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https://www.readbyqxmd.com/read/28350697/tritium-3-h-retention-in-mice-administered-as-hto-dto-or-as-3-h-labeled-amino-acids
#1
Nicholas D Priest, Melinda S J Blimkie, Heather Wyatt, Michelle Bugden, Laura A Bannister, Yann Gueguen, Jean-Rene Jourdain, Dmitry Klokov
The objective of this study was to compare the biokinetics of injected H-labeled light (HTO) and heavy (DTO) water in CBA/CaJ mice and to compare the organ distribution and/or body content of H administered by chronic ingestion for 1 mo to C57Bl/6J mice, as either H-labeled water or H-labeled amino acids (glycine, alanine and proline). HTO and DTO were administered to CBA/CaJ mice by single intraperitoneal injection and body retention was determined for up to 384 h post-injection. Tritium-labeled water or H-labeled amino acids were given to C57Bl/6J mice ad libitum for 30 d in drinking water...
May 2017: Health Physics
https://www.readbyqxmd.com/read/28344913/indoor-localisation-through-object-detection-within-multiple-environments-utilising-a-single-wearable-camera
#2
Colin Shewell, Chris Nugent, Mark Donnelly, Haiying Wang, Macarena Espinilla
The recent growth in the wearable sensor market has stimulated new opportunities within the domain of Ambient Assisted Living, providing unique methods of collecting occupant information. This approach leverages contemporary wearable technology, Google Glass, to facilitate a unique first-person view of the occupants immediate environment. Machine vision techniques are employed to determine an occupant's location via environmental object detection. This method provides additional secondary benefits such as first person tracking within the environment and lack of required sensor interaction to determine occupant location...
2017: Health and Technology
https://www.readbyqxmd.com/read/28344406/attribution-of-antibacterial-and-antioxidant-activity-of-cassia-tora-extract-toward-its-growth-promoting-effect-in-broiler-birds
#3
Jyoti Sahu, K M Koley, B D Sahu
AIM: The study was conducted to evaluate the attribution of antibacterial and antioxidant activity of methanolic extract of Cassia tora toward its growth promoting effect in broiler birds. MATERIALS AND METHODS: A limit test was conducted for C. tora extract in Wistar albino rats. Phytochemical screening of methanolic extract of leaves of C. tora was carried out. In-vitro antibacterial activity was measured by disc diffusion method. 1-day-old Ven Cobb broiler birds (n=90) were randomly allocated into three groups consisting of three replicates with 10 birds in each group...
February 2017: Veterinary World
https://www.readbyqxmd.com/read/28343139/oxytocin-in-corticosterone-induced-chronic-stress-model-focus-on-adrenal-gland-function
#4
Dušanka Stanić, Bosiljka Plećaš-Solarović, Duško Mirković, Predrag Jovanović, Slađana Dronjak, Bojan Marković, Tea Đorđević, Svetlana Ignjatović, Vesna Pešić
Chronic stress conditions can lead to considerable and extensible changes in physiological and psychological performances, and in emergence of risk for various somatic diseases. On the other hand, the neuropeptide oxytocin is reported to increase the resistance of the organism to stress and modulate activity of autonomic nervous system. Chronic corticosterone administration is used as a rat model for a state observed in terms of chronic stress exposure, when negative feedback mechanism of hypothalamus-pituitary-adrenal axis activity is disrupted...
March 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28343105/photoluminescence-light-up-detection-of-zinc-ion-and-imaging-in-living-cells-based-on-the-aggregation-induced-emission-enhancement-of-glutathione-capped-copper-nanoclusters
#5
Liyun Lin, Yuefang Hu, Liangliang Zhang, Yong Huang, Shulin Zhao
In this work, we prepared glutathione (GSH)-capped copper nanoclusters (Cu NCs) with red emission by simply adjusting the pH of GSH/Cu(2+) mixture at room temperature. A photoluminescence light-up method for detecting Zn(2+) was then developed based on the aggregation induced emission enhancement of GSH-capped Cu NCs. Zn(2+) could trigger the aggregation of Cu NCs, inducing the enhancement of luminescence and the increase of absolute quantum yield from 1.3% to 6.2%. GSH-capped Cu NCs and the formed aggregates were characterized, and the possible mechanism was also discussed...
