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https://www.readbyqxmd.com/read/29912811/innovations-in-energy-expenditure-assessment
#1
Najate Achamrah, Taku Oshima, Laurence Genton
PURPOSE OF REVIEW: Optimal nutritional therapy has been associated with better clinical outcomes and requires providing energy as closed as possible to measured energy expenditure. We reviewed the current innovations in energy expenditure assessment in humans, focusing on indirect calorimetry and other new alternative methods. RECENT FINDINGS: Although considered the reference method to measure energy expenditure, the use of indirect calorimetry is currently limited by the lack of an adequate device...
June 15, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29909606/dietary-protein-and-nutritional-supplements-in-conventional-hemodialysis
#2
Alice Sabatino, Giovanni Piotti, Carmela Cosola, Ilaria Gandolfini, Jeroen P Kooman, Enrico Fiaccadori
Protein energy wasting (PEW) is a condition commonly occurring among patients with ESRD on hemodialysis. PEW is characterized by depletion of protein and energy stores and is caused by multiple factors related to chronic kidney disease, acute and chronic comorbidities and by renal replacement therapy itself. Anorexia is central in the pathogenesis of PEW; it is frequently observed in these patients whose protein and energy intakes are typically lower than guidelines recommendations. If untreated, PEW invariably leads to major complications, and may activate a vicious circle with further worsening of nutritional status...
June 17, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29908686/advanced-practice-nursing-nutrition-nurse-specialist-role-and-function
#3
Kurt Boeykens, Ann Van Hecke
BACKGROUND: Different disciplines should be represented in Nutritional Support Teams, e.g. a physician, dietician, pharmacist and a nurse. The latter one can function as an Advanced Practice Nurse, which implicates that he or she must have sufficiently thorough knowledge, attitudes and competences to fulfill the profile of a nutritional expert in the field of clinical nutrition. METHODS: Description of the scope of practice, education and added value related to a Nutrition Support Nurse, based on detailed published competency profiles...
August 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29908683/determination-of-serum-bone-related-minerals-during-denosumab-treatment-in-osteoporosis-patients-with-rheumatoid-arthritis-mineral-change-by-denosumab-in-osteoporosis-with-rheumatoid-arthritis
#4
Takako Suzuki, Yukio Nakamura, Hiroyuki Kato
OBJECTIVES: This study included 51 osteoporosis patients with rheumatoid arthritis (RA) who were treated with anti-resorption drug, denosumab. To date, there has been no report on the changes of bone-related minerals after anti-resorption drug therapy. METHODS: Fifty one osteoporotic patients with RA were retrospectively enrolled. Serum Zinc (Zn), Magnesium (Mg), Iron (Fe), and Copper (Cu) were examined at 1 week, 1, 2, 4, 6, 8, 10, 12 months. Lumbar spine (L1-4) bone mineral density (L-BMD), and bilateral total hip BMD (H-BMD) were examined before and at 6 and 12 months after treatment commencement...
August 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29908680/interactions-between-dietary-inflammatory-index-nutritional-state-and-multiple-sclerosis-clinical-condition
#5
Bruna Yhang Da Costa Silva, Helena Alves De Carvalho Sampaio, Nitin Shivappa, James Hébert, Larissa Da Silva Albuquerque, Antônio Augusto Ferreira Carioca, José Artur Costa D'Almeida, Carla Soraya Costa Maia, Maria Luisa Pereira De Melo
BACKGROUND & AIMS: The Dietary Inflammatory Index (DII) consists of a tool that assesses dietary inflammatory potential based on the assignment of an inflammatory score to a variety of nutrients, seasonings and bioactive compounds. Pro-inflammatory diets are associated to weight and abdominal fat excess. High Body Mass Index (BMI) and Waist Circumference (WC) seem to contribute to a worse prognosis in Multiple Sclerosis (MS) patients. Therefore, this study seeks to investigate the relation between anthropometric indexes and body adiposity with the clinical condition and the Dietary Inflammatory Index of MS individuals...
