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https://www.readbyqxmd.com/read/27886982/impact-of-norepinephrine-weight-based-dosing-compared-with-non-weight-based-dosing-in-achieving-time-to-goal-mean-arterial-pressure-in-obese-patients-with-septic-shock
#1
Nina Vadiei, Mitchell J Daley, Manasa S Murthy, Carrie S Shuman
BACKGROUND: Currently, a lack of standardization exists in norepinephrine dosing units, the first-line vasopressor for septic shock. Timely achievement of goal mean arterial pressure (MAP) is dependent on optimal vasopressor dosing. OBJECTIVE: To determine if weight-based dosing (WBD) of norepinephrine leads to earlier time to goal MAP compared with non-WBD in obese patients with septic shock. METHODS: This was a retrospective, multicenter cohort study...
November 24, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27727528/evaluation-of-new-onset-atrial-fibrillation-in-severe-sepsis-and-septic-shock
#2
Rajmadhangi D
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27467907/incidence-predictors-and-outcomes-of-new-onset-atrial-fibrillation-in-critically-ill-patients-with-sepsis-a-cohort-study
#3
Peter M C Klein Klouwenberg, Jos F Frencken, Sanne Kuipers, David S Y Ong, Linda M Peelen, Lonneke A van Vught, Marcus J Schultz, Tom van der Poll, Marc J Bonten, Olaf L Cremer
RATIONALE: Patients admitted to intensive care units with sepsis are prone to developing cardiac dysrhythmias, most commonly atrial fibrillation. OBJECTIVES: We determined the incidence, risk factors and outcomes of atrial fibrillation in a cohort of critically ill patients with sepsis. METHODS: We assessed the association between atrial fibrillation and mortality using time-dependent competing risks survival analysis. Subsequently, for development of a risk score estimating the probability of a first occurrence of atrial fibrillation within the following 24 hours, we performed logistic regression analysis...
July 28, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27380528/association-of-heart-rate-with-n-terminal-pro-b-type-natriuretic-peptide-in-septic-patients-a-prospective-observational-cohort-study
#4
Naoki Hayase, Miyuki Yamamoto, Toshifumi Asada, Rei Isshiki, Naoki Yahagi, Kent Doi
BACKGROUND: Excessive sympathetic stress has multiple adverse effects during critical illness including sepsis. Recent studies showed that heart rate control had a significant effect on reducing mortality in septic shock patients. Furthermore, elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in septic patients were reportedly associated with adverse outcome. However, no study has evaluated the relationship between hemodynamic profiles of septic patients and the circulating cardiac biomarker...
July 1, 2016: Shock
https://www.readbyqxmd.com/read/26877443/co-10-are-hospitalised-patients-aged-90-years-and-over-treated-well-for-hypertension-lessons-from-a-prospective-survey
#5
J Bohlender, J Nussberger, B Bohlender
BACKGROUND: Hypertension increases dramatically with age. In clinically stable nonagenarians, ESH guidelines would recommend lowering blood pressure (BP) to 140-150mmHg systolic (SBP) and <90mmHg diastolic (DBP) if it is higher, but it is not clear if all of the oldest old comply with or need these goals. We prospectively analysed antihypertensive treatment decisions and BP outcome in a rural primary care hospital. METHODS: All patients aged >89 years with BP medication admitted to the medical ward were prospectively included over 12 months...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26822890/left-atrial-appendage-morphology-echocardiographic-characterization-procedural-data-and-in-hospital-outcome-of-patients-receiving-left-atrial-appendage-occlusion-device-implantation-a-prospective-observational-study
#6
Christian Fastner, Michael Behnes, Benjamin Sartorius, Mustafa Yildiz, Kambis Mashayekhi, Ibrahim El-Battrawy, Ralf Lehmann, Stefan Baumann, Tobias Becher, Martin Borggrefe, Ibrahim Akin
BACKGROUND: Implantation of left atrial appendage (LAA) occlusion devices was shown to be a feasible and effective alternative to oral anticoagulation in patients with non-valvular atrial fibrillation. However, only few data about in-hospital and peri-procedural data are currently available. This study aims to report about echocardiographic, procedural and in-hospital data of patients receiving LAA occlusion devices. METHODS: This single-center, prospective and observational study includes consecutively patients being eligible for percutaneous implantation of LAA occlusion devices (either Watchman™ or Amplatzer™ Cardiac Plug 2)...
