keyword
MENU ▼
Read by QxMD icon Read
search

triptolide

keyword
https://www.readbyqxmd.com/read/29676120/-preparation-and-transdermal-permeation-of-triptolide-and-ferulic-acid-ethosomes-gel-in-vitro
#1
Ling Tao, Liang-Fei He, Yong-Mei Guan, Li-Hua Chen, Wei-Feng Zhu, Chen Jin, Lu Wu
The aim of this study was to prepare triptolide and ferulic acid ethosomes gel, investigate its transdermal permeation, and compare the results with ordinary gel and cream. Improved Franz diffusion cell method was used in the transdermal delivery experiment with rat abdominal skin as in vitro model. The receptor fluid at different time points was collected; ferulic acid concentration was determined by high performance liquid chromatography (HPLC) and triptolide concentration was determined by liquid chromatography-electrospray ionization mass spectrometry (LC-MS/MS)...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29670349/fabrication-of-a-triptolide-loaded-and-poly-%C3%AE-glutamic-acid-based-amphiphilic-nanoparticle-for-the-treatment-of-rheumatoid-arthritis
#2
Li Zhang, Junli Chang, Yongjian Zhao, Hao Xu, Tengteng Wang, Qiang Li, Lianping Xing, Jing Huang, Yongjun Wang, Qianqian Liang
Triptolide (TP) exhibits immunosuppressive, cartilage-protective and anti-inflammatory effects in rheumatoid arthritis. However, the toxicity of TP limits its widespread use. To decrease the toxic effects, we developed a novel nano-drug carrier system containing TP using poly-γ-glutamic acid-grafted di-tert-butyl L-aspartate hydrochloride (PAT). PAT had an average diameter of 79±18 nm, a narrow polydispersity index (0.18), a strong zeta potential (-32 mV) and a high drug encapsulation efficiency (EE1 =48...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29665897/-effects-of-triptolide-combined-with-homoharringtonine-on-proliferation-and-apoptosis-of-kg-1%C3%AE-cells
#3
Xin Li, Jia-Yan Liu, Xiao-Hong Yuan, Zhen-Xing Lin, Yong Wu
OBJECTIVE: To investigate the effect and possible mechanism of low concentration of triptolide (TPL) combined with homoharringtonine (HHT) on the proliferation and apoptosis of KG-1α cells. METHODS: CCK-8 method was used to detect the antiproliferating effects of different concentrations of TPL and HHT single-use and combined use on KG-1α cells, and the combined index (CI) was calculated. The colony formation ability was also determined by methylcellulose colony formation assay, cell surface molecules, apoptosis rate and cell cycle changes were detected by flow cytometry...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29649522/triptolide-up-regulates-metabotropic-glutamate-receptor-5-to-inhibit-microglia-activation-in-the-lipopolysaccharide-induced-model-of-parkinson-s-disease
#4
Yi-Ying Huang, Qian Zhang, Jian-Nan Zhang, Ya-Nan Zhang, Li Gu, Hui-Min Yang, Ning Xia, Xiao-Min Wang, Hong Zhang
Metabotropic glutamate receptor (mGlu)5 regulates microglia activation, which contributes to inflammation. However, the role of mGlu5 in neuroinflammation associated with Parkinson's disease (PD) remains unclear. Triptolide (T10) exerts potent immunosuppressive and anti-inflammatory effects and protects neurons by inhibiting microglia activation. In this study, we investigated the role of mGlu5 in the anti-inflammatory effect of T10 in a lipopolysaccharide (LPS)-induced PD model. In cultured BV2 cells and primary microglia, blocking mGlu5 activity or knocking down its expression abolished T10-inhibited release of proinflammatory cytokines induced by LPS...
