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https://www.readbyqxmd.com/read/29101372/reactivity-and-sensitivity-of-commercially-available-influenza-rapid-diagnostic-tests-in-japan
#1
Yuko Sakai-Tagawa, Seiya Yamayoshi, Chiharu Kawakami, Mai Q Le, Yuko Uchida, Takehiko Saito, Chairul A Nidom, Ira Humaira, Kathy Toohey-Kurth, Abdel-Satar Arafa, Ming-Tsan Liu, Yuelong Shu, Yoshihiro Kawaoka
Seasonal influenza virus routinely causes epidemic infections throughout the world. Sporadic infections by H5N1, H5N6, and H7N9 viruses are also reported. To treat patients suffering from such viral infections, broadly reactive and highly sensitive influenza rapid diagnostic tests (IRDTs) are required. Here, we examined the reactivity and sensitivity of 25 IRDTs available in Japan for the detection of seasonal H1N1pdm09, H3N2, and type B viruses, as well as highly pathogenic H5 and H7 viruses. All of the IRDTs tested detected the seasonal viruses and H5 and H7 viruses albeit with different sensitivities...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29075244/internal-gene-cassette-from-a-genotype-s-h9n2-avian-influenza-virus-attenuates-the-pathogenicity-of-h5-viruses-in-chickens-and-mice
#2
Xiaoli Hao, Jiongjiong Wang, Jiao Hu, Xiaolong Lu, Zhao Gao, Dong Liu, Juan Li, Xiaoquan Wang, Min Gu, Zenglei Hu, Xiaowen Liu, Shunlin Hu, Xiulong Xu, Daxin Peng, Xinan Jiao, Xiufan Liu
H9N2 avian influenza virus (AIV) of genotype S frequently donate internal genes to facilitate the generation of novel reassortants such as H7N9, H10N8, H5N2 and H5N6 AIVs, posing an enormous threat to both human health and poultry industry. However, the pathogenicity and transmission of reassortant H5 viruses with internal gene cassette of genotype S H9N2-origin in chickens and mice remain unknown. In this study, four H5 reassortants carrying the HA and NA genes from different clades of H5 viruses and the remaining internal genes from an H9N2 virus of the predominant genotype S were generated by reverse genetics...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29034617/isolation-and-characterization-of-avian-influenza-viruses-from-raw-poultry-products-illegally-imported-to-japan-by-international-flight-passengers
#3
A Shibata, T Hiono, H Fukuhara, R Sumiyoshi, A Ohkawara, K Matsuno, M Okamatsu, H Osaka, Y Sakoda
The transportation of poultry and related products for international trade contributes to transboundary pathogen spread and disease outbreaks worldwide. To prevent pathogen incursion through poultry products, many countries have regulations about animal health and poultry product quarantine. However, in Japan, animal products have been illegally introduced into the country in baggage and confiscated at the airport. Lately, the number of illegally imported poultry and the incursion risk of transboundary pathogens through poultry products have been increasing...
October 16, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29024492/experimental-infection-of-clade-1-1-2-h5n1-clade-2-3-2-1c-h5n1-and-clade-2-3-4-4-h5n6-highly-pathogenic-avian-influenza-viruses-in-dogs
#4
K S Lyoo, W Na, L V Phan, S W Yoon, M Yeom, D Song, D G Jeong
Since the emergence of highly pathogenic avian influenza (HPAI) H5N1 in Asia, the haemagglutinin (HA) gene of this virus lineage has continued to evolve in avian populations, and H5N1 lineage viruses now circulate concurrently worldwide. Dogs may act as an intermediate host, increasing the potential for zoonotic transmission of influenza viruses. Virus transmission and pathologic changes in HPAI clade 1.1.2 (H5N1)-, 2.3.2.1c (H5N1)- and 2.3.4.4 (H5N6)-infected dogs were investigated. Mild respiratory signs and antibody response were shown in dogs intranasally infected with the viruses...
October 11, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29016219/emerging-zoonotic-influenza-a-virus-detection-in-myanmar-surveillance-practices-and-findings
#5
Ye Tun Win, Emma Gardner, David Hadrill, Cho Cho Su Mon, Maung Maung Kyin, Min Thein Maw, Filip Claes, Sophie von Dobschuetz, Wantanee Kalpravidh, Kachen Wongsathapornchai, Hla Hla Mon, Win Win Myint, Wai Zin Thein, Pont Pont Mon
We describe 2-season, risk-based, virological surveillance for zoonotic avian influenza in Myanmar and report the first detection of influenza A subtypes H5N6 and H9N2 in Myanmar. The study focused mainly on the live bird markets in border townships, where illegal poultry importation from China usually takes place. The objective was to enhance early warning for low pathogenic avian influenza A(H7N9) incursion. The study followed the guidelines of the Food and Agriculture Organization (FAO) of the United Nations for influenza A(H7N9) surveillance in uninfected countries...
