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Tongue cancer

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https://www.readbyqxmd.com/read/28921845/detection-and-delineation-of-squamous-neoplasia-with-hyperspectral-imaging-in-a-mouse-model-of-tongue-carcinogenesis
#1
Guolan Lu, Dongsheng Wang, Xulei Qin, Susan Muller, Xu Wang, Amy Y Chen, Zhuo Georgia Chen, Baowei Fei
yperspectral imaging (HSI) holds the potential for the noninvasive detection of cancers. Oral cancers are often diagnosed at a late stage when treatment is less effective and the mortality and morbidity rates are high. Early detection of oral cancer is, therefore, crucial in order to improve the clinical outcomes. To investigate the potential of HSI as a non-invasive diagnostic tool, an animal study was designed to acquire hyperspectral images of in vivo and ex vivo mouse tongues from a chemically induced tongue carcinogenesis model...
September 17, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28905102/digestive-system-in-psoriasis-an-update
#2
REVIEW
Daniel Pietrzak, Aldona Pietrzak, Dorota Krasowska, Andrzej Borzęcki, Kinga Franciszkiewicz-Pietrzak, Beata Polkowska-Pruszyńska, Maja Baranowska, Kristian Reich
Psoriasis is a chronic inflammatory immune-mediated disorder associated and often coexisting with many other immune-related clinical conditions including those affecting the gastrointestinal tract. Data obtained from the reviewed literature suggest an association between psoriasis and pathologies of the oral cavity, both psoriasis-specific lesions, as well as non-specific, such as geographic tongue or fissured tongue. These findings show the importance of thorough examination of oral mucosa in psoriatic patients...
September 13, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28904972/evaluation-of-the-bacterial-diversity-in-the-human-tongue-coating-based-on-genus-specific-primers-for-16s-rrna-sequencing
#3
Beili Sun, Dongrui Zhou, Jing Tu, Zuhong Lu
The characteristics of tongue coating are very important symbols for disease diagnosis in traditional Chinese medicine (TCM) theory. As a habitat of oral microbiota, bacteria on the tongue dorsum have been proved to be the cause of many oral diseases. The high-throughput next-generation sequencing (NGS) platforms have been widely applied in the analysis of bacterial 16S rRNA gene. We developed a methodology based on genus-specific multiprimer amplification and ligation-based sequencing for microbiota analysis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28901471/cxc-chemokine%C3%A2-7-inhibits-growth-and-migration-of-oral-tongue-squamous-cell-carcinoma-cells-mediated-by-the-epithelial%C3%A2-mesenchymal-transition-signaling-pathway
#4
Tong-Jun Liu, Jian-Lian Guo, Xin Xu
Oral tongue squamous cell carcinoma (OTSCC) is the most common oral malignancy with different histopathological symptoms and etiology of tumorigenesis. Migration and invasion is the most important characteristics of OTSCC, and limits tumor therapy in clinics. The epithelial‑to‑mesenchymal transition (EMT) signaling pathway is an important process in the progress of tumor cell migration and invasion. Previous studies have indicated that C‑X‑C chemokine receptor‑7 (CXCR‑7) promotes the progression and metastasis of tumor cells, presenting a potential target molecule for cancer therapy...
September 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28901451/genomic-profile-of-oral-squamous-cell-carcinomas-with-an-adjacent-leukoplakia-or-with-an-erythroleukoplakia-that-evolved-after-the-treatment-of-primary-tumor-a-report-of-two-cases
#5
Ilda P Ribeiro, Francisco Marques, Leonor Barroso, Joana Rodrigues, Francisco Caramelo, Joana B Melo, Isabel M Carreira
Oral leukoplakia and erythroleukoplakia are common oral potentially malignant disorders diagnosed in the oral cavity. The specific outcome of these lesions remains to be elucidated, as their malignant transformation rate exhibits great variation. The ability to predict which of those potentially malignant lesions are likely to progress to cancer would be vital to guide their future clinical management. The present study reported two patients with tongue squamous cell carcinoma: Case study 1 was diagnosed with a simultaneous leukoplakia and case study 2 developed an erythroleukoplakia following the primary tumor treatment...
