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https://www.readbyqxmd.com/read/29106862/an-investigation-of-operative-outcomes-pediatric-invasive-fungal-sinusitis
#1
Curtis Hanba, Peter F Svider, Wanda Lai, Syed Naweed Raza, Anthony Sheyn, Jean Anderson Eloy, Adam J Folbe
OBJECTIVES/HYPOTHESIS: Invasive fungal sinusitis is an uncommon entity among children. Early recognition is crucial for facilitating successful treatment with minimal morbidity. The goal of this analysis was to identify patient characteristics associated with high-risk surgical disease through a population-based examination into this rare and deadly disease process. METHODS: A retrospective chart review of the 2009 and 2012 Kids' Inpatient Database (KID) was conducted...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29105773/clinical-trials-in-rhinosinusitis-identifying-areas-for-improvement
#2
Tam Ramsey, Wanda Lai, Eric Guo, Peter F Svider, Giancarlo Zuliani, Jean Anderson Eloy, Adam J Folbe
OBJECTIVES/HYPOTHESIS: To characterize trends in rhinosinusitis clinical trials to provide recommendations for therapeutic directions, highlight possible redundancy, and provide a framework for prioritization of future clinical trials. STUDY DESIGN: Database analysis. METHODS: Data were collected from ClinicalTrials.gov including all clinical trials that focused on rhinosinusitis with the exclusion of trials withdrawn prior to enrollment. Variables recorded included study design, study population, pharmaceutical involvement, publication, and whether a trial was a medical or surgical intervention...
November 6, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29047049/comparison-of-imaging-modalities-for-detecting-complications-in-bariatric-surgery
#3
Sergio Susmallian, Eduard Folb, Royi Barnea, Asnat Raziel
PURPOSE: The purpose of this study is to evaluate the results of routine fluoroscopic swallowing study (FSS) imaging 24 h after surgery and computed tomography (CT) on demand based on clinical data, in diagnosing complications after bariatric surgery. MATERIAL AND METHODS: This retrospective study includes 9386 patients that underwent bariatric surgery. A total of 3241 (34.53%) patients underwent FSS imaging following the surgical procedure, and 106 (1.13%) patients underwent CT...
October 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29024520/allergen-immunotherapy-exploring-areas-for-further-inquiry
#4
Tam Ramsey, Wanda Lai, Peter F Svider, Houmehr Hojjat, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: Allergy-related illness impacts millions of individuals worldwide. Our objectives were to characterize current trends of clinical trials research relating to allergen immunotherapy and to describe the landscape of allergen immunotherapy in National Institutes of Health (NIH)-supported research inquiry. METHODS: On ClinicalTrials.gov, the following terms were searched: allergen immunotherapy OR allergy immunotherapy. Variables, including completion status, dates, design, study population, funder, location, and allergen were recorded...
October 12, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28988451/evolving-trends-in-sinus-surgery-what-is-the-impact-of-balloon-sinus-dilation
#5
Peter F Svider, Spencer Darlin, Michael Bobian, Vibhav Sekhsaria, Richard J Harvey, Stacey T Gray, Soly Baredes, Adam J Folbe, Jean Anderson Eloy
OBJECTIVES/HYPOTHESIS: Balloon dilation (BD) represents a minimally invasive alternative to endoscopic sinus surgery (ESS). Although BD was introduced in 2006, distinct Current Procedural Terminology (CPT) codes were not available until 2011, making prior analysis of population-based trends difficult. Our objectives were to evaluate these trends and compare any changes to the use of traditional ESS techniques. Geographic trends also were evaluated. METHODS: Medicare Part B national datasets encompassing procedures from 2011 to 2015 were obtained...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28949251/sialendoscopy-in-the-management-of-radioiodine-induced-sialadenitis-a-systematic-review
#6
REVIEW
Thai-Duong Cung, Wanda Lai, Peter F Svider, Curtis Hanba, Julie Samantray, Adam J Folbe, Mahdi Shkoukani, Syed Naweed Raza
OBJECTIVES: Salivary gland dysfunction as a consequence of radioiodide ablation is present in as many as two-thirds of patients, and unfortunately, many of these individuals do not respond to conservative measures. Sialendoscopy as a minimally invasive therapeutic modality may have utility in the treatment of radioiodide induced sialadenitis (RAIS). Our aim was to explore whether sialendoscopy resulted in clinical improvement in patients with RAIS. METHODS: A systematic review of studies on sialendoscopy for RAIS was conducted using MEDLINE database, Embase, and Cochrane Library...
November 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28881494/pituitary-and-skull-base-lesions-and-the-litigious-patient
#7
Alan C Wang, Spencer Darlin, Wanda Lai, Peter F Svider, Jeffrey T Jacob, James K Liu, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: The objective of this research was to evaluate litigation relating to the diagnosis and management of pituitary and ventral skull base lesions and delineate allegations involved in the decision to pursue medicolegal proceedings. METHODS: Publically available federal and court records were accessed via the Westlaw Next database. Jury verdict and settlement reports relevant to pituitary and anterior skull-base lesions were accessed, and litigation was reviewed for alleged injuries, defendant specialty, patient demographics, and other factors raised in proceedings...
