keyword
MENU ▼
Read by QxMD icon Read
search

Tongue cancer

keyword
https://www.readbyqxmd.com/read/28739712/total-glossectomy-without-laryngectomy-for-advanced-squamous-cell-cancer-of-the-tongue-functional-and-oncological-results
#1
Maximilian Reiter, Ulrich Harréus
BACKGROUND/AIM: Total glossectomy without laryngectomy for large tongue carcinomas still remains controversial, as these defects may go along with dramatic effects on respiration, speech and swallowing. As a consequence, these procedures significantly impact quality of life. Therefore, larger case series are rare. Nevertheless, with the development of free tissue transfer, functional reconstruction has become increasingly popular and encouraging results are reported in the literature...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28722333/xiap-inhibitor-embelin-induces-autophagic-and-apoptotic-cell-death-in-human-oral-squamous-cell-carcinoma-cells
#2
You-Jin Lee, Bong-Soo Park, Hae-Ryoun Park, Su-Bin Yu, Hae-Mi Kang, In-Ryoung Kim
Embelin is an active ingredient of traditional herbal remedies for cancer and other diseases. Recently, it has been suggested that autophagy may play an important role in cancer therapy. However, little data are available regarding the role of autophagy in oral cancers. Therefore, we conducted this study to examine whether Embelin modulates autophagy in Ca9-22. Our results showed that Embelin had anticancer activity against the Ca9-22 human tongue squamous cell, and we observed that autophagic vacuoles were formed by MDC and AO...
July 19, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28722004/oral-gingival-metastasis-a-diagnostic-dilemma
#3
Nalini Aswath, Chandrakanth Balakrishnan, Vidyarani Shyamsundar, Sarumathi Thirrugnanamurthy
Oral cavity is a rare target for metastasis with an incidence of 1% among all oral cancers. In 24% of such cases, oral metastasis is the first indication of an undiagnosed primary. Metastatic oral malignancies have been reported in the mandible, tongue, and gingiva. Although gingival metastasis has been reported from lung, prostate, rectal carcinoma in men and carcinoma of breast, adrenal glands, and genitalia in females, gingival metastasis from carcinoma of the penis has not been reported. Herein, a case of metastatic gingival carcinoma that developed after extraction of teeth from primary carcinoma of the penis is presented...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28720161/validity-of-the-american-college-of-surgeons-national-surgical-quality-improvement-program-risk-calculator-in-south-australian-glossectomy-patients
#4
S S Kao, C Frauenfelder, D Wong, S Edwards, S Krishnan, E H Ooi
BACKGROUND: Appropriate selection of tongue cancer patients considering surgery is critical in ensuring optimal outcomes. The American College of Surgeons' National Surgical Quality Improvement Program ('ACS-NSQIP') risk calculator was developed to assess patients' 30-day post-operative risk, providing surgeons with information to guide decision making. METHOD: A retrospective review of 30-day actual mortality and morbidity of tongue cancer patients was undertaken to investigate the validity of this tool for South Australian patients treated from 2005 to 2015...
July 19, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28718033/a-new-clinical-trial-of-neoadjuvant-chemotherapy-combined-with-transoral-robotic-surgery-and-customized-adjuvant-therapy-for-patients-with-t3-or-t4-oropharyngeal-cancer
#5
Young Min Park, Chan Min Jung, Dongchul Cha, Da Hee Kim, Hye Ryun Kim, Ki Chang Keum, Nam Hoon Cho, Se-Heon Kim
BACKGROUND: A prospective clinical trial of combination neoadjuvant chemotherapy, transoral robotic surgery (TORS), and customized adjuvant therapy for patients with locally advanced oropharyngeal cancer was conducted. METHODS: Between July 2009 and October 2016, 31 patients were enrolled in this clinical trial. RESULTS: The primary lesions were located in the tonsils of 27 patients and in the base of the tongue of 4 patients. Of the 31 patients, 16 (51...
