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https://www.readbyqxmd.com/read/29307089/genetic-and-biological-characterization-of-three-poultry-origin-h5n6-avian-influenza-viruses-with-all-internal-genes-from-genotype-s-h9n2-viruses
#1
Kaituo Liu, Min Gu, Shunlin Hu, Ruyi Gao, Juan Li, Liwei Shi, Wenqi Sun, Dong Liu, Zhao Gao, Xiulong Xu, Jiao Hu, Xiaoquan Wang, Xiaowen Liu, Sujuan Chen, Daxin Peng, Xinan Jiao, Xiufan Liu
During surveillance for avian influenza viruses, three H5N6 viruses were isolated in chickens obtained from live bird markets in eastern China, between January 2015 and April 2016. Sequence analysis revealed a high genomic homology between these poultry isolates and recent human H5N6 variants whose internal genes were derived from genotype S H9N2 avian influenza viruses. Glycan binding assays revealed that all avian H5N6 viruses were capable of binding to both human-type SAα-2,6Gal receptors and avian-type SAα-2,3Gal receptors...
January 6, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29299528/human-clade-2-3-4-4-a-h5n6-influenza-virus-lacks-mammalian-adaptation-markers-and-does-not-transmit-via-the-airborne-route-between-ferrets
#2
Sander Herfst, Chris K P Mok, Judith M A van den Brand, Stefan van der Vliet, Miruna E Rosu, Monique I Spronken, Zifeng Yang, Dennis de Meulder, Pascal Lexmond, Theo M Bestebroer, J S Malik Peiris, Ron A M Fouchier, Mathilde Richard
Since their emergence in 1997, A/H5N1 influenza viruses of the A/goose/Guangdong/1/96 lineage have diversified in multiple genetic and antigenic clades upon continued circulation in poultry in several countries in Eurasia and Africa. Since 2009, reassortant viruses carrying clade 2.3.4.4 hemagglutinin (HA) and internal and neuraminidase (NA) genes of influenza A viruses of different avian origin have been detected, yielding various HA-NA combinations, such as A/H5N1, A/H5N2, A/H5N3, A/H5N5, A/H5N6, and A/H5N8...
January 2018: MSphere
https://www.readbyqxmd.com/read/29248796/multiple-introductions-of-reassorted-highly-pathogenic-avian-influenza-viruses-h5n8-clade-2-3-4-4b-causing-outbreaks-in-wild-birds-and-poultry-in-egypt
#3
Nahed Yehia, Mahmoud M Naguib, Ruiyun Li, Naglaa Hagag, Mohamed El-Husseiny, Zainab Mosaad, Ahmed Nour, Neveen Rabea, Wafaa M Hasan, Mohamed K Hassan, Timm Harder, Abdel-Satar A Arafa
Recently, an increased incidence of outbreaks of highly pathogenic avian influenza (HPAI) H5N8 in poultry linked to infected migratory birds has been reported from different European, Asian and African countries. In Egypt, incursion of HPAI H5N8 virus of clade 2.3.4.4b has been recently registered. Full genomic characterization of 3 virus isolates from wild birds and poultry (backyard and commercial farm sectors) showed high nucleotide similarity among the HA, NA, M, and NS gene segments of the three Egyptian HPAI H5N8 viruses, indicating that they are descendants of a common ancestral virus...
December 14, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29236360/low-risk-of-avian-influenza-a-h5n6-transmission-to-depopulation-workers-in-korea
#4
Sukhyun Ryu, Jun-Sik Lim, Benjamin J Cowling, Byung Chul Chun
An outbreak of highly pathogenic avian influenza A (H5N6) virus occurred between November 20, 2016 and March 1, 2017 in poultry farms, in the Gyeonggi Province, Republic of Korea. To identify the risk of transmission of H5N6 to depopulation workers, active and passive surveillance was conducted. Virological testing of respiratory swabs with real-time reverse transcription-polymerase chain reaction was performed for workers who reported respiratory symptoms. Among 4633 depopulation workers, 25 reported respiratory symptoms, but all tested negative for H5N6...
