keyword
MENU ▼
Read by QxMD icon Read
search

Acyclovir

keyword
https://www.readbyqxmd.com/read/29034838/formulation-optimization-and-evaluation-of-organogel-for-topical-delivery-of-acyclovir
#1
Smita Bonde, Chandrakant Bonde, Nisarg Mavani
BACKGROUND: The conventional acyclovir topical therapy has a low efficacy, due to the lack of penetration of a sufficient amount of drug to the target site. OBJECTIVE: The aim of this work was to formulate and optimize organogel containing acyclovir to enhance the penetration and retention time of acyclovir in the basal epidermis, site of Herpes simplex virus infections. METHODS: Microemulsion based organogel containing acyclovir was developed using the combination of surfactants, polar and nonpolar solvents...
October 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28992265/treatment-with-quadrivalent-human-papillomavirus-vaccine-for-juvenile-onset-recurrent-respiratory-papillomatosis-case-report-and-review-of-the-literature
#2
Tomohiro Katsuta, Yusuke Miyaji, Paul A Offit, Kristen A Feemster
Although juvenile-onset recurrent respiratory papillomatosis (JoRRP) generally involves a benign tumor on the larynx and other respiratory tract areas, almost all patients with this disease require repeated surgical intervention (to prevent airway obstruction during the course of illness) and various adjuvant therapies such as interferon, cidofovir, acyclovir, ribavirin, indole-3-carbinol, HspE7, mumps vaccine, photodynamic therapy, propranolol, cimetidine, and bevacizumab. Some case reports recently described the effectiveness of the quadrivalent human papillomavirus vaccine (HPV4) as an adjuvant therapy...
August 8, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28991360/low-dose-naltrexone-a-novel-treatment-for-hailey-hailey-disease
#3
V Campbell, C McGrath, A Corry
Hailey-Hailey disease (chronic benign familial pemphigus) is a rare inherited dermatosis typically characterised by erosions at intertriginous sites preceded by minor trauma or stress. We report a case of treatment resistant Hailey-Hailey disease, having failed topical and oral steroids, prophylactic acyclovir and doxycycline, and systemic therapies including dapsone, acitretin and ciclosporin. Low dose naltrexone (LDN) 4.5mg one daily was commenced following an incidental benefit in this patient's similarly affected sister...
October 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28985733/topical-use-of-5-acyclovir-cream-for-the-treatment-of-occult-and-verrucous-equine-sarcoids-a-double-blinded-placebo-controlled-study
#4
Maarten Haspeslagh, Mireia Jordana Garcia, Lieven E M Vlaminck, Ann M Martens
BACKGROUND: Previous studies mention the use of topical acyclovir for the treatment of equine sarcoids. Success rates vary and since the bovine papillomavirus (BPV) lacks the presence of a kinase necessary to activate acyclovir, there is no proof of its activity against equine sarcoids. RESULTS: Twenty-four equine sarcoids were topically treated with acyclovir cream and 25 with a placebo. Both creams were applied twice daily during 6 months. Before the start of the treatment and further on a monthly basis, photographs and swabs were obtained...
October 6, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28982161/novel-multipurpose-pod-intravaginal-ring-for-the-prevention-of-hiv-hsv-and-unintended-pregnancy-pharmacokinetic-evaluation-in-a-macaque-model
#5
James M Smith, John A Moss, Priya Srinivasan, Irina Butkyavichene, Manjula Gunawardana, Rob Fanter, Christine S Miller, Debbie Sanchez, Flora Yang, Shanon Ellis, Jining Zhang, Mark A Marzinke, Craig W Hendrix, Amita Kapoor, Marc M Baum
Globally, women bear an uneven burden for sexual HIV acquisition. Results from two clinical trials evaluating intravaginal rings (IVRs) delivering the antiretroviral agent dapivirine have shown that protection from HIV infection can be achieved with this modality, but high adherence is essential. Multipurpose prevention technologies (MPTs) can potentially increase product adherence by offering protection against multiple vaginally transmitted infections and unintended pregnancy. Here we describe a coitally independent, long-acting pod-IVR MPT that could potentially prevent HIV and HSV infection as well as unintended pregnancy...