September 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900608/comparative-analysis-of-microrna-expression-among-benign-and-malignant-tongue-tissue-and-plasma-of-patients-with-tongue-cancer
#6
Guilherme Rabinowits, Michaela Bowden, Ludmila M Flores, Sigitas Verselis, Victoria Vergara, Vickie Y Jo, Nicole Chau, Jochen Lorch, Peter S Hammerman, Tom Thomas, Laura A Goguen, Donald Annino, Jonathan D Schoenfeld, Danielle N Margalit, Roy B Tishler, Robert I Haddad
BACKGROUND: Identification of a microRNA (miRNA) pattern to be used as a biomarker for HNSCC is challenging given the heterogeneity of the disease and different methodologies used. To better define the field, we performed a prospective analysis of blood, tumor, and paired benign tissues in tongue squamous cell carcinoma (SCC) patients. METHODS: Plasma samples were collected prior to surgery, and paired tumor and benign tissue blocks were collected from tongue cancer resections...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28893047/an-intervention-airing-the-effect-of-iranian-propolis-on-epithelial-dysplasia-of-the-tongue-a-preliminary-study
#7
Maedeh Salehi, Mina Motallebnejad, Ali Akbar Moghadamnia, Maryam Seyemajidi, Simin Noori Khanghah, Alireza Ebrahimpour, Tahereh Molania
INTRODUCTION: Since oral cancer is one of the causes of mortality, the use of materials or methods that can reduce cancer or prevent its progression has particular importance. AIM: Aim of the study was to evaluate the antitumor effects of Iranian propolis on dysplastic changes of oral mucosa in rats. MATERIALS AND METHODS: This study was performed on 28 Wistar male rats (aged 7-11 weeks, 160±20 g). They were divided into four groups of seven rats...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891406/clinical-practice-guideline-evaluation-of-the-neck-mass-in-adults
#8
Melissa A Pynnonen, M Boyd Gillespie, Benjamin Roman, Richard M Rosenfeld, David E Tunkel, Laura Bontempo, Itzhak Brook, Davoren Ann Chick, Maria Colandrea, Sandra A Finestone, Jason C Fowler, Christopher C Griffith, Zeb Henson, Corinna Levine, Vikas Mehta, Andrew Salama, Joseph Scharpf, Deborah R Shatzkes, Wendy B Stern, Jay S Youngerman, Maureen D Corrigan
Objective Neck masses are common in adults, but often the underlying etiology is not easily identifiable. While infections cause most of the neck masses in children, most persistent neck masses in adults are neoplasms. Malignant neoplasms far exceed any other etiology of adult neck mass. Importantly, an asymptomatic neck mass may be the initial or only clinically apparent manifestation of head and neck cancer, such as squamous cell carcinoma (HNSCC), lymphoma, thyroid, or salivary gland cancer. Evidence suggests that a neck mass in the adult patient should be considered malignant until proven otherwise...
September 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28891354/brca2-protects-mammalian-cells-from-heat-shock
#9
Yosuke Nakagawa, Atsuhisa Kajihara, Akihisa Takahashi, Akiho S Murata, Masaya Matsubayashi, Soichiro S Ito, Ichiro Ota, Takahiko Nakagawa, Masatoshi Hasegawa, Tadaaki Kirita, Takeo Ohnishi, Eiichiro Mori
PURPOSE: Heat shock induces DNA double-strand breaks (DSBs) in mammalian cells. Mammalian cells are capable of repairing DSBs by utilising the homologous recombination (HR) pathway. Breast cancer susceptibility gene 2 (BRCA2) is known to regulate the HR pathway. Here, we investigate the role of BRCA2 in repairing DNA damage induced by heat shock. MATERIALS AND METHODS: Chinese hamster lung fibroblast cell lines and human tongue squamous cell carcinoma SAS cells were used...
September 10, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28888409/maxillofacial-prosthetic-treatment-factors-affecting-oral-health-related-quality-of-life-after-surgery-for-patients-with%C3%A2-oral-cancer
#10
Miki Hagio, Ken Ishizaki, Masahiro Ryu, Takeshi Nomura, Nobuo Takano, Kaoru Sakurai
STATEMENT OF PROBLEM: After oral cancer surgery, tissue defects can cause deformity and limited mobility, complicating many essential functions. For patients with mandibular, tongue, and oral floor defects, evidence regarding the effects of maxillofacial prosthetics on their oral health-related quality of life (OHRQoL) is lacking. Therefore, maxillofacial prosthetic reconstruction has been implemented with no clear treatment goals. PURPOSE: The purpose of this study was to identify factors affecting the improvement of OHRQoL by using maxillofacial prosthetic treatment after surgery to repair maxillary, mandibular, tongue, and oral floor defects...
