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https://www.readbyqxmd.com/read/29776536/rapid-profiling-and-quantification-of-phospholipid-molecular-species-in-human-plasma-based-on-chemical-derivatization-coupled-with-electrospray-ionization-tandem-mass-spectrometry
#1
Fang Wei, Xiang Wang, Hui-Fang Ma, Xin Lv, Xu-Yan Dong, Hong Chen
In this study, we developed a novel strategy using solid-phase extraction (SPE) coupled with shotgun mass spectrometry (MS) based on trimethylsilyldiazomethane (TMSCHN2 ) stable-isotope derivatization for rapid profiling and accurate quantification of phospholipids (PLs) in human plasma. HybridSPE-Phospholipid (HybridSPE-PL, zirconia coated silica stationary phase) was used for sample pretreatment via the Lewis acid-base interaction between zirconia and phosphate moiety of PLs. This step allows rapid enrichment and recovery of PLs from human plasma...
September 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29776095/optimal-entrainment-of-circadian-clocks-in-the-presence-of-noise
#2
Michele Monti, David K Lubensky, Pieter Rein Ten Wolde
Circadian clocks are biochemical oscillators that allow organisms to estimate the time of the day. These oscillators are inherently noisy due to the discrete nature of the reactants and the stochastic character of their interactions. To keep these oscillators in sync with the daily day-night rhythm in the presence of noise, circadian clocks must be coupled to the dark-light cycle. In this paper, we study the entrainment of phase oscillators as a function of the intrinsic noise in the system. Using stochastic simulations, we compute the optimal coupling strength, intrinsic frequency, and shape of the phase-response curve, that maximize the mutual information between the phase of the clock and time...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29773342/sol-gel-electrospinning-preparation-of-hybrid-carbon-silica-nanofibers-for-extracting-organophosphorus-pesticides-prior-to-analyzing-them-by-gas-chromatography-ion-mobility-spectrometry
#3
Mohammad T Jafari, Mohammad Saraji, Mansoure Kermani
Carbon-silica hybrid nanofibers as high performance coatings for solid-phase microextraction fibers were used for analyzing some pesticides by using gas chromatography-corona discharge ion mobility spectrometry. To that end, the fibers were prepared by carbonizing sol-gel based on electrospun polyacrylonitrile and tetraethyl orthosilicate nanofibers as carbon and silica precursors, respectively. Different parameters affecting the electrospinning and the extraction processes including spinning distance, voltage, feeding rate, stirring rate, salt concentration, temperature and extraction time were optimized by response surface methodology...
May 8, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29773341/a-full-solution-for-multi-component-quantification-oriented-quality-assessment-of-herbal-medicines-chinese-agarwood-as-a-case
#4
Huixia Huo, Yao Liu, Wenjing Liu, Jing Sun, Qian Zhang, Yunfang Zhao, Jiao Zheng, Pengfei Tu, Yuelin Song, Jun Li
The quality of herbal medicines (HMs) is the prerequisite for their pronounced therapeutic outcomes in clinic, and multi-component (also known as quality markers, Q-markers) quantification has been widely emphasized as a viable means for quality evaluation. Because of the chemical diversity, the quality control practices are extensively dampened by four principal technical bottlenecks, including the lack of authentic compounds, large polarity span, extensive concentration range, and signal misrecognition for those potential Q-markers...
May 9, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29773191/anti-inflammatory-and-antinociceptive-effects-of-2-2-dipyridyl-diselenide-through-reduction-of-inducible-nitric-oxide-synthase-nuclear-factor-kappa-b-and-c-jun-n-terminal-kinase-phosphorylation-levels-in-the-mouse-spinal-cord
#5
Suzan Gonçalves Rosa, César Augusto Brüning, Ana Paula Pesarico, Ana Cristina Guerra de Souza, Cristina Wayne Nogueira
Appropriate treatment of pain requires analgesics and anti-inflammatory drugs generally associated with undesirable side effects and not fully effective in a significant proportion of patients. Organoselenium compounds elicit a plenty of pharmacological effects in different animal models. Among these compounds, the 2,2`-dipyridyl diselenide (DPD) has a potent antioxidant effect and low toxicity. In this way, the aim of this study was to investigate the possible DPD antinociceptive effect and its mechanism of action, as well as the safety of the compound...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29773068/pharmacokinetic-and-pharmacodynamic-relationship-of-blinatumomab-in-patients-with-non-hodgkin-lymphoma
#6
Youssef Hijazi, Matthias Klinger, Andrea Kratzer, Benjamin Wu, Patrick A Baeuerle, Peter Kufer, Andreas Wolf, Dirk Nagorsen, Min Zhu
OBJECTIVE: We describe the relationship between pharmacokinetics (PK) of blinatumomab and pharmacodynamic (PD) changes in peripheral lymphocytes, serum cytokines, and tumor size in patients with non-Hodgkin lymphoma (NHL). METHODS: In a phase 1 study, 76 patients with relapsed/refractory NHL received blinatumomab by continuous intravenous infusion at various doses (0.5 to 90 µg/m2/day). PD changes were analyzed with respect to dose, blinatumomab concentration at steady state (Css), and cumulative area under the concentration-versus-time curve (AUCcum)...