October 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28805174/socioeconomic-position-and-depression-in-south-african-adults-with-long-term-health-conditions-a-longitudinal-study-of-causal-pathways
#8
T Elwell-Sutton, N Folb, A Clark, L R Fairall, C Lund, M O Bachmann
AIMS: There is convincing evidence that lower socioeconomic position is associated with increased risk of mental disorders. However, the mechanisms involved are not well understood. This study aims to elucidate the causal pathways between socioeconomic position and depression symptoms in South African adults. Two possible causal theories are examined: social causation, which suggests that poor socioeconomic conditions cause mental ill health; and social drift, which suggests that those with poor mental health are more likely to drift into poor socioeconomic circumstances...
August 14, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28753718/do-patients-access-appropriate-information-online
#9
Amar Gupta, Michael E Nissan, Dennis I Bojrab, Adam Folbe, Michael A Carron
No abstract text is available yet for this article.
August 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28665550/industry-relationships-are-associated-with-performing-a-greater-number-of-sinus-balloon-dilation-procedures
#10
Jean Anderson Eloy, Peter F Svider, Michael Bobian, Richard J Harvey, Stacey T Gray, Soly Baredes, Adam J Folbe
BACKGROUND: Industry outreach promotes awareness of novel technologies. However, concerns have been raised that such relationships may also unduly impact medical decision-making. Our objective in this study was to evaluate industry relationships among practitioners who frequently employ balloon dilation (BD), characterizing whether there is any association between financial relationships and BD utilization. METHODS: Provider utilization data (FY-2014) was accessed for individuals billing BD procedures to Medicare, the largest healthcare payor in the United States...
September 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28617897/recreational-activity-and-facial-trauma-among-older-adults
#11
Andrea Plawecki, Michael Bobian, Aron Kandinov, Peter F Svider, Adam J Folbe, Jean Anderson Eloy, Michael Carron
Importance: As the US population ages, public health agencies have released guidelines encouraging aerobic activity and muscle-strengthening exercises among older individuals. Facial trauma from such activities among elderly individuals has long been underappreciated. Objectives: To evaluate the incidence of recreational activity-associated facial fractures among older adults and to further delineate injury characteristics including demographics, fracture location, and specific activities...
December 1, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28581126/systemic-therapy-for-head-and-neck-squamous-cell-carcinoma-historical-perspectives-and-recent-breakthroughs
#12
REVIEW
Michael A Blasco, Peter F Svider, S Naweed Raza, John R Jacobs, Adam J Folbe, Pankhoori Saraf, Jean Anderson Eloy, Soly Baredes, Andrew M Fribley
OBJECTIVES: Despite dramatic developments in drugs established for other malignancies, historically there have been few novel systemic agents available for the management of head and neck squamous cell carcinoma (HNSCC). However, the last decade has observed increased interest in targeted therapies for HNSCC. In 2006, cetuximab became the first major drug for HNSCC to gain Food and Drug Administration (FDA) approval in 3 decades. Recently, both pembrolizumab and nivolumab gained FDA approval for treatment of recurrent or metastatic HNSCC, and trials for other indications in HNSCC are actively underway...
November 2017: Laryngoscope
https://www.readbyqxmd.com/read/28570741/association-of-gender-with-financial-relationships-between-industry-and-academic-otolaryngologists
#13
Jean Anderson Eloy, Michael Bobian, Peter F Svider, Ashley Culver, Bianca Siegel, Stacey T Gray, Soly Baredes, Sujana S Chandrasekhar, Adam J Folbe
Importance: Gender disparities continue to exist in the medical profession, including potential disparities in industry-supported financial contributions. Although there are potential drawbacks to industry relationships, such industry ties have the potential to promote scholarly discourse and increase understanding and accessibility of novel technologies and drugs. Objectives: To evaluate whether gender disparities exist in relationships between pharmaceutical and/or medical device industries and academic otolaryngologists...
August 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28377248/is-industry-funding-associated-with-greater-scholarly-impact-among-academic-neurosurgeons
#14
Jean Anderson Eloy, Suat Kilic, Nicholas G Yoo, Thomas Mcleod, Peter F Svider, Soly Baredes, Adam J Folbe, William T Couldwell, James K Liu
OBJECTIVE: To determine the relationship between industry payments and scholarly impact among academic neurosurgeons. METHODS: Faculty names and academic rank data were obtained from department websites, bibliometric data were obtained from the Scopus database, and industry payment data were obtained from the Center for Medicare and Medicaid Services open payments database (openpayments.cms.gov). The h-index was used to estimate scholarly impact. Payments were classified as "general," "associated research," and "research payments...
