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https://www.readbyqxmd.com/read/28643355/ultra-short-echo-time-images-quantify-high-liver-iron
#1
Eamon K Doyle, Kristin Toy, Bertin Valdez, Jonathan M Chia, Thomas Coates, John C Wood
PURPOSE: 1.5T gradient echo-based R2∗ estimates are standard-of-care for assessing liver iron concentration (LIC). Despite growing popularity of 3T, echo time (TE) limitations prevent 3T liver iron quantitation in the upper half of the clinical range (LIC ⪆20 mg/g). In this work, a 3D radial pulse sequence was assessed to double the dynamic range of 3T LIC estimates. THEORY AND METHODS: The minimum TE limits the dynamic range of pulse sequences to estimate R2∗...
June 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28642302/residual-erythropoiesis-protects-against-myocardial-hemosiderosis-in-transfusion-dependent-thalassemia-by-lowering-labile-plasma-iron-via-transient-generation-of-apotransferrin
#2
Maciej W Garbowski, Patricia Evans, Evangelia Vlachodimitropoulou, Robert Hider, John B Porter
Cardiosiderosis is a leading cause of mortality in transfusion-dependent thalassemias. Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis. Risk factors were identified in 73 patients with or without cardiosiderosis. Soluble transferrin receptor-1 levels were significantly lower in patients with cardiosiderosis (odds ratio 21). This risk increased when transfusion-iron loading rates exceeded the erythroid transferrin uptake rate (derived from soluble transferrin receptor-1) by >0...
June 22, 2017: Haematologica
https://www.readbyqxmd.com/read/28640222/albumin-and-hyaluronic-acid-coated-superparamagnetic-iron-oxide-nanoparticles-loaded-with-paclitaxel-for-biomedical-applications
#3
Elena Vismara, Chiara Bongio, Alessia Coletti, Ravit Edelman, Andrea Serafini, Michele Mauri, Roberto Simonutti, Sabrina Bertini, Elena Urso, Yehuda G Assaraf, Yoav D Livney
Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe₃O₄·DA-BSA/HA in water. Fe₃O₄·DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the paramagnetic relaxation properties of the preparation...
June 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28639348/cell-specificity-of-magnetic-cell-seeding-approach-to-hydrogel-colonization
#4
Raminder Singh, Anna Wieser, Supachai Reakasame, Rainer Detsch, Barbara Dietel, Christoph Alexiou, Aldo R Boccaccini, Iwona Cicha
Tissue-engineered scaffolds require an effective colonization with cells. Superparamagnetic iron oxide nanoparticles (SPIONs) can enhance cell adhesion to matrices by magnetic cell seeding. We investigated the possibility of improving cell attachment and growth on different alginate-based hydrogels using fibroblasts and endothelial cells loaded with SPIONs. Hydrogels containing pure alginate (Alg), alginate dialdehyde crosslinked with gelatin (ADA-G) and Alg blended with G or silk fibroin (SF) were prepared...
June 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28634793/arsenic-sorption-by-red-mud-modified-biochar-produced-from-rice-straw
#5
Chuan Wu, Liu Huang, Sheng-Guo Xue, Yu-Ying Huang, William Hartley, Meng-Qian Cui, Ming-Hung Wong
Red mud-modified biochar (RM-BC) has been produced to be utilized as a novel adsorbent to remove As because it can effectively combine the beneficial features of red mud (rich metal oxide composition and porous structure) and biochar (large surface area and porous structure properties). SEM-EDS and XRD analyses demonstrated that red mud had loaded successfully on the surface of biochar. With the increasing of pH in solution, arsenate (As(V)) adsorption on RM-BC decreased while arsenite (As(III)) increased. Arsenate adsorption kinetics process on RM-BC fitted the pseudo-second-order model, while that of As(III) favored the Elovich model...