August 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29908678/nutritional-practices-and-adequacy-in-children-supported-on-extracorporeal-membrane-oxygenation
#6
Chengsi Ong, Yee Hui Mok, Zhen Han Tan, Carey Y S Lim, Bixia Ang, Teng Hong Tan, Yee Jim Loh, Yoke Hwee Chan, Jan Hau Lee
BACKGROUND AND AIMS: Use of extracorporeal membrane oxygenation (ECMO) in children is increasing. Yet, little is known about optimal nutritional practices in these children. We aim to describe the nutritional adequacy, factors associated with enteral nutrition, and the association between nutritional adequacy and mortality in children supported on ECMO. METHODS: We conducted a retrospective review of all children (1 month-18 years) requiring ECMO between 2010 and 2016...
August 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29907100/demand-for-integrative-medicine-among-women-in-pregnancy-and-childbed-a-german-survey-on-patients-needs
#7
Nikolas Schürger, Evelyn Klein, Alexander Hapfelmeier, Marion Kiechle, Daniela Paepke
BACKGROUND: Although integrative medicine is gaining increasing attention and is claiming more and more its place in modern health care, it still plays a marginal role in conventional maternity care. The present study aims to examine the patterns of Complementary and Alternative Medicine (CAM) use and the demand for integrative therapies, including CAM, relaxation therapies, nutritional counseling, and psychological assistance, among women in pregnancy and childbed. METHODS: The survey was conducted from April 2017 to July 2017 by means of a pseudo-anonymous 38-item questionnaire at the Department of Gynecology and Obstetrics, Klinikum rechts der Isar, Technical University of Munich...
June 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29906810/endoscopic-gastric-reduction-with-an-endoluminal-suturing-device-a-multicenter-prospective-trial-with-1-year-follow-up
#8
Vincent Huberty, Evzen Machytka, Ivo Boškoski, Marie Barea, Guido Costamagna, Jacques Deviere
BACKGROUND:  Obesity is the pandemic disease of this century. Surgery is the only effective treatment but cannot be offered to every patient. Endoscopic sutured gastroplasty is a minimally invasive technique that may potentially fill the gap between surgery and behavioral therapy. In this study, we prospectively investigated the efficacy and safety of a novel suturing device. METHODS:  After a pre-bariatric multidisciplinary work-up, class 1 and 2 obese patients were included...
June 15, 2018: Endoscopy
https://www.readbyqxmd.com/read/29906312/successful-treatment-of-chronic-hepatitis-c-infection-with-crushed-elbasvir-grazoprevir-administered-via-a-percutaneous-endoscopic-gastrostomy-tube
#9
J E Yap, P Jaiswal, L Ton, R Szynkarek, B M Attar, S Gandhi
WHAT IS KNOWN AND OBJECTIVE: Elbasvir/grazoprevir is an all-oral regimen approved for patients with hepatitis C virus (HCV) genotypes 1 and 4, and in renal insufficiency. However, to date, no data exist on the efficacy of this regimen when it is crushed and administered through a percutaneous endoscopic gastrostomy (PEG) tube. Here, we illustrate the case of a 63-year-old man who is the only known patient with HCV infection in the English literature to have successfully achieved a sustained viral response (SVR) when elbasvir/grazoprevir oral combination was administered through a PEG tube...
June 15, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29901462/changing-paradigms-in-metabolic-support-and-nutrition-therapy-during-critical-illness
#10
Arthur R H van Zanten
PURPOSE OF REVIEW: To summarize the most recent advances in acute metabolic care and critical care nutrition. RECENT FINDINGS: Recent research has demonstrated unknown consequences of high protein and amino acid administration in the early phase of ICU stay associated with dysregulated glucagon release leading to hepatic amino acid breakdown and suggested adverse effects on autophagy and long-term outcome. Progress has been made to measure body composition in the ICU...
