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REVIEW
Sandra Nora González-Díaz, Mariano García-Campa, Andrés Noyola-Pérez, Rosa-Ivett Guzmán-Avilán, Cindy Elizabeth de Lira-Quezada, Neri Álvarez-Villalobos, René Rodríguez-Gutiérrez, Carlos Macouzet-Sánchez
BACKGROUND: Randomized Clinical Trials (RCTs) are important tools to establish the effects of a given intervention. Investigators should focus on outcomes that patients perceive: patient-important outcomes (PIOs), clinical endpoints that patients value directly and reflect how they feel, function, or survive. However, it is easier to consider surrogated outcomes to reduce costs and achieve better-looking results. The problem with these outcomes is that they indirectly measure PIOs, which might not correlate linearly or translate reliably into a positive PIO...
April 2023: World Allergy Organization Journal
#22
JOURNAL ARTICLE
Kuan-Wen Su, Dah-Chin Yan, Liang-Shiou Ou, Li-Lun Lin, Chao-Yi Wu, Shu-Jung Huang, Tsung-Chieh Yao, Kuo-Wei Yeh, Jing-Long Huang
BACKGROUND: Food allergies are becoming more prevalent globally. The purpose of this study was to investigate the epidemiology of food allergies in Taiwan. METHODS: In 2017, a food allergy questionnaire was administered to 6-7-year-old children, 13-14-year-old adolescents, and their parents in Taipei. The results were compared to those from a previous survey conducted in 2004. RESULTS: A total of 16,200 questionnaires were completed, revealing a rise in the prevalence of food allergies from 7...
April 29, 2023: Journal of Microbiology Immunology and Infection
#23
REVIEW
Ying Chang, Ying Zhang, Yifan Bai, Run Lin, Yaping Qi, Min Li
AIM: To evaluate the correlation between tic disorders and allergies and to inform strategies for the treatment and prevention of tic disorders. METHODS: We conducted online searches of the MEDLINE, Embase, Cochrane, CNKI, CBM, WanFang, and VIP Information databases. Case-control studies and cohort studies related to tic disorders and allergic conditions were searched. Two researchers screened the literature, extracted data, and evaluated quality in strict accordance with the predetermined retrieval strategy and inclusion criteria...
2023: Frontiers in Pediatrics
#24
JOURNAL ARTICLE
D Christian Fenske, Yuxin Ding, Paula Morrow, Sarah G Smith, Monica K Silver, Meghan Moynihan, Janna Manjelievskaia
BACKGROUND: Alopecia areata (AA) is an autoimmune disease characterized by nonscarring hair loss. AA frequently co-occurs with other inflammatory autoimmune conditions, presenting a significant clinical burden. OBJECTIVE: To compare the burden of illness, direct and indirect costs in adult patients with AA vs atopic dermatitis (AD). METHODS: This retrospective cohort study used US administrative claims data from the Merative MarketScan Commercial Claims and Encounters Database to compare commercially insured adults with AA to those with AD...
April 2023: Journal of Managed Care & Specialty Pharmacy
#25
JOURNAL ARTICLE
Xin Zhou, Wentao Liu, Sulian Yang, Angela Wu, Peiran Chen, Songchao Yin, Sybren de Hoog, Meirong Li, Peiying Feng
BACKGROUND: Tinea capitis, atopic dermatitis, and allergic rhinitis are the most common disorders endured by prepubescent children. Dermatophyte infections have been linked to allergic disorders, such as increased sensitivity to dermatophytes in patients with atopic dermatitis. OBJECTIVES: To explore the correlation between tinea capitis and allergic diseases in children and to analyse their risk factors. METHODS: This study monitored epidemiological changes in childhood tinea capitis and risk factors for whom with allergic disease in a single centre in three consecutive five-year intervals by reviewing clinical data and multivariate logistic data analysis...
December 23, 2022: Mycoses
#26
JOURNAL ARTICLE
Xue-Jiao Qian, Xiao-Tian Hu, Ping Jiang
OBJECTIVE: The present study aims to evaluate the efficacy of an anti-immunoglobulin E monoclonal antibody (omalizumab) in the treatment of allergic asthma (AS). METHODS: A total of 34 patients with moderate-to-severe bronchial asthma admitted to the Respiratory Department of Tianjin First Central Hospital between September 2019 and September 2021 were enrolled in this study. The patients were treated with omalizumab in addition to conventional inhaled corticosteroids + long-acting β2 agonist treatment...
