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ferritin newborn

Beata Kulik-Rechberger, Artur Kościesza, Elżbieta Szponar, Justyna Domosud
OBJECTIVES: The amount of iron is regulated by hepcidin. The aim of the study was to assess hepcidin concentrations in healthy pregnant women before delivery, in cord blood, and in 3-day-old newborns in relation to maternal and neonatal iron status. MATERIAL AND METHODS: The study group consisted of 44 mother-newborn pairs. Serum concentrations of hepcidin, ferritin, and transferrin receptor (sTfR) were assessed. RESULTS: Maternal hepcidin was significantly lower than cord blood (p < 0...
2016: Ginekologia Polska
Julie Sturza, Monica K Silver, Lin Xu, Mingyan Li, Xiaoqin Mai, Yankai Xia, Jie Shao, Betsy Lozoff, John Meeker
BACKGROUND: Pesticides are associated with poorer neurodevelopmental outcomes, but little is known about the effects on sensory functioning. METHODS: Auditory brainstem response (ABR) and pesticide data were available for 27 healthy, full-term 9-month-old infants participating in a larger study of early iron deficiency and neurodevelopment. Cord blood was analyzed by gas chromatography-mass spectrometry for levels of 20 common pesticides. The ABR forward-masking condition consisted of a click stimulus (masker) delivered via ear canal transducers followed by an identical stimulus delayed by 8, 16, or 64 milliseconds (ms)...
July 2016: Environment International
Marjana Jerković Raguž, Jerko Brzica
Objective The objective of this study was to determine the effect of body mass index (BMI) during pregnancy in laboratory parameters in the serum of the three groups of pregnant women and in their newborns. Methods This prospective study is comparison between the three groups of pregnant women and their newborns categorized according to their BMI. The study included 128 pregnant women and their newborns. In this study, the concentration of blood count, iron, ferritin, and bilirubin were analyzed in the subjects...
April 2016: American Journal of Perinatology Reports
T N Pogorelova, V A Linde, V O Gunko, S N Selyutina
The levels of zinc, copper, iron, and magnesium ions, and some of their binding proteins have been investigated in an amniotic fluid under the fetal growth retardation (FGR). FGR, developed under conditions of placental insufficiency, is characterized by a decrease in the content of zinc, iron, and magnesium ions and by an increase in the copper content in the amniotic fluid in the II and III trimesters of pregnancy. During these trimesters the levels of ceruloplasmin, ferritin, and Ca2+,Mg2+-ATPase were lower in FGR, while the level of zinc-a-2-glycoprotein was higher than during the same periods of normal pregnancy...
January 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
Natalie C Dosch, Elyssa F Guslits, Morgan B Weber, Shannon E Murray, Barbara Ha, Christopher L Coe, Anthony P Auger, Pamela J Kling
OBJECTIVE: To determine the impact of maternal obesity and gestational weight gain across pregnancy on fetal indices of inflammation and iron status. STUDY DESIGN: Eighty-five healthy term newborns delivered via elective cesarean were categorized by 2 maternal body mass index (BMI) thresholds; above or below 30 kg/m(2) or above or below 35 kg/m(2). Umbilical cord plasma levels of C-reactive protein, interleukin (IL)-6, tumor necrosis factor (TNF)-α, ferritin, and hepcidin were assayed...
May 2016: Journal of Pediatrics
L Korkmaz, O Baştuğ, G Daar, S Doğanay, K Deniz, S Kurtoğlu
Neonatal hemochromatosis (NH) is a form of neonatal liver failure caused by maternal-fetal alloimmune injury to hepatocytes. The etiology of neonatal hemochromatosis is not exactly understood. However, according to one theory neonatal hemochromatosis is believed to be an alloimmune disorder causing liver injury in the fetus. In order to diagnose neonatal hemochromatosis there are some criteria that should be taken into account, such as positive family history, high serum ferritin levels, high serum alpha-fetoprotein levels and siderosis demonstrated by histology or with magnetic resonance...
2015: Journal of Neonatal-perinatal Medicine
R K Chandyo, S Henjum, M Ulak, A L Thorne-Lyman, R J Ulvik, P S Shrestha, L Locks, W Fawzi, T A Strand
BACKGROUND/OBJECTIVES: Iron deficiency anemia is a widespread public health problem, particularly in low- and middle-income countries. Maternal iron status around and during pregnancy may influence infant iron status. We examined multiple biomarkers to determine the prevalence of iron deficiency and anemia among breastfed infants and explored its relationship with maternal and infant characteristics in Bhaktapur, Nepal. SUBJECTS/METHODS: In a cross-sectional survey, we randomly selected 500 mother-infant pairs from Bhaktapur municipality...