June 8, 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29901461/refeeding-syndrome-relevance-for-the-critically-ill-patient
#11
Rianne Boot, Kristine W A C Koekkoek, Arthur R H van Zanten
PURPOSE OF REVIEW: To provide an overview of recent findings concerning refeeding syndrome (RFS) among critically ill patients and recommendations for daily practice. RECENT FINDINGS: Recent literature shows that RFS is common among critically ill ventilated patients. Usual risk factors for non-ICU patients addressed on ICU admission do not identify patients developing RFS. A marked drop of phosphate levels (>0.16 mmol/l) from normal levels within 72 h of commencement of feeding, selects patients that benefit from hypocaloric or restricted caloric intake for at least 48 h resulting in lower long-term mortality...
June 8, 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29901086/exclusive-enteral-nutrition-protects-against-inflammatory-bowel-disease-by-inhibiting-nf%C3%A2-%C3%AE%C2%BAb-activation-through-regulation-of-the-p38-msk1-pathway
#12
Ting Yu, Qian Yu, Xiaotian Chen, Lixing Zhou, Yuming Wang, Chenggong Yu
Although enteral nutrition therapy for inflammatory bowel disease has been confirmed to be an effective treatment method, the exact mechanism responsible for the effects of enteral nutrition remains unclear. The aim of the present study was to investigate the protective effect of exclusive enteral nutrition (EEN) against colitis, and to elucidate the potential mechanisms by inhibiting p65 activation via regulating the p38/mitogen‑ and stress‑activated protein kinase‑1 (MSK1) pathway. Experiments were performed by establishing dextran sulfate sodium (DSS)‑mice colitis and picrylsulfonic acid solution (TNBS)‑induced rat colitis, and the results demonstrated that EEN treatment attenuated body weight loss, colon length shortening and colonic pathological damage caused by colitis...
June 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29899663/albumin-globulin-ratio-is-negatively-correlated-with-pd-1-and-cd25-mrna-levels-in-breast-cancer-patients
#13
Chao Liu, Wei Wang, Xiangying Meng, Bing Sun, Yang Cong, Jiannan Liu, Qian Wang, Guangxian Liu, Shikai Wu
Background: Previous studies have demonstrated the prognostic value of globulin (GLB), albumin (ALB), the ALB/GLB ratio (AGR), body mass index (BMI), hemoglobin (Hb), and prognostic nutritional index (PNI) in breast cancer. The underlying mechanism has been investigated by examining the impact of nutritional parameters on T cells, natural killer cells, and dendritic cells, but little is known about their effect on checkpoint molecules. Methods: Here, we investigated the correlation of mRNA expression of programmed cell death protein 1 (PD-1), cluster of differentiation 28 (CD28), cytotoxic T-lymphocyte antigen-4 (CTLA-4), and cluster of differentiation 25 (CD25) with AGR, ALB, GLB, total protein, pre-ALB, Hb, BMI, and PNI in the peripheral blood of breast cancer patients...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29899304/validation-of-different-nutritional-assessment-tools-in-predicting-prognosis-of-patients-with-soft-tissue-spindle-cell-sarcomas
#14
Hiromi Sasaki, Satoshi Nagano, Setsuro Komiya, Noboru Taniguchi, Takao Setoguchi
Predicting outcomes in patients with soft tissue sarcoma (STS) is challenging. To improve these predictions, we retrospectively analyzed common nutritional assessment systems, including Glasgow prognostic score (GPS), Geriatric Nutritional Risk Index (GNRI), neutrophil⁻lymphocyte ratio (NLR), platelet⁻lymphocyte ratio (PLR), and controlling nutritional (CONUT) score against outcomes in 103 patients with STS, of whom 15 (14.6%) died within 1 year of diagnosis. GPS, GNRI, NLR, PLR, and CONUT scores significantly differed between patients who died within one year and patients who lived longer...
