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Iron homeostasis

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https://www.readbyqxmd.com/read/28730560/impairment-of-ntca-gene-revealed-its-role-in-regulating-iron-homeostasis-ros-production-and-cellular-phenotype-under-iron-deficiency-in-cyanobacterium-anabaena-sp-pcc-7120
#1
Manish Singh Kaushik, Meenakshi Srivastava, Anumeha Singh, Arun Kumar Mishra
Iron deficiency ends up into several unavoidable consequences including damaging oxidative stress in cyanobacteria. NtcA is a global nitrogen regulator controls wide range of metabolisms in addition to regulation of nitrogen metabolism. In present communication, NtcA based regulation of iron homeostasis, ROS production and cellular phenotype under iron deficiency in Anabaena 7120 has been investigated. NtcA regulates the concentration dependent iron uptake by controlling the expression of furA gene. NtcA also regulated pigment synthesis and phenotypic alterations in Anabaena 7120...
August 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28724916/involvement-of-the-p62-nrf2-signal-transduction-pathway-on-erythrophagocytosis
#2
Inês B Santarino, Michelle S Viegas, Neuza S Domingues, Ana M Ribeiro, Miguel P Soares, Otília V Vieira
Erythrophagocytosis, the phagocytic removal of damaged red blood cells (RBC), and subsequent phagolysosome biogenesis are important processes in iron/heme metabolism and homeostasis. Phagolysosome biogenesis implies the interaction of nascent phagosomes with endocytic compartments and also autophagy effectors. Here, we report that besides recruitment of microtubule-associated protein-1-light chain 3 (LC3), additional autophagy machinery such as sequestosome 1 (p62) is also acquired by single-membrane phagosomes at very early stages of the phagocytic process and that its acquisition is very important to the outcome of the process...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717590/construction-of-a-fur-null-mutant-and-rna-sequencing-provide-deeper-global-understanding-of-the-aliivibrio-salmonicida-fur-regulon
#3
Sunniva Katharina Thode, Cecilie Bækkedal, Jenny Johansson Söderberg, Erik Hjerde, Hilde Hansen, Peik Haugen
BACKGROUND: The ferric uptake regulator (Fur) is a transcription factor and the main regulator of iron acquisition in prokaryotes. When bound to ferric iron, Fur recognizes its DNA binding site and generally executes its function by repressing transcription of its target genes. Due to its importance in virulence, the Fur regulon is well studied for several model bacteria. In our previous work, we used computational predictions and microarray to gain insights into Fur-regulation in Aliivibrio salmonicida, and have identified a number of genes and operons that appear to be under direct control of Fur...
2017: PeerJ
https://www.readbyqxmd.com/read/28715425/elimination-of-huntingtin-in-the-adult-mouse-leads-to-progressive-behavioral-deficits-bilateral-thalamic-calcification-and-altered-brain-iron-homeostasis
#4
Paula Dietrich, Irudayam Maria Johnson, Shanta Alli, Ioannis Dragatsis
Huntington's Disease (HD) is an autosomal dominant progressive neurodegenerative disorder characterized by cognitive, behavioral and motor dysfunctions. HD is caused by a CAG repeat expansion in exon 1 of the HD gene that is translated into an expanded polyglutamine tract in the encoded protein, huntingtin (HTT). While the most significant neuropathology of HD occurs in the striatum, other brain regions are also affected and play an important role in HD pathology. To date there is no cure for HD, and recently strategies aiming at silencing HTT expression have been initiated as possible therapeutics for HD...
July 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28714470/essential-role-of-fbxl5-mediated-cellular-iron-homeostasis-in-maintenance-of-hematopoietic-stem-cells
#5
Yoshiharu Muto, Masaaki Nishiyama, Akihiro Nita, Toshiro Moroishi, Keiichi I Nakayama
Hematopoietic stem cells (HSCs) are maintained in a hypoxic niche to limit oxidative stress. Although iron elicits oxidative stress, the importance of iron homeostasis in HSCs has been unknown. Here we show that iron regulation by the F-box protein FBXL5 is required for HSC self-renewal. Conditional deletion of Fbxl5 in mouse HSCs results in cellular iron overload and a reduced cell number. Bone marrow transplantation reveals that FBXL5-deficient HSCs are unable to reconstitute the hematopoietic system of irradiated recipients as a result of stem cell exhaustion...
