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https://www.readbyqxmd.com/read/28327168/identification-of-two-novel-reassortant-avian-influenza-a-h5n6-viruses-in-whooper-swans-in-korea-2016
#1
Jipseol Jeong, Chanjin Woo, Hon S Ip, Injung An, Youngsik Kim, Kwanghee Lee, Seong-Deok Jo, Kidong Son, Saemi Lee, Jae-Ku Oem, Seung-Jun Wang, Yongkwan Kim, Jeonghwa Shin, Jonathan Sleeman, Weonhwa Jheong
BACKGROUND: On November 20, 2016 two novel strains of H5N6 highly pathogenic avian influenza virus (HPAIVs) were isolated from three whooper swans (Cygnus cygnus) at Gangjin Bay in South Jeolla province, South Korea. Identification of HPAIVs in wild birds is significant as there is a potential risk of transmission of these viruses to poultry and humans. RESULTS: Phylogenetic analysis revealed that Gangjin H5N6 viruses classified into Asian H5 clade 2.3.4.4 lineage and were distinguishable from H5N8 and H5N1 HPAIVs previously isolated in Korea...
March 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/28322695/characterization-of-highly-pathogenic-avian-influenza-virus-a-h5n6-japan-november-2016
#2
Masatoshi Okamatsu, Makoto Ozawa, Kosuke Soda, Hiroki Takakuwa, Atsushi Haga, Takahiro Hiono, Aya Matsuu, Yuko Uchida, Ritsuko Iwata, Keita Matsuno, Masakazu Kuwahara, Toshiyo Yabuta, Tatsufumi Usui, Hiroshi Ito, Manabu Onuma, Yoshihiro Sakoda, Takehiko Saito, Koichi Otsuki, Toshihiro Ito, Hiroshi Kida
Highly pathogenic avian influenza viruses (HPAIVs) A(H5N6) were concurrently introduced into several distant regions of Japan in November 2016. These viruses were classified into the genetic clade 2.3.4.4c and were genetically closely related to H5N6 HPAIVs recently isolated in South Korea and China. In addition, these HPAIVs showed further antigenic drift.
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28294126/highly-pathogenic-h5n6-influenza-a-viruses-recovered-from-wild-birds-in-guangdong-southern-china-2014-2015
#3
Yinfeng Kang, Lu Liu, Minsha Feng, Runyu Yuan, Can Huang, Yangtong Tan, Pei Gao, Dan Xiang, Xiaqiong Zhao, Yanling Li, David M Irwin, Yongyi Shen, Tao Ren
Since 2013, highly pathogenic (HP) H5N6 influenza A viruses (IAVs) have emerged in poultry in Asia, especially Southeast Asia. These viruses have also caused sporadic infections in humans within the same geographic areas. Active IAV surveillance in wild birds sampled in Guangdong province, China from August 2014 through February 2015 resulted in the recovery of three H5N6 IAVs. These H5N6 IAV isolates possess the basic amino acid motif at the HA1-HA2 cleavage site that is associated with highly pathogenic IAVs infecting chickens...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28293218/genetic-characterization-of-continually-evolving-highly-pathogenic-h5n6-influenza-viruses-in-china-2012-2016
#4
Meng Li, Na Zhao, Jing Luo, Yuan Li, Lin Chen, Jiajun Ma, Lin Zhao, Guohui Yuan, Chengmin Wang, Yutian Wang, Yanhua Liu, Hongxuan He
H5N6 is a highly pathogenic avian influenza (HPAI) and a zoonotic disease that causes recurring endemics in East Asia. At least 155 H5N6 outbreaks, including 15 human infections, have been reported in China. These repeated outbreaks have increased concern that the H5N6 virus may cross over to humans and cause a pandemic. In February, 2016, peafowls in a breeding farm exhibited a highly contagious disease. Post-mortem examinations, including RT-PCR, and virus isolation, confirmed that the highly pathogenic H5N6 influenza virus was the causative agent, and the strain was named A/Pavo Cristatus/Jiangxi/JA1/2016...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28284997/multiple-novel-h5n6-highly-pathogenic-avian-influenza-viruses-south-korea-2016
#5
Eun-Kyoung Lee, Byung-Min Song, Yu-Na Lee, Gyeong-Beom Heo, You-Chan Bae, Sung-Joon Joh, Seok-Chan Park, Kang-Seuk Choi, Hyun-Jeong Lee, Il Jang, Min-Su Kang, Ok-Mi Jeong, Byung-Kook Choi, Sang-Man Lee, Suk Chan Jeong, Bong-Kyun Park, Hee-Soo Lee, Youn-Jeong Lee
We report the identification of novel highly pathogenic avian influenza viruses of subtype H5N6, clade 2.3.4.4, that presumably originated from China. In addition, reassortant strains with Eurasian lineage low pathogenic avian influenza viruses were isolated in wild birds and poultry in South Korea. The emergence of these novel H5N6 viruses and their circulation among bird populations are of great concern because of the potential for virus dissemination with intercontinental wild bird migration.
