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https://www.readbyqxmd.com/read/28338491/perioperative-management-of-blood-loss-in-spine-surgery
#1
Rabia Qureshi, Varun Puvanesarajah, Amit Jain, Hamid Hassanzadeh
Spine procedures are associated with high rates of blood loss which can result in a greater need for transfusions. Repeated exposure to blood products is associated with risks and adverse reactions such as transfusion-related acute lung injury, fluid shifting, and infections. With the higher number of spine procedures and the increasing open surgery times associated with difficult procedures, excessive blood loss has become more prevalent. Perioperative methods have been established to combat the excessive blood loss and decrease the need for blood products...
March 23, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28336375/tumortropic-adipose-derived-stem-cells-carrying-smart-nanotherapeutics-for-targeted-delivery-and-dual-modality-therapy-of-orthotopic-glioblastoma
#2
Wen-Chia Huang, I-Lin Lu, Wen-Hsuan Chiang, Yi-Wen Lin, Yuan-Chung Tsai, Hsin-Hung Chen, Chien-Wen Chang, Chi-Shiun Chiang, Hsin-Cheng Chiu
Chemotherapy is typically used to treat malignant brain tumors, especially for the tumors in surgically inaccessible areas. However, owing to the existence of blood-brain barrier (BBB), the tumor accumulation and therapeutic efficacy of clinical therapeutics is still of great concerns. To this end, we present herein a prominent therapeutic strategy adopting adipose-derived stem cells (ADSCs) capable of carrying nanotherapeutic payloads selectively toward brain tumors for thermo/chemotherapy. The nanoparticle (NP) payload was obtained from co-assembly of poly(γ-glutamic acid-co-distearyl γ-glutamate) with poly(lactic-co-glycolic acid), paclitaxel (PTX), and oleic acid-coated superparamagnetic iron oxide NPs in aqueous solution...
March 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28332409/laboratory-and-pilot-scale-field-experiments-for-application-of-iron-oxide-nanoparticle-loaded-chitosan-composites-to-phosphate-removal-from-natural-water
#3
Jae-Hyun Kim, Song-Bae Kim, Sang-Hyup Lee, Jae-Woo Choi
The aim of this study was to apply iron oxide nanoparticle-chitosan (ION-chitosan) composites to phosphate removal from natural water collected from the Seoho Stream in Suwon, Republic of Korea. Laboratory batch experiments showed that phosphate removal by the ION-chitosan composites was not sensitive to pH changes between pH values of 5.0 and 9.0. During six cycles of adsorption-desorption, the composites could be successfully regenerated with 5 mM NaOH solution and reused for phosphate removal. Laboratory fixed-bed column experiments (column height = 10 and 20 cm, inner diameter = 2...
March 23, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28332093/pathogenic-implications-of-distinct-patterns-of-iron-and-zinc-in-chronic-ms-lesions
#4
Bogdan F Popescu, Josa M Frischer, Samuel M Webb, Mylyne Tham, Reginald C Adiele, Christopher A Robinson, Patrick D Fitz-Gibbon, Stephen D Weigand, Imke Metz, Susan Nehzati, Graham N George, Ingrid J Pickering, Wolfgang Brück, Simon Hametner, Hans Lassmann, Joseph E Parisi, Guo Yong, Claudia F Lucchinetti
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) in which oligodendrocytes, the CNS cells that stain most robustly for iron and myelin are the targets of injury. Metals are essential for normal CNS functioning, and metal imbalances have been linked to demyelination and neurodegeneration. Using a multidisciplinary approach involving synchrotron techniques, iron histochemistry and immunohistochemistry, we compared the distribution and quantification of iron and zinc in MS lesions to the surrounding normal appearing and periplaque white matter, and assessed the involvement of these metals in MS lesion pathogenesis...
March 22, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28330763/ph-responsive-controlled-release-of-anti-cancer-hydrophobic-drugs-from-sodium-alginate-and-hydroxyapatite-bi-coated-iron-oxide-nanoparticles
#5
Danushika C Manatunga, Rohini M de Silva, K M Nalin de Silva, Nuwan de Silva, Shiva Bhandari, Yoke Khin Yap, N Pabakara Costha
Developing a drug carrier system which could perform targeted and controlled release over a period of time is utmost concern in the pharmaceutical industry. This is more relevant when designing drug carriers for poorly water soluble drug molecules such as curcumin and 6-gingerol. Development of a drug carrier system which could overcome these limitations and perform controlled and targeted drug delivery is beneficial. This study describes a promising approach for the design of novel pH sensitive sodium alginate, hydroxyapatite bilayer coated iron oxide nanoparticle composite (IONP/HAp-NaAlg) via the co-precipitation approach...
