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Allergen immunotherapy

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https://www.readbyqxmd.com/read/28544523/the-effect-of-allergen-immunotherapy-in-the-onset-of-new-sensitizations-a-meta-analysis
#1
REVIEW
Gabriele Di Lorenzo, Maria Stefania Leto-Barone, Simona La Piana, Antonella Plaia, Danilo Di Bona
BACKGROUND: Although the preventive efficacy of allergen immunotherapy (AIT) in the onset of new allergen sensitizations has been asserted by many reviews, position papers, and consensus conferences, the evidence available is from only 3 studies. The objective of this work was a systematic review to evaluate the preventive efficacy of AIT in the onset of new allergen sensitizations. The end-point was the risk difference (RD) in the onset of new allergen sensitizations between patients treated with AIT and pharmacotherapy...
May 23, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28543086/allergen-immunotherapy-for-allergic-asthma-a-systematic-review-and-meta-analysis
#2
REVIEW
Sangeeta Dhami, Artemisia Kakourou, Felix Asamoah, Ioana Agache, Susanne Lau, Jutel Marek, Antonella Muraro, Graham Roberts, Cezmi A Akdis, Matteo Bonini, Ozlem Cavkaytar, Breda Flood, Pawel Gajdanowicz, Kenji Izuhara, Ömer Kalayci, Ralph Mosges, Oscar Palomares, Oliver Pfaar, Sylwia Smolinska, Milena Sokolowska, Miqdad Asaria, Gopal Netuveli, Hader Zaman, Ather Akhlaq, Aziz Sheikh
BACKGROUND: To inform the development of the European Academy of Allergy and Clinical Immunonology's (EAACI) Guidelines on Allergen Immunotherapy (AIT) for allergic asthma, we assessed the evidence on the effectiveness, cost-effectiveness and safety of AIT. METHODS: We performed a systematic review, which involved searching nine databases. Studies were screened against pre-defined eligibility criteria and critically appraised using established instruments. Data were synthesized using random-effects meta-analyses...
May 19, 2017: Allergy
https://www.readbyqxmd.com/read/28540507/treatment-satisfaction-during-sublingual-immunotherapy-with-a-five-grass-pollen-tablet-for-allergic-rhinoconjunctivitis-a-prospective-non-interventional-study
#3
Udo Schäfer, Andrea Kienle-Gogolok, Meike Hadler, Efstrathios Karagiannis, Sylvia Schnitzer
BACKGROUND: Sublingual immunotherapy (SLIT) is a safe/well-tolerated alternative to allergen injection immunotherapy for allergic rhinoconjunctivitis (ARC). Patient adherence is essential and patient-related outcome measures including treatment satisfaction are informative/indicative of adherence. OBJECTIVE: The aim was to assess treatment satisfaction with five-grass pollen tablet SLIT under real-life conditions. METHODS: Treatment satisfaction among adults taking SLIT with a five-grass pollen tablet for grass pollen-related ARC was assessed with QUARTIS, a self-report questionnaire dedicated to the management of patients treated with SLIT for ARC...
May 24, 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/28535932/charting-novel-allergens-from-date-palm-pollen-phoenix-sylvestris-using-homology-driven-proteomics
#4
Bodhisattwa Saha, Naren Pandey, Swati Gupta Bhattacharya
Pollen grains from Phoenix sylvestris (date palm), a commonly cultivated tree in India has been found to cause severe allergic diseases in an increasing percentage of hypersensitive individuals. To unearth its allergenic components, pollen protein were profiled by two-dimensional gel electrophoresis followed by immunoblotting with date palm pollen sensitive patient sera. Allergens were identified by MALDI-TOF/TOF employing a layered proteomic approach combining conventional database dependent search and manual de novo sequencing followed by homology-based search as Phoenix sylvestris is unsequenced...
