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Infectious disease dynamics

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https://www.readbyqxmd.com/read/28323070/urbanization-and-the-dynamics-of-rna-viruses-in-mallards-anas-platyrhynchos
#1
Michelle Wille, Kristine Lindqvist, Shaman Muradrasoli, Björn Olsen, Josef D Järhult
Urbanization is intensifying worldwide, and affects the epidemiology of infectious diseases. However, the effect of urbanization on natural host-pathogen systems remains poorly understood. Urban ducks occupy an interesting niche in that they directly interact with both humans and wild migratory birds, and either directly or indirectly with food production birds. Here we have collected samples from Mallards residing in a pond in central Uppsala, Sweden, from January 2013 to January 2014. This artificial pond is kept ice-free during the winter months, and is a popular location where the ducks are fed, resulting in a resident population of ducks year-round...
March 17, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28317799/a-first-insight-into-the-genetic-diversity-of-mycobacterium-tuberculosis-in-veracruz-mexico
#2
Raquel Almaraz-Velasco, Daniela Munro-Rojas, Javier Fuentes-Domínguez, Raquel Muñiz-Salazar, Maria Angélica Ibarra-Estela, Alma Delia Guevara-Méndez, Rosa Icela Chaparro-Martinez, Monserrat Perez-Navarro, Roberto Zenteno-Cuevas
OBJECTIVE/BACKGROUND: Tuberculosis (TB) remains one of the most important infectious diseases. Although Mexico is one of the Latin American countries with the largest contribution to these statistics, there are few reports that describe the genotypic characteristics of TB. The aim of this study was to use the MIRU-VNTR-24 loci to analyze the genetic diversity of M. tuberculosis circulating in the state of Veracruz, Mexico. METHODS: Here, we analyze by MIRU-VNTR-24 loci 80 clinical isolates from individuals with confirmed TB from Veracruz México, also clinical and epidemiological variables were recovered and analyzed...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28306733/hypervirulent-mycobacterium-tuberculosis-strain-triggers-necrotic-lung-pathology-associated-with-enhanced-recruitment-of-neutrophils-in-resistant-c57bl-6-mice
#3
Fabrício M Almeida, Thatiana L B Ventura, Eduardo P Amaral, Simone C M Ribeiro, Sanderson D Calixto, Marcelle R Manhães, Andreza L Rezende, Giliane S Souzal, Igor S de Carvalho, Elisangela C Silva, Juliana Azevedo da Silva, Eulógio C Q Carvalho, Afranio L Kritski, Elena B Lasunskaia
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb) that in most cases induces irreversible necrosis of lung tissue as a result of excessive inflammatory reactions. The murine model of TB in resistant C57BL/6 mice infected with reference Mtb strains is widely used in TB studies; however, these mice do not show a necrotic pathology, which restricts their use in studies of irreversible tissue damage. Recently, we demonstrated that necrotic lung lesions could be induced in the C57BL/6 mice by highly virulent Mtb strains belonging to the modern Beijing sublineage...
2017: PloS One
https://www.readbyqxmd.com/read/28304356/spatially-correlated-time-series-and-ecological-niche-analysis-of-cutaneous-leishmaniasis-in-afghanistan
#4
Oyelola A Adegboye, Majeed Adegboye
Leishmaniasis is the third most common vector-borne disease and a very important protozoan infection. Cutaneous leishmaniasis is one of the most common types of leishmaniasis infectious diseases with up to 1.2 million occurrences of new cases each year worldwide. A dynamic transmission multivariate time series model was applied to the data to account for overdispersion and evaluate the effects of three environmental layers as well as seasonality in the data. Furthermore, ecological niche modeling was used to study the geographically suitable conditions for cutaneous leishmaniasis using temperature, precipitation and altitude as environmental layers, together with the leishmaniasis presence data...
March 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28303104/mathematical-modeling-of-streptococcus-pneumoniae-colonization-invasive-infection-and-treatment
#5
Elisa Domínguez-Hüttinger, Neville J Boon, Thomas B Clarke, Reiko J Tanaka
Streptococcus pneumoniae (Sp) is a commensal bacterium that normally resides on the upper airway epithelium without causing infection. However, factors such as co-infection with influenza virus can impair the complex Sp-host interactions and the subsequent development of many life-threatening infectious and inflammatory diseases, including pneumonia, meningitis or even sepsis. With the increased threat of Sp infection due to the emergence of new antibiotic resistant Sp strains, there is an urgent need for better treatment strategies that effectively prevent progression of disease triggered by Sp infection, minimizing the use of antibiotics...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28298146/companion-and-point-of-care-sensor-system-for-rapid-multiplexed-detection-of-a-panel-of-infectious-disease-markers
#6
Anjan Panneer Selvam, Shalini Prasad
A nanochannel-based electrochemical biosensor has been demonstrated for rapid and multiplexed detection of a panel of three biomarkers associated with rapid detection of sepsis. The label-free biosensor detected procalcitonin (PCT), lipoteichoic acid (LTA), and lipopolysaccharide (LPS) from human whole blood. The biosensor comprises a nanoporous nylon membrane integrated onto a microelectrode sensor platform for nanoconfinement effects. Charge perturbations due to biomarker binding are recorded as impedance changes using electrochemical impedance spectroscopy...
