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Asthma, allergic rhinitis, urticaria, atopic dermatitis

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https://www.readbyqxmd.com/read/27677381/prevalence-and-risk-factors-for-asthma-among-children-aged-0-14-years-in-hangzhou-a-cross-sectional-survey
#1
Dan Xu, Yingshuo Wang, Zhimin Chen, Shuxian Li, Yungai Cheng, Li Zhang, Lingzhi Zhao
BACKGROUND: Asthma is a global problem. Prevalence varies among different countries and cities. We aimed to obtain the prevalence, describe the characteristics, and discover factors that may relate to asthma in Hangzhou. METHODS: This cross-sectional study was conducted in Hangzhou. The subjects were children aged 14 years and younger. A control group of non-asthma children that matched in age and sex with each asthmatic patient was also randomly selected and interviewed...
September 27, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27613653/novel-biologicals-for-the-treatment-of-allergic-diseases-and-asthma
#2
REVIEW
Hern-Tze Tina Tan, Kazunari Sugita, Cezmi A Akdis
PURPOSE OF REVIEW: The development of biological therapies has rapidly progressed during the last few years, and major advances were reported for the treatment of allergic diseases, such as atopic dermatitis, allergic rhinitis, urticaria, food allergy, and asthma. Here, we review biologicals targeting the type 2 immune response involving Th2 cells, type 2 innate lymphoid cells, natural killer T cells, mast cells, basophils, and epithelial cells, such as IL-4, IL-5, IL-13, IL-31, tumor necrosis factor alpha (TNF-α), and thymic stromal lymphopoietin (TSLP)...
October 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27497421/the-association-of-residential-mold-exposure-and-adenotonsillar-hypertrophy-in-children-living-in-damp-environments
#3
Ozlem Atan Sahin, Nuray Kececioglu, Muhittin Serdar, Aysel Ozpinar
BACKGROUND: There are many consequences of mold exposure related to respiratory system health of children This retrospective cohort study aims to find the association between adenoid hypertrophy and mold exposure in children living in damp environments. METHODS: Children with history of recurrent respiratory tract infections were enrolled in the study between June 2012 and June 2013 and were followed up for adenoid hypertrophy from June 2013 to June 2016. One hundred and forty two children were residents of moldy houses and 242 were living in normal houses...
September 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27448446/roles-of-mas-related-g-protein-coupled-receptor-x2-on-mast-cell-mediated-host-defense-pseudoallergic-drug-reactions-and-chronic-inflammatory-diseases
#4
REVIEW
Hariharan Subramanian, Kshitij Gupta, Hydar Ali
Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage, contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However, MCs are best known for their roles in allergic and inflammatory diseases, such as anaphylaxis, food allergy, rhinitis, itch, urticaria, atopic dermatitis, and asthma. In addition to the high-affinity IgE receptor (FcεRI), MCs express numerous G protein-coupled receptors (GPCRs), which are the largest group of membrane receptor proteins and the most common targets of drug therapy...
September 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27339179/is-gianotti-crosti-syndrome-associated-with-atopy-a-case-control-study-and-a-postulation-on-the-intrinsic-host-factors-in-gianotti-crosti-syndrome
#5
Antonio Chuh, Vijay Zawar, Albert Lee, Gabriel Sciallis
OBJECTIVES: To investigate whether Gianotti-Crosti syndrome (GCS) in children is associated with atopy. METHODS: The setting was two outpatient clinic. Diagnoses of asthma and atopic dermatitis (AD) were made according to internationally accepted diagnostic criteria. Allergic rhinitis, atopic urticaria, and allergic conjunctivitis were diagnosed clinically. Participants were children with GCS diagnosed over the previous 5 years. For any child with GCS, we extracted the record of the subsequent age and sex pair-matched child seen for problems unrelated to the skin as controls...
September 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27333777/lipid-mediators-of-allergic-disease-pathways-treatments-and-emerging-therapeutic-targets
#6
REVIEW
Eric Schauberger, Miriam Peinhaupt, Tareian Cazares, Andrew W Lindsley
Bioactive lipids are critical regulators of inflammation. Over the last 75 years, these diverse compounds have emerged as clinically-relevant mediators of allergic disease pathophysiology. Animal and human studies have demonstrated the importance of lipid mediators in the development of asthma, allergic rhinitis, urticaria, anaphylaxis, atopic dermatitis, and food allergy. Lipids are critical participants in cell signaling events which influence key physiologic (bronchoconstriction) and immune phenomena (degranulation, chemotaxis, sensitization)...
July 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27286483/birth-month-and-risk-of-atopic-dermatitis-a-nationwide-population-based-study
#7
C L Kuo, T L Chen, C C Liao, C C Yeh, C L Chou, W R Lee, J G Lin, C C Shih
BACKGROUND: An individual's birth month has been associated with allergic diseases, but little is known about the association between birth month and atopic dermatitis (AD). OBJECTIVE: The aim of this study was to investigate the risk of AD in children born in various months. METHODS: Using Taiwan's National Health Insurance Research Database, we conducted a case-control study that included 31 237 AD cases and 124 948 age- and gender-matched controls without AD...
