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https://www.readbyqxmd.com/read/29136653/drlumi-an-open-source-package-to-manage-data-calibrate-and-conduct-quality-control-of-multiplex-bead-based-immunoassays-data-analysis
#1
Hector Sanz, John J Aponte, Jaroslaw Harezlak, Yan Dong, Aintzane Ayestaran, Augusto Nhabomba, Maxmillian Mpina, Obiang Régis Maurin, Núria Díez-Padrisa, Ruth Aguilar, Gemma Moncunill, Agnandij Selidji Todagbe, Claudia Daubenberger, Carlota Dobaño, Clarissa Valim
Multiplex bead-based immunoassays are used to measure concentrations of several analytes simultaneously. These assays include control standard curves (SC) to reduce between-plate variability and normalize quantitation of analytes of biological samples. Suboptimal calibration might result in large random error and decreased number of samples with analyte concentrations within the limits of quantification. Suboptimal calibration may be a consequence of poor fitness of the functions used for the SC, the treatment of the background noise and the method used to estimate the limits of quantification...
2017: PloS One
https://www.readbyqxmd.com/read/29134775/changes-in-sensitivity-to-the-effects-of-atrazine-on-the-luteinizing-hormone-surge-in-female-sprague-dawley-rats-after-repeated-daily-doses-correlation-with-liver-enzyme-expression
#2
Charles B Breckenridge, Chad D Foradori, Pragati Sawhney Coder, James W Simpkins, Robert L Sielken, Robert J Handa
BACKGROUND: Atrazine suppression of the LH surge slowly develops over time and peaks after 4 days; sensitivity to atrazine decreases after 8 or 14 days of dosing. Adaptation of the LH response was correlated with increased phase I and phase II liver enzyme activity/expression. METHODS: The effect of atrazine on the LH surge was evaluated in female Sprague-Dawley rats administered 100 mg/kg/day atrazine by gavage for 1, 2, 3, or 4 consecutive days or 6.5, 50, or 100 mg/kg/day atrazine for 4, 8, or 14 days...
November 14, 2017: Birth defects research
https://www.readbyqxmd.com/read/29131533/a-phase-i-ii-pharmacokinetics-pharmacodynamics-study-of-irinotecan-combined-with-s-1-for-recurrent-metastatic-breast-cancer-in-patients-with-selected-ugt1a1-genotypes-the-jbcrg-m01-study
#3
Hiroshi Ishiguro, Shigehira Saji, Shogo Nomura, Sunao Tanaka, Takayuki Ueno, Masahide Onoue, Hiroji Iwata, Takeharu Yamanaka, Yasutsuna Sasaki, Masakazu Toi
S-1 and irinotecan combination is attractive for breast cancer refractory to anthracyclines and taxanes. Patients with advanced human epidermal growth factor receptor 2 (HER2)-negative breast cancer previously treated with anthracyclines and taxanes were eligible. Patients with brain metastases and homozygous for UGT1A1 *6 or *28 or compound heterozygous (*6/*28) were excluded. A dose-escalation design was chosen for the phase I portion (level 1: irinotecan 80 mg/m(2)  days 1-8 and S-1 80 mg/m(2)  days 1-14 every 3 weeks; level 2: irinotecan 100 mg/m(2) and S-1 80 mg/m(2) )...
November 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29106303/dynamics-of-core-body-temperature-cycles-in-long-term-measurements-under-real-life-conditions-in-women
#4
D Ekhart, H Wicht, T Kersken, H Ackermann, M Kaczmarczyk, G Pretzsch, H Alexander, H W Korf
Studies under real life conditions become more and more relevant in chronobiological and chronomedical research. The present study aims to analyze one of the most prominent biological rhythms: the core body temperature (CBT) rhythm in the real world outside the laboratory. CBT was recorded continuously in 37 healthy women (age between 21 and 44 years, median 29 years) with a newly developed intravaginal temperature sensor for up to 102 days. Sleep logs were available from 23 participants. To quantify the daily dynamics of each individual CBT-curve, novel measurement parameters are introduced which permit the quantification of the phase and shape of the CBT rhythms as well as their relation to the sleep-wake cycle...
November 6, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29105802/circulating-micrornas-and-treatment-response-in-the-phase-ii-swog-s0925-study-for-patients-with-new-metastatic-hormone-sensitive-prostate-cancer
#5
Heather H Cheng, Melissa Plets, Hongli Li, Celestia S Higano, Catherine M Tangen, Neeraj Agarwal, Nicholas J Vogelzang, Maha Hussain, Ian M Thompson, Muneesh Tewari, Evan Y Yu
BACKGROUND: Previous studies suggest circulating, blood-based microRNAs (miRNAs) may serve as minimally invasive prostate cancer biomarkers, however there is limited data from prospective clinical trials. Here, we explore the role of candidate plasma miRNAs as potential biomarkers in the SWOG 0925 randomized phase II study of androgen deprivation combined with cixutumumab versus androgen deprivation alone in patients with new metastatic hormone-sensitive prostate cancer. METHODS: Correlative biospecimens, including circulating tumor cells (CTCs) and plasma for miRNA analysis, were collected at baseline and after 12 weeks on treatment from 50 patients enrolled on SWOG 0925...
