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Iron loading

Gabriela Wyszogrodzka, Przemysław Dorożyński, Barbara Gil, Wieslaw J Roth, Maciej Strzempek, Bartosz Marszałek, Władysław P Węglarz, Elżbieta Menaszek, Weronika Strzempek, Piotr Kulinowski
PURPOSE: The purpose of the study was initial evaluation of applicability of metal organic framework (MOF) Fe-MIL-101-NH2 as a theranostic carrier of antituberculous drug in terms of its functionality, i.e. drug loading, drug dissolution, magnetic resonance imaging (MRI) contrast and cytotoxic safety. METHODS: Fe-MIL-101-NH2 was characterized using X-ray powder diffraction, FTIR spectrometry and scanning electron microscopy. The particle size analysis was determined using laser diffraction...
May 18, 2018: Pharmaceutical Research
Felix Sigmund, Christoph Massner, Philipp Erdmann, Anja Stelzl, Hannes Rolbieski, Mitul Desai, Sarah Bricault, Tobias P Wörner, Joost Snijder, Arie Geerlof, Helmut Fuchs, Martin Hrabĕ de Angelis, Albert J R Heck, Alan Jasanoff, Vasilis Ntziachristos, Jürgen Plitzko, Gil G Westmeyer
We genetically controlled compartmentalization in eukaryotic cells by heterologous expression of bacterial encapsulin shell and cargo proteins to engineer enclosed enzymatic reactions and size-constrained metal biomineralization. The shell protein (EncA) from Myxococcus xanthus auto-assembles into nanocompartments inside mammalian cells to which sets of native (EncB,C,D) and engineered cargo proteins self-target enabling localized bimolecular fluorescence and enzyme complementation. Encapsulation of the enzyme tyrosinase leads to the confinement of toxic melanin production for robust detection via multispectral optoacoustic tomography (MSOT)...
May 18, 2018: Nature Communications
Eric C Abenojar, Sameera Wickramasinghe, Minseon Ju, Sarika Uppaluri, Alison Klika, Jaiben George, Wael Barsoum, Salvatore J Frangiamore, Carlos A Higuera-Rueda, Anna Cristina S Samia
Bacterial biofilms are highly antibiotic resistant microbial cell associations that lead to chronic infections. Unlike free-floating planktonic bacterial cells, the biofilms are encapsulated in a hardly penetrable extracellular polymeric matrix and, thus, demand innovative approaches for treatment. Recent advancements on the development of gel-nanocomposite systems with tailored therapeutic properties provide promising routes to develop novel antimicrobial agents that can be designed to disrupt and completely eradicate preformed biofilms...
May 18, 2018: ACS Infectious Diseases
Rafiou Agoro, Meriem Taleb, Valerie F J Quesniaux, Catherine Mura
Macrophages play crucial roles in innate immune response and in the priming of adaptive immunity, and are characterized by their phenotypic heterogeneity and plasticity. Reprogramming intracellular metabolism in response to microenvironmental signals is required for M1/M2 macrophage polarization and function. Here we assessed the influence of iron on the polarization of the immune response in vivo and in vitro. Iron-enriched diet increased M2 marker Arg1 and Ym1 expression in liver and peritoneal macrophages, while iron deficiency decreased Arg1 expression...
2018: PloS One
Xin Wen, Huanhuan Zhang, Fei Tian, Xiaofang Liu, Libo Niu, Guoyi Bai
A novel H3PW12O40 deposited chitosan coated iron oxide magnetic core-shell nanocomposite (Fe3O4@CS@HPW) was prepared via a facile approach. Fe3O4 nanoparticles were first coated with crosslinking-agent-free chitosan, and then H3PW12O40 was loaded onto the surface of chitosan as an outer shell. The resultant nanocomposite was well characterized by Brunauer-Emmett-Teller surface area analysis (BET), inductively coupled plasma analysis (ICP), X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and elemental mappings...
