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https://www.readbyqxmd.com/read/28738323/the-role-of-exogenous-hydrogen-sulfide-in-free-fatty-acids-induced-inflammation-in-macrophages
#1
Zhu-Lin Luo, Jian-Dong Ren, Zhu Huang, Tao Wang, Ke Xiang, Long Cheng, Li-Jun Tang
BACKGROUND: This study aimed to investigate whether exogenous hydrogen sulfide (H2S) can protect the RAW264.7 macrophages against the inflammation induced by free fatty acids (FFA) by blunting NLRP3 inflammasome activation via a specific TLR4/NF-κB pathway. METHODS: RAW264.7 macrophages were exposed to increasing concentrations of FFA for up to 3 days to induce FFA-induced inflammation. The cells were pretreated with NaHS (a donor of H2S) before exposure to FFA...
July 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28736944/short-term-acipimox-treatment-is-associated-with-decreased-cardiac-parasympathetic-modulation
#2
Esben Thyssen Vestergaard, Simon Lebech Cichosz, Niels Møller, Jens Otto Lunde Jørgensen, Jesper Fleischer
AIM: The nicotinic acid analogue acipimox is an anti-lipolytic agent, which acutely inhibits lipolysis, and suppresses systemic levels of free fatty acids (FFA) and improves insulin sensitivity in obese patients. These effects of acipimox are transient due to a counter-regulatory increase in growth hormone (GH) levels that reverse the anti-lipolytic effect of acipimox. Hypopituitary patients constitute a viable model to study the GH-independent effects of acipimox and the impact of isolated changes in FFA concentrations and insulin sensitivity on parasympathetic nervous activity...
July 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28736812/hair-transplantation-for-the-treatment-of-lichen-planopilaris-and-frontal-fibrosing-alopecia-a-report-of-two-cases
#3
You-Chen Serena Liu, Shiou-Hwa Jee, Jung-Yi Lisa Chan
The efficacy of current medical treatments for lichen planopilaris (LPP) and its variant, frontal fibrosing alopecia (FFA), both lymphocyte-mediated primary cicatricial alopecias, is limited. Hair regrowth from scar tissue is usually not possible. Although hair transplantation restores the hairline and increases hair density in patients with cicatricial alopecia, the timing of the transplantation is crucial. Here, we report two Chinese patients with LPP or FFA who underwent the follicular unit extraction method of hair transplantation after the diseases were stabilised with therapy, with satisfactory results for 3-4 years of follow up...
July 24, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28730676/evaluation-of-the-specific-effects-of-intranasal-glucagon-on-circulating-glucose-and-lipid-concentrations-in-healthy-males-during-a-pancreatic-clamp
#4
Satya Dash, Changting Xiao, Priska Stahel, Khajag Koulajian, Adria Giacca, Gary F Lewis
CONTEXT: Intravenous/intramuscular glucagon stimulates hepatic glucose production and adipose lipolysis. Intranasal glucagon (ING) has recently been shown to be an effective treatment for hypoglycaemia. Intranasal administration of hormones increases its central nervous system (CNS) concentration with metabolic effects independent of its plasma concentration, potentially via CNS action. Whether ING has metabolic effects independent of plasma glucagon is unknown. OBJECTIVE: To investigate the specific effects of intranasal glucagon (ING) on plasma glucose, endogenous glucose production (EGP) and lipid concentration...