March 8, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28275173/tropism-and-innate-host-responses-of-influenza-a-h5n6-virus-an-analysis-of-ex%C3%A2-vivo-and-in-vitro-cultures-of-the-human-respiratory-tract
#6
Kenrie P Y Hui, Louisa L Y Chan, Denise I T Kuok, Chris K P Mok, Zi-Feng Yang, Run-Feng Li, Geraldine S M Luk, Elaine F Lee, Jimmy C C Lai, Hui-Ling Yen, Huachen Zhu, Yi Guan, John M Nicholls, J S Malik Peiris, Michael C W Chan
Since their first isolation in 2013, influenza A/H5N6 viruses have spread amongst poultry across multiple provinces in China and to Laos, Vietnam and Myanmar. So far, there have been 14 human H5N6 infections with 10 fatalities.We investigated the tropism, replication competence and cytokine induction of one human and two avian H5N6 isolates in ex vivo and in vitro cultures derived from the human respiratory tract. Virus tropism and replication were studied in ex vivo cultures of human nasopharynx, bronchus and lung...
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28273867/comparative-epidemiology-of-human-fatal-infections-with-novel-high-h5n6-and-h5n1-and-low-h7n9-and-h9n2-pathogenicity-avian-influenza-a-viruses
#7
Zu-Qun Wu, Yi Zhang, Na Zhao, Zhao Yu, Hao Pan, Ta-Chien Chan, Zhi-Ruo Zhang, She-Lan Liu
This study aimed to assess the mortality risks for human infection with high (HPAI) and low (LPAI) pathogenicity avian influenza viruses. The HPAI case fatality rate (CFR) was far higher than the LPAI CFR [66.0% (293/444) vs. 68.75% (11/16) vs. 40.4% (265/656) vs. 0.0% (0/18) in the cases with H5N1, H5N6, H7N9, and H9N2 viruses, respectively; p < 0.001]. Similarly, the CFR of the index cases was greater than the secondary cases with H5N1 [100% (43/43) vs. 43.3% (42/97), p < 0.001]. Old age [22.5 vs. 17 years for H5N1, p = 0...
March 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28240976/reassortant-clade-2-3-4-4-avian-influenza-a-h5n6-virus-in-a-wild-mandarin-duck-south-korea-2016
#8
Jung-Hoon Kwon, Dong-Hun Lee, David E Swayne, Jin-Yong Noh, Seong-Su Yuk, Tseren-Ochir Erdene-Ochir, Woo-Tack Hong, Jei-Hyun Jeong, Sol Jeong, Gyeong-Bin Gwon, Seok Lee, Chang-Seon Song
A reassortant clade 2.3.4.4 avian influenza A(H5N6) virus was isolated from a fecal sample of a Mandarin duck (Aix galericulata) in South Korea during October 2016. This virus was genetically similar to H5N6 subtype virus isolates from China, Vietnam, Laos, and Hong Kong, including human isolates.
May 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28222327/diversity-evolution-and-population-dynamics-of-avian-influenza-viruses-circulating-in-the-live-poultry-markets-in-china
#9
Liang-Jun Chen, Xian-Dan Lin, Jun-Hua Tian, Yong Liao, Xu-Hua Ying, Jian-Wei Shao, Bin Yu, Jing-Jing Guo, Miao-Ruo Wang, Ying Peng, Mang Shi, Edward C Holmes, Zhan-Qiu Yang, Yong-Zhen Zhang
Live poultry markets (LPMs) are an important source of novel avian influenza viruses (AIV). During 2015-2016 we surveyed AIV diversity in ten LPMs in Hubei, Zhejiang and Jiangxi provinces, China. A high diversity and prevalence of AIVs (totaling 12 subtypes) was observed in LPMs in these provinces. Strikingly, however, the subtypes discovered during 2015-2016 were markedly different to those reported by us in these same localities one year previously, suggesting a dynamic shift in viral genetic diversity over the course of a single year...
February 18, 2017: Virology
https://www.readbyqxmd.com/read/28105530/molecular-characterization-of-a-novel-reassortant-h7n6-subtype-avian-influenza-virus-from-poultry-in-eastern-china-in-2016
#10
Haibo Wu, Rufeng Lu, Xiuming Peng, Xiaorong Peng, Bin Chen, Linfang Cheng, Nanping Wu
During the surveillance for avian influenza viruses (AIVs) in live poultry markets in Eastern China, in 2016, a novel reassortant H7N6 AIV was isolated from a chicken. Phylogenetic analysis showed that this strain received its genes from H9N2, H7N9 and H5N6 AIVs infecting poultry in China. This strain showed moderate pathogenicity in mice and was able to replicate in mice without prior adaptation. Considering that this novel reassorted H7N6 virus was isolated from poultry in this study, it is possible that chickens play an important role in the generation of novel reassorted H7N6 AIVs...