January 1, 2018: Journal of Nanoscience and Nanotechnology
Wilbert S Aronow
Iron-overload syndromes may be hereditary or acquired. Patients may be asymptomatic early in the disease. Once heart failure develops, there is rapid deterioration. Cardiac hemochromatosis is characterized by a dilated cardiomyopathy with dilated ventricles, reduced ejection fraction, and reduced fractional shortening. Deposition of iron may occur in the entire cardiac conduction system, especially the atrioventricular node. Cardiac hemochromatosis should be considered in any patient with unexplained heart failure...
April 2018: Archives of Medical Science: AMS
Ruta Gruskiene, Tatjana Krivorotova, Ramune Staneviciene, Dalius Ratautas, Elena Serviene, Jolanta Sereikaite
Nisin is a known bacteriocin approved as a food additive for food preservation. It exhibits a wide spectrum antimicrobial activity against Gram-positive bacteria. Iron oxide magnetic nanoparticles were synthesized and characterized by X-ray diffraction method. A main part of iron oxide nanoparticles was found to be maghemite though a small quantity of magnetite could also be present. Magnetic nanoparticles were stabilized by citric, ascorbic, gallic or glucuronic acid coating. Stable iron oxide magnetic nanoparticles were functionalized by nisin using a simple and low cost adsorption method...
May 8, 2018: Colloids and Surfaces. B, Biointerfaces
Jing Liu, Shengming Wan, Yun Zhang, Shu Zhang, Hongying Zhang, Shiwen Wu
Heat stroke, the most serious type of heat illness, refers to the presence of hyperthermia (core temperature >40°C), accompanied by central nervous system dysfunction. The hippocampus is a particularly vulnerable region in the early stage of heat stroke. Increasing evidence suggests that dysregulation of brain iron metabolism is involved in many neurodegenerative diseases. However, whether heat stroke causes dysfunction of iron metabolism, as well as iron-regulatory proteins, in the hippocampus remains unknown...
May 11, 2018: Shock
Chuan Wu, MengQian Cui, ShengGuo Xue, WaiChin Li, Liu Huang, XingXing Jiang, ZiYan Qian
Arsenic contamination in paddy soils has aroused global concern due to its threats to food security and human health. Biochar modified with different iron materials was prepared for arsenic (As) immobilization in contaminated soils. Soil incubation experiments were carried to investigate the effects of biochar modified with Fe-oxyhydroxy sulfate (Biochar-FeOS), FeCl3 (Biochar-FeCl3 ), and zero-valent iron (Biochar-Fe) on the pH, NaHCO3 -extractable As concentrations, and the As fractions in soils. The scanning electron microscope and X-ray diffraction analysis demonstrated that iron was successfully loaded onto the surface or embedded into the pores of the biochar...
May 13, 2018: Environmental Science and Pollution Research International
Natthaphat Siri-Angkul, Siriporn C Chattipakorn, Nipon Chattipakorn
Thalassemia is among the most common genetic diseases. Patients with severe forms of the disease are transfusion-dependent, leading to iron overload. A condition which can eventually develop in the iron-loaded heart is iron overload cardiomyopathy, a debilitating disease that accounts for the majority of deaths in thalassemia patients. Areas covered: This review article provides a comprehensive summary of the diagnosis and treatment of cardiac iron overload in transfusion-dependent thalassemia patients, with discussion covering current weak points and potential improvements of the relevant diagnostic and therapeutic strategies...
May 12, 2018: Expert Review of Hematology
Graham Cuff, Ariel E Turcios, Ehsan Mohammad-Pajooh, Olaf Kujawski, Dirk Weichgrebe, Karl-Heinz Rosenwinkel
At an Austrian soft drink company, an expanded granular sludge bed reactor for anaerobic wastewater treatment was inoculated with sludge from paper and food industries. Detailed online monitoring and laboratory examinations were carried out during startup and subsequent phases, which included a period of inhibition after ca. 80 days during which reactor degradative performance diminished suddenly, following a period of increased effluent VFA. After dosing iron chloride (FeCl2 ) and micronutrients and reducing organic loading to startup levels, the reactor eventually reached efficient operation (>85% COD degradation) after a gradual recovery phase...
