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Marat Fudim

Piotr Niewinski, Dariusz Janczak, Artur Rucinski, Stanislaw Tubek, Zoar J Engelman, Pawel Piesiak, Przemyslaw Jazwiec, Waldemar Banasiak, Marat Fudim, Paul A Sobotka, Shahrokh Javaheri, Emma C J Hart, Julian F R Paton, Piotr Ponikowski
AIMS: Augmented reflex responses from peripheral chemoreceptors, which are mainly localized in the carotid bodies (CBs), characterize patients with systolic heart failure and contribute to adrenergic hyperactivation. We investigated whether surgical resection of CBs in these patients can be performed safely to decrease sympathetic tone. METHODS AND RESULTS: We studied 10 male patients with systolic heart failure (age, 59 ± 3 years; LVEF, 27 ± 7%) who underwent unilateral right-sided CB resection (four patients) or bilateral CB resection (six patients)...
September 20, 2016: European Journal of Heart Failure
Robert Pagnanelli, Marat Fudim, Salvador Borges-Neto
No abstract text is available yet for this article.
June 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Marat Fudim, Sreekanth Vemulapalli
Untreated and uncontrolled hypertension (HTN) presents a major public health burden in the USA and worldwide. Despite the known risk for increased cardiovascular (CV) morbidity and mortality, blood pressure remains untreated and uncontrolled at alarming rates of between 20 and 40 % in patients with known HTN. Further, while cumulative evidence indicates that early onset of antihypertensive effect improves CV outcomes, the time to blood pressure (BP) control remains long. The objective of hypertension management cannot be simply to achieve and maintain the goal BP, but to do so quickly to improve short-term and long-term CV outcomes...
April 2016: Current Hypertension Reports
Marat Fudim, Sandip Zalawadiya, Devin K Patel, Ugochukwu O Egolum, Luis Afonso
The current guidelines recommend the new risk score, Atherosclerotic Cardiovascular Disease score (ASCVD), to assess an individual׳s risk of future cardiovascular disease (CVD) events. No data exist on the predictive utility of ASCVD score with the incremental value of coronary artery calcium scoring (CACS) across ethnicities and gender. Multi-Ethnic Study of Atherosclerosis (MESA) is a population based study (n=6814) of White (38%), Black (28%), Chinese (22%) and Hispanic (12%) subjects, aged 45-84 years, free from clinical cardiovascular disease...
March 2016: Data in Brief
Paul L Hess, Linda K Shaw, Marat Fudim, Ami E Iskandrian, Salvador Borges-Neto
BACKGROUND: The prognostic value of left ventricular dyssynchrony measured by gated single-photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI) and its relationship to electrical dyssynchrony measured by QRS duration are incompletely understood. The aim of this study was therefore to examine the independent and incremental prognostic value of dyssynchrony in yet the largest group of patients with coronary artery disease (CAD). METHODS AND RESULTS: Patients presenting for GSPECT- MPI between July 1993 and May 1999 in normal sinus rhythm were identified from the Duke Nuclear Cardiology Databank and the Duke Databank for Cardiovascular Disease (N = 1244)...
January 25, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Marat Fudim, Christopher L Brown, Mary E Davis, Monica Djunaidi, Matthew R Danter, Frank E Harrell, John M Stulak, Nicholas A Haglund, Simon Maltais
Driveline infections (DLI) are a cause of morbidity after continuous-flow left ventricular assist device (CF-LVAD) implantation. Because driveline trauma contributes to DLI, we assessed whether intraoperative placement of a temporary external anchoring suture (EAS) influenced DLI rate. We analyzed 161 consecutive patients with CF-LVAD (HMII 82; HW 79) implantation. Two groups were defined: placement of EAS (n = 85) or No EAS (n = 76). For NO EAS patients, the driveline was permanently anchored internally to the rectus fascia...
May 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Marat Fudim, Sandip Zalawadiya, Devin K Patel, Ugochukwu O Egolum, Luis Afonso
No abstract text is available yet for this article.
February 1, 2016: International Journal of Cardiology
Christopher L Brown, JoAnn Lindenfeld, Marat Fudim
No abstract text is available yet for this article.
December 2015: JAMA Internal Medicine
Marat Fudim, Mary E Davis, Cathy Jenkins, Christopher L Brown, Mark A Wigger, John M Stulak, Simon Maltais, Nicholas Haglund
BACKGROUND: The use of continuous flow (CF) left ventricular assist devices (LVAD) as a bridge to orthotopic heart transplantation (OHT) has increased. This study examined survival outcomes after CF-LVAD explantation and OHT using marginal donors. METHODS: Adults undergoing OHT with or without LVAD explant using marginal donors between 2007 and 2014 were identified in the Scientific Registry for Transplant Recipients database. A previously validated donor risk score was used to define marginal donors...
December 2015: Annals of Thoracic Surgery
Marat Fudim, Joseph L Fredi, Stephen K Ball, Christopher R Ellis
No abstract text is available yet for this article.
January 2016: Journal of Cardiovascular Electrophysiology
Marat Fudim, Kelly L Groom, Cheryl L Laffer, James L Netterville, David Robertson, Fernando Elijovich
Removal of carotid body (CB) improves animal models of hypertension (HTN) and heart failure, via withdrawal of chemoreflex-induced sympathetic activation. Effect of CB tumor (CBT) resection on blood pressure (BP) in subjects with HTN is unknown. A retrospective analysis of 20 subjects with HTN (BP≥140/90 mmHg or anti-hypertensives use) out of 134 with CBT resection. Short-term (30 days from surgery) and long-term (slope of regressions on time over the entire follow-up) changes in BP and heart rate were adjusted for covariates (interval between readings, total follow-up, number of readings and changes in therapy)...