May 17, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29761950/-optimization-of-the-pseudorandom-input-signals-used-for-the-forced-oscillation-technique
#7
Xiaoli Liu, Nan Zhang, Hong Liang, Zhengbo Zhang, Deyu Li, Weidong Wang
The forced oscillation technique (FOT) is an active pulmonary function measurement technique that was applied to identify the mechanical properties of the respiratory system using external excitation signals. FOT commonly includes single frequency sine, pseudorandom and periodic impulse excitation signals. Aiming at preventing the time-domain amplitude overshoot that might exist in the acquisition of combined multi sinusoidal pseudorandom signals, this paper studied the phase optimization of pseudorandom signals...
October 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29751116/pharmacokinetics-of-high-dose-propylene-glycol-free-melphalan-in-multiple-myeloma-patients-undergoing-autologous-hematopoietic-cell-transplantation
#8
Binod Dhakal, Anita D'Souza, Arjun Lakshman, Mehdi Hamadani, Saurabh Chhabra, Robert Thompson, Nirav Shah, Marcelo Pasquini, Paramweswaran Hari
High dose melphalan followed by autologous stem cell transplant (ASCT) is standard of care for eligible patients with multiple myeloma (MM). EVOMELAR (propylene glycol-free melphalan HCl, PG-Free Mel) was approved by the FDA as conditioning therapy for ASCT in MM in two daily 100 mg/m2 doses for a total dose of 200 mg/m2 . In this phase II, open-label study; PG-Free Mel (EvomelaR ) conditioning was given at single dose of 200 mg/m2 on day -2 pre-ASCT in order to establish pharmacokinetic (PK) parameters and safety...
May 8, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29745649/a-dynamic-model-of-resource-allocation-in-response-to-the-presence-of-a-synthetic-construct
#9
Axel Nyström, Antonis Papachristodoulou, Andrew Angel
Introducing synthetic constructs into bacteria often carries a burden that leads to reduced fitness and selective pressure for organisms to mutate their constructs and hence to a reduced functional lifetime. Understanding burden requires suitable methods for accurate measurement and quantification. We develop a dynamic growth model from physiologically relevant first-principles that allows parameters relevant to burden to be extracted from standard growth curves. We test several possibilities for the response of a bacterium to a new environment in terms of resource allocation...
May 10, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29744553/changes-in-mirna-5196-expression-as-a-potential-biomarker-of-anti-tnf-%C3%AE-therapy-in-rheumatoid-arthritis-and-ankylosing-spondylitis-patients
#10
Marzena Ciechomska, Krzysztof Bonek, Michal Merdas, Patryk Zarecki, Jerzy Swierkot, Piotr Gluszko, Katarzyna Bogunia-Kubik, Wlodzimierz Maslinski
In this study, we analysed the expression level of sera circulating miRNA-5196 in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients before and after tumor necrosis factor (TNF)-α therapy as biomarkers predicting positive treatment outcome. We enrolled 10 RA patients, 13 AS patients, and 12 healthy individuals in the study. The expression of miRNA-5196 was measured by real-time polymerase chain reaction before and after anti-TNF-α therapy. Disease activity of RA patients was assessed using disease activity score 28 (DAS28), whereas ankylosing spondylitis DAS (ASDAS) was used in AS patients...