December 13, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29220671/structural-comparison-among-the-2013-2017-avian-influenza-a-h5n6-hemagglutinin-proteins-a-computational-study-with-epidemiological-implications
#5
Marni E Cueno, Izuho Suzuki, Shiori Shimotomai, Takuma Yokoyama, Kai Nagahisa, Kenichi Imai
Avian influenza viruses easily spread allowing viral re-assortment to simply occur which in-turn increases the potential for a pandemic. A novel 2013 H5N6 influenza strain was detected among the avian population and was reported to continuously evolve, however, this was never structurally demonstrated. Here, we elucidated the putative structural evolution of the novel H5N6 influenza strain. Throughout this study, we analyzed 2013-2017 H5N6 HA protein models. Model quality was first verified before further analyses and structural comparison was made using superimposition...
November 28, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29204739/serological-evidence-of-h5-subtype-influenza-a-virus-infection-in-indigenous-avian-and-mammalian-species-in-korea
#6
Hye Kwon Kim, Hee-Jong Kim, Ji Yeong Noh, Le Van Phan, Ji Hyung Kim, Daesub Song, Woonsung Na, Aram Kang, Thi Lan Nguyen, Jeong-Hwa Shin, Dae Gwin Jeong, Sun-Woo Yoon
In Korea, H5-subtype highly pathogenic avian influenza (HPAI) has caused huge economic losses in poultry farms through outbreaks of H5N1 since 2003, H5N8 since 2013 and H5N6 since 2016. Although it was reported that long-distance migratory birds may play a major role in the global spread of avian influenza viruses (AIVs), transmission from such birds to poultry has not been confirmed. Intermediate hosts in the wild also may be a potential factor in viral transmission. Therefore, a total of 367 serum samples from wild animals were collected near major migratory bird habitats from 2011 to 2016 and tested by AIV-specific blocking ELISA and hemagglutination inhibition (HI) test...
December 4, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29176564/avian-influenza-h5n6-viruses-exhibit-differing-pathogenicities-and-transmissibilities-in-mammals
#7
Zongzheng Zhao, Zhendong Guo, Chunmao Zhang, Lina Liu, Ligong Chen, Cheng Zhang, Zhongyi Wang, Yingying Fu, Jianming Li, Huabin Shao, Qingping Luo, Jun Qian, Linna Liu
Since 2013, highly pathogenic avian influenza H5N6 viruses have emerged in poultry and caused sporadic infections in humans, increasing global concerns regarding their potential as human pandemic threats. Here, we characterized the receptor-binding specificities, pathogenicities and transmissibilities of three H5N6 viruses isolated from poultry in China. The surface genes hemagglutinin (HA) and neuraminidase (NA) were closely related to the human-originating strain A/Changsha/1/2014 (H5N6). Phylogenetic analyses showed that the HA genes were clustered in the 2...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29173583/pathogenicity-and-transmissibility-of-a-highly-pathogenic-avian-influenza-virus-h5n6-isolated-from-a-domestic-goose-in-southern-china
#8
Bin Xiang, Jianpeng Liang, Renrong You, Lujie Han, Kun Mei, Libin Chen, Ruojing Chen, Yifan Zhang, Xu Dai, Pei Gao, Ming Liao, Chencheng Xiao, Tao Ren
Since the first outbreak of H5N6 reported in Laos at 2013, there has been a dramatic increase in H5N6 strains isolated from waterfowl in China, particularly Southern China. However, pathogenicity and transmissibility of the virus in different birds remain largely unknown. In this study, a novel H5N6 virus, termed QY01, that belonged to group C in 2.3.4.4 was isolated from an apparently healthy domestic goose in Guangdong province, southern China in 2016. In order to simulate the natural transmission of different kinds of birds, we evaluated its pathogenicity and transmissibility in chickens, domestic geese and pigeons...