July 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28729703/the-basal-free-fatty-acid-concentration-in-human-saliva-is-related-to-salivary-lipolytic-activity
#5
Eric Neyraud, Stéphanie Cabaret, Hélène Brignot, Claire Chabanet, Hélène Labouré, Elisabeth Guichard, Olivier Berdeaux
Fat perception during eating is a complex sensation that involves various sensory modalities, such as texture, aroma and taste. Taste is supported by the discovery of fatty acid receptors in the tongue papillae. Dietary fat is mainly composed of esterified fatty acids, whereas only free fatty acids can bind to taste receptors. Some authors have mentioned the necessity and efficiency of salivary lipolytic activity to hydrolyse the esterified fatty acids present in foods and enable fat perception. Our hypothesis is that salivary lipolytic activity is also involved in regulating the basal level of salivary fatty acids in humans...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28728183/early-focal-laser-photocoagulation-in-acute-central-serous-chorioretinopathy-a-prospective-randomized-study
#6
Vikas Ambiya, Mitali Khodani, Abhilash Goud, Raja Narayanan, Mudit Tyagi, Padmaja Kumari Rani, Jay Chhablani
BACKGROUND AND OBJECTIVE: To evaluate the role of early focal laser photocoagulation in acute central serous chorioretinopathy (CSC). PATIENTS AND METHODS: A total of 58 eyes with acute naïve CSC (less than 2 months' duration) with focal leak on fundus fluorescein angiography (FFA) were randomized into either a laser or a sham laser group. Eyes with chronic CSC and subfoveal leak were excluded. Visual acuity assessment, microperimetry, optical coherence tomography, and FFA were done at baseline, 1 month (minus FFA), 3 months, and 6 months after treatment...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28728097/nonlinear-modulation-of-interacting-between-comt-and-depression-on-brain-function
#7
L Gong, C He, Y Yin, Q Ye, F Bai, Y Yuan, H Zhang, L Lv, H Zhang, Z Zhang, C Xie
BACKGROUND: The catechol-O-methyltransferase (COMT) gene is related to dopamine degradation and has been suggested to be involved in the pathogenesis of major depressive disorder (MDD). However, how this gene affects brain function properties in MDD is still unclear. METHODS: Fifty patients with MDD and 35 cognitively normal participants underwent a resting-state functional magnetic resonance imaging scan. A voxelwise and data-drive global functional connectivity density (gFCD) analysis was used to investigate the main effects and the interactions of disease states and COMT rs4680 gene polymorphism on brain function...
June 9, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28727235/thermal-imaging-and-dermoscopy-for-detecting-inflammation-in-frontal-fibrosing-alopecia
#8
Anna Lis-Święty, Bartosz Miziołek, Irmina Ranosz-Janicka, Grażyna Bierzyńska-Macyszyn, Ligia Brzezińska-Wcisło
BACKGROUND: Frontal fibrosing alopecia (FFA) is an inflammatory condition of the scalp, which leads to scarring and slowly progressive recession of frontotemporal and/or frontoparietal hairline. Choice of FFA treatment is highly dependent on accurate assessment of disease phase, as medical treatments are effective only during the initial inflammatory stage. METHODS: To objectively quantify the activity of the inflammatory process in FFA, 22 female patients were examined by both infrared thermography and optical dermoscopy before tissue sampling...
July 20, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28726347/md2-blockage-protects-obesity-induced-vascular-remodeling-via-activating-ampk-nrf2
#9
Lintao Wang, Jibo Han, Peiren Shan, Shengban You, Xuemei Chen, Yiyi Jin, Jingying Wang, Weijian Huang, Yi Wang, Guang Liang
OBJECTIVE: Obesity and increased free fatty acid (FFA) levels are tightly linked with vascular oxidative stress and remodeling. Myeloid differentiation 2 (MD2), an important protein in innate immunity, is requisite for endotoxin lipopolysaccharide responsiveness. This study shows that palmitic acid (PA) also bonds to MD2, initiating cardiac inflammatory injury. However, it is not clear whether MD2 plays a role in noninflammatory systems such as obesity- and FFA-related oxidative stress involved in vascular remodeling and injury...
July 20, 2017: Obesity
https://www.readbyqxmd.com/read/28722810/impact-of-crude-oil-quality-on-the-refining-conditions-and-composition-of-nutraceuticals-in-refined-palm-oil
#10
Klicia A Sampaio, Jose Vila Ayala, Vera Van Hoed, Simone Monteiro, Roberta Ceriani, Roland Verhé, Antonio J A Meirelles
Palm oil is the major vegetable oil used worldwide due to its unique properties. The effect of crude palm oil acidity on the final free fatty acids (FFA) content, neutral oil loss (NOL), and nutraceutical compounds, such as carotenes, total tocols (tocopherols and tocotrienols), squalene, and phytosterols was investigated. A central composite design was employed to study the influence of the refining conditions: temperature (200 to 260 °C), steam percentage (0.5% to 3.5%), and initial FFA content (2.2% to 6...