April 2016: European Journal of Clinical Nutrition
Catherine Monk, Michael K Georgieff, Dongrong Xu, Xuejun Hao, Ravi Bansal, Hanna Gustafsson, Julie Spicer, Bradley S Peterson
BACKGROUND: Children prenatally exposed to inadequate iron have poorer motor and neurocognitive development. No prior study to our knowledge has assessed the influence of maternal prenatal iron intake on newborn brain tissue organization in full-term infants. METHODS: Third trimester daily iron intake was obtained using the Automated Self-Administered 24-h Dietary Recall with n = 40 healthy pregnant adolescents (aged 14-19 y). Cord blood ferritin was collected in a subsample (n = 16)...
March 2016: Pediatric Research
Solange Augusta de Sá, Erica Willner, Tatiane Aguiar Duraes Pereira, Vanessa Rosse de Souza, Gilson Teles Boaventura, Vilma Blondet de Azeredo
INTRODUCTION: nutritional deficiencies are still a common problem during pregnancy causing anemia. Gestational anemia is still considered a public health problem in Brazil, because it is hazardous to both mother and fetus, and is associated with increased risk of maternal-fetal morbidity, as well as the nutritional status of child. OBJECTIVE: to evaluate the frequency of maternal gestational anemia in newborns and its relation to the nutritional status of the child at birth...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Gabriel López-Velázquez, Minerva Parra-Ortiz, Ignacio De la Mora-De la Mora, Itzhel García-Torres, Sergio Enríquez-Flores, Miguel Angel Alcántara-Ortigoza, Ariadna González-Del Angel, José Velázquez-Aragón, Rosario Ortiz-Hernández, José Manuel Cruz-Rubio, Pablo Villa-Barragán, Carlos Jiménez-Gutiérrez, Pedro Gutiérrez-Castrellón
BACKGROUND: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health. Production of better prebiotics from endemic plants raises possibilities to enhance nutritional effects in vulnerable population groups. Fructans derived from Agave Plant have demonstrated their safety and efficacy as prebiotics in animal models. Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated...
November 2015: Nutrients
Sanoop Adathila Valappil, Miriam Varkey, Binu Areeckal, Krishnadas Thankan, Siva M D
BACKGROUND: Preterm birth is the leading cause of newborn deaths and also the leading cause of death in children under 5 years of age. There is wide spread suspicion that subclinical infection is a common accompaniment and cause of preterm labour. Ferritin is an acute phase reactant and it increases during inflammation.This study aims to determine whether serum ferritin levels which may be raised in the setting of any infective process could be used as a marker of spontaneous preterm labour or PPROM (Preterm premature rupture of membranes)...
July 2015: Journal of Clinical and Diagnostic Research: JCDR
Sunmin Lee, Ronnie Guillet, Elizabeth M Cooper, Mark Westerman, Mark Orlando, Tera Kent, Eva Pressman, Kimberly O O'Brien
BACKGROUND: Little is known about anemia and iron status in US newborns because screening for anemia is typically not undertaken until 1 y of age. This study was undertaken to characterize and identify determinants of iron status in newborns born to pregnant adolescents. METHODS: Pregnant adolescents (≤ 18 y, n = 193) were followed from ≥ 12 wk gestation until delivery. Hemoglobin, ferritin, soluble transferrin receptor, serum iron, hepcidin, erythropoietin (EPO), IL-6, and C-reactive protein were assessed in maternal and cord blood...
January 2016: Pediatric Research
Alper I Dai, Seniz Demiryürek, Sefika Nur Aksoy, Peren Perk, Oguzhan Saygili, Kivanc Güngör
BACKGROUND: Retinopathy of prematurity is a proliferative vascular disease affecting premature newborns and occurs during vessel development and maturation. The aim of this study was to evaluate the maternal iron deficiency anemia as possible risk factors associated with the development of retinopathy of prematurity among premature or very low birth weight infants. METHODS: In this study, mothers of 254 infants with retinopathy of prematurity were analyzed retrospectively, and their laboratory results of medical records during pregnancy were reviewed for possible iron deficiency anemia...
