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Low vitamin d and alopecia

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https://www.readbyqxmd.com/read/27605903/the-role-of-serum-vitamin-d-levels-in-vitiligo
#1
Ebru Karagün, Can Ergin, Sevim Baysak, Gönül Erden, Habibullah Aktaş, Özlem Ekiz
INTRODUCTION: Vitiligo is a common acquired pigmentary skin disorder. Vitamin D is responsible for skin pigmentation, increases tyrosinase activity and melanogenesis, and exhibits immunoregulatory functions. Low levels of vitamin D are associated with many autoimmune diseases, including systemic lupus, diabetes mellitus, rheumatoid arthritis, multiple sclerosis and alopecia areata. Few reports have evaluated serum vitamin D levels in vitiligo patients, and their results are conflicting...
August 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27601857/female-pattern-hair-loss-a-retrospective-study-in-a-tertiary-referral-center
#2
Tee Wei Siah, Llorenia Muir-Green, Jerry Shapiro
BACKGROUND: Female pattern hair loss (FPHL) is a very common problem in women. The underlying pathophysiology remains unclear, and there are no universally agreed treatment guidelines. OBJECTIVE: We explored the clinical features, relevant medical and family history, laboratory evaluation, and treatment and compliance of 210 patients with FPHL. METHODS: Data analysis from case notes was performed on 210 patients with a diagnosis of FPHL seen from January 2011 to December 2011...
April 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/27408766/clinical-and-genetic-findings-in-a-chinese-family-with-vdr-associated-hereditary-vitamin-d-resistant-rickets
#3
Qianqian Pang, Xuan Qi, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Jin Dong, Weibo Xia
Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disorder characterized by severe rickets, hypocalcemia, hypophosphatemia, secondary hyperparathyroidism, and elevated alkaline phosphatase. This disorder is caused by homogeneous or heterogeneous mutations affecting the function of the vitamin D receptor (VDR), which lead to complete or partial target organ resistance to the action of 1,25-dihydroxy vitamin D. A non-consanguineous family of Chinese Han origin with one affected individual demonstrating HVDRR was recruited, with the proband evaluated clinically, biochemically and radiographically...
2016: Bone Research
https://www.readbyqxmd.com/read/26994969/the-transient-role-for-calcium-and-vitamin%C3%A2-d-during-the-developmental-hair%C3%A2-follicle-cycle
#4
Leila J Mady, Dare V Ajibade, Connie Hsaio, Arnaud Teichert, Chak Fong, Yongmei Wang, Sylvia Christakos, Daniel D Bikle
The role for 1,25-dihydroxyvitamin D3 and/or calcium in hair follicle cycling is not clear despite their impact on keratinocyte differentiation. We found that calbindin-D9k null (knockout) pups generated from calbindin-D9k knockout females fed a vitamin D-deficient, low-calcium (0.47%) diet develop transient alopecia. The pups appear phenotypically normal until 13 days of age, after which the hair progressively sheds in a caudocephalic direction, resulting in truncal alopecia totalis by 20-23 days, with spontaneous recovery by 28 days...
July 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/26599618/the-effect-of-dietary-modulation-of-sulfur-amino-acids-on-cystathionine-%C3%AE-synthase-deficient-mice
#5
REVIEW
Warren D Kruger, Sapna Gupta
Cystathionine β synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine. Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine. The treatment goal for CBS-deficient patients is to normalize the metabolic values of these three metabolites using a combination of vitamin therapy and dietary manipulation...
January 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/26551946/current-treatments-for-alopecia-areata
#6
REVIEW
Maria K Hordinsky
Selection of a therapy for a patient with alopecia areata (AA) is frequently based on the age of the patient, disease extent, perhaps disease duration, patient expectations, cost of therapy in terms of time commitment, and financial resources, as well as the results of screening laboratory studies that rule out the presence of other co-morbidities such as anemia, low iron stores, thyroid abnormalities, low vitamin D, or other autoimmune diseases. Although there is currently no cure for AA and no universally proven therapy that induces and sustains remission, many therapies are available which can be of benefit to both affected children and adults...