April 9, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29618945/inducers-of-senescence-toxic-compounds-and-senolytics-the-multiple-faces-of-nrf2-activating-phytochemicals-in-cancer-adjuvant-therapy
#5
REVIEW
Marco Malavolta, Massimo Bracci, Lory Santarelli, Md Abu Sayeed, Elisa Pierpaoli, Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Maurizio Cardelli, Mauro Provinciali
The reactivation of senescence in cancer and the subsequent clearance of senescent cells are suggested as therapeutic intervention in the eradication of cancer. Several natural compounds that activate Nrf2 (nuclear factor erythroid-derived 2-related factor 2) pathway, which is involved in complex cytoprotective responses, have been paradoxically shown to induce cell death or senescence in cancer. Promoting the cytoprotective Nrf2 pathway may be desirable for chemoprevention, but it might be detrimental in later stages and advanced cancers...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29615906/mechanisms-of-triptolide-induced-hepatotoxicity-and-protective-effect-of-combined-use-of-isoliquiritigenin-possible-roles-of-nrf2-and-hepatic-transporters
#6
Zhenyan Hou, Lei Chen, Pingfei Fang, Hualin Cai, Huaibo Tang, Yongbo Peng, Yang Deng, Lingjuan Cao, Huande Li, Bikui Zhang, Miao Yan
Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated. This study aims to explore the role of nuclear transcription factor E2-related factor 2 (Nrf2) and hepatic transporters in TP-induced hepatotoxicity and the reversal protective effect of ISL. TP treatment caused both cytotoxicity in L02 hepatocytes and acute liver injury in mice...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29606369/various-signaling-pathways-in-multiple-myeloma-cells-and-effects-of-treatment-on-these-pathways
#7
REVIEW
Ali Dehghanifard, Saeid Kaviani, Saeid Abroun, Mahshad Mehdizadeh, Sajedeh Saiedi, Amirhosein Maali, Sasan Ghaffari, Mehdi Azad
Multiple myeloma (MM) results from malignancy in plasma cells and occurs at ages > 50 years. MM is the second most common hematologic malignancy after non-Hodgkin lymphoma, which constitutes 1% of all malignancies. Despite the great advances in the discovery of useful drugs for this disease such as dexamethasone and bortezomib, it is still an incurable malignancy owing to the development of drug resistance. The tumor cells develop resistance to apoptosis, resulting in greater cell survival, and, ultimately, develop drug resistance by changing the various signaling pathways involved in cell proliferation, survival, differentiation, and apoptosis...
March 17, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29576708/further-study-of-influence-of-panax-notoginseng-on-intestinal-absorption-characteristics-of-triptolide-and-tripterine-in-rats-with-tripterygium-wilfordii
#8
Yiqun Li, Benyong Zhang, Mengzhu Liu, Xinlong Zhang, Donglei Shi, Liwei Guo, Jinao Duan, Xueping Zhou, Huaxu Zhu, Qichun Zhang
Background: Tripterygium wilfordii (TW) is widely employed to treat rheumatoid arthritis and autoimmune disorders clinically, which, however, accompany with disturbing hepatotoxicity and nephrotoxicity. The previous research showed that Panax notoginseng (PN) compatibly and significantly reduces the TW-induced hepatotoxicity. Objective: To explore the underlying mechanism, the present study was designed to reveal the influence of PN on the intestinal absorption process of TW-derived active components in rat...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29552824/-low-dose-of-triptolide-ameliorates-podocyte-epithelial-mesenchymal-transition-induced-by-high-dose-of-d-glucose-via-inhibiting-wnt3%C3%AE-%C3%AE-catenin-signaling-pathway-activation
#9
Ge Shi, Wei Wu, Yi-Gang Wan, He Wei-Ming Hex, Yue Tu, Wen-Bei Han, Bu-Hui Liu, Ying-Lu Liu, Zi-Yue Wan
To explore the effects and molecular mechanisms of triptolide(TP)on improving podocyte epithelial-mesenchymal transition(EMT)induced by high dose of D-glucose(HG), the immortalized podocytes of mice in vitro were divided into the normal group(N), the high dose of D-glucose group(HG), the low dose of TP group(L-TP), the high dose of TP group(H-TP)and the mannitol group(MNT), and treated by the different measures respectively. More specifically, the podocytes in each group were separately treated by D-glucose(DG, 5 mmol·L⁻¹)or HG(25 mmol·L⁻¹)or HG(25 mmol·L⁻¹)+ TP(3 μg·L⁻¹)or HG(25 mmol·L⁻¹)+ TP(10 μg·L⁻¹)or DG(5 mmol·L⁻¹)+ MNT(24...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29545863/triptolide-induces-autophagy-and-apoptosis-through-erk-activation-in-human-breast-cancer-mcf-7-cells
#10
Huan Gao, Yue Zhang, Lei Dong, Xiao-Yu Qu, Li-Na Tao, Yue-Ming Zhang, Jing-Hui Zhai, Yan-Qing Song
To investigate the effects of triptolide (TPI) on proliferation, autophagy and death in human breast cancer MCF-7 cells, and to elucidate the associated molecular mechanisms, intracellular alterations were analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assays. The results of the MTT assay revealed that TPI significantly reduced the MCF-7 cell survival rate when the concentration was >10 nmol/l. TPI activated a caspase cascade reaction by regulating Bcl-2-associated X protein (Bax), caspase-3 and B-cell lymphoma 2 expression, and promoted programmed cell death via the mitochondrial pathway...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29523159/c-myc-dependent-repression-of-two-oncogenic-mirna-clusters-contributes-to-triptolide-induced-cell-death-in-hepatocellular-carcinoma-cells
#11
Shu-Guang Li, Qian-Wei Shi, Ling-Yan Yuan, Li-Ping Qin, Yan Wang, Yu-Qing Miao, Zhe Chen, Chang-Quan Ling, Wen-Xing Qin
BACKGROUND: Triptolide is a structurally unique diterpene triepoxide with potent antitumor activity. However,the effect and mechanism of triptolide on hepatocellular carcinoma (HCC) is not well studied. METHODS: Cells were treated with triptolide, and the anti-HCC activity of triptolide was evaluated using flow cytometry, western blot, and xenograft studies. MicroRNA microarray and quantitative reverse-transcription polymerase chain reaction was used to identify differential microRNAs induced by triptolide...