2017: PloS One
https://www.readbyqxmd.com/read/28981391/posterior-scleritis-with-choroidal-effusion-secondary-to-herpes-zoster-ophthalmicus
#6
Edmund Tsui, Soshian Sarrafpour, Yasha S Modi
PURPOSE: To describe a case of posterior scleritis with serous choroidal detachment that occurred as an acute complication of herpes zoster ophthalmicus (HZO). METHODS: Retrospective case report. RESULTS: A 75-year-old female presented with 3 days of painful, decreased vision in her left eye 1 week after being diagnosed with HZO. She had unilateral crusted vesicular lesions in the V1 dermatomal distribution and corneal pseudodendrites. Funduscopic examination demonstrated a large choroidal detachment in her left eye...
October 5, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28971780/herpes-labialis-an-update
#7
Alexander K C Leung, Benjamin Barankin
BACKGROUND: Herpes labialis is characterized by recurrent vesicular eruptions primarily on the lips and perioral skin. The condition is contagious, can cause significant discomfort/pain, and can have an adverse effect on quality of life. OBJECTIVE: To update the evaluation and treatment of herpes labialis. METHODS: A PubMed search was completed in Clinical Queries using the key term "herpes labialis". Patents were searched using the key term "herpes labialis" from www...
October 3, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28966663/alemtuzumab-in-the-long-term-treatment-of-relapsing-remitting-multiple-sclerosis-an-update-on-the-clinical-trial-evidence-and-data-from-the-real-world
#8
Tjalf Ziemssen, Katja Thomas
Alemtuzumab is a humanized monoclonal antibody approved for the treatment of relapsing-remitting multiple sclerosis (RRMS), given as two annual courses on five consecutive days at baseline and on three consecutive days 12 months later. Here we provide an update on the long-term efficacy and safety of alemtuzumab in RRMS, including real-world experience, and advances in our understanding of its mechanism of action. Recent data from the phase II/III extension study have demonstrated that alemtuzumab reduces relapse rates, disability worsening, and the rate of brain volume loss over the long term, with many patients achieving no evidence of disease activity...
October 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28966468/fetal-ventriculomegaly-and-herpes-encephalitis-following-primary-maternal-herpes-simplex-infection
#9
Jenna K Sloan, Chase R Cawyer, Nathan S Drever
Uteroplacental transmission of a primary herpes simplex virus (HSV) infection in pregnancy has been reported; however, HSV ventriculomegaly of the neonate has not been well documented in utero. We present a case of a 19-year-old woman who developed a primary HSV outbreak at 17 weeks of gestation and was treated with acyclovir. A congenital malformation scan at 18 weeks of gestation demonstrated no fetal abnormalities; however, an ultrasound at 33 weeks showed a new finding of ventriculomegaly. Additionally, hydrocephalus was confirmed with magnetic resonance imaging...
October 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28962808/herpes-virus-encephalitis-in-adults-current-knowledge-and-old-myths
#10
REVIEW
Alejandro A Rabinstein
Herpes simplex virus (HSV) encephalitis is uncommon in clinical practice, but is frequently suspected in patients with acute alterations of consciousness. Symptoms and physical signs are nonspecific, and diagnostic confirmation typically hinges on demonstration of viral DNA in cerebrospinal fluid. Brain MRI is helpful in diagnosis and provides prognostic information. Early initiation of intravenous acyclovir is essential to optimize the patient's chances of favorable recovery. HSV encephalitis can trigger an autoimmune reaction with the possible appearance of antibodies to neuronal surface antigens...