June 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28631403/-pseudomonas-protegens-pf-5-favors-self-produced-siderophore-over-free-loading-in-interspecies-competition-for-iron
#6
D Joseph Sexton, Rochelle C Glover, Joyce E Loper, Martin Schuster
Many microorganisms compete for extracellular iron using strain-specific chelators known as siderophores. The ferric-siderophore complex limits local access to iron because import requires a suitable cognate receptor. Interestingly, many species carry receptors that enable "cross-feeding" on heterologous siderophores made by neighboring organisms, although little is known about how this ubiquitous behavior is regulated. Here, we investigated the soil bacterium Pseudomonas protegens Pf-5, a strain remarkable for its ability to use dozens of heterologous siderophores...
June 19, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28631037/inclusion-bodies-of-aggregated-hemosiderins-in-liver-macrophages
#7
Hisao Hayashi, Yasuaki Tatsumi, Shinya Wakusawa, Ryota Shigemasa, Ryoji Koide, Ken-Ichi Tsuchida, Natsuko Morotomi, Tetsuji Yamashita, Kotaro Kumagai, Yukiya Ono, Kazuhiko Hayashi, Masatoshi Ishigami, Hidemi Goto, Ayako Kato, Koichi Kato
Hemosiderin formation is a structural indication of iron overload. We investigated further adaptations of the liver to excess iron. Five patients with livers showing iron-rich inclusions larger than 2 µm were selected from our database. The clinical features of patients and structures of the inclusions were compared with those of 2 controls with mild iron overload. All patients had severe iron overload with more than 5000 ng/mL of serum ferritin. Etiologies were variable, from hemochromatosis to iatrogenic iron overload...
June 19, 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/28629084/facilitation-of-transscleral-drug-delivery-by-drug-loaded-magnetic-polymeric-particles
#8
Zeynab Mousavikhamene, Mohammad J Abdekhodaie, Hamid Ahmadieh
A unique method was used to facilitate ocular drug delivery from periocular route by drug loaded magnetic sensitive particles. Injection of particles in periocular space along the eye axis followed by application of magnetic field in front of the eye would trigger the magnetic polymeric particles to move along the direction of magnetic force and reside against the outer surface of the sclera. This technique prevents removal of drug in the periocular space, observed in conventional transscleral drug delivery systems and hence higher amount of drug can enter the eye in a longer period of time...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629053/a-novel-high-strength-and-highly-corrosive-biodegradable-fe-pd-alloy-structural-mechanical-and-in-vitro-corrosion-and-cytotoxicity-study
#9
Jaroslav Čapek, Šárka Msallamová, Eva Jablonská, Jan Lipov, Dalibor Vojtěch
Recently, iron-based materials have been considered as candidates for the fabrication of biodegradable load-bearing implants. Alloying with palladium has been found to be a suitable approach to enhance the insufficient corrosion rate of iron-based alloys. In this work, we have extensively compared the microstructure, the mechanical and corrosion properties, and the cytotoxicity of an FePd2 (wt%) alloy prepared by three different routes - casting, mechanical alloying and spark plasma sintering (SPS), and mechanical alloying and the space holder technique (SHT)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28627551/gold-loaded-nanoporous-iron-oxide-nanocubes-a-novel-dispersible-capture-agent-for-tumor-associated-autoantibody-analysis-in-serum
#10
Sharda Yadav, Mostafa Kamal Masud, Md Nazmul Islam, Vinod Gopalan, Alfred King-Yin Lam, Shunsuke Tanaka, Nam-Trung Nguyen, Md Shahriar Al Hossain, Cuiling Li, Md Yusuke Yamauchi, Muhammad J A Shiddiky
Autoantibodies are produced against tumor associated antigens (TAAs) long before the appearance of any symptoms and thus can serve as promising, non-invasive biomarkers for early diagnosis of cancer. Current conventional methods for autoantibody detection are highly invasive and mostly provide diagnosis in the later stages of cancer. Herein we report a new electrochemical method for early detection of p53 autoantibodies against colon cancer using a strategy that combines the strength of gold-loaded nanoporous iron oxide nanocube (Au@NPFe2O3NC)-based capture and purification while incorporating the inherent simplicity, inexpensive, and portable nature of the electrochemical and naked-eye colorimetric readouts...
