: Genital herpes ulceration during pregnancy in a woman with history of genital herpes correspond to a recurrence. In this situation, there is no need for virologic confirmation (Grade B). In case of recurrent herpes during pregnancy, antiviral therapy with acyclovir or valacyclovir can be administered but provide low efficiency on duration and severity of symptoms (Grade C)...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29132768/pr%C3%A3-vention-et-prise-en-charge-de-l%C3%A2-infection-herp%C3%A3-tique-au-cours-de-la-grossesse-et-de-l%C3%A2-accouchement%C3%A2-recommandations-pour-la-pratique-clinique-%C3%A2-%C3%A2-texte-des-recommandations-texte-court
#17
M-V Sénat, O Anselem, O Picone, L Renesme, N Sananès, C Vauloup-Fellous, Y Sellier, J-P Laplace, L Sentilhes
OBJECTIVE: Identify measures to diagnose, prevent and treat genital herpes infection during pregnancy and childbirth and neonatal infection. METHODS: Bibliographic search from Medline, Cochrane Library databases and research of international clinical practice guidelines. RESULTS: Genital herpes lesion is most often due to HSV2 (LE2). The risk of HSV seroconversion during pregnancy is 1 to 5% (LE2). Genital herpes ulceration during pregnancy in a woman with history of genital herpes corresponds with a recurrence...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29132767/-management-of-pregnant-women-with-first-episode-of-genital-herpes-guidelines-for-clinical-practice-from-the-french-college-of-gynecologists-and-obstetricians-cngof
#18
N Sananès
OBJECTIVE: To provide guidelines for the management of first episode genital herpes during pregnancy and in the immediate postpartum period. METHODS: MedLine and Cochrane Library databases search and review of the main foreign guidelines. RESULTS: In case of first episode genital herpes during pregnancy, antiviral treatment with acyclovir (200mg 5 times daily) or valacyclovir (1000mg twice daily) for 5 to 10 days is recommended (grade C)...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29128807/apigenin-a-novel-candidate-involving-herb-drug-interaction-hdi-interacts-with-organic-anion-transporter-1-oat1
#19
Ting Wu, Haixin Li, Jiasheng Chen, Ying Cao, Weimin Fu, Pingzheng Zhou, Jianxin Pang
BACKGROUND: Apigenin is a flavonoid compound, widely distributed in natural plants. Various studies have suggested that apigenin has inhibitory effects towards several drug transporters, such as the organic anion transporting (OAT) polypeptides, 1B1 and 1B3 (OATP1B1 and OATP1B3). However, the mechanism by which apigenin interacts with OAT1 has not been well studied. METHODS: MDCK cells stably-expressing OAT1 were used to examine the inhibitory effects of apigenin on OAT1...
June 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29123419/encephalitis-treatment-a-case-report-with-long-term-follow-up-of-ebv-pcr-in-cerebrospinal-fluid
#20
Fnu Zarlasht, Mashal Salehi, Mohammad Abu-Hishmeh, Muzammil Khan
Background: Epstein-Barr virus (EBV) has been found to cause infectious mononucleosis multiple times, but has been associated rarely with EBV encephalitis. Also, whenever it is diagnosed, it is always treated symptomatically. Case report: A case of confirmed EBV encephalitis is presented, which was treated with antiviral therapy resulting in complete clearance of the virus in cerebrospinal fluid and minimal neurologic symptoms after hospital discharge. Conclusion: The Infectious Diseases Society of America guidelines state that intravenous acyclovir is not recommended for EBV-related encephalitis...
2017: International Journal of General Medicine
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