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https://www.readbyqxmd.com/read/28440258/neuroretinitis-as-presenting-and-the-only-presentation-of-lyme-disease-diagnosis-and-management
#1
Brahm Prakash Guliani, Sandeep Kumar, Neha Chawla, Anuj Mehta
We present a case of neuroretinitis as presenting and the only presentation of Lyme disease in a 25-year-old female who visited hilly areas in the Himalayas of North India. She presented with right eye sudden and painless blurring of vision. Her vision at presentation was 20/60. She had fundus examination; fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) imaging showed classical features of neuroretinitis. No other organ was involved. Oral steroids were prescribed and relevant investigations sent for noninfective and infective causes...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28437585/chronic-intestinal-electrical-stimulation-improves-glucose-intolerance-and-insulin-resistance-in-diet-induced-obesity-rats
#2
Shiying Li, Weijian Zhu, Sujuan Zhang, Jiande Dz Chen
OBJECTIVE: Obesity is a contributing factor to insulin resistance and type 2 diabetes. The aim of this study was to study the therapeutic potential of intestinal electrical stimulation (IES) for obesity and associated glucose intolerance and insulin resistance in diet-induced obesity (DIO) rats. METHODS: DIO rats were divided into two groups to receive sham or IES for 8 weeks. Oral glucose tolerance and insulin tolerance tests were performed. Gastric emptying and small bowel transit tests were performed...
April 24, 2017: Obesity
https://www.readbyqxmd.com/read/28437263/a-randomised-trial-to-evaluate-preoperative-oral-carbohydrate-administration-on-insulin-resistance-in-off-pump-coronary-artery-bypass-patients
#3
Bora Lee, Sarah Soh, Jae-Kwang Shim, Ha Y Kim, Hyelin Lee, Young-Lan Kwak
BACKGROUND: In fasting cardiac surgery patients, preoperative carbohydrate (CHO) drink intake attenuated insulin resistance and improved cardiac metabolism, although its beneficial effects were not evident after cardiac surgery possibly due to cardiopulmonary bypass-related extreme systemic inflammation. OBJECTIVE: We aimed to evaluate whether preoperative CHO intake affected insulin resistance and free-fatty acid (FFA) concentrations in off-pump coronary revascularisation...
April 21, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28436198/effects-of-selenium-on-apoptosis-and-abnormal-amino-acid-metabolism-induced-by-excess-fatty-acid-in-isolated-rat-hepatocytes
#4
Zhigang Zhang, Siyu Li, Huijie Jiang, Biying Liu, Zhanjun Lv, Changming Guo, Haili Zhang
SCOPE: Increased serum free fatty acid (FFA) occurs in subjects with non-alcoholic fatty liver disease (NAFLD) and also triggers oxidative stress, apoptosis, and insulin resistance. Selenium (Se) is an antioxidant agent. However, the effect of Se on NAFLD or diabetes is still unclear. We investigated the effect of Se on apoptosis and abnormal amino acid metabolism initiated by excess FFA in isolated rat hepatocytes. METHODS AND RESULTS: Primary hepatocytes from rats were isolated and exposed to excessive FFA (0...
April 24, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28431559/effects-of-whole-grain-rye-with-and-without-resistant-starch-type-2-supplementation-on-glucose-tolerance-gut-hormones-inflammation-and-appetite-regulation-in-an-11-14-5%C3%A2-hour-perspective-a-randomized-controlled-study-in-healthy-subjects
#5
Jonna C Sandberg, Inger M E Björck, Anne C Nilsson
BACKGROUND: The prevalence of obesity is increasing worldwide and prevention is needed. Whole grain has shown potential to lower the risk of obesity, cardiovascular disease and type 2 diabetes. One possible mechanism behind the benefits of whole grain is the gut fermentation of dietary fiber (DF), e.g. non-starch polysaccharides and resistant starch (RS), in whole grain. The purpose of the study is to investigate the effect of whole grain rye-based products on glucose- and appetite regulation...