March 1, 2017: SLAS Technol
https://www.readbyqxmd.com/read/28290504/disease-dynamics-in-a-stochastic-network-game-a-little-empathy-goes-a-long-way-in-averting-outbreaks
#7
Ceyhun Eksin, Jeff S Shamma, Joshua S Weitz
Individuals change their behavior during an epidemic in response to whether they and/or those they interact with are healthy or sick. Healthy individuals may utilize protective measures to avoid contracting a disease. Sick individuals may utilize preemptive measures to avoid spreading a disease. Yet, in practice both protective and preemptive changes in behavior come with costs. This paper proposes a stochastic network disease game model that captures the self-interests of individuals during the spread of a susceptible-infected-susceptible disease...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28289265/contact-structure-mobility-environmental-impact-and-behaviour-the-importance-of-social-forces-to-infectious-disease-dynamics-and-disease-ecology
#8
REVIEW
Ronan F Arthur, Emily S Gurley, Henrik Salje, Laura S P Bloomfield, James H Jones
Human factors, including contact structure, movement, impact on the environment and patterns of behaviour, can have significant influence on the emergence of novel infectious diseases and the transmission and amplification of established ones. As anthropogenic climate change alters natural systems and global economic forces drive land-use and land-cover change, it becomes increasingly important to understand both the ecological and social factors that impact infectious disease outcomes for human populations...
May 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28289264/parasite-transmission-in-a-natural-multihost-multiparasite-community
#9
Stuart K J R Auld, Catherine L Searle, Meghan A Duffy
Understanding the transmission and dynamics of infectious diseases in natural communities requires understanding the extent to which the ecology, evolution and epidemiology of those diseases are shaped by alternative hosts. We performed laboratory experiments to test how parasite spillover affected traits associated with transmission in two co-occurring parasites: the bacterium Pasteuria ramosa and the fungus Metschnikowia bicuspidata Both parasites were capable of transmission from the reservoir host (Daphnia dentifera) to the spillover host (Ceriodaphnia dubia), but this occurred at a much higher rate for the fungus than the bacterium...
May 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28289260/host-heterogeneity-affects-both-parasite-transmission-to-and-fitness-on-subsequent-hosts
#10
Jessica F Stephenson, Kyle A Young, Jordan Fox, Jukka Jokela, Joanne Cable, Sarah E Perkins
Infectious disease dynamics depend on the speed, number and fitness of parasites transmitting from infected hosts ('donors') to parasite-naive 'recipients'. Donor heterogeneity likely affects these three parameters, and may arise from variation between donors in traits including: (i) infection load, (ii) resistance, (iii) stage of infection, and (iv) previous experience of transmission. We used the Trinidadian guppy, Poecilia reticulata, and a directly transmitted monogenean ectoparasite, Gyrodactylus turnbulli, to experimentally explore how these sources of donor heterogeneity affect the three transmission parameters...
May 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28289259/who-acquires-infection-from-whom-and-how-disentangling-multi-host-and-multi-mode-transmission-dynamics-in-the-elimination-era
#11
REVIEW
Joanne P Webster, Anna Borlase, James W Rudge
Multi-host infectious agents challenge our abilities to understand, predict and manage disease dynamics. Within this, many infectious agents are also able to use, simultaneously or sequentially, multiple modes of transmission. Furthermore, the relative importance of different host species and modes can itself be dynamic, with potential for switches and shifts in host range and/or transmission mode in response to changing selective pressures, such as those imposed by disease control interventions. The epidemiology of such multi-host, multi-mode infectious agents thereby can involve a multi-faceted community of definitive and intermediate/secondary hosts or vectors, often together with infectious stages in the environment, all of which may represent potential targets, as well as specific challenges, particularly where disease elimination is proposed...
May 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28289252/breaking-beta-deconstructing-the-parasite-transmission-function
#12
Hamish McCallum, Andy Fenton, Peter J Hudson, Brian Lee, Beth Levick, Rachel Norman, Sarah E Perkins, Mark Viney, Anthony J Wilson, Joanne Lello
Transmission is a fundamental step in the life cycle of every parasite but it is also one of the most challenging processes to model and quantify. In most host-parasite models, the transmission process is encapsulated by a single parameter β Many different biological processes and interactions, acting on both hosts and infectious organisms, are subsumed in this single term. There are, however, at least two undesirable consequences of this high level of abstraction. First, nonlinearities and heterogeneities that can be critical to the dynamic behaviour of infections are poorly represented; second, estimating the transmission coefficient β from field data is often very difficult...
