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https://www.readbyqxmd.com/read/29777577/autologous-bone-marrow-mesenchymal-stem-cells-improve-the-quality-and-stability-of-vascularized-flap-surgery-of-irradiated-skin-in-pigs
#1
Christine Linard, Michel Brachet, Carine Strup-Perrot, Bruno L'homme, Elodie Busson, Claire Squiban, Valerie Holler, Michel Bonneau, Jean-Jacques Lataillade, Eric Bey, Marc Benderitter
Cutaneous radiation syndrome has severe long-term health consequences. Because it causes an unpredictable course of inflammatory waves, conventional surgical treatment is ineffective and often leads to a fibronecrotic process. Data about the long-term stability of healed wounds, with neither inflammation nor resumption of fibrosis, are lacking. In this study, we investigated the effect of injections of local autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs), combined with plastic surgery for skin necrosis, in a large-animal model...
May 18, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29771356/versatility-of-dorsal-metacarpal-artery-flaps-for-hand-burns
#2
Jennel M Carreras, Catherine McGee, Faisal Al-Mufarrej
Burns to the hands can be devastating injuries and early debridement and coverage can prevent these chronic problems. Reconstructive options for these defects include skin grafts, local, regional and distant flaps as well as free flaps. In this series we set out to demonstrate the versatility, durability and effectiveness of dorsal metacarpal artery flaps for primary soft tissue coverage This study involves a review of all consecutive patients who underwent acute soft tissue coverage using dorsal metacarpal artery flaps at our institution from December 2014 to December 2017...
May 16, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29770531/use-of-antibiotic-impregnated-resorbable-beads-reduces-pressure-ulcer-recurrence-a-retrospective-analysis
#3
Ibrahim Khansa, Jenny C Barker, Piya Das Ghatak, Chandan K Sen, Gayle M Gordillo
BACKGROUND: Recurrence of pressure ulcers remains common. We have employed resorbable antibiotic beads as a therapeutic strategy to deliver high local antibiotic concentrations to the debridement site. Our objective was to determine whether the use of resorbable antibiotic- beads would reduce pressure ulcer recurrence. METHODS: We reviewed all stage IV pressure ulcers treated with excision, partial ostectomy and flap coverage over 16 years. Baseline patient factors (location of ulcer, presence of osteomyelitis, preoperative prealbumin), surgical factors (type of flap, use of antibiotic beads, bone culture results) and postoperative outcomes (ulcer recurrence at 1 year, dehiscence, seroma, cellulitis) were collected...
May 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29765819/complications-in-salvage-surgery-for-nasal-and-paranasal-malignant-tumors-involving-the-skull-base
#4
Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Hidehito Kimura, Masaaki Taniguchi, Kazunobu Hashikawa, Eiji Kohmura, Ken-Ichi Nibu
Objective  Nasal and paranasal malignant tumors invading the skull base are rare and poorly studied. We evaluated postoperative complications in patients undergoing salvage surgery for such tumors. Design  Retrospective study. Setting  Kobe University Hospital. Participants  Among 48 patients who underwent surgery for tumors involving the skull base between 1993 and 2015, 21 patients had squamous cell carcinoma, 13 had olfactory neuroblastoma, 5 had adenocarcinoma, 2 had sarcoma, 2 had adenoid cystic carcinoma, and 1 each had malignant melanoma, poorly differentiated carcinoma, undifferentiated carcinoma, myoepithelial carcinoma, and malignant peripheral nerve sheath tumor...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29762451/modified-design-of-anterolateral-thigh-flap-for-total-pharyngolaryngectomy-reconstruction-a-single-center-experience
#5
Li-Yen Cheng, Cha-Chun Chen, Hwang-Chi Lin, Chu-Hsu Jeng, Shang-Hsi Lin, Wei-Nung Jim Chen, Yu-Hsien Lin, Sheng-Po Hao
