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https://www.readbyqxmd.com/read/27933441/multimodality-imaging-to-assess-immediate-response-following-irreversible-electroporation-in-patients-with-malignant-hepatic-tumors
#1
Katsutoshi Sugimoto, Fuminori Moriyasu, Kazuhiro Saito, Yoshiyuki Kobayashi, Takao Itoi
PURPOSE: To assess the diagnostic accuracy of contrast-enhanced ultrasound (CEUS), contrast-enhanced multiphase CT (CECT), and gadoxetic acid-enhanced MRI (EOB-MRI) in identifying residual tumor in the subacute follow-up of patients with malignant hepatic tumors treated by irreversible electroporation (IRE). METHODS: We enrolled 16 patients with 21 hepatic lesions treated by IRE and examined by CEUS and CECT at 1 day after IRE and by EOB-MRI at 7 days after IRE...
December 8, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27933333/discriminatory-ability-of-simple-ogtt-based-beta-cell-function-indices-for-prediction-of-prediabetes-and-type-2-diabetes-the-codam-study
#2
Louise J C J den Biggelaar, Simone J S Sep, Simone J P M Eussen, Andrea Mari, Ele Ferrannini, Marleen M J van Greevenbroek, Carla J H van der Kallen, Casper G Schalkwijk, Coen D A Stehouwer, Pieter C Dagnelie
AIMS/HYPOTHESIS: The hyperglycaemic clamp technique and the frequently sampled IVGTT are unsuitable techniques to assess beta cell function (BCF) in large cohorts. Therefore, the aim of this study was to evaluate the discriminatory ability of simple OGTT-based BCF indices for prediction of prediabetes (meaning impaired fasting glucose and/or impaired glucose tolerance) and type 2 diabetes. METHODS: Glucose metabolism status was assessed by 2 h 75 g OGTT at baseline (n = 476, mean age 59...
December 8, 2016: Diabetologia
https://www.readbyqxmd.com/read/27929070/all-dielectric-ultrathin-conformal-metasurfaces-lensing-and-cloaking-applications-at-532%C3%A2-nm-wavelength
#3
Jierong Cheng, Samad Jafar-Zanjani, Hossein Mosallaei
Metasurfaces are ideal candidates for conformal wave manipulation on curved objects due to their low profiles and rich functionalities. Here we design and analyze conformal metasurfaces for practical optical applications at 532 nm visible band for the first time. The inclusions are silicon disk nanoantennas embedded in a flexible supporting layer of polydimethylsiloxane (PDMS). They behave as local phase controllers in subwavelength dimensions for successful modification of electromagnetic responses point by point, with merits of high efficiency, at visible regime, ultrathin films, good tolerance to the incidence angle and the grid stretching due to the curvy substrate...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928714/phase-i-study-of-nivolumab-an-anti-pd-1-antibody-in-patients-with-malignant-solid-tumors
#4
Noboru Yamamoto, Hiroshi Nokihara, Yasuhide Yamada, Takashi Shibata, Yosuke Tamura, Yoshitaka Seki, Kazunori Honda, Yuko Tanabe, Hiroshi Wakui, Tomohide Tamura
Background This study evaluated the safety, tolerability, pharmacokinetics, immunogenicity and antitumor activity of single and multiple doses of nivolumab in Japanese patients with malignant solid tumors. Subjects and Methods This was an open-label, dose-escalation study in 17 patients with advanced solid tumors with a life expectancy of ≥3 months. Patients were observed for 3 weeks after a single dose of nivolumab at 1, 3, 10 or 20 mg/kg, then received the same dose of nivolumab every 2 weeks until unacceptable toxicity or disease progression occurred...
