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Iron homeostasis

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https://www.readbyqxmd.com/read/28521769/modeling-the-dynamics-of-mouse-iron-body-distribution-hepcidin-is-necessary-but-not-sufficient
#1
Jignesh H Parmar, Grey Davis, Hope Shevchuk, Pedro Mendes
BACKGROUND: Iron is an essential element of most living organisms but is a dangerous substance when poorly liganded in solution. The hormone hepcidin regulates the export of iron from tissues to the plasma contributing to iron homeostasis and also restricting its availability to infectious agents. Disruption of iron regulation in mammals leads to disorders such as anemia and hemochromatosis, and contributes to the etiology of several other diseases such as cancer and neurodegenerative diseases...
May 18, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28521682/repurposing-of-copper-ii-chelating-drugs-for-the-treatment-of-neurodegenerative-diseases
#2
Valeria Lanza, Danilo Milardi, Giuseppe Di Natale, Giuseppe Pappalardo
BACKGROUND: There is mounting urgency to find new drugs for the treatment of neurodegenerative disorders. A large number of reviews has exhaustively described either the molecular or clinical aspects of neurodegenerative diseases as Alzheimer's (AD) and Parkinson's (PD). Conversely, reports outlining how known drugs in use for other diseases can be also effective as therapeutic agents in neurodegenerative diseases are less reported. This review focuses on the current uses of some copper(II) interacting molecules as potential drug candidates in neurodegeneration...
May 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28516990/cross-talk-between-neurometals-and-amyloidogenic-proteins-at-the-synapse-and-the-pathogenesis-of-neurodegenerative-diseases
#3
REVIEW
M Kawahara, M Kato-Negishi, K Tanaka
Increasing evidence suggests that disruption of metal homeostasis contributes to the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease, prion diseases, Lewy body diseases, and vascular dementia. Conformational changes of disease-related proteins (amyloidogenic proteins), such as β-amyloid protein, prion proteins, and α-synuclein, are well-established contributors to neurotoxicity and to the pathogenesis of these diseases. Recent studies have demonstrated that these amyloidogenic proteins are metalloproteins that bind trace elements, including zinc, iron, copper, and manganese, and play significant roles in the maintenance of metal homeostasis...
May 18, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28514781/hepcidin-homeostasis-and-diseases-related-to-iron-metabolism
#4
Cadiele Oliana Reichert, Joel da Cunha, Débora Levy, Luciana Morganti Ferreira Maselli, Sérgio Paulo Bydlowski, Celso Spada
Iron is an essential metal for cell survival that is regulated by the peptide hormone hepcidin. However, its influence on certain diseases is directly related to iron metabolism or secondary to underlying diseases. Genetic alterations influence the serum hepcidin concentration, which can lead to an iron overload in tissues, as observed in haemochromatosis, in which serum hepcidin or defective hepcidin synthesis is observed. Another genetic imbalance of iron is iron-refractory anaemia, in which serum concentrations of hepcidin are increased, precluding the flow and efflux of extra- and intracellular iron...
May 18, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28512090/the-vibrio-cholerae-vexgh-rnd-efflux-system-maintains-cellular-homeostasis-by-effluxing-vibriobactin
#5
Dillon E Kunkle, X Renee Bina, James E Bina
Resistance-nodulation-division (RND) superfamily efflux systems have been widely studied for their role in antibiotic resistance, but their native biological functions remain poorly understood. We previously showed that loss of RND-mediated efflux in Vibrio cholerae resulted in activation of the Cpx two-component regulatory system, which mediates adaptation to stress resulting from misfolded membrane proteins. Here, we investigated the mechanism linking RND-mediated efflux to the Cpx response. We performed transposon mutagenesis screening of RND-deficient V...