April 21, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28429532/neu1-sialidase-interacts-with-perilipin-1-on-lipid-droplets-and-inhibits-lipolysis-in-3t3-l1-adipocytes
#6
Yujin Natori, Miwako Nasui, Fumiko Kihara-Negishi
Fatty acids are stored within adipocytes in lipid droplets (LDs) as triacylglycerol (TG), which is converted to free fatty acid (FFA) and glycerol via lipolysis. Increased plasma FFA levels in obesity are associated with several clinical conditions. We previously found that Neu1 activity is aberrant in the epididymal fat and liver of obese and diabetic mice. Here, we examined involvement of Neu1 in lipolysis in 3T3-L1 adipocytes. Small interfering RNA against Neu1 was introduced into adipocytes, and glycerol concentrations were measured in the culture medium...
April 21, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28429464/inflammatory-features-of-frontal-fibrosing-alopecia
#7
Sophia A Ma, Sotonye Imadojemu, Kenneth Beer, John T Seykora
INTRODUCTION: Frontal fibrosing alopecia (FFA) is a cicatricial alopecia typically occurring in post-menopausal women. The etiology and pathophysiology of FFA is poorly understood but thought to be immune mediated. This study aims to further explore the extent of fibrosis and the inflammatory microenvironment by characterizing Langerhans cells (LCs), helper T cells, cytotoxic T cells, and B cells near hair follicles in FFA. METHODS: 11 paraffin-embedded tissues from patients with a clinical and histopathologic diagnosis of FFA were selected for immunohistochemical studies using CD3, CD4, CD8, CD1a, and CD20...
April 21, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28426907/frontal-fibrosing-alopecia-clinical-and-prognostic-classification
#8
O M Moreno-Arrones, D Saceda-Corralo, P Fonda-Pascual, A R Rodrigues-Barata, D Buendía-Castaño, A Alegre-Sánchez, C Pindado-Ortega, M Molins, D Perosanz, G Segurado-Miravalles, P Jaén, S Vañó-Galván
BACKGROUND: Frontal fibrosing alopecia (FFA) is a chronic scarring alopecia with an unpredictable evolution. There are no current classifications of this disease that may predict its prognosis. OBJECTIVE: To analyze the differences in clinical presentation and evolution of FFA patients and to create a clinical and prognostic classification METHODS: We conducted a retrospective analytical study of FFA patients. Clinical characteristics of frontal hairline recession were used as the sorting variable between patterns of presentation...
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28425842/estradiol-does-not-directly-regulate-adipose-lipolysis
#9
Tara L MacDonald, Rebecca MacPherson, Laura Castellani, Daniel Cervone, Eoin Anderson, David C Wright, David J Dyck
The mechanisms by which estradiol modulates adipose lipolysis are poorly understood. We sought to measure basal and β3-stimulated indices of lipoysis (FFAs, glycerol) in vivo in E2 deficient or supplemented rats, and ex vivo with direct acute E2 exposure. For 2 weeks, ovariectomized (OVX) and OVX rats treated with a daily oral dose of E2 (OVX E2) were pairfed to SHAM controls (n = 12 per group). Adipocyte size was modestly (∼40%) increased in OVX rats, but did not reach significance (p = 0.2). After 2 weeks, half of the animals in each group received an in vivo injection of saline or 1 mg/kg of the β3 agonist CL 316, 243...
January 27, 2017: Adipocyte
https://www.readbyqxmd.com/read/28421342/selective-retina-therapy-with-automatic-real-time-feedback-controlled-dosimetry-for-chronic-central-serous-chorioretinopathy-in-korean-patients
#10
Young Gun Park, Seungbum Kang, Minhee Kim, Nari Yoo, Young Jung Roh
PURPOSE: To evaluate the safety and efficacy of selective retina therapy (SRT) with real-time feedback-controlled dosimetry (RFD) in the treatment of chronic central serous chorioretinopathy (CSC). METHODS: In this retrospective case series study, 50 eyes of 49 patients with chronic CSC demonstrating focal or diffuse foveal leakages on fundus fluorescein angiography (FFA) were included. Following evaluation of test spots at temporal arcades, SRT (wavelength 527 nm, pulse repetition rate 100 Hz, pulse energy ramp with maximal 15 pulses) with retinal spot diameter of 200 μm was applied to the areas of each leakage observed on fluorescein angiography...
