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https://www.readbyqxmd.com/read/28207190/diaporthe-soft-tissue-infection-in-a-heart-transplant-patient
#1
Robert M Rakita, Kevin D O'Brien, Lori Bourassa
Infections caused by Diaporthe species are very uncommon. We describe a heart transplant recipient 14 years post transplant who developed a soft tissue fungal infection due to a Diaporthe species that responded well to surgical excision and posaconazole therapy. The Aspergillus galactomannan index was markedly elevated, and returned to normal following treatment. Solid organ transplant patients remain at risk of infection long after transplant and should be counseled about risk avoidance. This article is protected by copyright...
February 16, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28203579/rhabdomyolysis-following-initiation-of-posaconazole-use-for-antifungal-prophylaxis-in-a-patient-with-relapsed-acute-myeloid-leukemia-a-case-report
#2
Mayur D Mody, Deepak Ravindranathan, Harpaul S Gill, Vamsi K Kota
Posaconazole is a commonly used medication for antifungal prophylaxis in patients with high-risk acute leukemia, such as acute myeloid leukemia. Despite clinical data that show that posaconazole is superior to other antifungal prophylaxis medications, posaconazole is known to have many side effects and drug-drug interactions. We present a patient who developed rhabdomyolysis after being started on posaconazole for prophylaxis in the setting of relapsed acute myeloid leukemia.
January 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28196695/impact-of-erg3-mutations-and-expression-of-ergosterol-genes-controlled-by-upc2-and-ndt80-in-candida-parapsilosis-azole-resistance
#3
Joana Branco, Mihaela Ola, Raquel M Silva, Elizangela Fonseca, Nuno C Gomes, Cláudia Martins-Cruz, Ana P Silva, Ana Silva-Dias, Cidália Pina-Vaz, Claire Erraught, Lorraine Brennan, Acácio Gonçalves Rodrigues, Geraldine Butler, Isabel M Miranda
OBJECTIVES: C. parapsilosis is a health care related fungal pathogen particularly common among immunocompromised patients. Our understanding of antifungal resistance mechanisms in C. parapsilosis remains very limited. We previously described an azole-resistant strain of C. parapsilosis (BC014RPSC), obtained following exposure in vitro to posaconazole. Resistance was associated with overexpression of ergosterol biosynthetic genes (ERG genes), together with the transcription factors UPC2 (CPAR2-207280) and NDT80 (CPAR2-213640)...
February 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28191796/the-cost-of-treating-mucormycosis-with-isavuconazole-compared-with-standard-therapy-in-the-uk
#4
Emma Bagshaw, Daniel Kuessner, Jan Posthumus, Cesar Escrig, Michael Blackney, Sebastian Marcel Heimann, Oliver Andreas Cornely
AIM: Mucormycosis is a fungal infection associated with high mortality. Until recently, the only licensed treatments were amphotericin B (AMB) formulations. Isavuconazole (ISAV) is a new mucormycosis treatment. A UK-based economic model explored treatment costs with ISAV versus liposomal AMB followed by posaconazole. MATERIALS & METHODS: As a matched case-control analysis showed similar efficacy for ISAV and AMB, a cost-minimization approach was taken. Direct costs - drug acquisition, monitoring and administration, and hospitalization costs - were estimated from the National Health Service perspective...
February 13, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28190754/consistent-high-prevalence-of-exophiala-dermatitidis-a-neurotropic-opportunist-on-railway-sleepers
#5
S A Yazdanparast, S Mohseni, G S De Hoog, N Aslani, A Sadeh, H Badali
Environmental isolation of black yeasts potentially causing human disorders is essential for understanding ecology and routes of infection. Several Exophiala species show prevalence for man-made environments rich in monoaromatic compounds, such as creosote-treated or petroleum-stained railway sleepers. Ambient climatic conditions play a role in species composition in suitable habitats. Therefore, the aim of the present study was to establish the composition of Exophiala species in railway stations as a potential source of human infections in a subtropical region with evaluation of their antifungal susceptibility profiles...