July 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28713354/microbial-populations-of-stony-meteorites-substrate-controls-on-first-colonizers
#6
Alastair W Tait, Emma J Gagen, Siobhan A Wilson, Andrew G Tomkins, Gordon Southam
Finding fresh, sterilized rocks provides ecologists with a clean slate to test ideas about first colonization and the evolution of soils de novo. Lava has been used previously in first colonizer studies due to the sterilizing heat required for its formation. However, fresh lava typically falls upon older volcanic successions of similar chemistry and modal mineral abundance. Given enough time, this results in the development of similar microbial communities in the newly erupted lava due to a lack of contrast between the new and old substrates...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28712131/a-novel-antibacterial-peptide-derived-from-crocodylus-siamensis-hemoglobin-hydrolysate-induces-membrane-permeabilisation-causing-iron-dysregulation-oxidative-stress-and-bacterial-death
#7
J Lueangsakulthai, N Jangpromma, T Temsiripong, J E McKendrick, W Khunkitti, S E Maddocks, S Klaynongsruang
AIMS: A novel antibacterial peptide from Crocodylus siamensis hemoglobin hydrolysate (CHHs) was characterised for antimicrobial activity. METHODS AND RESULTS: CHHs was hydrolysed for 2 h (2h-CHH), 4 h (4h-CHH), 6 h (6h-CHH) and 8 h (8h-CHH). 8h-CHH showed antibacterial activity against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa at concentrations of 20, 20, 20 and 10 mg ml(-1) (w/v), respectively. Fluorescent microscopy revealed that 8h-CHH had bactericidal activity against E...
July 16, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28710073/zinc-mediates-the-srebp-scd-axis-to-regulate-lipid-metabolism-in-caenorhabditis-elegans
#8
Jing-Jing Zhang, Jun-Jun Hao, Yu-Ru Zhang, Yan-Li Wang, Ming-Yi Li, Hui-Lai Miao, Xiao-Ju Zou, Bin Liang
Maintenance of lipid homeostasis is crucial for cells in response to lipid requirements or surplus. The SREBPs transcription factors play essential roles in regulating lipid metabolism and are associated with many metabolic diseases. However, SREBP regulation of lipid metabolism is still less understood. Here, we show that reduction of SBP-1, the only homologue of SREBPs in C. elegans, surprisingly leads to high level of zinc. On the contrary, zinc reduction by mutation of sur-7, encoding a member of the cation diffusion facilitator (CDF) family, restores the fat accumulation and fatty acid profile of sbp-1(ep79) mutant...
July 14, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28707736/genetically-encoded-iron-associated-proteins-as-mri-reporters-for-molecular-and-cellular-imaging
#9
REVIEW
Anna V Naumova, Greetje Vande Velde
All cell imaging applications rely on some form of specific cell labeling to achieve visualization of cells contributing to disease or cell therapy. The purpose of this review article is to summarize the published data on genetically encoded iron-based imaging reporters. The article overviews regulation of iron homeostasis as well as genetically encoded iron-associated molecular probes and their applications for noninvasive magnetic resonance imaging (MRI) of transplanted cells. Longitudinal repetitive MRI of therapeutic cells is extremely important for providing key functional endpoints and insight into mechanisms of action...
July 14, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28705658/disturbance-of-redox-homeostasis-in-down-syndrome-role-of-iron-dysmetabolism
#10
REVIEW
Eugenio Barone, Andrea Arena, Elizabeth Head, D Allan Butterfield, Marzia Perluigi
Down syndrome (DS) is the most common genetic form of intellectual disability that leads in the majority of cases to development of early-onset Alzheimer-like dementia (AD). The neuropathology of DS has several common features with AD including alteration of redox homeostasis, mitochondrial deficits, and inflammation among others. Interestingly, some of the genes encoded by chromosome 21 are responsible of increased oxidative stress (OS) conditions that are further exacerbated by decreased antioxidant defense...
