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Obesity hypoventilation

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https://www.readbyqxmd.com/read/27876089/rapid-onset-obesity-hypoventilation-hypothalamic-dysfunction-autonomic-dysregulation-and-neuroendocrine-tumor-syndrome-with-a-homogenous-enlargement-of-the-pituitary-gland-a-case-report
#1
Lama Aljabban, Lina Kassab, Nour Alhuda Bakoura, Mohammad Fayez Alsalka, Ismaeil Maksoud
BACKGROUND: Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation syndrome is a rare pediatric disorder with a variable sequence of clinical presentations, undefined etiology, and high risk of mortality. Our patient presented an unusual course of the disease accompanied by a homogenous mild enlargement of her pituitary gland with an intact pituitary-endocrine axis which, to the best of our knowledge, represents a new finding in rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation syndrome...
November 22, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27852952/a-randomised-controlled-trial-of-cpap-versus-non-invasive-ventilation-for-initial-treatment-of-obesity-hypoventilation-syndrome
#2
Mark E Howard, Amanda J Piper, Bronwyn Stevens, Anne E Holland, Brendon J Yee, Eli Dabscheck, Duncan Mortimer, Angela T Burge, Daniel Flunt, Catherine Buchan, Linda Rautela, Nicole Sheers, David Hillman, David J Berlowitz
BACKGROUND: Obesity hypoventilation syndrome (OHS) is the most common indication for home ventilation, although the optimal therapy remains unclear, particularly for severe disease. We compared Bi-level and continuous positive airways pressure (Bi-level positive airway pressure (PAP); CPAP) for treatment of severe OHS. METHODS: We conducted a multicentre, parallel, double-blind trial for initial treatment of OHS, with participants randomised to nocturnal Bi-level PAP or CPAP for 3 months...
November 15, 2016: Thorax
https://www.readbyqxmd.com/read/27843344/the-danish-national-database-for-obstructive-sleep-apnea
#3
Poul Jørgen Jennum, Preben Larsen, Charlotte Cerqueira, Thor Schmidt, Philip Tønnesen
AIM: The aim of the Danish National Database for Obstructive Sleep Apnea (NDOSA) was to evaluate the clinical quality (diagnostic, treatment, and management) for obstructive sleep apnea and obesity hypoventilation syndrome in Denmark using a real-time national database reporting to the Danish National Patient Registry. STUDY POPULATION: All patients diagnosed with obstructive sleep apnea or obesity hypoventilation syndrome at public and private in- and out-hospital departments in Denmark were included...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27812378/the-clinical-characteristics-and-hospital-and-post-hospital-survival-of-patients-with-the-obesity-hypoventilation-syndrome-analysis-of-a-large-cohort
#4
P E Marik, C Chen
OBJECTIVE: The worldwide prevalence of obesity has reached epidemic proportions. Obesity hypoventilation syndrome (OHS) is a common yet largely undiagnosed and mistreated condition that likely carries a high mortality. The aim of this study was to determine the clinical characteristics, hospital outcome, outcome following hospital discharge and predictors of death in a large cohort of patients hospitalized with OHS. OHS is an important condition as many patients with this syndrome are misdiagnosed and receive inappropriate treatment...
March 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/27792694/-obesity-and-its-respiratory-effects-detected-through-levels-of-partial-pressure-of-carbon-dioxide-in-the-supine-position
#5
América Sánchez-Medina, Marcela Ma Sánchez-Medina
INTRODUCTION: Obesity is a disease that is closely associated with deleterious respiratory effects such as the Obesity Hypoventilation Syndrome which conventionally includes awake hypercapnia. There are studies addressing the detection of daytime hypercapnia with the patient either in sitting or standing position. However, there are no studies in obese subjects with a normal daytime PaCO2 in whom the detection of hypercapnia is made in the supine position. It is feasible that the physiopathological changes that occur in obese patients when they adopt the supine position lead to increased PaCO2 levels or hypercapnia...
September 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27792079/obesity-hypoventilation-syndrome-sleep-apnea-overlap-syndrome-perioperative-management-to-prevent-complications
#6
Raviraj Raveendran, Jean Wong, Mandeep Singh, David T Wong, Frances Chung
PURPOSE OF REVIEW: The prevalence of sleep disordered breathing (SDB) is increasing proportional to the prevalence of obesity. Although anesthesiologists are familiar with obstructive sleep apnea (OSA) - the most common SDB, anesthesiologists may not be aware of other SDB such as obesity hypoventilation syndrome (OHS) and overlap syndrome (combination of OSA and chronic obstructive pulmonary disease). The present review provides an update of information regarding the perioperative management of OHS and overlap syndrome...
October 26, 2016: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27792077/sleep-sleep-studies-and-sleep-disordered-breathing-basic-knowledge-for-the-anesthesiologist
#7
Andrew P Hall
PURPOSE OF REVIEW: To provide a basic understanding of sleep physiology, the pathophysiology of sleep-disordered breathing and the processes applied in undertaking and assessing sleep studies. RECENT FINDINGS: It has become increasingly apparent that obstructive sleep apnoea is associated with heightened perioperative risk. Furthermore, the condition still remains under-diagnosed in patients presenting for surgery. SUMMARY: This review describes the physiology of sleep including sleep stages, sleep monitoring, the normal hypnogram and investigation from simple overnight pulse oximetry to full polysomnography...