January 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28079520/genetic-characterisation-of-novel-highly-pathogenic-avian-influenza-hpai-h5n6-viruses-isolated-in-birds-south-korea-november-2016
#11
Young-Jae Si, In Won Lee, Eun-Ha Kim, Young-Il Kim, Hyeok-Il Kwon, Su-Jin Park, Hiep Dinh Nguyen, Se Mi Kim, Jin-Jung Kwon, Won-Suk Choi, Yun Hee Beak, Min-Suk Song, Chul-Joong Kim, Richard J Webby, Young-Ki Choi
A novel genotype of H5N6 influenza viruses was isolated from migratory birds in South Korea during November 2016. Domestic outbreaks of this virus were associated with die-offs of wild birds near reported poultry cases in Chungbuk province, central South Korea. Genetic analysis and animal studies demonstrated that the Korean H5N6 viruses are highly pathogenic avian influenza (HPAI) viruses and that these viruses are novel reassortants of at least three different subtypes (H5N6, H4N2 and H1N1).
January 5, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28057117/-molecular-analysis-of-hemagglutinin-and-neuraminidase-genes-of-avian-influenza-virus-h5n6-subtype-in-the-border-of-yunnan-province-from-2014-to-2015
#12
Q Kong, H Y Zhao, K Tian, B F Duan, Y Y Hu, T S Hu, Y G Zhang, W D Zhang, F Q Zhang
No abstract text is available yet for this article.
December 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28003485/genesis-and-dissemination-of-highly-pathogenic-h5n6-avian-influenza-viruses
#13
Lei Yang, Wenfei Zhu, Xiaodan Li, Hong Bo, Ye Zhang, Shumei Zou, Rongbao Gao, Jie Dong, Xiang Zhao, Wenbing Chen, Libo Dong, Xiaohui Zou, Yongcai Xing, Dayan Wang, Yuelong Shu
Clade 2.3.4.4 highly pathogenic avian influenza viruses (H5Nx) have spread from Asia to other parts of the world. Since 2014, human infections with clade 2.3.4.4 highly pathogenic avian influenza H5N6 viruses have been continuously reported in China. To investigate the genesis of the virus, we analyzed 123 H5 or N6 environmental viruses sampled from live-poultry markets or farms from 2012 to 2015 in Mainland China. Our results indicated that clade 2.3.4.4 H5N2/N6/N8 viruses shared the same hemagglutinin gene as originated in early 2009...
March 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28003481/shifting-clade-distribution-reassortment-and-emergence-of-new-subtypes-of-highly-pathogenic-avian-influenza-a-h5-viruses-collected-from-vietnamese-poultry-from-2012-to-2015
#14
Diep T Nguyen, Yunho Jang, Tho D Nguyen, Joyce Jones, Samuel S Shepard, Hua Yang, Nancy Gerloff, Thomas Fabrizio, Long V Nguyen, Ken Inui, Genyan Yang, Adrian Creanga, Li Wang, Duong T Mai, Sharmi Thor, James Stevens, Thanh L To, David E Wentworth, Tung Nguyen, Dong V Pham, Juliet E Bryant, C Todd Davis
Whole-genome sequences of representative highly pathogenic avian influenza A(H5) viruses from Vietnam were generated, comprising samples from poultry outbreaks and active market surveillance collected from January 2012 to August 2015. Six hemagglutinin gene clades were characterized. Clade 1.1.2 was predominant in southern Mekong provinces throughout 2012 and 2013 but gradually disappeared and was not detected after April 2014. Clade 2.3.2.1c viruses spread rapidly during 2012 and were detected in the south and center of the country...
March 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27916476/genesis-evolution-and-prevalence-of-h5n6-avian-influenza-viruses-in-china
#15
Yuhai Bi, Quanjiao Chen, Qianli Wang, Jianjun Chen, Tao Jin, Gary Wong, Chuansong Quan, Jun Liu, Jun Wu, Renfu Yin, Lihua Zhao, Mingxin Li, Zhuang Ding, Rongrong Zou, Wen Xu, Hong Li, Huijun Wang, Kegong Tian, Guanghua Fu, Yu Huang, Alexander Shestopalov, Shoujun Li, Bing Xu, Hongjie Yu, Tingrong Luo, Lin Lu, Xun Xu, Yang Luo, Yingxia Liu, Weifeng Shi, Di Liu, George Fu Gao
Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ducks. Phylogenetic analysis reveals that H5N6 arose from reassortments of H5 and H6N6 viruses, with the hemagglutinin and neuraminidase combinations being strongly lineage specific...
