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Allergen immunotherapy

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https://www.readbyqxmd.com/read/29930483/sublingual-grass-allergen-specific-immunotherapy-a-retrospective-study-of-clinical-outcome-and-discontinuation
#1
Christer Janson, Fredrik Sundbom, Peter Arvidsson, Mary Kämpe
Background: Sublingual immunotherapy (SLIT) is effective, tolerable, and convenient for many allergic patients. Still, real-world evidence is scarce and the aim of this study is to assess the patient reported outcome of treatment with SLIT against grass pollen allergy in a consecutive patient population. Methods: Patients (n = 329) who were confirmed to be allergic to timothy grass and had been prescribed SLIT were consecutively enrolled in the study and completed a questionnaire online or in hard copy...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29924613/food-allergen-epitope-mapping
#2
Changqi Liu, Shridhar Krishna Sathe
With the increased global awareness and rise in food allergies, a multifold interest in food allergens is evident. The presence of undeclared food allergens results in expensive food recalls and increase risks of anaphylaxis for the sensitive individuals. Regardless of the allergenic food, the immunogen needs to be identified and detected before making any efforts to inactivate/eliminate it. In type I food allergies, protein immunogen cross-links IgEs leading to basophil/mast cell degranulation resulting in the symptoms that range from mild irritation to anaphylaxis...
June 20, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29921463/sublingual-immunotherapy-of-house-dust-mite-respiratory-allergy-in-china
#3
REVIEW
L Cheng, W-C Zhou
Sublingual immunotherapy (SLIT) has been widely used for the treatment of allergic respiratory diseases, but many problems remain unsolved. Currently available data suggest that SLIT is very effective in children and adults with IgE-mediated respiratory diseases. Most allergists in China generally believe that SLIT is suitable for allergic rhinitis and asthma due to its safety and tolerability. SLIT for three years is suitable for patients to acquire stable therapeutic effects, and the efficacy of single-allergen SLIT for polysensitized patients has also been confirmed...
June 16, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29920810/animal-models-of-allergen-specific-immunotherapy-in-food-allergy-overview-and-opportunities
#4
Jeppe Madura Larsen, Katrine Lindholm Bøgh
Food allergy is an adverse reaction to otherwise harmless proteins in food. The disease is a major health problem of growing concern, affecting approximately 5-8% of young children and 2-4% of adults. No accepted strategy exists for prevention and treatment of food allergy, and strict avoidance of the offending food is presently the only viable management option. Living with food avoidance may have a huge impact on the quality of life of food allergic patients, with daily fear of serious or even fatal reactions...
June 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29914679/barley-produced-culicoides-allergens-are-suitable-for-monitoring-the-immune-response-of-horses-immunized-with-e-coli-expressed-allergens
#5
Sigridur Jonsdottir, Sara Bjork Stefansdottir, Sæmundur Bjarni Kristinarson, Vilhjalmur Svansson, Jon Mar Bjornsson, Arna Runarsdottir, Bettina Wagner, Eliane Marti, Sigurbjorg Torsteinsdottir
Insect bite hypersensitivity is an allergic dermatitis of horses caused by bites of Culicoides midges. Sufficient amount of pure, endotoxin-free allergens is a prerequisite for development and monitoring of preventive and therapeutic allergen immunotherapy. Aims of the study were to compare the Culicoides nubeculosus (Cul n) allergens Cul n 3 and Cul n 4, produced in transgenic barley grains with the corresponding E. coli or insect cells expressed proteins for measuring antibody and cytokine responses. Allergen-specific IgG responses were measured by ELISA in sera from twelve horses not exposed to Culicoides, before and after vaccination with E...
July 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29911320/an-open-study-on-the-efficacy-of-a-recombinant-der-f-2-dermatophagoides-farinae-immunotherapy-in-atopic-dogs-in-hungary-and-switzerland
#6
Nina Fischer, Noémi Tarpataki, Federica Leidi, Ana Rostaher, Claude Favrot
BACKGROUND: Previously published studies evaluating a recombinant Der f 2-based immunotherapy have demonstrated efficacy in the treatment of dogs experimentally and naturally sensitized to house dust mites (HDM). Der f 2 sensitization is thought to play a minor role in European atopic dogs sensitized to HDM. OBJECTIVE: The study evaluated the short-term efficacy of a recombinant Der f 2 product in the treatment of naturally sensitized atopic dogs in Switzerland and Hungary...
June 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29909507/what-is-the-relationship-between-eosinophilic-esophagitis-eoe-and-aeroallergens-implications-for-allergen-immunotherapy
#7
REVIEW
Maureen Egan, Dan Atkins
PURPOSE OF REVIEW: Observations suggesting that aeroallergens trigger eosinophilic esophagitis (EoE) in a subset of patients raise questions about the implications this finding has on the evaluation and management of patients with EoE, including a potential role for allergen immunotherapy. RECENT FINDINGS: The majority of studies evaluating the potential role of aeroallergens as provocateurs of EoE have addressed this issue by assessing the seasonal variation in EoE diagnosis and/or symptom onset or worsening, with mixed results...