July 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28717287/cervical-metastases-behavior-of-t1-2-squamous-cell-carcinoma-of-the-tongue
#6
K Sagheb, V Kumar, R Rahimi-Nedjat, M Dollhausen, T Ziebart, B Al-Nawas, C Walter
INTRODUCTION: The cervical lymph node metastasis (CM) is one of the most important prognostic factors for oral squamous cell carcinoma. Although the frequency and distribution of CM for tongue carcinoma (TC) are well documented in the literature, there is only little data on metastasis patterns depending on the location of the cancer within the tongue. MATERIALS AND METHODS: In a retrospective study all patients with a T1-T2 TC who were treated between 1997 and 2013 were analysed regarding epidemiological data, risk factors, and tumour parameters such as exact localization, CM...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28700659/expression-levels-of-cleaved-caspase-3-and-caspase-3-in-tumorigenesis-and-prognosis-of-oral-tongue-squamous-cell-carcinoma
#7
Pei-Feng Liu, Yu-Chang Hu, Bor-Hwang Kang, Yu-Kai Tseng, Pi-Chuang Wu, Chi-Chuang Liang, Yu-Yi Hou, Ting-Ying Fu, Huei-Han Liou, I-Chien Hsieh, Luo-Ping Ger, Chih-Wen Shu
Apoptosis plays a dual role in cancer development and malignancy. The role of apoptosis-related caspases in cancer remains controversial, particularly in oral tongue squamous cell carcinoma (OTSCC). In this study, we examined the protein levels of cleaved caspase-3, caspase-3, caspase-8, and caspase-9 on tissue microarrays consisting of samples from 246 OTSCC patients by immunohistochemistry. Wilcoxon signed-rank test indicated that the protein levels of cleaved caspase-3, caspase-3, caspase-8, and caspase-9 in tumor tissues were significantly higher compared to those in adjacent normal tissues (all p<0...
2017: PloS One
https://www.readbyqxmd.com/read/28700336/gene-expression-profiling-to-predict-recurrence-of-advanced-squamous-cell-carcinoma-of-the-tongue-discovery-and-external-validation
#8
Tomohiro Enokida, Satoshi Fujii, Mari Takahashi, Youichi Higuchi, Shogo Nomura, Tetsuro Wakasugi, Tomoko Yamazaki, Ryuichi Hayashi, Atsushi Ohtsu, Makoto Tahara
OBJECTIVES: To establish a prognostic signature for locally advanced tongue squamous cell carcinoma (TSCC) patients treated with surgery. RESULTS: In the discovery study, unsupervised hierarchical clustering analysis identified two clusters which differentiated the Kaplan-Meier curves of RFS [median RFS, 111 days vs. not reached; log-rank test, P = 0.023]. The 30 genes identified were combined into a dichotomous PI. In the validation cohort, classification according to the PI was associated with RFS [median RFS, 754 days vs...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28697656/impact-of-liver-transplantation-on-the-risk-of-second-malignant-tumors-among-hepatocellular-carcinoma-patients
#9
Hani Oweira, Jan Schmidt, Daniel Helbling, Ulf Petrausch, Othmar Schöb, Arianeb Mehrabi, Anwar Giryes, Hazem Elhadedy, Omar Abdel-Rahman
BACKGROUND: Population-based data on the development of second malignant neoplasms (SMNs) following the diagnosis of hepatocellular carcinoma (HCC) are uncommon. We evaluated this clinical vignette in HCC patients within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database (1973-2012) was queried using the SEER*Stat program to determine the clinico-pathological features of HCC patients with more than one year survival who developed SMNs...