May 20, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28535924/molecular-features-of-grass-allergens-and-development-of-biotechnological-approaches-for-allergy-prevention
#5
REVIEW
Deborah L Devis, Janet M Davies, Dabing Zhang
Allergic diseases are characterized by elevated allergen-specific IgE and excessive inflammatory cell responses. Among the reported plant allergens, grass pollen and grain allergens, derived from agriculturally important members of the Poaceae family such as rice, wheat and barley, are the most dominant and difficult to prevent. Although many allergen homologs have been predicted from species such as wheat and timothy grass, fundamental aspects such as the evolution and function of plant pollen allergens remain largely unclear...
May 20, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28533901/allergic-respiratory-disease-ard-setting-forth-the-basics-proposals-of-an-expert-consensus-report
#6
Ana M Navarro, Julio Delgado, Rosa M Muñoz-Cano, M Teresa Dordal, Antonio Valero, Santiago Quirce
BACKGROUND: The variability of symptoms observed in patients with respiratory allergy often hampers classification based on the criteria proposed in guidelines on rhinitis and asthma. OBJECTIVES: We assessed specific aspects of allergic respiratory disease (ARD) that are not explicitly addressed in the guidelines in order to issue specific recommendations and thus optimize clinical practice. METHODS: Using the Delphi technique, 40 Spanish allergists were surveyed to reach consensus on 71 items related to ARD...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28532654/flexible-ige-epitope-containing-domains-of-phl-p-5-cause-high-allergenic-activity
#7
Christoph Göbl, Margarete Focke-Tejkl, Nazanin Najafi, Evelyne Schrank, Tobias Madl, Simone Kosol, Christoph Madritsch, Yulia Dorofeeva, Sabine Flicker, Josef Thalhamer, Rudolf Valenta, Klaus Zangger, Nico Tjandra
This is the first study determining the three-dimensional structure of Phl p 5a which reveals a novel mechanism for high allergenic activity based on flexibly connected IgE-reactive domains which cross-link effector cell-bound IgE more efficiently than isolated rigid globular proteins. These findings may also form a basis for specific immunotherapy strategies.
May 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28532268/allergen-immunotherapy-in-allergic-rhinitis-current-use-and-future-trends
#8
Ludger Klimek, Oliver Pfaar, Jean Bousquet, Gabriela Senti, Thomas Kündig
Type-1 allergies are among the most chronic common diseases of humans. Allergen immunotherapy (AIT) is the only causative and disease-modifying treatment option besides allergen avoidance. Severe systemic adverse allergic reactions may be induced by every AIT treatment. Different approaches have been used to provide safer AIT preparations to lower or even totally overcome this risk. Areas covered: A structured literature recherche in Medline and Pubmed under inclusion of national and international guidelines and Cochrane meta-analyses has been performed aiming at reviewing clinical use of such approaches in AIT...
May 23, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28526774/preliminary-evaluation-of-cytosine-phosphate-guanine-oligodeoxynucleotides-bound-to-gelatine-nanoparticles-as-immunotherapy-for-canine-atopic-dermatitis
#9
I Wagner, K J Geh, M Hubert, G Winter, K Weber, J Classen, C Klinger, R S Mueller
Cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) are a promising new immunotherapeutic treatment option for canine atopic dermatitis (AD). The aim of this uncontrolled pilot study was to evaluate clinical and immunological effects of gelatine nanoparticle (GNP)-bound CpG ODN (CpG GNP) on atopic dogs. Eighteen dogs with AD were treated for 8 weeks (group 1, n=8) or 18 weeks (group 2, n=10). Before inclusion and after 2 weeks, 4 weeks, 6 weeks (group 1+2), 8 weeks, 12 weeks and 16 weeks (group 2) 75 µg CpG ODN/dog (bound to 1...
May 19, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28526624/guideline-recommendations-on-the-use-of-allergen-immunotherapy-in-house-dust-mite-allergy-time-for-a-change
#10
Moisés A Calderón, Jean Bousquet, G Walter Canonica, Lars-Olaf Cardell, Dolores Hernandez Fernandez de Rojas, Jörg Kleine-Tebbe, Pascal Demoly
Guidelines on the treatment of asthma, allergic rhinitis (AR) and allergen immunotherapy (AIT) lack recommendations for house dust mite (HDM) allergy. An expert panel reviewed current guidelines in the light of new data, to assess whether guidelines could be improved. Most guidelines and key position papers did not provide specific recommendations on treatment of allergic asthma (AA) caused by HDM allergy, although some included AIT as a treatment option for AA in general. Around half of the guidelines stated that AIT with HDM extract was an effective treatment for AR, with several indicating sublingual immunotherapy (SLIT) as an option...