November 24, 2022: Immunology
#27
REVIEW
Courtney L Ramos, Jennifer Namazy
Asthma, allergic rhinitis, chronic urticaria, and atopic dermatitis are common diseases that affect hundreds of thousands of pregnant women each year. The authors discuss the use of biologics in women who are pregnant or lactating, indications, available safety information, and knowledge gaps. There are pregnant patients for which standard treatment is either inadequate or contraindicated; in those cases, monoclonal antibodies (biologics) should be considered despite the unknown risk to the fetus. In severe asthma, omalizumab is the best studied with reassuring available safety data...
February 2023: Immunology and Allergy Clinics of North America
#28
JOURNAL ARTICLE
Yajia Li, Qiangxiang Li, Ziqin Cao, Jianhuang Wu
Objectives: Previous studies have reported a potential association of polyunsaturated fatty acids (PUFAs) levels with allergic disease risk and the possible benefit of PUFAs supplementation on allergic disease prevention. This study was performed to estimate the genetic association between PUFAs and allergic diseases using the method of both univariable and multivariable two-sample Mendelian randomization (MR). Methods: As indicators of the PUFAs levels, we included the omega-3, omega-6, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), linoleic acid (LA), and the ratio of omega-6 to omega-3 (omega-6:3)...
2022: Frontiers in Nutrition
#29
REVIEW
George N Konstantinou, Gerasimos N Konstantinou, Christopher Koulias, Konstantinos Petalas, Michael Makris
The complicated interaction between the central and the autonomic (sympathetic, parasympathetic, and enteric) nervous systems on the one hand and the immune system and its components, on the other hand, seems to substantially contribute to allergy pathophysiology, uncovering an under-recognized association that could have diagnostic and therapeutic potentials. Neurons connect directly with and regulate the function of many immune cells, including mast cells, the cells that have a leading role in allergic disorders...
2022: Journal of Asthma and Allergy
#30
JOURNAL ARTICLE
Lizi Lin, Yujing Chen, Jing Wei, Shengchi Wu, Shu Wu, Jin Jing, Guanghui Dong, Li Cai
BACKGROUND: Green space in the living environment has been linked to the development of allergic diseases. However, evidence regarding early-onset allergy in toddlers was limited, and the critical exposure window remained unclear. We aimed to investigate associations between residential greenness with allergic diseases in early life. METHODS: This prospective birth cohort study included 522 mother-child pairs in Guangzhou, China. We quantified prenatal, postnatal, and early-life (i...
August 2, 2022: Environmental Research
#31
JOURNAL ARTICLE
Ivan Marković, Marina Božan, Tomislav Perković, Katarina Paušek, Vanja Nedeljković, Marina Perković, Tomislav Kelava, Marinko Artuković, Asja Stipić Marković
Concerns have been raised about allergic reactions to messenger ribonucleic acid (mRNA) coronavirus disease 2019 (COVID-19) vaccines. A history of allergic reactions, including anaphylaxis to drugs, has been frequently reported in individuals with anaphylaxis to mRNA vaccines. To estimate the rate of immediate allergic reactions in patients with a history of drug allergy or other allergic disorders. We included adult patients who had received at least 1 dose of an mRNA COVID-19 vaccine at the Special Hospital for Pulmonary Diseases between March 1, 2021, and October 1, 2021, and who reported a history of drug allergy or other allergic diseases (asthma, allergic rhinitis, atopic dermatitis, food or insect venom allergy, mastocytosis, idiopathic anaphylaxis, acute or chronic urticaria, and/or angioedema)...
July 29, 2022: Medicine (Baltimore)
#32
JOURNAL ARTICLE
L L Yi, R F Zhu, L Yang, L T Hu, S C Zhang
To detect the expression of galectin-13 in allergic diseases and provide a new way for the diagnosis and treatment of allergic diseases. A retrospective analysis method was used to screen 216 patients with allergic diseases with house dust mites or aspergillus as allergens who visited the Department of Allergy and Department of Respiratory of Tongji Hospital attached Tongji Medical College, Huazhong University of Science and Technology from March 2018 to May 2021. These allergic diseases included allergic asthma, allergic bronchopulmonary aspergillosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, allergic urticaria...