July 19, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28720930/changes-in-oxidation-indices-and-minor-components-of-low-free-fatty-acid-and-freshly-extracted-crude-palm-oils-under-two-different-storage-conditions
#11
Choon-Hui Tan, Abdul A Ariffin, Hasanah M Ghazali, Chin-Ping Tan, Ainie Kuntom, Adrian Cheng-Yong Choo
This article reports on the changes of oxidation indices and minor components of low free fatty acid (FFA) and freshly extracted crude palm oils after storage at ambient (28 ± 1 C) and 60 C for 77 days. The changes in peroxide value (PV), FFA, extinction coefficient at 233 and 269 nm (K233 and K269), bleachability index (DOBI), carotene and vitamin E contents were monitored. PV, FFA, K233 and K269 of both oil samples increased as storage progressed while the values of carotene and vitamin E contents decreased...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28716436/frontal-fibrosing-alopecia-among-men-a%C3%A2-clinicopathologic-study-of-7-cases
#12
Stanislav N Tolkachjov, Hafsa M Chaudhry, Michael J Camilleri, Rochelle R Torgerson
BACKGROUND: Frontal fibrosing alopecia (FFA) is a lichen planopilaris-variant scarring alopecia that has rarely been described in men. OBJECTIVE: To characterize the clinicopathologic findings of FFA in men by studying a series of 7 male patients. METHODS: We conducted a retrospective review of all cases of male patients with FFA at the Mayo Clinic from 1992 to 2016. RESULTS: Seven male patients with FFA were identified...
July 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28715812/free-fatty-acid-is-associated-with-thrombogenicity-in-cardioembolic-stroke
#13
Woo-Keun Seo, Jin-Man Jung, Ji Hyun Kim, Seong-Beom Koh, Oh Young Bang, Kyungmi Oh
BACKGROUND: Recently, the role of free fatty acids (FFAs) in thromboembolism has re-emerged in the context of cardioembolic stroke. Therefore, we attempted to determine the role of FFAs in embolic risk in various potential sources of cardioembolism (PSCE). We hypothesized that if elevated FFA levels in stroke patients are associated with thrombogenesis, then patients with a well-known high risk of embolic sources would have high FFA levels. METHODS: Data collected from 2 hospital-based stroke registries were analyzed to investigate the association between FFA and PSCE...
July 18, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28713246/differential-contribution-of-ca-2-dependent-mechanisms-to-hyperexcitability-in-layer-v-neurons-of-the-medial-entorhinal-cortex
#14
Eric C Lin, Crescent L Combe, Sonia Gasparini
Temporal lobe epilepsy is characterized by recurrent seizures in one or both temporal lobes of the brain; some in vitro models show that epileptiform discharges initiate in entorhinal layer V neurons and then spread into other areas of the temporal lobe. We previously found that, in the presence of GABAA receptor antagonists, stimulation of afferent fibers, terminating both at proximal and distal dendritic locations, initiated hyperexcitable bursts in layer V medial entorhinal neurons. We investigated the differential contribution of Ca(2+)-dependent mechanisms to the plateaus underlying these bursts at proximal and distal synapses...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28711708/ezetimibe-and-simvastatin-combination-inhibits-and-reverses-the-pro-inflammatory-and-pro-atherogenic-effects-of-cream-in-obese-patients
#15
Husam Ghanim, Kelly Green, Sanaa Abuaysheh, Reema Patel, Manav Batra, Ajay Chaudhuri, Antoine Makdissi, Nitesh D Kuhadiya, Paresh Dandona
BACKGROUND AND AIMS: Inflammation and postprandial lipemia are associated with increased cardiovascular disease. We investigated whether ezetimibe and simvastatin combination, a lipid lowering combination of simvastatin and ezetimibe, exerts an anti-inflammatory effect in the fasting state and after dairy cream intake. METHODS: Twenty obese patients were randomized to either ezetimibe and simvastatin combination or placebo treatment for 6 weeks. All patients were asked to ingest 33 ml of dairy cream (300 Calories) at the beginning and at the end of intervention...
