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treatment of hypertension

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https://www.readbyqxmd.com/read/29908131/low-body-mass-index-is-a-risk-factor-for-hyperkalaemia-associated-with-angiotensin-converting-enzyme-inhibitors-and-angiotensin-ii-receptor-blockers-treatments
#1
T Hirai, R Yamaga, A Fujita, T Itoh
WHAT IS KNOWN AND OBJECTIVE: Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) represent the cornerstones of hypertension and congestive heart failure treatment. Risk factors for hyperkalaemia associated with ACEI and ARB are chronic kidney disease and concomitant medications which increase serum potassium level. Body mass index (BMI) also affects pharmacokinetics of ACEI and ARB and potassium disposition. We evaluated the relationship between BMI and hyperkalaemia associated with ACEI and ARB treatments...
June 16, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29907885/recognition-and-control-of-hypertension-diabetes-and-dyslipidemia-in-patients-with-rheumatoid-arthritis
#2
Luísa Lima Castro, Cristina Costa Duarte Lanna, Mariana Pimenta Rocha, Antônio Luiz Pinho Ribeiro, Rosa Weiss Telles
Absolute cardiovascular risk of an individual with rheumatoid arthritis (RA) is greater when compared to the general population, and several factors have proven to be important for the development of coronary artery disease (CAD) in these patients, including factors related to the underlying disease, such as the systemic inflammatory response, drugs used in its treatment, and a higher prevalence of traditional risk factors for CAD. Our aim is to describe the recognition and control frequencies of systemic arterial hypertension (SAH), dyslipidemia, and diabetes mellitus (DM) in RA patients...
June 15, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29907135/doxorubicin-induced-cardiotoxicity-is-suppressed-by-estrous-staged-treatment-and-exogenous-17%C3%AE-estradiol-in-female-tumor-bearing-spontaneously-hypertensive-rats
#3
Kaytee L Pokrzywinski, Thomas G Biel, Elliot T Rosen, Julia L Bonanno, Baikuntha Aryal, Francesca Mascia, Delaram Moshkelani, Steven Mog, V Ashutosh Rao
BACKGROUND: Doxorubicin (DOX), an anthracycline therapeutic, is widely used to treat a variety of cancer types and known to induce cardiomyopathy in a time and dose-dependent manner. Postmenopausal and hypertensive females are two high-risk groups for developing adverse effects following DOX treatment. This may suggest that endogenous reproductive hormones can in part suppress DOX-induced cardiotoxicity. Here, we investigated if the endogenous fluctuations in 17β-estradiol (E2) and progesterone (P4) can in part suppress DOX-induced cardiomyopathy in SST-2 tumor-bearing spontaneously hypersensitive rats (SHRs) and evaluate if exogenous administration of E2 and P4 can suppress DOX-induced cardiotoxicity in tumor-bearing ovariectomized SHRs (ovaSHRs)...
June 15, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29906708/biochemical-derangements-related-to-metabolic-syndrome-in-epileptic-patients-on-treatment-with-valproic-acid
#4
Yadav Nisha, Zachariah Bobby, Vaibhav Wadwekar
PURPOSE: Evaluation of biochemical derangements related to metabolic syndrome in epileptic patients on treatment with Valproic acid. METHODS: This study consisted of two groups of 42 patients. Group I - Newly diagnosed patients with epileptic seizures untreated with any Anti-epileptic drugs (AEDs). Group II - Patients on treatment with Valproic acid for more than one year. Age and gender matched patients of 18-40 years were recruited. Patients who were diabetic, hypertensive, smokers, alcoholics, with persistent infection, head injuries, pregnancy and lactation were excluded from the study...