July 12, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28693162/kikuchi-fujimoto-disease-in-the-regional-lymph-nodes-with-node-metastasis-in-a-patient-with-tongue-cancer-a-case-report-and-literature-review
#10
Tessho Maruyama, Kazuhide Nishihara, Masanao Saio, Toshiyuki Nakasone, Fumikazu Nimura, Akira Matayoshi, Takahiro Goto, Naoki Yoshimi, Akira Arasaki
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare self-limiting disorder typically affecting the cervical lymph nodes (LNs), which is often misdiagnosed as other LN-associated diseases. KFD frequently presents with necrotic lesions and recurrences, which are also features of metastatic LNs. Clinicians may thus suspect LN metastasis when they encounter ipsilateral cervical lymphadenopathy in a patient with head and neck cancer. The present study reports the case of a 48-year-old man with tongue cancer and KFD affecting the right edge of his tongue and ipsilateral cervical LNs...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693152/multicenter-research-into-the-quality-of-life-of-patients-with-advanced-oropharyngeal-carcinoma-with-long-term-survival-associated-with-human-papilloma-virus
#11
Giacomo Spinato, Marco Stellin, Giuseppe Azzarello, Deborah Bonazza, Fabrizio Zanconati, Doriano Politi, Salvatore Cocuzza, Paola Di Mauro, Simonetta Ausoni, Giovanni Tonoli, Giulio Costantini, Luigi Maiolino, Roberto Spinato, Maria Cristina Da Mosto, Lorena Baboci, Annarosa Del Mistro, Agostino Serra, Giancarlo Tirelli
The treatment of advanced-stage oropharyngeal squamous cell carcinoma may utilize various modes, including combining surgery with chemoradiotherapy (CTRT), or primary CTRT followed by rescue surgery. In previous literature it has been revealed how patients treated with combined modes report a low quality of life (QoL) and severe consequences following surgery, radiotherapy and chemotherapy, in the short and in the long-term. The decrease in the QoL of patients treated with high-intensity multi-modal strategies highlights the necessity of modifying treatments, particularly for young HPV-positive patients, where an increased survival rate has already been reported...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28686556/effects-of-radon-and-uv-exposure-on-skin-cancer-mortality-in-switzerland
#12
Danielle Vienneau, Kees de Hoogh, Dimitri Hauri, Ana M Vicedo-Cabrera, Christian Schindler, Anke Huss, Martin Röösli
BACKGROUND: Skin cancer incidence in Switzerland is among the highest in the world. In addition to exposure to ultraviolet (UV) radiation, radon alpha particles attached to aerosols can adhere to the skin and potentially cause carcinogenic effects. OBJECTIVES: We investigated the effects of radon and UV exposure on skin cancer mortality. METHODS: Cox proportional hazard regression was used to study the association between exposures and skin cancer mortality in adults from the Swiss National Cohort...
June 16, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28683823/sema3a-drastically-suppresses-tumor-growth-in-oral-cancer-xenograft-model-of-mice
#13
Chao Huang, Yi Wang, Jian-Hua Huang, Weixian Liu
BACKGROUND: Multiple studies suggest anti-angiogenesis to be a promising and rational option in cancer treatment. Interestingly, the axonal sprouting inhibitor semaphorin 3A (Sema3A), a potent suppressor of tumor angiogenesis in various cancer models, is lowly expressed in human oral cancer. Thus, we hypothesized that overexpression of Sema3A in human oral cancer cells may have potential therapeutic effects. METHODS: The LentiSema3A-EGFP was first constructed and transduced to the tongue squamous cell carcinoma cell line SSC-9...
July 6, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28683301/-deep-extrinsic-muscle-involvement-is-a-fallacy-in-the-american-joint-committee-on-cancer-s-seventh-edition-of-tumor-staging-of-oral-cavity-cancers
#14
Samskruthi P Murthy, Krishnakumar Thankappan, Sandya Chirukandath Jayasankaran, Karippaliyil Milind, Chaya Prasad, Deepak Balasubramanian, Subramania Iyer
PURPOSE: The seventh edition of tumor staging by the American Joint Committee on Cancer (AJCC) includes extrinsic muscle involvement to define stage T4a tongue carcinomas. The anatomic location of extrinsic muscles predisposes them to early involvement even in superficial tumors. The purpose of this study was to expose a fallacy in this staging system for extrinsic muscle involvement. MATERIALS AND METHODS: This was a prospective cohort study of 87 patients with oral tongue squamous cell carcinoma...
June 10, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28679776/phase-i-trial-of-intravenous-oncolytic-vaccinia-virus-gl-onc1-with-cisplatin-and-radiotherapy-in-patients-with-locoregionally-advanced-head-and-neck-carcinoma
#15
Loren K Mell, Kevin T Brumund, Gregory A Daniels, Sunil J Advani, Kaveh Zakeri, Mary E Wright, Sara-Jane Onyeama, Robert A Weisman, Parag R Sanghvi, Peter J Martin, Aladar A Szalay
Pre-clinical models have shown that the effectiveness of GL-ONC1, a modified <p>oncolytic vaccinia virus, is enhanced by radiation and chemotherapy. The purpose of this study</p> <p>was to determine the safety of GL-ONC1 when delivered intravenously with chemoradiotherapy</p> <p>to patients with primary, non-metastatic head and neck cancer.</p> <p>EXPERIMENTAL DESIGN: Patients with locoregionally advanced unresected, non-metastatic</p> <p>carcinoma of the head/neck, excluding stage III-IVA p16-positive oropharyngeal cancers, were</p> <p>treated with escalating doses and cycles of intravenous GL-ONC1, along with radiotherapy and</p> <p>chemotherapy...
