keyword
https://read.qxmd.com/read/37310664/transposon-insertion-profiling-by-sequencing-tipseq-identifies-novel-line-1-insertions-in-human-sperm
#21
JOURNAL ARTICLE
Thalita S Berteli, Fang Wang, Wilson McKerrow, Paula A Navarro, David Fenyo, Jef D Boeke, Fabiana B Kohlrausch, David L Keefe
PURPOSE: Long interspersed nuclear element-1 (LINE-1 or L1) comprises 17% of the human genome. Retrotransposons may perturb gene integrity or alter gene expression by altering regulatory regions in the genome. The germline employs a number of mechanisms, including cytosine methylation, to repress retrotransposon transcription throughout most of life. Demethylation during germ cell and early embryo development de-represses retrotransposons. Intriguingly, de novo genetic variation appearing in sperm has been implicated in a number of disorders in offspring, including autism spectrum disorder, schizophrenia, and bipolar disorder...
June 13, 2023: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/37263043/a-maturational-shift-in-the-frontal-cortex-synaptic-transcriptional-landscape-underlies-schizophrenia-relevant-behavioural-traits-a-congenital-rat-model
#22
JOURNAL ARTICLE
Marie Sønderstrup, Mykhailo Y Batiuk, Panagiotis Mantas, Carles Tapias-Espinosa, Ignasi Oliveras, Toni Cañete, Daniel Sampedro-Viana, Tomasz Brudek, Rasmus Rydbirk, Konstantin Khodosevich, Alberto Fernandez-Teruel, Betina Elfving, Susana Aznar
Disruption of brain development early in life may underlie the neurobiology behind schizophrenia. We have reported more immature synaptic spines in the frontal cortex (FC) of adult Roman High-Avoidance (RHA-I) rats, a behavioural model displaying schizophrenia-like traits. Here, we performed a whole transcriptome analysis in the FC of 4 months old male RHA-I (n=8) and its counterpart, the Roman Low-Avoidance (RLA-I) (n=8). We identified 203 significant genes with overrepresentation of genes involved in synaptic function...
May 30, 2023: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/37252132/a-systems-biology-approach-for-discovering-the-cellular-and-molecular-aspects-of-psychogenic-non-epileptic-seizure
#23
JOURNAL ARTICLE
Mahdi Malekpour, Aida Jafari, Mohammad Kashkooli, Seyed Reza Salarikia, Manica Negahdaripour
OBJECTIVES: Psychogenic non-epileptic seizure (PNES) is the most common non-epileptic disorder in patients referring to epilepsy centers. Contrary to common beliefs about the disease's harmlessness, the death rate of PNES patients is similar to drug-resistant epilepsy. Meanwhile, the molecular pathomechanism of PNES is unknown with very limited related research. Thus, the aim of this in silico study was to find different proteins and hormones associated with PNES via a systems biology approach...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/37151698/disc1-as-a-prognostic-biomarker-correlated-with-immune-infiltrates-in-gastric-cancer
#24
JOURNAL ARTICLE
Shiyao Zheng, Yongyuan Chen, Shiya Yu, Caiming Weng, Nan Lin, Ziqiang Luo, Yuanzhao Wang, Ping Xiong, Zhun Teng, Yu Wang, Hu Zhao, Chunhong Xiao
Multiple mental diseases could arise in people who have the disrupted in schizophrenia 1 (DISC1) gene. However, it was unknown how DISC1 might contribute to the development of tumors and immune responses. We extracted data from the Cancer Genome Atlas (TCGA) and TISIDB databases from stomach adenocarcinoma (STAD) patients, which revealed that DISC1 overexpression was closely associated with tumor histological type (mucinous vs. tubular, OR = 2.860, CI = 1.423-5.872, p = 0.004), as well as tumor stage and grade...