June 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29909233/phenotype-analyses-of-il-10-producing-foxp3-cd4-t-cells-increased-by-subcutaneous-immunotherapy-in-allergic-airway-inflammation
#8
Masaya Matsuda, Yuki Morie, Hirotaka Oze, Kana Doi, Tatsuya Tsutsumi, Junpei Hamaguchi, Miki Inaba, Takeshi Nabe
INTRODUCTION: The mechanisms of allergen immunotherapy are not fully elucidated. Here, we sought to develop a murine model to demonstrate the effectiveness of subcutaneous immunotherapy (SCIT) for allergic responses. As excessive antigen dosages may induce immune tolerance in sensitized mice, the effects of SCIT were assessed by varying the antigen dosage. The mechanisms of SCIT were analyzed by focusing on the induction of Foxp3+ Treg cells and IL-10-producing Foxp3- CD4+ T cells, as well as on the phenotype of the latter cells...
June 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29908547/oral-immunotherapy-to-wheat-in-allergic-asthmatic-female-a-case-report
#9
Ioana Adriana Muntean, Ioana Corina Bocsan, Diana Deleanu
Wheat is the most commonly grown cereal. Immunological reaction to wheat may be IgE or T-cell- mediated. Asthma could be induced by inhaled flour or by exposure to allergens present in bakery products. In patients with IgE-mediated allergy to wheat proteins there is no specific therapy, except oral immunotherapy (OIT). There are few data regarding OIT with wheat protein in allergic patients. We present a case of a 32-yearold female patient, who worked for 5 years in wheat and bakery products industry, who developed an occupational asthma and chronic urticaria after flour inhalation or ingestion of foods that containit...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29908546/sublingual-immunotherapy-with-sal-k1-expressing-lactococcus-lactis-down-regulates-th2-immune-responses-in-balb-c-mice
#10
Ziba Ghasemi, Abdol-Reza Varasteh, Malihe Moghadam, Seyed-Amir Jalali, Ali Anissian, Mojtaba Sankian
Sublingual immunotherapy (SLIT) has been introduced as a noninvasive and safer approach for allergen-specific immunotherapies. In this study we investigated the efficacy of oral immunotherapy with recombinant Salsola kali 1 protein (Sal k 1) on Th1/Th2 balance in a mouse model of allergy. Female Balb/c mice were intraperitoneally sensitized with rSal k1, followed by a respiratory challenge with 1% (w/v) rSal k1. The sensitized mice were subjected to SLIT using rSal K1 expressing Lactobacillus lactis strain for three weeks...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29908212/intralymphatic-immunotherapy-with-two-concomitant-allergens-birch-and-grass-a-rdbpc-trial
#11
Laila Hellkvist, Eric Hjalmarsson, Susanna Kumlien Georén, Agnetha Karlsson, Karin Lundkvist, Ola Winqvist, Ulla Westin, Lars Olaf Cardell
Intralymphatic immunotherapy (ILIT) with only three lymph node-injections was performed with a combination of grass and birch allergen, with maintained safety and reduced reactivity at nasal grass allergen challenge.
June 13, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29906527/induction-of-bystander-tolerance-and-immune-deviation-following-fel-d-1-peptide-immunotherapy
#12
Daniel M Moldaver, Mantej S Bharhani, Christopher D Rudulier, Jennifer Wattie, Mark D Inman, Mark Larché
BACKGROUND: Treatment of cat allergic subjects with peptides derived from Fel d 1 (the major cat allergen) ameliorated symptoms of cat allergy in phase 2 clinical trials. OBJECTIVE: To demonstrate that the tolerance induced by Fel d 1 peptide immunotherapy can be exploited to reduce allergic responses to a second allergen, ovalbumin (OVA), in mice dually sensitized to OVA and Fel d 1. METHODS: The induction of tolerance to OVA was achieved via a simultaneous exposure to both allergens following peptide treatment...
June 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29900607/local-allergic-rhinitis-implications-for-management
#13
Paloma Campo, Ibon Eguiluz-Gracia, Gador Bogas, María Salas, Carmen Plaza Serón, Natalia Pérez, C Mayorga, M J Torres, Mohammed Shamji, Carmen Rondon
A significant proportion of rhinitis patients without systemic IgE-sensitization tested by skin prick test and serum allergen-specific IgE (sIgE) display nasal reactivity upon nasal allergen provocation test (NAPT). This disease phenotype has been termed local allergic rhinitis (LAR). LAR is an underdiagnosed entity affecting children and adults from different parts of the world, with moderate-to-severe symptoms, impairment of quality of life and rapid progression to symptom worsening. LAR is a stable phenotype and not merely an initial state of AR...