December 8, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27927864/efficacy-and-safety-of-praziquantel-against-light-infections-of-opisthorchis-viverrini-a-randomised-parallel-single-blind-dose-ranging-trial
#5
Somphou Sayasone, Isabel Meister, Jason R Andrews, Peter Odermatt, Youthanavanh Vonghachack, Syda Xayavong, Kanpaseuth Senggnam, Khampheng Phongluxa, Jan Hattendorf, Isaac I Bogoch, Jennifer Keiser
BACKGROUND: The liver fluke Opisthorchis viverrini, highly prevalent in Southeast Asia, is an important public health burden, including a risk factor for developing an aggressive bile duct cancer, cholangiocarcinoma, in chronically infected patients. Praziquantel, administered at single 40 mg/kg in preventive chemotherapy programs and 3 x 25 mg/kg for individual treatment is the drug of choice, yet information on the nature of the dose-response relationship is lacking. METHODS: We performed a randomized, parallel, single blind dose-ranging Phase 2 trial in Lao PDR in O...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27925676/population-pharmacokinetics-and-exposure-response-relationship-of-carfilzomib-in-patients-with-multiple-myeloma
#6
Ying Ou, Sameer Doshi, Anh Nguyen, Fredrik Jonsson, Sanjay Aggarwal, Kanya Rajangam, Meletios A Dimopoulos, A Keith Stewart, Ashraf Badros, Kyriakos P Papadopoulos, David Siegel, Sundar Jagannath, Ravi Vij, Ruben Niesvizky, Richard Graham, Jenn Visich
A population pharmacokinetic (PK) model and exposure-response (E-R) analysis was developed using data collected from 5 phase 1b/2 and 2 phase 3 studies in subjects with multiple myeloma. Subjects receiving intravenous infusion on 2 consecutive days each week for 3 weeks (days 1, 2, 8, 9, 15, and 16) in each cycle at doses ranging from 15 to 20/56 mg/m(2) (20 mg/m(2) in cycle 1 and, if tolerated, escalated to 56 mg/m(2) on day 8 of cycle 1). The population PK analysis indicated that among all the covariates tested, the only statistically significant covariate was body surface area on carfilzomib clearance; however, this covariate was unlikely to be clinically significant...
December 7, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27920527/pharmacokinetics-and-safety-of-dts-108-a-human-oligopeptide-bound-to-sn-38-with-an-esterase-sensitive-cross-linker-in-patients-with-advanced-malignancies-a-phase-i-study
#7
Romain Coriat, Sandrine J Faivre, Olivier Mir, Chantal Dreyer, Stanislas Ropert, Mohammed Bouattour, Robert Desjardins, François Goldwasser, Eric Raymond
BACKGROUND: DTS-108 is a hydrosoluble prodrug, where the SN-38 moiety is covalently linked to a 20-amino acid vector peptide by a specific esterase-sensitive cross-linker, releasing 7-ethyl-10-hydroxycampthotecin (SN-38) by esterase bond cleavage. METHODS: The pharmacokinetics of DTS-108, adverse events graded according to NCI-CTCv3.1, dose-limiting toxicities at cycle 1, the maximum tolerated dose (MTD), and the recommended Phase II dose (RP2D) of intravenous DTS-108 (1-2 hours) every 2 weeks were evaluated in a first-in-human Phase I study in patients with advanced/metastatic carcinomas, according to an accelerated dose escalation design...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27920513/bronchodilator-efficacy-of-18-%C3%AE-g-once-daily-tiotropium-inhalation-via-discair-%C3%A2-versus-handihaler-%C3%A2-in-adults-with-chronic-obstructive-pulmonary-disease-randomized-active-controlled-parallel-group-open-label-phase-iv-trial
#8
Pinar Yildiz, Mesut Bayraktaroglu, Didem Gorgun, Funda Secik
PURPOSE: To compare the bronchodilator efficacy of 18 μg once-daily tiotropium inhalation administered via Discair(®) versus HandiHaler(®) in adults with moderate-to-severe chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS: Fifty-eight patients with moderate-to-severe COPD were enrolled in this randomized, active-controlled, parallel-group, open-label, Phase IV non-inferiority trial. Patients were randomly assigned to a test group (n=29, inhalation with Discair) or a reference group (n=29, inhalation with HandiHaler)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27918173/the-development-validation-and-feasibility-of-the-experienced-coercion-scale
#9
Olav Nyttingnes, Jorun Rugkåsa, Aina Holmén, Torleif Ruud
Existing scales for experienced coercion have limitations. We developed and validated a short self-report form for experienced coercion for use across care settings, care phases, and care measures. In Stage 1, we developed an item pool, based on the literature, patient accounts, interviews, and expert feedback. Stages 2 and 3 consisted of 2 cross-sectional studies, with patients from acute and nonacute inpatient wards, outpatient care, and supported housing. In Stage 2, patients (N = 212) responded to the Coercion Ladder and the experienced coercion items from Stage 1...
December 5, 2016: Psychological Assessment
https://www.readbyqxmd.com/read/27914349/effects-of-clay-minerals-hydroxides-and-timing-of-dissolved-organic-matter-addition-on-the-competitive-sorption-of-copper-nickel-and-zinc-a-column-experiment
#10
Yasser Refaey, Boris Jansen, John R Parsons, Pim de Voogt, Simone Bagnis, Adriaan Markus, Abdel-Hamid El-Shater, Abdel-Aziz El-Haddad, Karsten Kalbitz
Infiltration of heavy metal (HM) polluted wastewater can seriously compromise soil and groundwater quality. Interactions between mineral soil components (e.g. clay minerals) and dissolved organic matter (DOM) play a crucial role in determining HM mobility in soils. In this study, the influence of the timing of addition of DOM, i.e. concurrent with or prior to HMs, on HM mobility was explored in a set of continuous flow column experiments using well defined natural soil samples amended with goethite, birnessite and/or smectite...
