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Obesity hypoventilation

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https://www.readbyqxmd.com/read/29773292/health-related-quality-of-life-measurement-in-patients-with-chronic-respiratory-failure
#1
REVIEW
Toru Oga, Wolfram Windisch, Tomohiro Handa, Toyohiro Hirai, Kazuo Chin
The improvement of health-related quality of life (HRQL) is an important goal in managing patients with chronic respiratory failure (CRF) receiving long-term oxygen therapy (LTOT) and/or domiciliary noninvasive ventilation (NIV). Two condition-specific HRQL questionnaires have been developed to specifically assess these patients: the Maugeri Respiratory Failure Questionnaire (MRF) and the Severe Respiratory Insufficiency Questionnaire (SRI). The MRF is more advantageous in its ease of completion; conversely, the SRI measures diversified health impairments more multi-dimensionally and discriminatively with greater balance, especially in patients receiving NIV...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29767787/sleep-disordered-breathing-in-c57bl-6j-mice-with-diet-induced-obesity
#2
Thomaz Fleury Curado, Huy Pho, Slava Berger, Candela Caballero-Eraso, Mi-Kyung Shin, Luiz Ubirajara Sennes, Luu Pham, Alan R Schwartz, Vsevolod Y Polotsky
Obesity leads to sleep disordered breathing (SDB), as manifested by recurrent upper airway obstructions during sleep termed obstructive sleep apnea and carbon dioxide retention due to obesity hypoventilation. The objective of this work was to characterize breathing during sleep in C57BL6/J mice with diet-induced obesity. Arterial blood gas was measured in nine obese and nine lean mice during wakefulness. Nine male mice with diet induced obesity and six lean male C57BL/6J mice were head mounted with EEG and EMG electrodes...
May 15, 2018: Sleep
https://www.readbyqxmd.com/read/29734990/exosomal-cargo-properties-endothelial-function-and-treatment-of-obesity-hypoventilation-syndrome-a-proof-of-concept-study
#3
Rakesh Bhattacharjee, Abdelnaby Khalyfa, Ahamed A Khalyfa, Babak Mokhlesi, Leila Kheirandish-Gozal, Isaac Almendros, Eduard Peris, Atul Malhotra, David Gozal
STUDY OBJECTIVES: Longitudinal studies support the usage of positive airway pressure (PAP) therapy in treating obstructive sleep apnea (OSA) to improve cardiovascular disease. However, the anticipated benefit is not ubiquitous. In this study, we elucidate whether PAP therapy leads to immediate improvements on endothelial function, a subclinical marker of cardiovascular status, by examining the effect of circulating exosomes, isolated from patients before and after PAP therapy, on naive endothelial cells...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29728260/anesthesia-in-a-pediatric-patient-with-rohadd-syndrome
#4
E Esparza Isasa, M A Palomero Rodríguez, I Acebedo Bambaren, C Medrano Viñas, D Gil Mayo, F Domínguez Pérez, D Pestaña Lagunas
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) syndrome is a rare entity that is characterised by its onset in healthy children at 2-4 years of age. It is a complex syndrome that includes, among other symptoms, rapid weight gain with hyperphagia, hypothalamic dysfunction, central hypoventilation, and autonomic dysregulation. The case is presented of a 10-year-old boy with a diagnosis of ROHHAD syndrome undergoing insertion of a port-a-cath under general anaesthesia, who developed complications during the anaesthetic procedure related to his illness...
May 1, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29724743/efficacy-of-bilevel-positive-airway-pressure-and-continuous-positive-airway-pressure-therapy-in-patients-with-obesity-hypoventilation-syndrome-protocol-for-systematic-review-and-meta-analysis
#5
Lili Guan, Weiliang Wu, Yating Huo, Xiaoying Li, Bingpeng Guo, Yuqiong Yang, Jiawen Xu, Fangfang Jiang, Luqian Zhou, Rongchang Chen
INTRODUCTION: Obesity hypoventilation syndrome (OHS) is a major respiratory complication caused by severe obesity, being associated with significant morbidity, negative impacts on quality of life and reduced survival if not treated appropriately. Positive airway pressure therapy is the first-line treatment for OHS although the optimal modality remains unclear. The goal of this study is to identify the efficacy of home bilevel positive airway pressure therapy by comparison to continuous positive airway pressure therapy and determine the best strategy for patients with OHS...