September 2017: Health Security
https://www.readbyqxmd.com/read/28966609/amino-acid-substitutions-associated-with-avian-h5n6-influenza-a-virus-adaptation-to-mice
#6
Chunmao Zhang, Zongzheng Zhao, Zhendong Guo, Jiajie Zhang, Jiaming Li, Yifei Yang, Shaoxia Lu, Zhongyi Wang, Min Zhi, Yingying Fu, Xiaoyu Yang, Lina Liu, Yi Zhang, Yuping Hua, Linna Liu, Hongliang Chai, Jun Qian
At least 15 cases of human beings infected with H5N6 have been reported since 2014, of which at least nine were fatal. The highly pathogenic avian H5N6 influenza virus may pose a serious threat to both public health and the poultry industry. However, the molecular features promoting the adaptation of avian H5N6 influenza viruses to mammalian hosts is not well understood. Here, we sequentially passaged an avian H5N6 influenza A virus (A/Northern Shoveler/Ningxia/488-53/2015) 10 times in mice to identify the adaptive amino acid substitutions that confer enhanced virulence to H5N6 in mammals...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28947901/evaluation-of-nxtag-respiratory-pathogen-panel-and-comparison-with-xtag-respiratory-viral-panel-fast-v2-and-film-array-respiratory-panel-for-detecting-respiratory-pathogens-in-nasopharyngeal-aspirates-and-swine-avian-origin-influenza-a-subtypes-in-culture-isolates
#7
K H Chan, K K W To, P T W Li, T L Wong, R Zhang, K K H Chik, G Chan, C C Y Yip, H L Chen, I F N Hung, J F W Chan, K Y Yuen
This study evaluated a new multiplex kit, Luminex NxTAG Respiratory Pathogen Panel, for respiratory pathogens and compared it with xTAG RVP Fast v2 and FilmArray Respiratory Panel using nasopharyngeal aspirate specimens and culture isolates of different swine/avian-origin influenza A subtypes (H2N2, H5N1, H7N9, H5N6, and H9N2). NxTAG RPP gave sensitivity of 95.2%, specificity of 99.6%, PPV of 93.5%, and NPV of 99.7%. NxTAG RPP, xTAG RVP, and FilmArray RP had highly concordant performance among each other for the detection of respiratory pathogens...
2017: Advances in Virology
https://www.readbyqxmd.com/read/28915920/current-situation-of-h9n2-subtype-avian-influenza-in-china
#8
REVIEW
Min Gu, Lijun Xu, Xiaoquan Wang, Xiufan Liu
In China, H9N2 subtype avian influenza outbreak is firstly reported in Guangdong province in 1992. Subsequently, the disease spreads into vast majority regions nationwide and has currently become endemic there. Over vicennial genetic evolution, the viral pathogenicity and transmissibility have showed an increasing trend as year goes by, posing serious threat to poultry industry. In addition, H9N2 has demonstrated significance to public health as it could not only directly infect mankind, but also donate partial or even whole cassette of internal genes to generate novel human-lethal reassortants like H5N1, H7N9, H10N8 and H5N6 viruses...
September 15, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28892736/five-distinct-reassortants-of-h5n6-highly-pathogenic-avian-influenza-a-viruses-affected-japan-during-the-winter-of-2016-2017
#9
Nobuhiro Takemae, Ryota Tsunekuni, Kirill Sharshov, Taichiro Tanikawa, Yuko Uchida, Hiroshi Ito, Kosuke Soda, Tatsufumi Usui, Ivan Sobolev, Alexander Shestopalov, Tsuyoshi Yamaguchi, Junki Mine, Toshihiro Ito, Takehiko Saito
To elucidate the evolutionary pathway, we sequenced the entire genomes of 89 H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during winter 2016-2017 and 117 AIV/HPAIVs isolated in Japan and Russia. Phylogenetic analysis showed that at least 5 distinct genotypes of H5N6 HPAIVs affected poultry and wild birds during that period. Japanese H5N6 isolates shared a common genetic ancestor in 6 of 8 genomic segments, and the PA and NS genes demonstrated 4 and 2 genetic origins, respectively...