March 18, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28320041/prevention-of-iron-overload-and-long-term-maintenance-of-normal-iron-stores-in-thalassaemia-major-patients-using-deferiprone-or-deferiprone-deferoxamine-combination
#6
Annita Kolnagou, Christina N Kontoghiorghe, George J Kontoghiorghes
Decrease in mortality and morbidity is observed in thalassaemia major patients with reduced iron load in comparison to heavy iron loaded patients. Effective and complete treatment of transfusional iron overload can be achieved by chelation protocols that can eliminate excess iron and maintain normal iron stores (NIS). The maintenance of NIS, i. e., serum ferritin (350 μg/L >), MRI T2* cardiac (>20 ms) and liver (>6.3 ms) relaxation time levels was monitored in 16 thalassaemia major patients (32-53 years, 12 splenectomized, 10 male, erythrocyte transfusions 120-323 ml/kg/year) for about 90 patient years...
March 20, 2017: Drug Research
https://www.readbyqxmd.com/read/28318691/evaluation-of-simulated-dredging-to-control-internal-phosphorus-release-from-sediments-focused-on-phosphorus-transfer-and-resupply-across-the-sediment-water-interface
#7
Juhua Yu, Shiming Ding, Jicheng Zhong, Chengxin Fan, Qiuwen Chen, Hongbin Yin, Lei Zhang, Yinlong Zhang
Sediment dredging is an effective restoration method to control the internal phosphorus (P) loading of eutrophic lakes. However, the core question is that the real mechanism of dredging responsible for sediment internal P release still remains unclear. In this study, we investigated the P exchange across the sediment-water interface (SWI) and the internal P resupply ability from the sediments after dredging. The study is based on a one-year field simulation study in Lake Taihu, China, using a Rhizon soil moisture sampler, high-resolution dialysis (HR-Peeper), ZrO-Chelex diffusive gradients in thin film (ZrO-Chelex DGT), and P fractionation and adsorption isotherm techniques...
March 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28293962/effects-of-different-iron-supply-to-pregnant-sows-sus-scrofa-domestica-l-on-reproductive-performance-as-well-as-iron-status-of-new-born-piglets
#8
Marzell Buffler, Christiane Becker, Wilhelm M Windisch
The present study aimed to investigate the effects of different iron (Fe) supply to sows during gestation on their reproductive performance and placental Fe load. Additionally, the Fe status of the corresponding offspring was assessed. Twenty multiparous sows were fed from insemination to farrowing with isoenergetic and isonitrogenic balanced diets differing in Fe content. The diet low in Fe (Group -Fe) was mainly composed of soybean meal and maize meal and had a Fe content of 114 mg/kg DM. For the diet high in Fe (Group +Fe), the diet was supplemented with Fe(II)SO4 · 7H2O to a total Fe content of 256 mg/kg...
March 15, 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28293818/the-effect-of-frequency-of-c-e-r-a-administration-on-the-contribution-of-dietary-iron-for-erythropoiesis
#9
Yukari Matsuo-Tezuka, Mariko Noguchi-Sasaki, Mitsue Kurasawa, Keigo Yorozu, Yasushi Shimonaka
Erythropoiesis-stimulating agents are among the therapeutic options for renal anemia. Under erythropoietic stimulation, the synthesis of hemoglobin requires a large amount of iron, which is supplied both from absorption of dietary iron and the mobilization of stored iron. However, under iron-loading conditions, dietary iron absorption is suppressed via down-regulation of duodenal iron transporters. Because the contribution of dietary iron is essential for erythropoiesis, we aimed to investigate the conditions in which dietary iron is efficiently used for erythropoiesis...
March 14, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28292181/synthesis-structure-characterization-and-evaluation-in-microglia-cultures-of-neuromelanin-analogues-suitable-for-modeling-parkinson-s-disease
#10
Emanuele Ferrari, Andrea Capucciati, Ilaria Prada, Fabio Andrea Zucca, Giulia D'Arrigo, Daniele Pontiroli, Maria Grazia Bridelli, Michela Sturini, Luigi Bubacco, Enrico Monzani, Claudia Verderio, Luigi Zecca, Luigi Casella
In the substantia nigra of human brain, neuromelanin (NM) released by degenerating neurons can activate microglia with consequent neurodegeneration, typical of Parkinson's disease (PD). Synthetic analogues of NM were prepared to develop a PD model reproducing the neuropathological conditions of the disease. Soluble melanin-protein conjugates were obtained by melanization of fibrillated β-lactoglobulin (fLG). The melanic portion of the conjugates contains either eumelanic (EufLG) or mixed eumelanic/pheomelanic composition (PheofLG), the latter better simulating natural NMs...