May 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29701198/-a-case-of-severe-obstructive-sleep-apnea-hypopnea-syndrome-with-urinary-and-anal-incontinence
#6
Li Zhou, Ruoyun Ouyang, Ping Chen, Hong Luo, Hanmei Liu, Guiqian Liu
A case of a young male patient, who came to the Second Xiangya Hospital, Central South University because of snoring for 10 years and nocturnal gatism for half month, was analyzed retrospectively. He was diagnosed as obstructive sleep apnea hypopnea syndrome (OSAHS) finally. The patient had been diagnosed and treated as stroke in the local hospital, while urinary and anal incontinence were not relieved. It was a dilemma for him to be properly diagnosed and treated. Polysomnography in our hospital revealed apnea hypopnea index (AHI) at 44...
March 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29675134/leptin-and-leptin-resistance-in-the-pathogenesis-of-obstructive-sleep-apnea-a-possible-link-to-oxidative-stress-and-cardiovascular-complications
#7
REVIEW
Slava Berger, Vsevolod Y Polotsky
Obesity-related sleep breathing disorders such as obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS) cause intermittent hypoxia (IH) during sleep, a powerful trigger of oxidative stress. Obesity also leads to dramatic increases in circulating levels of leptin, a hormone produced in adipose tissue. Leptin acts in the hypothalamus to suppress food intake and increase metabolic rate. However, obese individuals are resistant to metabolic effects of leptin. Leptin also activates the sympathetic nervous system without any evidence of resistance, possibly because these effects occur peripherally without a need to penetrate the blood-brain barrier...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29595010/-asthma-and-obesity-preventable-therapeutic-trap-with-careful-follow-up
#8
S Peerboom, R Louis, F Schleich
Nowadays, more and more obese asthmatics visit a pulmonologist. It is proven that overweight stirs up the severity of the bronchopathy. It is a concept that is now anchored in the minds of most modern practitioners. Nevertheless, the idea that in some patients, excess weight can be an independent cause of the persistence of respiratory complaints, is sometimes neglected. This case report is about a severely obese poorly controlled asthmatic man, who turns out to be suffering from a concomitant obesity-hypoventilation syndrome...
March 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29553042/a-rare-cause-of-hypothalamic-obesity-rohhad-syndrome-2-cases
#9
Ülkü Gül Şiraz, Deniz Okdemir, Gül Direk, Leyla Akın, Nihal Hatipoğlu, Mustafa Kendırcı, Selim Kurtoğlu
Rapid-onset obesity with hypoventilation, hypothalamic dysfunction and autonomic dysregulation (ROHHAD) syndrome is a rare disease that is difficult to diagnosis and distinguish from genetic obesity syndromes. The underlying causes of the disease has not been fully explained. Hypothalamic dysfunction causes endocrine problems, respiratory dysfunction and autonomic alterations. There are around 80 reported patients due to lack of recognition. We present two female patient suspected of ROHHAD due to weight gain since early childhood...
March 19, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29548648/genetic-factors-in-sleep-disordered-breathing
#10
REVIEW
Kiminobu Tanizawa, Kazuo Chin
Sleep-disordered breathing (SDB) is characterized by repetitive episodes of decreased or arrested respiratory airflow during sleep. SDB is common and affects approximately 20% of the Japanese general population. Most traits of normal sleep and SDB show familial aggregation, suggesting significant effects of genetic factors. Obstructive sleep apnea (OSA) is the most common type of SDB and has a high heritability. Regardless of high heritability, no risk locus for OSA has reached a genome-wide level of significance (P < 5×10-8 ) in linkage or candidate gene analysis...
March 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29548630/sleep-apnea-morbidity-a-consequence-of-microbial-immune-cross-talk
#11
REVIEW
Nuria Farré, Ramon Farré, David Gozal
Obstructive Sleep Apnea (OSA) has emerged as a highly prevalent public health problem that imposes important mid-term and long-term consequences, namely cardiovascular, metabolic, cognitive and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction during sleep. Recurrent collapse of the upper airway develops with sleep onset, and is associated with both intermittent hypoxemia and sleep fragmentation. The microbiome is a vast and complex polymicrobial ecosystem that coexists with the human organism, and has been identified as playing significant roles in the development of host immunological phenotypes...