April 2023: Heliyon
https://read.qxmd.com/read/37033658/analysis-of-networks-in-the-dorsolateral-prefrontal-cortex-in-chronic-schizophrenia-relevance-of-altered-immune-response
#25
JOURNAL ARTICLE
América Vera-Montecinos, Ricard Rodríguez-Mias, Èlia Vila, Judit Villén, Belén Ramos
The dorsolateral prefrontal cortex (DLPFC) has a crucial role in cognitive functioning and negative symptoms in schizophrenia. However, limited information of altered protein networks is available in this region in schizophrenia. We performed a proteomic analysis using single-shot liquid chromatography-tandem mass spectrometry of grey matter of postmortem DLPFC in chronic schizophrenia subjects (n = 20) and unaffected subjects (n = 20) followed by bioinformatic analysis to identify altered protein networks in schizophrenia (PXD024939 identifier in ProteomeXchange repository)...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37027465/widespread-rna-hypoediting-in-schizophrenia-and-its-relevance-to-mitochondrial-function
#26
JOURNAL ARTICLE
Mudra Choudhury, Ting Fu, Kofi Amoah, Hyun-Ik Jun, Tracey W Chan, Sungwoo Park, David W Walker, Jae Hoon Bahn, Xinshu Xiao
RNA editing, the endogenous modification of nucleic acids, is known to be altered in genes with important neurological function in schizophrenia (SCZ). However, the global profile and molecular functions of disease-associated RNA editing remain unclear. Here, we analyzed RNA editing in postmortem brains of four SCZ cohorts and uncovered a significant and reproducible trend of hypoediting in patients of European descent. We report a set of SCZ-associated editing sites via WGCNA analysis, shared across cohorts...
April 7, 2023: Science Advances
https://read.qxmd.com/read/36982982/co-expression-network-analysis-identifies-molecular-determinants-of-loneliness-associated-with-neuropsychiatric-and-neurodegenerative-diseases
#27
JOURNAL ARTICLE
Jose A Santiago, James P Quinn, Judith A Potashkin
Loneliness and social isolation are detrimental to mental health and may lead to cognitive impairment and neurodegeneration. Although several molecular signatures of loneliness have been identified, the molecular mechanisms by which loneliness impacts the brain remain elusive. Here, we performed a bioinformatics approach to untangle the molecular underpinnings associated with loneliness. Co-expression network analysis identified molecular 'switches' responsible for dramatic transcriptional changes in the nucleus accumbens of individuals with known loneliness...
March 21, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36924079/genome-wide-association-studies-reveal-shared-genetic-haplotypes-of-autoimmune-rheumatic-and-endocrine-diseases-with-psychiatric-disorders
#28
JOURNAL ARTICLE
Konstantinos Voskarides, Nefeli Giannopoulou, Rasha Eid, Konstantinos Parperis, Andreas Chatzittofis
BACKGROUND: Several studies have shown that autoimmune diseases are associated with psychiatric diseases like depression and psychosis. Genetic evidence supports this association. The aim of this study was to investigate if genetic variants predisposing to autoimmune diseases and psychiatric disorders are genetically linked, constructing the common haplotypes. METHODS: All registered single nucleotide polymorphisms (SNPs) in the Genome-wide association studies ("GWAS catalog") having been associated with autoimmune rheumatic and endocrine diseases were investigated for being in linkage disequilibrium with any psychiatric disorders' associated SNPs...
March 16, 2023: Brain and Behavior
https://read.qxmd.com/read/36902031/transcriptomic-analyses-of-brains-of-rbm8a-conditional-knockout-mice-at-different-developmental-stages-reveal-conserved-signaling-pathways-contributing-to-neurodevelopmental-diseases
#29
JOURNAL ARTICLE
Colleen McSweeney, Miranda Chen, Fengping Dong, Aswathy Sebastian, Derrick James Reynolds, Jennifer Mott, Zifei Pei, Jizhong Zou, Yongsheng Shi, Yingwei Mao
RNA-binding motif 8A (RBM8A) is a core component of the exon junction complex (EJC) that binds pre-mRNAs and regulates their splicing, transport, translation, and nonsense-mediated decay (NMD). Dysfunction in the core proteins has been linked to several detriments in brain development and neuropsychiatric diseases. To understand the functional role of Rbm8a in brain development, we have generated brain-specific Rbm8a knockout mice and used next-generation RNA-sequencing to identify differentially expressed genes (DEGs) in mice with heterozygous, conditional knockout (cKO) of Rbm8a in the brain at postnatal day 17 (P17) and at embryonic day 12...
February 27, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36738648/establishment-of-a-schizophrenia-classifier-based-on-peripheral-blood-signatures-and-investigation-of-pathogenic-mirna-mrna-regulation
#30
JOURNAL ARTICLE
Mengdi Jin, Yane Liu, Guoyan Hu, Xinwei Li, Ningning Jia, Xingyao Cui, Zhijun Li, Lizhe Ai, Mengtong Xie, Fengyu Xue, Yuqing Yang, Weizhen Li, Min Zhang, Qiong Yu
To date, the diagnosis of schizophrenia (SCZ) mainly relies on patients' or guardians' self-reports and clinical observation, and the pathogenesis of SCZ remains elusive. In this study, we sought to develop a reliable classifier for diagnosing SCZ patients and provide clues to the etiology and pathogenesis of SCZ. Based on the high throughput sequencing analysis of peripheral blood miRNA expression profile and weighted gene co-expression network analysis (WGCNA) in our previous study, we selected eleven hub miRNAs for validation by qRT-PCR in 51 SCZ patients and 51 controls...
