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Allergen immunotherapy

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https://www.readbyqxmd.com/read/29024520/allergen-immunotherapy-exploring-areas-for-further-inquiry
#1
Tam Ramsey, Wanda Lai, Peter F Svider, Houmehr Hojjat, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: Allergy-related illness impacts millions of individuals worldwide. Our objectives were to characterize current trends of clinical trials research relating to allergen immunotherapy and to describe the landscape of allergen immunotherapy in National Institutes of Health (NIH)-supported research inquiry. METHODS: On ClinicalTrials.gov, the following terms were searched: allergen immunotherapy OR allergy immunotherapy. Variables, including completion status, dates, design, study population, funder, location, and allergen were recorded...
October 12, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29021893/the-efficacy-of-oral-and-subcutaneous-antigen-specific-immunotherapy-in-murine-cow-s-milk-and-peanut-allergy-models
#2
Marlotte M Vonk, Laura Wagenaar, Raymond H H Pieters, Leon M J Knippels, Linette E M Willemsen, Joost J Smit, Betty C A M van Esch, Johan Garssen
BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in murine models for CMA and PNA and determine the dose of allergen needed to effectively modify parameters of allergy. METHODS: Female C3H/HeOuJ mice were sensitized intragastrically (i...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28992950/future-horizons-in-allergy
#3
REVIEW
Michael J Marino, Amber U Luong
There are several advances in diagnosis and management for the otolaryngologist treating allergy. These include new technologies and the refinement of current techniques, and reflect overall trends in health care toward personalized medicine. Local immunoglobulin, urinary leukotriene E4, lipidomics, microRNA within extracellular vesicles, and optical rhinometry all offer to improve the diagnostic accuracy of allergy and related nonallergic conditions. New delivery systems for intranasal steroids and antihistamines, recombinant allergens, advances in allergen immunotherapy delivery, and biologics will improve current management options...
October 6, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28983485/anti-ige-treatment-for-disorders-other-than-asthma
#4
REVIEW
Jeffrey Stokes
Immunoglobulin E (IgE) plays a key role in the pathogenesis of many allergic diseases. Thus, IgE-mediated immunologic pathways are an attractive target for intervention in allergic diseases. Omalizumab is a recombinant humanized monoclonal antibody that binds IgE and has been used treat allergic asthma for over a decade. Currently, omalizumab is approved for the treatment of both allergic asthma and chronic spontaneous urticaria. Since IgE plays a critical role in other allergic diseases, anti-IgE therapy has been evaluated in other allergic diseases in small clinical trials and case reports...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28979688/the-role-of-il-25-in-the-reduction-of-oxidative-stress-and-the-apoptosis-of-airway-epithelial-cells-with-specific-immunotherapy-in-an-asthma-mouse-model
#5
Xiefang Yuan, Eryi Wang, Xiaojun Xiao, Junyi Wang, Xiaomeng Yang, Pingchang Yang, Guoping Li, Zhigang Liu
Oxidative stress and cell apoptosis play important roles in the pathogenesis of asthma. Specific immunotherapy (SIT) is the only curative approach for asthma and is effective at decreasing asthmatic oxidation and cell apoptosis, but the mechanisms remain unclear. In this study, by using in vivo and in vitro models, we indirectly demonstrated that SIT alleviated the apoptosis and oxidative stress of bronchial epithelial cells in an asthma model through regulating interleukin (IL)-25. Female BALB/c mice were used for an asthma model induced by exposure to house dust mite (HDM) extracts as allergens...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28978148/allergen-specific-immunotherapy-enhanced-defense-against-bacteria-via-tgf-%C3%AE-1-induced-cyp27b1-in-asthma
#6
Junyi Wang, Xiaoyu Liu, Hui Wang, Yin Li, Nan Lan, Xiefang Yuan, Min Wu, Zhigang Liu, Guoping Li
Allergen specific immunotherapy (SIT) is the only specific treatment of allergic diseases at present. How SIT impacts pulmonary innate immunity against bacteria currently remains unclear. In this study, dust mite extracts (HDM)-sensitized mice were immunized with a subcutaneous injection of HDM. These mice were then challenged with an intranasal administration of HDM. After the last challenge, mice were infected with an intranasal instillation with P. aeruginosa (P.a). We measured the score of tissue inflammation, the expression of cathelicidin-related antimicrobial peptide (CRAMP) and 25-Hydroxyvitamin D-1Alpha-hydroxylase (CYP27B1) in lung...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28968272/preventing-new-sensitization-and-asthma-onset-by-allergen-immunotherapy-the-current-evidence
#7
Ulrich Wahn
PURPOSE OF REVIEW: Specific allergen immunotherapy is considered a key candidate for a successful preventive intervention in atopic diseases. The strong association of atopic manifestations such as rhinitis and asthma with atopic sensitizations (specific serum IgE) provide a rationale for early intervention in childhood and adolescence. RECENT FINDINGS: Currently, the documentation of the disease-modifying intervention effects is limited to the secondary prevention of asthma symptoms in children with allergic rhinoconjunctivitis...