May 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28286767/emerging-and-neglected-infectious-diseases-insights-advances-and-challenges
#13
REVIEW
Nicholas Israel Nii-Trebi
Infectious diseases are a significant burden on public health and economic stability of societies all over the world. They have for centuries been among the leading causes of death and disability and presented growing challenges to health security and human progress. The threat posed by infectious diseases is further deepened by the continued emergence of new, unrecognized, and old infectious disease epidemics of global impact. Over the past three and half decades at least 30 new infectious agents affecting humans have emerged, most of which are zoonotic and their origins have been shown to correlate significantly with socioeconomic, environmental, and ecological factors...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28284964/optimal-control-of-a-malaria-model-with-asymptomatic-class-and-superinfection
#14
Liming Cai, Xuezhi Li, Necibe Tuncer, Maia Martcheva, Abid Ali Lashari
In this paper, we introduce a malaria model with an asymptomatic class in human population and exposed classes in both human and vector populations. The model assumes that asymptomatic individuals can get re-infected and move to the symptomatic class. In the case of an incomplete treatment, symptomatic individuals move to the asymptomatic class. If successfully treated, the symptomatic individuals recover and move to the susceptible class. The basic reproduction number, R0, is computed using the next generation approach...
March 9, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28284250/estimating-tuberculosis-incidence-from-primary-survey-data-a-mathematical-modeling-approach
#15
S Pandey, V K Chadha, R Laxminarayan, N Arinaminpathy
BACKGROUND: There is an urgent need for improved estimations of the burden of tuberculosis (TB). OBJECTIVE: To develop a new quantitative method based on mathematical modelling, and to demonstrate its application to TB in India. DESIGN: We developed a simple model of TB transmission dynamics to estimate the annual incidence of TB disease from the annual risk of tuberculous infection and prevalence of smear-positive TB. We first compared model estimates for annual infections per smear-positive TB case using previous empirical estimates from China, Korea and the Philippines...
April 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28282928/oxidative-stress-a-new-target-for-pancreatic-cancer-prognosis-and-treatment
#16
REVIEW
Javier Martinez-Useros, Weiyao Li, Marticela Cabeza-Morales, Jesus Garcia-Foncillas
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of tumors, and its incidence is rising worldwide. Survival can be improved when tumors are detected at an early stage; however, this cancer is usually asymptomatic, and the disease only becomes apparent after metastasis. Several risk factors are associated to this disease. Chronic pancreatitis, diabetes, and some infectious disease are the most relevant risk factors. Incidence of PDAC has increased in the last decades. It is hypothesized it could be due to other acquired risk habits, like smoking, high alcohol intake, and obesity...
March 9, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28279627/making-new-connections-insights-from-primate-parasite-networks
#17
REVIEW
Julie Rushmore, Donal Bisanzio, Thomas R Gillespie
Social interactions are important in everyday life for primates and many other group-living animals; however, these essential exchanges also provide opportunities for parasites to spread through social groups. Network analysis is a unique toolkit for studying pathogen transmission in a social context, and recent primate-parasite network studies shed light on linkages between behavior and infectious disease dynamics, providing insights for conservation and public health. We review existing literature on primate-parasite networks, examining determinants of infection risk, issues of network scale and temporal dynamics, and applications for disease control...
March 6, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28275681/gastrointestinal-organoids-understanding-the-molecular-basis-of-the-host-microbe-interface
#18
REVIEW
David R Hill, Jason R Spence
In recent years, increasing attention has been devoted to the concept that microorganisms play an integral role in human physiology and pathophysiology. Despite this, the molecular basis of host-pathogen and host-symbiont interactions in the human intestine remains poorly understood owing to the limited availability of human tissue, and the biological complexity of host-microbe interactions. Over the past decade, technological advances have enabled long-term culture of organotypic intestinal tissue derived from human subjects and from human pluripotent stem cells, and these in vitro culture systems already have shown the potential to inform our understanding significantly of host-microbe interactions...
March 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28270509/in-situ-and-in-silico-kinetic-analyses-of-the-programmed-cell-death-1-programmed-cell-death-ligands-and-b7-1-interaction-network
#19
Kaitao Li, Xiaoxiao Cheng, Andreas Tilevik, Simon J Davis, Cheng Zhu
Programmed cell death-1 (PD-1) is an inhibitory receptor with an essential role in maintaining peripheral tolerance, and among the most promising immunotherapeutic targets for treating cancer, autoimmunity, and infectious diseases. A complete understanding of the consequences of PD-1 engagement by its ligands, PD-L1 and PD-L2, and of PD-L1 binding to B7-1, requires quantitative analysis of their interactions at the cell surface. We present here the first complete in situ kinetic analysis of the PD-1/PD-1 ligands/B7-1 system...
March 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28265742/connecting-virulence-pathways-to-cell-cycle-progression-in-the-fungal-pathogen-cryptococcus-neoformans
#20
REVIEW
Christina M Kelliher, Steven B Haase
Proliferation and host evasion are critical processes to understand at a basic biological level for improving infectious disease treatment options. The human fungal pathogen Cryptococcus neoformans causes fungal meningitis in immunocompromised individuals by proliferating in cerebrospinal fluid. Current antifungal drugs target "virulence factors" for disease, such as components of the cell wall and polysaccharide capsule in C. neoformans. However, mechanistic links between virulence pathways and the cell cycle are not as well studied...
March 6, 2017: Current Genetics
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