November 6, 2017: Prostate
https://www.readbyqxmd.com/read/29095072/relationship-between-radioadaptive-response-and-individual-radiosensitivity-to-low-doses-of-gamma-radiation-an-extended-study-of-chromosome-damage-in-blood-lymphocytes-of-three-donors
#6
Olga Komova, Eugene Krasavin, Elena Nasonova, Larisa Mel'nikova, Nina Shmakova, Micaela Cunha, Etienne Testa, Michaël Beuve
PURPOSE: Our study aimed at evaluating: 1) whether well established variability in radioadaptive response (AR) in various donor blood lymphocytes might be attributed to inter-individual differences in radiosensitivity to different low dose levels; 2) whether AR is reproducibly present over time in the lymphocytes of AR-positive individuals. Experimental procedure: Whole blood samples of 3 donors were exposed to low doses (2-30 cGy) of γ-radiation alone (G0 phase) or followed by a 1 Gy challenge dose (late S/early G2 phase), and chromosome aberration were scored to assess the dose-response relationship and adaptive response, correspondingly...
November 2, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29067316/active-a%C3%AE-immunotherapy-cad106-in-alzheimer-s-disease-a-phase-2b-study
#7
Rik Vandenberghe, Marie-Emmanuelle Riviere, Angelika Caputo, Judit Sovago, R Paul Maguire, Martin Farlow, Giovanni Marotta, Raquel Sanchez-Valle, Philip Scheltens, J Michael Ryan, Ana Graf
INTRODUCTION: This randomized, double-blind, placebo-controlled, 90-week study assessed safety, tolerability, and immunogenicity of CAD106 with/without adjuvant in patients with mild Alzheimer's disease. METHODS: One hundred twenty-one patients received up to seven intramuscular injections of CAD106 (150 μg or 450 μg) or placebo ± adjuvant over 60 weeks. An amyloid positron emission tomography (PET) substudy was also conducted. RESULTS: CAD106 induced strong serological responses (amyloid-beta [Aβ]-Immunoglobuline G[IgG]) in 55...
January 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29064750/the-attenuation-distribution-across-the-long-axis-of-breast-cancer-liver-metastases-at-ct-a-quantitative-biomarker-for-predicting-overall-survival
#8
Richard G Abramson, Nikita Lakomkin, Allison Hainline, Hakmook Kang, M Shane Hutson, Carlos L Arteaga
OBJECTIVE: The objective of our study was to compare attenuation distribution across the long-axis (ADLA) measurements, Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, and Choi criteria for predicting overall survival (OS) in patients with metastatic breast cancer treated with bevacizumab. MATERIALS AND METHODS: We obtained HIPAA-compliant data from a prospective, multisite, phase 3 trial of bevacizumab for the treatment of metastatic breast cancer...
October 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29061746/a-new-water-dispersible-paediatric-formulation-of-dihydroartemisinin-piperaquine-for-the-treatment-of-uncomplicated-plasmodium-falciparum-malaria-in-african-infants-efficacy-and-tolerability-outcomes-of-a-phase-ii-randomized-open-label-multicenter-study
#9
Nicola Gargano, Lola Madrid, Giovanni Valentini, Umberto D'Alessandro, Tinto Halidou, Sodiomon Sirima, Antoinette Tshefu, Ali Mtoro, Samwel Gesase, Quique Bassat
Artemisinin combination therapies are considered the mainstay of malaria treatment, but paediatric friendly formulations for the treatments of infants are scarce. We aimed to evaluate the efficacy and safety of a new dispersible tablet formulation of dihydroartemisinin/piperaquine phosphate (DHA/PQP) in comparison to the marketed tablet (Eurartesim®) in the treatment of infants with uncomplicated P. falciparum malaria.Reported here are the results of a large phase II, randomized, open label, multicenter trial conducted in African infants (6-12 months of age) from Mozambique, Burkina Faso, The Gambia, DR-Congo and Tanzania...
