keyword
MENU ▼
Read by QxMD icon Read
search

Iron loading

keyword
https://www.readbyqxmd.com/read/28532109/lactoferrin-modified-graphene-oxide-iron-oxide-nanocomposite-for-glioma-targeted-drug-delivery
#1
Meng-Meng Song, Huai-Liang Xu, Jun-Xing Liang, Hui-Hui Xiang, Rui Liu, Yu-Xian Shen
Targeting delivery of drugs in a specific manner represents a potential powerful technology in gliomas. Herein, we prepared a multifunctional targeted delivery system based on graphene oxide (GO) that contains a molecular bio-targeting ligand and superparamagnetic iron oxide nanoparticles on the surface of GO for magnetic targeting. Superparamagnetic Fe3O4 nanoparticles was loaded on the surface of GO via chemical precipitation method to form GO@Fe3O4 nanocomposites. Lactoferrin (Lf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells and vascular endothelial cell of the blood brain barrier, was chosen as the targeted ligand to construct the targeted delivery system Lf@GO@Fe3O4 through EDC/NHS chemistry...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531979/synthesis-and-characterization-of-glycyrrhizic-acid-coated-iron-oxide-nanoparticles-for-hyperthermia-applications
#2
Mostafa Saeedi, Omid Vahidi, Shahin Bonakdar
In the present study, iron oxide magnetic nanoparticles (IONPs) were synthesized using the oxidative precipitation method for biomedical applications. Glycyrrhizic acid (GA) extracted from the roots of licorice plant was used as the coating agent for the synthesized nanoparticles (GAIONPs). The crystal phase, morphology and size were investigated by XRD, FE-SEM and TEM. The saturation magnetization (ms) value of the nanoparticles was measured by VSM indicating lowered ms of the GAIONPs with respect to that of the IONPs due to the presence of GA...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530105/effect-of-humic-acid-on-the-removal-of-chromium-vi-and-the-production-of-solids-in-iron-electrocoagulation
#3
Chao Pan, Lyndsay D Troyer, Peng Liao, Jeffrey G Catalano, Wenlu Li, Daniel E Giammar
Iron-based electrocoagulation can be highly effective for Cr(VI) removal from water supplies. However, the presence of humic acid (HA) inhibited the rate of Cr(VI) removal in electrocoagulation, with the greatest decreases in Cr(VI) removal rate at higher pH. This inhibition was probably due to the formation of Fe(II) complexes with HA that are more rapidly oxidized than uncomplexed Fe(II) by dissolved oxygen, making less Fe(II) available for reduction of Cr(VI). Close association of Fe(III), Cr(III), and HA in the solid products formed during electrocoagulation influenced the fate of both Cr(III) and HA...
May 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28529891/biomonitorization-of-iron-accumulation-in-the-substantia-nigra-from-lewy-body-disease-patients
#4
Belén Fernández, Isidro Ferrer, Fernando Gil, Sabine Hilfiker
Iron levels in the healthy human brain are known to be high in certain areas such as the substantia nigra (SN), and increase further with age. In addition, there is some evidence for a further increase in iron load in the SN of Parkinson's disease (PD) patients as compared to controls, which correlates with motor disability. Here, we have analyzed total iron levels in cells as well as mouse and human brain samples by atomic absorption spectroscopy (AAS). Our data indicate that iron load is more pronounced in cells with dopaminergic features...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28524364/biofunctional-microgel-based-fertilizers-for-controlled-foliar-delivery-of-nutrients-to-plants
#5
Richard A Meurer, Steffen Kemper, Sandra Knopp, Thomas Eichert, Felix Jakob, Heiner E Goldbach, Ulrich Schwaneberg, Andrij Pich
Foliar application of micronutrients (e.g. Fe(3+) ) onto plants over an extended time is challenging and often not possible due to insufficient rainfastness. Smart delivery systems which enable micronutrient release over several weeks would offer innovative and sustainable options to improve plant health and food production. Herein, we report a novel foliar fertilizer delivery system based on functional pH-responsive biohybrid microgels that have orthogonal functionality as carriers of micronutrients and employ peptides (termed anchor peptides) as foliar adhesion promoters...
