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https://www.readbyqxmd.com/read/29790310/anticancer-activity-of-chlorhexidine-and-cranberry-extract-an-in-vitro-study
#1
Mahesh R Khairnar, Umesh Wadgave, Harish Jadhav, Rahul Naik
Introduction: Oral cancer is considered to be a global pandemic. The study was conducted to assess the anti-cancer activities of Chlorhexidine (CHX) and Cranberry against oral cancer cell lines. Material and Methods: Anticancer activity of CHX and Cranberry extract (CE) was assessed against AW13516 (poorly to moderately differentiated squamous cell carcinoma of tongue) and KB (Nasopharyngeal carcinoma) using Sulforhodamine B (SRB) assay at the Advanced Centre for Treatment Research and Education in Cancer (ACTREC) Mumbai, India...
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29771835/the-arterialized-facial-artery-musculo-mucosal-island-flap-for-post-oncological-tongue-reconstruction
#2
Alessandro Moro, Gianmarco Saponaro, Piero Doneddu, Daniele Cervelli, Sandro Pelo, Giulio Gasparini, Umberto Garagiola, Giuseppe D'Amato, Mattia Todaro
BACKGROUND: In 1992, Pribaz described the facial artery musculomucosal flap (FAMM), an axial musculomucosal flap based on the facial artery. The FAMM flap, a modification of the nasolabial and buccal mucosal flaps, is widely used in the reconstruction of defects in the oral cavity. Many modifications of this flap have been described in the literature. Here we aimed to explore the use of an arterialized tunnelized FAMM island flap (a-FAMMIF) for the reconstruction tongue defects after tumor resection...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29766652/mucosal-microflora-in-head-and-neck-cancer-patients
#3
A Almståhl, C Finizia, A Carlén, B Fagerberg-Mohlin, T Alstad
OBJECTIVE: To analyse the tongue and buccal microflora prospectively in head and neck cancer patients treated with radiation therapy (RT). METHODS: In 33 dentate patients, microbial samples from the tongue and buccal mucosa were collected pretreatment, during treatment, and 6 months, 1 year and 2 years post-treatment. Microorganisms associated with oral health and oral disorders were analysed using cultivation technique. Oral mucositis was scored at the appointment during treatment...
May 15, 2018: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/29765527/lpmab-23-recognizing-cancer-type-podoplanin-is-a-novel-predictor-for-a-poor-prognosis-of-early-stage-tongue-cancer
#4
Akihiro Miyazaki, Hiromi Nakai, Tomoko Sonoda, Yoshihiko Hirohashi, Mika K Kaneko, Yukinari Kato, Yoshihiko Sawa, Hiroyoshi Hiratsuka
Purpose: We report that the reactivity of a novel monoclonal antibody LpMab-23 for human cancer-type podoplanin (PDPN) is a predictor for a poor prognosis of tongue cancer. Patients and Methods: The association between LpMab-23-recognizing cancer-type PDPN expression and clinical/pathological features were analyzed on 60 patients with stage I and II tongue cancer treated with transoral resection of the primary tumor. Results: In the mode of invasion, the LpMab-23-dull/negative cases were significantly larger in cases with low-grade malignancies and without late cervical lymph node metastasis, than in cases with high-grade malignancies and the metastasis...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29762448/pectoralis-major-musculocutaneous-flap-with-a-midline-sternal-skin-paddle-for-head-and-neck-reconstruction-a-new-design
#5
Jeongseok Oh, Hee Chang Ahn, Seungki Youn, Kyung Tae
PURPOSE: The pectoralis major musculocutaneous (PMMC) flap is a classic flap for head and neck reconstruction, relatively unpopular with the advancement of microsurgery and free flaps. The classic parasternal paddle design provided a thick flap with a small rotation arch leaving objectionable scarring. Our new symmetric midsternal design overcomes these problems. METHODS: Chart review was done from the years 2000 to 2017. Flap skin paddle was placed symmetrically on both sides of the midsternal line...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29761586/preoperative-predictors-of-occult-nodal-disease-in-ct1n0-oral-cavity-squamous-cell-carcinoma-review-of-2623-cases
#6
Kevin Y Zhan, Patrick F Morgan, David M Neskey, Joanne J Kim, Andrew T Huang, Elizabeth Garrett-Mayer, Terry A Day
BACKGROUND: Nodal disease predicts survival in oral cavity squamous cell carcinoma (SCC). Currently, no large studies on predictors of occult nodal disease in cT1N0 oral cavity SCC exist. METHODS: The National Cancer Database (NCDB) review for cT1N0 oral cavity SCC with surgical resection and elective neck dissection (END). RESULTS: The number of patients found with occult nodal disease was 2623 (15.1%). In multivariable regression, female sex and tumor differentiation predict occult nodal disease...