October 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29061199/sulfur-fertilization-increases-defense-metabolites-and-nitrogen-but-decreases-plant-resistance-against-a-host-specific-insect
#10
N A Santos, N C Teixeira, J O S Valim, E F A Almeida, M G A Oliveira, W G Campos
We tested the sulfur-modulated plant resistance hypothesis using potted cabbage (Brassica oleracea var. capitata) plants that were grown without and with increasing levels of sulfur fertilization. Changes in plant chemical traits were assessed and developmental performance of Plutella xylostella, a highly host-specific leaf-chewing insect, was followed. Leaf sulfur concentration gradually increased with growing addition of sulfur in soil; however, there was a generalized saturation response curve, with a plateau phase, for improvements in total leaf nitrogen, defense glucosinolates and insect performance...
October 24, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/29059544/neural-oscillatory-mechanisms-during-novel-grammar-learning-underlying-language-analytical-abilities
#11
Olga Kepinska, Ernesto Pereda, Johanneke Caspers, Niels O Schiller
The goal of the present study was to investigate the initial phases of novel grammar learning on a neural level, concentrating on mechanisms responsible for individual variability between learners. Two groups of participants, one with high and one with average language analytical abilities, performed an Artificial Grammar Learning (AGL) task consisting of learning and test phases. During the task, EEG signals from 32 cap-mounted electrodes were recorded and epochs corresponding to the learning phases were analysed...
October 20, 2017: Brain and Language
https://www.readbyqxmd.com/read/29051507/a-new-description-of-epileptic-seizures-based-on-dynamic-analysis-of-a-thalamocortical-model
#12
H Sohanian Haghighi, A H D Markazi
Increasing evidence suggests that the brain dynamics can be interpreted from the viewpoint of nonlinear dynamical systems. The aim of this paper is to investigate the behavior of a thalamocortical model from this perspective. The model includes both cortical and sensory inputs that can affect the dynamic nature of the model. Driving response of the model subjected to various harmonic stimulations is considered to identify the effects of stimulus parameters on the cortical output. Detailed numerical studies including phase portraits, Poincare maps and bifurcation diagrams reveal a wide range of complex dynamics including period doubling and chaos in the output...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29049632/an-engineering-model-to-test-for-sensory-reweighting-in-non-human-primate-posture
#13
Lara A Thompson, Csilla Haburcakova, Adam D Goodworth, Richard F Lewis
Quantitative animal models are critically needed to provide proof-of-concept for the investigation of rehabilitative balance therapies (e.g., invasive vestibular prostheses) and treatment response prior to, or in conjunction with, human clinical trials. This paper describes a novel approach to modeling the non-human primate postural control system. Our observation that rhesus macaques and humans have even remotely similar postural control motivates the further application of the rhesus macaque as a model for studying the effects of vestibular dysfunction, as well as vestibular prosthesis-assisted states, on human postural control...
October 10, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29044458/patient-reported-quality-of-life-outcomes-after-de-escalated-chemoradiation-for-human-papillomavirus-positive-oropharyngeal-carcinoma-findings-from-a-phase-2-trial
#14
John V Hegde, Narek Shaverdian, Megan E Daly, Carol Felix, Deborah L Wong, Michael H Rosove, Jordan H Garst, Pin-Chieh Wang, Darlene Veruttipong, Shyam Rao, Ruben C Fragoso, Jonathan W Riess, Michael L Steinberg, Allen M Chen
BACKGROUND: The current study represents a subset analysis of quality-of-life (QOL) outcomes among patients treated on a phase 2 trial of de-escalated chemoradiation for human papillomavirus (HPV)-associated oropharyngeal cancer. METHODS: Eligibility included newly diagnosed, (American Joint Committee on Cancer, 7th edition) stage III or IV oropharyngeal squamous cell carcinoma, p16 positivity, age ≥ 18 years, and a Zubrod performance status of 0 to 1. Treatment was induction paclitaxel at a dose of 175 mg/m(2) and carboplatin at an area under the curve of 6 for 2 cycles followed by response-adapted, dose-reduced radiation of 54 Gy or 60 Gy with weekly concurrent paclitaxel at a dose of 30 mg/m(2) ...
October 17, 2017: Cancer
https://www.readbyqxmd.com/read/29040682/dose-response-curves-for-analyzing-of-dicentric-chromosomes-and-chromosome-translocations-following-doses-of-1000-mgy-or-less-based-on-irradiated-peripheral-blood-samples-from-five-healthy-individuals
#15
Y Abe, Mitsuaki A Yoshida, Kurumi Fujioka, Yumiko Kurosu, Risa Ujiie, Aki Yanagi, Naohiro Tsuyama, Tomisato Miura, Toshiya Inaba, Kenji Kamiya, Akira Sakai
In terms of biological dosimetry at the time of radiation exposure, the dicentric chromosome (Dic) assay (DCA) is the gold standard for assessing for the acute phase and chromosome translocation (Tr) analysis is the gold standard for assessing the chronic phase. It is desirable to have individual dose-response curves (DRCs) for each laboratory because the analysis criteria differ between laboratories. We constructed the DRCs for radiation dose estimation (with three methods) using peripheral blood (PB) samples from five healthy individuals...