June 5, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29906429/death-or-debt-national-estimates-of-financial-toxicity-in-persons-with-newly-diagnosed-cancer
#5
Adrienne M Gilligan, David S Alberts, Denise J Roe, Grant H Skrepnek
PURPOSE: To evaluate the impact of cancer upon a patient's depletion of net worth and incursion of debt in the U.S. METHODS: This longitudinal study used the Health and Retirement Study (HRS) from 1998-2014. Persons ≥50 years with newly-diagnosed malignancies were included, excluding minor skin cancers. Multivariable generalized linear models were employed to assess changes in net worth and debt (consumer, mortgage, home equity) at two-and four-years following diagnosis (Year+2 , Year+4 ) after controlling for demographic and clinically-related variables, cancer-specific attributes, economic factors, and mortality...
June 12, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29906243/the-chemerin-knockout-rat-reveals-chemerin-dependence-in-female-but-not-male-experimental-hypertension
#6
Stephanie W Watts, Emma S Darios, Adam E Mullick, Hannah Garver, Thomas L Saunders, Elizabeth D Hughes, Wanda E Filipiak, Michael G Zeidler, Nichole McMullen, Christopher J Sinal, Ramya K Kumar, David J Ferland, Gregory D Fink
Measures of the adipokine chemerin are elevated in multiple cardiovascular diseases, including hypertension, but little mechanistic work has been done to implicate chemerin as being causative in such diseases. The chemerin knockout (KO) rat was created to test the hypothesis that removal of chemerin would reduce pressure in the normal and hypertensive state. Western analyses confirmed loss of chemerin in the plasma and tissues of the KO vs. wild-type (WT) rats. Chemerin concentration in plasma and tissues was lower in WT females than in WT males, as determined by Western analysis...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29906223/new-mouse-model-of-pulmonary-hypertension-induced-by-respiratory-syncytial-virus-bronchiolitis
#7
Dai Kimura, Jordy Saravia, Sridhar Jaligama, Isabella McNamara, Luan D Vu, Ryan D Sullivan, Salvatore Mancarella, Dahui You, Stephania A Cormier
Pulmonary hypertension (PH) has been observed in up to 75% of infants with moderate to severe respiratory syncytial virus (RSV) bronchiolitis and is associated with significant morbidity and mortality in infants with congenital heart disease. The purpose of this study was to establish a mouse model of PH secondary to RSV bronchiolitis that mimics the disease etiology as it occurs in infants. Neonatal mice were infected with RSV at 5 days of age, and then re-infected 4 weeks later. Serum free medium was administered to age-matched mice as control...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29905927/multicenter-randomized-double-blind-phase-2-trial-of-folfiri-with-regorafenib-or-placebo-as-second-line-therapy-for-metastatic-colorectal-cancer
#8
Hanna K Sanoff, Richard M Goldberg, Anastasia Ivanova, Seamus O'Reilly, Samer S Kasbari, Richard D Kim, Ray McDermott, Dominic T Moore, William Zamboni, William Grogan, Allen Lee Cohn, Tanios S Bekaii-Saab, Gregory Leonard, Theresa Ryan, Olugbenga O Olowokure, Nishan H Fernando, John McCaffrey, Bassel F El-Rayes, Anne M Horgan, Gary Bradley Sherrill, George Hosni Yacoub, Bert H O'Neil
BACKGROUND: Regorafenib, a multikinase inhibitor that inhibits angiogenesis, growth, and proliferation, prolongs survival as monotherapy in patients with refractory colorectal cancer. This international, double-blind, placebo-controlled, multicenter trial assessed the efficacy of regorafenib with folinic acid, fluorouracil, and irinotecan (FOLFIRI) as a second-line treatment for metastatic colorectal cancer. METHODS: Patients with metastatic colorectal cancer who progressed on first-line oxaliplatin and fluoropyrimidine enrolled at 45 sites in the United States and Ireland...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29905926/resistant-hypertension
#9
Fang-Fei Wei, Zhen-Yu Zhang, Qi-Fang Huang, Wen-Yi Yang, Jan A Staessen
The publication of the first non-randomised proof-of-concept trial of renal denervation as a treatment modality in treatment-resistant hypertension set the stage for a search for novel devices with the expectation that technology would reduce the burden of hypertension by reducing or eliminating the costly and lifelong use of blood pressure lowering medications. As we demonstrate in this review, this idea so attractive to manufacturers and invasive cardiologists and radiologists overlooked decades of careful pathophysiological research in a disease, which still remains enigmatic but remains the major cause of cardiovascular mortality worldwide...
