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Iron loading

Eduardo Guisasola, Laura Asín, Lillianne Beola, Jesús M De La Fuente, Alejandro Baeza, María Vallet Regí
This work presents an innovation in the tumor treatment in vivo mediated by magnetic mesoporous silica nanoparticles (MMSNs). This device was built with iron oxide magnetic nanoparticles embedded in a mesoporous silica matrix and coated with an engineered thermoresponsive polymer. The magnetic nanoparticles act as internal heating sources under an alternating magnetic field (AMF) that increase the temperature of the surroundings, provoking the polymer transition and consequently the release of a drug trapped inside the silica pores...
March 21, 2018: ACS Applied Materials & Interfaces
Yi Zhang, Jielin Pan, Qilan Xu, Hao Li, Jianhao Wang, Chao Zhang, Guobin Hong
Objective: To construct carcinoma vascular endothelial-targeted polymeric nanomicelles with high magnetic resonance imaging (MRI) sensitivity and to evaluate their biological safety and in vitro tumor-targeting effect, and to monitor their feasibility using clinical MRI scanner. Method: Amphiphilic block copolymer, poly(ethylene glycol)- b -poly(ε-caprolactone) (PEG-PCL) was synthesized via the ring-opening polymerization of ε-caprolactone (CL) initiated by poly(ethylene glycol) (PEG), in which cyclic pentapeptide Arg-Gly-Asp (cRGD) was conjugated with the terminal of hydrophilic PEG block...
2018: International Journal of Medical Sciences
Aziza Hadj Ltaïef, Simona Sabatino, Federica Proietto, Salah Ammar, Abdellatif Gadri, Alessandro Galia, Onofrio Scialdone
The treatment of toxic organic pollutants by electro-Fenton (EF) presents some drawbacks such as the necessity to work at low pH and the low solubility of oxygen in water contacted with air or oxygen at room pressure that results often in slow and relatively low abatements. Here, the coupled adoption of natural heterogeneous catalysts and of relatively high pressure was proposed in order to improve the performances of EF for the treatment of organic pollutants. Caffeic acid (CA) and 3-chlorophenol were used as model resistant organic pollutants...
March 12, 2018: Chemosphere
Antonio Layoun, Macha Samba-Mondonga, Gabriela Fragoso, Annie Calvé, Manuela M Santos
Iron homeostasis is tightly regulated to provide virtually all cells in the body, particularly red blood cells, with this essential element while defending against its toxicity. The peptide hormone hepcidin is central to the control of the amount of iron absorbed from the diet and iron recycling from macrophages. Previously, we have shown that hepcidin induction in macrophages following Toll-like receptor (TLR) stimulation depends on the presence of myeloid differentiation primary response gene 88 (MyD88). In this study, we analyzed the regulation of iron metabolism in MyD88 -/- mice to further investigate MyD88 involvement in iron sensing and hepcidin induction...
2018: Frontiers in Physiology
Anna J Komor, Andrew J Jasniewski, Lawrence Que, John D Lipscomb
Covering: up to 2017The participation of non-heme dinuclear iron cluster-containing monooxygenases in natural product biosynthetic pathways has been recognized only recently. At present, two families have been discovered. The archetypal member of the first family, CmlA, catalyzes β-hydroxylation of l-p-aminophenylalanine (l-PAPA) covalently linked to the nonribosomal peptide synthetase (NRPS) CmlP, thereby effecting the first step in the biosynthesis of chloramphenicol by Streptomyces venezuelae. CmlA houses the diiron cluster in a metallo-β-lactamase protein fold instead of the 4-helix bundle fold of nearly every other diiron monooxygenase...
March 19, 2018: Natural Product Reports
Stefanie Klein, Marc Wegmann, Luitpold V R Distel, Winfried Neuhuber, Carola Kryschi
Silicon nanoparticles with sizes between were synthesized through wet-chemistry procedures using diverse phase transfer reagents. On the other hand, the preparation of iron-doped silicon nanoparticles was carried out using the precursor Na4 Si4 containing 5% Fe. Biocompatibility of all silicon nanoparticle samples was achieved by surface-stabilizing with (3-aminopropyl)triethoxysilane. These surface structures provided positive surface charges which facilitated electrostatic binding to the negatively charged biological membranes...
March 15, 2018: Biochemical and Biophysical Research Communications
J M G van Bergen, X Li, F C Quevenco, A F Gietl, V Treyer, R Meyer, A Buck, P A Kaufmann, R M Nitsch, P C M van Zijl, C Hock, P G Unschuld
The accumulation of β-amyloid plaques is a hallmark of Alzheimer's disease (AD), and recently published data suggest that increased brain iron burden may reflect pathologies that synergistically contribute to the development of cognitive dysfunction. While preclinical disease stages are considered most promising for therapeutic intervention, the link between emerging AD-pathology and earliest clinical symptoms remains largely unclear. In the current study we therefore investigated local correlations between iron and β-amyloid plaques, and their possible association with cognitive performance in healthy older adults...