February 9, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28186550/posaconazole-plasma-monitoring-in-immunocompromised-children
#6
Jessica McMahon, Yves Théorêt, Julie Autmizguine, Henrique Bittencourt, Bruce Tapiéro, Philippe Ovetchkine
No abstract text is available yet for this article.
February 10, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28180057/cutaneous-alternariosis-in-a-renal-transplant-patient-successfully-treated-with-posaconazole-case-report-and-literature-review
#7
Rajinder Bajwa, Amy L Wojciechowski, Chiu-Bin Hsiao
Cutaneous alternariosis is an uncommon fungal infection that most commonly presents in organ transplant patients on immunosuppressive therapy. There are no clinical trials or guidelines to guide treatment of this condition, however itraconazole is the most commonly used antifungal in published cases. Here we report on a case of cutaneous alternariosis in a renal transplant recipient treated with a newer antifungal, posaconazole. A review of published reports of cutaneous alternariosis since 2008 is also discussed...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28178836/nematic-like-stable-glasses-without-equilibrium-liquid-crystal-phases
#8
Jaritza Gómez, Ankit Gujral, Chengbin Huang, Camille Bishop, Lian Yu, M D Ediger
We report the thermal and structural properties of glasses of posaconazole, a rod-like molecule, prepared using physical vapor deposition (PVD). PVD glasses of posaconazole can show substantial molecular orientation depending upon the choice of substrate temperature, Tsubstrate, during deposition. Ellipsometry and IR measurements indicate that glasses prepared at Tsubstrate very near the glass transition temperature (Tg) are highly ordered. For these posaconazole glasses, the orientation order parameter is similar to that observed in macroscopically aligned nematic liquid crystals, indicating that the molecules are mostly parallel to one another and perpendicular to the interface...
February 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28167540/hypokalemia-and-hypertension-associated-with-supratherapeutic-posaconazole-levels
#9
Maryam Mahmood, Omar Abu Saleh, M Rizwan Sohail
We report a case of posaconazole toxicity in a 44 year old man with a history of diffuse large B cell lymphoma.….
February 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28161120/management-of-venetoclax-posaconazole-interaction-in-acute-myeloid-leukemia-patients-evaluation-of-dose-adjustments
#10
Suresh K Agarwal, Courtney D DiNardo, Jalaja Potluri, Martin Dunbar, Hagop M Kantarjian, Rod A Humerickhouse, Shekman L Wong, Rajeev M Menon, Marina Y Konopleva, Ahmed Hamed Salem
PURPOSE: The effect of posaconazole, a strong cytochrome P450 3A (CYP3A) inhibitor and commonly used antifungal agent, on the pharmacokinetic properties of venetoclax, a CYP3A substrate, was evaluated in patients with acute myeloid leukemia to determine the dose adjustments needed to manage this potential interaction. METHODS: Twelve patients received 20- to 200-mg ramp-up treatment with oral venetoclax and 20 mg/m(2) of intravenous decitabine on days 1 through 5, followed by 400 mg of venetoclax alone on days 6 through 20...
February 1, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28154281/fulminant-laryngeal-tracheobronchial-pulmonary-aspergillosis-a-rare-and-fatal-complication-in-allogeneic-hematopoietic-stem-cell-transplantation-recipients
#11
Tao Tao, Ying-Hui Zhang, Sheng-Li Xue, De-Pei Wu, Feng Chen
A 23-year-old man who had previously undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia was diagnosed with invasive laryngeal-tracheobronchial-pulmonary aspergillosis after presenting with a persistent dry cough at six months post-transplantation based on the findings of laryngoscopy and fiberoptic bronchoscopy. A fiberoptic bronchoscope was used to remove the obstructive material from the patient's airway and posaconazole plus caspofungin were administered to successfully to treat the patient...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28143591/a-case-report-of-intravenous-posaconazole-in-hepatic-and-renal-impairment-patient-with-invasive-aspergillus-terreus-infection-safety-and-role-of-therapeutic-drug-monitoring
#12
Pitchaya Dilokpattanamongkol, Panadda Panusitthikorn, Rasda Boonprasert, Methee Chayakulkeeree, Porpon Rotjanapan
BACKGROUND: Invasive aspergillosis (IA) is a fatal infectious complication among immunocompromised patients. Aspergillus terreus, the fourth common species can be difficult to treat due to a unique resistance pattern. To date, there has been no report on safety and dose adjustment when intravenous posaconazole is selected in hepatic and renal impairment patient. We present a rare case of intravenous posaconazole use in a hepatic and renal impairment patient with invasive A. terreus pulmonary infection...
