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https://www.readbyqxmd.com/read/28432630/the-influence-of-restoration-measures-on-phosphorus-internal-loading-from-the-sediments-of-a-hypereutrophic-lake
#1
Katarzyna Kowalczewska-Madura, Renata Dondajewska, Ryszard Gołdyn, Stanisław Podsiadłowski
Uzarzewskie Lake was a hypereutrophic, dimictic lake characterized by low water transparency, high chlorophyll-a concentration and intense phytoplankton blooms; thus, restoration treatment was started. A chemical treatment, based on phosphorus inactivation with small doses of iron sulphate, was undertaken in 2006-2007. Nitrate-rich groundwater flowing from seepage springs was directed into the lake hypolimnion to increase redox potential since 2008. Phosphorus internal loading was reduced by more than 80% as a result of restoration treatment...
April 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28431372/down-flow-fixed-structured-bed-reactor-an-innovative-reactor-configuration-applied-to-acid-mine-drainage-treatment-and-metal-recovery
#2
Leandro Augusto Gouvêa de Godoi, Eugenio Foresti, Márcia Helena Rissato Zamariolli Damianovic
A down-flow fixed-structured bed reactor (DFSBR) was operated for 277 days treating a mixture of synthetic substrates simulating an iron-rich acid mine drainage (AMD) and the soluble fraction of a sugarcane vinasse. The synthetic sugarcane vinasse was used as electron donor for biological sulfate-reduction, resulting in influent chemical oxygen demand (COD) close to 4000 mg L(-1) and volumetric organic loading rate of 4.8 g L(-1)d(-1). The influent sulfate concentration was kept close to 2000 mg L(-1) (volumetric sulfate loading rate of 2...
April 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28431327/dendrimer-conjugated-iron-oxide-nanoparticles-as-stimuli-responsive-drug-carriers-for-thermally-activated-chemotherapy-of-cancer
#3
Saumya Nigam, Dhirendra Bahadur
In recent years, functional nanomaterials have found an appreciable place in the understanding and treatment of cancer. This work demonstrates the fabrication and characterization of a new class of cationic, biocompatible, peptide dendrimers, which were then used for stabilizing and functionalizing magnetite nanoparticles for combinatorial therapy of cancer. The synthesized peptide dendrimers have an edge over the widely used PAMAM dendrimers due to better biocompatibility and negligible cytotoxicity of their degradation products...
April 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28430880/cerebral-abscess-associated-with-odontogenic-bacteremias-hypoxemia-and-iron-loading-in-immunocompetent-patients-with-right-to-left-shunting-through-pulmonary-arteriovenous-malformations
#4
E J Boother, S Brownlow, H C Tighe, K B Bamford, J E Jackson, C L Shovlin
Background: Cerebral abscess is a recognised complication of pulmonary arteriovenous malformations (PAVMs) that allow systemic venous blood to bypass the pulmonary capillary bed through anatomic right-to-left shunts. Broader implications and mechanisms remain poorly explored. Methods: Between June 2005 and December 2016, at a single institution, 445 consecutive adult patients with CT-scan confirmed PAVMs (including 403 (90.5%) with hereditary haemorrhagic telangiectasia) were recruited to a prospective series...
April 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28430694/iron-loading-exaggerates-the-inflammatory-response-to-the-toll-like-receptor-4-ligand-lipopolysaccharide-by-altering-mitochondrial-homeostasis
#5
Konrad Hoeft, Donald B Bloch, Jan A Graw, Rajeev Malhotra, Fumito Ichinose, Aranya Bagchi
BACKGROUND: Perioperative and critically ill patients are often exposed to iron (in the form of parenteral-iron administration or blood transfusion) and inflammatory stimuli, but the effects of iron loading on the inflammatory response are unclear. Recent data suggest that mitochondrial reactive oxygen species have an important role in the innate immune response and that increased mitochondrial reactive oxygen species production is a result of dysfunctional mitochondria. We tested the hypothesis that increased intracellular iron potentiates lipopolysaccharide-induced inflammation by increasing mitochondrial reactive oxygen species levels...