December 2017: Virology
https://www.readbyqxmd.com/read/28888649/identification-of-two-novel-avian-influenza-a-h5n6-viruses-in-wild-birds-shanghai-in-2016
#10
Guimei He, Lichen Zhou, Caihui Zhu, Hongliang Shi, Xiaofang Li, Di Wu, Jing Liu, Jiamin Lv, Chuanxia Hu, Zhihui Li, Zhenghuan Wang, Tianhou Wang
The H5N6 avian influenza virus (AIV) has been continuously reported in wild birds, which may contribute to further geographical spread during their long-distance migrations. Active AIV surveillance in wild birds was conducted during October and November 2016 in Shanghai, China. Two novel influenza A (H5N6) viruses were detected in samples from migratory waterfowl that are genetically similar to recent South Korea and Japan H5N6 viruses collected in 2016 and 2017, highlighting the role of migratory waterfowl in the dissemination of H5N6 viruses along migratory flyways...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28859267/evolution-global-spread-and-pathogenicity-of-highly-pathogenic-avian-influenza-h5nx-clade-2-3-4-4
#11
REVIEW
Dong-Hun Lee, Kateri Bertran, Jung-Hoon Kwon, David E Swayne
Novel subtypes of Asian-origin (Goose/Guangdong lineage) H5 highly pathogenic avian influenza (HPAI) viruses belonging to clade 2.3.4, such as H5N2, H5N5, H5N6, and H5N8, have been identified in China since 2008 and have since evolved into four genetically distinct clade 2.3.4.4 groups (A-D). Since 2014, HPAI clade 2.3.4.4 viruses have spread rapidly via migratory wild aquatic birds and have evolved through reassortment with prevailing local low pathogenicity avian influenza viruses. Group A H5N8 viruses and its reassortant viruses caused outbreaks in wide geographic regions (Asia, Europe, and North America) during 2014-2015...
August 31, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28815716/characterization-of-h5n6-highly-pathogenic-avian-influenza-viruses-isolated-from-wild-and-captive-birds-in-the-winter-season-of-2016-2017-in-northern-japan
#12
Takahiro Hiono, Masatoshi Okamatsu, Keita Matsuno, Atsushi Haga, Ritsuko Iwata, Lam Thanh Nguyen, Mizuho Suzuki, Yuto Kikutani, Hiroshi Kida, Manabu Onuma, Yoshihiro Sakoda
On November 15, 2016, a suspected case of highly pathogenic avian influenza (HPAI) in a dead black swan was reported from a zoo in Akita prefecture, northern Japan, and an HPAI virus (HPAIV) belonging to the H5N6 subtype was isolated from specimens taken from the bird. After the initial report, 230 cases of HPAI caused by H5N6 viruses were reported from wild birds, captive birds, and domestic poultry farms throughout the country during the winter season. In the present study, we further characterized 66 H5N6 HPAIVs isolated from northern Japan...
August 16, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28736803/genetic-and-pathogenic-analysis-of-a-novel-reassortant-h5n6-influenza-virus-isolated-from-waterfowl-in-south-korea-in-2016
#13
In Hong Lee, Seo Yeon Jin, Sang Heui Seo
A novel reassortant highly pathogenic H5N6 influenza virus was isolated from waterfowl in South Korea in 2016. Seven genes of this virus originated from an H5N6 virus from China, whereas the remaining gene, PB1, was from an unknown virus. This virus productively infected pigs, which showed viral shedding through their noses and developed severe interstitial pneumonia.
November 2017: Archives of Virology
https://www.readbyqxmd.com/read/28730524/genetic-characterization-of-novel-reassortant-h5n6-subtype-influenza-viruses-isolated-from-cats-in-eastern-china
#14
Xueliang Cao, Fan Yang, Haibo Wu, Lihua Xu
Cats are susceptible to influenza A viruses and therefore may act as transmission vectors within households, posing a potential public health concern. Two novel reassortant H5N6 influenza viruses were isolated from cats in Zhejiang Province, Eastern China, in 2016. Both viruses were characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis showed that these viruses received their genes from H5N6, H9N2, and H7N9 influenza viruses isolated from China...
November 2017: Archives of Virology
https://www.readbyqxmd.com/read/28677861/a-clinical-approach-to-the-threat-of-emerging-influenza-viruses-in-the-asia-pacific-region
#15
REVIEW
David S C Hui, Nelson Lee, Paul K S Chan
Seasonal influenza epidemics and periodic pandemics are important causes of morbidity and mortality. Patients with chronic co-morbid illness, those at the extremes of age and pregnant women are at higher risks of complications requiring hospitalization, whereas young adults and obese individuals were also at increased risk during the A(H1N1) pandemic in 2009. Avian influenza A(H5N1) and A(H7N9) viruses have continued to circulate widely in some poultry populations and infect humans sporadically since 1997 and 2013, respectively...
