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https://www.readbyqxmd.com/read/29341969/pursuing-normality-reflections-on-cancer-survivorship-care-of-lymphoma-survivors
#1
Louise S Madsen, Charlotte Handberg
BACKGROUND: The present study explored the reflections on cancer survivorship care of lymphoma survivors in active treatment. Lymphoma survivors have survivorship care needs, yet their participation in cancer survivorship care programs is still reported as low. OBJECTIVE: The aim of this study was to understand the reflections on cancer survivorship care of lymphoma survivors to aid the future planning of cancer survivorship care and overcome barriers to participation...
January 16, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29341952/a-pharmacological-review-leptadenia-reticulata-wight-arn-jivanti-the-real-life-giving-plant
#2
Jayesh M Dhalani, Pankaj B Nariya
The present review reveals a comprehensive description of various pharmacological studies carried out on Leptadenia reticulata, a source of several active compounds, i.e. Leptadenia reticulata plant belonging to family Asclepiadaceae, it is also known as 'Jivanti', used for the treatment of various ailments in human civilization as well as used in folk medicine as a remedy in various reported herbal formulations. The plant has been found to exhibit diverse pharmacological activities like antibacterial activity, anticancer activity, lactogenic eff ect, antioxidant activity, anti-implantation activity, anti-asthmatic activity, modulating eff ect, activity of silver nano particles, hepatoprotective activity, antifungal activity, antidiabetic activity and anti-infl ammatory activity...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29341393/prognostic-and-therapeutic-factors-influencing-the-clinical-outcome-of-hepatoblastoma-after-liver-transplantation-a-single-institute-experience
#3
Katsutsugu Umeda, Hideaki Okajima, Koji Kawaguchi, Seishiro Nodomi, Satoshi Saida, Itaru Kato, Hidefumi Hiramatsu, Eri Ogawa, Atsushi Yoshizawa, Shinya Okamoto, Shinji Uemoto, Kenichiro Watanabe, Souichi Adachi
LT has contributed to an elevation in cure rates for patients with unresectable HB; however, patients with recurrent HB after LT have poor prognosis. To analyze the prognostic and therapeutic factors that influence the clinical outcome of patients with HB receiving LT, we retrospectively analyzed 24 patients with HB who underwent LT between 1997 and 2015. The 5-year OS rate of all patients was 69.6±9.7%. The 5-year OS rate of 11 patients receiving salvage LT for recurrent tumor after a primary resection was comparable to that of 13 patients receiving primary LT...
January 17, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29341267/cross-linking-of-thiolated-paclitaxel-oligo-p-phenylene-vinylene-conjugates-aggregates-inside-tumor-cells-leads-to-chemical-locks-that-increase-drug-efficacy
#4
Lingyun Zhou, Fengting Lv, Libing Liu, Guizhi Shen, Xuehai Yan, Guillermo C Bazan, Shu Wang
How to reduce the resistance of certain tumor cells to paclitaxel (PTX) and related taxoid anticancer drugs is a major challenge for improving cure rates. An oligo(p-phenylenevinylene) unit with thiol groups and a PTX unit (OPV-S-PTX), which enhances drug efficacy and reverses resistance is thus designed. The mechanism involves diffusion of OPV-S-PTX into the cell, where π-π interactions lead to aggregation. Cross-linking of the aggregates via oxidation of thiol groups is favored in tumor cells because of the higher reactive oxygen species (ROS) concentration...
January 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29341265/cicatricial-alopecia-research-foundation-meeting-may-2016-progress-towards-the-diagnosis-treatment-and-cure-of-primary-cicatricial-alopecias
#5
John P Sundberg, Maria K Hordinsky, Wilma Bergfeld, Yolanda M Lenzy, Amy J McMichael, Angela M Christiano, Tracy McGregor, Kurt S Stenn, Raja K Sivamani, C Herbert Pratt, Lloyd E King
Primary Cicatricial Alopecias (PCAs) are a group of skin diseases in which there is progressive and permanent destruction of hair follicles followed by replacement with fibrous tissue. Unfortunately, by the time patients seek clinical evaluation of their hair loss, the skin is already inflamed and/or scarred, so there is little hope for a return to their normal hair growth pattern. Clinical and basic science investigations are now focusing on three forms of human PCA, lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and central centrifugal cicatricial alopecia (CCCA)...
January 16, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29341224/comparative-rna-seq-transcriptome-analysis-on-silica-induced-pulmonary-inflammation-and-fibrosis-in-mice-silicosis-model
#6
Jiayi Chen, Yuqin Yao, Xiaolan Su, Ying Shi, Xuejiao Song, Linshen Xie, Jia You, Liantian Tian, Luo Yang, Aiping Fang, Jingyuan Xiong
Silicosis is a long-established public health issue in developing countries due to increasingly serious air pollution and poorly implemented occupational safety regulation. Inhalation of silica triggers cytotoxicity, oxidative stress, pulmonary inflammation and eventually silicosis. Current understanding in the pathogenesis and mechanism of silicosis is limited, and no effective cure is clinically available once silicosis is developed. A number of studies were conducted to investigate silica-induced alternate gene expressions in pulmonary cells...