June 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28625102/spatiotemporal-meta-analysis-reviewing-health-psychology-phenomena-over-space-and-time
#11
Blair T Johnson, Ellen K Cromley, Natasza Marrouch
Individual studies of health psychology are samples taken in particular places at particular times. The results of such studies manifest multiple processes, including those associated with individual, sample, intervention, and study design characteristics. Although extant meta-analyses of health phenomena have routinely considered these factors to explain heterogeneity, they have tended to neglect the environments where studies are conducted, which is ironic, as health phenomena cluster in space and times (e...
June 18, 2017: Health Psychology Review
https://www.readbyqxmd.com/read/28619730/consumption-of-a-high-iron-diet-disrupts-homeostatic-regulation-of-intestinal-copper-absorption-in-adolescent-mice
#12
Jung-Heun Ha, Caglar Doguer, James F Collins
High-iron feeding of rodents has been commonly used to model human iron-overload disorders. We recently noted that high-iron consumption impaired growth and caused severe systemic copper deficiency in growing rats, but the mechanism by which this occurred could not be determined due to technical limitations. In the current investigation, we thus utilized mice; first to determine if the same phenomenon occurred in another mammalian species, and secondly since we could assess in vivo copper absorption in mice...
June 15, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28616842/characterization-of-magneto-endosymbionts-as-mri-cell-labeling-and-tracking-agents
#13
Kimberly D Brewer, Ryan Spitler, Kayla R Lee, Andrea C Chan, Joyce C Barrozo, Abdul Wakeel, Chandler S Foote, Steven Machtaler, James Rioux, Juergen K Willmann, Papia Chakraborty, Bradley W Rice, Christopher H Contag, Caleb B Bell, Brian K Rutt
PURPOSE: Magneto-endosymbionts (MEs) show promise as living magnetic resonance imaging (MRI) contrast agents for in vivo cell tracking. Here we characterize the biomedical imaging properties of ME contrast agents, in vitro and in vivo. PROCEDURES: By adapting and engineering magnetotactic bacteria to the intracellular niche, we are creating magneto-endosymbionts (MEs) that offer advantages relative to passive iron-based contrast agents (superparamagnetic iron oxides, SPIOs) for cell tracking...
June 14, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28609747/the-enhancement-roles-of-layered-double-hydroxide-on-the-reductive-immobilization-of-selenate-by-nanoscale-zero-valent-iron-macroscopic-and-microscopic-approaches
#14
Baowei Hu, Feng Ye, Chengan Jin, Xiangxian Ma, Chengcai Huang, Guodong Sheng, Jingyuan Ma, Xiangke Wang, Yuying Huang
Herein, we utilized nanoscale zero-valent iron loaded on layered double hydroxide (NZVI/LDH) to immobilize Se(VI) and evaluated the enhancement role of LDH in the NZVI reaction system. The structural characterization indicated that LDH could stabilize and disperse NZVI as well as prevent NZVI from oxidation, thereby increasing iron reactivity. Batch experiments displayed that, compared with those by NZVI, both extent and rate of Se(VI) immobilized by NZVI/LDH significantly increased, owing to the prominent synergistic effect ascribing from adsorption and reduction...
June 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28609743/facile-synthesis-of-self-assembled-ultrathin-%C3%AE-feooh-nanorod-graphene-oxide-composites-for-supercapacitors
#15
Yuxue Wei, Ruimin Ding, Chenghua Zhang, Baoliang Lv, Yi Wang, Chengmeng Chen, Xiaoping Wang, Jian Xu, Yong Yang, Yongwang Li
A one-pot facile, impurity-free hydrothermal method to synthesize ultrathin α-FeOOH nanorods/graphene oxide (GO) composites is reported. It is directly synthesized from GO and iron acetate in water solution without inorganic or organic additives. XRD, Raman, FT-IR, XPS and TEM are used to characterize the samples. The nanorods in composites are single crystallite with an average diameter of 6nm and an average length of 75nm, which are significantly smaller than GO-free α-FeOOH nanorods. This can be attributed to the confinement effect and special electronic influence of GO...
