keyword
https://read.qxmd.com/read/38494524/prediction-of-compressive-strength-of-concrete-based-on-improved-artificial-bee-colony-multilayer-perceptron-algorithm
#21
JOURNAL ARTICLE
Ping Li, Yanru Zhang, Jiming Gu, Shiwei Duan
There are many factors that affect the compressive strength of concrete. The relationship between compressive strength and these factors is a complex nonlinear problem. Empirical formulas commonly used to predict the compressive strength of concrete are based on summarizing experimental data of several different mix proportions and curing periods, and their generality is poor. This article proposes an improved artificial bee colony algorithm (IABC) and a multilayer perceptron (MLP) coupled model for predicting the compressive strength of concrete...
March 17, 2024: Scientific Reports
https://read.qxmd.com/read/38494238/preparation-of-an-injectable-and-photocurable-carboxymethyl-cellulose-hydroxyapatite-composite-and-its-application-in-cranial-regeneration
#22
JOURNAL ARTICLE
He Qiu, Jing Wang, Hong Hu, Lu Song, Zhanhong Liu, Yang Xu, Shuo Liu, Xiangdong Zhu, Hang Wang, Chongyun Bao, Hai Lin
Limited bone regeneration, uncontrollable degradation rate, mismatched defect zone and poor operability have plagued the reconstruction of irregular bone defect by tissue-engineered materials. A combination of biomimetic scaffolds with hydroxyapatite has gained great popularity in promoting bone regeneration. Therefore, we designed an injectable, photocurable and in-situ curing hydrogel by methacrylic anhydride -modified carboxymethyl cellulose (CMC-MA) loading with spherical hydroxyapatite (HA) to highly simulate the natural bony matrix and match any shape of damaged tissue...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38493551/mesh-less-laparoscopic-extraperitoneal-linear-suspension-treatment-of-vaginal-vault-prolapse
#23
JOURNAL ARTICLE
Wenhui Wang, Haiyan Liang, Huan Yu, Chunhong Rong, Yuxiao Dong, Ming Xue, Xiaodie Liu, Jing Liang, Bin Ling
OBJECTIVES: To report the results of a mesh-less laparoscopic extraperitoneal linear suspension technique for the treatment of post-hysterectomy vaginal vault prolapse (PHVP). STUDY DESIGN: A retrospective observational study was conducted collecting medical records of 41 patients with symptomatic PHVP treated between November 2017 to November 2019 in Gynecologic department of China-Japan Friendship Hospital. All patients had Pelvic Organ Prolapse Quantification (POP-Q) scores indicating stage 3-4 PHVP and underwent mesh-less laparoscopic extraperitoneal linear suspension...
February 23, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38493059/soho-state-of-the-art-updates-and-next-questions-treatment-evolution-of-mantle-cell-lymphoma-navigating-the-different-entities-and-biological-heterogeneity-of-mantle-cell-lymphoma-in-2024
#24
REVIEW
Andrew Ip, Alexandra Della Pia, Andre H Goy
Progress in mantle cell lymphoma (MCL) has led to significant improvement in outcomes of patients even in the real world (RW) setting albeit to a lesser degree. In parallel to the demonstration of benefit using combination therapy with rituximab plus high-dose cytarabine (R-AraC) as well as dose intensive therapy-autologous stem cell transplantation (DIT-ASCT) consolidation and maintenance, it became clear over the last 2 decades that MCL is a highly heterogenous disease at the molecular level, explaining differences observed in clinical behavior and response to therapy...
February 22, 2024: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/38493037/efficacy-and-safety-of-fundoplication-in-treating-gastroesophageal-reflux-related-chronic-cough-a-meta-analysis
#25
REVIEW
Jiannan Liu, Zhiwei Hu, Yan Liang, Shurui Tian, Jimin Wu
Gastroesophageal reflux related chronic cough (GERC), is a common type of chronic cough. Drug treatment is the first choice. But some patients are tired of taking medicine everyday and some patients can not benefit from drugs. For these patients, fundoplication may be the most effective method. However, the importance of fundoplication in treating GERC is undervalued, and there is very few meta-analysis looking into the effect and safety of fundoplication in treating GERC. To solve this question, we performed this meta-analysis...