May 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28521168/ecotoxicity-testing-and-environmental-risk-assessment-of-iron-nanomaterials-for-sub-surface-remediation-recommendations-from-the-fp7-project-nanorem
#6
Rune Hjorth, Claire Coutris, Nhung H A Nguyen, Alena Sevcu, Juliàn Alberto Gallego-Urrea, Anders Baun, Erik J Joner
Nanoremediation with iron (Fe) nanomaterials opens new doors for treating contaminated soil and groundwater, but is also accompanied by new potential risks as large quantities of engineered nanomaterials are introduced into the environment. In this study, we have assessed the ecotoxicity of four engineered Fe nanomaterials, specifically, Nano-Goethite, Trap-Ox Fe-zeolites, Carbo-Iron(®) and FerMEG12, developed within the European FP7 project NanoRem for sub-surface remediation towards a test battery consisting of eight ecotoxicity tests on bacteria (V...
May 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28515324/the-diferric-tyrosyl-radical-cluster-of-ribonucleotide-reductase-and-cytosolic-iron-sulfur-clusters-have-distinct-and-similar-biogenesis-requirements
#7
Haoran Li, Martin Stümpfig, Caiguo Zhang, Xiuxiang An, JoAnne Stubbe, Roland Lill, Mingxia Huang
How each metalloprotein assembles the correct metal at the proper binding site presents challenges to the cell. The di-iron enzyme ribonucleotide reductase (RNR) uses a diferric-tyrosyl radical (Fe(III)2-Y·) cofactor to initiate nucleotide reduction. Assembly of this cofactor requires O2, Fe(II), and a reducing equivalent. Recent studies show that RNR cofactor biosynthesis shares the same source of iron, in the form of [2Fe-2S]-GSH2 from the monothiol glutaredoxin Grx3/4, and the same electron source, in the form of the Dre2-Tah18 electron transfer chain, with the cytosolic iron-sulfur protein assembly (CIA) machinery required for maturation of [4Fe-4S] clusters in cytosolic and nuclear proteins...
May 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28513646/biocompatibility-and-therapeutic-evaluation-of-magnetic-liposomes-designed-for-self-controlled-cancer-hyperthermia-and-chemotherapy
#8
Manashjit Gogoi, Manish K Jaiswal, Haladhar Dev Sarma, Dhirendra Bahadur, Rinti Banerjee
Magnetic liposome-mediated combined chemotherapy and hyperthermia is gaining importance as an effective therapeutic modality for cancer. However, control and maintenance of optimum hyperthermia are major challenges in clinical settings due to the overheating of tissues. To overcome this problem, we developed a novel magnetic liposomes formulation co-entrapping a dextran coated biphasic suspension of La0.75Sr0.25MnO3 (LSMO) and iron oxide (Fe3O4) nanoparticles for self-controlled hyperthermia and chemotherapy...
May 17, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28511389/variability-of-iron-load-in-patients-of-sickle-cell-anaemia-hbss-a-study-from-eastern-india
#9
Pranati Mohanty, Rabindra Kumar Jena, Sudha Sethy
INTRODUCTION: Sickle Cell Anaemia (SCA) is one of the commonest haemoglobinopathies due to a point mutation (A→T) of the β-globin gene. Out of five haplotypes, the Arab-Indian haplotype present in India is one of the least severe phenotype and least studied also. It is characterized by lifelong haemolytic anaemia requiring red cell transfusion leading to iron overload. In contrast, there is very high incidence of deficiency of iron, folic acid and vitamin B12. AIM: Our objective was to access the Iron status of SCA patients and to find its correlation with various parameters like red cell transfusion, haemolysis and serum hepcidin...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28504463/magnetocatalytic-graphene-quantum-dots-janus-micromotors-for-bacterial-endotoxin-detection
#10
Beatriz Jurado-Sánchez, Marta Pacheco, Jaime Rojo, Alberto Escarpa
Magnetocatalytic hybrid Janus micromotors encapsulating phenylboronic acid (PABA) modified graphene quantum dots (GQDs) are described herein as ultrafast sensors for the detection of deadly bacteria endotoxins. A bottom-up approach was adopted to synthesize an oil-in-water emulsion containing the GQDs along with a high loading of platinum and iron oxide nanoparticles on one side of the Janus micromotor body. The two different "active regions" enable highly efficient propulsion in the presence of hydrogen peroxide or magnetic actuation without the addition of a chemical fuel...
