Mengdi Jin, Yane Liu, Guoyan Hu, Xinwei Li, Ningning Jia, Xingyao Cui, Zhijun Li, Lizhe Ai, Mengtong Xie, Fengyu Xue, Yuqing Yang, Weizhen Li, Min Zhang, Qiong Yu
To date, the diagnosis of schizophrenia (SCZ) mainly relies on patients' or guardians' self-reports and clinical observation, and the pathogenesis of SCZ remains elusive. In this study, we sought to develop a reliable classifier for diagnosing SCZ patients and provide clues to the etiology and pathogenesis of SCZ. Based on the high throughput sequencing analysis of peripheral blood miRNA expression profile and weighted gene co-expression network analysis (WGCNA) in our previous study, we selected eleven hub miRNAs for validation by qRT-PCR in 51 SCZ patients and 51 controls...
January 29, 2023: Journal of Psychiatric Research