November 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28956914/inhibition-of-herpes-simplex-viruses-by-cationic-dextran-derivatives
#11
Magdalena Pachota, Katarzyna Klysik, Aleksandra Synowiec, Justyna Ciejka, Krzysztof Szczubiałka, Krzysztof Pyrć, Maria Nowakowska
Human herpesviruses are among the most prevalent pathogens and currently there are no drugs available that could cure diseases induced by them. The most widely utilized antiherpes drugs, acyclovir and its derivatives, have serious limitations, such as low bioavailability and severe side effects. The current paper reports on the synthesis and characterization of cationic dextran derivatives (DEXxDSy) of various molecular weights and various degrees of substitution with ammonium groups, which were tested as antiherpes agents...
October 6, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28956767/the-exonuclease-activity-of-hsv-1-ul12-is-required-for-the-production-of-viral-dna-that-can-be-packaged-to-produce-infectious-virus
#12
Lorry M Grady, Renata Szczepaniak, Ryan P Murelli, Takeshi Masaoka, Stuart F J Le Grice, Dennis L Wright, Sandra K Weller
The Herpes simplex virus type I alkaline nuclease, UL12, has 5' to 3' exonuclease activity and shares homology with nucleases from other members of the Herpesviridae family. We previously reported that a UL12 null virus exhibits a severe defect in viral growth. To determine whether the growth defect was a result of loss of nuclease activity or another function of UL12, we introduced an exonuclease-inactivating mutation into the viral genome. The recombinant virus, UL12-D340E (D340E), behaved identically to the null virus (AN-1) in virus yield experiments, exhibiting a 4-log decrease in the production of infectious virus...
September 27, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28945127/efficacy-of-the-early-administration-of-valacyclovir-hydrochloride-for-the-treatment-of-neuropathogenic-equine-herpesvirus-type-1-infection-in-horses
#13
Lara K Maxwell, Bradford G Bentz, Lyndi L Gilliam, Jerry W Ritchey, Nicola Pusterla, R Eberle, Todd C Holbrook, Dianne McFarlane, Grant B Rezabek, James Meinkoth, Chase Whitfield, Carla L Goad, George P Allen
OBJECTIVE To determine whether prophylactic administration of valacyclovir hydrochloride versus initiation of treatment at the onset of fever would differentially protect horses from viral replication and clinical disease attributable to equine herpesvirus type-1 (EHV-1) infection. ANIMALS 18 aged mares. PROCEDURES Horses were randomly assigned to receive an oral placebo (control), treatment at detection of fever, or prophylactic treatment (initiated 1 day prior to viral challenge) and then inoculated intranasally with a neuropathogenic strain of EHV-1...
October 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28944968/pediatric-vaccine-strain-herpes-zoster-a-case-series
#14
Sean Dreyer, Peera Hemarajata, Marcia Hogeling, Gregory P Henderson
BACKGROUND/OBJECTIVES: Herpes zoster (HZ) is caused by reactivation of the varicella zoster virus (VZV), and typically causes a painful, vesicular, dermatomal rash in adults over the age of fifty. However, HZ has been known to present in immunocompetent pediatric patients, which account for under 1% of total cases. Pediatric cases are typically caused by natural infection with VZV, but among vaccinated children up to half of cases can be due to vaccine-strain VZV. We present two such cases of vaccine-strain HZ in pediatric patients...
September 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28943043/discovery-of-potent-antiviral-hsv-1-quinazolinones-and-initial-structure-activity-relationship-studies
#15
Carla E Brown, Tiffany Kong, James McNulty, Leonardo D'Aiuto, Kelly Williamson, Lora McClain, Paolo Piazza, Vishwajit L Nimgaonkar
The discovery of antiviral activity of 2,3-disubstituted quinazolinones, prepared by a one-pot, three-component condensation of isatoic anhydride with amines and aldehydes, against Herpes Simplex Virus (HSV)-1 is reported. Sequential iterative synthesis/antiviral assessment allowed structure-activity relationship (SAR) generation revealing synergistic structural features required for potent anti-HSV-1 activity. The most potent derivatives show greater efficacy than acyclovir against acute HSV-1 infections in neurons and minimal toxicity to the host...