July 5, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28676793/immune-responses-of-chickens-infected-with-wild-bird-origin-h5n6-avian-influenza-virus
#16
Shimin Gao, Yinfeng Kang, Runyu Yuan, Haili Ma, Bin Xiang, Zhaoxiong Wang, Xu Dai, Fumin Wang, Jiajie Xiao, Ming Liao, Tao Ren
Since April 2014, new infections of H5N6 avian influenza virus (AIV) in humans and domestic poultry have caused considerable economic losses in the poultry industry and posed an enormous threat to human health worldwide. In previous research using gene sequence and phylogenetic analysis, we reported that H5N6 AIV isolated in February 2015 (ZH283) in Pallas's sandgrouse was highly similar to that isolated in a human in December 2015 (A/Guangdong/ZQ874/2015), whereas a virus (i.e., SW8) isolated in oriental magpie-robin in 2014 was highly similar to that of A/chicken/Dongguan/2690/2013 (H5N6)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28659898/biological-characterizations-of-h5nx-avian-influenza-viruses-embodying-different-neuraminidases
#17
Yuandi Yu, Zaoyue Zhang, Huanan Li, Xiuhui Wang, Bo Li, Xingxing Ren, Zhaoyong Zeng, Xu Zhang, Shukai Liu, Pingsheng Hu, Wenbao Qi, Ming Liao
The H5 subtype virus of Highly Pathogenic Avian Influenza Virus has caused huge economic losses to the poultry industry and is a threat to human health. Until 2010, H5N1 subtype virus was the major genotype in China. Since 2011, reassortant H5N2, H5N6, and H5N8 viruses were identified in domestic poultry in China. The clade 2.3.4.4 H5N6 and H5N8 AIV has now spread to most of China. Clade 2.3.4.4 H5N6 virus has caused 17 human deaths. However, the prevalence, pathogenicity, and transmissibility of the distinct NA reassortment with H5 subtypes viruses (H5Nx) is unknown...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28588293/human-infections-with-novel-reassortant-h5n6-avian-influenza-viruses-in-china
#18
Ye Zhang, Minmei Chen, Yiwei Huang, Wenfei Zhu, Lei Yang, Lidong Gao, Xiaodan Li, Fuyin Bi, Chaoyang Huang, Ning Kang, Hengjiao Zhang, Zi Li, Hong Bo, Dayan Wang, Yuelong Shu
No abstract text is available yet for this article.
June 7, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28453859/temporal-and-spatial-characteristics-of-highly-pathogenic-avian-influenza-outbreaks-in-china-during-2004-to-2015
#19
Mingyue Liu, Qian Lu, Shuxia Zhang, Xiaolong Feng, Md Shakhawat Hossain
Identifying the temporal and spatial characteristics of highly pathogenic avian influenza (HPAI) outbreaks is very important for developing effective and appropriate countermeasures against HPAI and promoting sustainable development in the poultry industry. This study aimed to analyze four aspects of the temporal and spatial characteristics of HPAI outbreaks in China, including the frequency of HPAI outbreaks, numbers of dead animals (died or culled), types of HPAI viruses, and species of infected animals. Temporal characteristics showed that the frequency of HPAI outbreaks decreased and then increased, with some years deviating from the main trend in 2004 to 2010 and 2011 to 2015, while the largest number of dead animals due to HPAI outbreaks was in 2005...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28407105/preliminary-epidemiologic-assessment-of-human-infections-with-highly-pathogenic-avian-influenza-a-h5n6-virus-china
#20
Hui Jiang, Peng Wu, Timothy M Uyeki, Jianfeng He, Zhihong Deng, Wen Xu, Qiang Lv, Jin Zhang, Yang Wu, Tim K Tsang, Min Kang, Jiandong Zheng, Lili Wang, Bingyi Yang, Ying Qin, Luzhao Feng, Vicky J Fang, George F Gao, Gabriel M Leung, Hongjie Yu, Benjamin J Cowling
Background: Since 2014, 17 human cases of infection with the newly emerged highly pathogenic avian influenza A(H5N6) virus have been identified in China to date. The epidemiologic characteristics of laboratory-confirmed A(H5N6) cases were compared to A(H5N1) and A(H7N9) cases in mainland China. Methods: Data on laboratory-confirmed H5N6, H5N1, and H7N9 cases identified in mainland China were analyzed to compare epidemiologic characteristics and clinical severity...
August 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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