BACKGROUND: Defects after total pharyngolaryngectomy for hypopharyngeal cancer often require reconstruction via free tissue transfer. Recently, anterolateral thigh (ALT) flap has become the gold standard in many centers because of its advantages with respect to versatility, minimal donor-site morbidity, good speech quality, and relatively low fistula and anastomotic leakage rates. Moreover, ALT allows 2 surgical teams to work simultaneously. However, the height of the parallelogram in the ALT design for neoesophagus reconstruction is usually set at a minimum of 9...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29762447/gastrocnemius-myocutaneous-flaps-for-knee-joint-coverage
#6
Alice Mayoly, Jean-Camille Mattei, Pierre Moullot, Charlotte Jaloux, Alexandre Rochwerger, Dominique Casanova, Baptiste Bertrand, Cécile Philandrianos
INTRODUCTION: The gastrocnemius muscular flap has already proven its efficiency for soft tissue coverage in cases of knee joint exposure. However, it may be too small to cover large defects and has not the same aesthetic and mechanical properties as normal skin. Perforator fasciocutaneous flaps have recently been described in knee joint coverage with good results as they replace skin by skin, but they can be hard to harvest. Gastrocnemius flaps can be easily harvested with a planned skin paddle designed over the chosen muscle...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29762440/reconstruction-of-extensive-post-electric-burn-scalp-defects-with-exposed-bones-a-study-of-12-cases
#7
Periakaruppan Jeyakumar, Alia T Hussain, Ashik R Ahamed
The scalp is a unique part of the human body with respect to its shape and position. It is the part of the body that is usually exposed in its original form, with no covering by any means of clothing. In workplaces, especially in the electrical industry in the area of electrical substations and power transmission lines it is this part of the body that can easily come in contact with high tension electrical wires. Others who can be prone to suffer such injuries are pedestrians, people working on heights, ladies hanging clothes on terraces...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29762332/extended-release-liposomal-bupivacaine-injection-exparel-for-early-postoperative-pain-control-following-palatoplasty
#8
Kristopher M Day, Narayanan M Nair, Larry A Sargent
INTRODUCTION: Liposomal bupivacaine (LB) is a long-acting local anesthetic reported to decrease postoperative pain in adults. The authors demonstrate the safe use of LB in pediatric patients with improved pain control following palatoplasty. MATERIALS AND METHODS: Retrospective patient series of all single-surgeon palatoplasty patients treated at a tertiary craniofacial center from August 2014 to December 2015 were included. All patients received 1.3% LB intraoperatively as greater palatal nerve and surgical field blocks in 2-flap V-Y pushback palatoplasty...
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29761502/efficacy-of-tunnel-technique-in-the-treatment-of-localized-and-multiple-gingival-recessions-a-systematic-review-and-a-meta-analysis
#9
REVIEW
Lorenzo Tavelli, Shayan Barootchi, Trang V N Nguyen, Mustafa Tattan, Andrea Ravidà, Hom-Lay Wang
BACKGROUND: Tunnel technique (TUN) has recently gained popularity among clinicians for its promising clinical and esthetic results when treating gingival recessions (GRs) defects. However, the evidence of the efficacy of TUN in the literature is still to be determined. Therefore, the aim of the present systematic review and meta-analysis was to investigate the predictability of TUN and its comparison to coronally advanced flap (CAF) procedure. MATERIAL AND METHODS: A literature search on PubMed, Cochrane libraries, EMBASE, and hand-searched journals until November 2017 was conducted to identify clinical studies investigating TUN for root coverage procedures...