March 15, 2024: Asian Journal of Surgery
https://read.qxmd.com/read/38493007/revolutionising-healing-gene-editing-s-breakthrough-against-sickle-cell-disease
#26
REVIEW
Marija Dimitrievska, Dravie Bansal, Marta Vitale, John Strouboulis, Annarita Miccio, Kypros H Nicolaides, Sara El Hoss, Panicos Shangaris, Joanna Jacków-Malinowska
Recent advancements in gene editing illuminate new potential therapeutic approaches for Sickle Cell Disease (SCD), a debilitating monogenic disorder caused by a point mutation in the β-globin gene. Despite the availability of several FDA-approved medications for symptomatic relief, allogeneic hematopoietic stem cell transplantation (HSCT) remains the sole curative option, underscoring a persistent need for novel treatments. This review delves into the growing field of gene editing, particularly the extensive research focused on curing haemoglobinopathies like SCD...
March 7, 2024: Blood Reviews
https://read.qxmd.com/read/38492895/olfactory-ensheathing-cells-as-candidate-cells-for-chronic-pain-treatment
#27
REVIEW
Mei-Chen Liu, Qing-Fa Guo, Wei-Wei Zhang, Hong-Liang Luo, Wen-Jun Zhang, Hai-Jun Hu
Chronic pain is often accompanied by tissue damage and pain hypersensitivity. It easily relapses and is challenging to cure, which seriously affects the patients' quality of life and is an urgent problem to be solved. Current treatment methods primarily rely on morphine drugs, which do not address the underlying nerve injury and may cause adverse reactions. Therefore, in recent years, scientists have shifted their focus from chronic pain treatment to cell transplantation. This review describes the classification and mechanism of chronic pain through the introduction of the characteristics of olfactory ensheathing cells (OECs), an in-depth discussion of special glial cells through the phagocytosis of nerve debris, receptor-ligand interactions, providing nutrition, and other inhibition of neuroinflammation, and ultimately supporting axon regeneration and mitigation of chronic pain...
March 14, 2024: Journal of Chemical Neuroanatomy
https://read.qxmd.com/read/38492814/from-palliative-care-to-a-definite-cure-a-severe-presentation-of-whipple-disease
#28
JOURNAL ARTICLE
Margarida Rajão Saraiva, Daniel Conceição, Joana Lemos Garcia, Sara da Mata, João Pedro Caldeira, Pedro Currais, Carolina Simões
No abstract text is available yet for this article.
March 14, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38492519/new-perspective-of-small-molecule-antiviral-drugs-development-for-rna-viruses
#29
REVIEW
Shasha Li, Huixia Li, Ruiya Lian, Jingying Xie, Ruofei Feng
High variability and adaptability of RNA viruses allows them to spread between humans and animals, causing large-scale infectious diseases which seriously threat human and animal health and social development. At present, AIDS, viral hepatitis and other viral diseases with high incidence and low cure rate are still spreading around the world. The outbreaks of Ebola, Zika, dengue and in particular of the global pandemic of COVID-19 have presented serious challenges to the global public health system. The development of highly effective and broad-spectrum antiviral drugs is a substantial and urgent research subject to deal with the current RNA virus infection and the possible new viral infections in the future...
March 7, 2024: Virology
https://read.qxmd.com/read/38492438/ferroptosis-mechanisms-and-its-novel-potential-therapeutic-targets-for-dlbcl
#30
REVIEW
Wenxia Bian, Haoran Li, Yuhan Chen, Yanhua Yu, Guojie Lei, Xinyi Yang, Sainan Li, Xi Chen, Huanjuan Li, Jing Yang, Chen Yang, Yanchun Li, Yi Zhou
Diffuse large B-cell lymphoma (DLBCL), a heterogeneous lymphoid malignancy, poses a significant threat to human health. The standard therapeutic regimen for patients with DLBCL is rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), with a typical cure rate of 50-70%. However, some patients either relapse after complete remission (CR) or exhibit resistance to R-CHOP treatment. Therefore, novel therapeutic approaches are imperative for managing high-risk or refractory DLBCL. Ferroptosis is driven by iron-dependent phospholipid peroxidation, a process that relies on the transition metal iron, reactive oxygen species (ROS), and phospholipids containing polyunsaturated fatty acids-containing phospholipids (PUFA-PLs)...