May 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29760380/a-new-inhibitor-of-glucose-6-phosphate-dehydrogenase-blocks-pentose-phosphate-pathway-and-suppresses-malignant-proliferation-and-metastasis-in-vivo
#7
Luigi Mele, Francesca Paino, Federica Papaccio, Tarik Regad, David Boocock, Paola Stiuso, Angela Lombardi, Davide Liccardo, Gabriella Aquino, Antonio Barbieri, Claudio Arra, Clare Coveney, Marcella La Noce, Gianpaolo Papaccio, Michele Caraglia, Virginia Tirino, Vincenzo Desiderio
Pentose phosphate pathway (PPP) is a major glucose metabolism pathway, which has a fundamental role in cancer growth and metastasis. Even though PPP blockade has been pointed out as a very promising strategy against cancer, effective anti-PPP agents are not still available in the clinical setting. Here we demonstrate that the natural molecule polydatin inhibits glucose-6-phosphate dehydrogenase (G6PD), the key enzyme of PPP. Polydatin blocks G6PD causing accumulation of reactive oxygen species and strong increase of endoplasmic reticulum stress...
May 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29754211/awareness-of-dysgeusia-and-gustatory-tests-in-patients-undergoing-chemotherapy-for-breast-cancer
#8
Sayaka Kuba, Rie Fujiyama, Kosho Yamanouchi, Michi Morita, Chika Sakimura, Toshiko Hatachi, Megumi Matsumoto, Hiroshi Yano, Mitsuhisa Takatsuki, Naomi Hayashida, Takeshi Nagayasu, Susumu Eguchi
PURPOSE: We analyzed the prevalence of gustatory test abnormalities in breast cancer (BC) patients undergoing chemotherapy. METHODS: We enrolled 43 BC patients undergoing chemotherapy and 38 BC patients who had never undergone chemotherapy (control group). Two gustatory tests were conducted: an instillation method examining the threshold for four basic taste stimuli and an electrogustometry method measuring the threshold for perception with electric stimulation at the front two-thirds of the tongue (cranial nerve VII) and at the back third of the tongue (cranial nerve IX)...
May 12, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29750853/depth-of-invasion-on-pathological-outcomes-in-clinical-low-stage-oral-tongue-cancer-patients
#9
Maheer M Masood, Douglas R Farquhar, Jessica P Vanleer, Samip N Patel, Trevor G Hackman
OBJECTIVES: Depth of invasion was added to the 8th edition American Joint Committee on Cancer guidelines for T staging of HPV-negative oral cavity squamous cell carcinoma. Our aim is to determine the impact of depth of invasion on pathological variables and outcomes in low-stage tongue cancer patients. We also examine the impact of tumor thickness and tumor clinical staging for comparison. SUBJECTS AND METHODS: All clinical T1/T2 N0 HPV negative tongue squamous cell carcinoma patients who received elective neck dissections at our institution between 2000 and 2015 were included...
May 11, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29747237/treponema-denticola-chymotrypsin-like-proteinase-is-present-in-early-stage-mobile-tongue-squamous-cell-carcinoma-and-related-to-the-clinicopathological-features
#10
Dyah Listyarifah, Mikko T Nieminen, Laura K Mäkinen, Caj Haglund, Daniel Grenier, Valtteri Häyry, Dan Nordström, Marcela Hernandez, Tülay Yucel-Lindberg, Taina Tervahartiala, Mari Ainola, Timo Sorsa, Jaana Hagström
BACKGROUND: Certain periodontopathogenic bacteria have been linked to cancers. Treponema denticola (Td) is associated with severe periodontitis. Chymotrypsin-like proteinase (CTLP), a major virulence factor of Td, can degrade various host proteins and peptides, and modulate inflammatory responses. However the role of Td in the tongue carcinogenesis remains unknown. This study aimed to investigate the presence of Td-CTLP in early-stage mobile tongue squamous cell carcinoma (MTSCC) and its relation to clinical and pathological characteristics...