April 21, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28427421/cerebrospinal-fluid-csf-biomarkers-of-iron-status-are-associated-with-csf-viral-load-antiretroviral-therapy-and-demographic-factors-in-hiv-infected-adults
#6
Stephanie M Patton, Quan Wang, Todd Hulgan, James R Connor, Peilin Jia, Zhongming Zhao, Scott L Letendre, Ronald J Ellis, William S Bush, David C Samuels, Donald R Franklin, Harpreet Kaur, Jennifer Iudicello, Igor Grant, Asha R Kallianpur
BACKGROUND: HIV-associated neurocognitive disorder (HAND) remains common, despite antiretroviral therapy (ART). HIV dysregulates iron metabolism, but cerebrospinal fluid (CSF) levels of iron and iron-transport proteins in HIV-infected (HIV+) persons are largely unknown. The objectives of this study were to characterize CSF iron-related biomarkers in HIV+ adults and explore their relationships to known predictors of HAND. METHODS: We quantified total iron, transferrin and heavy-chain (H)-ferritin by immunoassay in CSF sampled by lumbar puncture in 403 HIV+ participants in a multi-center, observational study and evaluated biomarker associations with demographic and HIV-related correlates of HAND [e...
April 21, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28426718/effects-of-dietary-beef-pork-chicken-and-salmon-on-intestinal-carcinogenesis-in-a-j-min-mice
#7
Christina Steppeler, Marianne Sødring, Bjørg Egelandsdal, Bente Kirkhus, Marije Oostindjer, Ole Alvseike, Lars Erik Gangsei, Ellen-Margrethe Hovland, Fabrice Pierre, Jan Erik Paulsen
The International Agency for Research on Cancer has classified red meat as "probably carcinogenic to humans" (Group 2A). In mechanistic studies exploring the link between intake of red meat and CRC, heme iron, the pigment of red meat, is proposed to play a central role as a catalyzer of luminal lipid peroxidation and cytotoxicity. In the present work, the novel A/J Min/+ mouse was used to investigate the effects of dietary beef, pork, chicken, or salmon (40% muscle food (dry weight) and 60% powder diet) on Apc-driven intestinal carcinogenesis, from week 3-13 of age...
2017: PloS One
https://www.readbyqxmd.com/read/28418614/efficacy-and-safety-of-low-dose-heparin-in-hemodialysis
#8
Mariana Murea, Gregory B Russell, Pirouz Daeihagh, Anita M Saran, Karan Pandya, Mark Cabrera, John M Burkart, Barry I Freedman
INTRODUCTION: The dose of unfractionated heparin (UFH) administered during hemodialysis (HD) varies widely. This prospective study evaluated the safety and efficacy of UFH dose de-escalation. METHODS: Sixty-six prevalent patients on HD receiving UFH per standard-dose protocol (load dose [LD] 50-75 units/kg, maintenance dose [MD] 500-1000 units/hour) had heparin prescription converted to low-dose protocol (start LD 15 units/kg and MD 500 units/hour; dose adjusted in small increments based on assessments of extracorporeal blood circuit)...
April 18, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28418062/flexible-aspartates-propel-iron-to-the-ferroxidation-sites-along-pathways-stabilized-by-a-conserved-arginine-in-dps-proteins-from-mycobacterium-smegmatis
#9
Sunanda Margrett Williams, Dipankar Chatterji
DNA-binding proteins under starvation (Dps) are dodecameric nano-compartments for iron oxidation and storage in bacterial cells. These proteins have roughly spherical structures with a hollow interior where iron is stored. Through mutational analysis of a conserved arginine residue in the second Dps protein from Mycobacterium smegmatis, we have identified residues which stabilize the interfaces between the iron entry and ferroxidation sites. Also, we have used X-ray crystallography to determine the structures of co-crystals of iron and Dps in varying proportions and compare the changes in these ligand-bound forms with respect to the apo-protein...