June 2015: Journal of the American Society of Hypertension: JASH
Kelly D Green, Alain Waked, Usman Majeed, Marat Fudim, Mark A Robbins, Marshall Crenshaw, David Zhao
We report the case of an 85-year-old woman with severe aortic stenosis who underwent transcatheter aortic valve replacement with use of the Edwards Sapien(®) valve system. The procedure was complicated by rupture of the valve-deployment balloon, with separation and retention of the nose cone of the RetroFlex 3(®) delivery system in the iliac artery. Our endovascular retrieval of the equipment was successful, and we achieved access-site hemostasis by deploying a covered stent. To our knowledge, this is the first report of the endovascular retrieval of a malfunctioning delivery system during transcatheter aortic valve replacement...
December 2014: Texas Heart Institute Journal
Marat Fudim, Alice Stanton, Paul A Sobotka, Eamon Dolan, Henry Krum
Excess blood pressure remains the most important risk factor for cardiovascular and renal disease. Poly pharmacy has been proved safe and effective under clinical trial circumstances; however, the majority of patients fail to sustain pharmaceutical persistence and adherence. The opportunity to offer patients a treatment or device in addition or perhaps instead of drug therapy alone may significantly broaden the options for patients and allow greater success in hypertensive therapy. In this review, we examine the potential of a fixed-volume central arterial-venous anastomosis to reduce blood pressure in hypertensive patients, review possible mechanisms by which the anastomosis may reduce blood pressure, and consider the unique clinical trial opportunities posed by this therapy...
December 2014: Current Hypertension Reports
Devin K Patel, Kelly D Green, Marat Fudim, Frank E Harrell, Thomas J Wang, Mark A Robbins
BACKGROUND: In an era of expanded treatment options for severe aortic stenosis, it is important to understand risk factors for the condition. It has been suggested that severe aortic stenosis is less common in African Americans, but there are limited data from large studies. METHODS AND RESULTS: The Synthetic Derivative at Vanderbilt University Medical Center, a database of over 2.1 million de-identified patient records, was used to identify individuals who had undergone echocardiography...
June 2014: Journal of the American Heart Association
Georgios Christodoulidis, Timothy J Vittorio, Marat Fudim, Stamatios Lerakis, Constantine E Kosmas
Coronary artery disease (CAD) is the leading cause of death in the United States. Although CAD was formerly considered a lipid accumulation-mediated disease, it has now been clearly shown to involve an ongoing inflammatory response. Advances in basic science research have established the crucial role of inflammation in mediating all stages of CAD. Today, there is convincing evidence that multiple interrelated immune mechanisms interact with metabolic risk factors to initiate, promote, and ultimately activate lesions in the coronary arteries...
November 2014: Cardiology in Review
Marat Fudim, Eugene W Ely, Cheryl L Laffer, Fernando Elijovich
No abstract text is available yet for this article.
July 2014: European Heart Journal
Marat Fudim, Roshanak R Markley, Mark A Robbins
Acutely failing bioprosthetic valves represent a clinical emergency and are exceedingly challenging given the paucity of therapeutic options. Oftentimes, these patients are not re-operative candidates due to clinical instability. We present 2 cases of acute degenerative aortic bioprosthetic valve failure with cardiogenic shock treated with transcatheter aortic valve replacement (TAVR). These cases were characterized by hemodynamic instability with vasopressor dependence and (multiple) organ failure. These 2 cases demonstrate that TAVR should be considered as a treatment option for unstable patients with bioprosthetic failure...
November 2013: Journal of Invasive Cardiology
Sreejit Nair, Ajay Gupta, Marat Fudim, Christopher Robinson, Vinay Ravi, Sandra Hurtado-Rua, Zoar Engelman, Kyungmouk S Lee, C Douglas Phillips, Akhilesh K Sista
INTRODUCTION: The carotid body (CB) has previously been found to be enlarged and hyperactive in various disease states such as heart failure (HF), hypertension (HTN), and respiratory disease. Evaluation of CB size in these disease states using imaging has not been performed. The purpose of this case-control study was to compare CB sizes in patients with HF and HTN with those of controls using CT angiography. METHODS: A retrospective review was performed on 323 consecutive patients who had neck computed tomography angiography (CTA) exams in 2011...
November 2013: Neuroradiology
Marat Fudim, Kelly Daniel Green, Joseph L Fredi, Mark A Robbins, David Zhao
PURPOSE: To report a case of a major vascular complication during transcatheter aortic valve replacement (TAVR) and the endovascular management thereof. Additionally, we discuss a possible correlation with long-term steroid use. CASE REPORT: A 79-year-old woman with a history of critical aortic stenosis underwent elective TAVR. Her procedure was complicated by rupture of her right iliac artery, life-threatening retroperitoneal hemorrhage, and thrombus extending into the distal right lower extremity...
December 2012: Perspectives in Vascular Surgery and Endovascular Therapy
Piotr Niewinski, Zoar J Engelman, Marat Fudim, Stanislaw Tubek, Bartlomiej Paleczny, Ewa A Jankowska, Waldemar Banasiak, Paul A Sobotka, Piotr Ponikowski
AIMS: Augmented peripheral chemoreflex response is an important mechanism in the pathophysiology of chronic heart failure (CHF). This study characterizes prevalence and clinical predictors of this phenomenon in optimally managed male CHF patients, and seeks to describe the hemodynamic consequences of chemoreceptor hypersensitivity. METHODS AND RESULTS: Thirty-four optimally managed CHF patients and 16 control subjects were prospectively studied. Hypoxic ventilatory response (HVR)-a measure of peripheral chemosensitivity-was calculated with the use of short nitrogen gas administrations...
June 2013: Journal of Cardiac Failure
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