March 15, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38492390/cesium-immobilization-of-high-ph-and-low-ph-belite-rich-cement-under-varying-temperature
#31
JOURNAL ARTICLE
Raju Sharma, Kunal Krishna Das, Salman Siddique, Jeong Gook Jang
Low-pH cement is being studied in radioactive waste repositories. The belite-rich cement (BRC) recently gained attention due to its higher CO2 sequestration and low pH attainment under carbonation exposure. Therefore, this study evaluated the effects of pH and temperature on cesium immobilization of BRC. High pH (12.6) and low pH (9.9) BRC were produced via air curing and carbonation treatment, respectively. The high and low pH BRC samples were placed in a leaching environment at 25 °C and 45 °C for 90 days...
March 8, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38492321/zinc-protoporphyrin-formation-in-nitrite-free-parma-ham-and-its-relationship-with-intrinsic-parameters-and-red-color-profile-of-processed-hams
#32
JOURNAL ARTICLE
Cristina Schivazappa, Nicoletta Simoncini, Anna Pinna, Angela Faccioli, Paolo Zambonelli, Roberta Virgili
A total of 134 fresh hams, assayed for Ferrochelatase (FeCH) activity and ultimate pH (pH48 ), were processed in compliance with the procedures established for PDO Parma ham and finally, analyzed for salt, moisture, Zinc Protoporphyrin IX (ZnPP), heme, iron and zinc contents, and proteolysis index (PI). The variation in ZnPP content was related to the intrinsic parameters of fresh and matured hams by a Partial Least Square Regression model. The most favorable factors on the formation of ZnPP were total iron content (representative of the initial hemoprotein content), and FeCH activity, demonstrating the main role played by these raw matter-specific predictors in the long matured dry-cured hams...
March 2, 2024: Meat Science
https://read.qxmd.com/read/38492292/application-of-ultrasound-treatment-in-pork-marination-effects-on-moisture-migration-and-microstructure
#33
JOURNAL ARTICLE
Lina Guo, Xinyan Zhang, Chen Hong, Ning Liu, Ningning Ouyang, Junlin Chen, Muthupandian Ashokkumar, Haile Ma
To better understanding the effects of ultrasonic marination on the porcine tissue, the moisture migration and microstructure were investigated in this study. Additionally, the acoustic field distribution was analysis using COMSOL Multiphysics. The low-filed NMR results demonstrated that ultrasonic curing induced a leftward shift in T21 and a rightward shift in T22 , accompanied by a significant reduction in A22 , thereby enhancing the water-holding capacity of pork. The SEM and TEM observation showed that the presence of larger interstitial gaps between muscle fibers facilitated the diffusion of NaCl...
March 5, 2024: Food Chemistry
https://read.qxmd.com/read/38492184/embodiment-and-regenerative-implants-a-proposal-for-entanglement
#34
JOURNAL ARTICLE
Manon van Daal, Anne-Floor J de Kanter, Karin R Jongsma, Annelien L Bredenoord, Nienke de Graeff
Regenerative Medicine promises to develop treatments to regrow healthy tissues and cure the physical body. One of the emerging developments within this field is regenerative implants, such as jawbone or heart valve implants, that can be broken down by the body and are gradually replaced with living tissue. Yet challenges for embodiment are to be expected, given that the implants are designed to integrate deeply into the tissue of the living body, so that implant and body become one. In this paper, we explore how regenerative implants may affect the embodied experience of implant recipients...
March 16, 2024: Medicine, Health Care, and Philosophy
https://read.qxmd.com/read/38492036/molecular-mechanisms-and-therapeutic-application-of-extracellular-vesicles-from-plants
#35
REVIEW
Fatemeh Azizi, Salva Kazemipour-Khabbazi, Stefania Raimondo, Razieh Dalirfardouei
Small extracellular vesicles (sEVs) isolated from animal sources are among the most investigated types of cell-free therapeutic tools to cure different diseases. sEVs have been isolated from a variety of sources, ranging from prokaryotes to animals and plants. Human-derived sEVs have many uses in pre- and clinical studies in medicine and drug delivery, while plant-derived EVs, also known as plant-derived nanovesicles (PDNVs), have not been widely investigated until the second decade of the 21st century. For the past five years, there has been a rapid rise in the use of plant EVs as a therapeutic tool due to the ease of massive production with high efficacy and yield of preparation...