April 18, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28415438/development-of-high-efficacy-peptide-coated-iron-oxide-nanoparticles-encapsulated-amphotericin-b-drug-delivery-system-against-visceral-leishmaniasis
#10
Rishikesh Kumar, Krishna Pandey, Ganesh C Sahoo, Susmita Das, Vnr Das, R K Topno, Pradeep Das
Visceral leishmaniasis, a protozoan disease transmitted by phlebotomine sandflies which affect mostly in Indian sub-continent. The treatment for visceral leishmaniasis (VL) caused by Leishmania donovani are limited and unsatisfactory. Currently available drug against such as miltefosine and polymer based drugs amBisome has high efficacy against VL but found serious side effects and poor absorbance. To overcome this, we developed peptide (glycine) coated iron oxide (Fe3O4) nanoparticles (GINPs) encapsulated amphoterecin B (AmB) drug against visceral leishmaniasis...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415402/fattigation-platform-theranostic-nanoparticles-for-cancer-therapy
#11
Thao Truong-Dinh Tran, Phuong Ha-Lien Tran, Tae-Jong Yoon, Beom-Jin Lee
A new conceptual nanoparticle consisting of a silica-coated iron oxide magnetic core and a fattigation-based biocompatible shell with oleic acid and hydrophilic protein (gelatin). The prepared particle can be a useful theranostics platform material for diagnostic imaging and as a drug delivery system. Oleic acid and gelatin were conjugated on the silica-coated magnetic nanoparticle surface to provide three primary functionalities: 1) enhancing biocompatibility and solubility in aqueous solution and providing the ability to incorporate hydrophobic chemical drugs into the shell for delivery, 2) improving treatment-response magnetic monitoring as a diagnostic agent with low nanotoxicity, and 3) increasing anticancer efficacy owing to the controlled release of the incorporated drug in cells and in an animal model...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28412681/research-on-in-vitro-release-of-isoniazid-inh-super-paramagnetic-microspheres-in-different-magnetic-fields
#12
Hongmeng Xie, Hua Huang, Wei He, Zhihong Fu, Cong Luo, Muhmmad Aqeel Ashraf
To explore in vitro release rules of isoniazid (INH) when Isoniazid Super paramagnetic Iron Oxide Microspheres (ISPIOM) are subject to no external magnetic field, applied mechanical magnetic field and scillating magnetic field. ISPIOM was prepared by using the spray drying method; Isoniazid contented in the microspheres was determined, the drug loading capacity and encapsulation efficiency were calculated. Release of isoniazid in the microspheres was determined respectively under the effect of no external magnetic field, applied mechanical magnetic field and oscillating magnetic field, to explore the release rules...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28411639/nanoarmoring-of-enzymes-by-polymer-functionalized-iron-oxide-nanoparticles
#13
Gayan Premaratne, Leslie Coats, Sadagopan Krishnan
Polymer-armored enzymes loaded onto magnetic nanoparticles, as efficient nanobioreactors with enhanced properties, are described in this chapter. Polymers are useful macromolecules carrying a large number of surface charges and repeating units of desired chemical functional groups for linking enzymes onto them. Magnetic micro/nanoparticles have been widely used as enzyme carriers with the incorporation of suitable polymer layers. Synthesized iron oxide magnetic nanoparticles have been used to immobilize a peroxide-catalyzing enzyme-like heme protein: myoglobin using covalent and noncovalent strategies...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28409429/multivariate-statistical-assessment-of-a-polluted-river-under-nitrification-inhibition-in-the-tropics
#14
Thi Thu Huyen Le, Stephanie Zeunert, Malte Lorenz, Günter Meon
A large complex water quality data set of a polluted river, the Tay Ninh River, was evaluated to identify its water quality problems, to assess spatial variation, to determine the main pollution sources, and to detect relationships between parameters. This river is highly polluted with organic substances, nutrients, and total iron. An important problem of the river is the inhibition of the nitrification. For the evaluation, different statistical techniques including cluster analysis (CA), discriminant analysis (DA), and principal component analysis (PCA) were applied...