May 16, 2017: MBio
https://www.readbyqxmd.com/read/28511798/induction-of-copper-and-iron-in-acute-cold-stimulated-brown-adipose-tissues
#6
Chao Wang, Xiaojuan Liang, Cong Tao, Xiaolei Yao, Yajun Wang, Yanfang Wang, Kui Li
Copper (Cu) and iron (Fe), the enzymatic cofactors required for various biochemical processes, have been recently linked to lipid metabolism. Adipose tissues play central roles in energy balance and whether copper and iron homeostasis is involved in cold-stimulated energy metabolism remain unknown. In this study, the Cu and Fe contents in interscapular brown adipose tissue (BAT) and subcutaneous white adipose tissue (WAT) from mice at different developmental stages were measured. Our results revealed the dynamic changes of Cu and Fe levels during development, suggesting their potential roles in energy homeostasis...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28507548/iron-and-hepcidin-independent-downregulation-of-the-iron-exporter-ferroportin-in-macrophages-during-salmonella-infection
#7
Alexandra Willemetz, Sean Beatty, Etienne Richer, Aude Rubio, Anne Auriac, Ruth J Milkereit, Olivier Thibaudeau, Sophie Vaulont, Danielle Malo, François Canonne-Hergaux
Retention of iron in tissue macrophages via upregulation of hepcidin (HAMP) and downregulation of the iron exporter ferroportin (FPN) is thought to participate in the establishment of anemia of inflammation after infection. However, an upregulation of FPN has been proposed to limit macrophages iron access to intracellular pathogens. Therefore, we studied the iron homeostasis and in particular the regulation of FPN after infection with Salmonella enterica serovar Typhimurium in mice presenting tissue macrophages with high iron (AcB61), basal iron (A/J and wild-type mice), or low iron (Hamp knock out, Hamp(-/-)) levels...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28501597/reciprocal-regulation-between-hepcidin-and-erythropoiesis-and-its-therapeutic-application-in-erythroid-disorders
#8
REVIEW
Caiyi Wang, Zheng Fang, Zesen Zhu, Jing Liu, Huiyong Chen
Iron is required for hemoglobin production, and it plays a key role during erythropoiesis. Systemic iron homeostasis is mainly negatively regulated by the peptide hormone hepcidin, coded by the gene HAMP. Hepcidin excess may cause iron deficiency, iron-restricted erythropoiesis and anemia. Conversely, hepcidin insufficiency leads to iron overload and oxidative damage in multiple tissues. During regulation of hepcidin synthesis, multiple promoter elements in the HAMP gene respond to variable signaling pathways corresponding to different extracellular situations...
May 10, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/28500270/heavy-metals-induce-iron-deficiency-responses-at-different-hierarchic-and-regulatory-levels
#9
Alexandra Leskova, Ricardo Fabiano Hettwer Giehl, Anja Hartmann, Agáta Fargasová, Nicolaus von Wirén
In plants, the excess of several heavy metals mimics Fe deficiency-induced chlorosis indicating a disturbance in Fe homeostasis. To examine at which level heavy metals interfere with Fe-deficiency responses, we carried out an in-depth characterization of Fe-related physiological, regulatory and morphological responses in Arabidopsis thaliana exposed to heavy metals. Enhanced Zn uptake closely mimicked Fe deficiency by leading to low chlorophyll but high ferric-chelate reductase activity and coumarin release...
May 12, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28499955/transcriptomic-analysis-of-saccharomyces-cerevisiae-upon-honokiol-treatment
#10
Xiaolong Zhu, Shenshen Zou, Youbin Li, Yongheng Liang
Honokiol (HNK), one of the main medicinal components in Magnolia officinalis, possesses antimicrobial activity against a variety of pathogenic bacteria and fungi. However, little is known of the molecular mechanisms underpinning the antimicrobial activity. To explore the molecular mechanism of its antifungal activity, we determined the effects of HNK on the mRNA expression profile of Saccharomyces cerevisiae using a DNA microarray approach. HNK markedly induced the expression of genes related to iron uptake and homeostasis...