January 29, 2023: Journal of Psychiatric Research
https://read.qxmd.com/read/36641432/disclosing-common-biological-signatures-and-predicting-new-therapeutic-targets-in-schizophrenia-and-obsessive-compulsive-disorder-by-integrated-bioinformatics-analysis
#31
JOURNAL ARTICLE
Abdolhakim Ghanbarzehi, Ali Sepehrinezhad, Nazanin Hashemi, Minoo Karimi, Ali Shahbazi
Schizophrenia (SCZ) is a severe mental illness mainly characterized by a number of psychiatric symptoms. Obsessive-compulsive disorder (OCD) is a long-lasting and devastating mental disorder. SCZ has high co-occurrence with OCD resulting in the emergence of a concept entitled "schizo-obsessive disorder" as a new specific clinical entity with more severe psychiatric symptoms. Many studies have been done on SCZ and OCD, but the common pathogenesis between them is not clear yet. Therefore, this study aimed to identify shared genetic basis, potential biomarkers and therapeutic targets between these two disorders...
January 14, 2023: BMC Psychiatry
https://read.qxmd.com/read/36613876/mapping-mirna-research-in-schizophrenia-a-scientometric-review
#32
REVIEW
Mengyu Lim, Alessandro Carollo, Michelle Jin Yee Neoh, Gianluca Esposito
Micro RNA (miRNA) research has great implications in uncovering the aetiology of neuropsychiatric conditions due to the role of miRNA in brain development and function. Schizophrenia, a complex yet devastating neuropsychiatric disorder, is one such condition that had been extensively studied in the realm of miRNA. Although a relatively new field of research, this area of study has progressed sufficiently to warrant dozens of reviews summarising findings from past to present. However, as a majority of reviews cannot encapsulate the full body of research, there is still a need to synthesise the diversity of publications made in this area in a systematic but easy-to-understand manner...
December 27, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36597047/a-gene-based-combination-test-using-gwas-summary-data
#33
JOURNAL ARTICLE
Jianjun Zhang, Xiaoyu Liang, Samantha Gonzales, Jianguo Liu, Xiaoyi Raymond Gao, Xuexia Wang
BACKGROUND: Gene-based association tests provide a useful alternative and complement to the usual single marker association tests, especially in genome-wide association studies (GWAS). The way of weighting for variants in a gene plays an important role in boosting the power of a gene-based association test. Appropriate weights can boost statistical power, especially when detecting genetic variants with weak effects on a trait. One major limitation of existing gene-based association tests lies in using weights that are predetermined biologically or empirically...
January 3, 2023: BMC Bioinformatics
https://read.qxmd.com/read/36561887/mir-146a-and-mir-200b-alter-cognition-by-targeting-nmda-receptor-subunits
#34
JOURNAL ARTICLE
Sowmya Gunasekaran, Ramakrishnapillai Vyomakesannair Omkumar
MicroRNAs fine-tune gene regulation and can be targeted for therapeutic purposes. We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms. Using bioinformatics tools and luciferase assay, we show interaction of these miRNAs with transcripts of N-methyl-D-aspartate receptor (NMDAR) subunits Grin2A and Grin2B . Overexpression of these miRNAs in primary hippocampal neurons caused downregulation of GluN2B and GluN2A proteins...
December 22, 2022: IScience
https://read.qxmd.com/read/36429060/intranasal-peptide-therapeutics-a-promising-avenue-for-overcoming-the-challenges-of-traditional-cns-drug-development
#35
REVIEW
Meenakshi Bose, Gabriela Farias Quipildor, Michelle E Ehrlich, Stephen R Salton
The central nervous system (CNS) has, among all organ systems in the human body, the highest failure rate of traditional small-molecule drug development, ranging from 80-100% depending on the area of disease research. This has led to widespread abandonment by the pharmaceutical industry of research and development for CNS disorders, despite increased diagnoses of neurodegenerative disorders and the continued lack of adequate treatment options for brain injuries, stroke, neurodevelopmental disorders, and neuropsychiatric illness...