May 9, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29743813/plasma-asprosin-concentrations-are-increased-in-individuals-with-glucose-dysregulation-and-correlated-with-insulin-resistance-and-first-phase-insulin-secretion
#11
Yuren Wang, Hua Qu, Xin Xiong, Yuyang Qiu, Yong Liao, Yingchun Chen, Yi Zheng, Hongting Zheng
Background: Adipokines are reported to participate in many common pathologic processes of glucose dysregulation, such as insulin resistance, β -cell dysfunction, and chronic inflammation. Objective: To detect the concentrations of plasma asprosin in subjects with impaired glucose regulation (IGR) and newly diagnosed type 2 diabetes (nT2DM) and its relationship to parameters of glucose and lipid metabolism, insulin resistance, and pancreatic β -cell function. Methods: 143 eligible participants were included and were divided into three groups including normal glucose regulation (NGR, n = 52), IGR ( n = 40), and nT2DM group ( n = 51)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29741773/phase-2-trial-of-neoadjuvant-chemotherapy-and-transoral-endoscopic-surgery-with-risk-adapted-adjuvant-therapy-for-squamous-cell-carcinoma-of-the-head-and-neck
#12
Jared M Weiss, Juneko E Grilley-Olson, Allison Mary Deal, Jose P Zevallos, Bhishamjit S Chera, Jennifer Paul, Mary Fleming Knowles, Dmitriy Usenko, Mark C Weissler, Samip Patel, David N Hayes, Trevor Hackman
BACKGROUND: The objective of this study was to demonstrate the feasibility and efficacy of induction chemotherapy, surgery, and pathology-guided adjuvant therapy to treat transorally resectable squamous head and neck cancer. METHODS: Patients had squamous head and neck cancer that was resectable by the transoral route and advanced-stage disease (American Joint Committee on Cancer stage III-IV, T3-T4 tumors, and/or positive lymph nodes). They received treatment with weekly carboplatin at an area under the curve of 2, plus paclitaxel 135 mg/m2 , and daily lapatinib 1000mg for 6 weeks followed by surgical resection...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29736847/changes-in-sensorimotor-related-thalamic-diffusion-properties-and-cerebrospinal-fluid-hydrodynamics-predict-gait-responses-to-tap-test-in-idiopathic-normal-pressure-hydrocephalus
#13
Ping-Huei Tsai, Yung-Chieh Chen, Shih-Wei Chiang, Teng-Yi Huang, Ming-Chung Chou, Hua-Shan Liu, Hsiao-Wen Chung, Giia-Sheun Peng, Hsin-I Ma, Hung-Wen Kao, Cheng-Yu Chen
OBJECTIVES: To compare diffusion tensor (DT)-derived indices from the thalamic nuclei and cerebrospinal fluid (CSF) hydrodynamic parameters for the prediction of gait responsiveness to the CSF tap test in early iNPH patients. METHODS: In this study, 22 patients with iNPH and 16 normal controls were enrolled with the approval of an institutional review board. DT imaging and phase-contrast magnetic resonance imaging were performed in patients and controls to determine DT-related indices of the sensorimotor-related thalamic nuclei and CSF hydrodynamics...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29736597/differential-mobility-spectrometry-mass-spectrometry-dms-ms-in-radiation-biodosimetry-rapid-and-high-throughput-quantitation-of-multiple-radiation-biomarkers-in-nonhuman-primate-urine
#14
Zhidan Chen, Stephen L Coy, Evan L Pannkuk, Evagelia C Laiakis, Albert J Fornace, Paul Vouros
High-throughput methods to assess radiation exposure are a priority due to concerns that include nuclear power accidents, the spread of nuclear weapon capability, and the risk of terrorist attacks. Metabolomics, the assessment of small molecules in an easily accessible sample, is the most recent method to be applied for the identification of biomarkers of the biological radiation response with a useful dose-response profile. Profiling for biomarker identification is frequently done using an LC-MS platform which has limited throughput due to the time-consuming nature of chromatography...
May 7, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29733524/safety-and-pharmacokinetics-of-veliparib-extended-release-in-patients-with-advanced-solid-tumors-a-phase-i-study
#15
Theresa L Werner, Jasgit Sachdev, Elizabeth M Swisher, Martin Gutierrez, Muaiad Kittaneh, Mark N Stein, Hao Xiong, Martin Dunbar, Danielle Sullivan, Philip Komarnitsky, Mark McKee, Antoinette R Tan
The poly(ADP-ribose) polymerase-1/2 inhibitor veliparib is active against tumors deficient in homologous DNA damage repair. The pharmacokinetics and safety of veliparib extended-release (ER) were evaluated in patients with advanced solid tumors. This phase I study assessed veliparib-ER up to 800 mg once daily or 600 mg twice daily. Dose-limiting toxicities (DLTs), recommended phase II dose (RP2D), and maximum tolerated dose (MTD) were assessed in cycle 1 and safety/tolerability during continuous administration (28-day cycles)...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29722834/effects-of-caloric-and-noncaloric-sweeteners-on-antroduodenal-motility-gastrointestinal-hormone-secretion-and-appetite-related-sensations-in-healthy-subjects
#16
Anne Christin Meyer-Gerspach, Jessica R Biesiekierski, Eveline Deloose, Egbert Clevers, Alessandra Rotondo, Jens F Rehfeld, Inge Depoortere, Lukas Van Oudenhove, Jan Tack
Background: Activation of gastrointestinal (GI) sweet taste receptors by caloric sweeteners triggers secretion of anorexigenic and inhibition of orexigenic GI hormones to regulate food intake. The effect of noncaloric sweeteners on these mechanisms is controversial. We have recently shown that motilin-induced gastric phase III contractions signal hunger feelings, thereby identifying GI motility, and its regulatory hormone motilin, as novel players in food intake regulation. Objective: The objective of the present study was to determine the effect of caloric and noncaloric sweeteners on GI motility, GI hormone secretion, and hunger in humans...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29709447/a-phase-iii-randomised-trial-of-the-immunogenicity-and-safety-of-quadrivalent-versus-trivalent-inactivated-subunit-influenza-vaccine-in-adult-and-elderly-subjects-assessing-both-anti-haemagglutinin-and-virus-neutralisation-antibody-responses
#17
Serge van de Witte, Jos Nauta, Emanuele Montomoli, Jos Weckx
BACKGROUND: Trivalent influenza vaccines (TIVs) offer substantial protection against matching B-strains, however, protection against alternate-lineage B-strains may be enhanced by adding a second B-strain in quadrivalent influenza vaccines (QIVs). In this Phase III, double-blind, multicentre, randomised study, the immunogenicity and safety of subunit inactivated QIV versus TIV was assessed in adult (aged ≥18 to ≤60 years) and elderly (aged ≥61 years) subjects by analysing a combination of haemagglutinin inhibition (HI) and virus neutralisation (VN)...