May 10, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28495571/role-of-iron-in-the-pathogenesis-of-respiratory-disease
#11
REVIEW
Md Khadem Ali, Richard Y Kim, Rafia Karim, Jemma R Mayall, Kristy L Martin, Ali Shahandeh, Firouz Abbasian, Malcolm R Starkey, Veronique Loustaud-Ratti, Daniel Johnstone, Elizabeth A Milward, Philip M Hansbro, Jay C Horvat
Iron is essential for many biological processes, however, too much or too little iron can result in a wide variety of pathological consequences, depending on the organ system, tissue or cell type affected. In order to reduce pathogenesis, iron levels are tightly controlled in throughout the body by regulatory systems that control iron absorption, systemic transport and cellular uptake and storage. Altered iron levels and/or dysregulated homeostasis have been associated with several lung diseases, including chronic obstructive pulmonary disease, lung cancer, cystic fibrosis, idiopathic pulmonary fibrosis and asthma...
May 7, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28483855/the-association-of-metal-homeostasis-and-p-ppgpp-regulation-in-the-pathophysiology-of-enterococcus-faecalis
#12
C Colomer-Winter, A O Gaca, J A Lemos
In Enterococcus faecalis, the regulatory nucleotides pppGpp and ppGpp, collectively (p)ppGpp, are required for growth in blood, survival within macrophages and virulence. However, a clear understanding of how (p)ppGpp promotes virulence in E. faecalis and other bacterial pathogens is still lacking. In the host, the essential transition metals iron (Fe) and manganese (Mn) are not readily available to invading pathogens because of a host-driven process called nutritional immunity. Considering its central role in adaptation to nutritional stresses, we hypothesized that (p)ppGpp mediates E...
May 8, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28481273/agronomic-approach-of-zinc-biofortification-can-increase-zinc-bioavailability-in-wheat-flour-and-thereby-reduce-zinc-deficiency-in-humans
#13
Dunyi Liu, Yumin Liu, Wei Zhang, Xinping Chen, Chunqin Zou
Zinc (Zn) deficiency is a common disorder of humans in developing countries. The effect of Zn biofortification (via application of six rates of Zn fertilizer to soil) on Zn bioavailability in wheat grain and flour and its impacts on human health was evaluated. Zn bioavailability was estimated with a trivariate model that included Zn homeostasis in the human intestine. As the rate of Zn fertilization increased, the Zn concentration increased in all flour fractions, but the percentages of Zn in standard flour (25%) and bran (75%) relative to total grain Zn were constant...
May 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28480557/molecular-regulation-of-cellular-iron-balance
#14
REVIEW
Stefania Recalcati, Elena Gammella, Paolo Buratti, Gaetano Cairo
Handling a life-supporting yet redox-active metal like iron represents a significant challenge to cells and organisms that must not only tightly balance intra- and extracellular iron concentrations but also chaperone it during its journey from its point of entry to final destinations, to prevent inappropriate generation of damaging reactive oxygen species. Accordingly, regulatory mechanisms have been developed to maintain appropriate cellular and body iron levels. In intracellular compartments, about 95% of iron is protein-bound and the expression of the major proteins of iron metabolism is controlled by an integrated and dynamic system involving multilayered levels of regulation...
May 7, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28479323/acclimation-of-oxygenic-photosynthesis-to-iron-starvation-is-controlled-by-the-srna-isar1
#15
Jens Georg, Gergana Kostova, Linda Vuorijoki, Verena Schön, Taro Kadowaki, Tuomas Huokko, Desirée Baumgartner, Maximilian Müller, Stephan Klähn, Yagut Allahverdiyeva, Yukako Hihara, Matthias E Futschik, Eva-Mari Aro, Wolfgang R Hess
Oxygenic photosynthesis crucially depends on proteins that possess Fe(2+) or Fe/S complexes as co-factors or prosthetic groups. Here, we show that the small regulatory RNA (sRNA) IsaR1 (Iron-Stress-Activated RNA 1) plays a pivotal role in acclimation to low-iron conditions. The IsaR1 regulon consists of more than 15 direct targets, including Fe(2+)-containing proteins involved in photosynthetic electron transfer, detoxification of anion radicals, citrate cycle, and tetrapyrrole biogenesis. IsaR1 is essential for maintaining physiological levels of Fe/S cluster biogenesis proteins during iron deprivation...
