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https://www.readbyqxmd.com/read/29313987/variable-role-of-carotid-bodies-in-cardiovascular-responses-to-exercise-hypoxia-and-hypercapnia-in-spontaneously-hypertensive-rats
#1
Wioletta Pijacka, Pedro L Katayama, Helio C Salgado, Gisele S Lincevicius, Ruy R Campos, Fiona D McBryde, Julian F R Paton
The carotid body has recently emerged as a promising therapeutic target for treating cardiovascular disease, however the potential impact of carotid bodies removal on the dynamic cardiovascular responses to acute stressors such as exercise, hypoxia and hypercapnia in hypertension is an important safety consideration that has not been studied. We first validated a novel surgical approach to selectively resect the carotid bodies bilaterally (CBR) sparing the carotid sinus baroreflex. Second, we evaluated the impact of CBR on the cardiovascular responses to exercise, hypoxia and hypercapnia in the conscious, chronically instrumented spontaneously hypertensive (SH) rats...
January 5, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29310595/potential-of-dosr-and-rpf-antigens-from-mycobacterium-tuberculosis-to-discriminate-between-latent-and-active-tuberculosis-in-a-tuberculosis-endemic-population-of-medellin-colombia
#2
Leonar Arroyo, Diana Marín, Kees L M C Franken, Tom H M Ottenhoff, Luis F Barrera
BACKGROUND: Tuberculosis (TB) remains one of the most deadly infectious diseases. One-third to one-fourth of the human population is estimated to be infected with Mycobacterium tuberculosis (Mtb) without showing clinical symptoms, a condition called latent TB infection (LTBI). Diagnosis of Mtb infection is based on the immune response to a mixture of mycobacterial antigens (PPD) or to Mtb specific ESAT-6/CFP10 antigens (IGRA), highly expressed during the initial phase of infection. However, the immune response to PPD and IGRA antigens has a low power to discriminate between LTBI and PTB...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29310586/available-bed-sided-comprehensive-abc-score-to-a-diagnosis-of-methicillin-resistant-staphylococcus-aureus-infection-a-derivation-and-validation-study
#3
Nori Yoshioka, Matsuo Deguchi, Hideharu Hagiya, Hisao Yoshida, Norihisa Yamamoto, Shoji Hashimoto, Yukihiro Akeda, Kazunori Tomono
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) infections continue to be a leading problem in health care facilities worldwide. METHODS: This single-center retrospective cohort study consisted of a derivation phase and a validation phase. The derivation phase included all patients admitted to Osaka University Hospital between May 2010 and April 2011. We proposed a provisional available, bed-sided, comprehensive (ABC) score, and evaluated its accuracy using the clinical diagnosis as a reference...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29281044/radiobiological-response-of-u251mg-cho-k1-and-v79-cell-lines-to-accelerator-based-boron-neutron-capture-therapy
#4
Eisuke Sato, Alexander Zaboronok, Tetsuya Yamamoto, Kei Nakai, Sergey Taskaev, Olga Volkova, Ludmila Mechetina, Alexander Taranin, Vladimir Kanygin, Tomonori Isobe, Bryan J Mathis, Akira Matsumura
In the current article, we provide in vitro efficacy evaluation of a unique accelerator-based neutron source, constructed at the Budker Institute of Nuclear Physics (Novosibirsk, Russian Federation), for boron neutron capture therapy (BNCT), which is particularly effective in the case of invasive cancers. U251MG, CHO-K1 and V79 cells were incubated and irradiated in various concentrations of boric acid with epithermal neutrons for 2-3 h in a plexiglass phantom, using 2.0 MeV proton energy and 1.5-3.0 mA proton current, resulting in a neutron fluence of 2...
December 21, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29276975/non-tip-auditory-nerve-responses-that-are-suppressed-by-low-frequency-bias-tones-originate-from-reticular-lamina-motion
#5
Hui Nam, John J Guinan
Recent cochlear mechanical measurements show that active processes increase the motion response of the reticular lamina (RL) at frequencies more than an octave below the local characteristic frequency (CF) for CFs above 5 kHz. A possible correlate is that in high-CF (>5 kHz) auditory-nerve (AN) fibers, responses to frequencies 1-3 octaves below CF ("tail" frequencies) can be inhibited by medial olivocochlear (MOC) efferents. These results indicate that active processes enhance the sensitivity of tail-frequency RL and AN responses...