May 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28504147/synthesis-and-characterization-of-cellulose-goethite-composites-and-their-adsorption-properties-with-roxarsone
#11
Dexu Kong, Lee D Wilson
This study reports on the preparation of goethite and its supported forms onto cellulose as adsorbents for the adsorption of 4-hydroxy-3-nitrobenzene arsenic acid (roxarsone) from aqueous solution. Goethite nanoparticles (NPs) and their cellulose composites were prepared with good yield ∼97%, and characterized by thermal gravimetric analysis (TGA), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, nitrogen gas adsorption/desorption (BET), powder X-ray diffraction (pXRD) and transmission electron microscopy (TEM)...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28497842/macrophagic-enhancement-in-optical-coherence-tomography-imaging-by-means-of-superparamagnetic-iron-oxide-nanoparticles
#12
Juan Luis Gutiérrez-Chico, Milosz Jaguszewski, Miguel Comesaña-Hermo, Miguel Ángel Correa-Duarte, Luis Mariñas-Pardo, Manuel Hermida-Prieto
BACKGROUND: The ability of optical coherence tomography (OCT) to visualise macrophages in vivo in coronary arteries is still controversial. We hypothesise that imaging of macrophages in OCT could be enhanced by means of superparamagnetic nanoparticles. METHODS: We compared the optical backscattering and attenuation of cell pellets containing RAW 264.7 macrophages with those of macrophagic cell pellets labelled with very small superparamagnetic oxydised nanoparticles (VSOP) by means of light intensity analysis in OCT...
May 12, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28496458/preparation-optimization-and-toxicity-evaluation-of-spion-plga-%C3%A2-peg-nanoparticles-loaded-with-gemcitabine-as-a-multifunctional-nanoparticle-for-therapeutic-and-diagnostic-applications
#13
Nima Hamzian, Maryam Hashemi, Mahdi Ghorbani, Mohammad Hossein Bahreyni Toosi, Mohammad Ramezani
The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and Gemcitabine in PLGA ± PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were simultaneously synthesized and encapsulated with Gemcitabine (Gem) in PLGA ± PEG copolymers via W/O/W double emulsification method. Optimum size and encapsulation efficiency for radiosensitization, hyperthermia and diagnostic applications were considered and the preparation parameters systematically were investigated and physicochemical characteristics of optimized nanoparticle were studied...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28494309/macroscopic-and-spectroscopic-studies-of-the-enhanced-scavenging-of-cr-vi-and-se-vi-from-water-by-titanate-nanotube-anchored-nanoscale-zero-valent-iron
#14
Baowei Hu, Guohe Chen, Chengan Jin, Jun Hu, Chengcai Huang, Jiang Sheng, Guodong Sheng, Jingyuan Ma, Yuying Huang
Herein, a promising titanate nanotubes (TNT) anchored nanoscale zero-valent iron (NZVI) nanocomposite (NZVI/TNT) was synthesized, characterized and used for the enhanced scavenging of Cr(VI) and Se(VI) from water. The structural identification indicated that NZVI was uniformly loaded on TNT, thereby, the oxidation and aggregation of NZVI was significantly minimized. The macroscopic experimental results indicated that NZVI/TNT exhibited higher efficiency as well as rate on Cr(VI) and Se(VI) scavenging resulted from the good synergistic effect between adsorption and reduction...
April 28, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28494265/intramyocardial-fate-and-effect-of-iron-nanoparticles-co-injected-with-macs-%C3%A2-purified-stem-cell-products
#15
Paula Müller, Ralf Gaebel, Heiko Lemcke, Frank Wiekhorst, Frauke Hausburg, Cajetan Lang, Nicole Zarniko, Bernd Westphal, Gustav Steinhoff, Robert David
BACKGROUND: Magnetic activated cell sorting (MACS(®)) is routinely used to isolate stem cell subpopulations intended for the treatment of cardiovascular diseases. In strong contrast, studies examining the amount, effect and intramyocardial distribution of iron nanoparticles used for magnetic cell labelling are missing, although iron excess can cause functional disorders in the heart. METHODS AND RESULTS: CD133(+) haematopoietic and CD271(+) mesenchymal stem cells were purified from bone marrow using automatically and manually MACS(®) based systems...
May 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28492491/magnetic-cationic-amylose-nanoparticles-used-to-deliver-survivin-small-interfering-rna-for-gene-therapy-of-hepatocellular-carcinoma-in-vitro
#16
Zhuo Wu, Xiao-Lin Xu, Jun-Zhao Zhang, Xu-Hong Mao, Ming-Wei Xie, Zi-Liang Cheng, Lie-Jing Lu, Xiao-Hui Duan, Li-Ming Zhang, Jun Shen
Amylose is a promising nanocarrier for gene delivery in terms of its good biocompatibility and high transfection efficiency. Small interfering RNA against survivin (survivin-siRNA) can cause tumor apoptosis by silencing a hepatocellular carcinoma (HCC)-specific gene at the messenger RNA level. In this study, we developed a new class of folate-functionalized, superparamagnetic iron oxide (SPIO)-loaded cationic amylose nanoparticles to deliver survivin-siRNA to HCC cells. The cellular uptake of nanocomplexes, cytotoxicity, cell apoptosis, and gene suppression mediated by siRNA-complexed nanoparticles were tested...