June 15, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29905883/hypertonic-saline-or-mannitol-for-treating-elevated-intracranial-pressure-in-traumatic-brain-injury-a-meta-analysis-of-randomized-controlled-trials
#10
Jiajie Gu, Haoping Huang, Yuejun Huang, Haitao Sun, Hongwu Xu
Hyperosmolar therapy is regarded as the mainstay for treatment of elevated intracranial pressure (ICP) in traumatic brain injury (TBI). This still has been disputed as application of hypertonic saline (HS) or mannitol for treating patients with severe TBI. Thus, this meta-analysis was performed to further compare the advantages and disadvantages of mannitol with HS for treating elevated ICP after TBI. We conducted a systematic search on PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Wan Fang Data, VIP Data, SinoMed, and China National Knowledge Infrastructure (CNKI) databases...
June 15, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29905774/j-curves-in-hypertension-what-do-they-tell-us-about-treatment-of-high-blood-pressure
#11
Johann Auer, James E Sharman, Thomas Weber
No abstract text is available yet for this article.
June 13, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29905556/association-between-components-of-metabolic-syndrome-and-cognitive-dysfunction-cross-sectional-study-among-the-population-of-the-turkestan-region
#12
K Madenbay, Zh Shalkharova, Zh Shalkharova, G Nuskabayeva, K Sadykova
Metabolic syndrome (MetS) being a risk factor for many vascular pathologic processes is associated with cognitive dysfunction with vascular genesis. Objective - to study the relationship between clinical and metabolic indicators and the presence of cognitive dysfunction in persons with MetS. A transverse study was conducted in the Turkestan region of Southern Kazakhstan during which a general clinical, laboratory examination and evaluation of cognitive function was performed in 639 patients. To assess the relationship between the MetS, its individual components and cognitive function with Mini Mental State Examination test (MMSE) multinominal logistic regression analysis was used...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905555/goodpascher-s-syndrome-the-challenges-in-a-timely-diagnosis-and-treatment-in-medical-practice-clinical-case
#13
V Talash, T Bevzenko, T Yarmola, L Tkachenko, H Pustovoyt
The article presents a clinical case with intravital diagnosis of Goodpascher's syndrome in a 22 years old patient. In this work we analyze clinical, laboratory-instrumental, pathologoanatomic and pathomorphological aspects of the disease, which was accompanied by glomerulonephritis with rapidly progressive renal insufficiency, anemia, arterial hypertension and symptoms of lung injury. Article emphasizes on the necessity of timely diagnosis of Goodpascher's syndrome and following administration of immunosuppressive therapy...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904903/nurse-s-contribution-to-alleviate-non-adherence-to-hypertension-treatment
#14
REVIEW
G Georgiopoulos, Z Kollia, V Katsi, D Oikonomou, C Tsioufis, D Tousoulis
PURPOSE OF REVIEW: Hypertension consists a major risk factor for cardiovascular events. Despite the proven effectiveness of antihypertensive treatment, approximately half of hypertensive patients have inadequate blood pressure control. Non-adherence to medication has been shown to be an important barrier to achieving adequate blood pressure control and nurse interventions can substantially improve therapeutic compliance. We sought to evaluate the role of nurse interventions in alleviating non-adherence to medication in patients with hypertension by performing a systematic review of the literature for all relevant articles...