June 6, 2022: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
#33
JOURNAL ARTICLE
Eustachio Nettis, Luisa Brussino, Vincenzo Patella, Laura Bonzano, Aikaterini Detoraki, Elisabetta Di Leo, Maria Maddalena Sirufo, Cristiano Caruso, Fabio Lodi Rizzini, Mariaelisabetta Conte, Mona-Rita Yacoub, Massimo Triggiani, Erminia Ridolo, Luigi Macchia, Giovanni Rolla, Raffaele Brancaccio, Amato De Paulis, Giuseppe Spadaro, Danilo Di Bona, Angela Maria D'Uggento, Lia Ginaldi, Francesco Gaeta, Eleonora Nucera, Kliljeda Jaubashi, Danilo Villalta, Lorenzo Dagna, Domenico Ciotta, Francesco Pucciarini, Diego Bagnasco, Giorgio Celi, Fulvia Chieco Bianchi, Lorenzo Cosmi, Maria Teresa Costantino, Maria Angiola Crivellaro, Simona D'Alò, Pietro Del Biondo, Stefano Del Giacco, Mario Di Gioacchino, Linda Di Pietro, Elisabetta Favero, Sebastiano Gangemi, Gabriella Guarnieri, Enrico Heffler, Maria Stefania Leto Barone, Carla Lombardo, Francesca Losa, Andrea Matucci, Paola Lucia Minciullo, Paola Parronchi, Giovanni Passalacqua, Stefano Pucci, Oliviero Rossi, Lorenzo Salvati, Michele Schiappoli, Gianenrico Senna, Andrea Vianello, Alessandra Vultaggio, Yang Baoran, Cristoforo Incorvaia, Giorgio Walter Canonica
BACKGROUND: Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects of the cytokines IL-4 and IL-13, that are essential for the Th2 response. Several controlled trials showed that dupilumab is effective and safe in patients with atopic dermatitis (AD), severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), thus resulting in approval by regulatory agencies...
May 19, 2022: Clinical and Molecular Allergy: CMA
#34
REVIEW
Albert C Chong, Won Jong Chwa, Peck Y Ong
PURPOSE OF REVIEW: While aeroallergens are a well-established trigger of asthma and allergic rhinitis, their role in allergic skin diseases such as atopic dermatitis and chronic urticaria remains controversial. This paper reviews the pathophysiology and clinical evidence for aeroallergens in these allergic skin diseases and summarizes current strategies for evaluation and management. RECENT FINDINGS: Current evidence implicates aeroallergens as triggers of cutaneous reactions in atopic dermatitis...
July 2022: Current Allergy and Asthma Reports
#35
REVIEW
Luc Colas, Antoine Magnan, Sophie Brouard
Immunoglobulin E is the latest discovered of immunoglobulin family and has been long associated with anaphylaxis and worm expulsion. Immunoglobulin E, along with mast cells, basophils, and eosinophils, is also a hallmark of type 2 immunity which is dysregulated in numerous diseases such as asthma, rhinitis, atopic dermatitis, and eosinophilic esophagitis in addition to anaphylaxis as aforementioned. However, recent advances have shed light on IgE regulation and memory explaining the low level of free IgE, the scarcity of IgE plasma cells that are mainly short live and the absence of IgE memory B cells in homeostatic conditions...
June 2022: Allergy
#36
REVIEW
Lin Yu, Huishan Zhang, Jianwei Pan, Leping Ye
Allergic and related diseases have a substantial epidemiological impact on the pediatric population. Small molecule-based medicines have been traditionally used to manage the diseases. Omalizumab is the first monoclonal antibody-based medicine used in children's allergy and shows great promises. It binds to free IgE and prevents it from binding to IgE receptors, thus interrupting the IgE-dependent allergic inflammatory cascade. Vast amounts of data demonstrate its effectiveness and well tolerance by patients, including the children...