November 2015: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/26091388/topical-calcipotriol-therapy-for-mild-to-moderate-alopecia-areata-a-retrospective-study
#7
Aslı Aksu Çerman, Sezgi Sarıkaya Solak, İlknur Altunay, Nihal Aslı Küçükünal
BACKGROUND: Alopecia areata (AA) is considered a T-cell mediated autoimmune disease characterized by patchy loss of hair from scalp and other body parts with no definitive treatment. Calcipotriol is a vitamin D analogue and a potent immunomodulatuary molecule. In recent studies, low serum vitamin D levels have been observed in patients with AA and various autoimmune diseases. Previous reports have also described the effects of vitamin D on hair follicles. OBJECTIVE: The aim of the study was to evaluate the efficacy and safety of topical calcipotriol for the treatment of mild-to-moderate patchy AA...
June 2015: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/24757409/vitamin-d-dependent-rickets-type-ii-case-report
#8
Mehmedali Azemi, Majlinda Berisha, Vlora Ismaili-Jaha, Selim Kolgeci, Rina Hoxha, Violeta Grajçevci-Uka, Teuta Hoxha-Kamberi
AIM: The aim of this work the report of one case with vitamin D-dependent rickets, type II. METHODS: Diagnosis has been established based on anamnesis, physical examination, laboratory findings and radiological examination. RESULTS: A female child (age 25 months) has been hospitalized due to bone deformity, bone pain, alopecia and walking difficulties. The laboratory findings have revealed that the calcium values was low (1.20 mmol/L), phosphates in the reference value (1...
February 2014: Materia Socio-medica
https://www.readbyqxmd.com/read/24107643/comorbidities-associated-with-vitiligo-a-ten-year-retrospective-study
#9
Vaneeta M Sheth, Ye Guo, Abrar A Qureshi
BACKGROUND: Vitiligo is a common disorder of depigmentation that has been associated with other autoimmune diseases. No recent large-scale data exist on the rates of comorbidities associated with vitiligo from the United States population. OBJECTIVES: To identify the prevalence of comorbidities as well as associated laboratory abnormalities in vitiligo patients. METHODS: All medical records dating from January 1, 2000 to June 21, 2011 within the Research Patient Data Repository were evaluated retrospectively using a novel artificial intelligence-based computer program...
2013: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/24002495/randomized-double-blind-placebo-controlled-phase-iii-chemoprevention-trial-of-selenium-supplementation-in-patients-with-resected-stage-i-non-small-cell-lung-cancer-ecog-5597
#10
RANDOMIZED CONTROLLED TRIAL
Daniel D Karp, Sandra J Lee, Steven M Keller, Gail Shaw Wright, Seena Aisner, Steven Alan Belinsky, David H Johnson, Michael R Johnston, Gary Goodman, Gerald Clamon, Gordon Okawara, Randolph Marks, Eric Frechette, Worta McCaskill-Stevens, Scott M Lippman, John Ruckdeschel, Fadlo R Khuri
PURPOSE: Selenium has been reported to have chemopreventive benefits in lung cancer. We conducted a double-blind, placebo-controlled trial to evaluate the incidence of second primary tumors (SPTs) in patients with resected non-small-cell lung cancer (NSCLC) receiving selenium supplementation. PATIENTS AND METHODS: Patients with completely resected stage I NSCLC were randomly assigned to take selenized yeast 200 μg versus placebo daily for 48 months. Participation was 6 to 36 months postoperatively and required a negative mediastinal node biopsy, no excessive vitamin intake, normal liver function, negative chest x-ray, and no other evidence of recurrence...
November 20, 2013: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/23428658/serum-ferritin-and-vitamin-d-in-female-hair-loss-do-they-play-a-role
#11
H Rasheed, D Mahgoub, R Hegazy, M El-Komy, R Abdel Hay, M A Hamid, E Hamdy
AIM: Evaluation of serum ferritin and vitamin D levels in females with chronic telogen effluvium (TE) or female pattern hair loss (FPHL), in order to validate their role in these common hair loss diseases. METHODS: Eighty females (18 to 45 years old) with hair loss, in the form of TE or FPHL, and 40 age-matched females with no hair loss were included in the study. Diagnosis was based upon clinical examination as well as trichogram and dermoscopy. Serum ferritin and vitamin D2 levels were determined for each participant...
