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Cristina Mumbardó-Adam, Joan Guàrdia-Olmos, Ana L Adam-Alcocer, Maria Carbó-Carreté, Anna Balcells-Balcells, Climent Giné, Karrie A Shogren
The relation between self-determination and intellectual functioning is complex, as other contextual factors may also play significant roles in explaining variability in self-determination. This study used meta-analytic techniques to assess how self-determination measures vary between people with disabilities classified as having intellectual disability (ID) or not, and contextual variables that moderate this relation. The literature search yielded 16 eligible studies, whose variables of interest were coded and analyzed...
October 2017: Intellectual and Developmental Disabilities
Heather Tolle, Andrew Rapacz, Barry Weintraub, Carrie Shogren, Susan J Harkema, Jeremy L Gibson
BACKGROUND: Physical fitness is a necessity for those living with a spinal cord injury, yet access to fitness facilities, equipment, and specially trained fitness experts are limited. METHODS: This article introduces the concept of a network of fitness facilities specially geared towards individuals with spinal cord injury and other neurological disorders. RESULTS: The Community Fitness and Wellness branch of the NeuroRecovery Network was created to provide a continuum of care after traditional rehabilitation for individuals living with a spinal cord injury and other neurological disorders...
August 17, 2017: Disability and Rehabilitation
Karrie A Shogren, Ruth Luckasson, Robert L Schalock
This article provides a framework for an integrated approach to disability policy development, implementation, and evaluation. The article discusses how a framework that combines systems thinking and valued outcomes can be used by coalition partners across ecological systems to implement disability policy, promote the effective use of resources, incorporate specific support strategies that advance identified disability policy goals and lead to systemic changes and enhanced personal outcomes, and focus on activities that advance a unified vision for disability policy and the attainment of personal outcomes...
July 2017: Intellectual and Developmental Disabilities
Arial J Shogren, Jennifer L Tank, Elizabeth Andruszkiewicz, Brett Olds, Andrew R Mahon, Christopher L Jerde, Diogo Bolster
Advances in detection of genetic material from species in aquatic ecosystems, including environmental DNA (eDNA), have improved species monitoring and management. eDNA from target species can readily move in streams and rivers and the goal is to measure it, and with that infer where and how abundant species are, adding great value to delimiting species invasions, monitoring and protecting rare species, and estimating biodiversity. To date, we lack an integrated framework that identifies environmental factors that control eDNA movement in realistic, complex, and heterogeneous flowing waters...
July 11, 2017: Scientific Reports
Carl T Gustafson, Tewodros Mamo, Kristen L Shogren, Avudaiappan Maran, Michael J Yaszemski
Osteosarcoma (OS) is an aggressive primary bone tumor which exhibits aberrantly activated Wnt signaling. The canonical Wnt signaling cascade has been shown to drive cancer progression and metastasis through the activation of β-catenin. Hence, small molecule inhibitors of Wnt targets are being explored as primary or adjuvant chemotherapy. In this study, we have investigated the ability of FH535, an antagonist of Wnt signaling, to inhibit the growth of OS cells. We found that FH535 was cytotoxic in all OS cell lines which were tested (143b, U2OS, SaOS-2, HOS, K7M2) but well tolerated by normal human osteoblast cells...
2017: Frontiers in Pharmacology
Melissa J Blacketer, Margaret K Gannon, Isaac A Young, Michael A Shogren-Knaak
DNA templates for assembling chromatin model systems typically consist of numerous repeats of nucleosome positioning sequences, making their synthesis challenging. Here we describe a solid-phase strategy for generating such templates using sequential enzymatic ligation of DNA monomers. Using single nucleosome site monomers, we can either generate a twelve-nucleosome site target, or systematically access intermediate-sized templates. Using twelve nucleosome positioning site monomers, longer templates can be generated...
August 15, 2017: Analytical Biochemistry
Natalie A Griffiths, Jennifer L Tank, Todd V Royer, Emma J Rosi, Arial J Shogren, Therese C Frauendorf, Matt R Whiles
The insecticidal Cry1Ab protein expressed by transgenic (Bt) maize can enter adjacent water bodies via multiple pathways, but its fate in stream ecosystems is not as well studied as in terrestrial systems. In this study, we used a combination of field sampling and laboratory experiments to examine the occurrence, leaching, and degradation of soluble Cry1Ab protein derived from Bt maize in agricultural streams. We surveyed 11 agricultural streams in northwestern Indiana, USA, on 6 dates that encompassed the growing season, crop harvest, and snowmelt/spring flooding, and detected Cry1Ab protein in the water column and in flowing subsurface tile drains at concentrations of 3-60ng/L...