December 2021: World Allergy Organization Journal
#37
REVIEW
Gladymar Perez Chacon, Jessica Ramsay, Christopher G Brennan-Jones, Marie J Estcourt, Peter Richmond, Patrick Holt, Tom Snelling
BACKGROUND: Atopic diseases are the most common chronic conditions of childhood. The apparent rise in food anaphylaxis in young children over the past three decades is of particular concern, owing to the lack of proven prevention strategies other than the timely introduction of peanut and egg. Due to reported in vitro differences in the immune response of young infants primed with whole-cell pertussis (wP) versus acellular pertussis (aP) vaccine, we systematically appraised and synthesised evidence on the safety and the potential allergy preventive benefits of wP, to inform recommendation for future practice and research...
September 6, 2021: Cochrane Database of Systematic Reviews
#38
JOURNAL ARTICLE
Saad Alhumaid, Abbas Al Mutair, Zainab Al Alawi, Ali A Rabaan, Raghavendra Tirupathi, Mohammed A Alomari, Aqeel S Alshakhes, Abeer M Alshawi, Gasmelseed Y Ahmed, Hassan M Almusabeh, Tariq T Alghareeb, Abdulaziz A Alghuwainem, Zainab A Alsulaiman, Mohammed A Alabdulmuhsin, Emad A AlBuwaidi, Amjad K Bu Dukhi, Hani N Mufti, Manaf Al-Qahtani, Kuldeep Dhama, Jaffar A Al-Tawfiq, Awad Al-Omari
BACKGROUND: Currently there is no systematic review and meta-analysis of the global incidence rates of anaphylactic and nonanaphylactic reactions to SARS-CoV-2 vaccines in the general adult population. OBJECTIVES: To estimate the incidence rates of anaphylactic and nonanaphylactic reactions after COVID-19 vaccines and describe the demographic and clinical characteristics, triggers, presenting signs and symptoms, treatment and clinical course of confirmed cases. DESIGN: A systematic review and meta-analysis...
October 16, 2021: Allergy, Asthma, and Clinical Immunology
#39
JOURNAL ARTICLE
David Price, Andrew Menzies-Gow, Claus Bachert, Giorgio Walter Canonica, Janwillem Kocks, Asif H Khan, Fen Ye, Paul J Rowe, Yufang Lu, Siddhesh Kamat, Victoria Carter, Jaco Voorham
Background: Although prevalence of co-existing type 2 inflammatory diseases (cT2) in asthma patients has been reported, limited data exist regarding their impact on asthma outcomes. Objective: To assess the impact of cT2 burden on asthma outcomes and to evaluate patterns of clustering of cT2 in a real-world setting. Methods: From medical records of 4.5 million enrollees in 650 primary care practices in the UK (January 2010-December 2017), patients with ≥1 diagnosis code for asthma at any time pre-index date (date of most recent asthma-related medical encounter) and ≥2 asthma-related prescriptions during the year before index date were categorized into the Global Initiative of Asthma (GINA) guideline severity steps...
2021: Journal of Asthma and Allergy
#40
REVIEW
Ismail Ogulur, Yagiz Pat, Ozge Ardicli, Elena Barletta, Lacin Cevhertas, Ruben Fernandez-Santamaria, Mengting Huang, Manal Bel Imam, Jana Koch, Siyuan Ma, Debbie J Maurer, Yasutaka Mitamura, Yaqi Peng, Urszula Radzikowska, Arturo O Rinaldi, Juan Rodriguez-Coira, Pattraporn Satitsuksanoa, Stephan R Schneider, Alexandra Wallimann, Damir Zhakparov, Reihane Ziadlou, Marie-Charlotte Brüggen, Willem van de Veen, Milena Sokolowska, Katja Baerenfaller, Luo Zhang, Mubeccel Akdis, Cezmi A Akdis
During the past years, there has been a global outbreak of allergic diseases, presenting a considerable medical and socioeconomical burden. A large fraction of allergic diseases is characterized by a type 2 immune response involving Th2 cells, type 2 innate lymphoid cells, eosinophils, mast cells, and M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on the disease endotypes, clusters, precision diagnoses, identification of therapeutic targets, and monitoring of treatment efficacies...
December 2021: Allergy
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