September 14, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28942398/disseminated-herpes-zoster-causing-acute-respiratory-distress-syndrome-in-an-immunocompetent-patient
#16
David M Rudinsky, Kim Jordan
Disseminated cutaneous varicella herpes zoster with visceral involvement is rare and seen almost exclusively in immunocompromised patients. We describe an unusual case of fulminant herpes zoster (HZ) in a healthy, immunocompetent 37-year-old woman. She initially presented to an urgent care centre with a classic HZ rash localised to her neck, and upper respiratory symptoms and was treated with prednisone and cephalexin. Within 1 week, the rash became diffuse and her clinical status rapidly deteriorated with development of severe acute respiratory distress syndrome...
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28942073/update-on-the-management-of-infectious-keratitis
#17
REVIEW
Ariana Austin, Tom Lietman, Jennifer Rose-Nussbaumer
Infectious keratitis is a major global cause of visual impairment and blindness, often affecting marginalized populations. Proper diagnosis of the causative organism is critical, and although culture remains the prevailing diagnostic tool, newer techniques such as in vivo confocal microscopy are helpful for diagnosing fungus and Acanthamoeba. Next-generation sequencing holds the potential for early and accurate diagnosis even for organisms that are difficult to culture by conventional methods. Topical antibiotics remain the best treatment for bacterial keratitis, and a recent review found all commonly prescribed topical antibiotics to be equally effective...
September 20, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28939476/recurrent-herpetic-keratitis-despite-antiviral-prophylaxis-a-virological-and-pharmacological-study
#18
Antoine Rousseau, David Boutolleau, Karine Titier, Tristan Bourcier, Christophe Chiquet, Michel Weber, Joseph Colin, Julie Gueudry, Mohamed M'Garrech, Bahram Bodaghi, Sonia Burrel, Henri Agut, Claire Deback, Marc Labetoulle
Recurrent herpes simplex keratitis (HSK) is a leading infectious cause of blindness in industrialized countries. Antiviral prophylaxis (AVP) may fail to prevent recurrence of HSK due to viral resistance, inadequate dosing, or poor patient compliance. In this prospective multicenter study, we enrolled immunocompetent patients with recurrent HSK despite AVP. Ocular samples were tested by PCR for herpes simplex virus 1 (HSV-1). HSV-1 drug resistance was assessed with a genotypic assay based on UL23 and UL30 gene sequencing...
September 20, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28935255/a-comprehensive-approach-to-qualify-and-validate-the-essential-parameters-of-an-in-vitro-release-test-ivrt-method-for-acyclovir-cream-5
#19
Katrin I Tiffner, Isadore Kanfer, Thomas Augustin, Reingard Raml, Sam G Raney, Frank Sinner
The rate of release of an active pharmaceutical ingredient (API) from a topical semisolid dosage form can be influenced by its physical and structural properties. An In Vitro Release Test (IVRT) is an established method to characterize this rate of API release and compare the underlying sameness in product quality characteristics. The purpose of this work was to validate an IVRT method to compare acyclovir cream, 5% products. However, despite widespread use of the IVRT since 1997, there was no established approach to validate an IVRT method...
September 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28924117/successful-treatment-of-herpes-simplex-virus-hsv-1-associated-hemophagocytic-lymphohistiocytosis-hlh-with-acyclovir-a-case-report-and-literature-review
#20
Tomohiro Yabushita, Satoshi Yoshioka, Yusuke Koba, Yuichirou Ono, Nobuhiro Hiramoto, Sumie Tabata, Munehiro Itou, Norio Shimizu, Keisuke Tomii, Takayuki Ishikawa
Hemophagocytic lymphohistiocytosis (HLH) associated with herpes simplex virus (HSV)-1 infection (HSV-1-HLH) is uncommon and is potentially fatal without appropriate treatment. We herein report the case of an adult patient with HSV-1-HLH who was successfully treated with acyclovir. A 69-year-old man developed fever, pancytopenia and liver enzyme elevation after the resolution of pneumonia. These findings and the presence of hemophagocytosis in the patient's bone marrow were consistent with a diagnosis of HLH...
September 15, 2017: Internal Medicine
keyword
keyword
54187
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"