March 13, 2018: Chest
https://www.readbyqxmd.com/read/29527742/use-of-autobilevel-ventilation-in-patients-with-obstructive-sleep-apnea-an-observational-study
#12
Pierpaolo Baiamonte, Emilia Mazzuca, Claudia I Gruttad'Auria, Alessandra Castrogiovanni, Claudia Marino, Davide Lo Nardo, Marco Basile, Margherita Algeri, Salvatore Battaglia, Oreste Marrone, Andrea Gagliardo, Maria R Bonsignore
Continuous positive airway pressure (CPAP) is the first-choice treatment for obstructive sleep-disordered breathing. Automatic bilevel ventilation can be used to treat obstructive sleep-disordered breathing when CPAP is ineffective, but clinical experience is still limited. To assess the outcome of titration with CPAP and automatic bilevel ventilation, the charts of 356 outpatients (obstructive sleep apnea, n = 242; chronic obstructive pulmonary disease + obstructive sleep apnea overlap, n = 80; obesity hypoventilation syndrome [OHS], n = 34; 103 females) treated for obstructive sleep-disordered breathing from January 2014 to April 2017 were reviewed...
March 12, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29485929/ventilatory-responses-during-submaximal-exercise-in-children-with-prader-willi-syndrome
#13
Adam M Hyde, Robert G McMurray, Frank A Chavoya, Daniela A Rubin
PURPOSE: Prader-Willi syndrome (PWS) is a genetic neurobehavioral disorder presenting hypothalamic dysfunction and adiposity. At rest, PWS exhibits hypoventilation with hypercapnia. We characterized ventilatory responses in children with PWS during exercise. METHODS: Participants were children aged 7-12 years with PWS (n = 8) and without PWS with normal weight (NW; n = 9, body mass index ≤ 85th percentile) or obesity (n = 9, body mass index ≥ 95th percentile)...
February 27, 2018: Pediatric Exercise Science
https://www.readbyqxmd.com/read/29445537/neural-respiratory-drive-and-cardiac-function-in-patients-with-obesity-hypoventilation-syndrome-following-initiation-of-non-invasive-ventilation
#14
Angelo Onofri, Maxime Patout, Georgios Kaltsakas, Elodie Lhuillier, Sitali Mushemi-Blake, Gill Arbane, Martino F Pengo, Philip Marino, Joerg Steier
Background: Chronic hypercapnic respiratory failure (HRF) in obesity hypoventilation syndrome (OHS) is commonly treated using non-invasive ventilation (NIV). We hypothesised that treatment of OHS would improve neural respiratory drive index (NRDI) and cardiac function. Methods: Fourteen patients (8 females) with OHS, who were admitted for initiation of domiciliary NIV, were prospectively studied. Patients had (mean ± SD): age (53±10 years), body mass index (BMI) (50...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29415556/patterns-of-use-survival-and-prognostic-factors-in-patients-receiving-home-mechanical-ventilation-in-western-australia-a-single-centre-historical-cohort-study
#15
Geak Poh Tan, Nigel McArdle, Satvinder Singh Dhaliwal, Jane Douglas, Clare Siobhan Rea, Bhajan Singh
Home mechanical ventilation (HMV) is used in a wide range of disorders associated with chronic hypoventilation. We describe the patterns of use, survival and predictors of death in Western Australia. We identified 240 consecutive patients (60% male; mean age 58 years and body mass index 31 kg m-2 ) referred for HMV between 2005 and 2010. The patients were grouped into four categories: motor neurone disorders (MND; 39%), pulmonary disease (PULM; 25%, mainly chronic obstructive pulmonary disease), non-MND neuromuscular and chest wall disorders (NMCW; 21%) and the obesity hypoventilation syndrome (OHS; 15%)...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29404183/effects-of-modes-obesity-and-body-position-on-non-invasive-positive-pressure-ventilation-success-in-the-intensive-care-unit-a-randomized-controlled-study
#16
Murat Türk, Müge Aydoğdu, Gül Gürsel
OBJECTIVES: Different outcomes and success rates of non-invasive positive pressure ventilation (NPPV) in patients with acute hypercapnic respiratory failure (AHRF) still pose a significant problem in intensive care units. Previous studies investigating different modes, body positioning, and obesity-associated hypoventilation in patients with chronic respiratory failure showed that these factors may affect ventilator mechanics to achieve a better minute ventilation. This study tried to compare pressure support (BiPAP-S) and average volume targeted pressure support (AVAPS-S) modes in patients with acute or acute-on-chronic hypercapnic respiratory failure...