April 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28416878/imitation-of-soymilk-cow-s-milk-mixed-enzyme-modified-cheese-their-composition-proteolysis-lipolysis-and-sensory-properties
#11
Barkat Ali, Kiran Yasmin Khan, Hamid Majeed, Lei Xu, Fengfeng Wu, Han Tao, Xueming Xu
Combined use of soymilk-cow's milk is a novel approach in food industry and has great potential to developed products with numerous health benefits. This study aimed to develop the enzyme-modified cheeses (EMCs) using soymilk-cow's milk. The curd was hydrolysed using combination of proteinases/peptidase to produce a range of proteolysed products followed by lipolysis to create flavoured EMCs. Results showed that enzymes led to an increase in amino acids (AA), free fatty acids (FFA), complex volatiles, and improved sensory attributes...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28415630/resveratrol-alleviates-ffa-and-ccl4-induced-apoptosis-in-hepg2-cells-via-restoring-endoplasmic-reticulum-stress
#12
Fenghua Li, Yang Yang, Lili Yang, Kai Wang, Xing Zhang, Yunlong Zong, Yixin Ding, Changhong Wang, Li Zhang, Guang Ji
Cell apoptosis often induces inflammation and injury in the liver, with endoplasmic reticulum (ER) stress as the most possible reason. Resveratrol (RSV) has been shown to prevent hepatic steatosis and alleviate apoptosis, however, the exact mechanisms underlying the effects still need to be explored. Here we co-cultured HepG2 cells with free fatty acid (FFA) solution (oleic acid: palmitic acid = 2:1) and then exposed to a carbon tetrachloride (CCl4) solution to induce apoptosis. To evaluate the therapeutic effects, RSV (2...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411027/%C3%AE-caryophyllene-reduces-atherogenic-index-and-coronary-risk-index-in-hypercholesterolemic-rats-the-involvement-of-cardiac-oxidative-damage
#13
Matheus D Baldissera, Carine F Souza, Thirssa H Grando, Lenita M Stefani, Silvia G Monteiro
Hypercholesterolemia and cardiac oxidative damage have been implicated in the pathophysiology of atherosclerosis. In earlier studies, treatment using natural phytocannabinoid β-caryophyllene caused a hypolipemic effect, as well as ameliorated hepatic oxidative damage. In this regard, the present study aimed to investigate whether β-caryophyllene treatment was able to protect the cardiac tissue against hypercholesterolemic atherosclerosis, and to investigate the involvement of antioxidant mechanisms in this effect using a model of hypercholesterolemia induced by Triton WR-1339...
April 12, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28393901/changes-in-scd-gene-dna-methylation-after-bariatric-surgery-in-morbidly-obese-patients-are-associated-with-free-fatty-acids
#14
Sonsoles Morcillo, Gracia Mª Martín-Núñez, Sara García-Serrano, Carolina Gutierrez-Repiso, Francisca Rodriguez-Pacheco, Sergio Valdes, Montserrat Gonzalo, Gemma Rojo-Martinez, Francisco J Moreno-Ruiz, Alberto Rodriguez-Cañete, Francisco Tinahones, Eduardo García-Fuentes
Stearoyl CoA Desaturase-1 (SCD) is considered as playing an important role in the explanation of obesity. The aim of this study was to evaluate whether the DNA methylation SCD gene promoter is associated with the metabolic improvement in morbidly obese patients after bariatric surgery. The study included 120 subjects with morbid obesity who underwent a laparoscopic Roux-en Y gastric by-pass (RYGB) and a control group of 30 obese subjects with a similar body mass index (BMI) to that found in morbidly obese subjects six months after RYGB...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28388904/effect-of-traditional-chinese-medicine-formula-sinisan-on-chronic-restraint-stress-induced-nonalcoholic-fatty-liver-disease-a-rat-study
#15
Fafeng Cheng, Chongyang Ma, Xueqian Wang, Changming Zhai, Guoli Wang, Xiaolin Xu, Jie Mu, Changxiang Li, Zisong Wang, Xiaoyu Zhang, Wenchao Yue, Xin Du, Yajun Lian, Wenxiang Zhu, Xiangjun Yin, Zhen Wei, Wenjie Song, Qingguo Wang
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) represents one of the most common forms of liver disease worldwide, and it is always regarded as a consequence of a sedentary, food-abundant lifestyle, sitting for an extended time, and a low physical activity level, which often coincide with chronic and long-lasting psychological stress. A Chinese medicine Sinisan (SNS) may be a potential formula for treating this kind of disease. METHODS: In this study, a long-term chronic restraint stress protocol was used to investigate the mechanism underlying stress-induced NALFD...