July 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28369687/caregiver-integration-during-discharge-planning-for-older-adults-to-reduce-resource-use-a-metaanalysis
#15
REVIEW
Juleen Rodakowski, Philip B Rocco, Maqui Ortiz, Barbara Folb, Richard Schulz, Sally C Morton, Sally Caine Leathers, Lu Hu, A Everette James
OBJECTIVES: To determine the effect of integrating informal caregivers into discharge planning on postdischarge cost and resource use in older adults. DESIGN: A systematic review and metaanalysis of randomized controlled trials that examine the effect of discharge planning with caregiver integration begun before discharge on healthcare cost and resource use outcomes. MEDLINE, EMBASE, and the Cochrane Library databases were searched for all English-language articles published between 1990 and April 2016...
August 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28314400/endoscopic-resection-of-clival-malignancies
#16
REVIEW
Adam J Folbe, Peter F Svider, James K Liu, Jean Anderson Eloy
Surgical management of clival lesions presents numerous therapeutic challenges because of the close proximity of surrounding critical structures. With a detailed understanding of the endoscopic endonasal approach and relevant considerations, appropriate lesions can be removed in a safe and minimally invasive manner. Use of this technique as a primary approach represents the standard of care for many lesions at leading skull base centers, although adjunct techniques may be necessary in extensive lesions and those with significant lateral extension...
April 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28301646/traumatic-facial-injuries-among-elderly-nursing-home-residents-never-event-or-frequent-occurrence
#17
Michael Bobian, Nour El-Kashlan, Curtis J Hanba, Peter F Svider, Adam J Folbe, Jean Anderson Eloy, Giancarlo F Zuliani, Michael Carron
Importance: As the nursing home population continues to increase, an understanding of preventable injuries becomes exceedingly important. Although other fall-related injuries have been characterized, little attention has been dedicated to facial trauma. Objectives: To estimate the incidence of facial trauma among nursing home residents and detail mechanisms of injury, injury characteristics, and patient demographic data. Design, Setting, and Participants: The National Electronic Injury Surveillance System was used to calculate a weighted national incidence of facial trauma among individuals older than 60 years from a nationally representative collection of emergency departments from January 1, 2011, through December 31, 2015...
June 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28257847/validation-of-mycobacterium-tuberculosis-dihydroneopterin-aldolase-as-a-molecular-target-for-anti-tuberculosis-drug-development
#18
V C A Falcão, A D Villela, V S Rodrigues-Junior, K Pissinate, P Eichler, A F M Pinto, L A Basso, D S Santos, C V Bizarro
An early step of target validation in antimicrobial drug discovery is to prove that a gene coding for a putative target is essential for pathogen's viability. However, little attention has been paid to demonstrate the causal links between gene essentiality and a particular protein function that will be the focus of a drug discovery effort. This should be considered an important step in target validation since a growing number of proteins are found to exhibit multiple and unrelated tasks. Here, we show that the Mycobacterium tuberculosis (Mtb) folB gene is essential and that this essentiality depends on the dihydroneopterin aldolase/epimerase activities of its protein product, the FolB protein from the folate biosynthesis pathway...
April 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28045631/head-and-neck-cancer
#19
Peter F Svider, Michael A Blasco, S Naweed Raza, Mahdi Shkoukani, Ammar Sukari, George H Yoo, Adam J Folbe, Ho-Sheng Lin, Andrew M Fribley
Despite a considerable expansion in our therapeutic repertoire for management of other malignancies, mortality from head and neck cancer (HNC) has not significantly improved in recent decades. Upon normalizing National Institutes of Health-awarded R01 and R01-equivalent grants by incidence, thyroid cancer ($214) and HNC ($1329) received the fewest funding dollars. Upon adjusting funding totals by mortality, HNC was 7th out of 9 cancers evaluated ($6138). These findings highlight HNC as an underfunded disease versus other cancers...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28012510/pediatric-rhinoplasty-a-discussion-of-perioperative-considerations-and-systematic-review
#20
REVIEW
Amar Gupta, Peter F Svider, Hani Rayess, Anthony Sheyn, Adam J Folbe, Jean Anderson Eloy, Giancarlo Zuliani, Michael A Carron
OBJECTIVES: Pediatric rhinoplasty has traditionally raised numerous concerns, including its impact on growth as well as the psychological sequelae of undergoing a potentially appearance-altering procedure. Our objective was to critically evaluate available individual patient data relevant to pediatric rhinoplasty, and further discuss perioperative considerations. METHODS: A systematic review was conducted using PubMed/MEDLINE databases. Data extracted and analyzed from included studies included patient demographics, surgical indications, operative approaches, outcomes, complications, revision rates, and other clinical considerations...
January 2017: International Journal of Pediatric Otorhinolaryngology
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