May 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28525399/allergen-immunotherapy-for-the-treatment-of-respiratory-allergies-in-the-elderly
#11
Gyu-Young Hur, Ji-Ho Lee, Hae-Sim Park
PURPOSE OF REVIEW: Respiratory allergies, including asthma and allergic rhinitis can also occur in the elderly. Allergen immunotherapy for allergic diseases is the only disease-modifying treatment for patients with allergies available thus far. Here, we review current evidence supporting the use of allergen immunotherapy in the elderly and discuss its efficacy and utility for the treatment of respiratory allergic diseases in this setting. RECENT FINDINGS: Subcutaneous and/or sublingual immunotherapy are effective therapeutic options in not only young but also older patients...
May 17, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28506846/allergen-specific-immunotherapy-modulates-the-balance-of-circulating-tfh-and-tfr-cells
#12
Veronique Schulten, Victoria Tripple, Grégory Seumois, Yu Qian, Richard H Scheuermann, Zheng Fu, Michela Locci, Sandy Rosales, Pandurangan Vijayanand, Alessandro Sette, Rafeul Alam, Shane Crotty, Bjoern Peters
Follicular helper T cells (Tfh cells) are a CD4 T cell subset essential for germinal center formation and B cell responses, although their role in allergy and allergen-specific immunotherapy (AIT) is unclear. Here, we show that AIT-treated patients have a higher ratio of regulatory Tfh cells (Tfr) to follicular T cells (Tfh) and hypothesize an IL-2 dependent mechanism.
May 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28503403/diagnostics-in-hymenoptera-venom-allergy-current-concepts-and-developments-with-special-focus-on-molecular-allergy-diagnostics
#13
Thilo Jakob, David Rafei-Shamsabadi, Edzard Spillner, Sabine Müller
BACKGROUND: The high rate of asymptomatic sensitization to Hymenoptera venom, difficulty in correctly identifying Hymenoptera and loss of sensitization over time make an accurate diagnosis of Hymenoptera venom allergy challenging. Although routine diagnostic tests encompassing skin tests and the detection of venom-specific IgE antibodies with whole venom preparations are reliable, they offer insufficient precision in the case of double sensitized patients or in those with a history of sting anaphylaxis, in whom sensitization cannot be proven or only to the presumably wrong venom...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/28502519/-blomia-tropicalis-a-house-dust-mite-in-the-tropics
#14
REVIEW
L Guilleminault, C Viala-Gastan
INTRODUCTION: Blomia tropicalis is a mite that belongs to the superfamily of Glycyphagidae. Initially described as a storage mite, it is now considered as a house dust mite of tropical and sub-tropical areas. STATE OF THE ART: Sensitization to this mite is very common in South America and Southeast Asia. Epidemiological studies have also found sensitization to this mite in Africa and Central America. Blo t 5 is the major allergen of B. tropicalis. Co-sensitization to other house dust mites such as Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) is very common...
May 12, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28502133/t-regulatory-cells-response-to-allergen-specific-immunotherapy-in-patients-with-allergic-airway-diseases-a-prospective-study
#15
Raghdaa A Ramadan, Emad A Morad, Mohamed El-Shabrawy
Forkhead box P3 (FoxP3) T regulatory (Treg) cells modulate the immune system by blocking other types of T-cells. They maintain tolerance to self-antigens and help in inducing tolerance to foreign antigens. A deregulation of FoxP3 Tregs seems to play an important role in allergic disorders. The aim of this work was to study the response of FoxP3 Treg cells and their FoxP3 expression in patients, attending the Allergy Unit and the Chest Outpatient Clinic, Faculty of Medicine, Zagazig University, with allergic airway diseases, before and 1 year after receiving subcutaneous allergen specific immunotherapy (SIT)...