May 14, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29756302/velopharyngeal-dysfunction-from-intranasal-substance-abuse-case-series-and-review-of-literature
#10
Peng You, Linda Chow, Anne Dworschak-Stokan, Murad Husein
OBJECTIVE: Intranasal substance abuse with cocaine or opioids can result in complications involving the midline nasal and oral structures. When the defect involves the velopharyngeal musculature, this leads to velopharyngeal dysfunction (VPD). This article aims to illustrate this clinical entity through a series of four patients and a review of the literature. METHODS: A series of four cases of VPD due to intranasal narcotic use and their management are discussed...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29752746/anti-resorptive-effect-of-pamidronate-on-extraction-socket-wall-in-dogs
#11
Jae-Kook Cha, Yoo-Kyung Sun, Myong Ji Kim, Mariano Sanz, Ui-Won Jung
AIM: The aim of this experimental in vivo investigation was to assess the anti-resorptive effect of low concentration pamidronate on the buccal plate in fresh extraction sockets. MATERIALS AND METHODS: The distal roots of the third premolars were extracted bilaterally in six dogs. A collagen matrix loaded with either pamidronate (test group) or saline (control group) was positioned on the outer surface of buccal bone immediately after tooth extraction and subsequently covered with a coronally advanced flap...
May 12, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29750760/prospective-randomized-controlled-comparison-of-local-anesthetic-infusion-pump-versus-depofoam-bupivacaine-for-pain-management-after-unilateral-delayed-deep-inferior-epigastric-perforator-free-flap-reconstruction
#12
James Gatherwright, Rebecca Knackstedt, Amir Ghaznavi, Steven Bernard, Graham Schwarz, Andrea Moreira, Raffi Gurunluoglu, Risal Djohan
BACKGROUND: Effective postsurgical analgesia is a critical aspect of patient recovery. The goal of this prospective, randomized, controlled, blinded study was to examine the effect that liposomal bupivacaine delivered via a transversus abdominis plane (TAP) block has on pain control in women undergoing unilateral deep inferior epigastic perforator reconstruction. METHODS: IRB approval was granted for this prospective study. Patients were eligible if they were undergoing unilateral, delayed DIEP reconstruction...
March 15, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29750729/posterior-lamellar-reconstruction-of-the-lower-eyelid-with-a-gingivoalveolar-mucosal-graft
#13
Yahya Baltu
The anterior and posterior lamellae should be simultaneously reconstructed to repair the upper and lower eyelid's full thickness defects after resection of a malignant tumor. The author described a gingivoalveolar mucosal graft for posterior lamellar reconstruction of the lower eyelid. Between November 2014 and September 2017, 11 patients (6 women, 5 men; mean age 62.7 years) with 13 posterior lamellar defect of lower eyelid underwent reconstruction with gingivoalveolar mucosal graft. The defects ranged from 10 x 8 mm to 20 x 10 mm...
May 10, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29746279/free-style-capillary-perforator-based-island-flaps-for-reconstruction-of-skin-cancer-defects-of-the-face-body-and-extremities
#14
Giuseppe Visconti, Marzia Salgarello
BACKGROUND: The perforator flap concept has revolutionized reconstructive surgery. Recently, the attention has moved toward flaps based on capillary perforators, which have been usually neglected in the past as reliable perforators. The aim of this article is to report a series of freestyle capillary perforator-based island flap (c-PBIF) for reconstruction of skin cancer defects of the face, body, and extremities. PATIENTS AND METHODS: Between September 2015 and July 2017, 20 consecutive patients underwent c-PBIF reconstruction of facial, body, and limb defects after melanoma and nonmelanoma skin cancer excision...
April 30, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29746278/computed-tomographic-angiography-used-for-localization-of-the-cutaneous-perforators-and-selection-of-anterolateral-thigh-flap-bail-out-branches
#15
Anna K Steve, Colin P White, Ali Alkhawaji, Thomas E J Hayakawa, Edward W Buchel, Steven F Morris
BACKGROUND: The purpose of this study was to evaluate the territory supplied by the lateral circumflex femoral artery for the consistency of a proximal perforator that could be used as an alternative pedicle for the anterolateral thigh flap if a tedious intramuscular course is encountered during elevation of the perforator used to develop the initial surgical plan. It is hypothesized that a consistent "bail-out" perforator supplying the proximal thigh would facilitate a simpler anterolateral thigh flap harvest, with minimal modification to flap design...