April 27, 2018: Vaccine
https://www.readbyqxmd.com/read/29708633/utility-of-the-immature-granulocyte-percentage-for-diagnosing-acute-appendicitis-among-clinically-suspected-appendicitis-in-adult
#18
Jae-Sang Park, June-Sung Kim, Youn-Jung Kim, Won Young Kim
BACKGROUND: Acute appendicitis is the most common cause of abdominal surgical emergencies that present at the emergency department (ED). Although early phase of acute appendicitis cannot induce systemic inflammatory responses, it may induce proliferation immature granulocyte before leukocytosis is occurred. Based on this, we hypothesized that IG% may be beneficial for detecting appendicitis, in addition to classic inflammatory markers including the WBC count, a left shift in neutrophils, and CRP, at no additional cost...
April 30, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29706937/aerobic-growth-of-rhodococcus-aetherivorans-bcp1-using-selected-naphthenic-acids-as-the-sole-carbon-and-energy-sources
#19
Alessandro Presentato, Martina Cappelletti, Anna Sansone, Carla Ferreri, Elena Piacenza, Marc A Demeter, Silvia Crognale, Maurizio Petruccioli, Giorgio Milazzo, Stefano Fedi, Alexander Steinbüchel, Raymond J Turner, Davide Zannoni
Naphthenic acids (NAs) are an important group of toxic organic compounds naturally occurring in hydrocarbon deposits. This work shows that Rhodococcus aetherivorans BCP1 cells not only utilize a mixture of eight different NAs (8XNAs) for growth but they are also capable of marked degradation of two model NAs, cyclohexanecarboxylic acid (CHCA) and cyclopentanecarboxylic acid (CPCA) when supplied at concentrations from 50 to 500 mgL-1 . The growth curves of BCP1 on 8XNAs, CHCA, and CPCA showed an initial lag phase not present in growth on glucose, which presumably was related to the toxic effects of NAs on the cell membrane permeability...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29703432/antiviral-activity-safety-and-tolerability-of-multiple-ascending-doses-of-elbasvir-or-grazoprevir-in-participants-infected-with-hepatitis-c-virus-genotype-1-or-3
#20
Wendy W Yeh, Iain P Fraser, Patricia Jumes, Amelia Petry, Inge De Lepeleire, Martine Robberechts, Christina Reitmann, Kristien Van Dyck, Xiaobi Huang, Zifang Guo, Deborah Panebianco, Robert B Nachbar, Edward O'Mara, John A Wagner, Joan R Butterton, Frank J Dutko, Valentin Moiseev, Zhanna Kobalava, Andreas Hüser, Sorin Visan, Christian Schwabe, Edward Gane, Serghei Popa, Nelea Ghicavii, Markus Uhle, Frank Wagner
PURPOSE: Elbasvir (MK-8742) and grazoprevir (MK-5172; Merck & Co, Inc, Kenilworth, New Jersey) are hepatitis C virus (HCV)-specific inhibitors of the nonstructural protein 5A phosphoprotein and the nonstructural protein 3/4A protease, respectively. The aims of these studies were to evaluate the antiviral activity and safety of different doses of elbasvir or grazoprevir each administered as monotherapy to participants infected with either HCV genotype (GT) 1 or GT3. METHODS: These 2 double-blind, randomized, placebo-controlled, sequential-panel, multiple ascending dose studies were conducted to assess the safety and pharmacodynamics of 5 days of once-daily elbasvir or 7 days of once-daily grazoprevir in adult male participants chronically infected with either HCV GT1 or GT3...
April 24, 2018: Clinical Therapeutics
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