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https://www.readbyqxmd.com/read/29793057/ellagic-acid-protects-from-myelin-associated-sphingolipid-loss-in-experimental-autoimmune-encephalomyelitis
#1
Rebeca Busto, Jorge Serna, Aránzazu Perianes-Cachero, Rocío Quintana-Portillo, David García-Seisdedos, Alberto Canfrán-Duque, Carlos L Paino, Milagros Lerma, María E Casado, Antonia Martín-Hidalgo, Eduardo Arilla-Ferreiro, Miguel A Lasunción, Óscar Pastor
Experimental autoimmune encephalomyelitis (EAE), the most common model for multiple sclerosis, is characterized by inflammatory cell infiltration into the central nervous system and demyelination. Previous studies have demonstrated that administration of some polyphenols may reduce the neurological alterations of EAE. In this work, we show that ellagic acid, a polyphenolic compound, is beneficial in EAE, most likely through stimulation of ceramide biosynthesis within the brain. EAE was induced in Lewis rats by injection of guinea-pig spinal cord tissue along with Freund's complete adjuvant containing Mycobacterium tuberculosis...
May 21, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29793054/bacillus-clausii-inhibits-bone-loss-by-skewing-treg-th17-cell-equilibrium-in-postmenopausal-osteoporotic-mice-model
#2
Hamid Y Dar, Subhashis Pal, Prashant Shukla, Pradyumna K Mishra, Geetanjali B Tomar, Naibedya Chattopadhyay, Rupesh K Srivastava
OBJECTIVES: Postmenopausal osteoporosis is one of most commonly occurring skeletal diseases leading to bone loss and fragility. Probiotics have been associated with various immunomodulatory properties and thus can be exploited to enhance bone health. In the present study, we report, to our knowledge for the first time, that oral administration of Bacillus clausii (BC) in postmenopausal osteoporotic (OVX) mice model enhances bone health. METHODS: BC was selected as probiotic of choice due to its established immunomodulatory properties...
March 20, 2018: Nutrition
https://www.readbyqxmd.com/read/29792899/protective-effect-of-exendin-4-treatment-on-erectile-dysfunction-induced-by-chronic-methylglyoxal-administration-in-rats
#3
Selvinaz Dalaklioglu, Arda Tasatargil, Nilay Kuscu, Soner Celik, Ciler Celik-Ozenci, Sebahat Ozdem, Ayse Barutcigil, Ikbal Kucukcetin
OBJECTIVE: The aim of this study was to investigate the effect of chronic exendin-4 (Ex-4) treatment on corpus cavernosum (CC) dysfunction in methylglyoxal (MGO) administered rats. METHODS: Male rats were divided into four groups as control, MGO (75 mg/kg/day in drinking water for 12 weeks), MGO + low-dose Ex-4 (0.1 μg/kg twice daily subcutaneously for 12 weeks concomitant with MGO), and MGO + high-dose Ex-4 (1 μg/kg twice daily subcutaneously for 12 weeks concomitant with MGO)...
May 21, 2018: Peptides
https://www.readbyqxmd.com/read/29792584/neonatal-intake-of-oleanolic-acid-attenuates-the-subsequent-development-of-high-fructose-diet-induced-non-alcoholic-fatty-liver-disease-in-rats
#4
T T Nyakudya, E Mukwevho, P Nkomozepi, K H Erlwanger
Dietary manipulations during the early postnatal period are associated with the development of metabolic disorders including non-alcoholic fatty liver disease (NAFLD) or long-term protection against metabolic dysfunction. We investigated the potential hepatoprotective effects of neonatal administration of oleanolic acid (OA), a phytochemical, on the subsequent development in adulthood, of dietary fructose-induced NAFLD. Male and female suckling rats (n=112) were gavaged with; distilled water (DW), OA (60 mg/kg), high fructose solution (HF; 20% w/v) and OA+HF (OAHF) for 7 days...