January 28, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/26691173/phase-ii-study-of-capecitabine-in-substitution-of-5-fu-in-the-chemoradiotherapy-regimen-for-patients-with-localized-squamous-cell-carcinoma-of-the-anal-canal
#7
Suilane Coelho Ribeiro Oliveira, Camila Motta Venchiarutti Moniz, Rachel Riechelmann, Alexandra Kichfy Alex, Maria Ignez Braghirolli, Giovanni Bariani, Caio Nahas, Paulo Marcelo Gehm Hoff
UNLABELLED: This was a phase II study of capecitabine in substitution of 5-fluorouracil (5-FU) in the chemoradiotherapy regimen for patients with localized squamous cell carcinoma of the anal canal. BACKGROUND: Combined chemoradiation with infusional 5-FU and mitomycin is the standard treatment for localized squamous cell carcinoma (SCC) of the anal canal. Capecitabine is an oral fluoropirimidine that has been shown to be equally effective to 5-FU in many solid tumors...
March 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/26640039/ibrutinib-in-combination-with-rituximab-in-relapsed-or-refractory-mantle-cell-lymphoma-a-single-centre-open-label-phase-2-trial
#8
Michael L Wang, Hun Lee, Hubert Chuang, Nicolaus Wagner-Bartak, Frederick Hagemeister, Jason Westin, Luis Fayad, Felipe Samaniego, Francesco Turturro, Yasuhiro Oki, Wendy Chen, Maria Badillo, Krystle Nomie, Maria DeLa Rosa, Donglu Zhao, Laura Lam, Alicia Addison, Hui Zhang, Ken H Young, Shaoying Li, David Santos, L Jeffrey Medeiros, Richard Champlin, Jorge Romaguera, Leo Zhang
BACKGROUND: Ibrutinib is approved in the EU, USA, and other countries for patients with mantle cell lymphoma who received one previous therapy. In a previous phase 2 study with single-agent ibrutinib, the proportion of patients who achieved an objective response was 68%; 38 (34%) of 111 patients had transient lymphocytosis. We hypothesised that adding rituximab could target mantle cell lymphoma cells associated with redistribution lymphocytosis, leading to more potent antitumour activity...
January 2016: Lancet Oncology
https://www.readbyqxmd.com/read/26541953/major-publications-in-the-critical-care-pharmacotherapy-literature-january-december-2014
#9
Sarah A Day, Michaelia Cucci, Molly E Droege, Jenna M Holzhausen, Bridgette Kram, Shawn Kram, Mehrnaz Pajoumand, Christine R Parker, Mona K Patel, Gregory J Peitz, Alia Poore, Charles J Turck, Megan A Van Berkel, Adrian Wong, Amanda Zomp, Megan A Rech
PURPOSE: Nine recently published articles and one guideline with important implications for critical care pharmacy practice are summarized. SUMMARY: The Critical Care Pharmacotherapy Literature Update (CCPLU) group includes more than 40 experienced critical care pharmacists across the United States. Group members monitor 29 peer-reviewed journals on an ongoing basis to identify literature relevant to pharmacy practice in the critical care setting. After evaluation by CCPLU group members, selected articles are chosen for summarization and distribution to group members nationwide based on applicability to practice, relevance, and study design and strength...
November 15, 2015: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/26512582/current-epidemiology-and-outcome-of-infective-endocarditis-a-multicenter-prospective-cohort-study
#10
MULTICENTER STUDY
Patricia Muñoz, Martha Kestler, Arístides De Alarcon, José María Miro, Javier Bermejo, Hugo Rodríguez-Abella, Maria Carmen Fariñas, Manuel Cobo Belaustegui, Carlos Mestres, Pedro Llinares, Miguel Goenaga, Enrique Navas, José Antonio Oteo, Paola Tarabini, Emilio Bouza
The aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE).From January 2008, multidisciplinary teams have prospectively collected all consecutive cases of IE, diagnosed according to the Duke criteria, in 25 Spanish hospitals.Overall, 1804 patients were diagnosed. The median age was 69 years (interquartile range, 55-77), 68.0% were men, and 37.1% of the cases were nosocomial or health care-related IE...