June 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29886521/next-generation-of-allergen-specific-immunotherapies-molecular-approaches
#14
REVIEW
Mirela Curin, Musa Khaitov, Alexander Karaulov, Leyla Namazova-Baranova, Raffaela Campana, Victoria Garib, Rudolf Valenta
PURPOSE OF REVIEW: The aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation molecular AIT approaches and of their clinical evaluation. Furthermore, we discuss the potential of next generation molecular AIT forms for the treatment of severe manifestations of allergy and mention possible future molecular strategies for the secondary and primary prevention of allergy. RECENT FINDINGS: AIT has important advantages over symptomatic forms of allergy treatment but its further development is limited by the quality of the therapeutic antigen preparations which are derived from natural allergen sources...
June 9, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29885036/role-of-sublingual-immunotherapy-in-the-treatment-of-asthma-an-updated-systematic-review
#15
Sandra Y Lin, Antoine Azar, Catalina Suarez-Cuervo, Gregory B Diette, Emily Brigham, Jessica Rice, Murugappan Ramanathan, Karen A Robinson
BACKGROUND: The purpose of the systematic review is to evaluate the efficacy and safety of sublingual immunotherapy (SLIT) for the treatment of allergic asthma. METHODS: PubMed, Embase, and CENTRAL databases were searched, updating an earlier review (January 1, 2005 through May 8, 2017). Randomized, controlled studies (RCTs) were included, which reported one of the prespecified outcomes: asthma symptoms measured by control composite scores; quality of life; medication use; pulmonary physiology; and health-care utilization...
June 9, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29873045/allergen-immunotherapy-tunisian-society-of-respiratory-diseases-and-allergology-guidelines
#16
Fatma Tritar, Majed Béji, A Ben Khedher, Mohamed Ridha Charfi, A El Kamel, K Rekik, H Daghfous, J Ammar, S Azabi, Z Souissi, S Taktak, Ikram Drira, M Smaoui, Boubaker Zakhama
No abstract text is available yet for this article.
August 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29870462/does-evidence-support-the-use-of-cat-allergen-immunotherapy
#17
Sangeeta Dhami, Arnav Agarwal
PURPOSE OF REVIEW: Cat allergy can manifest as allergic rhinitis, conjunctivitis and/or asthma. With widespread cat ownership and exposure, cat allergy has emerged as a major cause of morbidity. Cat allergen immunotherapy is a potential disease modifying treatment for patients with cat allergy. We examine evidence on the effectiveness, cost-effectiveness and safety of cat allergen immunotherapy and consider the clinical contexts in which it should be prescribed. RECENT FINDINGS: The European Association of Allergy and Clinical Immunology systematic reviews on allergic rhinitis and asthma along with the accompanying guidelines on allergic rhinitis were used as primary sources of evidence...
June 4, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29867934/exposure-of-intestinal-epithelial-cells-to-short-and-long-chain-fructo-oligosaccharides-and-cpg-oligodeoxynucleotides-enhances-peanut-specific-t-helper-1-polarization
#18
Simone M Hayen, Henny G Otten, Saskia A Overbeek, André C Knulst, Johan Garssen, Linette E M Willemsen
Background: Non-digestible oligosaccharides promote colonization of beneficial gut bacteria and have direct immunomodulatory effects. Apical exposure of intestinal epithelial cells (IECs) to short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS) in a transwell co-culture model enhanced the CpG-induced (TLR-9 ligand) T helper 1 (Th1) phenotype and regulatory IL-10 response of underlying peripheral mononuclear cells (PBMCs) of healthy donors. scGOS is derived from lactose and may pose risks in severe cow's milk allergic patients, and scFOS/lcFOS may be an alternative...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29859333/real-world-experience-with-peanut-oral-immunotherapy-lessons-learned-from-270-patients
#19
Richard L Wasserman, Angela R Hague, Deanna M Pence, Robert W Sugerman, Stacy K Silvers, Joanna G Rolen, Morley Herbert
BACKGROUND: Peanut allergy (PA) is a significant and increasing problem, interfering with psychological development and family life. The standard recommendation to avoid peanut products and have access to injectable epinephrine is often inadequate. Oral immunotherapy for PA has been formally studied. Clinical observations of allergen immunotherapy have repeatedly enhanced patient care. OBJECTIVE: The purpose of this study is to report observations on the treatment of 270 PA patients over 8...
May 30, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29858582/antigen-specific-regulatory-t-cell-responses-against-aeroantigens-and-their-role-in-allergy
#20
REVIEW
Petra Bacher, Alexander Scheffold
The mucosal immune system of the respiratory tract is specialized to continuously monitor the external environment and to protect against invading pathogens, while maintaining tolerance to innocuous inhaled particles. Allergies result from a loss of tolerance against harmless antigens characterized by formation of allergen-specific Th2 cells and IgE. Tolerance is often described as a balance between harmful Th2 cells and various types of protective "regulatory" T cells. However, the identity of the protective T cells in healthy vs...
June 1, 2018: Mucosal Immunology
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