May 31, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28609726/removal-of-tetracycline-from-aqueous-solution-by-mcm-41-zeolite-a-loaded-nano-zero-valent-iron-synthesis-characteristic-adsorption-performance-and-mechanism
#16
Yige Guo, Wenli Huang, Bin Chen, Ying Zhao, Dongfang Liu, Yu Sun, Bin Gong
In this study, nano zero valent iron (NZVI) modified MCM-41-zeolite A (Fe-MCM-41-A) composite as a novel adsorbent was prepared by precipitation method and applied for tetracycline (TC) removal from aqueous solution. The adsorbent was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray photoelectron spectroscopy (XPS) and N2-BET analysis. Hysteresis loops indicated that the sample has a desirable magnetic property and can be separated quickly...
June 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28597617/iron-monitoring-of-male-and-female-rugby-sevens-players-over-an-international-season
#17
Anthea C Clarke, Judith M Anson, Christine E Dziedzic, Warren A McDonald, David B Pyne
BACKGROUND: Given the likely influence that high training loads, contact-induced haemolysis and female-specific requirements have on the incidence of iron deficiency, characterising the direction and magnitude of fluctuations in iron status over an international season is important for managing player health and physical performance in rugby sevens. METHODS: Australian national male (n=27) and female (n=23) rugby sevens players undertook blood tests at pre-season, mid-season, and end-season...
June 8, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28596656/assessment-of-heart-and-liver-iron-overload-in-thalassemia-major-patients-using-t2-magnetic-resonance-imaging
#18
Hamid Farhangi, Zahra Badiei, Hasan Mottaghi Moghaddam, Mohammad Reza Keramati
Accumulation of excess iron in heart can lead to cardiac dysfunction, which is the most common cause of death in thalassemia major patients. Biopsy is an invasive procedure and therefore not an ideal option to assess iron load. However, standard/usual non-invasive methods, such as ferritin measurement, have some limitations and the results show poor correlations with iron load. Magnetic Response Imaging (MRI-T2*), as a non-invasive and reliable method for iron load assessment in organs such as liver and heart, can be suggested as a favorable alternative...
June 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28596536/enhanced-thermal-conductivity-and-dielectric-properties-of-iron-oxide-polyethylene-nanocomposites-induced-by-a-magnetic-field
#19
Qingguo Chi, Tao Ma, Jiufeng Dong, Yang Cui, Yue Zhang, Changhai Zhang, Shichong Xu, Xuan Wang, Qingquan Lei
Iron Oxide (Fe3O4) nanoparticles were deposited on the surface of low density polyethylene (LDPE) particles by solvothermal method. A magnetic field was introduced to the preparation of Fe3O4/LDPE composites, and the influences of the magnetic field on thermal conductivity and dielectric properties of composites were investigated systematically. The Fe3O4/LDPE composites treated by a vertical direction magnetic field exhibited a high thermal conductivity and a large dielectric constant at low filler loading...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28590063/highly-stable-three-dimensional-porous-nickel-iron-nitride-nanosheets-for-full-water-splitting-at-high-current-densities
#20
Feng Yan, Yue Wang, Kaiyue Li, Chunling Zhu, Peng Gao, Chunyan Li, Xitian Zhang, Yu-Jin Chen
A noble-metal-free and high-efficient bifunctional catalyst for overall water splitting is greatly desirable to generate clean and sustainable energy carrier such as hydrogen, but remains enormous challenges. Herein, we design and grow the porous interconnected iron-nickel nitride nanosheets on the carbon fiber cloth (FeNi-N/CFC) combing a facile electrodeposition method and in situ nitrogenization process. The as-synthesized FeNi-N/CFC with a low mass loading of 0.25 mg cm-2 exhibits excellent catalytic activities for both oxygen evolution reaction (OER) with 20 mA cm-2 at overpotential (η) of 232 mV and hydrogen evolution reaction (HER) with 10 mA cm-2 at η = 106 mV...
June 7, 2017: Chemistry: a European Journal
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