July 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28705644/discovery-of-ds79182026-a-potent-orally-active-hepcidin-production-inhibitor
#11
Takeshi Fukuda, Riki Goto, Toshihiro Kiho, Kenjiro Ueda, Sumie Muramatsu, Masami Hashimoto, Anri Aki, Kengo Watanabe, Naoki Tanaka
Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis. Inhibition of hepcidin could be a strategy favorable to treating anemia of chronic disease (ACD). We report herein the synthesis and structure-activity relationships (SARs) of a series of benzisoxazole compounds as orally active hepcidin production inhibitors. The optimization study of multi kinase inhibitor 1 led to a potent and bioavailable hepcidin production inhibitor 38 (DS79182026), which showed serum hepcidin lowering effects in a mouse IL-6 induced acute inflammatory model...
July 3, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28702035/the-soybean-basic-helix-loop-helix-transcription-factor-org3-like-enhances-cadmium-tolerance-via-increased-iron-and-reduced-cadmium-uptake-and-transport-from-roots-to-shoots
#12
Zhaolong Xu, Xiaoqing Liu, Xiaolan He, Ling Xu, Yihong Huang, Hongbo Shao, Dayong Zhang, Boping Tang, Hongxiang Ma
Cadmium (Cd) is one of the most dangerous heavy metal pollutants in the environment and is toxic to animal and plant cells. On the other hand, iron (Fe) is an essential element for plant growth and development. The chlorosis of plant leaves under cadmium stress is similar to the typical symptom of iron deficiency. Recently, several Arabidopsis basic/helix-loop-helix (bHLH) transcription factors have been identified that are involved in the interactions between Cd and Fe. In the present study, over-expression the ORG3-like gene GmORG3, a bHLH transcription factor OBP3-responsive gene (ORG), enhanced Cd tolerance and stabilized Fe homeostasis...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28702011/bridging-the-gap-to-non-toxic-fungal-control-lupinus-derived-blad-containing-oligomer-as-a-novel-candidate-to-combat-human-pathogenic-fungi
#13
Ana M Pinheiro, Alexandra Carreira, Thomas A K Prescott, Ricardo B Ferreira, Sara A Monteiro
The lack of antifungal drugs with novel modes of action reaching the clinic is a serious concern. Recently a novel antifungal protein referred to as Blad-containing oligomer (BCO) has received regulatory approval as an agricultural antifungal agent. Interestingly its spectrum of antifungal activity includes human pathogens such as Candida albicans, however, its mode of action has yet to be elucidated. Here we demonstrate that BCO exerts its antifungal activity through inhibition of metal ion homeostasis which results in apoptotic cell death in C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28698354/enhanced-secondary-and-hormone-metabolism-in-leaves-of-arbuscular-mycorrhizal-medicago-truncatula
#14
Lisa Adolfsson, Hugues Nziengui, Ilka N Abreu, Jan Šimura, Azeez Beebo, Andrei Herdean, Jila Aboalizadeh, Jitka Široká, Thomas Moritz, Ondřej Novák, Karin Ljung, Benoît Schoefs, Cornelia Spetea
Arbuscular mycorrhizas (AM) are the most common symbiotic associations between plant's root compartment and fungi. They provide nutritional benefit (mostly inorganic phosphate, Pi) leading to improved growth, and non-nutritional benefits including defense responses to environmental cues throughout the host plant, which in return delivers carbohydrates to the symbiont. However, how transcriptional and metabolic changes occurring in leaves of AM plants differ from those induced by Pi fertilization is poorly understood...
July 11, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28697999/the-protective-role-of-tet2-in-erythroid-iron-homeostasis-against-oxidative-stress-and-erythropoiesis
#15
Shanqi Guo, Xingkang Jiang, Yuanyuan Wang, Liwei Chen, Huzi Li, Xiaojiang Li, Yingjie Jia
Although previous studies suggested that stress erythropoiesis and iron metabolism regulate each other to increase iron availability for hemoglobin synthesis, the molecular bases determining its different traits remain elusive. In addition, global DNA demethylation has been reported during mouse erythropoiesis in vivo. However, the understanding of iron-related genes through DNA demethylation under stress erythropoiesis is largely unknown. In the current study, we found disordered iron homeostasis and misregulated hepcidin-ferroportin axis under stress erythropoiesis...