December 14, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27910950/human-antibody-3e1-targets-the-ha-stem-region-of-h1n1-and-h5n6-influenza-a-viruses
#16
Wenshuai Wang, Xiaoyu Sun, Yanbing Li, Jinpeng Su, Zhiyang Ling, Tianlong Zhang, Fang Wang, Hong Zhang, Hualan Chen, Jianping Ding, Bing Sun
As influenza A viruses remain a major threat to human health worldwide, the discovery of broadly neutralizing monoclonal antibodies that recognize conserved epitopes would facilitate the development of antibody-based therapeutic strategies. Here we report that a VH4-4-encoded human mAb named 3E1 could neutralize H1 and H5 subtype viruses in vitro and protect mice against the H1N1 and H5N6 viruses by inhibiting the low pH-induced conformational rearrangement of haemagglutinin (HA), hence blocking membrane fusion...
December 2, 2016: Nature Communications
https://www.readbyqxmd.com/read/27899915/novel-h7n2-and-h5n6-avian-influenza-a-viruses-in-sentinel-chickens-a-sentinel-chicken-surveillance-study
#17
Teng Zhao, Yan-Hua Qian, Shan-Hui Chen, Guo-Lin Wang, Meng-Na Wu, Yong Huang, Guang-Yuan Ma, Li-Qun Fang, Gregory C Gray, Bing Lu, Yi-Gang Tong, Mai-Juan Ma, Wu-Chun Cao
In 2014, a sentinel chicken surveillance for avian influenza viruses was conducted in aquatic bird habitat near Wuxi City, Jiangsu Province, China. Two H7N2, one H5N6, and two H9N2 viruses were isolated. Sequence analysis revealed that the H7N2 virus is a novel reassortant of H7N9 and H9N2 viruses and H5N6 virus is a reassortant of H5N1 clade 2.3.4 and H6N6 viruses. Substitutions V186 and L226 (H3 numbering) in the hemagglutinin (HA) gene protein was found in two H7N2 viruses but not in the H5N6 virus. Two A138 and A160 mutations were identified in the HA gene protein of all three viruses but a P128 mutation was only observed in the H5N6 virus...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27869615/highly-pathogenic-influenza-a-h5nx-viruses-with-altered-h5-receptor-binding-specificity
#18
Hongbo Guo, Erik de Vries, Ryan McBride, Jojanneke Dekkers, Wenjie Peng, Kim M Bouwman, Corwin Nycholat, M Helene Verheije, James C Paulson, Frank J M van Kuppeveld, Cornelis A M de Haan
Emergence and intercontinental spread of highly pathogenic avian influenza A(H5Nx) virus clade 2.3.4.4 is unprecedented. H5N8 and H5N2 viruses have caused major economic losses in the poultry industry in Europe and North America, and lethal human infections with H5N6 virus have occurred in Asia. Knowledge of the evolution of receptor-binding specificity of these viruses, which might affect host range, is urgently needed. We report that emergence of these viruses is accompanied by a change in receptor-binding specificity...
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27865960/identification-of-inonotus-obliquus-polysaccharide-with-broad-spectrum-antiviral-activity-against-multi-feline-viruses
#19
Jin Tian, Xiaoliang Hu, Dafei Liu, Hongxia Wu, Liandong Qu
Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. Using cell models of feline calicivirus (FCV), we demonstrated that IOP treatment was capable of exhibiting anti-FCV strain F9 activity in cell-based assays and also showed low cytotoxicity. Investigation of the mechanism of action of the compound revealed that IOP treatment induces its inhibitory actions directly on virus particles through blocking viral binding/absorpting...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27782815/the-complexity-of-human-infected-aiv-h5n6-isolated-from-china
#20
Zhijie Zhang, Rui Li, Lufang Jiang, Chenglong Xiong, Yue Chen, Genming Zhao, Qingwu Jiang
BACKGROUND: Novel avian influenza viruses (AIVs) of H7N9, H10N8, and H5N6 are currently circulating in China's poultry flocks, occasionally infecting human and other mammals. Human infected AIV H5N6 in China during 2014-2015 is believed to be a triple reassortant originated from H6N6 and two clades of H5 viruses. The current report suggests that its reassortment history is more complicated. METHODS: Genomes of human infected isolates of AIV H5N6 were searched from the NCBI Influenza Virus Sequence Database and the Global Initiative on Sharing Avian Influenza Data...
October 25, 2016: BMC Infectious Diseases
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