December 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29101372/reactivity-and-sensitivity-of-commercially-available-influenza-rapid-diagnostic-tests-in-japan
#9
Yuko Sakai-Tagawa, Seiya Yamayoshi, Chiharu Kawakami, Mai Q Le, Yuko Uchida, Takehiko Saito, Chairul A Nidom, Ira Humaira, Kathy Toohey-Kurth, Abdel-Satar Arafa, Ming-Tsan Liu, Yuelong Shu, Yoshihiro Kawaoka
Seasonal influenza virus routinely causes epidemic infections throughout the world. Sporadic infections by H5N1, H5N6, and H7N9 viruses are also reported. To treat patients suffering from such viral infections, broadly reactive and highly sensitive influenza rapid diagnostic tests (IRDTs) are required. Here, we examined the reactivity and sensitivity of 25 IRDTs available in Japan for the detection of seasonal H1N1pdm09, H3N2, and type B viruses, as well as highly pathogenic H5 and H7 viruses. All of the IRDTs tested detected the seasonal viruses and H5 and H7 viruses albeit with different sensitivities...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29075244/internal-gene-cassette-from-a-genotype-s-h9n2-avian-influenza-virus-attenuates-the-pathogenicity-of-h5-viruses-in-chickens-and-mice
#10
Xiaoli Hao, Jiongjiong Wang, Jiao Hu, Xiaolong Lu, Zhao Gao, Dong Liu, Juan Li, Xiaoquan Wang, Min Gu, Zenglei Hu, Xiaowen Liu, Shunlin Hu, Xiulong Xu, Daxin Peng, Xinan Jiao, Xiufan Liu
H9N2 avian influenza virus (AIV) of genotype S frequently donate internal genes to facilitate the generation of novel reassortants such as H7N9, H10N8, H5N2 and H5N6 AIVs, posing an enormous threat to both human health and poultry industry. However, the pathogenicity and transmission of reassortant H5 viruses with internal gene cassette of genotype S H9N2-origin in chickens and mice remain unknown. In this study, four H5 reassortants carrying the HA and NA genes from different clades of H5 viruses and the remaining internal genes from an H9N2 virus of the predominant genotype S were generated by reverse genetics...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29034617/isolation-and-characterization-of-avian-influenza-viruses-from-raw-poultry-products-illegally-imported-to-japan-by-international-flight-passengers
#11
A Shibata, T Hiono, H Fukuhara, R Sumiyoshi, A Ohkawara, K Matsuno, M Okamatsu, H Osaka, Y Sakoda
The transportation of poultry and related products for international trade contributes to transboundary pathogen spread and disease outbreaks worldwide. To prevent pathogen incursion through poultry products, many countries have regulations about animal health and poultry product quarantine. However, in Japan, animal products have been illegally introduced into the country in baggage and confiscated at the airport. Lately, the number of illegally imported poultry and the incursion risk of transboundary pathogens through poultry products have been increasing...
October 16, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29024492/experimental-infection-of-clade-1-1-2-h5n1-clade-2-3-2-1c-h5n1-and-clade-2-3-4-4-h5n6-highly-pathogenic-avian-influenza-viruses-in-dogs
#12
K S Lyoo, W Na, L V Phan, S W Yoon, M Yeom, D Song, D G Jeong
Since the emergence of highly pathogenic avian influenza (HPAI) H5N1 in Asia, the haemagglutinin (HA) gene of this virus lineage has continued to evolve in avian populations, and H5N1 lineage viruses now circulate concurrently worldwide. Dogs may act as an intermediate host, increasing the potential for zoonotic transmission of influenza viruses. Virus transmission and pathologic changes in HPAI clade 1.1.2 (H5N1)-, 2.3.2.1c (H5N1)- and 2.3.4.4 (H5N6)-infected dogs were investigated. Mild respiratory signs and antibody response were shown in dogs intranasally infected with the viruses...