December 14, 2017: Hearing Research
https://www.readbyqxmd.com/read/29275255/weather-variables-and-the-el-ni%C3%A3-o-southern-oscillation-may-drive-the-epidemics-of-dengue-in-guangdong-province-china
#6
Jianpeng Xiao, Tao Liu, Hualiang Lin, Guanghu Zhu, Weilin Zeng, Xing Li, Bing Zhang, Tie Song, Aiping Deng, Meng Zhang, Haojie Zhong, Shao Lin, Shannon Rutherford, Xiaojing Meng, Yonghui Zhang, Wenjun Ma
OBJECTIVE: To investigate the periodicity of dengue and the relationship between weather variables, El Niño Southern Oscillation (ENSO) and dengue incidence in Guangdong Province, China. METHODS: Guangdong monthly dengue incidence and weather data and El Niño index information for 1988 to 2015 were collected. Wavelet analysis was used to investigate the periodicity of dengue, and the coherence and time-lag phases between dengue and weather variables and ENSO. The Generalized Additive Model (GAM) approach was further employed to explore the dose-response relationship of those variables on dengue...
December 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29260554/general-theoretical-treatment-of-ion-transfers-in-two-polarisable-interface-systems-when-the-analyte-has-access-to-both-interfaces
#7
José Manuel Olmos, Angela Molina, Eduardo Laborda, Enrique Millan-Barrios, Joaquín A Ortuño
A new theory is presented to tackle the study of transfer processes of hydrophilic ions in two polarisable interface systems when the analyte is initially present in both aqueous phases. The treatment is applied to macrointerfaces (linear diffusion) and microholes (highly convergent diffusion), obtaining analytical equations for the current response in any voltammetric technique. The novel equations predict two signals in the current-potential curves that are symmetric when the compositions of the aqueous phases are identical while asymmetries appear otherwise...
December 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29245829/sensitive-detection-of-voltage-transients-using-differential-intensity-surface-plasmon-resonance-system
#8
Sidahmed A Abayzeed, Richard J Smith, Kevin F Webb, Michael G Somekh, Chung W See
This paper describes theoretical and experimental study of the fundamentals of using surface plasmon resonance (SPR) for label-free detection of voltage. Plasmonic voltage sensing relies on the capacitive properties of metal-electrolyte interface that are governed by electrostatic interactions between charge carriers in both phases. Externally-applied voltage leads to changes in the free electron density in the surface of the metal, shifting the SPR position. The study shows the effects of the applied voltage on the shape of the SPR curve...
December 11, 2017: Optics Express
https://www.readbyqxmd.com/read/29245798/support-vector-machine-assisted-botda-utilizing-combined-brillouin-gain-and-phase-information-for-enhanced-sensing-accuracy
#9
Huan Wu, Liang Wang, Nan Guo, Chester Shu, Chao Lu
Benefiting from both Brillouin amplitude and phase spectral responses during Brillouin scattering, a support vector machine (SVM) assisted Brillouin optical time domain analyzer (BOTDA) enabling the improvement of sensing accuracy with only a slight sacrifice of processing speed has been proposed and demonstrated. Only one SVM model, i.e. SVM-(g + p), is required to effectively combine the Brillouin gain and phase information in the training and testing phases, which avoids separate Brillouin gain spectrum (BGS) and Brillouin phase spectrum (BPS) fitting, and hence saves the processing time...
December 11, 2017: Optics Express
https://www.readbyqxmd.com/read/29244089/the-historical-progression-from-adl-scrutiny-to-iadl-to-advanced-adl-assessing-functional-status-in-the-earliest-stages-of-dementia
#10
Robert Fieo, Laura Zahodne, Ming X Tang, Jennifer J Manly, Ron Cohen, Yaakov Stern
Background: Decrements in instrumental activities (IADL) have been observed in the prodromal phase of dementia. Given the long pre-dementia stage in neuro-degenerative diseases, it has been proposed that subtle functional changes may precede clinical IADL impairment. Incorporating more challenging advanced ADLs (e.g., volunteer work) into the assessment process may increase the sensitivity of functional measures, thus expanding the window for monitoring or interventions. Methods: Longitudinal cohort study (follow-ups, 18-24 month), subjects aged >60 (n=3635)...