March 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28343081/simultaneous-determination-of-226-ra-228-ra-and-210-pb-in-drinking-water-using-3m-empore%C3%A2-rad-disk-by-lsc-pls
#6
Jordi Fons-Castells, Javier Oliva, Joana Tent-Petrus, Montserrat Llauradó
A procedure for the rapid and simultaneous determination of (226)Ra, (228)Ra and (210)Pb in drinking water by means of extraction with a 3M Empore™ Radium RAD disk and liquid scintillation spectrometry is described. The selective elution of (210)Pb from the RAD disk and a multivariate calibration using partial least squares regression (PLS) are tested as methods to avoid overlap in the spectra between (228)Ra and (210)Pb. The validated procedure was tested with mixtures of radionuclides and interlaboratory materials; finally, it was applied to natural waters...
March 21, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28343041/characterization-of-regional-cold-hydrothermal-inflows-enriched-in-arsenic-and-associated-trace-elements-in-the-southern-part-of-the-duero-basin-spain-by-multivariate-statistical-analysis
#7
Elena Giménez-Forcada, Marisol Vega-Alegre, Susana Timón-Sánchez
Naturally occurring arsenic in groundwater exceeding the limit for potability has been reported along the southern edge of the Cenozoic Duero Basin (CDB) near its contact with the Spanish Central System (SCS). In this area, spatial variability of arsenic is high, peaking at 241μg/L. Forty-seven percent of samples collected contained arsenic above the maximum allowable concentration for drinking water (10μg/L). Correlations of As with other hydrochemical variables were investigated using multivariate statistical analysis (Hierarchical Cluster Analysis, HCA and Principal Component Analysis, PCA)...
March 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28343040/the-influence-of-lead-content-in-drinking-water-household-dust-soil-and-paint-on-blood-lead-levels-of-children-in-flin-flon-manitoba-and-creighton-saskatchewan
#8
Adam M Safruk, Erin McGregor, Melissa L Whitfield Aslund, Paul H Cheung, Celine Pinsent, Blair J Jackson, Alan T Hair, Murray Lee, Elliot A Sigal
Lead exposure continues to be an important health issue despite the general removal of lead sources in commercial and industrial applications. Low levels of lead exposure have been found to produce adverse neurodevelopmental effects in children with no evidence that a threshold exists for this critical endpoint. Blood lead levels (BLLs) were measured in children (n=118) under the age of 7years in the northern Canadian smelter community of Flin Flon, Manitoba and Creighton, Saskatchewan. An environmental sampling component was included to examine the relationship between lead content in outdoor soil, household dust, tap water, and paint within a given household and the corresponding BLLs in participating children...
March 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28342422/synergistic-desalination-of-potash-brine-impacted-groundwater-using-a-dual-adsorbent
#9
Nick P Gibb, James J Dynes, Wonjae Chang
The impact of saline mining effluent has been a significant environmental concern. Natural and modified clay-mineral adsorbents have been receiving increasing attention for salinity reduction of brine-impacted water, especially for natural resource extraction sites and surrounding environments. In this study, a dual-adsorbent treatment based on the sequential application of calcined layered double hydroxide (CLDH) and acid-treated zeolite was developed, evaluated and characterized for the desalination of potash brine-impacted groundwater...
March 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28341683/total-volume-and-composition-of-fluid-intake-and-mortality-in-older-women-a-cohort-study
#10
Wai H Lim, Germaine Wong, Joshua R Lewis, Charmaine E Lok, Kevan R Polkinghorne, Jonathan Hodgson, Ee M Lim, Richard L Prince
OBJECTIVES: The health benefits of 'drinking at least 8 glasses of water a day" in healthy individuals are largely unproven. We aimed to examine the relationship between total fluid and the sources of fluid consumption, risk of rapid renal decline, cardiovascular disease (CVD) mortality and all-cause mortality in elderly women. DESIGN, SETTING AND PARTICIPANTS: We conducted a longitudinal analysis of a population-based cohort study of 1055 women aged ≥70 years residing in Australia...