August 2015: Pediatric Neurology
Irina B Pateva, Elizabeth H Kerling, Manju Reddy, Dan Chen, Susan E Carlson, Jakica Tancabelic
BACKGROUND: Maternal smoking has been known to have a negative impact on the well being of the developing fetus. Prenatal smoking has been associated with premature births, low birth weight and with certain birth defects. Small research studies have also found a negative correlation between maternal smoking and neonatal body iron. OBJECTIVES: To study and compare the relationship between maternal and infants' body iron in smokers and non-smokers in a large matched-pair cohort...
2015: Clinical Research and Trials
A K Yadav, A Upadhyay, S Gothwal, K Dubey, U Mandal, C P Yadav
OBJECTIVE: To compare the effect of combined delayed cord clamping and umbilical cord milking to either of them had done alone, on hematological parameters at 6 weeks of age in term neonates. STUDY DESIGN: It was a randomized controlled trial, conducted during January to December 2014. Three hundred eligible neonates were randomly allocated to three parallel groups. Primary outcome was hemoglobin and serum ferritin at 6 weeks of age. Data were analyzed using analysis of variance and Kruskal-Wallis test...
September 2015: Journal of Perinatology: Official Journal of the California Perinatal Association
Gengli Zhao, Guobin Xu, Min Zhou, Yaping Jiang, Blair Richards, Katy M Clark, Niko Kaciroti, Michael K Georgieff, Zhixiang Zhang, Twila Tardif, Ming Li, Betsy Lozoff
BACKGROUND: Previous trials of prenatal iron supplementation had limited measures of maternal or neonatal iron status. OBJECTIVE: The purpose was to assess effects of prenatal iron-folate supplementation on maternal and neonatal iron status. METHODS: Enrollment occurred June 2009 through December 2011 in Hebei, China. Women with uncomplicated singleton pregnancies at ≤20 wk gestation, aged ≥18 y, and with hemoglobin ≥100 g/L were randomly assigned 1:1 to receive daily iron (300 mg ferrous sulfate) or placebo + 0...
August 2015: Journal of Nutrition
José Carlos Jaime-Pérez, Gisela García-Arellano, Nereida Méndez-Ramírez, Óscar González-Llano, David Gómez-Almaguer
OBJECTIVE: By applying receiver operating characteristic curve analysis, the objective of this study was to see whether hemoglobin levels reflect body iron stores in a group of pregnant women at term who, by using serum ferritin as the reference test, had a high pre-test probability of having iron deficiency anemia. Likewise, we evaluated the ability of hemoglobin and maternal serum ferritin levels to predict iron deficiency anemia in newborns. METHODS: Hemoglobin and serum ferritin were measured in 187 pregnant women at term belonging to a group with a high pre-test probability of iron deficiency anemia and their newborns...
May 2015: Revista Brasileira de Hematologia e Hemoterapia
Sibao Li, Yufeng Liu, Yumei Wang, Peihong Qi, Diao Wang
OBJECTIVE: To detect the concentration of serum hepcidin and the mRNA expression level of ferroportin1 (FPN1) in the placenta membrane from full term pregnant women with different degree of iron deficiency, and explore their roles for iron transport in placental. METHODS: The concentration of HGB, serum iron (SI) and serum ferritin (SF) of mothers and infants were detected in 55 full term pregnant women and neonates. The expression level of FPN1 mRNA in placental was detected by the RT-PCR technique...
April 2015: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
R Weigert, N C Dosch, M E Bacsik-Campbell, T W Guilbert, C L Coe, P J Kling
OBJECTIVE: Allergic disease is multifactorial in origin. Because iron nutrition affects immune responses and maternal pregnancy weight gain impairs fetal iron delivery while increasing fetal demands for growth, the study examined maternal pregnancy weight gain, newborn iron status and an index of atopic disease, infant eosinophilia. STUDY DESIGN: Within a larger prospective study of healthy newborns at risk for developing iron deficiency anemia, umbilical cord iron indicators were compared to infant eosinophil counts...
August 2015: Journal of Perinatology: Official Journal of the California Perinatal Association
Betelihem Terefe, Asaye Birhanu, Paulos Nigussie, Aster Tsegaye
Iron deficiency anemia among pregnant women is a widespread problem in developing countries including Ethiopia, though its influence on neonatal iron status was inconsistently reported in literature. This cross-sectional study was conducted to compare hematologic profiles and iron status of newborns from mothers with different anemia status and determine correlation between maternal and neonatal hematologic profiles and iron status in Ethiopian context. We included 89 mothers and their respective newborns and performed complete blood count and assessed serum ferritin and C-reactive protein levels from blood samples collected from study participants...
2015: Anemia
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