October 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26180432/the-comparison-of-stroke-volume-variation-with-central-venous-pressure-in-predicting-fluid-responsiveness-in-septic-patients-with-acute-circulatory-failure
#11
Santhalakshmi Angappan, Satyen Parida, Arumugam Vasudevan, Ashok Shankar Badhe
PURPOSE: The present study was designed to investigate the efficacy of stroke volume variation (SVV) in predicting fluid responsiveness and compare it to traditional measures of volume status assessment like central venous pressure (CVP). METHODS: Forty-five mechanically ventilated patients in sepsis with acute circulatory failure. Patients were not included when they had atrial fibrillation, other severe arrhythmias, permanent pacemaker, or needed mechanical cardiac support...
July 2015: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/26158528/septic-shock-community-acquired-pneumonia-new-onset-atrial-fibrillation-and-intensive-care-unit-outcomes
#12
Bing Xue, Karan Chugh, Ravinder Bhanot, Abdulghani Sankari
No abstract text is available yet for this article.
September 1, 2015: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/25965915/incidence-and-predictors-of-new-onset-atrial-fibrillation-in-septic-shock-patients-in-a-medical-icu-data-from-7-day-holter-ecg-monitoring
#13
Charles Guenancia, Christine Binquet, Gabriel Laurent, Sandrine Vinault, Rémi Bruyère, Sébastien Prin, Arnaud Pavon, Pierre-Emmanuel Charles, Jean-Pierre Quenot
PURPOSE: We investigated incidence, risk factors for new-onset atrial fibrillation (NAF), and prognostic impact during septic shock in medical Intensive Care Unit (ICU) patients. METHODS: Prospective, observational study in a university hospital. Consecutive patients from 03/2011 to 05/2013 with septic shock were eligible. Exclusion criteria were age <18 years, history of AF, transfer with prior septic shock. Included patients were equipped with long-duration (7 days) Holter ECG monitoring...
2015: PloS One
https://www.readbyqxmd.com/read/25914828/epidemiology-prevention-and-treatment-of-new-onset-atrial-fibrillation-in-critically-ill-a-systematic-review
#14
Takuo Yoshida, Tomoko Fujii, Shigehiko Uchino, Masanori Takinami
BACKGROUND: Atrial fibrillation (AF) is a common arrhythmia in the ICU. The aim of this review is to summarize relevant information on new-onset AF in non-cardiac critical illness with respect to epidemiology, prevention, and treatment. METHODS: We conducted a PubMed search in June 2014 and included studies describing the epidemiology, prevention, and treatment of new-onset AF and atrial flutter during ICU stay in non-cardiac adult patients. Selected studies were divided into the three categories according to the extracted information...
2015: Journal of Intensive Care
https://www.readbyqxmd.com/read/25498795/incidence-risk-factors-and-outcomes-of-new-onset-atrial-fibrillation-in-patients-with-sepsis-a-systematic-review
#15
REVIEW
Sanne Kuipers, Peter M C Klein Klouwenberg, Olaf L Cremer
INTRODUCTION: Critically ill patients with sepsis are prone to develop cardiac dysrhythmias, most commonly atrial fibrillation (AF). Systemic inflammation, circulating stress hormones, autonomic dysfunction, and volume shifts are all possible triggers for AF in this setting. We conducted a systematic review to describe the incidence, risk factors and outcomes of new-onset AF in patients with sepsis. METHODS: MEDLINE, EMBASE and Web Of Science were searched for studies reporting the incidence of new-onset AF, atrial flutter or supraventricular tachycardia in patients with sepsis admitted to an intensive care unit, excluding studies that primarily focused on postcardiotomy patients...