January 31, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28139861/species-diversity-antifungal-susceptibility-and-phenotypic-and-genotypic-characterisation-of-exophiala-spp-infecting-patients-in-different-medical-centres-in-brazil
#13
Wendy C Silva, Sarah S Gonçalves, Daniel W C L Santos, Ana Carolina B Padovan, Fernando C Bizerra, Analy S A Melo
The Exophiala genus is responsible for many superficial and invasive infections resulting from black fungi. Identification of Exophiala at the species level is based on morphological observations complemented by molecular tests. The aim of this study was to identify 23 clinical isolates of Exophiala spp. and evaluate the antifungal susceptibility to seven different agents. Molecular identification was based on an analysis of ITS region of rDNA using genomic databases. The micromorphology was evaluated by microculture and scanning electron microscopy...
January 31, 2017: Mycoses
https://www.readbyqxmd.com/read/28139856/epidemiological-investigation-of-candida-species-causing-bloodstream-infection-in-paediatric-small-bowel-transplant-recipients
#14
Mallory J Suhr, João Carlos Gomes-Neto, Nabaraj Banjara, Diana F Florescu, David F Mercer, Peter C Iwen, Heather E Hallen-Adams
Small bowel transplantation (SBT) can be a life-saving medical procedure. However, these recipients experience high risk of bloodstream infections caused by Candida. This research aims to characterise the SBT recipient gut microbiota over time following transplantation and investigate the epidemiology of candidaemia in seven paediatric patients. Candida species from the recipients' ileum and bloodstream were identified by internal transcribed spacer sequence and distinguished to strain by multilocus sequence typing and randomly amplified polymorphic DNA...
January 31, 2017: Mycoses
https://www.readbyqxmd.com/read/28133872/comparison-of-two-in%C3%A2-vitro-antifungal-sensitivity-tests-and-monitoring-during-therapy-of-sporothrix-schenckii-sensu-stricto-in-malaysian-cats
#15
Hock Siew Han, Rui Kano, Charles Chen, Chiara Noli
BACKGROUND: Feline sporotrichosis is common in Malaysia. Thermosensitivity and effects of azole treatment on fungal susceptibility are unknown. OBJECTIVES: To evaluate thermotolerance and antifungal susceptibility of feline Malaysian Sporothrix isolates, compare microdilution (MD) and E-test results, and investigate changes in susceptibility during azole therapy. METHODS: Sporothrix schenckii sensu stricto was isolated from 44 cats. Thermotolerance was determined via culture at 37°C for 7 days...
February 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28131847/inhibition-of-11%C3%AE-hydroxysteroid-dehydrogenase-2-by-the-fungicides-itraconazole-and-posaconazole
#16
Katharina R Beck, Murielle Bächler, Anna Vuorinen, Sandra Wagner, Muhammad Akram, Ulrich Griesser, Veronika Temml, Petra Klusonova, Hideaki Yamaguchi, Daniela Schuster, Alex Odermatt
Impaired 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2)-dependent cortisol inactivation can lead to electrolyte dysbalance, hypertension and cardiometabolic disease. Furthermore, placental 11β-HSD2 essentially protects the fetus from high maternal glucocorticoid levels, and its impaired function has been associated with altered fetal growth and a higher risk for cardio-metabolic diseases in later life. Despite its important role, 11β-HSD2 is not included in current off-target screening approaches. To identify potential 11β-HSD inhibitors amongst approved drugs, a pharmacophore model was used for virtual screening, followed by biological assessment of selected hits...