April 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28385385/deactivating-fatty-acids-acyl-coa-thioesterase-mediated-control-of-lipid-metabolism
#16
REVIEW
Veronika Tillander, Stefan E H Alexson, David E Cohen
The cellular uptake of free fatty acids (FFA) is followed by esterification to coenzyme A (CoA), generating fatty acyl-CoAs that are substrates for oxidation or incorporation into complex lipids. Acyl-CoA thioesterases (ACOTs) constitute a family of enzymes that hydrolyze fatty acyl-CoAs to form FFA and CoA. Although biochemically and biophysically well characterized, the metabolic functions of these enzymes remain incompletely understood. Existing evidence suggests regulatory roles in controlling rates of peroxisomal and mitochondrial fatty acyl-CoA oxidation, as well as in the subcellular trafficking of fatty acids...
April 3, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28384903/a-rare-case-of-unilateral-acute-idiopathic-maculopathy-in-young-male
#17
Atul Kumar Singh, Vikas Sharma
Unilateral Acute Idiopathic Maculopathy (UAIM) is a rare disorder of Retinal Pigmentary Epithelium (RPE) that mainly affects the young healthy male. The variability of this disease can masquerade different entity, so diagnosis becomes cumbersome. We are reporting a case of young healthy male, who has reported to us with gross diminution of vision from right eye. Right eye examination showed a grayish yellow lesion with fluffy margins on the macula. Based on Optical Coherence Tomography (OCT) and Fundus Fluorescein Angiography (FFA) findings, he was diagnosed as a case of UAIM...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28381770/a-new-strategy-to-refine-crude-indian-sardine-oil
#18
S Charanyaa, Prasanna D Belur, I Regupathi
Current work aims to develop a refining process for removing phospholipids, free fatty acids (FFA), and metal ions without affecting n-3 polyunsaturated fatty acid (n-3 PUFA) esters present in the crude Indian sardine oil. Sardine oil was subjected to degumming with various acids (orthophosphoric acid, acetic acid, and lactic acid), conventional and membrane assisted deacidification using various solvents (methanol, ethanol, propanol and butanol) and bleaching with bleaching agents (GAC, activated earth and bentonite) and all the process parameters were further optimized...
April 4, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28378252/intravitreal-dexamethasone-implant-for-recalcitrant-cystoid-macular-edema-secondary-to-retinitis-pigmentosa-a-pilot-study
#19
Aditya Sudhalkar, Laurent Kodjikian, Nishikant Borse
BACKGROUND: To determine the utility of the intravitreal dexamethasone implant as therapy for cystoid macular edema (CME) secondary to retinitis pigmentosa (RP) recalcitrant to carbonic anhydrase inhibitor therapy over 2 years as a pilot study. METHODS: This was a prospective case series. Patients who showed either an incomplete or no response to topical dorzolamide for at least 1 month and oral acetazolamide therapy for at least 15 days were recruited for the study with informed consent...
April 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28374992/liquid-extraction-surface-analysis-mass-spectrometry-identifies-the-presence-and-severity-of-non-alcoholic-fatty-liver-disease
#20
Zoe Hall, Yajing Chu, Julian Leether Griffin
The early stages of non-alcoholic fatty liver disease (NAFLD) are characterised by the accumulation of fat in the liver (steatosis). This can lead to cell injury and inflammation resulting in non-alcoholic steatohepatitis (NASH). To determine whether lipid profiling of liver tissue can identify metabolic signatures associated with disease presence and severity, we explored liquid extraction surface analysis-mass spectrometry (LESA-MS) as a novel sampling tool. Using LESA-MS, lipids were extracted directly from the surface of ultra-thin slices of liver tissue prior to detection by high resolution mass spectrometry (MS)...
April 4, 2017: Analytical Chemistry
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