January 16, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29341205/promotion-time-cure-rate-model-with-nonparametric-form-of-covariate-effects
#7
Tianlei Chen, Pang Du
Survival data with a cured portion are commonly seen in clinical trials. Motivated from a biological interpretation of cancer metastasis, promotion time cure model is a popular alternative to the mixture cure rate model for analyzing such data. The existing promotion cure models all assume a restrictive parametric form of covariate effects, which can be incorrectly specified especially at the exploratory stage. In this paper, we propose a nonparametric approach to modeling the covariate effects under the framework of promotion time cure model...
January 17, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29341202/risk-factors-for-stress-urinary-incontinence-recurrence-after-single-incision-sling
#8
Stefania Palmieri, Matteo Frigerio, Federico Spelzini, Stefano Manodoro, Rodolfo Milani
AIMS: The aim of the study was to identify in a pure stress urinary incontinence (SUI) population risk factors for recurrence after single-incision slings (SIS). METHODS: This retrospective study analyzed women with complaints of SUI symptoms and urodynamically proven SUI. Exclusion criteria were recurrent SUI, overactive bladder syndrome/detrusor overactivity, preoperative postvoid residual >100 mL, reduced urethral mobility (<10° at the Q-tip test), concomitant anterior prolapse >I stage and previous history of radical pelvic surgery...
January 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29341162/impact-of-genomics-on-the-surgical-management-of-melanoma
#9
REVIEW
P M Ferguson, G V Long, R A Scolyer, J F Thompson
BACKGROUND: Although surgery for early-stage melanoma offers the best chance of cure, recent advances in molecular medicine have revolutionized the management of late-stage melanoma, leading to significant improvements in clinical outcomes. Research into the genomic drivers of disease and cancer immunology has not only ushered in a new era of targeted and immune-based therapies for patients with metastatic melanoma, but has also provided new tools for monitoring disease recurrence and selecting therapeutic strategies...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29340872/abstracts-of-the-2017-a-cure-symposium
#10
(no author information available yet)
No abstract text is available yet for this article.
January 16, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29340576/association-of-national-institute-of-child-health-and-human-development-career-development-awards-with-subsequent-research-project-grant-funding
#11
Dennis A Twombly, Sarah L Glavin, Jennifer Guimond, Susan Taymans, Catherine Y Spong, Diana W Bianchi
Importance: Investing in the next generation of researchers is essential, as recently highlighted in the 21st Century Cures Act. From its inception, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has supported training and career development to ensure a robust pipeline of investigators who are prepared to lead their respective fields of inquiry. In recent years, the NICHD has emphasized institutional over individual training awards to a greater degree than many other National Institutes of Health institutes of similar size...
January 16, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29340492/evaluation-of-the-impact-that-the-changes-in-tuberculosis-treatment-implemented-in-brazil-in-2009-have-had-on-disease-control-in-the-country
#12
Marcelo Fouad Rabahi, José Laerte Rodrigues da Silva Júnior, Marcus Barreto Conde
OBJECTIVE: To analyze the impact that the 2009 changes in tuberculosis treatment in Brazil had on the rates of cure, tuberculosis recurrence, mortality, treatment abandonment, and multidrug-resistant tuberculosis (MDR-TB). METHODS: An ordinary least squares regression model was used in order to perform an interrupted time series analysis of secondary data collected from the Brazilian Tuberculosis Case Registry Database for the period between January of 2003 and December of 2014...
November 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29339530/management-of-endocrine-disease-personalized-medicine-in-the-treatment-of-acromegaly
#13
Leandro Kasuki, Luiz Eduardo Wildemberg, Monica R Gadelha
Acromegaly is associated with high morbidity and elevated mortality when not adequately treated. Surgery is the first-line treatment for most patients as it is the only one that can lead to immediate cure. In patients who are not cured by surgery, treatment is currently based on a trial-and-error approach. First-generation somatostatin receptor ligands (fg-SRL) are initiated for most patients, although approximately 25% of patients present resistance to this drug class. Some biomarkers of treatment outcome are described in the literature, with the aim of categorizing patients into different groups to individualize their treatments using a personalized approach...