October 11, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29016219/emerging-zoonotic-influenza-a-virus-detection-in-myanmar-surveillance-practices-and-findings
#13
Ye Tun Win, Emma Gardner, David Hadrill, Cho Cho Su Mon, Maung Maung Kyin, Min Thein Maw, Filip Claes, Sophie von Dobschuetz, Wantanee Kalpravidh, Kachen Wongsathapornchai, Hla Hla Mon, Win Win Myint, Wai Zin Thein, Pont Pont Mon
We describe 2-season, risk-based, virological surveillance for zoonotic avian influenza in Myanmar and report the first detection of influenza A subtypes H5N6 and H9N2 in Myanmar. The study focused mainly on the live bird markets in border townships, where illegal poultry importation from China usually takes place. The objective was to enhance early warning for low pathogenic avian influenza A(H7N9) incursion. The study followed the guidelines of the Food and Agriculture Organization (FAO) of the United Nations for influenza A(H7N9) surveillance in uninfected countries...
September 2017: Health Security
https://www.readbyqxmd.com/read/28966609/amino-acid-substitutions-associated-with-avian-h5n6-influenza-a-virus-adaptation-to-mice
#14
Chunmao Zhang, Zongzheng Zhao, Zhendong Guo, Jiajie Zhang, Jiaming Li, Yifei Yang, Shaoxia Lu, Zhongyi Wang, Min Zhi, Yingying Fu, Xiaoyu Yang, Lina Liu, Yi Zhang, Yuping Hua, Linna Liu, Hongliang Chai, Jun Qian
At least 15 cases of human beings infected with H5N6 have been reported since 2014, of which at least nine were fatal. The highly pathogenic avian H5N6 influenza virus may pose a serious threat to both public health and the poultry industry. However, the molecular features promoting the adaptation of avian H5N6 influenza viruses to mammalian hosts is not well understood. Here, we sequentially passaged an avian H5N6 influenza A virus (A/Northern Shoveler/Ningxia/488-53/2015) 10 times in mice to identify the adaptive amino acid substitutions that confer enhanced virulence to H5N6 in mammals...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28947901/evaluation-of-nxtag-respiratory-pathogen-panel-and-comparison-with-xtag-respiratory-viral-panel-fast-v2-and-film-array-respiratory-panel-for-detecting-respiratory-pathogens-in-nasopharyngeal-aspirates-and-swine-avian-origin-influenza-a-subtypes-in-culture-isolates
#15
K H Chan, K K W To, P T W Li, T L Wong, R Zhang, K K H Chik, G Chan, C C Y Yip, H L Chen, I F N Hung, J F W Chan, K Y Yuen
This study evaluated a new multiplex kit, Luminex NxTAG Respiratory Pathogen Panel, for respiratory pathogens and compared it with xTAG RVP Fast v2 and FilmArray Respiratory Panel using nasopharyngeal aspirate specimens and culture isolates of different swine/avian-origin influenza A subtypes (H2N2, H5N1, H7N9, H5N6, and H9N2). NxTAG RPP gave sensitivity of 95.2%, specificity of 99.6%, PPV of 93.5%, and NPV of 99.7%. NxTAG RPP, xTAG RVP, and FilmArray RP had highly concordant performance among each other for the detection of respiratory pathogens...
2017: Advances in Virology
https://www.readbyqxmd.com/read/28915920/current-situation-of-h9n2-subtype-avian-influenza-in-china
#16
REVIEW
Min Gu, Lijun Xu, Xiaoquan Wang, Xiufan Liu
In China, H9N2 subtype avian influenza outbreak is firstly reported in Guangdong province in 1992. Subsequently, the disease spreads into vast majority regions nationwide and has currently become endemic there. Over vicennial genetic evolution, the viral pathogenicity and transmissibility have showed an increasing trend as year goes by, posing serious threat to poultry industry. In addition, H9N2 has demonstrated significance to public health as it could not only directly infect mankind, but also donate partial or even whole cassette of internal genes to generate novel human-lethal reassortants like H5N1, H7N9, H10N8 and H5N6 viruses...