May 24, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29792423/trace-organic-pollutant-removal-by-vuv-uv-chlorine-process-feasibility-investigation-for-drinking-water-treatment-on-a-mini-fluidic-vuv-uv-photoreaction-system-and-a-pilot-photoreactor
#5
Mengkai Li, Mengyu Hao, Laxiang Yang, Hong Yao, James R Bolton, Ernest R Blatchley, Zhimin Qiang
The vacuum-ultraviolet/ultraviolet/chlorine (VUV/UV/chlorine) process, with a VUV/UV mercury lamp used as the light source, was found to be a highly efficient advanced oxidation process (AOP) in a previous study. Hence, its application feasibility for trace organic pollutant removal from drinking water becomes attractive. In this work, a bench-scale mini-fluidic VUV/UV photoreaction system was used to determine the degradation kinetics of sulfamethazine (SMN), a model sulfonamide antibiotic frequently detected with trace levels in aquatic environments...
May 24, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29792419/as-iii-removal-from-drinking-water-by-carbon-nanotube-membranes-with-magnetron-sputtered-copper-performance-and-mechanisms
#6
Hongyan Luan, Quan Zhang, Guo-An Cheng, Haiou Huang
Current approaches for functionalizing carbon nanotubes (CNT) often utilize harsh chemical conditions and the resulting harmful wastes can cause various environmental and health concerns. In this study, magnetron-sputtering technique is facilely employed to functionalize CNT membranes by depositing Cu onto pre-made CNT membranes without using any chemical treatment. A comparative evaluation of the substrate polymeric membrane (MCE), MCE sputtered with copper (Cu/MCE), the pristine CNT membrane (CNT), and CNT membrane sputtered with Cu (Cu/CNT) shows that Cu/CNT possesses mechanically stable structures and similar membrane permeability as MCE...
May 24, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29791883/relationship-between-modification-of-activated-sludge-wastewater-treatment-and-changes-in-antibiotic-resistance-of-bacteria
#7
Ewa Korzeniewska, Monika Harnisz
Biological treatment processes at wastewater treatment plants (WWTPs), which are the most common methods of sewage treatment, could cause selective elimination and/or changes in the proportions of phenotypes/genotypes within bacterial populations in effluent. Therefore, WWTPs based on activated sludge used in sewage treatment constitute an important reservoir of enteric bacteria which harbour potentially transferable resistance genes. Together with treated wastewater, these microorganisms can penetrate the soil, surface water, rural groundwater supplies and drinking water...
May 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29791882/simulation-based-assessment-of-the-impact-of-fertiliser-and-herbicide-application-on-freshwater-ecosystems-at-the-three-gorges-reservoir-in-china
#8
Björn Scholz-Starke, Li Bo, Andreas Holbach, Stefan Norra, Tilman Floehr, Henner Hollert, Martina Roß-Nickoll, Andreas Schäffer, Richard Ottermanns
Dams have profound impacts on river ecosystems, amongst them inundation of land, altered dynamics of the water body or uprising reservoir backwaters influencing tributary or upstream river sections. Along the outstandingly ecologically important Yangtze River in China, the Three Gorges Reservoir (TGR) is the largest project, covering an area of 1080 km2 . From the beginning, the dam-project came in for criticism on increasing environmental risks due to sub-merging former industrial and urban areas. We simulated dynamics of biotic and abiotic components of the TGR ecosystem (trophic guilds of aquatic organisms, hydrodynamics, nutrients), as well as the behaviour of the herbicidal substance propanil and its metabolites 3,4-Dichloroaniline (DCA) and 3,3',4,4'-tetrachloroazoxybenzene (TCAB)...
May 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29791217/prevention-of-dehydration-in-hospital-patients
#9
Rebecca Shells, Nicola Morrell-Scott
Dehydration is widely linked to increased risk of mortality in patients who are acutely unwell, and it also increases the risk of further illness. Despite being recognised nationwide as a cause for concern, 45% of hospital patients will become dehydrated upon admission, suggesting that more needs to be done to prevent dehydration. The use of bedside water devices allows patients to drink freely without assistance. Access to these can reduce a patient's length of stay in hospital and minimise the risk of developing a urinary tract infection...