December 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29240996/transfer-mechanism-uptake-kinetic-process-and-bioavailability-of-p-cu-cd-pb-and-zn-in-macrophyte-rhizosphere-using-dgt
#11
Shengrui Wang, Zhihao Wu, Jun Luo
The transfer-uptake-bioavailability of phosphorus (P), Cu, Cd, Zn and Pb in rhizosphere of Zizania latifolia (ZL) and Myriophyllum verticiilaturn (MV) cultivated in rhizoboxes in Lake Erhai (China) is investigated by DGT (diffusive gradients in thin films) technique. DGT induced fluxes in sediments (DIFS) model reveals that resupply ability (r), liable pool size in sediment solid (kd), kinetic parameter (k-1) or response time (Tc) control the diffusion-resupply characters of P and Cu (standing for four metals) in rhizosphere interface...
December 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29238274/hormetic-response-by-silver-nanoparticles-on-in-vitro-multiplication-of-sugarcane-saccharum-spp-cv-mex-69-290-using-a-temporary-immersion-system
#12
Jericó J Bello-Bello, Rocío A Chavez-Santoscoy, Carlos A Lecona-Guzmán, Nina Bogdanchikova, Josafhat Salinas-Ruíz, Fernando Carlos Gómez-Merino, Alexey Pestryakov
Background: Hormesis is considered a dose-response phenomenon characterized by growth stimulation at low doses and inhibition at high doses. The hormetic response by silver nanoparticles (AgNPs) on in vitro multiplication of sugarcane was evaluated using a temporary immersion system. Methods: Sugarcane shoots were used as explants cultured in Murashige and Skoog medium with AgNPs at concentrations of 0, 25, 50, 100, and 200 mg/L. Shoot multiplication rate and length were used to determine hormetic response...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29235121/a-simple-and-rapid-hplc-uv-method-for-the-determination-of-retigabine-in-human-plasma
#13
Valentina Franco, Katia Baruffi, Giuliana Gatti, Roberto Marchiselli, Cinzia Fattore, Maria Paola Canevini, Francesca Crema, Emilio Perucca
A simple and rapid high-performance liquid chromatographic method with ultraviolet detection was developed for the quantitative determination of retigabine, known also as ezogabine, in human plasma. The assay uses a simple solid phase extraction for sample preparation and direct injection of the extract into the chromatograph. Flupirtine is used as an internal standard. Chromatographic separation is achieved on a C18 Chromolith column (Chromolith Performance, 100 x 4.6 mm ID), using as mobile phase water/acetonitrile/methanol (72:18:10 vol/vol/vol) mixed with 0...
December 12, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29232899/a-dual-butterfly-structure-gyroscope
#14
Xiangming Xu, Dingbang Xiao, Wenyin Li, Qiang Xu, Zhanqiang Hou, Xuezhong Wu
This paper reports a dual-butterfly structure gyroscope based on the traditional butterfly structure. This novel structure is composed of two butterfly structures, each of which contains a main vibrational beam, four proof masses, and a coupling mechanism. The coupling mechanism in this proposed structure couples the two single butterfly structures and keeps the driving mode phases of the two single butterfly gyroscopes exactly opposite, increasing the double difference of traditional butterfly gyroscopes to a quad difference, which has the potential advantage of improving bias instability and g-sensitivity...
December 11, 2017: Sensors
https://www.readbyqxmd.com/read/29232610/electrospun-polydimethylsiloxane-polyacrylonitrile-titanium-dioxide-nanofibers-as-a-new-coating-for-determination-of-alpha-linolenic-acid-in-milk-by-direct-immersion-solid-phase-nanoextraction
#15
Sahar Sadeghi, Afsaneh Mollahosseini
In this study, polydimethylsiloxane/polyacrylonitrile/titanium dioxide (PDMS/PAN/TiO2) nanofibers were synthesized via electrospinning method to extract and quantify alpha-linolenic acid (ALA, C18:3), as a model analyte, in milk by direct immersion-solid phase nanoextraction (DI-SPNE) with gas chromatography-flame ionization detector (GC-FID). The affecting factors on the electrospinning process such as, PDMS concentration, amount of TiO2 nanoparticles (NPs), voltage, and electrospinning distance were optimized using Taguchi's orthogonal design...