May 10, 2018: Journal of Environmental Management
Jianjun Hu, Chong Li, Qianhui Guo, Jiatao Dang, Quanguo Zhang, Duu-Jong Lee, Yunlong Yang
The iron-based oxygen carriers (OC's), Fe2 O3 /support (Al2 O3 , TiO2 , SiO2 and ZrO2 ), for chemical looping gasification of wheat straw were prepared using impregnation method. The surface morphology, crystal structure, carbon deposition potential, lattice oxygen activity and selectivity of the yielded OCs were examined. The Fe2 O3 /Al2 O3 OCs at 60% loading has the highest H2 yield, H2 /CO ratio, gas yield, and carbon conversion amongst the tested OC's. Parametric studies revealed that an optimal loading Fe2 O3 of 60%, steam-to-biomass ratio of 0...
May 3, 2018: Bioresource Technology
Jie Han, Guilong Zhang, Linglin Zhou, Furu Zhan, Dongqing Cai, Zhengyan Wu
A new nanocomposite (SCZ), micro spherical carbon (SC) loaded with nanoscale zero-valent iron (ZVI), was fabricated to efficiently remove hexavalent chromium (Cr(VI)) from water. Therein, SC was derived from waste carton through hydrothermal treatment after pretreatment of removing hemicellulose and lignin, and the optimal hydrothermal conditions (200oC, hydrothermal time of 12 h) for the preparation of SC were obtained. Subsequently, SC could be used as an ideal carrier for ZVI nano particles which distributed evenly on the surface of SC and in the pores among SC particles, favoring the dispersion of ZVI through steric hindrance effect...
May 11, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Chengcheng Li, Zhibin Luo, Tuo Wang, Jinlong Gong
Collecting and storing solar energy to hydrogen fuel through a photo-electrochemical (PEC) cell provides a clean and renewable pathway for future energy demands. Having earth-abundance, low biotoxicity, robustness, and an ideal n-type band position, hematite (α-Fe2 O3 ), the most common natural form of iron oxide, has occupied the research hotspot for decades. Here, a close look into recent progress of hematite photoanodes for PEC water splitting is provided. Effective approaches are introduced, such as cocatalysts loading and surface passivation layer deposition, to improve the hematite surface reaction in thermodynamics and kinetics...
May 11, 2018: Advanced Materials
Geoffrey D Shimberg, Jordan D Pritts, Sarah L J Michel
Zinc finger (ZF) proteins are proteins that use zinc as a structural cofactor. The common feature among all ZFs is that they contain repeats of four cysteine and/or histidine residues within their primary amino acid sequence. With the explosion of genome sequencing in the early 2000s, a large number of proteins were annotated as ZFs based solely upon amino acid sequence. As these proteins began to be characterized experimentally, it was discovered that some of these proteins contain iron-sulfur sites either in place of or in addition to zinc...
2018: Methods in Enzymology
Guo-Xing Zhu, Xulan Xie, Xiaoyun Li, Yuanjun Liu, Xiaoping Shen, Keqiang Xu, Shaowei Chen
FeCo-based materials are promising candidates as efficient, affordable, and sustainable electrocatalysts for oxygen evolution reaction (OER). Herein, a composite based on FeSe2@CoSe2 particles supported on reduced graphene oxide (rGO) was successfully prepared as OER catalyst. In the catalyst, the CoSe2 phase was located on the FeSe2 surface, forming a large number of exposed heterointerfaces with acidic iron sites, due to strong charge interaction between CoSe2 and FeSe2. It is believed that the exposed heterointerfaces act as catalytic active sites for OER via a two-site mechanism, manifesting an overpotential as low as 260 mV to reach the current density of 10 mA cm-2 in 1 M of KOH and excellent stability for at least 6 h, which is superior to CoSe2/rGO, FeSe2/rGO, as well as most of FeNi- and FeCo-based electrocatalysts reported in recent literatures...