September 15, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28892736/five-distinct-reassortants-of-h5n6-highly-pathogenic-avian-influenza-a-viruses-affected-japan-during-the-winter-of-2016-2017
#17
Nobuhiro Takemae, Ryota Tsunekuni, Kirill Sharshov, Taichiro Tanikawa, Yuko Uchida, Hiroshi Ito, Kosuke Soda, Tatsufumi Usui, Ivan Sobolev, Alexander Shestopalov, Tsuyoshi Yamaguchi, Junki Mine, Toshihiro Ito, Takehiko Saito
To elucidate the evolutionary pathway, we sequenced the entire genomes of 89 H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during winter 2016-2017 and 117 AIV/HPAIVs isolated in Japan and Russia. Phylogenetic analysis showed that at least 5 distinct genotypes of H5N6 HPAIVs affected poultry and wild birds during that period. Japanese H5N6 isolates shared a common genetic ancestor in 6 of 8 genomic segments, and the PA and NS genes demonstrated 4 and 2 genetic origins, respectively...
December 2017: Virology
https://www.readbyqxmd.com/read/28888649/identification-of-two-novel-avian-influenza-a-h5n6-viruses-in-wild-birds-shanghai-in-2016
#18
Guimei He, Lichen Zhou, Caihui Zhu, Hongliang Shi, Xiaofang Li, Di Wu, Jing Liu, Jiamin Lv, Chuanxia Hu, Zhihui Li, Zhenghuan Wang, Tianhou Wang
The H5N6 avian influenza virus (AIV) has been continuously reported in wild birds, which may contribute to further geographical spread during their long-distance migrations. Active AIV surveillance in wild birds was conducted during October and November 2016 in Shanghai, China. Two novel influenza A (H5N6) viruses were detected in samples from migratory waterfowl that are genetically similar to recent South Korea and Japan H5N6 viruses collected in 2016 and 2017, highlighting the role of migratory waterfowl in the dissemination of H5N6 viruses along migratory flyways...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28859267/evolution-global-spread-and-pathogenicity-of-highly-pathogenic-avian-influenza-h5nx-clade-2-3-4-4
#19
REVIEW
Dong-Hun Lee, Kateri Bertran, Jung-Hoon Kwon, David E Swayne
Novel subtypes of Asian-origin (Goose/Guangdong lineage) H5 highly pathogenic avian influenza (HPAI) viruses belonging to clade 2.3.4, such as H5N2, H5N5, H5N6, and H5N8, have been identified in China since 2008 and have since evolved into four genetically distinct clade 2.3.4.4 groups (A-D). Since 2014, HPAI clade 2.3.4.4 viruses have spread rapidly via migratory wild aquatic birds and have evolved through reassortment with prevailing local low pathogenicity avian influenza viruses. Group A H5N8 viruses and its reassortant viruses caused outbreaks in wide geographic regions (Asia, Europe, and North America) during 2014-2015...
August 31, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28815716/characterization-of-h5n6-highly-pathogenic-avian-influenza-viruses-isolated-from-wild-and-captive-birds-in-the-winter-season-of-2016-2017-in-northern-japan
#20
Takahiro Hiono, Masatoshi Okamatsu, Keita Matsuno, Atsushi Haga, Ritsuko Iwata, Lam Thanh Nguyen, Mizuho Suzuki, Yuto Kikutani, Hiroshi Kida, Manabu Onuma, Yoshihiro Sakoda
On November 15, 2016, a suspected case of highly pathogenic avian influenza (HPAI) in a dead black swan was reported from a zoo in Akita prefecture, northern Japan, and an HPAI virus (HPAIV) belonging to the H5N6 subtype was isolated from specimens taken from the bird. After the initial report, 230 cases of HPAI caused by H5N6 viruses were reported from wild birds, captive birds, and domestic poultry farms throughout the country during the winter season. In the present study, we further characterized 66 H5N6 HPAIVs isolated from northern Japan...
August 16, 2017: Microbiology and Immunology
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