March 9, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29516693/-involvement-of-pi-3-k-akt-mtor-signaling-in-protective-effects-of-moxibustion-for-premature-ovarian-failure-in-rats
#12
Cai-Rong Zhang, Ji-Li Deng, Wei-Na Zhu, Ming-Xing Miao, Wei-Wei Shen, Sheng-Jun Cao, Yong Tang
OBJECTIVE: To study the protective effect of moxibustion for tripterygium-induced premature ovarian failure (POF) and its underlying mechanisms in rats. METHODS: Forty-five female SD rats were randomly divided into normal control, POF model and moxibustion groups ( n =15/group). The POF model was induced by intragastric administration of Triptolide (40 mg/kg), once daily for 6 weeks. From the 4th week after modeling, moxibustion was given at "Guanyuan" (CV 4) and bilateral "Sanyinjiao" (SP 6) for 10 min, once daily for 3 weeks...
February 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29513074/triptolide-delays-disease-progression-in-an-adult-rat-model-of-polycystic-kidney-disease-through-the-jak2-stat3-pathway
#13
Ying Jing, Ming Wu, Di Zhang, Dongping Chen, Ming Yang, Shuqin Mei, Liangliang He, Junhui Gu, Na Qi, Lili Fu, Lin Li, Changlin Mei
OBJECTIVES: The aim of our current study was to investigate the long-term effect and the mechanism of triptolide in an adult non-orthologous rat model of polycystic kidney disease (PKD), and study the effect of triptolide on the mitogenic JAK2/STAT3 pathway.. METHODS: Male wild type (WT+/+) and Cy/+ cystic Han:SPRD rats were treated with vehicle or triptolide from week 44 weeks to week 16 weeks of age. Rats were sacrificed at 16 weeks of age 16 for the blood, urine and organ collection...
March 7, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29512681/triptolide-reduces-ischemia-reperfusion-injury-in-rats-and-h9c2-cells-via-inhibition-of-nf%C3%A2-%C3%AE%C2%BAb-ros-and-the-erk1-2-pathway
#14
Bin Yang, Ping Yan, Guang-Zhao Yang, Hui-Li Cao, Fei Wang, Bao Li
Myocardial ischemia/reperfusion (I/R) induces cardiac cell injury; however, the mechanism underlying cardiac damage remains unclear. A previous study demonstrated that triptolide (TP) exerts protective effects against I/R in cerebral cells. The present study aimed to evaluate the protective effects of TP on cardiac cells, and investigated the potential mechanisms involved in I/R‑induced damage. Rats and cardiac H9C2 cells undergoing I/R were pretreated with TP, and cell damage was assessed in vivo and in vitro...
March 6, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29512444/pharmacokinetic-and-toxicological-characteristics-of-tripterigium-glycosides-and-their-derivatives
#15
Xi Du, Makafui Nyagblordzro, Lijun An, Xue Gao, Lemei Du, Yangyang Wang, Gregory Ondieki, Siambi Kikete, Xin He
Tripterigium wilfordii glycosides (TWG) demonstrate paramount bioactive effectiveness in the management of many autoimmune diseases, such as rheumatoid arthritis, psoriasis, and nephrotic syndrome. However, its side effects on the hepatic, nephrotic, reproductive, and cardiovascular systems have limited its immense therapeutic potentials. Triptolide (TP) and Celastrol (CL), the leading bioactive as well as toxic constituents of TWG, have been widely studied. These studies have documented the key mechanisms that trigger the toxic reactions and the precautionary measures that could prevent and reduce such reactions...