June 15, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29904831/pain-in-optic-neuropathies
#15
Stefania Bianchi Marzoli, Alessandra Criscuoli
Pain occurs with optic neuropathies associated with inflammatory central nervous system diseases (MS and NMO), idiopathic intracranial hypertension and spontaneous hypotension, giant cell arteritis, immunomediated systemic diseases, compressive lesions, or infective disorders. Pain can precede the onset of visual loss in acute optic neuritis, it can be irradiated to the orbital region in giant cell arteritis and parasellar compressive optic neuropathies, or it may be located to the back of the eye with posterior scleritis...
June 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29904721/surveillance-for-portal-hypertension-in-the-course-of-liver-cirrhosis
#16
REVIEW
Anna Piekarska, Ewa K Berkan, Kamila M Wójcik
Non-invasive liver fibrosis assessment techniques are under development for evaluating the severity of liver disease and portal hypertension. The paper presents practical arrangements for the diagnosis and treatment of portal hypertension in patients with chronic liver disease, established in the Baveno VI Consensus Workshop for diagnosis and treatment of portal hypertension. Currently, the diagnostic standard of liver disease severity is transient elastography, which can identify patients with clinically significant portal hypertension (liver stiffness > 20 kPa)...
June 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29904577/surgical-treatment-of-obesity
#17
REVIEW
Vance L Albaugh, Naji N Abumrad
Obesity prevalence continues to increase worldwide, as do the numerous chronic diseases associated with obesity, including diabetes, non-alcoholic fatty liver disease, dyslipidemia, and hypertension. The prevalence of bariatric surgery also continues to increase and remains the most effective and sustainable treatment for obesity. Over the last several years, numerous prospective and longitudinal studies have demonstrated the benefits of bariatric surgery on weight loss, mortality, and other chronic diseases...
2018: F1000Research
https://www.readbyqxmd.com/read/29904497/segmental-arterial-mediolysis-presenting-as-spontaneous-bilateral-renal-artery-dissection
#18
Nirmal K Onteddu, Zakaria Hindi, Gaurav Rajashekar, Sanjeeva P Kalva
The commonest site of primary dissection involving the visceral vessels is renal arteries; however, spontaneous bilateral renal artery dissection is an extremely rare entity. Spontaneous renal artery dissection (SRAD) is rarely a cause of renovascular hypertension. Segmental arterial mediolysis is a rare arteriopathy of unknown etiology which is a nonatherosclerotic and noninflammatory condition. We report a case of a 51-year-old male patient with spontaneous dissection of bilateral renal arteries with clinical, laboratory, and angiographic findings consistent with segmental artery mediolysis...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29904482/variceal-bleeding-in-the-small-intestine-successfully-treated-with-balloon-occluded-retrograde-transvenous-obliteration-using-n-butyl-2-cyanoacrylate-a-case-report
#19
Koichi Masuda, Shinsuke Takenaga, Hirokazu Ashida, Hiroya Ojiri
Rupture of small intestinal varices associated with portal hypertension can be a serious condition that is difficult to diagnose early and to manage. Moreover, optimal guidelines for the treatment of small intestinal varices have not yet been established. We herein report a case of a 73-year-old man with small intestinal varices. The man presented with bleeding from a stoma in the small intestine, which subsequently led to hemorrhagic shock. We successfully treated the patient with balloon-occluded retrograde transvenous obliteration via the right inferior epigastric vein using N-butyl-2-cyanoacrylate...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29904472/bleeding-stomal-varices-in-portal-hypertension
#20
Karen Tran-Harding, Michael Winkler, Driss Raissi
We report a case of a 50-year-old man with a history of liver cirrhosis and colon cancer post end colostomy presenting to the emergency department with stomal bleeding and passage of clots into the colostomy bag. The patient was treated with transjugular intrahepatic portosystemic shunt (TIPS) and concomitant embolization of the stomal varices via the TIPS shunt using N-butyl cyanoacrylate mixed with ethiodol. Although stomal variceal bleeding is uncommon, this entity can have up to 40% mortality upon initial presentation, given the challenges in diagnosis and management...
April 2018: Radiology Case Reports
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