May 10, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29746367/lingual-tonsillectomy-likely-does-not-improve-outcomes-for-squamous-cell-carcinoma-of-the-head-and-neck-from-an-unknown-primary-site
#11
Justin Wray, Robert J Amdur, Kaitlin M Christopherson, Christopher G Morris, Peter T Dziegielewski, Brian J Boyce, William M Mendenhall
OBJECTIVE: Patients with mucosal squamous cell carcinoma (SCC) of the head and neck almost always have a primary site in the base of tongue or tonsillar fossa. Lingual tonsillectomy has recently been advocated as part of the diagnostic evaluation as opposed to directed biopsies of the base of tongue and thought to possibly result in an increased likelihood or cure. The purpose of this project is to determine whether this is probable. MATERIALS AND METHODS: We reviewed the medical records of patients treated with primary radiotherapy (RT) between January 1983 and March 2013...
May 10, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29743120/cavernous-sinus-involvement-in-human-papillomavirus-associated-oropharyngeal-squamous-cell-carcinoma-case-report-of-an-atypical-site-of-distant-metastasis
#12
David Forner, Derek Wilke, Matthew H Rigby, Sidney Croul, Anuradha Mishra, Emad Massoud, David B Clarke, Nathan Lamond
BACKGROUND: HPV-associated OSCC (HPV-OSCC) has been determined to be a distinct disease entity from non-HPV associated OSCC. Patients affected by HPV-OSCC generally have a more favourable prognosis, with improved rates of locoregional control and survival compared with their non-HPV counterparts. Despite this, HPV-OSCC has a similar rate of distant metastases. Interestingly, recent evidence has emerged that demonstrates more frequent atypical metastasis patterns when compared to non-HPV associated disease...
May 9, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29735981/grainyhead-like-2-grhl2-knockout-abolishes-oral-cancer-development-through-reciprocal-regulation-of-the-map-kinase-and-tgf-%C3%AE-signaling-pathways
#13
Wei Chen, Kyung L Kang, Abdullah Alshaikh, Saaket Varma, Yi-Ling Lin, Ki-Hyuk Shin, Reuben Kim, Cun-Yu Wang, No-Hee Park, Katharina Walentin, Kai M Schmidt-Ott, Mo K Kang
Grainyhead-Like 2 (GRHL2) is an epithelial-specific transcription factor that regulates epithelial morphogenesis and differentiation. Prior studies suggested inverse regulation between GRHL2 and TGF-β in epithelial plasticity and potential carcinogenesis. Here, we report the role of GRHL2 in oral carcinogenesis in vivo using a novel Grhl2 knockout (KO) mouse model and the underlying mechanism involving its functional interaction with TGF-β signaling. We developed epithelial-specific Grhl2 conditional KO mice by crossing Grhl2 floxed mice with those expressing CreER driven by the K14 promoter...
May 8, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29735437/-effect-of-cordycepin-on-apoptosis-and-autophagy-of-tongue-cancer-cells-in-vitro-and-the-molecular-mechanism
#14
Qing-Wei Zheng, Shu-Xian Gao, Jie Lv, Deng-Yu Chen, Jie Chen, Hui-Hui Li, Jun-Chang Guan
OBJECTIVE: To study the effect of cordycepin on cell cycle, apoptosis and autophagy of human tongue cancer TCA-8113 cells and explore the mechanism of cordycepin for inhibiting the occurrence of tongue cancer. METHODS: CCK-8 method was used to assess the inhibitory effect of cordycepin on TCA-8113 cell proliferation in vitro. The cell cycle and cell apoptosis of TCA-8113 cells treated with different concentrations of cordycepin were analyzed using flow cytometry...
April 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29734474/comparison-of-tumor-volume-thickness-and-t-classification-as-predictors-of-outcomes-in-surgically-treated-squamous-cell-carcinoma-of-the-oral-tongue
#15
Manish Mair, Deepa Nair, Sudhir Nair, Akshat Malik, Aseem Mishra, Sadhana Kannan, Saurabh Bobdey, Hitesh Singhvi, Pankaj Chaturvedi
BACKGROUND: As per TNM classification, superficial tumors with a favorable prognosis are fallaciously clubbed together with unfavorable, deeply infiltrating lesions in the same classification. METHODS: This is a retrospective study of 588 patients with treatment-naive oral tongue cancers. Binary logistic regression was used to identify predictors of nodal metastasis and extracapsular spread (ECS) using tumor volume and thickness as separate models. The C-index was generated to quantify predictive accuracy of T classification, thickness, and tumor volume for survival...