June 2016: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/28501976/component-resolved-diagnosis-in-hymenoptera-anaphylaxis
#16
REVIEW
D Tomsitz, K Brockow
PURPOSE OF REVIEW: Hymenoptera anaphylaxis is one of the leading causes of severe allergic reactions and can be fatal. Venom-specific immunotherapy (VIT) can prevent a life-threatening reaction; however, confirmation of an allergy to a Hymenoptera venom is a prerequisite before starting such a treatment. Component resolved diagnostics (CRD) have helped to better identify the responsible allergen. RECENT FINDINGS: Many new insect venom allergens have been identified within the last few years...
June 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28501765/enhanced-sublingual-immunotherapy-by-tat-fused-recombinant-allergen-in-a-murine-rhinitis-model
#17
Farhad Salari, Fatemeh Vahedi, Abdol-Reza Varasteh, Hanieh Ketabdar, Jamshidkhan Chamani, Mojtaba Sankian
Allergen-specific sublingual immunotherapy (SLIT) is well known as an effective and non-invasive route to induce allergy desensitization. The goal of this study was to investigate whether a TAT-fused recombinant allergen could enhance SLIT efficacy. BALB/c mice sensitized to the main allergen (Che a 3) of Chenopodium album pollen were treated sublingually either with rChe a 3 (100μg/dose) or rTAT-Che a 3 (100μg/dose), two times per week for eight weeks. SLIT with rTAT-Che a 3 led to significantly greater allergen-specific IgG2a than rChe a 3; however, neither rTAT-Che a 3 nor rChe a 3 affected allergen-specific IgE or IgG1 antibody levels...
May 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28497677/successful-of-subcutaneous-and-oral-hyposensitizing-therapy-in-30-patients
#18
A Tammaro, I Romano, F R Parisella, G De Marco, F Persechino, I Trimarchi, S Persechino
Background. Pharmacotherapy and immunotherapy are the main treatment modalities for respiratory allergy. The aim of this paper has been to evaluate the efficacy and tolerability of subcutaneous and sublingual immunotherapy in association in allergic patients, and to demonstrate that the patients who have performed a second oral vaccination cycle after 4-5 years from the first subcutaneous treatment, derive benefits that may last for years. This is due to immune system's plasticity. Methods. The study was conducted in 30 allergic patients which had previously executed a full cycle of classical subcutaneous immunotherapy, with a partial remission of symptoms...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497671/perceived-efficacy-and-satisfaction-of-patients-with-subcutaneous-hypoallergenic-high-dose-house-dust-mite-extract
#19
A Roger Reig, M Ibero Iborra, T Carrillo Díaz, R López Abad, V Sánchez Moreno, J Álvarez Nieto, N Cancelliere
The efficacy and safety of subcutaneous immunotherapy with modified, high-dose, major allergen house dust mite extract is widely supported by double-blind, placebo-controlled studies. However, little is known regarding patient-perceived efficacy and satisfaction. An observational, retrospective, multicentre study in patients treated with Acaroid(®) was conducted to assess the efficacy and degree of satisfaction of the patients after the first six months of treatment with it. All the clinical study procedures were performed according to the routine clinical practice...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497578/effector-and-regulatory-dendritic-cells-display-distinct-patterns-of-mirna-expression
#20
Vincent Lombardi, Sonia Luce, Hélène Moussu, Lise Morizur, Claire Gueguen, Catherine Neukirch, Sylvie Chollet-Martin, Laurent Mascarell, Michel Aubier, Véronique Baron-Bodo, Philippe Moingeon
INTRODUCTION: MicroRNAs (miRNAs) contribute to the regulation of dendritic cell (DC) polarization, thereby influencing the balance of adaptive immune responses. Herein, we studied the expression of miRNAs in polarized DCs and analyzed whether expression of these miRNAs could be associated with allergic rhinitis and allergen immunotherapy (AIT) outcome. METHOD: Using specific culture conditions, we differentiated immature human monocyte-derived DCs into DC1, DC2, and DCreg subsets (supporting the differentiation of TH 1, TH 2 or regulatory T cells, respectively)...
May 12, 2017: Immunity, Inflammation and Disease
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