Jingmei Xiao, Jing Huang, Yujun Long, Xiaoyi Wang, Ying Wang, Ye Yang, Gangrui Hei, Mengxi Sun, Jin Zhao, Li Li, Tiannan Shao, Weiyan Wang, Dongyu Kang, Chenchen Liu, Peng Xie, Yuyan Huang, Renrong Wu, Jingping Zhao
Introduction: Affecting ~1% of the world population, schizophrenia is known as one of the costliest and most burdensome diseases worldwide. Antipsychotic medications are the main treatment for schizophrenia to control psychotic symptoms and efficiently prevent new crises. However, due to poor compliance, 74% of patients with schizophrenia discontinue medication within 1.5 years, which severely affects recovery and prognosis. Through research on intra and interindividual variability based on a psychopathology-neuropsychology-neuroimage-genetics-physiology-biochemistry model, our main objective is to investigate an optimized and individualized antipsychotic-treatment regimen and precision treatment for first-episode schizophrenic patients...
2021: Frontiers in Psychiatry