September 6, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28887707/correlations-between-patient-reported-dysphagia-screening-and-penetration-aspiration-scores-in-head-and-neck-cancer-patients-post-oncological-treatment
#11
Johanna Hedström, Lisa Tuomi, Caterina Finizia, Caroline Olsson
Dysphagia is a common and severe toxicity after oncological treatment of head and neck cancer (HNC). The study aim was to investigate relationships between patient-reported dysphagia and clinically measured swallowing function in HNC after modern curative radiotherapy with or without chemotherapy to identify possible alarm symptoms for clinically manifest dysphagia. Patients with tumors of the tonsil, base of tongue, hypopharynx, and larynx treated in 2007-2015 were assessed for dysphagia post-treatment by telephone interview and videofluoroscopy (VFS)...
September 8, 2017: Dysphagia
https://www.readbyqxmd.com/read/28885456/tumor-necrosis-factor-alpha-secreted-from-oral-squamous-cell-carcinoma-contributes-to-cancer-pain-and-associated-inflammation
#12
Nicole N Scheff, Yi Ye, Aditi Bhattacharya, Justin MacRae, Dustin H Hickman, Atul K Sharma, John C Dolan, Brian L Schmidt
Oral cancer patients report severe pain during function. Inflammation plays a role in the oral cancer microenvironment; however, the role of immune cells and associated secretion of inflammatory mediators in oral cancer pain has not been well defined. In this study, we utilized two oral cancer mouse models: a cell line supernatant injection model and the 4-nitroquinoline-1-oxide (4NQO) chemical carcinogenesis model. We used the two models to study changes in immune cell infiltrate and orofacial nociception associated with oral squamous cell carcinoma (oSCC)...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28883766/intraoral-stents-in-preventing-adverse-radiotherapeutic-effects-in-lip-cancer-patients
#13
Breno A Rocha, Lucianne M C Lima, Lívia M R Paranaíba, Angel da S Martinez, Maria Betânia de O Pires, Edimilson M de Freitas, Camilla V Vilas Boas, Mário R de Melo Filho
AIM: To fabricate and evaluate the efficacy of individualized intraoral stents to minimize the potential side effects of radiation on oral tissues in patients with early stages of lip cancer. BACKGROUND: Lower lip cancer is a common tumor found almost exclusively in middle-aged and elderly males. Surgery is the most common treatment of choice, although for less extensive lesions, exclusive radiotherapy may be preferred. Some studies have found that the use of intraoral stents in patients with intraoral cancer (e...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28881626/relevance-of-ccl3-ccr5-axis-in-oral-carcinogenesis
#14
Janine Mayra da Silva, Tálita Pollyanna Moreira Dos Santos, Lays Martin Sobral, Celso Martins Queiroz-Junior, Milene Alvarenga Rachid, Amanda E I Proudfoot, Gustavo Pompermaier Garlet, Aline Carvalho Batista, Mauro Martins Teixeira, Andréia Machado Leopoldino, Remo Castro Russo, Tarcília Aparecida Silva
The chemokine CCL3 is a chemotactic cytokine crucial for inflammatory cell recruitment in homeostatic and pathological conditions. CCL3 might stimulate cancer progression by promoting leukocyte accumulation, angiogenesis and tumour growth. The expression of CCL3 and its receptors CCR1 and CCR5 was demonstrated in oral squamous cell carcinoma (OSCC), but their role was not defined. Here, the functions of CCL3 were assessed using a model of chemically induced tongue carcinogenesis with 4-nitroquinoline-1-oxide (4NQO)...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28876624/lingual-fibrolipoma-a-rare-clinicopathological-entity
#15
S Mungul, S Maharaj, S D Masege
Lipoma is a relatively common benign tumour occurring at sites of the body which are rich in adipose tissue. Due to sparsity of adipose tissue within the oral cavity, lipoma rarely presents in this region. Fibrolipoma of the tongue is a rare lesion. There are only 14 cases reported in the literature. An 85-year-old patient presented with a painless mass on the tongue interfering with eating. There were no risk factors for malignancy and no family history of malignant diseases. Although intraoperatively the lesion was locally infiltrative, histopathology revealed a rare benign fibrolipoma...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28870248/functional-and-quality-of-life-outcomes-after-partial-glossectomy-a-multi-institutional-longitudinal-study-of-the-head-and-neck-research-network
#16
Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R Harris, Daniel A O'Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay, Risto-Pekka Happonen, Ilpo Kinnunen, Irjala Heikki, Tero Soukka, Juhani Laine
BACKGROUND: While aggressive treatment for oral cancer may optimize survival, decrements in speech and swallowing function and quality of life often result. This exploratory study investigated how patients recover their communicative function, swallowing ability, and quality of life after primary surgery [with or without adjuvant (chemo)radiation therapy] for tongue cancer over the course of the first year post-operation. METHODS: Patients treated for oral cancer at three institutions (University of Alberta Hospital, Mount Sinai Beth Israel Medical Center, and Turku University Hospital) were administered patient-reported outcomes assessing speech [Speech Handicap Index (SHI)], swallowing [(M...