June 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28711265/feeding-a-concentrate-rich-in-rapeseed-oil-improves-fatty-acid-composition-and-flavor-in-norwegian-goat-milk
#16
R A Inglingstad, S Skeie, G E Vegarud, T G Devold, Y Chilliard, M Eknæs
Impaired quality due to a high content of free fatty acids (FFA) and off-flavors has caused challenges in the development of Norwegian goat milk products. The present study aimed to examine the effect of lipid-supplemented concentrates on milk fat content, fatty acid composition, FFA, lipoprotein lipase activity, sensory properties, and size of milk fat globules of goat milk. Thirty goats assigned to 3 experimental groups were fed different concentrates from 60 d in milk (DIM) until late lactation (230 DIM)...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28704726/bnip3-induction-by-hypoxia-stimulates-fasn-dependent-free-fatty-acid-production-enhancing-therapeutic-potential-of-umbilical-cord-blood-derived-human-mesenchymal-stem-cells
#17
Hyun Jik Lee, Young Hyun Jung, Gee Euhn Choi, So Hee Ko, Sei-Jung Lee, Sang Hun Lee, Ho Jae Han
Mitophagy under hypoxia is an important factor for maintaining and regulating stem cell functions. We previously demonstrated that fatty acid synthase (FASN) induced by hypoxia is a critical lipid metabolic factor determining the therapeutic efficacy of umbilical cord blood-derived human mesenchymal stem cells (UCB-hMSCs). Therefore, we investigated the mechanism of a major mitophagy regulator controlling lipid metabolism and therapeutic potential of UCB-hMSCs. This study revealed that Bcl2/adenovirus E1B 19kDa protein-interacting protein 3 (BNIP3)-dependent mitophagy is important for reducing mitochondrial reactive oxygen species accumulation, anti-apoptosis, and migration under hypoxia...
July 4, 2017: Redox Biology
https://www.readbyqxmd.com/read/28704507/regular-moist-snuff-dipping-does-not-affect-endurance-exercise-performance
#18
Frida Björkman, Fredrik Edin, C Mikael Mattsson, Filip Larsen, Björn Ekblom
Physiological and medical effects of snuff have previously been obtained either in cross-sectional studies or after snuff administration to non-tobacco users. The effects of snuff cessation after several years of daily use are unknown. 24 participants with >2 years of daily snuff-use were tested before and after >6 weeks snuff cessation (SCG). A control group (CO) of 11 snuff users kept their normal habits. Resting heart rate (HR) and blood pressure (BP) were significantly lower in SCG after snuff cessation, and body mass was increased by 1...
2017: PloS One
https://www.readbyqxmd.com/read/28696468/the-effect-of-probe-choice-and-solution-conditions-on-the-apparent-photoreactivity-of-dissolved-organic-matter
#19
Andrew C Maizel, Christina K Remucal
Excited triplet states of dissolved organic matter ((3)DOM) are quantified directly with the species-specific probes trans,trans-hexadienoic acid (HDA) and 2,4,6-trimethylphenol (TMP), and indirectly with the singlet oxygen ((1)O2) probe furfuryl alcohol (FFA). Although previous work suggests that these probe compounds may be sensitive to solution conditions, including dissolved organic carbon concentration ([DOC]) and pH, and may quantify different (3)DOM subpopulations, the probes have not been systematically compared...
July 11, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28693693/can-fundus-fluorescein-angiography-be-performed-for-diabetic-patients-on-oral-metformin-%C3%A2
#20
Du Junhui, Li Rong
Metformin is a kind of biguanide hypoglycemic agent that has been widely used in patients with diabetes mellitus. In clinical practice, whether metformin should be stopped before Fundus fluorescein angiography (FFA) remains largely unclear. Some endocrinologists suggest stop metformin before FFA. However, ophthalmologists do not always adopt this opinion in their practice. This situation may lead to disputes between physicians and patients. This article analyzed contrast-induced nephropathy(CIN) and the related contrast agent, as well as the adverse reactions of fluorescein angiography...
June 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
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