September 28, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28965967/evaluation-of-nanoparticles-as-oral-vehicles-for-immunotherapy-against-experimental-peanut-allergy
#8
Ana Brotons-Canto, Carlos Gamazo, Nekane Martín-Arbella, Muthanna Abdulkarim, Jose Matías, Mark Gumbleton, Juan M Irache
The aim of this work was to evaluate the potential application of an original oral immunotherapy, based on the use of nanoparticles, against an experimentally induced peanut allergy. In this context, a roasted peanut extract, containing the main allergenic proteins, were encapsulated into poly(anhydride) nanoparticles. The resulting devices (PE-NP) displayed a mean size of about 150nm and a significantly lower surface hydrophobicity than empty nanoparticles (NP). This low hydrophobicity correlated well with a higher in vitro diffusion in pig intestinal mucus than NP and an important in vivo capability to reach the intestinal epithelium and Peyer's patches...
September 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28964530/efficacy-and-safety-of-subcutaneous-and-sublingual-immunotherapy-for-allergic-rhinoconjunctivitis-and-asthma
#9
REVIEW
Christopher R Roxbury, Sandra Y Lin
Allergic rhinitis is often associated with asthma and has significant impacts on health care costs and productivity in the United States. Although allergen avoidance and pharmacotherapy are effective, allergen-specific immunotherapy is the only treatment that may lead to improved allergy symptoms even after treatment is discontinued. Subcutaneous immunotherapy has been the mainstay of allergen-specific immunotherapy in the United States for decades, but sublingual immunotherapy has recently become available...
September 27, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28964528/immunotherapy-treating-with-fewer-allergens
#10
REVIEW
Cecelia Damask
Polysensitization, sensitization to more than one allergen, is a common feature of patients with allergic rhinitis, and may be a risk factor for subsequent development of allergic diseases, especially allergic asthma. However, a polysensitized patient does not necessarily have polyallergy, a documented, causal relationship between exposure to 2 or more specific, sensitizing allergens and the subsequent occurrence of relevant clinical symptoms of allergy. Allergen immunotherapy treatment strategy for the polysensitized patient in Europe is to treat the single or 2 most clinically relevant allergen(s), whereas patients in the United States are usually treated for all potential clinically relevant allergens...
September 27, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28960180/salsola-kali-cross-reacts-extensively-with-salsola-imbricata
#11
M Al-Ahmad, T Rodriguez-Bouza, N Fakim, F Pineda
BACKGROUND: There are no studies on the cross-reactivity between Salsola kali and Salsola imbricata pollens. The main goal is to compare the degree of the cross-reactivity between Salsola kali and Salsola imbricata, and secondly to compare the various common allergen components between Salsola kali and Salsola imbricata. METHODS: Serum from rhinitis patients with or without asthma living in Kuwait presenting with a positive skin test to Salsola kali were obtained...
September 29, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28957824/the-role-of-regulatory-b-cells-in-allergen-immunotherapy
#12
Willem van de Veen
PURPOSE OF REVIEW: Allergen immunotherapy (AIT) is currently the only curative treatment available for allergic diseases, and has been used in clinical practice for over a century. Induction and maintenance of immune tolerance to nonhazardous environmental and self-antigens is essential to maintain homeostasis and prevent chronic inflammation. Regulatory B (BREG) cells are immunoregulatory cells that protect against chronic inflammatory responses primarily through production of anti-inflammatory cytokines such as IL-10, transforming growth factor-β, and IL-35...
September 27, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28950271/bioavailability-of-house-dust-mite-allergens-in-sublingual-allergy-tablets-is-highly-dependent-on-the-formulation
#13
Katsuyo Ohashi-Doi, Hirokazu Kito, Weibin Du, Hiroshi Nakazawa, Henrik Ipsen, Pernille Gudmann, Kaare Lund
BACKGROUND: In sublingual immunotherapy (SLIT), the immune system is addressed by solubilized allergen that interacts with immunocompetent cells of the oral mucosa, the efficiency of which is governed by 2 main factors of SLIT allergen bioavailability: the allergen concentration and the mucosal contact time. Recently, 3 house dust mite (HDM) SLIT tablets were developed that differ with regard to allergen content, nominal strength (maintenance doses: 6 SQ-HDM/10,000 Japanese Allergen Units [JAU], 12 SQ-HDM/ 20,000 JAU, and 300 IR/57,000 JAU), and formulation (freeze-dried/compressed)...