March 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28341391/mice-lacking-liver-specific-%C3%AE-catenin-develop-steatohepatitis-and-fibrosis-after-iron-overload
#11
Morgan E Preziosi, Sucha Singh, Erika V Valore, Chun-Ling Jung, Branimir Popovic, Minakshi Poddar, Shanmugam Nagarajan, Tomas Ganz, Satdarshan P Monga
BACKGROUND & AIMS: Iron overload disorders such as hereditary hemochromatosis and iron-loading anemias are a common cause of morbidity from liver diseases and increase risk of hepatic fibrosis and hepatocellular carcinoma (HCC). Once iron-induced damage occurs, treatment options are limited partly because of the lack of animal models recapitulating human disease, which do not exhibit relevant sequelae after chronic iron overload. METHODS: Since liver-specific β-catenin knockout mice (KO) are susceptible to injury, fibrosis and tumorigenesis following chemical carcinogen exposure, iron-overload diet was administered to KO and littermate control (CON) mice for various times...
March 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28341273/branched-chain-amino-acids-enhance-cyst-development-in-autosomal-dominant-polycystic-kidney-disease
#12
Junya Yamamoto, Saori Nishio, Fumihiko Hattanda, Daigo Nakazawa, Toru Kimura, Michio Sata, Minoru Makita, Yasunobu Ishikawa, Tatsuya Atsumi
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive development of kidney and liver cysts. The mammalian target of rapamycin (mTOR) cascade is one of the important pathways regulating cyst growth in ADPKD. Branched-chain amino acids (BCAAs), including leucine, play a crucial role to activate mTOR pathway. Therefore, we administered BCAA dissolved in the drinking water to Pkd1(flox/flox):Mx1-Cre (cystic) mice from four to 22 weeks of age after polyinosinic-polycytidylic acid-induced conditional Pkd1 knockout at two weeks of age...
March 21, 2017: Kidney International
https://www.readbyqxmd.com/read/28341147/cadmium-stimulates-myofibroblast-differentiation-and-mouse-lung-fibrosis
#13
Xin Hu, Jolyn Fernandes, Dean P Jones, Young-Mi Go
Increasing evidence suggests that Cd at levels found in the human diet can cause oxidative stress and activate redox-sensitive transcription factors in inflammatory signaling. Following inflammation, tissue repair often involves activation of redox-sensitive transcription factors in fibroblasts. In lungs, epithelial barrier remodeling is required to restore gas exchange and barrier function, and aberrant myofibroblast differentiation leads to pulmonary fibrosis. Contributions of exogenous exposures, such as dietary Cd, to pulmonary fibrosis remain incompletely defined...
March 21, 2017: Toxicology
https://www.readbyqxmd.com/read/28341053/water-use-on-nonirrigated-pasture-based-dairy-farms-combining-detailed-monitoring-and-modeling-to-set-benchmarks
#14
C D Higham, D Horne, R Singh, B Kuhn-Sherlock, M R Scarsbrook
Water use in intensively managed, confinement dairy systems has been widely studied, but few reports exist regarding water use on pasture-based dairy farms. The objective of this study was to quantify the seasonal pattern of water use to develop a prediction model of water use for pasture-based dairy farms. Stock drinking, milking parlor, and total water use was measured on 35 pasture-based, seasonal calving dairy farms in New Zealand over 2 yr. Average stock drinking water was 60 L/cow per day, with peak use in summer...
January 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28340995/an-overview-of-advanced-reduction-processes-for-bromate-removal-from-drinking-water-reducing-agents-activation-methods-applications-and-mechanisms
#15
REVIEW
Qian Xiao, Shuili Yu, Lei Li, Ting Wang, Xinlei Liao, Yubing Ye
Bromate (BrO3(-)) is a possible human carcinogen regulated at a strict standard of 10μg/L in drinking water. Various techniques to eliminate BrO3(-) usually fall into three main categories: reducing bromide (Br(-)) prior to formation of BrO3(-), minimizing BrO3(-) formation during the ozonation process, and removing BrO3(-) from post-ozonation waters. However, the first two approaches exhibit low degradation efficiency and high treatment cost. The third workaround has obvious advantages, such as high reduction efficiency, more stable performance and easier combination with UV disinfection, and has therefore been widely implemented in water treatment...