October 26, 2016: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27766147/the-effect-of-positive-airway-pressure-therapy-on-neurocognitive-functions-depression-and-anxiety-in-obesity-hypoventilation-syndrome
#8
Serap Argun Baris, Dilek Tuncel, Cigdem Ozerdem, Huseyin Kutlu, Tugba Onyilmaz, Ilknur Basyigit, Hasim Boyaci, Fusun Yildiz
BACKGROUND: The aim of this study is to evaluate the presence of neurocognitive dysfunctions, depression and anxiety and the effect of positive airway pressure (PAP) therapy on these alterations in Obesity Hypoventilation Syndrome (OHS) patients. METHODS: Ten healthy normal and obese controls, 10 OHS and 10 OSAS patients were included in the study. Short form-36, Beck Depression Scale and State-Trade Anxiety Inventory (STAI 1-2) were performed. Wisconsin Card Sorting Test (WCST), Montreal Cognitive Assessment Scale (MOCA), Enhanced Cued Recall (ECR) and Mini Mental Test (MMT) were used for neurocognitive evaluation...
2016: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/27763403/ethical-challenges-in-the-care-of-the-inpatient-with-morbid-obesity
#9
Paul L Schneider, Zhaoping Li
OBJECTIVE: To provide a thorough analysis of the range of ethical concerns that may present in relation to the care of the morbidly obese inpatient over the course of several years of care. METHODS: A narrative of the patient's complex medical care is given, with particular attention to the recommendations of three separate ethics committee consultations that were sought by his health care providers. An ethical analysis of the relevant issues is given within the Principles of Biomedical Ethics framework, highlighting the principles of autonomy, beneficence, non-maleficence, and justice...
2016: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/27761566/rapid-onset-obesity-hypothalamic-dysfunction-hypoventilation-and-autonomic-dysregulation-in-saudi-arabia
#10
Adel S Al-Harbi, Abdullah Al-Shamrani, Baha A Al-Shawwa
Rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare disease, but could be fatal if not diagnosed early. It mimics many other diseases and it may take few years after the onset of rapid obesity to have the other clinical features. Therefore, any patient with rapid-onset obesity after the age of 2 years should have high index of suspicion and long term follow up. We report a case of ROHHAD in Saudi Arabia and we highlight the clinical features and the importance of early diagnosis and management...
November 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27744642/a-decade-of-domiciliary-non-invasive-ventilation-in-the-west-of-ireland
#11
P Gouda, J Chua, D Langan, T Hannon, A Scott, A O'Regan
BACKGROUND: While domiciliary non-invasive ventilation (NIV) was initially used in the treatment of respiratory failure resulting from chest wall deformity, the main indication is now chronic obstructive pulmonary disease (COPD) with recurrent exacerbations associated with type 2 respiratory failure. A longitudinal study of domiciliary NIV provides insights into the evolution of this treatment in the west of Ireland. METHODS: The cohort of patients receiving new prescriptions for domiciliary NIV from Galway University Hospital from 2000 to 2012 was reviewed using study coordinator chart reviews and telephone follow-ups...
October 15, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/27576233/respiratory-conditions-update-restrictive-lung-disease
#12
H Coleman Robinson
Restrictive lung diseases are a heterogeneous group of conditions characterized by a restrictive pattern on spirometry and confirmed by a reduction in total lung volume. Patients with more severe symptoms may have a reduced diffusing capacity of the lung for carbon monoxide. Etiologies can be intrinsic with lung parenchymal involvement, as in interstitial lung diseases, or extrinsic to the lung, as in obesity and neuromuscular disorders. Idiopathic pulmonary fibrosis is a chronic progressive interstitial pneumonia with fibrosis for which treatment is primarily supportive with oxygen therapy, pulmonary rehabilitation, and management of comorbid conditions...
September 2016: FP Essentials
https://www.readbyqxmd.com/read/27568890/the-effect-of-supplemental-oxygen-in-obesity-hypoventilation-syndrome
#13
Juan F Masa, Jaime Corral, Auxiliadora Romero, Candela Caballero, Joaquin Terán-Santos, Maria L Alonso-Álvarez, Teresa Gomez-Garcia, Mónica González, Soledad López-Martínez, Pilar De Lucas, José M Marin, Sergi Marti, Trinidad Díaz-Cambriles, Eusebi Chiner, Miguel Merchan, Carlos Egea, Ana Obeso, Babak Mokhlesi
STUDY OBJECTIVES: Low flow supplemental oxygen is commonly prescribed to patients with obesity hypoventilation syndrome (OHS). However, there is a paucity of data regarding its efficacy and safety. The objective of this study was to assess the medium-term treatment efficacy of adding supplemental oxygen therapy to commonly prescribed treatment modalities in OHS. METHODS: In this post hoc analysis of a previous randomized controlled trial, we studied 302 sequentially screened OHS patients who were randomly assigned to noninvasive ventilation, continuous positive airway pressure, or lifestyle modification...