March 14, 2017: Science of the Total Environment
Tewodros Mamo, Ann C Mladek, Kris L Shogren, Carl Gustafson, Shiv K Gupta, Scott M Riester, Avudaiappan Maran, Mario Galindo, Andre J van Wijnen, Jann N Sarkaria, Michael J Yaszemski
Osteosarcoma survival rate has not improved over the past three decades, and the debilitating side effects of the surgical treatment suggest the need for alternative local control approaches. Radiotherapy is largely ineffective in osteosarcoma, indicating a potential role for radiosensitizers. Blocking DNA repair, particularly by inhibiting the catalytic subunit of DNA-dependent protein kinase (DNA-PKCS), is an attractive option for the radiosensitization of osteosarcoma. In this study, the expression of DNA-PKCS in osteosarcoma tissue specimens and cell lines was examined...
April 29, 2017: Biochemical and Biophysical Research Communications
Hyojeong Seo, Karrie A Shogren, Michael L Wehmeyer, Todd D Little, Susan B Palmer
As adolescents with intellectual disability (ID) transition to adulthood, there is a need to plan for effective community-based supports that address the post-school life. There is also a need to plan for the impact of factors (e.g., medical/behavioral support needs) on supports needed for community participation. Data from the Supports Intensity Scale-Adult Version (SIS-A) was used to examine relations between medical/behavior support needs and support needs assessed in the standardized portion of the SIS-A...
March 2017: American Journal on Intellectual and Developmental Disabilities
Karrie A Shogren, Leslie A Shaw, Michael L Wehmeyer, James R Thompson, Kyle M Lang, Marc J Tassé, Robert L Schalock
The Supports Intensity Scale-Children's version (SIS-C) was developed to provide a standardized measure of support needs of children with intellectual disability. Over half of the norming sample had a secondary diagnosis of autism. Using this subset of the sample, we engaged in exploratory analysis to examine the degree to which latent clusters were present in the data, and after identifying these clusters, the degree to which they mapped on the SIS-C standard scores. A four latent class solution provided the best fit to the data...
January 9, 2017: Journal of Autism and Developmental Disorders
Evan E Dean, Kim W Fisher, Karrie A Shogren, Michael L Wehmeyer
Participation is a central aspect of human functioning and a key focus of research and practice in the intellectual disability field. However, there is not an accepted definition of participation that guides research and practice. To inform the development of a definition, a scoping review of the intellectual disability literature from 2001-2015 was conducted. Findings suggest that existing research rarely uses definitions of participation, but does examine participation across multiple domains and addresses issues of access and inclusion...
December 2016: Intellectual and Developmental Disabilities
Dalibel Bravo, Kristen L Shogren, Dongqing Zuo, Eric R Wagner, Gobinda Sarkar, Michael J Yaszemski, Avudaiappan Maran
Osteosarcoma is a bone tumor that mainly affects children and adolescents. Although its pathogenesis is still not fully understood, activation of Wnt signaling has been implicated in the development and metastasis of osteosarcoma. In this report, we have investigated the effect of the anti-tumor compound, 2-methoxyestradiol (2-ME) on Wnt antagonist frizzled-related protein b (Frzb), also known as secreted frizzled-related protein (sFRP)3 in human osteosarcoma (MG63) cells. Our results show that 2-ME treatment induces Frzb gene promoter activity, and increases Frzb mRNA and protein levels in osteosarcoma cells...
June 2017: Journal of Cellular Biochemistry
Stephen T Jackson, Clifford S Duke, Stephanie E Hampton, Katharine L Jacobs, Lucas N Joppa, Karim-Aly S Kassam, Harold A Mooney, Laura A Ogden, Mary Ruckelshaus, Jason F Shogren
No abstract text is available yet for this article.