September 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28862204/epidemiological-profile-of-head-and-neck-cancer-patients-in-western-uttar-pradesh-and-analysis-of-distributions-of-risk-factors-in-relation-to-site-of-tumor
#17
Mohammad Shadab Alam, Shahid Ali Siddiqui, Roshan Perween
BACKGROUND: Head and neck cancers (HNCs) are a major form of cancers in India. The spectrum varies from place to place within the country because of significant diversified risk factors. AIMS AND OBJECTIVE: To study, epidemiology and risk factors of HNC patients from Western Uttar Pradesh and to find out the correlation between risk factors and different anatomical regions involved. MATERIALS AND METHODS: All patients with histologically confirmed diagnoses of HNC between January 2011 and December 2013 were selected from hospital records...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28861702/simulation-of-facial-expressions-using-person-specific-semg-signals-controlling-a-biomechanical-face-model
#18
Merijn Eskes, Alfons J M Balm, Maarten J A van Alphen, Ludi E Smeele, Ian Stavness, Ferdinand van der Heijden
PURPOSE: Functional inoperability in advanced oral cancer is difficult to assess preoperatively. To assess functions of lips and tongue, biomechanical models are required. Apart from adjusting generic models to individual anatomy, muscle activation patterns (MAPs) driving patient-specific functional movements are necessary to predict remaining functional outcome. We aim to evaluate how volunteer-specific MAPs derived from surface electromyographic (sEMG) signals control a biomechanical face model...
August 31, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28859669/epigenetic-silencing-of-mir-493-increases-the-resistance-to-cisplatin-in-lung-cancer-by-targeting-tongue-cancer-resistance-related-protein-1-tcrp1
#19
Yixue Gu, Zhijie Zhang, Jiang Yin, Jiahui Ye, Yin Song, Hao Liu, Yan Xiong, Minying Lu, Guopei Zheng, Zhimin He
BACKGROUND: The potential mechanisms regarding how methylation of microRNA(miRNA) CpG Island could regulate cancer cell chemo-resistance remains unclear. This study aims to explore the epigenetic dysregulation mechanism of miRNA-493 and the ability to modulate lung cancer cell chemotherapy resistance. METHODS: Real-time quantitative PCR (qRT-PCR) and In situ hybridization (ISH) were used to analyze the expression of miR-493 in lung cancer cell lines and tumor tissue, respectively...
August 31, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28857160/cancer-risk-of-lichen-planus-a-cohort-study-of-13-100-women-in-finland
#20
P M Halonen, M I Jakobsson, M A O Heikinheimo, A E Riska, M V Gissler, E I Pukkala
The association between lichen planus (LP) and cancer has been under debate for decades. We studied the connection via population-based Finnish register data. All women with the diagnosis of LP (n=13,100) were identified from the Finnish Hospital Discharge Registry from 1969-2012. These patients were linked with subsequent cancer diagnoses from the Finnish Cancer Registry until 2014. Standardized Incidence Ratios (SIRs) were counted for different cancers by dividing the observed numbers of cancers by expected numbers, which were based on national cancer incidence rates...
August 31, 2017: International Journal of Cancer. Journal International du Cancer
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