May 24, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29790543/a-bi-metallic-mof-catalyst-via-sensitive-detection-adsorption-of-fe-3-ions-for-size-selective-reaction-prompting
#10
Yang Li, Ziling Chang, Fangmin Huang, Pengyan Wu, Huacong Chu, Jian Wang
A cadmium(ii)-based MOF, Cd-MDIP, was successfully prepared by hydrothermal reaction between the tetra-carboxylic ligand 5,5'-methylenebisophthalic acid (H4MDIP) and cadmium perchlorate. The X-ray crystal structure analysis showed that there are two uncoordinated carboxyl groups in each ligand and a 1D elliptical channel along the [001] direction. Because of the existence of uncoordinated carboxyl groups within open frameworks, Cd-MDIP exhibited a high sensitivity (Stern-Volmer constant KSV = 4.13 × 104 L mol-1) and a low detection limit (80 nM) for Fe3+ ions in pure water, which is much lower than the national standard for Fe3+ in daily drinking water (5...
May 23, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29790140/-the-relationship-between-quality-of-life-and-psychological-and-behavioral-factors-in-patients-with-heart-failure-following-cardiac-resynchronization-therapy
#11
Jing Huang, Jin-Bo Fang, Yi-Heng Zhao
BACKGROUND: While cardiac resynchronization therapy improves the quality of life of patients with heart failure, some psychological and behavioral factors still affect the quality of life of these patients. However, information on the factors that affect the quality of life of these patients is limited. PURPOSE: To describe the quality of life and investigate the relationship between quality of life and behavioral and psychological factors such as depression, smoking, drinking, water and sodium restrictions, exercise, and adherence in patients with chronic heart failure following cardiac resynchronization therapy...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29789148/breakthrough-dynamics-of-s-metolachlor-metabolites-in-drinking-water-wells-transport-pathways-and-time-to-trend-reversal
#12
Julien Farlin, Tom Gallé, Michael Bayerle, Denis Pittois, Stephan Köppchen, Martina Krause, Diana Hofmann
We present the results of a two years study on the contamination of the Luxembourg Sandstone aquifer by metolachlor-ESA and metolachlor-OXA, two major transformation products of s-metolachlor. The aim of the study was twofold: (i) assess whether elevated concentrations of both transformation products (up to 1000 ng/l) were due to fast flow breakthough events of short duration or the signs of a contamination of the entire aquifer and (ii) estimate the time to trend reversal once the parent compound was withdrawn from the market...
May 16, 2018: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/29789130/the-effects-of-alcohol-on-plasma-lipid-mediators-of-inflammation-resolution-in-patients-with-type-2-diabetes-mellitus
#13
Anne Barden, Sujata Shinde, Michael Phillips, Lawrence Beilin, Emilie Mas, Jonathan M Hodgson, Ian Puddey, Trevor A Mori
BACKGROUND: Type 2 diabetes mellitus is characterized by peripheral insulin resistance and low-grade systemic inflammation. Inflammation resolution is recognised as an important process driven by specialised pro-resolving mediators of inflammation (SPMs) and has the potential to moderate chronic inflammation. Alcohol has the potential to affect synthesis of SPMs by altering key enzymes involved in SPM synthesis and may influence ongoing inflammation associated with Type 2 diabetes mellitus...
June 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29789027/ethanolamine-enhances-intestinal-functions-by-altering-gut-microbiome-and-mucosal-anti-stress-capacity-in-weaned-rats
#14
Jian Zhou, Xia Xiong, Ke-Xing Wang, Li-Jun Zou, Peng Ji, Yu-Long Yin
Ethanolamine (Etn) contained in milk is the base constituent of phosphatidylethanolamine and is required for the proliferation of intestinal epithelial cells and bacteria, which is important for maintenance of the gut microbiome and intestinal development. The present study investigated the effect of Etn on intestinal function and microbiome using 21-d-old Sprague-Dawley rats treated with 0, 250, 500 and 1000 μm Etn in drinking water for 2 weeks immediately after weaning. Growth performance, intestinal morphology, antioxidant capacity and mucosal immunity, as well as gut microbiota community composition, were evaluated...