December 15, 2014: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25334444/progressive-embolic-infarction-secondary-to-air-emboli-from-atrioesophageal-fistula-status-post-left-atrial-ablation-for-atrial-fibrillation-a-case-report
#16
Louis Moyer
Miscellaneous Cases ISESSION TYPE: Affiliate Case Report SlidePRESENTED ON: Sunday, October 26, 2014 at 10:45 AM - 12:00 PMINTRODUCTION: Atrioesophageal fistula (AEF) is a life-threatening complication of left atrial ablation for atrial fibrillation. AEF resulting in embolic stroke is rare and difficult to recognize, but prompt diagnosis may increase options for repair and survival.CASE PRESENTATION: A 70-year-old female with a PMH significant for atrial fibrillation on warfarin underwent two left atrial ablations within 10 days...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25303755/risk-factors-for-death-among-critically-ill-elderly-patients
#17
Gisele Collyer Alves, Geraldo Bezerra da Silva Júnior, Rafael Siqueira Athayde Lima, Juliana Barbosa Sobral, Rosa Maria Salani Mota, Krasnalhia Lívia Soares de Abreu, Natália Albuquerque Rocha, Charlys Barbosa Nogueira, Elizabeth De Francesco Daher
BACKGROUND: The elderly population is increasing all over the world. The need of intensive care by the elderly is also increasing. There is a lack of studies investigating the risk factors for death among critically ill elderly patients. This study aims to investigate the factors associated with death in a population of critically ill elderly patients admitted to an intensive care unit in Brazil. METHODS: This is a retrospective cohort study including all elderly patients (>60 years) admitted to an intensive care unit in Fortaleza, Brazil, from January to December 2007...
June 2010: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/25013875/outcomes-of-atrioesophageal-fistula-following-catheter-ablation-of-atrial-fibrillation-treated-with-surgical-repair-versus-esophageal-stenting
#18
COMPARATIVE STUDY
Sanghamitra Mohanty, Pasquale Santangeli, Prasant Mohanty, Luigi Di Biase, Chintan Trivedi, Rong Bai, Rodney Horton, J David Burkhardt, Javier E Sanchez, Jason Zagrodzky, Shane Bailey, Joseph G Gallinghouse, Patrick M Hranitzky, Albert Y Sun, Richard Hongo, Salwa Beheiry, Andrea Natale
INTRODUCTION: Atrioesophageal fistula (AEF) is a rare but devastating complication of radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF). Surgical repair and esophageal stents are available treatment options for AEF. We report outcomes of these 2 management strategies. METHODS: Nine patients with AEF post-RFCA for AF were included in this study. AEF was diagnosed based on symptoms and chest CT imaging. Of the 9 patients, 5 received stents and 4 underwent surgical repair of fistula...
June 2014: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/24635770/high-versus-low-blood-pressure-target-in-patients-with-septic-shock
#19
RANDOMIZED CONTROLLED TRIAL
Pierre Asfar, Ferhat Meziani, Jean-François Hamel, Fabien Grelon, Bruno Megarbane, Nadia Anguel, Jean-Paul Mira, Pierre-François Dequin, Soizic Gergaud, Nicolas Weiss, François Legay, Yves Le Tulzo, Marie Conrad, René Robert, Frédéric Gonzalez, Christophe Guitton, Fabienne Tamion, Jean-Marie Tonnelier, Pierre Guezennec, Thierry Van Der Linden, Antoine Vieillard-Baron, Eric Mariotte, Gaël Pradel, Olivier Lesieur, Jean-Damien Ricard, Fabien Hervé, Damien du Cheyron, Claude Guerin, Alain Mercat, Jean-Louis Teboul, Peter Radermacher
BACKGROUND: The Surviving Sepsis Campaign recommends targeting a mean arterial pressure of at least 65 mm Hg during initial resuscitation of patients with septic shock. However, whether this blood-pressure target is more or less effective than a higher target is unknown. METHODS: In a multicenter, open-label trial, we randomly assigned 776 patients with septic shock to undergo resuscitation with a mean arterial pressure target of either 80 to 85 mm Hg (high-target group) or 65 to 70 mm Hg (low-target group)...
April 24, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/24364017/levosimendan-current-data-clinical-use-and-future-development
#20
REVIEW
M S Nieminen, S Fruhwald, L M A Heunks, P K Suominen, A C Gordon, M Kivikko, P Pollesello
Levosimendan is an inodilator indicated for the short-term treatment of acutely decompensated severe chronic heart failure, and in situations where conventional therapy is not considered adequate. The principal pharmacological effects of levosimendan are (a) increased cardiac contractility by calcium sensitisation of troponin C, (b) vasodilation, and (c) cardioprotection. These last two effects are related to the opening of sarcolemmal and mitochondrial potassium-ATP channels, respectively. Data from clinical trials indicate that levosimendan improves haemodynamics with no attendant significant increase in cardiac oxygen consumption and relieves symptoms of acute heart failure; these effects are not impaired or attenuated by the concomitant use of beta-blockers...
2013: Heart, Lung and Vessels
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