April 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28405327/iron-overload-correlates-with-serum-liver-fibrotic-markers-and-liver-dysfunction-potential-new-methods-to-predict-iron-overload-related-liver-fibrosis-in-thalassemia-patients
#15
Man Wang, Rongrong Liu, Yuzhen Liang, Gaohui Yang, Yumei Huang, Chunlan Yu, Kaiqi Sun, Yongrong Lai, Yang Xia
BACKGROUND: Early detection of liver fibrosis in thalassemia patients and rapid initiation of treatment to interfere with its progression are extremely important. OBJECTIVE: This study aimed to find a sensitive, easy-to-detect and noninvasive method other than liver biopsy for early detection of liver fibrosis in thalassemia patients. METHODS: A total of 244 Chinese Thalassemia patients with non-transfusion-dependent thalassemia (NTDT, n = 105) or thalassemia major (TM, n = 139) and 120 healthy individuals were recruited into the present study, and blood collagen type IV (C IV), precollagen type III (PIIINPC) and hyaluronic acid (HA), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and ferritin were measured...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28405169/oxidant-induced-autophagy-and-ferritin-degradation-contribute-to-epithelial-mesenchymal-transition-through-lysosomal-iron
#16
Apostolos Sioutas, Linda K Vainikka, Magnus Kentson, Sören Dam-Larsen, Urban Wennerström, Petra Jacobson, Hans Lennart Persson
PURPOSE: Transforming growth factor (TGF)-β1 triggers epithelial-mesenchymal transition (EMT) through autophagy, which is partly driven by reactive oxygen species (ROS). The aim of this study was to determine whether leaking lysosomes and enhanced degradation of H-ferritin could be involved in EMT and whether it could be possible to prevent EMT by iron chelation targeting of the lysosome. MATERIALS AND METHODS: EMT, H-ferritin, and autophagy were evaluated in TGF-β1-stimulated A549 human lung epithelial cells cultured in vitro using Western blotting, with the additional morphological assessment of EMT...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28404645/irp2-as-a-potential-modulator-of-cell-proliferation-apoptosis-and-prognosis-in-nonsmall-cell-lung-cancer
#17
Heena Khiroya, Jasbir S Moore, Nabeel Ahmad, Jamie Kay, Kerry Woolnough, Gerald Langman, Iyad Ismail, Babu Naidu, Chris Tselepis, Alice M Turner
IREB2 is a gene that produces iron regulatory protein 2 (IRP2), which is critical to intracellular iron homeostasis and which relates to the rate of cellular proliferation. IREB2 lies in a lung cancer susceptibility locus. The aims were to assess 1) the relationship between iron loading, cell proliferation and IRP2 expression in lung cancer; 2) the potential of iron related pathways as therapeutic targets; and 3) the relevance of IRP2 in operated lung cancer patients.Cells of two nonsmall cell cancer (NSCLC) lines and primary bronchial epithelial cells (PBECs) were cultured with and without iron; and proliferation, apoptosis and migration were assessed...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28402604/isolated-single-iron-atoms-anchored-on-n-doped-porous-carbon-as-an-efficient-electrocatalyst-for-the-oxygen-reduction-reaction
#18
Yuanjun Chen, Shufang Ji, Yanggang Wang, Juncai Dong, Wenxing Chen, Zhi Li, Rongan Shen, Lirong Zheng, Zhongbin Zhuang, Dingsheng Wang, Yadong Li
The development of low-cost, efficient, and stable electrocatalysts for the oxygen reduction reaction (ORR) is desirable but remains a great challenge. Herein, we made a highly reactive and stable isolated single-atom Fe/N-doped porous carbon (ISA Fe/CN) catalyst with Fe loading up to 2.16 wt %. The catalyst showed excellent ORR performance with a half-wave potential (E1/2 ) of 0.900 V, which outperformed commercial Pt/C and most non-precious-metal catalysts reported to date. Besides exceptionally high kinetic current density (Jk ) of 37...
April 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28399703/value-of-speckle-tracking-echocardiography-for-detection-of-clinically-silent-left-ventricular-dysfunction-in-patients-with-%C3%AE-thalassemia
#19
Mozhgan Parsaee, Sedigheh Saedi, Pegah Joghataei, Azita Azarkeivan, Zahra Alizadeh Sani
OBJECTIVE: β-Thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia requiring chronic transfusion therapy. Cardiac involvement is the main cause of death in patients with thalassemia major. The narrow border is between overt myocardial dysfunction and clinically silent left ventricular (LV) dysfunction in patients with thalassemia. Therefore, we need novel parameters in different imaging techniques to discover cardiac involvement in an early and subtle stage...
April 12, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28399482/functionalized-polymer-iron-oxide-hybrid-nanofibers-electrospun-filtration-devices-for-metal-oxyanion-removal
#20
Katherine T Peter, Adam J Johns, Nosang V Myung, David M Cwiertny
Via a single-pot electrospinning synthesis, we developed a functionalized polymer-metal oxide nanofiber filter for point of use (POU) water treatment of metal oxyanions (e.g., arsenate and chromate). Polyacrylonitrile (PAN) functionalization was accomplished by inclusion of surface-active, quaternary ammonium salts (QAS) [cetyltrimethylammonium bromide (CTAB) or tetrabutylammonium bromide (TBAB)] that provide strong base ion exchange sites. Embedded iron oxide [ferrihydrite (Fh)] nanoparticles were used for their established role as metal sorbents...
April 4, 2017: Water Research
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