December 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29228043/novel-systems-for-the-application-of-isolated-tensile-compressive-and-shearing-stimulation-of-distraction-callus-tissue
#16
Nicholaus Meyers, Julian Schülke, Anita Ignatius, Lutz Claes
BACKGROUND: Distraction osteogenesis is a procedure widely used for the correction of large bone defects. However, a high complication rate persists, likely due to insufficient stability during maturation. Numerical fracture healing models predict bone regeneration under different mechanical conditions allowing fixation stiffness optimization. However, most models apply a linear elastic material law inappropriate for the transient stresses/strains present during limb lengthening or segment transport...
2017: PloS One
https://www.readbyqxmd.com/read/29226849/assessment-of-global-and-local-region-based-bilateral-mammographic-feature-asymmetry-to-predict-short-term-breast-cancer-risk
#17
Yane Li, Ming Fan, Hu Cheng, Peng Zhang, Bin Zheng, Lihua Li
This study aims to develop and test a new imaging marker-based short-term breast cancer risk prediction model. An age-matched dataset of 566 screening mammography cases was used. All "prior" images acquired in the two screening series were negative, while in the "current" screening images, 283 cases were positive for cancer and 283 cases remained negative. For each case, two bilateral cranio-caudal view mammograms acquired from the "prior" negative screenings were selected and processed by a computer-aided image processing scheme, which segmented the entire breast area into 9 strip-based local regions, extracted the element regions using difference of Gaussian filters, and computed both global- and local-based bilateral asymmetrical image features...
December 11, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29225263/a-phase-i-ii-study-for-dose-finding-and-to-investigate-the-safety-pharmacokinetics-and-preliminary-efficacy-of-nk012-an-sn-38-incorporating-macromolecular-polymeric-micelle-in-patients-with-multiple-myeloma
#18
Masaki Ri, Kenshi Suzuki, Shinsuke Iida, Kiyohiko Hatake, Takaaki Chou, Masafumi Taniwaki, Noriko Watanabe, Tetsuji Tsukamoto
Objective Multiple myeloma (MM) is the second most common hematological cancer. An attempt to treat MM using a topoisomerase I inhibitor was made based on our previous non-clinical studies suggesting the usefulness of an SN-38 derivative. Our aim was to conduct a phase I/II study of NK012, a micelle-forming SN-38 conjugate, in patients with relapsed/refractory multiple myeloma (RRMM). Methods NK012 was administered at doses of 12-24 mg/m2 and the safety, pharmacokinetics and preliminary efficacy were evaluated...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29225091/gene-expression-profiling-of-the-trim-protein-family-reveals-potential-biomarkers-for-indicating-tuberculosis-status
#19
Yanqing Chen, Shuhui Cao, Yong Sun, Chuanyou Li
Tripartite motif (TRIM) family proteins play important regulatory roles in innate immune responses, the dysregulation of which cause several infectious diseases. However, the role and function of TRIM family proteins during tuberculosis (TB) infection remains unclear. In this study, we employed real-time quantitative PCR to profile the transcript levels of 72 TRIM genes from a cohort of 5 active TB patients, 5 latent tuberculosis infection (LTBI) subjects, and 5 healthy controls (HCs) in an initial discovery phase...
December 7, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29219220/heart-rate-recovery-fast-to-slow-phase-transition-influence-of-physical-fitness-and-exercise-intensity
#20
Rhenan Bartels, Eliza Prodel, Mateus C Laterza, Jorge Roberto P de Lima, Tiago Peçanha
BACKGROUND: Postexercise heart rate (HR) recovery presents an exponential decay, with two distinct phases: a fast phase, characterized by abrupt decay of HR, and determined by parasympathetic reactivation; and a slow phase, characterized by gradual decay of HR, and predominantly determined by sympathetic withdrawal. Although several methods have been proposed to assess postexercise HR recovery, none of those methods selectively assesses the time of transition from the fast to the slow phase of the HR recovery curve (HRRPT ), and the magnitude of decay prior to (HRRFP ) and after this point (HRRSP )...
December 8, 2017: Annals of Noninvasive Electrocardiology
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