May 9, 2018: ACS Applied Materials & Interfaces
Shan Liang, Yu Huang, Youn Young Shim, Xiang Ma, Martin John Tarsisius Reaney, Yong Wang
Nanocomposites, based on iron salts and soluble flaxseed gum (FG), were prepared as potential treatments of iron deficiency anemia (IDA). FG was extracted, characterized, and formulated into iron-loading nanocomposites via ion-exchange against FeCl3, Fe2(SO4)3, FeCl2 and FeSO4·7H2O. FG-iron nanocomposites preparation condition was optimized, and physicochemical properties of the nanocomposites were investigated. In vitro release kinetics of iron in simulated gastric fluid (SGF) were also evaluated. FG heteropolysaccharide consisting of rhamnose (33...
May 8, 2018: Journal of Agricultural and Food Chemistry
Aravind Puthirath Balan, Sruthi Radhakrishnan, Cristiano F Woellner, Shyam K Sinha, Liangzi Deng, Carlos de Los Reyes, Banki Manmadha Rao, Maggie Paulose, Ram Neupane, Amey Apte, Vidya Kochat, Robert Vajtai, Avetik R Harutyunyan, Ching-Wu Chu, Gelu Costin, Douglas S Galvao, Angel A Martí, Peter A van Aken, Oomman K Varghese, Chandra Sekhar Tiwary, Anantharaman Malie Madom Ramaswamy Iyer, Pulickel M Ajayan
With the advent of graphene, the most studied of all two-dimensional materials, many inorganic analogues have been synthesized and are being exploited for novel applications. Several approaches have been used to obtain large-grain, high-quality materials. Naturally occurring ores, for example, are the best precursors for obtaining highly ordered and large-grain atomic layers by exfoliation. Here, we demonstrate a new two-dimensional material 'hematene' obtained from natural iron ore hematite (α-Fe2 O3 ), which is isolated by means of liquid exfoliation...
May 7, 2018: Nature Nanotechnology
Deborah Stefanova, Antoan Raychev, Jaime Deville, Romney Humphries, Shelley Campeau, Piotr Ruchala, Elizabeta Nemeth, Tomas Ganz, Yonca Bulut
Iron is an essential micronutrient for most microbes and their hosts. Mammalian hosts respond to infection by inducing the iron-regulatory hormone hepcidin, which causes iron sequestration and a rapid decrease in plasma and extracellular iron concentration (hypoferremia). Previous studies showed that hepcidin regulation of iron is essential for protection from infection-associated mortality with the siderophilic pathogens Yersinia enterocolitica and Vibrio vulnificus However, the evolutionary conservation of the hypoferremic response to infection suggests that not only rare siderophilic bacteria but also common pathogens may be targeted by this mechanism...
May 7, 2018: Infection and Immunity
Daren Liu, Xiaowen Li, Changlei Chen, Chao Li, Chuanbiao Zhou, Weidong Zhang, Jiangang Zhao, Jie Fan, Kai Cheng, Li Chen
Gastric cancer is the fourth most common malignancy globally. In order to decrease the dosage and side effects of conventional chemotherapy, and achieve improved benefits from molecular targeted therapy, novel drug delivery systems were developed in the present study. Oxaliplatin-Au-Fe3 O4 -Herceptin® acts as a dual-functional nanoparticles (NPs) conjugate and possesses the capability of human epithelial growth factor receptor 2 (HER2) targeting and oxaliplatin delivery. The 8-20 nm Au-Fe3 O4 were synthesized by decomposing iron pentacarbonyl on the surfaces of Au NPs in the presence of oleic acid and oleylamine...
May 2018: Oncology Letters
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