March 13, 2018: NeuroImage
Juan Xiong, Meihua Hu, Xiaoping Li, Hongying Li, Xin Li, Xiang Liu, Guozhong Cao, Weishan Li
A porous graphite (PG) is proposed as anode electrocatalyst of microbial fuel cell (MFC), which is synthesized by thermally decomposing ferrous gluconate followed by leaching iron. The physical characterizations from scanning electron microscopy, Brunauer-Emmett-Teller, X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy, indicate that the resulting PG is mesopore-rich and exhibits high graphitization with oxygen-containing functional groups...
March 5, 2018: Biosensors & Bioelectronics
Kuikun Yang, Yijing Liu, Yi Liu, Qian Zhang, Chuncai Kong, Chenglin Yi, Zijian Zhou, Zhantong Wang, Guofeng Zhang, Yang Zhang, Niveen M Khashab, Xiaoyuan Chen, Zhihong Nie
This article describes the fabrication of nanosized magneto-vesicles (MVs) comprising tunable layers of densely-packed superparamagnetic iron oxide nanoparticles (SPIONs) in membranes via cooperative assembly of polymer-tethered SPIONs and free poly(styrene)-b-poly(acrylic acid) (PS-b-PAA). The membrane thickness of MVs could be well controlled from 9.8 to 93.2 nm by varying the weight ratio of PS-b-PAA to SPIONs. The increase in membrane thickness was accompanied with the transition from monolayer MVs, to double-layered MVs and to multilayered MVs (MuMVs)...
March 15, 2018: Journal of the American Chemical Society
E Millart, S Lesieur, V Faivre
Introduction The development of multifunctional drug carriers provides many opportunities in the field of drug delivery. Among them, carriers loaded with both drug and superparamagnetic iron oxide nanoparticles would allow the combination of chemotherapy with the possibility of monitoring or controlling the distribution of the nanocarrier in the body, triggering drug release and/or applying a synergistic hyperthermia treatment. Areas covered The present review covers biocompatible lipid-based nanotechnologies that have been employed to co-encapsulate drug and iron oxide...
March 15, 2018: Expert Opinion on Drug Delivery
Omkara Swami Muddineti, Preeti Kumari, Balaram Ghosh, Swati Biswas
PURPOSE: Transferrin receptor (TfR) is up-regulated in various malignant tumors not only to meet the iron requirement, but also to increase the cell survival via participation in various cellular signaling pathways. Here we explored transferrin as ligand for Poly(ethylene Glycol) (PEG)-ylated vitamin-E/lipid (PE) core micelles (VPM). METHODS: Transferrin modified polymer was synthesized and drug loaded micelles were evaluated in 2D Hela and HepG2 cancer cells for cellular uptake and cytotoxicity and in 3D Hela spheroids for growth inhibition, uptake and penetration studies...
March 14, 2018: Pharmaceutical Research
Martin Drost, Fan Tu, Luisa Berger, Christian Preischl, Wencai Zhou, Hartmut Gliemann, Christof Wöll, Hubertus Marbach
We demonstrate that Surface-Anchored Metal-Organic Frameworks (SURMOFs) are extraordinary well-suited as resists for high-resolution Focused Electron Beam Induced Processing (FEBIP) techniques. The combination of such powerful lithographic protocols with the huge versatility of MOF materials are investigated in respect to their potential in nanostructures fabrication. The applied FEBIP methods rely on the local decomposition of Fe(CO)5 and Co(CO)3 NO as precursors, either by the direct impact of the focused electron beam (Electron Beam Induced Deposition, EBID) or through the interaction of the precursor molecules with preirradiated/activated SURMOF areas (Electron Beam Induced Surface Activation, EBISA)...
March 14, 2018: ACS Nano
Verónica Poza-Nogueiras, Emilio Rosales, Marta Pazos, M Ángeles Sanromán
Over the last decades, advanced oxidation processes have often been used alone, or combined with other techniques, for remediation of ground and surface water pollutants. The application of heterogeneous catalysis to electrochemical advanced oxidation processes is especially useful due to its efficiency and environmental safety. Among those processes, electro-Fenton stands out as the one in which heterogeneous catalysis has been broadly applied. Thus, this review has introduced an up-to-date collation of the current knowledge of the heterogeneous electro-Fenton process, highlighting recent advances in the use of different catalysts such as iron minerals (pyrite, magnetite or goethite), prepared catalysts by the load of metals in inorganic and organic materials, nanoparticles, and the inclusion of catalysts on the cathode...
March 2, 2018: Chemosphere
Mounika Kodali, Sergio Herrera, Sadia Kabir, Alexey Serov, Carlo Santoro, Ioannis Ieropoulos, Plamen Atanassov
Iron aminoantipyrine (Fe-AAPyr), graphene nanosheets (GNSs) derived catalysts and their physical mixture Fe-AAPyr-GNS were synthesized and investigated as cathode catalysts for oxygen reduction reaction (ORR) with the activated carbon (AC) as a baseline. Fe-AAPyr catalyst was prepared by Sacrificial Support Method (SSM) with silica as a template and aminoantipyrine (AAPyr) as the organic precursor. 3D-GNS was prepared using modified Hummers method technique. The Oxygen Reduction Reaction (ORR) activity of these catalysts at different loadings was investigated by using rotating ring disk (RRDE) electrode setup in the neutral electrolyte...