May 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28487625/a-comparative-study-of-raw-and-metal-oxide-impregnated-carbon-nanotubes-for-the-adsorption-of-hexavalent-chromium-from-aqueous-solution
#17
Muhammad I Qureshi, Faheemuddin Patel, Nadhir Al-Baghli, Basim Abussaud, Bassam S Tawabini, Tahar Laoui
The present study reports the use of raw, iron oxide, and aluminum oxide impregnated carbon nanotubes (CNTs) for the adsorption of hexavalent chromium (Cr(VI)) ions from aqueous solution. The raw CNTs were impregnated with 1% and 10% loadings (weight %) of iron oxide and aluminum oxide nanoparticles using wet impregnation technique. The synthesized materials were characterized using scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). Batch adsorption experiments were performed to assess the removal efficiency of Cr(VI) ions from water and the effects of pH, contact time, adsorbent dosage, and initial concentration of the Cr(VI) ions were investigated...
2017: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/28487188/poly-acrylic-acid-microspheres-loaded-with-superparamagnetic-iron-oxide-nanoparticles-for-transcatheter-arterial-embolization-and-mri-detectability-in-vitro-and-in-vivo-evaluation
#18
Zi-Yuan Li, Xiao-Ya Qin, Li-Ying Guo, Huan Wang, Xiao-Xin Liu, Zhuo-Zhao Zheng, Hai-Tao Guan, Li Song, Ying-Hua Zou, Tian-Yuan Fan
To develop embolic microspheres with MRI detectability, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized and mixed with monomer of acrylic acid to prepare SPIONs-loaded polymerized microspheres (SPMs) by inverse suspension polymerization method. The SPMs were evaluated for the ability of embolization by investigating the morphology, particle size, elasticity and renal arterial embolization to rabbits. Meanwhile, the loading of SPIONs was verified by optical microscope, transmission electron microscope, Fourier transform infrared spectrum, vibrating sample magnetometer, X-ray diffraction and X-ray photoelectron spectroscopy, and the content of SPIONs in SPMs was measured quantitatively...
May 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28482580/luteinizing-hormone-releasing-hormone-targeted-superparamagnetic-gold-nanoshells-for-a-combination-therapy-of-hyperthermia-and-controlled-drug-delivery
#19
Faruq Mohammad, Hamad A Al-Lohedan
In this, we developed superparamagnetic iron oxide nanoparticles (SPIONs) to be appropriate for the diagnosis and treatment of cancer cells by means of magnetic resonance imaging (MRI) and magnetically controlled hyperthermia/drug delivery (respectively). For the preparation of composite, we started with SPIONs, followed by its coating with gold to form SPIONs@Au, which further conjugated with luteinizing hormone-releasing hormone (LHRH) protein by making use of the cysteamine (Cyst) space linker and finally loaded with 5-Fluororacil (5-Fu) anticancer drug to form SPIONs@Au-Cyst-LHRH_5-Fu composite...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482548/innovative-superparamagnetic-iron-oxide-nanoparticles-coated-with-silica-and-conjugated-with-linoleic-acid-effect-on-tumor-cell-growth-and-viability
#20
Giuliana Muzio, Marta Miola, Sara Ferraris, Marina Maggiora, Elisa Bertone, Maria Paola Puccinelli, Marina Ricci, Ester Borroni, Rosa Angela Canuto, Enrica Verné, Antonia Follenzi
One of the goals for the development of more effective cancer therapies with reduced toxic side effects is the optimization of innovative treatments to selectively kill tumor cells. The use of nanovectors loaded with targeted therapeutic payloads is one of the most investigated strategies. In this paper superparamagnetic iron oxide nanoparticles (SPIONs) coated by a silica shell or uncoated, were functionalized with single-layer and bi-layer conjugated linoleic acid (CLA). Silica was used to protect the magnetic core from oxidation, improve the stability of SPIONs and tailor their surface reactivity...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
keyword
keyword
54101
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"