2013: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/22877838/comparison-of-methotrexate-actinomycin-d-and-etoposide-for-treating-low-risk-gestational-trophoblastic-neoplasia
#12
COMPARATIVE STUDY
Angela M Baptista, Paulo Belfort
OBJECTIVE: To compare the efficacy and toxicity of 3 single agent chemotherapeutic regimens in low-risk gestational trophoblastic neoplasia (LRGTN). METHODS: A prospective study was conducted at a referral center in Rio de Janeiro, Brazil. Patients presenting with metastatic or non-metastatic LRGTN (risk score ≤ 6) in non-probabilistic sampling were assigned to 1 of 3 treatments: methotrexate with folinic acid rescue (MTX-CF; n=20); actinomycin D (n=20); and etoposide (n=20)...
October 2012: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/22251708/hypoparathyroidism-in-an-egyptian-child-with-hutchinson-gilford-progeria-syndrome-a-case-report
#13
Kotb Abbass Metwalley Kalil, Hekma Saad Fargalley
INTRODUCTION: Hutchinson-Gilford progeria syndrome is a rare genetic disorder. It is reported to be present in one in eight million and is characterized by severe growth failure, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, early atherosclerosis and facial features that resemble those of an aged person. Apart from diabetes mellitus, there are no reported abnormalities of thyroid, parathyroid, pituitary or adrenal function. Here, we report the case of a 10-year-old Egyptian child with Hutchinson-Gilford progeria syndrome and hypoparathyroidism...
2012: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/19574798/actinomycin-d-versus-methotrexate-folinic-acid-as-the-treatment-of-stage-i-low-risk-gestational-trophoblastic-neoplasia-a-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Arb-Aroon Lertkhachonsuk, Nathpong Israngura, Sarikapan Wilailak, Somsak Tangtrakul
This study is to compare the remission and complication rates of actinomycin D (Act-D) and methotrexate-folinic acid (MTX-FA) as single-agent treatments of stage I, low-risk gestational trophoblastic neoplasia (GTN). From 1994 to 2005, all women with International Federation of Gynecology and Obstetrics stage I, low-risk GTN were randomly assigned to received either intravenous Act-D 10 microg/kg per day for 5 days every 2 weeks or intramuscular methotrexate 1 mg/kg per day on days 1, 3, 5, and 7 with intramuscular folinic acid 0...
July 2009: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/17618180/diffuse-alopecia-in-a-child-due-to-dietary-zinc-deficiency
#15
Eyad Alhaj, Nehad Alhaj, Nezam E Alhaj
A 4-year-old girl was evaluated for hair loss of a few weeks' duration. History of the present illness, medical history, and review of systems were obtained from the parents, who described progressive diffuse hair loss with hair dryness and brittleness, with no change in the child's eating habits or any other unusual symptoms. No fever, weight loss, diarrhea, vomiting, abdominal pain, chronic cough, dyspnea, change in appetite, change in bowel habit, or urinary symptoms were noted. On further questioning, her nutritional history revealed that she always favored cow's milk in her diet...
July 2007: Skinmed
https://www.readbyqxmd.com/read/17129178/marked-disturbance-of-calcium-homeostasis-in-mice-with-targeted-disruption-of-the-trpv6-calcium-channel-gene
#16
Suzy D C Bianco, Ji-Bin Peng, Hitomi Takanaga, Yoshiro Suzuki, Alessandra Crescenzi, Claudine H Kos, Liyan Zhuang, Michael R Freeman, Cecilia H A Gouveia, Jiangping Wu, Hongyu Luo, Theodora Mauro, Edward M Brown, Matthias A Hediger
UNLABELLED: We report the phenotype of mice with targeted disruption of the Trpv6 (Trpv6 KO) epithelial calcium channel. The mice exhibit disordered Ca(2+) homeostasis, including defective intestinal Ca(2+) absorption, increased urinary Ca(2+) excretion, decreased BMD, deficient weight gain, and reduced fertility. Although our Trpv6 KO affects the closely adjacent EphB6 gene, the phenotype reported here is not related to EphB6 dysfunction. INTRODUCTION: The mechanisms underlying intestinal Ca(2+) absorption are crucial for overall Ca(2+) homeostasis, because diet is the only source of all new Ca(2+) in the body...