March 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28290964/anabolic-adaptations-occur-in-conscripts-during-basic-military-training-despite-high-prevalence-of-vitamin-d-deficiency-and-decrease-in-iron-status
#11
Vahur Ööpik, Saima Timpmann, Leho Rips, Indrek Olveti, Kersti Kõiv, Martin Mooses, Hanno Mölder, Ahti Varblane, Hele-Reet Lille, Helena Gapeyeva
INTRODUCTION: In Estonian Defense Forces that are drawn up on the basis of the conscription model considerable numbers of young men are prematurely discharged from military service for medical reasons, but causes leading to premature dropout of conscripts have not been systematically studied. However, one of the factors involved could be relatively demanding physical training that starts at the beginning of military service in the form of basic military training (BMT). Cumulative training and nontraining stresses experienced by conscripts during BMT may exceed their physiological adaptability and increase the probability of becoming prematurely discharged...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28286877/il-22-controls-iron-dependent-nutritional-immunity-against-systemic-bacterial-infections
#12
Kei Sakamoto, Yun-Gi Kim, Hideki Hara, Nobuhiko Kamada, Gustavo Caballero-Flores, Emanuela Tolosano, Miguel P Soares, José L Puente, Naohiro Inohara, Gabriel Núñez
Host immunity limits iron availability to pathogenic bacteria, but whether immunity limits pathogenic bacteria from accessing host heme, the major source of iron in the body, remains unclear. Using Citrobacter rodentium, a mouse enteric pathogen and Escherichia coli, a major cause of sepsis in humans as models, we find that interleukin-22, a cytokine best known for its ability to promote epithelial barrier function, also suppresses the systemic growth of bacteria by limiting iron availability to the pathogen...
February 2017: Science Immunology
https://www.readbyqxmd.com/read/28285157/near-infrared-light-responsive-nanoparticles-with-thermosensitive-yolk-shell-structure-for-multimodal-imaging-and-chemo-photothermal-therapy-of-tumor
#13
Song Shen, Bei Ding, Shengchang Zhang, Xueyong Qi, Kun Wang, Jie Tian, Yongsheng Yan, Yanru Ge, Lin Wu
Thermosensitive yolk-shell nanoparticles were developed as remote-controlled targeting drug delivery platform for multimodal imaging and combined therapy of cancer. The nanoparticles were fabricated using magnetic Fe3O4 nanoparticles as photothermal cores, thermo-responsive poly(N-isopropylacrylamide)-co-1-Vinyl-2-pyrrolidone p(NIPAM-co-NVP) as shells (Fe3O4-PNIPAM), with a hollow space between the two layers for loading of chemotherapeutic drug. The magnetic iron oxide nanoparticles cores could absorb and transform light to heat efficiently upon the irradiation of near infrared (NIR) laser, resulting in the shrink of the PNIPAM shell and the release of chemo-drugs...
March 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28284604/identification-of-the-ferric-iron-utilization-gene-b739_1208-and-its-role-in-the-virulence-of-r-anatipestifer-ch-1
#14
MengYi Wang, PengYun Zhang, DeKang Zhu, MingShu Wang, RenYong Jia, Shun Chen, KunFeng Sun, Qiao Yang, Ying Wu, XiaoYue Chen, Francis Biville, AnChun Cheng, MaFeng Liu
Riemerella anatipestifer is an important bacterial pathogen in ducks and causes heavy economic losses in the duck industry. However, the pathogensis of this bacterium is poorly understood. In this study, a putative outer membrane hemin receptor gene B739_1208 in R. anatipestifer CH-1 was deleted to determine the relationship between iron uptake and virulence. The R. anatipestifer CH-1ΔB739_1208 mutants grew significantly more slowly than the wild-type bacteria in TSB liquid medium. Further characterization revealed that the R...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28278781/phytoremediation-potential-of-water-caltrop-trapa-natans-l-using-municipal-wastewater-of-the-activated-sludge-process-based-municipal-wastewater-treatment-plant
#15
Vinod Kumar, A K Chopra
Phytoremediation experiments were carried out to assess the phytoremediation potential of water caltrop (Trapa natans L.) using municipal wastewater collected from the activated sludge process- (ASP) based municipal wastewater treatment plant. The results revealed that T. natans significantly (P ≤ .05/P ≤ .01/P ≤ .001) reduced the contents of total dissolved solids (TDS), electrical conductivity (EC), biochemical oxygen demand (BOD5), chemical oxygen demand, total Kjeldahl nitrogen, phosphate ([Formula: see text]), sodium (Na(+)), potassium (K(+)), calcium (Ca(2+)), magnesium (Mg(2+)), cadmium (Cd), chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), lead (Pb), zinc (Zn), standard plate count, and most probable number of the municipal wastewater after phytoremediation experiments...