February 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28340752/highly-sensitive-ratiometric-quantification-of-cyanide-in-water-with-gold-nanoparticles-via-resonance-rayleigh-scattering
#16
Yulán Hernández, Yves Coello, Raluca M Fratila, Jesús M de la Fuente, Troy A Lionberger
A highly sensitive and selective ratiometric sensor for the quantification of cyanide (CN(-)) in aqueous samples has been developed using spherical gold nanoparticles (AuNPs) stabilized by polysorbate 40 (PS-40). Three different AuNP sizes (14, 40 and 80nm mean diameters) were used to evaluate the response of the sensor using both colorimetric and Resonance Rayleigh Scattering (RRS) detection schemes. The best results were obtained for the sensor using 40nm AuNPs, for which the limits of detection (LODs) were found to be 100nmolL(-1) in a benchtop instrument and 500nmolL(-1) by the naked eye, values well below the maximum acceptable level for drinking water (1...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340741/controlled-synthesis-of-hollow-porous-carbon-spheres-for-enrichment-and-simultaneous-determination-of-nine-bisphenols-from-real-samples
#17
Zhenzhen Zhang, Jing Zhang, Yang Wang, Yao Tong, Lei Zhang
An extended one-step Stőber method was utilized for the preparation of core@shell spheres, which was made up of a thin layer of resorcinol-formaldehyde (RF) and a silica core. After the carbonization and template-removal process, hollow porous carbon spheres (HPCSs) were synthesized. The structure of HPCSs was characterized by scanning/transmission electron microscopy and N2 adsorption/desorption isotherms, Fourier transform infrared spectroscopy, energy dispersive X-ray spectrometer and Raman spectroscopy...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28339778/effects-of-an-induced-molt-using-cassava-meal-on-body-weight-loss-blood-physiology-ovarian-regression-and-postmolt-egg-production-in-late-phase-laying-hens
#18
N Gongruttananun, P Kochagate, K Poonpan, N Yu-Nun, J Aungsakul, N Sopa
This study was conducted to determine the effect of an induced molt using cassava meal on body weight, blood physiology, ovary, and postmolt performance in late-phase (74 wk old) H&N Brown laying hens. Hens were randomly assigned to 3 treatments of 90 birds each: 1) Controls withno induced molt (CONT); 2) molted by full feeding with cassava meal for 3 wk (FP3); and 3) molted by full feeding with cassava meal for 4 wk (FP4). Groups 2 and 3 were fed a pullet developer diet for 3 wk following treatment. During the molt period, the birds were exposed to an 8L:16D photoperiod and had access to drinking water at all times...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339172/maternal-high-fat-diet-consumption-enhances-offspring-susceptibility-to-dss-induced-colitis-in-mice
#19
Shima Bibi, Yifei Kang, Min Du, Mei-Jun Zhu
OBJECTIVE: Maternal high-fat diet (HFD) may alter the offspring intestinal immune system, thereby enhancing susceptibility toward inflammatory bowel disease. The objective of the current study was to investigate the impact of maternal HFD on offspring intestinal health using a mouse model of dextran sulfate sodium (DSS)-induced colitis. METHODS: Dams were provided with either HFD (60%) or control diet. After weaning, female offspring from both groups were kept on 45% HFD...
March 24, 2017: Obesity
https://www.readbyqxmd.com/read/28339083/health-risk-assessment-of-environmental-selenium-emerging-evidence-and-challenges-review
#20
Marco Vinceti, Tommaso Filippini, Silvia Cilloni, Annalisa Bargellini, Anna Valeria Vergoni, Aristides Tsatsakis, Margherita Ferrante
New data have been accumulated in the scientific literature in recent years which allow a more adequate risk assessment of selenium with reference to human health. This new evidence comes from environmental studies, carried out in populations characterized by abnormally high or low selenium intakes, and from high-quality and large randomized controlled trials with selenium recently carried out in the US and in other countries. These trials have consistently shown no beneficial effect on cancer and cardiovascular risk, and have yielded indications of unexpected toxic effects of selenium exposure...
March 24, 2017: Molecular Medicine Reports
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