October 13, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29037107/first-in-man-evaluation-of-124-i-pgn650-a-pet-tracer-for-detecting-phosphatidylserine-as-a-biomarker-of-the-solid-tumor-microenvironment
#16
Richard Laforest, Farrokh Dehdashti, Yongjian Liu, Jennifer Frye, Sarah Frye, Hannah Luehmann, Deborah Sultan, Joseph S Shan, Bruce D Freimark, Barry A Siegel
PURPOSE: PGN650 is a F(ab')2 antibody fragment that targets phosphatidylserine (PS), a marker normally absent that becomes exposed on tumor cells and tumor vasculature in response to oxidative stress and increases in response to therapy. PGN650 was labeled with (124)I to create a positron emission tomography (PET) agent as an in vivo biomarker for tumor microenvironment and response to therapy. In this phase 0 study, we evaluated the pharmacokinetics, safety, radiation dosimetry, and tumor targeting of this tracer in a cohort of patients with cancer...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/29031770/effects-of-three-major-amino-acids-found-in-japanese-broth-on-glucose-metabolism-and-gastric-emptying
#17
Fumika Mano, Kaori Ikeda, Erina Joo, Shunsuke Yamane, Norio Harada, Nobuya Inagaki
OBJECTIVES: To our knowledge, the effect of the broth of dried kelp and dried bonito, dashi, on glucose metabolism and digestion has rarely been studied. Based on the component analysis of three actual broths served in traditional restaurants, a chemically synthesized broth with three free amino acids (histidine, glutamate, aspartate) and salt was prepared to investigate their effect on glucose metabolism, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide 1 (GLP-1) secretion, and digestion...
August 10, 2017: Nutrition
https://www.readbyqxmd.com/read/29027028/determination-of-avidity-of-igg-against-protein-antigens-from-streptococcus-pneumoniae-assay-development-and-preliminary-application-in-clinical-settings
#18
D C Andrade, I C Borges, N Ekström, T Jartti, T Puhakka, A Barral, H Kayhty, O Ruuskanen, C M Nascimento-Carvalho
The measurement of antibody levels is a common test for the diagnosis of Streptococcus pneumoniae infection in research. However, the quality of antibody response, reflected by avidity, has not been adequately evaluated. We aimed to evaluate the role of avidity of IgG against eight pneumococcal proteins in etiologic diagnosis. Eight pneumococcal proteins (Ply, CbpA, PspA1 and 2, PcpA, PhtD, StkP-C, and PcsB-N) were used to develop a multiplex bead-based avidity immunoassay. The assay was tested for effects of the chaotropic agent, multiplexing, and repeatability...
October 12, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29022084/exposure-response-analyses-of-trastuzumab-emtansine-in-patients-with-her2-positive-advanced-breast-cancer-previously-treated-with-trastuzumab-and-a-taxane
#19
Chunze Li, Bei Wang, Shang-Chiung Chen, Russell Wada, Dan Lu, Xin Wang, Daniel Polhamus, Jonathan French, Shweta Vadhavkar, Alexander Strasak, Melanie Smitt, Amita Joshi, Meghna Samant, Angelica Quartino, Jin Jin, Sandhya Girish
PURPOSE: In the phase III EMILIA study, trastuzumab emtansine (T-DM1) significantly improved progression-free survival (PFS) and overall survival (OS) versus capecitabine plus lapatinib (control) in previously treated human epidermal growth factor receptor 2-positive advanced breast cancer. Using EMILIA data, we evaluated the T-DM1 exposure-response relationship. METHODS: Exposure-response relationships were examined with four exposure metrics [model-predicted and observed minimum concentration (C min) and area under the concentration-time curve from time zero to day 21 of T-DM1 at cycle 1] and multiple efficacy (OS, PFS, objective response rate) and safety (grade ≥ 3 adverse events, grade ≥ 3 thrombocytopenia, grade ≥ 3 hepatotoxicity) endpoints...
October 11, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28988992/limb-leaf-designs-for-adaptive-exploration-of-the-dose-response-curve
#20
John Spivack, Bin Cheng, Bruce Levin
We propose a two-stage strategy, called the Limb-Leaf method, to explore the dose-response curve using dose promotion and addition in the context of adaptive seamless Phase II/III trials. Strong control of the overall type 1 familywise error rate of the proposed method is enforced by the closed testing principle. The design constants are determined to minimize the risk-adjusted expected total sample size while maintaining a target power. In the case of a nonmonotonic dose response curve where more doses are required to adequately explore the curve, substantial savings in sample size are achieved compared with a traditional strategy which offers only selection and promotion from among initial first stage doses...
October 6, 2017: Contemporary Clinical Trials
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