June 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29898649/bpc157-as-potential-agent-rescuing-from-cancer-cachexia
#15
Eun A Kang, Young Min Han, Jeong Min An, Yong Jin Park, Predrag Sikiric, Deok Hwan Kim, Kwang An Kwon, Yoon Jae Kim, Donghwa Yang, Hann Tchah, Ki Baik Hahm
Cancer cachexia, one of the metabolic syndromes caused by cancer, is a devastating and miserable condition encountered in more than 50% of terminal cancer patients presenting with significant weight loss associated with skeletal muscle atrophy and fat loss. Though cachexia may account for up to 20% of cancer deaths, no significant treatment is still lacking and is of urgent unmet medical need in cancer treatment. Therefore, understanding the underlying molecular mechanisms is essential for anticipating therapeutic approaches...
June 13, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29898488/-diet-in-chronic-kidney-disease-a-practical-guide
#16
Stephan C Bischoff, Maryam Basrai
Chronic kidney disease is associated with metabolic disorders. The nutrient requirement varies considerably and often it is not covered. This is why many patients experience severe deficiencies ("kidney disease wasting"), which limits their quality of life and prognosis. On the other hand sodium, potassium and phosphate must be limited. Nutritional therapy is a relevant part of the therapy.
June 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29897291/isoniazid-induced-neuropathy-in-a-pre-pubertal-child
#17
Naman S Shetty, Ira Shah
Isoniazid (INH)-induced peripheral neuritis is not uncommonly reported in adults, especially those with malnutrition and alcoholism, but it is very rare in children. INH leads to peripheral neuritis by causing a deficiency in the serum level of pyridoxine which depends on the dose of INH, duration of treatment and the patient's nutritional and acetylator status. A 12-year-old girl developed tingling and numbness of the lower limbs after commencing anti-tuberculous therapy which included INH 10 mg/kg/day. The symptoms continued despite the dose being reduced to 5 mg/kg/day...
June 13, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29896658/generation-of-transplantable-retinal-pigmented-epithelial-rpe-cells-for-treatment-of-age-related-macular-degeneration-amd
#18
Harshini Surendran, Reena J Rathod, Rajarshi Pal
Age-related macular degeneration (AMD) is the foremost cause of blindness in people over the age of 60 worldwide. Clinically, this disease starts with distortion in central vision eventually leading to legal blindness. Vision loss has a significant impact on quality of life and incurs a substantial cost to the economy. Furthermore, AMD is a complex and progressive neurodegenerative disorder that triggers visual impairment due to the loss of retinal pigmented epithelium (RPE) and the light-sensitive photoreceptors that they support, protect and provide nutrition...
June 13, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29894558/interventions-for-preventing-distal-intestinal-obstruction-syndrome-dios-in-cystic-fibrosis
#19
REVIEW
Jessica Green, Francis J Gilchrist, Will Carroll
BACKGROUND: Cystic fibrosis (CF) is the most common, life-limiting, genetically inherited disease. It affects multiple organs, particularly the respiratory system. However, gastrointestinal problems such as constipation and distal intestinal obstruction syndrome (DIOS) are also important and well-recognised complications in CF. They share similar symptoms e.g. bloating, abdominal pain, but are distinct conditions. Constipation occurs when there is gradual faecal impaction of the colon, but DIOS occurs when there is an accumulation of faeces and sticky mucus, forming a mass in the distal part of the small intestine...
June 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29893038/patient-information-needs-in-upper-gastrointestinal-cancer-what-patients-and-their-families-want-to-know
#20
REVIEW
Bacil Otutaha, Sanket Srinivasa, Jonathan Koea
BACKGROUND: The treatment of upper gastrointestinal cancer (UGIC) patients is complex. Patients are often elderly, comorbid as well as nutritionally depleted and treatment involves multimodality therapy incorporating chemotherapy, radiation therapy and surgery. The pre-treatment information requirements of UGIC patients are not clear but crucially important in ensuring they complete treatment successfully. METHODS: A systematic review of the English language literature was performed to determine the specific information needs of patients with UGIC...
June 11, 2018: ANZ Journal of Surgery
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