November 30, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27911268/texture-analysis-of-intermediate-advanced-hepatocellular-carcinoma-prognosis-and-patients-selection-of-transcatheter-arterial-chemoembolization-and-sorafenib
#11
Sirui Fu, Shuting Chen, Changhong Liang, Zaiyi Liu, Yanjie Zhu, Yong Li, Ligong Lu
Transcatheter arterial chemoembolization (TACE) and sorafenib combination treatment for unselected hepatocellular carcinoma (HCC) is controversial. We explored the potential of texture analysis for appropriate patient selection. There were 261 HCCs included (TACE group: n = 197; TACE plus sorafenib (TACE+Sorafenib) group n = 64). We applied a Gabor filter and wavelet transform with 3 band-width responses (filter 0, 1.0, and 1.5) to portal-phase computed tomography (CT) images of the TACE group. Twenty-one textural parameters per filter were extracted from the region of interests delineated around tumor outline...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27909995/solithromycin-a-novel-fluoroketolide-for-the-treatment-of-community-acquired-bacterial-pneumonia
#12
REVIEW
George G Zhanel, Erika Hartel, Heather Adam, Sheryl Zelenitsky, Michael A Zhanel, Alyssa Golden, Frank Schweizer, Bala Gorityala, Philippe R S Lagacé-Wiens, Andrew J Walkty, Alfred S Gin, Daryl J Hoban, Joseph P Lynch, James A Karlowsky
Solithromycin is a novel fluoroketolide developed in both oral and intravenous formulations to address increasing macrolide resistance in pathogens causing community-acquired bacterial pneumonia (CABP). When compared with its macrolide and ketolide predecessors, solithromycin has several structural modifications which increase its ribosomal binding and reduce its propensity to known macrolide resistance mechanisms. Solithromycin, like telithromycin, affects 50S ribosomal subunit formation and function, as well as causing frame-shift errors during translation...
December 1, 2016: Drugs
https://www.readbyqxmd.com/read/27898845/effect-of-sterilization-and-of-dietary-fat-and-carbohydrate-content-on-food-intake-activity-level-and-blood-satiety-related-hormones-in-female-dogs
#13
S Schauf, A Salas-Mani, C Torre, G Bosch, H Swarts, C Castrillo
Animal sterilization is suggested to promote food overconsumption, although it is unknown whether this effect is mediated by variations in satiety-related hormones, which are released in response to food intake. The aim of this study was to evaluate the effect of sterilization and of the main energy-delivery nutrients, fat and nonstructural carbohydrates, on food intake, blood concentration of satiety-related hormones, and activity level in dogs. In a 2-phase experiment (phase I [Ph.I], 74 d, and Ph.II, 84 d), 12 female Beagle dogs were assigned to a control group (intact in both phases) and a sterilization group (spayed 20 d before Ph...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27891225/unraveling-the-role-of-preexisting-immunity-in-prostate-cancer-patients-vaccinated-with-a-her-2-neu-hybrid-peptide
#14
Ioannis F Voutsas, Eleftheria A Anastasopoulou, Panagiotis Tzonis, Michael Papamichail, Sonia A Perez, Constantin N Baxevanis
BACKGROUND: Cancer vaccines aim at eliciting not only an immune response against specific tumor antigens, but also at enhancing a preexisting immunity against the tumor. In this context, we recently reported on the levels of preexisting immunity in prostate cancer patients vaccinated with the HER-2 hybrid peptide (AE37), during a phase I clinical trial. The purpose of the current study was to correlate between preexisting immunity to the native HER-2 peptide, AE36, and expression of HLA-A2 and -A24 molecules with the clinical outcome...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27891096/systematic-characterization-of-dynamic-parameters-of-intracellular-calcium-signals
#15
Laurent Mackay, Nicholas Mikolajewicz, Svetlana V Komarova, Anmar Khadra
Dynamic processes, such as intracellular calcium signaling, are hallmark of cellular biology. As real-time imaging modalities become widespread, a need for analytical tools to reliably characterize time-series data without prior knowledge of the nature of the recordings becomes more pressing. The goal of this study is to develop a signal-processing algorithm for MATLAB that autonomously computes the parameters characterizing prominent single transient responses (TR) and/or multi-peaks responses (MPR). The algorithm corrects for signal contamination and decomposes experimental recordings into contributions from drift, TRs, and MPRs...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27890854/association-between-low-trough-levels-of-vedolizumab-during-induction-therapy-for-inflammatory-bowel-diseaseswith-need-for-additional-doses-within-6-months
#16
Nicolas Williet, Gilles Boschetti, Marion Fovet, Thomas Di Bernado, Pierre Claudez, Emilie Del Tedesco, Camille Jarlot, Leslie Rinaldi, Anne Berger, Jean-Marc Phelip, Bernard Flourie, Stéphane Nancey, Stéphane Paul, Xavier Roblin
BACKGROUND & AIMS: We investigated whether serum trough levels of vedolizumab, a humanized monoclonal antibody against integrin alpha 4 beta 7, during the induction phase of treatment can determine whether patients will need additional doses (optimization of therapy) within the first 6 months. METHODS: We conducted an observational study of 47 consecutive patients with Crohn's disease (CD; n=31) or ulcerative colitis (UC; n=16) who had not responded to 2 previous treatment regimens with antagonists of tumor necrosis factor and were starting therapy with vedolizumab at 2 hospitals in France, from June 2014 through April 2016...