July 8, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28694024/iron-metabolism-state-of-the-art
#16
R Daher, Z Karim
Iron homeostasis relies on the amount of its absorption by the intestine and its release from storage sites, the macrophages. Iron homeostasis is also dependent on the amount of iron used for the erythropoiesis. Hepcidin, which is synthesized predominantly by the liver, is the main regulator of iron metabolism. Hepcidin reduces serum iron by inhibiting the iron exporter, ferroportin expressed both tissues, the intestine and the macrophages. In addition, in the enterocytes, hepcidin inhibits the iron influx by acting on the apical transporter, DMT1...
July 7, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28692912/effects-of-molybdenum-and-cadmium-on-the-oxidative-damage-and-kidney-apoptosis-in-duck
#17
Lele Shi, Huabin Cao, Junrong Luo, Ping Liu, Tiancheng Wang, Guoliang Hu, Caiying Zhang
Molybdenum (Mo) is an essential element for human beings and animals; however, high dietary intake of Mo can lead to adverse reactions. Cadmium (Cd) is one of the major transitional metals which has toxic effects in animals. To investigate the co-induced toxic effects of Mo and Cd on oxidative damage and kidney apoptosis in duck, 120 ducks were randomly divided into control group and 5 treatment groups which were treated with a commercial diet containing different dosages of Mo and Cd. Kidney samples were collected on the 60th and 120th days to determine the mRNA expression levels of ceruloplasmin (CP), metallothionein (MT), Bak-1, and Caspase-3 by quantitative RT-PCR...
July 7, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28692648/zebrafish-slc30a10-deficiency-revealed-a-novel-compensatory-mechanism-of-atp2c1-in-maintaining-manganese-homeostasis
#18
Zhidan Xia, Jiayu Wei, Yingniang Li, Jia Wang, Wenwen Li, Kai Wang, Xiaoli Hong, Lu Zhao, Caiyong Chen, Junxia Min, Fudi Wang
Recent studies found that mutations in the human SLC30A10 gene, which encodes a manganese (Mn) efflux transporter, are associated with hypermanganesemia with dystonia, polycythemia, and cirrhosis (HMDPC). However, the relationship between Mn metabolism and HMDPC is poorly understood, and no specific treatments are available for this disorder. Here, we generated two zebrafish slc30a10 mutant lines using the CRISPR/Cas9 system. Compared to wild-type animals, mutant adult animals developed significantly higher systemic Mn levels, and Mn accumulated in the brain and liver of mutant embryos in response to exogenous Mn...
July 10, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28691023/iron-homeostasis-in-tissues-is-affected-during-persistent-chlamydia-pneumoniae-infection-in-mice
#19
Marie Edvinsson, Jonas Tallkvist, Christina Nyström-Rosander, Nils-Gunnar Ilbäck
Chlamydia pneumoniae (C. pneumoniae) may be a mediator in the pathogenesis of atherosclerosis. For its growth C. pneumoniae depends on iron (Fe), but how Fe changes in tissues during persistent infection or affects bacterial replication in tissues is unknown. C. pneumoniae-infected C57BL/6J mice were sacrificed on days 4, 8, 20, and 40. Mice had bacteria in the lungs and liver on all days. Inflammatory markers, chemokine Cxcl2 and interferon-gamma, were not affected in the liver on day 40. The copper (Cu)/zinc (Zn) ratio in serum, another marker of infection/inflammation, increased on day 4 and tended to increase again on day 40...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28686269/iron-homeostasis-in-plants-a-brief-overview
#20
James M Connorton, Janneke Balk, Jorge Rodríguez-Celma
Iron plays a crucial role in biochemistry and is an essential micronutrient for plants and humans alike. Although plentiful in the Earth's crust it is not usually found in a form readily accessible for plants to use. They must therefore sense and interact with their environment, and have evolved two different molecular strategies to take up iron in the root. Once inside, iron is complexed with chelators and distributed to sink tissues where it is used predominantly in the production of enzyme cofactors or components of electron transport chains...
July 19, 2017: Metallomics: Integrated Biometal Science
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