May 23, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29788053/reversing-ongoing-chronic-intestinal-inflammation-and-fibrosis-by-sustained-block-of-il-12-and-il-23-using-a-vaccine-in-mice
#15
Qingdong Guan, Carolyn R Weiss, Shuhe Wang, Gefei Qing, Xi Yang, Richard J Warrington, Charles N Bernstein, Zhikang Peng
Interleukin (IL)-12 and IL-23 that share subunit p40 are important cytokines in the pathogenesis of inflammatory bowel disease. We reported that mouse p40 peptide-based vaccines ameliorated intestinal inflammation in the prevention of trinitrobenzene sulfonic acid (TNBS)-induced murine colitis model. Here, we evaluated whether administration of the vaccine after establishment of colitis would be effective in modifying both TNBS-induced and dextran sulfate sodium (DSS)-induced chronic colitis and the underlying immune mechanisms...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29787904/effective-and-sensitive-determination-of-eleven-disinfection-byproducts-in-drinking-water-by-dllme-and-gc-ms
#16
Jiwon On, Heesoo Pyo, Seung-Woon Myung
The aim of this study was to optimize the dispersive liquid-liquid microextraction (DLLME) parameters for simultaneous analysis through DLLME-gas chromatography-mass spectrometry (GC-MS) of six iodo-trihalomethanes, four haloacetonitriles, and one halonitromethane, which are residual disinfection products found in drinking water. Eleven disinfection by-product (DBPs) remaining in aqueous samples were extracted and concentrated using a simple, rapid, and environmentally friendly DLLME method, and then analyzed simultaneously by GC-MS...
May 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29786868/cis-acting-allele-specific-expression-ase-differences-induced-by-alcohol-and-impacted-by-sex-as-well-as-parental-genotype-of-origin
#17
Chiao-Ling Lo, Lawrence Lumeng, Richard L Bell, Tiebing Liang, Amy C Lossie, Williams M Muir, Feng C Zhou
BACKGROUND: Alcohol use disorders (AUDs) are influenced by complex interactions between the genetics of the individual and their environment. We have previously identified hundreds of polygenic genetic variants between the selectively bred high and low alcohol drinking (HAD and LAD) rat lines. Here we report allele specific expression (ASE) differences, between the HAD2 and LAD2 rat lines. METHODS: The HAD2 and LAD2 rats which have been sequenced were reciprocally crossed to generate 10 litters of F1 progeny...
May 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29786601/heterogeneous-photocatalysis-and-its-potential-applications-in-water-and-wastewater-treatment-a-review
#18
Syed N Ahmed, Waseem Haider
There has been a considerable amount of research in the development of sustainable water treatment techniques capable of improving the quality of water. Unavailability of drinkable water is a crucial issue especially in regions where conventional drinking water treatment systems fail to eradicate aquatic pathogens, toxic metal ions and industrial waste. The research and development in this area have given rise to a new class of processes called Advanced Oxidation Processes, particularly in the form of heterogeneous photocatalysis, which converts photon energy into chemical energy...
May 22, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29786582/characteristics-of-epidemiology-of-dental-caries-in-children-from-regions-with-high-and-optimum-fluorine-content-in-drinking-water
#19
Valentina Trufanova, Olha Sheshukova, Vadym Davydenko, Tetiana Polishchuk, Sofia Bauman, Vitalina Dobroskok
OBJECTIVE: Introduction: Prevention of dental diseases in children is the priority item on the modern dentistry agenda. Among the undeniable factors known as contributing into caries incidence, there is fluoride content in the external environment, especially in drinking water, which is the main source of fluoride intake. The aim: This study is aimed at evaluating dental caries indices in children and adolescents inhabiting in areas with optimal and high-level fluoride concentration in drinking water and assessing their level of oral hygiene...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786576/the-histological-and-electron-microscopic-study-of-the-parotid-salivary-gland-in-dehydrated-rats-of-different-ages
#20
Denys P Biletskyy, Oleg A Ustiansky, Olena S Maksymova, Pavel A Moskalenko, Alexey A Tymoshenko, Anna S Degtyarenko, Viktoriia Yu Harbuzova, Yevhen I Dubovyk, Andrii P Voznyi, Gennadii F Tkach
OBJECTIVE: Introduction: Water-salt metabolism disorders is one of the main factor of salivary gland pathology development. The aim: To study the morphological structure of the parotid salivary gland of young, mature and old rats at micro- and ultrastructural levels under water deprivation. PATIENTS AND METHODS: Materials and methods: The experiment was carried out on thirty six laboratory male rats of different ages (young, mature and old). The rats of the control group received normal volume of drinking water...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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