April 30, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29746274/combined-autologous-and-prosthetic-breast-reconstruction-defining-the-upper-limits-of-safe-expansion-in-obesity
#16
Joshua H Choo, Thomas J Lee, Steven A Schulz, Mitchell Buller, Bradon J Wilhelmi
BACKGROUND: Combined latissimus dorsi and prosthetic reconstruction is a useful reconstructive option in patients with a history of breast radiation who are not good candidates for abdominally based autologous reconstruction. One difficulty, particularly in obese patients, is that the thickness of the flap can impair port localization, increasing the risk of inadvertent puncture during expansion. The authors sought to investigate the upper limits of tissue thickness at which tissue expansion can be reliably performed...
April 30, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29744524/-defect-coverage-using-gluteal-flaps
#17
REVIEW
T R Mett, M K Boyce, R Ipaktchi, P M Vogt
OBJECTIVE: Gluteal skin, fasciocutaneous and myocutaneous flaps can be used to cover decubitus ulcers in the sacral and ischiocrural area. INDICATIONS: Decubitus ulcers in the sacral or ischial area that do not heal after exhausted conservative therapy. CONTRAINDICATIONS: Moribund patients who are very likely to suffer a life-threatening complication. Non-cooperative patients who cannot follow the postoperative recommendations. The presence of extensive scars after previous operations in the donor area or irradiation of the donor area which may compromise the flap perfusion...
May 9, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29738817/effect-of-antimicrobial-photodynamic-therapy-in-open-flap-debridement-in-the-treatment-of-peri-implantitis-a-randomized-controlled-trial
#18
Abdulaziz M Albaker, Aws S ArRejaie, Mohammed Alrabiah, Khulud Abdulrahman Al-Aali, Sameer Mokeem, Mohammed N Alasqah, Fahim Vohra, Tariq Abduljabbar
BACKGROUND: To evaluate the effects of single application of antimicrobial photodynamic therapy (aPDT) as an adjunct to open flap debridement (OFD) and OFD alone in patients with peri-implantitis (PI). MATERIALS AND METHODS: Twenty four patients with PI were divided into 2 groups receiving aPDT with OFD and OFD alone respectively. Peri-implant plaque index (PI), bleeding on probing (BOP), pocket depth (PD) and marginal bone level (MBL) were assessed at baseline, 6 and 12 months post-therapy...
May 5, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29735403/proteins-of-the-retinoblastoma-pathway-fen1-and-mgmt-are-novel-potential-prognostic-biomarkers-in-pancreatic-adenocarcinoma
#19
Joel Isohookana, Kirsi-Maria Haapasaari, Ylermi Soini, Joni Leppänen, Peeter Karihtala
BACKGROUND: We studied the expression of some major proteins involved in cell-cycle regulation and DNA repair, the roles of which are not well known in pancreatic ductal adenocarcinoma (PDAC), but which have a significant impact on carcinogenesis of many other cancers. METHODS: We immunohistochemically assessed expression levels of the cell-cycle regulators Rb1, p16 and cyclin-dependent kinase 4 (CDK4), and the DNA repair enzymes O6-methylguanine-DNA-alkyltransferase (MGMT) and flap endonuclease-1 (FEN1) separately in malignant tissue and benign tissue from resection margins in 102 cases of PDAC...
May 1, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29734459/-application-of-vacuum-wound-therapy-with-split-thickness-skin-grafts-in-the-head-and-neck-area
#20
Julia Thierauf, Paul Severin Wiggenhauser, Thomas Karl Hoffmann, Jens Greve, Marc Scheithauer, Johannes Adrian Veit
OBJECTIVE: In vacuum wound therapy (VAC) a negative pressure can continuously clean effusions and enhance the formation of granulation tissue significantly. In visceral, trauma and burns surgery this technique is used frequently in critical wounds. In the head and neck area there is limited experience and publications. Especially in the combined use of split-thickness-skin grafts (STSG) and VAC there is no published evidence. MATERIAL AND METHODS: A retrospective database analysis was done and resulted in 36 single VAC therapies in 13 patients...
May 7, 2018: Laryngo- Rhino- Otologie
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