September 27, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28941667/advances-and-highlights-in-allergen-immunotherapy-on-the-way-to-sustained-clinical-and-immunologic-tolerance
#14
Margot Berings, Cagatay Karaaslan, Can Altunbulakli, Philippe Gevaert, Mübeccel Akdis, Claus Bachert, Cezmi A Akdis
Allergen immunotherapy (AIT) is an effective treatment strategy for allergic diseases and has been used for more than 100 years. In recent years, however, the expectations on concepts, conduct, statistical evaluation and reporting have been significantly developed. Products have undergone dose-response and confirmative studies in adults and children to provide evidence for the optimal dosage, safety and efficacy of AIT vaccines using subcutaneous and sublingual delivery pathways in large patient cohorts, ensuring solid conclusions to be drawn from them for the advantage of patients and societies alike...
September 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28940458/eaaci-guidelines-on-allergen-immunotherapy-allergic-rhinoconjunctivitis
#15
G Roberts, O Pfaar, C A Akdis, I J Ansotegui, S R Durham, R Gerth van Wijk, S Halken, D Larenas-Linnemann, R Pawankar, C Pitsios, A Sheikh, M Worm, S Arasi, M A Calderon, C Cingi, S Dhami, J L Fauquert, E Hamelmann, P Hellings, L Jacobsen, E F Knol, S Y Lin, P Maggina, R Mösges, H Oude Elberin, G B Pajno, E A Pastorello, M Penagos, G Rotiroti, C B Schmidt-Weber, F Timmermans, O Tsilochristou, E M Varga, J N Wilkinson, A Williams, L Zhang, I Agache, E Angier, M Fernandez-Rivas, M Jutel, S Lau, R van Ree, D Ryan, G Sturm, A Muraro
Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmacotherapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side-effects. Allergen immunotherapy (AIT) represents the only currently available treatment that targets the underlying pathophysiology and it may have a disease modifying effect...
September 23, 2017: Allergy
https://www.readbyqxmd.com/read/28940450/national-clinical-practice-guidelines-for-allergen-immunotherapy-an-international-assessment-applying-agree-ii
#16
D E S Larenas-Linnemann, D Antolín-Amérigo, C Parisi, A Nakonechna, J A Luna-Pech, B Wedi, I Davila, M Gómez, M Levin, J A Ortega-Martell, L Klimek, N Rosario, A M Muraro, I Agache, J Bousquet, A Sheikh, O Pfaar
BACKGROUND: Since 1988 numerous allergen immunotherapy guidelines (AIT-GLs) have been developed by national and international organizations to guide physicians in AIT. Even so, AIT is still severely under-used. OBJECTIVE: to evaluate AIT-GLs with AGREE-II, developed in 2010 by McMaster University methodologists to comprehensively evaluate GL-quality. METHODS: Allergist, from different continents, knowledgeable in AIT and AGREE-II trained were selected into the project team...
September 21, 2017: Allergy
https://www.readbyqxmd.com/read/28934008/decorating-and-loading-ghosts-with-allergens-for-allergen-immunotherapy
#17
Songwe Fanuel, Saeideh Tabesh, Huda Fatima Rajani, Sahel Heidari, Esmaeil Sadroddiny, Gholam Ali Kardar
More than 25% of the global population suffers from IgE mediated allergic diseases. Allergen immunotherapy (AIT) is the only available form of treatment that alters the underlying mechanism of IgE-mediated allergic diseases. AIT is aimed at desensitizing allergic individuals by repeatedly administering disease-causing allergens over a long period of time. Despite its proven efficacy in numerous clinical trials, the effectiveness of AIT still suffers some drawbacks due to the quality of allergens used and in particular the unavailability of efficient allergen delivery systems...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933669/broad-perspectives-of-allergen-specific-immunotherapy
#18
Wayne Robert Thomas
No abstract text is available yet for this article.
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933051/erratum-to-human-immune-monitoring-techniques-during-food-allergen-immunotherapy
#19
Blake J Rust, Erik Wambre
No abstract text is available yet for this article.
October 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28932386/erratum-to-allergen-immunotherapy-for-allergic-asthma-protocol-for-a-systematic-review
#20
Sangeeta Dhami, Ulugbek Nurmatov, Ioana Agache, Susanne Lau, Antonella Muraro, Marek Jutel, Graham Roberts, Cezmi Akdis, Matteo Bonini, Moises Calderon, Thomas Casale, Ozlem Cavkaytar, Linda Cox, Pascal Demoly, Breda Flood, Eckard Hamelmann, Kenji Izuhara, Ömer Kalayci, Jörg Kleine-Tebbe, Antonio Nieto, Nikolaos Papadopoulos, Oliver Pfaar, Lanny Rosenwasser, Dermot Ryan, Carsten Schmidt-Weber, Stan Szefler, Ulrich Wahn, Roy-Gerth van Wijk, Jamie Wilkinson, Aziz Sheikh
[This corrects the article DOI: 10.1186/s13601-016-0094-y.].
2017: Clinical and Translational Allergy
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