May 2, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28474781/the-hemochromatosis-protein-hfe-20-years-later-an-emerging-role-in-antigen-presentation-and-in-the-immune-system
#16
REVIEW
Alexandre Reuben, Jacqueline W Chung, Réjean Lapointe, Manuela M Santos
INTRODUCTION: Since its discovery, the hemochromatosis protein HFE has been primarily defined by its role in iron metabolism and homeostasis, and its involvement in the genetic disease termed hereditary hemochromatosis (HH). While HH patients are typically afflicted by dysregulated iron levels, many are also affected by several immune defects and increased incidence of autoimmune diseases that have thereby implicated HFE in the immune response. Growing evidence has supported an immunological role for HFE with recent studies describing HFE specifically as it relates to MHC I antigen presentation...
April 19, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28474474/iron-metabolism-and-the-inflammatory-response
#17
Ana C Martins, Joana I Almeida, Illyane S Lima, Antonino S Kapitão, Raffaella Gozzelino
Iron (Fe) is essential to almost all organisms, as required by cells to satisfy metabolic needs and accomplish specialized functions. Its ability to exchange electrons between different substrates, however, renders it potentially toxic. Fine tune-mechanisms are necessary to maintain Fe homeostasis and, as such, to prevent its participation into the Fenton reaction and generation of oxidative stress. These are particularly important in the context of inflammation/infection, where restricting Fe availability to invading pathogens is one, if not, the main host defense strategy against microbial growth...
May 5, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28467453/functional-analysis-of-two-sterol-regulatory-element-binding-proteins-in-penicillium-digitatum
#18
Ruoxin Ruan, Mingshuang Wang, Xin Liu, Xuepeng Sun, Kuang-Ren Chung, Hongye Li
The sterol regulatory element binding proteins (SREBPs) are key regulators for sterol homeostasis in most fungi. In the citrus postharvest pathogen Penicillium digitatum, the SREBP homolog is required for fungicide resistance and regulation of CYP51 expression. In this study, we identified another SREBP transcription factor PdSreB in P. digitatum, and the biological functions of both SREBPs were characterized and compared. Inactivation of PdsreA, PdsreB or both genes in P. digitatum reduced ergosterol contents and increased sensitivities to sterol 14-α-demethylation inhibitors (DMIs) and cobalt chloride...
2017: PloS One
https://www.readbyqxmd.com/read/28467369/developmental-control-of-nramp1-slc11a1-expression-in-professional-phagocytes
#19
Mathieu F M Cellier
NRAMP1 (SLC11A1) is a professional phagocyte membrane importer of divalent metals that contributes to iron recycling at homeostasis and to nutritional immunity against infection. Analyses of data generated by several consortia and additional studies were integrated to hypothesize mechanisms restricting NRAMP1 expression to mature phagocytes. Results from various epigenetic and transcriptomic approaches were collected for mesodermal and hematopoietic cell types and compiled for combined analysis with results of genetic studies associating single nucleotide polymorphisms (SNPs) with variations in NRAMP1 expression (eQTLs)...
May 3, 2017: Biology
https://www.readbyqxmd.com/read/28467345/iron-deficiency-anemia-and-glucose-metabolism
#20
Ashraf T Soliman, Vincenzo De Sanctis, Mohamed Yassin, Nada Soliman
Iron deficiency anemia (IDA) is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic development. It occurs at all stages of the life cycle, but is more prevalent in pregnant women and young children. IDA appears to be more common in diabetic patients compared to non-diabetic population. Iron deficiency (ID) and IDA can impair glucose homeostasis in animals and human and may negatively affect glycemic control and predispose to more complications in diabetic patients...
April 28, 2017: Acta Bio-medica: Atenei Parmensis
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