February 2007: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/15271069/white-monkey-syndrome-in-infant-baboons-papio-species
#17
COMPARATIVE STUDY
P A Frost, G B Hubbard, M J Dammann, C L Snider, C M Moore, V L Hodara, L D Giavedoni, R Rohwer, M C Mahaney, T M Butler, L B Cummins, T J McDonald, P W Nathanielsz, N E Schlabritz-Loutsevitch
Over 23 months, zinc toxicosis was diagnosed in 35 baboons aged 5-12 months in one galvanized metal and concrete cage complex with conditions that led to excessive exposure to environmental zinc. Clinical signs included reduced pigmentation of hair, skin, and mucous membranes (whiteness), alopecia, dehydration, emaciation, cachexia, dermatitis, diarrhea and, in six cases, severe gangrenous dermatitis of extremities. The syndrome was characterized by pancytopenia, elevated zinc and low copper serum concentrations, low vitamin D and bone-specific alkaline phosphatase levels, and atypical myelomonocytic proliferation of bone marrow...
August 2004: Journal of Medical Primatology
https://www.readbyqxmd.com/read/12403843/a-novel-mutation-in-helix-12-of-the-vitamin-d-receptor-impairs-coactivator-interaction-and-causes-hereditary-1-25-dihydroxyvitamin-d-resistant-rickets-without-alopecia
#18
Peter J Malloy, Rong Xu, Lihong Peng, Pamela A Clark, David Feldman
Hereditary vitamin D-resistant rickets (HVDRR) is a genetic disorder most often caused by mutations in the vitamin D receptor (VDR). The patient in this study exhibited the typical clinical features of HVDRR with early onset rickets, hypocalcemia, secondary hyperparathyroidism, and elevated serum concentrations of alkaline phosphatase and 1,25-dihydroxyvitamin D [1,25-(OH)(2)D(3)]. The patient did not have alopecia. Assays of the VDR showed a normal high affinity low capacity binding site for [(3)H]1,25-(OH)(2)D(3) in extracts from the patient's fibroblasts...
November 2002: Molecular Endocrinology
https://www.readbyqxmd.com/read/9495519/hereditary-1-25-dihydroxyvitamin-d-resistant-rickets-due-to-an-opal-mutation-causing-premature-termination-of-the-vitamin-d-receptor
#19
W Zhu, P J Malloy, E Delvin, G Chabot, D Feldman
Mutations in the vitamin D receptor (VDR) gene have been shown to cause hereditary vitamin D-resistant rickets (HVDRR). The patient in this study is a young French-Canadian boy with no known consanguinity in his family. The child exhibited the clinical characteristics of HVDRR with early onset rickets, hypocalcemia, secondary hyperparathyroidism, and elevated 1,25-dihydroxyvitamin D (1,25(OH)2D) levels as well as total alopecia. Fibroblasts were cultured from a skin biopsy of the patient and used to assess the VDR...
February 1998: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/9396138/histopathologic-and-ultrastructural-alterations-of-white-liver-disease-in-sheep-experimentally-depleted-of-cobalt
#20
S Kennedy, S McConnell, H Anderson, D G Kennedy, P B Young, W J Blanchflower
Many cobalt-deficient sheep develop liver lesions known as ovine "white liver" disease, but the etiology of these changes is controversial. It has been suggested that cofactors are required for development of liver damage in cobalt-deficient sheep. In this study, one group of lambs (n = 5) was fed a diet low in cobalt (4.5 micrograms/kg) while a group of control lambs (n = 4) received the same diet after it had been supplemented with cobalt (1000 micrograms/kg). All cobalt-depleted lambs had reduced growth rate, anorexia, lacrimation, and alopecia, and they eventually became emaciated (mean body weight at end of study: 83% of initial body weight)...
November 1997: Veterinary Pathology
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