February 22, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28278089/integrating-fenton-s-process-and-ion-exchange-for-olive-mill-wastewater-treatment-and-iron-recovery
#16
Patrícia M Reis, Pedro J M Marques, Rui C Martins, Licínio M Gando-Ferreira, Rosa M Quinta-Ferreira
A novel integrated methodology involving Fenton's process followed by ion exchange was proposed for the treatment of olive mill wastewater. The Fenton's process was optimized and it was able to remove up to 81% of COD when pH 3.5, reaction time 1h, [Fe(2+)] = 50 mg.L(-1) and [Fe(2+)]/[H2O2] = 0.002 were applied. In spite of the potential of this treatment approach, final iron removal from the liquid typically entails pH increase and iron sludge production. The integration of an ion exchange procedure using Lewatit TP 207 resin revealed to be able to overcome this important environmental shortcoming...
March 1, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28274767/copper-sulfide-nanoparticle-based-localized-drug-delivery-system-as-an-effective-cancer-synergistic-treatment-and-theranostic-platform
#17
Lin Hou, Xiaoning Shan, Lisha Hao, Qianhua Feng, Zhenzhong Zhang
Localized cancer treatment with combination therapy has attracted increasing attention for effective inhibition of tumor growth. In this work, we introduced diffusion molecular retention (DMR) tumor targeting effect, a new strategy that employed transferrin (Tf) modified hollow mesoporous CuS nanoparticles (HMCuS NPs) to undergo extensive diffuse through the interstitium and tumor retention after a peritumoral (PT) injection. Herein, HMCuS NPs with strong near-infrared (NIR) absorption and photothermal conversion efficiency could serve as not only a drug carrier but also a powerful contrast agent for photoacoustic imaging to guide chemo-phototherapy...
March 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28273330/interventions-for-hereditary-haemochromatosis-an-attempted-network-meta-analysis
#18
REVIEW
Elena Buzzetti, Maria Kalafateli, Douglas Thorburn, Brian R Davidson, Emmanuel Tsochatzis, Kurinchi Selvan Gurusamy
BACKGROUND: Hereditary haemochromatosis is a genetic disorder related to proteins involved in iron transport, resulting in iron load and deposition of iron in various tissues of the body. This iron overload leads to complications including liver cirrhosis (and related complications such as liver failure and hepatocellular carcinoma), cardiac failure, cardiac arrhythmias, impotence, diabetes, arthritis, and skin pigmentation. Phlebotomy (venesection or 'blood letting') is the currently recommended treatment for hereditary haemochromatosis...
March 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28262797/low-crystalline-iron-oxide-hydroxide-nanoparticle-anode-for-high-performance-supercapacitors
#19
Kwadwo Asare Owusu, Longbing Qu, Jiantao Li, Zhaoyang Wang, Kangning Zhao, Chao Yang, Kalele Mulonda Hercule, Chao Lin, Changwei Shi, Qiulong Wei, Liang Zhou, Liqiang Mai
Carbon materials are generally preferred as anodes in supercapacitors; however, their low capacitance limits the attained energy density of supercapacitor devices with aqueous electrolytes. Here, we report a low-crystalline iron oxide hydroxide nanoparticle anode with comprehensive electrochemical performance at a wide potential window. The iron oxide hydroxide nanoparticles present capacitances of 1,066 and 716 F g(-1) at mass loadings of 1.6 and 9.1 mg cm(-2), respectively, a rate capability with 74...
March 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28257520/lactoferrin-binding-protein-b-a-bi-functional-bacterial-receptor-protein
#20
Nicholas K H Ostan, Rong-Hua Yu, Dixon Ng, Christine Chieh-Lin Lai, Anastassia K Pogoutse, Vladimir Sarpe, Morgan Hepburn, Joey Sheff, Shaunak Raval, David C Schriemer, Trevor F Moraes, Anthony B Schryvers
Lactoferrin binding protein B (LbpB) is a bi-lobed outer membrane-bound lipoprotein that comprises part of the lactoferrin (Lf) receptor complex in Neisseria meningitidis and other Gram-negative pathogens. Recent studies have demonstrated that LbpB plays a role in protecting the bacteria from cationic antimicrobial peptides due to large regions rich in anionic residues in the C-terminal lobe. Relative to its homolog, transferrin-binding protein B (TbpB), there currently is little evidence for its role in iron acquisition and relatively little structural and biophysical information on its interaction with Lf...
March 2017: PLoS Pathogens
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