July 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28679629/evaluation-of-ethyl-gallate-for-its-antioxidant-and-anticancer-property-against-chemical-induced-tongue-carcinogenesis-in-mice
#16
Shalini Mohan, Kalaivani Thiagarajan, Rajasekaran Chandrasekaran
Cancer raised in the oral cavity is one of the major causes of mortality worldwide and demand immediate attention. Regardless of the use of advanced treatment for oral cancer, successful treatment with cancer survival is less. Currently available drugs are though effective against cancer, treatment without toxic effects remains essential. This is quiet challenging leading to the identification of natural bioactive compounds for oral cancer treatment. Thus, a plant extract rich in phenolics was preferred to study the cellular, biochemical and molecular changes associated with oral carcinogenesis...
July 5, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28673713/alterations-in-opioid-inhibition-cause-widespread-nociception-but-do-not-affect-anxiety-like-behavior-in-oral-cancer-mice
#17
Yi Ye, Daniel G Bernabé, Elizabeth Salvo, Chi T Viet, Kentaro Ono, John C Dolan, Malvin Janal, Brad E Aouizerat, Christine Miaskowski, Brian L Schmidt
Widespread pain and anxiety are commonly reported in cancer patients. We hypothesize that cancer is accompanied by attenuation of endogenous opioid-mediated inhibition, which subsequently causes widespread pain and anxiety. To test this hypothesis we used a mouse model of oral squamous cell carcinoma (SCC) in the tongue. We found that mice with tongue SCC exhibited widespread nociceptive behaviors in addition to behaviors associated with local nociception that we reported previously. Tongue SCC mice exhibited a pattern of reduced opioid receptor expression in the spinal cord; intrathecal administration of respective mu (MOR), delta (DOR), and kappa (KOR) opioid receptor agonists reduced widespread nociception in mice, except for the fail flick assay following administration of the MOR agonist...
June 30, 2017: Neuroscience
https://www.readbyqxmd.com/read/28669249/human-papillomavirus-and-p16-protein-expression-as-prognostic-biomarkers-in-mobile-tongue-cancer
#18
Kazuhiko Minami, Yasunao Kogashiwa, Yasuhiro Ebihara, Mitsuhiko Nakahira, Masashi Sugasawa, Takashi Fujino, Masanori Yasuda
OBJECTIVES: The objectives were to determine the prevalence of human papillomavirus (HPV) in mobile tongue cancer (MTC) and evaluate associations and survival. MATERIALS AND METHODS: Patients who underwent surgical resection as primary treatment for MTC (n = 127) were retrospectively evaluated. Formalin-fixed paraffin-embedded (FFPE) specimens were assessed for p16 and p53 by immunohistochemistry; for HPV DNA by nested multiplex polymerase chain reaction (PCR) using two pairs of consensus primers (MY09-MY11 and GP5+-GP6+); and for E6 and E7 oncogenes from 13 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 52, 56, 58, 59, 66, and 68) by real-time reverse transcription PCR (RT-PCR)...
July 2, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28666190/chemotherapy-induces-oral-mucositis-in-mice-without-additional-noxious-stimuli
#19
M Bertolini, T Sobue, A Thompson, A Dongari-Bagtzoglou
Oral mucositis (OM) is a serious side effect of cancer chemotherapy. The pathobiology of oral mucositis remains incompletely understood due to lack of appropriate models which recapitulate the human condition. Existing rodent models are intraperitoneal and require radiation, chemical or mechanical injury to the chemotherapy protocol to induce oral lesions. We aimed to develop an OM mouse model that is induced solely by chemotherapy and reproduces macroscopic, histopathologic and inflammatory characteristics of the human condition...
June 27, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28662643/e3-ubiquitin-ligase-rnf139-inhibits-the-progression-of-tongue-cancer
#20
Lina Wang, Wei Yin, Chun Shi
BACKGROUND: Tongue cancer is still one of the leading causes of mortality around the world. Recently, the ubiquitin system has been established as a critical modulator of tumors. In order to find the oral cancer related E3 ubiquitin ligases, we screened the human E3 ubiquitin ligase library and found that RING finger protein 139 (RNF139) regulated the biological behavior of tongue cancer cells. METHODS: MTT assay was used to analyze the cell viability changes of tongue cancer SCC9 and SCC25 cells caused by RNF139...
June 29, 2017: BMC Cancer
keyword
keyword
54180
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"