January 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29388810/knowledge-gaps-in-the-perioperative-management-of-adults-with-obstructive-sleep-apnea-and-obesity-hypoventilation-syndrome-an-official-american-thoracic-society-workshop-report
#17
Najib T Ayas, Cheryl R Laratta, John M Coleman, Anthony G Doufas, Matthias Eikermann, Peter C Gay, Daniel J Gottlieb, Indira Gurubhagavatula, David R Hillman, Roop Kaw, Atul Malhotra, Babak Mokhlesi, Timothy I Morgenthaler, Sairam Parthasarathy, Satya Krishna Ramachandran, Kingman P Strohl, Patrick J Strollo, Michael J Twery, Phyllis C Zee, Frances F Chung
The purpose of this workshop was to identify knowledge gaps in the perioperative management of obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS). A single-day meeting was held at the American Thoracic Society Conference in May, 2016, with representation from many specialties, including anesthesiology, perioperative medicine, sleep, and respiratory medicine. Further research is urgently needed as we look to improve health outcomes for these patients and reduce health care costs. There is currently insufficient evidence to guide screening and optimization of OSA and OHS in the perioperative setting to achieve these objectives...
February 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29384276/-long-term-non-invasive-ventilation-in-chronic-obstructive-pulmonary-disease-patients
#18
Léonore Schopfer, Lena Groenendijk, Jean-Paul Janssens, Alain Bigin Younossian, Laurence Vignaux
Non-invasive ventilation (NIV) is recognized as first line therapy in acute hypercapnic respiratory failure and chronic alveolar hypoventilation caused by several diseases (restrictive thoracic disorders, neuromuscular disease and obesity-hypoventilation syndrome). In Switzerland and other European countries, long-term NIV has also been applied in hypercapnic patients with chronic obstructive pulmonary disease (COPD). However, only recently has conclusive evidence showing benefits of long-term NIV become available...
January 31, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29368899/-obesity-hypoventilation-syndrome-and-pulmonary-hypertension-an-association-little-known-in-mexico
#19
Ernesto Díaz-Domínguez, Martín Rosas-Peralta, Luis Efrén Santos-Martínez, Nielzer Armando Rodríguez-Almendros, José Antonio Magaña-Serrano, Gilberto Pérez-Rodríguez
The obesity hypoventilation syndrome (OHS) refers to the combination of obesity, daytime hypercapnia and sleep-disordered breathing. Obesity has risen to epidemic proportions in the last three decades in the United States, Mexico and Europe. The OHS is associated with obstructive sleep apnea syndrome in 30%. Without treatment, mortality is 46% at 50 months. So in this paper we analyze the OHS, obesity and pulmonary hypertension, the pathophysiology, clinical presentation and diagnosis as well as the treatment, which is aimed at the correction of sleep-disordered breathing and hypoxemia; although there is little experience with the use of specific pulmonary vasodilator drugs...
January 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29306907/new-aspects-in-the-pathomechanism-of-diseases-of-civilization-particularly-psychosomatic-disorders-part-2-chronic-hypocapnia-and-hypercapnia-in-the-medical-practice
#20
Andras Sikter, Zoltan Rihmer, Roberto de Guevara
The authors seek to find new connections between recent results of biology and older theories. This paper aims to assemble the jigsaw puzzle. The theoretical background of the hypothesis was described in the previous issue of the journal (Sikter et al. 2017a). Human stress response often coexists with persistent hypocapnia or hypercapnia - developing via psychosomatic pathomechanism - which can lead to mental and psychosomatic illnesses. Chronic hypocapnia mainly generates hyperarousal disorders which may be reversible for an extended time, however, vicious cycles may start when hypoxia and/or severe somatic diseases are simultaneously present (commonly in the elderly), which conditions often end with death without medical help...
September 2017: Neuropsychopharmacologia Hungarica
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