November 24, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27889173/variability-in-the-adaptive-acid-tolerance-response-phenotype-of-salmonella-enterica-strains
#17
Alexandra Lianou, George-John E Nychas, Konstantinos P Koutsoumanis
The objective of this study was the assessment of the stationary-phase, low-pH-inducible acid tolerance response (ATR) of different Salmonella enterica strains. For this purpose, 30 strains of the pathogen were grown in tryptone soy broth in the absence (non-adapted cultures) and presence (1% w/v; acid-adapted cultures) of glucose, and then subjected to 4-h acid challenge trials at pH 3.0. Surviving populations of each strain were determined at 1-h intervals, and the Weibull model was fitted to the derived microbiological data...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27887037/failure-of-crp-decline-within-three-days-of-hospitalization-is-associated-with-poor-prognosis-of-community-acquired-pneumonia
#18
Stine Bang Andersen, Gertrud Baunbæk Egelund, Andreas Vestergaard Jensen, Pelle Trier Petersen, Gernot Rohde, Pernille Ravn
BACKGROUND: C-reactive protein (CRP) is a well-known acute phase protein used to monitor the patient's response during treatment in infectious diseases. Mortality from Community-acquired Pneumonia (CAP) remains high, particularly in hospitalized patients. Better risk prediction during hospitalization could improve management and ultimately reduce mortality levels. The aim of this study was to evaluate CRP on the 3rd day (CRP3) of hospitalization as a predictor for 30 days mortality. METHODS: A retrospective multicentre cohort study of adult patients admitted with CAP at three Danish hospitals...
November 25, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27886525/development-and-assays-estradiol-equivalent-concentration-from-prawn-p-eeq-in-river-prawn-macrobrachium-nipponense-in-taiwan
#19
Yuh-Wen Chiu, Fang-Ling Yeh, Bao-Sen Shieh, Chien-Min Chen, Hong-Thih Lai, Shu-Yin Wang, Da-Ji Huang
The present study established a fast and convenient bioassay method for aqueous ecosystems using the prawn estradiol equivalent concentration (p-EEQ) of male Macrobrachium nipponense, which produce vitellogenin (VTG) after exposure to xeno-estrogens. This method was then used to determine the concentrations of xeno-estrogen pollutants in the rivers of Taiwan. To establish the calibration curve for the concentrations based on the p-EEQ, the induced VTG content was determined using the alkali-labile phosphate method after male M...
November 22, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27885811/17-%C3%AE-estradiol-inhibits-hepatitis-c-virus-mainly-by-interference-with-the-release-phase-of-its-life-cycle
#20
Andrea Magri, Matteo N Barbaglia, Chiara Z Foglia, Elisa Boccato, Michela E Burlone, Sarah Cole, Paola Giarda, Elena Grossini, Arvind H Patel, Rosalba Minisini, Mario Pirisi
BACKGROUND & AIMS: Oestrogen and oestrogen-mediated signalling protect from hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain which phase(s) of hepatitis C virus life cycle is/are affected by oestrogens. METHODS: Huh7 cells infected with the JFH1 virus (genotype 2a) were exposed to dehydroepiandrosterone, testosterone, progesterone and 17β-estradiol (tested with/without its receptor antagonist fulvestrant). Dose-response curves were established to calculate half maximal inhibitory concentration values...
November 7, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
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