June 10, 2016: Allergy
https://www.readbyqxmd.com/read/27264564/association-of-wider-neck-circumference-and-asthma-in-obese-children
#8
Onur Akın, Erkan Sarı, Mutluay Arslan, Ediz Yeşilkaya, Bulent Hacihamdioglu, Suleyman Tolga Yavuz
BACKGROUND: Obesity is a well-established risk factor for asthma. Previous studies have reported that central obesity is associated with asthma. OBJECTIVE: To investigate the association between fat distribution, which is determined by anthropometric measures, including neck circumference (NC), and asthma in school-aged children. METHODS: Children diagnosed as having asthma were enrolled along with controls who were admitted to our outpatient department with allergic symptoms, such as rhinitis, urticaria and atopic dermatitis...
June 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27177276/co-morbidities-and-cognitive-status-in-a-cohort-of-teenagers-with-asthma
#9
Shlomo Cohen, Neville Berkman, Elie Picard, Tali Levi, Estela Derazne, Dorit Tzur, Chaim Springer, Avraham Avital, Leon Joseph, Shmuel Goldberg
BACKGROUND: There is limited data regarding co-morbidities and cognitive status of asthma during childhood and adolescence. The aim of the current study was to explore the presence of co-morbidities and cognitive status in a large cohort of teenagers with asthma. METHODS: The medical records of 314,897 consecutive 17-year-old males, undergoing comprehensive medical and cognitive evaluation prior to recruitment for military service, were reviewed. The prevalence of co-morbidities and a cognitive assessment in subjects with asthma were compared to those without asthma...
September 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27090058/treating-ige-mediated-diseases-via-targeting-ige-expressing-b-cells-using-an-anti-c%C3%AE%C2%B5mx-antibody
#10
REVIEW
Sean S Liour, Andrew Tom, Yueh-Hsuan Chan, Tse Wen Chang
Targeting the IgE pathway is a clinically validated strategy for treating IgE-mediated diseases. Omalizumab, an anti-IgE antibody, which binds to free IgE and prevents the binding of IgE to FcεRI on mast cells and basophils has been approved for severe persistent allergic asthma and chronic spontaneous (idiopathic) urticaria. The therapeutic efficacy of anti-IgE has also been reported in allergic rhinitis, allergic bronchopulmonary aspergillosis, latex allergy, atopic dermatitis, allergic urticaria, anaphylaxis, and others...
August 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27035379/preschoolers-with-allergic-diseases-have-an-increased-risk-of-irritable-bowel-syndrome-when-reaching-school-age
#11
Teck-King Tan, An-Chyi Chen, Cheng-Li Lin, Te-Chun Shen, Tsai-Chung Li, Chang-Ching Wei
OBJECTIVES: To systemically investigate the risk of subsequent irritable bowel syndrome (IBS) in children with antecedent allergic diseases in a population-based case-control study in Taiwan. METHODS: We evaluated 11,242 children (age range: 7-18 years) with IBS and 44,968 age- and sex-matched control subjects who had been examined between 2000 and 2008. IBS odds ratios (ORs) were calculated for children with antecedent allergic diseases, including allergic conjunctivitis (AC), allergic rhinitis (AR), asthma, atopic dermatitis (AD), urticaria, and food allergy (FA)...
March 28, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26976119/emerging-concepts-mast-cell-involvement-in-allergic-diseases
#12
REVIEW
Brian D Modena, Kristen Dazy, Andrew A White
In a process known as overt degranulation, mast cells can release all at once a diverse array of products that are preformed and present within cytoplasmic granules. This occurs typically within seconds of stimulation by environmental factors and allergens. These potent, preformed mediators (ie, histamine, heparin, serotonin, and serine proteases) are responsible for the acute symptoms experienced in allergic conditions such as allergic conjunctivitis, allergic rhinitis, allergy-induced asthma, urticaria, and anaphylaxis...
August 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/26955442/epidemiological-survey-of-pediatric-food-allergy-in-mashhad-in-northeast-iran
#13
Hamid Ahanchian, Seyedali Jafari, Fatemeh Behmanesh, Nasrinsadat Motevalli Haghi, Alireza Ataei Nakhaei, Mohammad Ali Kiani, Mohammad Hossein Radbin, Hamidreza Kianifar
INTRODUCTION: Food allergy is an increasing problem worldwide, but the foods responsible for food allergy are not the same in different countries, probably because of the role of genetic, cultural, and nutritional factors. The aim of this study was to determine the common food allergens in pediatric patients with different presentation of food allergy. METHODS: In this cross-sectional study, all of the patients were referred to pediatric allergy clinics affiliated with Mashhad University of Medical Sciences from September 2012 to August 2014...