March 16, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38491739/highly-sensitive-iontronic-pressure-sensor-with-side-by-side-package-based-on-alveoli-and-arch-structure
#36
JOURNAL ARTICLE
Zhi Ding, Weijian Li, Weidong Wang, Zhengqian Zhao, Ye Zhu, Baoyin Hou, Lijie Zhu, Ming Chen, Lufeng Che
Flexible pressure sensors play a significant role in wearable devices and electronic skin. Iontronic pressure sensors with high sensitivity, wide measurement range, and high resolution can meet requirements. Based on the significant deformation characteristics of alveoli to improve compressibility, and the ability of the arch to disperse vertical pressure into horizontal thrust to increase contact area, a graded hollow ball arch (GHBA) microstructure is proposed, greatly improving sensitivity. The fabrication of GHBA ingeniously employs a double-sided structure...
March 15, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38491558/clinical-course-of-nontuberculous-mycobacterial-pulmonary-disease-in-patients-with-rheumatoid-arthritis
#37
JOURNAL ARTICLE
Nakwon Kwak, Jinyoung Moon, Joong-Yub Kim, Jun Won Park, Jae-Joon Yim
OBJECTIVES: The impact of rheumatoid arthritis (RA) on nontuberculous mycobacterial pulmonary disease (NTM-PD) has not been well established. In this study, we investigated the clinical course of NTM-PD in patients with RA and the impact of RA on the prognosis of NTM-PD. METHODS: We analyzed patients who developed NTM-PD after being diagnosed with RA from January 2004 to August 2023 at a tertiary referral hospital in South Korea. The patient's baseline characteristics, clinical course, and prognosis were evaluated...
March 15, 2024: Advances in Rheumatology
https://read.qxmd.com/read/38491394/designer-cell-therapy-for-tissue-regeneration
#38
REVIEW
Noyuri Zama, Satoshi Toda
Cancer cell therapy, particularly chimeric antigen receptor (CAR) T-cell therapy for blood cancers, has emerged as a powerful new modality for cancer treatment. Therapeutic cells differ significantly from conventional drugs, such as small molecules and biologics, as they possess cellular information processing abilities to recognize and respond to abnormalities in the body. This capability enables the targeted delivery of therapeutic factors to specific locations and times. Various types of designer cells have been developed and tested to overcome the shortcomings of CAR T cells and expand their functions in the treatment of solid tumors...
March 15, 2024: Inflammation and Regeneration
https://read.qxmd.com/read/38491076/effect-of-sodium-hypochlorite-ethylenediaminetetraacetic-acid-and-dual-rinse-irrigation-on-dentin-adhesion-using-an-etch-and-rinse-or-self-etch-approach
#39
JOURNAL ARTICLE
Matej Par, Tobias Steffen, Selinay Dogan, Noah Walser, Tobias T Tauböck
The aim was to investigate the influence of endodontic irrigation solutions and protocols on the micro-tensile bond strength (μTBS) to dentin using an etch-and-rinse (ER) or self-etch (SE) adhesive approach. Eighty extracted human molars were ground to dentin. After pretreating for 27 min (21 min-3 min-3 min) with five different endodontic irrigation protocols (Group 1: NaOCl-EDTA-NaOCl; Group 2: NaOCl-NaOCl-EDTA; Group 3: NaOCl-NaCl-NaOCl; Group 4: Dual Rinse-Dual Rinse-Dual Rinse; Group 5: NaCl-NaCl-NaCl), an ER (Optibond FL, Kerr) or a SE (Clearfil SE Bond, Kuraray) adhesive system was applied...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490856/prostate-cancers-in-the-prostate-specific-antigen-interval-of-1-8-3-ng-ml-results-from-the-g%C3%A3-teborg-2-prostate-cancer-screening-trial
#40
JOURNAL ARTICLE
Fredrik Möller, Marianne Månsson, Jonas Wallström, Mikael Hellström, Jonas Hugosson, Rebecka Arnsrud Godtman
BACKGROUND: Magnetic resonance imaging (MRI) and targeted biopsies reduce overdiagnosis of prostate cancer (PC). It is uncertain how this strategy performs for low prostate-specific antigen (PSA) levels. OBJECTIVE: To investigate the Prostate Imaging Reporting and Data System (PI-RADS) distribution, frequency, and characteristics of screen-detected PC with PSA of 1.8-<3 ng/ml and 3-<10 ng/ml. DESIGN, SETTING, AND PARTICIPANTS: In the population-based Göteborg-2 screening study, 17974 men choose to participate by having a PSA test (2015-2020)...
March 14, 2024: European Urology
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