March 1, 2018: Electrochimica Acta
Benjamin D Fellows, Nardine Ghobrial, Elliot Mappus, Andrew Hargett, Mark Bolding, Delphine Dean, Olin Thompson Mefford
Restenosis by neointimal hyperplasia is still an ongoing concern in endovascular surgery. Slowing vascular smooth muscle cell (VSMC) proliferation by reversing the phenotype change, would allow vessel healing and re-endotheliazation. To accomplish this, we have developed heparin-coated magnetic nanoparticles for targeted drug therapy of neointimal hyperplasia. Iron oxide nanoparticles were modified with a poly (ethylene oxide) based coating and then further functionalized with heparin. In vitro experiments were conducted to observe changes in phenotype, metabolic activity, and viability of three relevant cell lines including VSMC, endothelial cells and fibroblasts...
March 8, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Akhila Jose, Mrudula Surendran, Sajid Fazal, Bindhu-Paul Prasanth, Deepthy Menon
This work reports the potential of iron quantum clusters (FeQCs) as a hyperthermia agent for cancer, by testing its in-vitro response to shortwave (MHz range), radiofrequency (RF) waves non-invasively. Stable, fluorescent FeQCs of size ∼1 nm prepared by facile aqueous chemistry from endogenous protein haemoglobin were found to give a high thermal response, with a ΔT ∼50 °C at concentrationsas low as165 μg/mL. The as-prepared nanoclusters purified by lyophilization as well as dialysis showed a concentration, power and time-dependent RF response, with the lyophilized FeQCs exhibiting pronounced heating effects...
February 27, 2018: Colloids and Surfaces. B, Biointerfaces
Péter Veres, Dániel Sebők, Imre Dékány, Pavel Gurikov, Irina Smirnova, István Fábián, József Kalmár
Iron(III)-crosslinked alginate aerogel beads (d = 3-5 mm) were prepared and loaded with ibuprofen by using the technique of adsorptive deposition from supercritical CO2 . Additional formulations were prepared where the aerogels were co-impregnated by ibuprofen and ascorbic acid. The release of ibuprofen from the Fe(III)-alginate is much faster in pH = 7.4 (PBS) than in pH = 2.0 (HCl), which can be explained by the faster dissolution and higher swelling of the alginate matrix in PBS. By decreasing the size of the beads and using a higher G content alginate the release rate could be slightly increased...
May 15, 2018: Carbohydrate Polymers
Lan Liu, Baoji Du, Changshuai Shang, Jin Wang, Erkang Wang
Hybrid nanomaterials with synergistic effect are highly potential for developing advanced nanozymes. Herein, we designed a nanozyme assembled by polyethylenimine (PEI)-protected reduced graphene oxide anchoring iron oxide (PRGI) and Pt nanoparticle using electrostatic interaction, PRGI/Pt nanohybrid. The different ratio of PRGI nanocomposite and Pt nanoparticle could control PRGI/Pt nanohybrid's surface charge and stability, which determined PRGI/Pt nanohybrid's catalytic activity. At the mass ratio of 0.8, the as-obtained PRGI/Pt nanohybrid showed the highest catalytic ability, and was better than Pt nanoparticle at different pH and temperature, although the PRGI/Pt nanohybrid showed lower affinity for TMB than Pt nanoparticle, which maybe attributed to the fact that PRGI/Pt nanohybrid possessed better product desorption ability or larger contact area...
July 19, 2018: Analytica Chimica Acta
Fan Yang, Johnson Efome, Dipak Rana, Takeshi Matsuura, Christopher Lan
Among other applications, metal-organic frameworks (MOFs) are slowly gaining grounds as fillers for desalination composite membranes. In this study, superhydrophobic poly (vinylidene fluoride) (PVDF) nanofibrous membranes were fabricated with MOF (Iron-BTC) loading of up to 5 wt.% via electro-spinning on a nonwoven substrate. To improve attachment of nanofibers unto the substrate, a substrate pre-treatment method called 'solvent basing' was employed. Iron content in the nanofiber, measured by dispersive X-ray spectroscopy (EDS), increased proportionally with the increase of MOF concentration in the spinning dope, indicating a uniform distribution of MOF in the nanofiber...
March 8, 2018: ACS Applied Materials & Interfaces
Huimin Lin, Caixia Fu, Stephan Kannengiesser, Shu Cheng, Jun Shen, Haipeng Dong, Fuhua Yan
BACKGROUND: The coexistence of hepatic iron and fat is common in patients with hyperferritinemia, which plays an interactive and aggressive role in the progression of diseases (fibrosis, cirrhosis, and hepatocellular carcinomas). PURPOSE: To evaluate a modified high-speed T2 -corrected multi-echo, single voxel spectroscopy sequence (HISTOV) for liver iron concentration (LIC) quantification in patients with hyperferritinemia, with simultaneous fat fraction (FF) estimation...
March 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
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