January 2016: Electronic Physician
https://www.readbyqxmd.com/read/26954777/the-adapar-birth-cohort-study-food-allergy-results-at-five-years-and-new-insights
#14
Dilek Doğruel, Gülbin Bingöl, Mustafa Yılmaz, Derya Ufuk Altıntaş
BACKGROUND: Although food allergy (FA) is often a transient condition during childhood, when and in whom FA will resolve can be affected by many factors. In this study, we analyzed the data at 5 years on 33 children diagnosed with FA in the ADAPAR (Adana Pediatric Allergy Research) birth cohort study in southern Turkey. METHODS: Thirty-three infants detected as having FA at the end of their first year in the ADAPAR study were assessed every 6 months until the age of 5 years...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/26483075/management-of-allergic-disease-in-the-elderly-key-considerations-recommendations-and-emerging-therapies
#15
REVIEW
Maria Teresa Ventura, Nicola Scichilone, Matteo Gelardi, Vincenzo Patella, Erminia Ridolo
The number of people over 65 is increasing around the world. At present, between 5 and 10% of allergic diseases affect the elderly. In particular, rhinitis is increasing worldwide; the presence of high comorbidity makes the therapy of asthma even more complicated. With reference to dermatological allergies, the dryness of the skin favors the onset of allergic contact and atopic dermatitis, while the senescence of mucous membranes and the impaired secretion of polymeric IgA could be linked to food allergy. Overcoming the problem of adverse drug reaction is limited by the diagnostic difficulty in patients taking multiple drugs...
2015: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/26240792/immunoglobulin-e-to-allergen-components-of-house-dust-mite-in-korean-children-with-allergic-disease
#16
Hwan Soo Kim, Sung Hee Kang, Sulmui Won, Eu Kyoung Lee, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Jin Tack Kim
BACKGROUND: House dust mites (HDMs) are important sources of indoor allergens. Seventeen components have been identified from Dermatophagoides pteronyssinus (Der p). OBJECTIVE: Our aim was to define the prevalence of specific IgE to components of Der p in Korea and investigate the clinical features of them in children with allergic disease. METHODS: We performed a prospective evaluation of 80 HDM sensitized patients with history of allergic rhinitis (AR), atopic dermatitis (AD), asthma and urticaria (UC)...
July 2015: Asia Pacific Allergy
https://www.readbyqxmd.com/read/26048266/off-label-uses-of-omalizumab
#17
David El-Qutob
The off-label use of medicines is a common and extensive clinical practice. Omalizumab has been licensed for use in severe allergic asthma and chronic urticaria. Omalizumab dosing was based on body weight and baseline serum IgE concentration. All patients are required to have a baseline IgE between 30 and 700 IU/ml and body weight not more than 150 kg. The use of off-label drugs may lead to several problems including adverse effects and an increased risk/benefit balance. In this article, there are summarized off-label uses of omalizumab in the last recent years in diseases in which IgE maybe or certainly has a corner role such as allergic rhinitis, allergic bronchopulmonary aspergillosis, anaphylaxis, keratoconjunctivitis, food allergy, drug allergy, urticaria, angioedema, non-atopic asthma, atopic dermatitis, nasal polyps, Churg-Strauss syndrome, eosinophilic otitis media, chronic rhinosinusitis, bullous pemphigoid, contact dermatitis, and others...
February 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/25965316/cracking-the-egg-an-insight-into-egg-hypersensitivity
#18
REVIEW
Pathum Dhanapala, Chamika De Silva, Tim Doran, Cenk Suphioglu
Hypersensitivity to the chicken egg is a widespread disorder mainly affecting 1-2% of children worldwide. It is the second most common food allergy in children, next to cow's milk allergy. Egg allergy is mainly caused by hypersensitivity to four allergens found in the egg white; ovomucoid, ovalbumin, ovotransferrin and lysozyme. However, some research suggests the involvement of allergens exclusively found in the egg yolk such as chicken serum albumin and YGP42, which may play a crucial role in the overall reaction...
August 2015: Molecular Immunology
https://www.readbyqxmd.com/read/25950455/neonatal-jaundice-and-risks-of-childhood-allergic-diseases-a-population-based-cohort-study
#19
Chang-Ching Wei, Cheng-Li Lin, Te-Chun Shen, Chia-Hung Kao
BACKGROUND: Only a few studies have systemically analyzed the association between neonatal jaundice and childhood-onset allergic diseases. METHODS: From 2000 to 2007, 27,693 neonates with newly diagnosed neonatal jaundice and 55,367 matched nonneonatal jaundice cohorts were identified. The incidences and hazard ratios (HRs) of five allergic diseases, namely allergic conjunctivitis (AC), allergic rhinitis (AR), atopic dermatitis (AD), asthma, and urticaria, by the end of 2008 were calculated...
August 2015: Pediatric Research
https://www.readbyqxmd.com/read/25782404/keratoconus-and-allergic-diseases-among-israeli-adolescents-between-2005-and-2013
#20
Ilan Merdler, Ayal Hassidim, Nir Sorkin, Shachar Shapira, Yoav Gronovich, Zfania Korach
PURPOSE: The aim of this study was to evaluate the association between keratoconus (KC) and common allergic conditions, such as asthma, atopic dermatitis, and allergic rhinitis in a large-scale database-based epidemiological study. METHODS: We conducted a cross-sectional study to estimate the epidemiologic relationship between KC and allergic diseases. The study population included all Israeli adolescents who underwent medical evaluation by the Israeli Defense Force, between the years 2005 and 2013...
May 2015: Cornea
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