November 18, 2016: Science
Hyojeong Seo, Karrie A Shogren, Todd D Little, James R Thompson, Michael L Wehmeyer
This study examined the convergent validity of the Supports Intensity Scale - Adult Version (SIS-A; Thompson et al., 2015a ) and Supports Intensity Scale - Children's Version (SIS-C; Thompson et al., 2016a ). Data from SISOnline (n = 129,864) for the SIS-A and from the SIS-C standardization sample (n = 4,015) were used for analyses. Using a pseudo multitrait-multimethod model, we estimated observed support needs scores as shared trait (support needs concept) and method (type, frequency, and daily support time) variances...
November 2016: American Journal on Intellectual and Developmental Disabilities
Christopher L Jerde, Brett P Olds, Arial J Shogren, Elizabeth A Andruszkiewicz, Andrew R Mahon, Diogo Bolster, Jennifer L Tank
While environmental DNA (eDNA) is now being regularly used to detect rare and elusive species, detection in lotic environments comes with a caveat: The species being detected is likely some distance upstream from the point of sampling. Here, we conduct a series of seminatural stream experiments to test the sensitivity of new digital droplet PCR (ddPCR) to detect low concentrations of eDNA in a lotic system, measure the residence time of eDNA compared to a conservative tracer, and we model the transport of eDNA in this system...
August 16, 2016: Environmental Science & Technology
Anthony J Plotner, Karrie A Shogren, Leslie A Shaw, Chelsea VanHorn Stinnett, Hyojeong Seo
INTRODUCTION: Research involving secondary transition practices indicates a growing implementation of interagency collaboration to maximize service delivery to support students transitioning from school to adult life. Centers for Independent Living (CILs) are often excluded from collaborative partnerships and denied the opportunity to contribute as a valued stakeholder in the transition process. METHOD: A total of 189 CIL professionals representing represented 38 states completed the online survey to (a) identify to what degree does the factor structure of Thompson's Collaboration Survey holds for CIL professionals and (b) explore what specific CIL professional and agency characteristics predict greater collaboration between CILs and local education agencies (LEAs)...
June 25, 2016: Disability and Rehabilitation
James R Thompson, Karrie A Shogren, Hyojeong Seo, Michael L Wehmeyer, Kyle M Lang
The Supports Intensity Scale - Adult Version (SIS-A) has been widely adopted throughout North America and the world since its publication a little over a decade ago. Many organizations and jurisdictions operate under regulations that require an annual assessment of people who receive services and supports that are financed through public funds. The time and energy devoted to an annual SIS-A reassessment has become a concern in cases where the resulting information is largely redundant with information from a prior assessment...
June 2016: Intellectual and Developmental Disabilities
Arial J Shogren, Jennifer L Tank, Elizabeth A Andruszkiewicz, Brett Olds, Christopher Jerde, Diogo Bolster
Detecting environmental DNA (eDNA) in water samples is a powerful tool in determining the presence of rare aquatic species. However, many open questions remain as to how biological and physical conditions in flowing waters influence eDNA. Motivated by what one might find in a stream/river benthos we conducted experiments in continuous flow columns packed with porous substrates to explore eDNA transport and ask whether substrate type and the presence of colonized biofilms plays an important role for eDNA retention...
June 2016: Journal of the Royal Society, Interface
Susan J Harkema, Carrie Shogren, Elizabeth Ardolino, Douglas J Lorenz
The Neuromuscular Recovery Scale (NRS) is a tool for measuring functional recovery in spinal cord injured (SCI) persons based on tasks that test pre-injury functional capability. The NRS has been shown to be a valid, reliable, and responsive instrument for measuring functional recovery. The NRS has been updated to include three items measuring upper extremity function, and a new scoring mechanism has been defined. The purpose of this prospective, observational study was to explore the properties of the expanded NRS, introduce and evaluate the new scoring method, and to examine the score's relationship with other SCI outcome measures...
December 15, 2016: Journal of Neurotrauma
Suzanne E U Kerns, Michael D Pullmann, Andrea Negrete, Jacqueline A Uomoto, Lucy Berliner, Dae Shogren, Ellen Silverman, Barbara Putnam
Effective strategies that increase the extent to which child welfare professionals engage in trauma-informed case planning are needed. This study evaluated two approaches to increase trauma symptom identification and use of screening results to inform case planning. The first study evaluated the impact of training on trauma-informed screening tools for 44 child welfare professionals who screen all children upon placement into foster care. The second study evaluated a two-stage approach to training child welfare workers on case planning for children's mental health...
May 2016: Child Maltreatment
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