May 7, 2018: Head & Neck
https://www.readbyqxmd.com/read/29731822/cbx3-hp1%C3%AE-is-upregulated-in-tongue-squamous-cell-carcinoma-and-is-associated-with-an-unfavorable-prognosis
#16
Huayong Zhang, Xiaoyan Fu, Xuan Su, Ankui Yang
Increased expression of CBX3/HP1γ, a core component of heterochromatin protein 1, has recently proved to be involved in human tumorigenesis and patient prognosis. The present study aimed to investigate the expression of CBX3/HP1γ and its clinicopathological significance in primary tongue squamous cell carcinoma (TSCC). Gene expression profiles of CBX3/HP1γ in TSCC from Oncomine database were analyzed. The expression of CBX3/HP1γ at protein level was measured using immunohistochemistry (IHC). The potential associations between CBX3/HP1γ expression and multiple clinicopathological parameters were estimated using the Chi square test...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29720147/crbp-1-over-expression-is-associated-with-poor-prognosis-in-tongue-squamous-cell-carcinoma
#17
Yue Chen, Tian Tian, Min-Jie Mao, Wei-Ye Deng, Hao Li
BACKGROUND: Tongue squamous cell carcinoma (TSCC) is one of the most common malignancies of oral squamous cell carcinomas. Cellular retinol binding protein-1 (CRBP-1) as a carrier protein transports retinol from the liver storage site to peripheral tissue. Up-regulated expression of CRBP-1 is associated with some tumor types such as prostate cancer, breast cancer and ovarian cancer as reported, but its role in TSCC remains uncertain. METHODS: In this study, an integrated bioinformatics analysis based on the multiple cancer microarray data sets available from Oncomine database was conducted to view the differential expression of CRBP-1 between TSCC and the adjacent non-tumorous tissues...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29712503/disparities-in-screening-for-head-and-neck-cancer-evidence-from-the-nhanes-2011-2014
#18
Adam Kravietz, Prashant Angara, Mina Le, Zoukaa Sargi
Objective To measure the association between race and head and neck cancer screening and education. Study Design Nationally representative survey. Setting US National Center for Health Statistics. Subjects and Methods Pooled data from the 2011-2014 National Health and Nutrition Examination Survey were used to examine disparities in head and neck cancer education and screening among US citizens aged ≥18 years. We measured the association between race and head and neck cancer education and screening, adjusting for age, sex, education, income, and health insurance...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29707840/perineural-invasion-independent-prognostic-factor-in-oral-cancer-that-warrants-adjuvant-treatment
#19
Deepa Nair, Manish Mair, Hitesh Singhvi, Aseem Mishra, Sudhir Nair, Jaiprakash Agrawal, Pankaj Chaturvedi
BACKGROUND: Controversy exists regarding the administration of adjuvant radiotherapy (RT) when perineural invasion (PNI) is the only adverse histological feature. The purpose of this study was to evaluate the impact of PNI on the survival of patients with oral cavity squamous cell carcinoma (SCC). METHODS: A retrospective study of 1524 treatment naive patients with oral cavity SCC who underwent surgery from January 2012 to March 2015 was conducted. Survival analysis was performed using Cox regression model...
April 29, 2018: Head & Neck
https://www.readbyqxmd.com/read/29706184/definitive-chemoradiation-for-locally-advanced-oral-cavity-cancer-a-20-year-experience
#20
Corey C Foster, James M Melotek, Ryan J Brisson, Tanguy Y Seiwert, Ezra E W Cohen, Kerstin M Stenson, Elizabeth A Blair, Louis Portugal, Zhen Gooi, Nishant Agrawal, Everett E Vokes, Daniel J Haraf
OBJECTIVES: Definitive chemoradiation (CRT) for oral cavity squamous cell carcinoma (OC-SCC) is often criticized for poor efficacy or toxicity. We describe a favorable 20-year experience of primary CRT for locally-advanced OC-SCC. MATERIALS AND METHODS: Patients with locally-advanced, stage III/IV OC-SCC receiving primary concomitant CRT on protocols from 1994 to 2014 were analyzed. Chemotherapy included fluorouracil and hydroxyurea with other third agents. Radiotherapy (RT) was delivered once or twice daily to a maximum dose of 70-75 Gy...
May 2018: Oral Oncology
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