March 2, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29502367/-triptolide-reverses-apatinib-resistance-in-gastric-cancer-cell-line-mkn45-via-inhibition-of-heat-shock-protein-70
#16
F Teng, Z Y Xu, H Lyu, Y P Wang, L J Wang, T Huang, J C Sun, H T Zhu, Y X Ni, X D Cheng
Objective: To investigate the effect of triptolide, a specific inhibitor of heat shock protein 70 (HSP70), on apatinib resistance in gastric cancer cells line MKN45. Methods: The apatinib-resistant cells (MKN45/AR) and MKN45 parental cells were treated with apatinib, triptolide and apatinib combined with triptolide, respectively. CCK-8 assay was performed to determine the half maximal inhibitory concentration (IC(50)) of MKN45/AR and MKN45 cells in the presence of different treatment. The mRNA expression of heat shock protein gene (HSPA1A and HSPA1B) was detected by RT-PCR, while the protein expression of heat shock protein 70 was analyzed using Western blot in MKN45/AR and MKN45 cells...
February 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29500880/triptolide-sensitizes-breast-cancer-cells-to-doxorubicin-through-the-dna-damage-response-inhibition
#17
Yu Deng, Fulun Li, Pinglin He, Yafei Yang, Jin Yang, Yamei Zhang, Junying Liu, Yongping Tong, Qingfeng Li, Xian Mei, Zengyi Shu, Qi Zhao
Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune-related diseases over centuries. Recently, it was reported that a variety of cancer cell lines could be sensitized to DNA-damage based chemotherapy drugs in combination with Triptolide treatment. In the present study, we show that a short time exposure (3 hours) to Triptolide,which did not trigger apoptosis, could specifically increase breast cancer cells sensitivity to Doxorubicin rather than other chemotherapy drugs including Paclitaxel, Fluorouracil, and Mitomycin ...
March 3, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29491837/a-mechanistic-overview-of-triptolide-and-celastrol-natural-products-from-tripterygium-wilfordii-hook-f
#18
REVIEW
Shao-Ru Chen, Yan Dai, Jing Zhao, Ligen Lin, Yitao Wang, Ying Wang
Triptolide and celastrol are predominantly active natural products isolated from the medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastrol also provide neuroprotection and prevent cardiovascular and metabolic diseases. However, toxicity restricts the further development of triptolide and celastrol. In this review, we comprehensively review therapeutic targets and mechanisms of action, and translational study of triptolide and celastrol...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29483777/antitumor-effect-of-triptolide-in-t-cell-lymphoblastic-lymphoma-by-inhibiting-cell-viability-invasion-and-epithelial-mesenchymal-transition-via-regulating-the-pi3k-akt-mtor-pathway
#19
Yan Huang, Sun Wu, Yuan Zhang, Lihua Wang, Yan Guo
Introduction: T-cell lymphoblastic lymphoma (T-LBL) is a widely disseminated disease worldwide. Triptolide (TPL) is purified from Chinese herb and displays anti-inflammatory, anti-fertility, anti-tumor and immunosuppressive effects. Materials and methods: Here, in vitro and in vivo experiments were conducted to investigate the anti-tumor effect of TPL treatment in T-LBL and the potential mechanism in T-LBL progression. Results: TPL inhibited cell proliferation of T-LBL cells (Jurkat cells and Molt-3 cells) in a dose-dependent manner...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29446727/natural-terpenoids-against-female-breast-cancer-a-5-year-recent-research
#20
Sylvin Benjamin Ateba, Sadrine Tchoukouegno Ngeu, Marie Alfrede Mvondo, Job Tchoumtchoua, Charline Florence Awounfack, Liselotte Krenn, Dieudonne Njamen
BACKGROUND: The approval of Taxol® in 1993 marked the great entrance of terpenoids in the anti-cancer area and this drug is still highly important in the treatment of refractory ovarian, breast and other cancers. Over decades, other prominent natural terpenoids have become indispensable for the modern pharmacotherapy of breast cancer. However, given the rapid evolution of drug resistance, effective treatments for advanced breast cancers requiring cytotoxic chemotherapy represent a major unmet clinical need...
February 13, 2018: Current Medicinal Chemistry
keyword
keyword
54085
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"