November 16, 2022: Cells
https://read.qxmd.com/read/36421842/identification-of-ferroptosis-related-genes-in-schizophrenia-based-on-bioinformatic-analysis
#36
JOURNAL ARTICLE
Shunkang Feng, Jun Chen, Chunhui Qu, Lu Yang, Xiaohui Wu, Shuo Wang, Tao Yang, Hongmei Liu, Yiru Fang, Ping Sun
The purpose of this study is to explore the correlation between ferroptosis-related genes and schizophrenia in order to explore the new direction of diagnosis and treatment of schizophrenia. We screened the datasets related to schizophrenia from the Gene Expression Comprehensive Database (GEO) and obtained ferroptosis-related genes from the FerrDB database. Bioinformatics methods were used to analyze differentially expressed genes (DEGs) and genes associated with ferroptosis-related between schizophrenia patients and healthy controls...
November 20, 2022: Genes
https://read.qxmd.com/read/36410410/comprehensive-bioinformatics-analysis-and-molecular-validation-of-lncrnas-mediated-cernas-network-in-schizophrenia
#37
JOURNAL ARTICLE
Jiequan Wang, Yaru Liu, Yejun Gao, Jun Liang, Baoshi Wang, Quan Xia, Yawen Xie, Feng Shan, Qingrong Xia
AIMS: The present study aimed to investigate how Schizophrenia (SCZ)-specific long non-coding RNAs (lncRNAs) served as competing endogenous RNAs (ceRNAs) to modulate the biological functions and pathways involved in the pathogenesis of SCZ. MAIN METHODS: Microarray dataset (GSE54913) was obtained from Gene Expression Omnibus (GEO) database. Differently expressed (DE) lncRNAs and mRNAs were identified by "limma" package. The binding miRNAs of lncRNAs and target mRNAs of shared miRNAs were predicted by miRcode, miRDB, miRTarbase and targetscan databases...
November 18, 2022: Life Sciences
https://read.qxmd.com/read/36405929/identification-of-key-long-non-coding-rna-associated-competing-endogenous-rna-axes-in-brodmann-area-10-brain-region-of-schizophrenia-patients
#38
JOURNAL ARTICLE
Hani Sabaie, Mahdi Gholipour, Mohammad Reza Asadi, Samin Abed, Mirmohsen Sharifi-Bonab, Mohammad Taheri, Bashdar Mahmud Hussen, Serge Brand, Seyedeh Morvarid Neishabouri, Maryam Rezazadeh
Schizophrenia (SCZ) is a serious mental condition with an unknown cause. According to the reports, Brodmann Area 10 (BA10) is linked to the pathology and cortical dysfunction of SCZ, which demonstrates a number of replicated findings related to research on SCZ and the dysfunction in tasks requiring cognitive control in particular. Genetics' role in the pathophysiology of SCZ is still unclear. Therefore, it may be helpful to understand the effects of these changes on the onset and progression of SCZ to find novel mechanisms involved in the regulation of gene transcription...
2022: Frontiers in Psychiatry
https://read.qxmd.com/read/36335997/dysfunctional-microrna-144-3p-zbtb20-erk-creb1-signalling-pathway-is-associated-with-mk-801-induced-schizophrenia-like-abnormalities
#39
JOURNAL ARTICLE
Bo Pan, Bing Han, Xiaoli Zhu, Yuting Wang, Hongyan Ji, Jianjun Weng, Yanqing Liu
Schizophrenia is a group of severe mental disorders. ZBTB20 is critical in brain development and corticogenesis and its dysfunction induces various neural disorders. ERK/CREB signalling is a potential downstream pathway of ZBTB20. Up-regulated microRNA-144-3p (miR-144-3p) were found in schizophrenic model rats in our previous study. This study investigated whether suppressed ZBTB20/ERK/CREB1 signalling caused by up-regulated miR-144-3p is associated with schizophrenia-like abnormalities in animals. A MK-801 rat model was established by 2-week MK-801 administration...
November 3, 2022: Brain Research
https://read.qxmd.com/read/36334618/a-de-novo-mutation-p-s1419f-of-retinoic-acid-induced-1-is-responsible-for-a-patient-with-smith-magenis-syndrome-exhibiting-schizophrenia
#40
JOURNAL ARTICLE
Rong Yu, Lv Liu, Chan Chen, Zhao-Jing Lin, Jun-Mei Xu, Liang-Liang Fan
Smith-Magenis syndrome (SMS, OMIM# 182290) is a rare congenital disorder which characterized by multiple abnormalities involving in craniofacial, skeletal, otorhinolaryngolocial, neurological, behavioral and others. 17p11.2 microdeletion and RAI1 mutations have been proven to be genetic lesions of this disease. However, the relationship between RAI1 variants and different phenotypes is still unclear. The discoveries of more RAI1 mutations in patients with different phenotypes will help to elucidate the pathogenesis of the RAI1 gene...
November 2, 2022: Gene
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