October 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27530511/noninvasive-ventilation-in-the-critically-ill-patient-with-obesity-hypoventilation-syndrome-a-review
#14
Telma C A Sequeira, Ahmed S BaHammam, Antonio M Esquinas
Obesity is a global epidemic that adversely affects respiratory physiology. Sleep-disordered breathing and obesity hypoventilation syndrome (OHS) are among the most common pulmonary complications related to obesity class III. Patients with OHS may present with acute hypercapnic respiratory failure (AHRF) that necessitates immediate noninvasive ventilation (NIV) or invasive ventilation and intensive care unit (ICU) monitoring. The OHS is underrecognized as a cause of AHRF. The management of mechanical ventilation in obese ICU patients is one of the most challenging problems facing respirologists, intensivists, and anesthesiologists...
August 15, 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/27523890/-obesity-hypoventilation-syndrome-need-to-diagnose-earlier-and-treat-properly
#15
J M Luo, Y Xiao
No abstract text is available yet for this article.
August 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27495174/non-invasive-ventilation-for-sleep-disordered-breathing-in-smith-magenis-syndrome
#16
Victoria Connor, Sizheng Zhao, Robert Angus
Smith-Magenis syndrome (SMS) is a rare genetic neurodevelopmental disorder characterised by behavioural disturbances, intellectual disability and early onset obesity. The physical features of this syndrome are well characterised; however, behavioural features, such as sleep disturbance, are less well understood and difficult to manage. Sleep issues in SMS are likely due to a combination of disturbed melatonin cycle, facial anatomy and obesity-related ventilatory problems. Sleep disorders can be very distressing to patients and their families, as exemplified by our patient's experience, and can worsen behavioural issues as well as general health...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27473663/rohhad-syndrome-and-evolution-of-sleep-disordered-breathing
#17
Diana Reppucci, Jill Hamilton, E Ann Yeh, Sherri Katz, Suhail Al-Saleh, Indra Narang
BACKGROUND: Rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dysregulation (ROHHAD) is a rare disease with a high mortality rate. Although nocturnal hypoventilation (NH) is central to ROHHAD, the evolution of sleep disordered breathing (SDB) is not well studied. The aim of the study was to assess early manifestations of SDB and their evolution in ROHHAD syndrome. METHODS: Retrospective study of children with ROHHAD at two Canadian centers...
2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27445559/clinical-outcomes-associated-with-home-mechanical-ventilation-a-systematic-review
#18
REVIEW
Erika J MacIntyre, Leyla Asadi, Doug A Mckim, Sean M Bagshaw
Background. The prevalence of patients supported with home mechanical ventilation (HMV) for chronic respiratory failure has increased. However, the clinical outcomes associated with HMV are largely unknown. Methods. We performed a systematic review of studies evaluating patients receiving HMV for indications other than obstructive lung disease, reporting at least one clinically relevant outcome including health-related quality of life (HRQL) measured by validated tools; hospitalization requirements; caregiver burden; and health service utilization...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/27406165/non-invasive-ventilation-in-obesity-hypoventilation-syndrome-without-severe-obstructive-sleep-apnoea
#19
Juan F Masa, Jaime Corral, Candela Caballero, Emilia Barrot, Joaquin Terán-Santos, Maria L Alonso-Álvarez, Teresa Gomez-Garcia, Mónica González, Soledad López-Martín, Pilar De Lucas, José M Marin, Sergi Marti, Trinidad Díaz-Cambriles, Eusebi Chiner, Carlos Egea, Erika Miranda, Babak Mokhlesi, Estefanía García-Ledesma, M-Ángeles Sánchez-Quiroga, Estrella Ordax, Nicolás González-Mangado, Maria F Troncoso, Maria-Ángeles Martinez-Martinez, Olga Cantalejo, Elena Ojeda, Santiago J Carrizo, Begoña Gallego, Mercedes Pallero, M Antonia Ramón, Josefa Díaz-de-Atauri, Jesús Muñoz-Méndez, Cristina Senent, Jose N Sancho-Chust, Francisco J Ribas-Solís, Auxiliadora Romero, José M Benítez, Jesús Sanchez-Gómez, Rafael Golpe, Ana Santiago-Recuerda, Silvia Gomez, Mónica Bengoa
BACKGROUND: Non-invasive ventilation (NIV) is an effective form of treatment in patients with obesity hypoventilation syndrome (OHS) who have concomitant severe obstructive sleep apnoea (OSA). However, there is a paucity of evidence on the efficacy of NIV in patients with OHS without severe OSA. We performed a multicentre randomised clinical trial to determine the comparative efficacy of NIV versus lifestyle modification (control group) using daytime arterial carbon dioxide tension (PaCO2) as the main outcome measure...
October 2016: Thorax
https://www.readbyqxmd.com/read/27396770/reduced-cardiovascular-morbidity-in-obesity-hypoventilation-syndrome-an-ischemic-preconditioning-protective-effect
#20
EDITORIAL
Lena Lavie, Peretz Lavie
No abstract text is available yet for this article.
July 2016: Chest
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