January 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29339395/efficacy-and-safety-of-finafloxacin-versus-ciprofloxacin-in-the-treatment-of-complicated-urinary-tract-infections-an-explorative-randomized-phase-ii-clinical-study
#14
F Wagenlehner, M Nowicki, C Bentley, M Lückermann, S Wohlert, C Fischer, A Vente, K Naber, A Dalhoff
INTRODUCTION: The broad spectrum C-8-cyano-fluoroquinolone finafloxacin displays enhanced activity at acidic conditions. This phase II clinical study compared efficacy and safety of finafloxacin and ciprofloxacin in patients with complicated urinary tract infection and/or pyelonephritis. RESULTS: A 5-day regimen with finafloxacin 800 mg q.d. (FINA05) had similar results as a 10-day regimen with finafloxacin 800 mg q.d. (FINA10). Combined microbiological and clinical responses at test of cure visit (TOC) were 70% for FINA05, 68% for FINA10, and 57% for a 10-day ciprofloxacin regimen (CIPRO10) in 193 (64 for FINA05, 68 for FINA10 and 61 for CIPRO10) patients of the microbiological intent-to-treat (mITT) population...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29338978/non-risk-adapted-surveillance-for-stage-i-testicular-cancer-critical-review-and-summary
#15
REVIEW
Phillip Martin Pierorazio, Peter Albers, Peter C Black, Torgrim Tandstad, Axel Heidenreich, Nicola Nicolai, Craig Nichols
CONTEXT: Cancer-specific survival for men with clinical stage I testicular cancer (CSITC) is uniformly excellent. Non-risk-adapted active surveillance (NRAS) is a management strategy for CSITC to minimize overtreatment and avoid possible long-term side effects of adjuvant therapy. OBJECTIVE: To review the evidence regarding oncologic outcomes for men with CSITC undergoing NRAS and discuss ongoing controversies in the management of CSITC. EVIDENCE ACQUISITION: MEDLINE/PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched from January 1, 1987 through January 1, 2017...
January 12, 2018: European Urology
https://www.readbyqxmd.com/read/29338724/development-and-validation-of-hptlc-fingerprints-of-three-species-of-alpinia-with-biomarker-galangin
#16
Anuradha S Upadhye, Anagha Rajopadhye, Lourelle Dias
BACKGROUND: Alpinia galanga (L.) Willd. commonly called as Rasna, Greater galangal or Kulinjan is a medicinally important rhizome used in Indian traditional system of medicine to cure a number of ailments. A. galanga is the main source of a galangin -a medicinally important flavanol which has a number of pharmacological properties viz. anti-mutagenic, and anti-inflammatory. Due to the high demand for the rhizome of A. galanga traders are now substituting it with rhizomes of A. calcarata and A...
January 16, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29338693/in-vitro-antimicrobial-susceptibility-testing-of-human-brucella-melitensis-isolates-from-ulanqab-of-inner-mongolia-china
#17
Zhi-Guo Liu, Dong-Dong Di, Miao Wang, Ri-Hong Liu, Hong-Yan Zhao, Dong-Ri Piao, Zhong-Zhi Zhao, Yong-Qing Hao, Ya-Nan Du, Hai Jiang, Bu-Yun Cui, Xian-Zhu Xia
BACKGROUND: Brucellosis is an endemic disease in the Inner Mongolia Autonomous Region of China and Ulanqab exhibits the highest prevalence of brucellosis in this region. Due to the complex nature of Brucellosis, a cure for this disease has proven to be elusive. Furthermore, the reduced susceptibility of Brucella spp. to antimicrobial agents has been reported as a potential cause of therapeutic failure. However, detailed in vitro antimicrobial susceptibility patterns pertaining to Brucella isolates from this region have not yet been published...
January 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29338608/immunotherapy-of-cancer-targeting-cancer-during-active-disease-or-during-dormancy
#18
Syed Ammer Shah, Melika Zarei, Saeed H Manjili, Georgi Guruli, Xiang-Yang Wang, Masoud H Manjili
Immunotherapeutic targeting of advanced stage cancers has prolonged the survival of cancer patients, yet its curative efficacy is limited due to tumor immunoediting and escape. On the other hand, human vaccines have been able to eradicate smallpox and control several other infectious diseases. The success has resulted from the administration of vaccines in prophylactic settings, or during latency periods in order to protect an individual during future exposure to the disease rather than curing an established disease...
September 2017: Immunotherapy
https://www.readbyqxmd.com/read/29338566/constructing-heparin-modified-pancreatic-decellularized-scaffold-to-improve-its-re-endothelialization
#19
Liancheng Xu, Yibing Guo, Yan Huang, Yicheng Xiong, Yang Xu, Xiaohong Li, Jingjing Lu, Lei Wang, Yao Wang, Yuhua Lu, Zhiwei Wang
Pancreas transplantation is considered as a promising therapeutic option with the potential to cure diabetes. However, efficacy of current clinical transplantation is limited by the donor organ. With regard to creating a functional pancreas-tissue equivalent for transplantation, vascularization remains a large obstacle. To enhance the angiogenic properties of pancreatic decellularized scaffold, surface modification of the vasculature was used to promote endothelialization efficiency. In this study, an endothelialized pancreatic decellularized scaffold was obtained through heparin modification under mild conditions...
January 1, 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29337897/long-term-mechanical-behavior-of-nano-silica-sol-grouting
#20
Dongjiang Pan, Nong Zhang, Chenghao Zhang, Deyu Qian, Changliang Han, Sen Yang
The longevity of grouting has a significant effect on the safe and sustainable operation of many engineering projects. A 500-day experiment was carried out to study the long-term mechanical behavior of nano silica sol grouting. The nano silica sol was activated with different proportions of a NaCl catalyst and cured under fluctuating temperature and humidity conditions. The mechanical parameters of the grout samples were tested using an electrohydraulic uniaxial compression tester and an improved Vicat instrument...
January 16, 2018: Nanomaterials
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