January 25, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28131716/nosocomial-fungemia-by-candida-auris-first-four-reported-cases-in-continental-europe
#17
Alba Cecilia Ruiz Gaitán, Ana Moret, José Luis López Hontangas, José Miguel Molina, Ana Isabel Aleixandre López, Alicia Hernández Cabezas, Juan Mollar Maseres, Rabat Chouman Arcas, María Dolores Gómez Ruiz, Miguel Ángel Chiveli, Emilia Cantón, Javier Pemán
BACKGROUND: Candida auris is an emerging multidrug-resistant yeast that can cause invasive infections and is associated with high mortality. It is typically resistant to fluconazole and voriconazole and, some cases, also to echinocandins and amphotericin B. This species, phylogenetically related to Candida haemulonii, is frequently misidentified by commercial identification techniques in clinical laboratories; therefore, the real prevalence of C. auris infections may be underestimated...
January 25, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28131025/an-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-method-for-the-therapeutic-drug-monitoring-of-isavuconazole-and-seven-other-antifungal-compounds-in-plasma-samples
#18
Balthazar Toussaint, Fanny Lanternier, Christian Woloch, Denis Fournier, Manon Launay, Eliane Billaud, Eric Dannaoui, Olivier Lortholary, Vincent Jullien
A new analytical method was developed for the routine Therapeutic Drug Monitoring of 8 antifungals compounds in 50μL of plasma: isavuconazole (ISZ), voriconazole (VRZ), posaconazole (PSZ), fluconazole (FCZ), caspofungin (CSF), flucytosine (5FC), itraconazole (ITZ) and its metabolite OH-itraconazole (OH-ITZ). After adding 50μL of the internal standard, which consisted in a mixture of the deuterated isotopes of the quantified compounds, the sample treatment consisted in a simple protein precipitation with 400μL of acetonitrile...
January 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28124220/in-vitro-antifungal-susceptibility-of-oral-candida-isolates-from-patients-suffering-from-caries-and-chronic-periodontitis
#19
Janire De-la-Torre, María Esther Ortiz-Samperio, Cristina Marcos-Arias, Xabier Marichalar-Mendia, Elena Eraso, María Ángeles Echebarria-Goicouria, José Manuel Aguirre-Urizar, Guillermo Quindós
Caries and chronic periodontitis are common oral diseases where a higher Candida colonization is reported. Antifungal agents could be adjuvant drugs for the therapy of both clinical conditions. The aim of the current study has been to evaluate the in vitro activities of conventional and new antifungal drugs against oral Candida isolates from patients suffering from caries and/or chronic periodontitis. In vitro activities of amphotericin B, fluconazole, itraconazole, miconazole, nystatin, posaconazole and voriconazole against 126 oral Candida isolates (75 Candida albicans, 18 Candida parapsilosis, 11 Candida dubliniensis, six Candida guilliermondii, five Candida lipolytica, five Candida glabrata, four Candida tropicalis and two Candida krusei) from 61 patients were tested by the CLSI M27-A3 method...
January 25, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28096163/large-scale-evaluation-of-in-vitro-amphotericin-b-triazole-and-echinocandin-activity-against-coccidioides-species-from-united-states-institutions
#20
George R Thompson, Bridget M Barker, Nathan P Wiederhold
Large-scale testing of Coccidioides isolates has not previously been performed, nor has the frequency of clinical isolates with elevated amphotericin B or triazole MICs been evaluated. Coccidioides isolates (n=581) underwent antifungal susceptibility testing. Elevated MIC values were observed for: fluconazole (MIC ≥16 μg/ml, 37.3% of isolates; ≥32 μg/ml, 7.9%), itraconazole (1.0% ≥2 μg/ml), posaconazole (1.0% ≥1 μg/ml), and voriconazole (1.2% ≥2 μg/ml). However mould-active triazoles exhibited low MICs for the majority of isolates tested...
January 17, 2017: Antimicrobial Agents and Chemotherapy
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