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https://www.readbyqxmd.com/read/28816393/sperm-donation-perinatal-outcomes-in-an-australian-population-cohort
#1
Damian Adams, Renae Fernandez, Vivienne Moore, Kristyn Willson, Alice Rumbold, Sheryl de Lacey, Wendy Scheil, Michael Davies
AIM: To compare perinatal outcomes for neonates conceived with donated sperm with those for neonates conceived spontaneously in an Australian population cohort. METHODS: Perinatal outcomes for all births in South Australia for the period January 1986-December 2002 were linked with assisted reproductive treatment records to determine those conceived from donated sperm. Birth outcome measures were analyzed using Student's t-test and logistic regression using generalized estimating equations to determine statistical significance...
August 17, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28815662/risks-of-adverse-perinatal-outcomes-after-repeat-terminations-of-pregnancy-by-their-methods-a-nationwide-register-based-cohort-study-in-finland-1996-2013
#2
S Kc, M Gissler, S M Virtanen, R Klemetti
BACKGROUND: Repeat terminations of pregnancy (TOPs) are associated with an increased risk of adverse outcomes in the subsequent birth. The perinatal outcomes after repeat TOPs by their methods have not yet been properly studied. This study aimed to examine perinatal outcomes in subsequent pregnancy among the women with a singleton birth and a history of TOPs. METHODS: All the first-time mothers (n = 419 879) with a singleton birth during 1996-2013 in Finland were identified from the Medical Birth Register and linked to the Abortion Register...
August 16, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28806489/characteristics-of-spontaneous-births-attended-by-midwives-and-physicians-in-us-hospitals-in-2014
#3
Patrick Thornton
INTRODUCTION: This study compares characteristics and birth outcomes of women attended by certified nurse-midwives/certified midwives (midwives) and physicians in US hospitals in 2014. METHODS: Data reported in 2014 on the 2003 version of the US birth certificate were examined. Spontaneous vaginal births attributed to midwives and physicians and occurring in hospitals were included. Demographic and risk profiles and adjusted odds ratios for maternal and newborn outcomes were compared by provider type...
August 14, 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28806195/antiretroviral-combination-use-during-pregnancy-and-the-risk-of-major-congenital-malformations
#4
Anick Bérard, Odile Sheehy, Jin-Ping Zhao, Michal Abrahamowicz, Mona Loutfy, Isabelle Boucoiran, Sasha Bernatsky
OBJECTIVE: To quantify the risk of major congenital malformations associated with gestational combination antiretroviral use. DESIGN: Population-based prospective cohort study. METHODS: Using the Quebec Pregnancy Cohort from 1998-2015, we included women who covered by Quebec Drug Plan and have a singleton livebirth. All antiretroviral use alone or in combination were considered. Major congenital malformations overall and organ-specific malformations in the first year of life were identified...
August 12, 2017: AIDS
https://www.readbyqxmd.com/read/28805618/prenatal-diagnosis-and-molecular-cytogenetic-characterization-of-mosaicism-for-a-small-supernumerary-marker-chromosome-derived-from-chromosome-21q11-2-q21-1-and-a-literature-review
#5
Chih-Ping Chen, Ming Chen, Chia-Hsun Wu, Chen-Ju Lin, Schu-Rern Chern, Peih-Shan Wu, Yen-Ni Chen, Shin-Wen Chen, Shun-Ping Chang, Li-Feng Chen, Wayseen Wang
OBJECTIVE: We present prenatal diagnosis and molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome (sSMC) derived from chromosome 21q11.2-q21.1, and we review the literature of an sSMC(21) with a duplication of 21q11.2-q21.1. CASE REPORT: A 40-year-old woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 47,XX,+mar [18]/46,XX [4]. The parental karyotypes were normal...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28805616/prenatal-diagnosis-and-molecular-cytogenetic-characterization-of-mosaicism-for-a-small-supernumerary-marker-chromosome-derived-from-chromosome-16
#6
Chih-Ping Chen, Tsang-Ming Ko, Schu-Rern Chern, Peih-Shan Wu, Shin-Wen Chen, Shih-Ting Lai, Chien-Wen Yang, Chen-Wen Pan, Wayseen Wang
OBJECTIVE: We present prenatal diagnosis and molecular cytogenetic characterization of a small supernumerary marker chromosome (sSMC) derived from chromosome 16. CASE REPORT: A 28-year-old woman underwent amniocentesis at 17 weeks of gestation because of abnormal maternal serum screening for Down syndrome. Amniocentesis revealed a karyotype of 47,XY,+mar[5]/46,XY[9]. Parental karyotypes were normal. Prenatal ultrasound findings were unremarkable. Array comparative genomic hybridization (aCGH) analysis of cultured amniocytes revealed a de novo 16% gene dosage increase of 16q11...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28805612/detection-of-paternal-uniparental-disomy-9-in-a-neonate-with-prenatally-detected-mosaicism-for-a-small-supernumerary-marker-chromosome-9-and-a-supernumerary-ring-chromosome-9
#7
Chih-Ping Chen, Ming Chen, Liang-Kai Wang, Schu-Rern Chern, Peih-Shan Wu, Shin-Wen Chen, Shih-Ting Lai, Shun-Ping Chang, Chien-Wen Yang, Chen-Wen Pan, Wayseen Wang
OBJECTIVE: We present the association of paternal uniparental disomy (UPD) 9 with mosaicism for a small supernumerary marker chromosome 9 [sSMC(9)] and a supernumerary ring chromosome 9 [r(9)]. MATERIALS AND METHODS: A 38-year-old woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 47,XY,+mar [25]/48,XY,+mar,+r(9) [4]/47,XY,+r(9) [1]/46,XY [6]. The parental karyotypes were normal. Array comparative genomic hybridization (aCGH) of cultured amniocytes revealed a result of de novo 9p13...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28805602/laparoendoscopic-single-site-myomectomy-using-conventional-laparoscopic-instruments-and-glove-port-technique-four-years-experience-in-109-cases
#8
Szu-Yu Chen, Bor-Ching Sheu, Su-Cheng Huang, Wen-Chun Chang
OBJECTIVE: To report a single surgeon's experience with 109 laparoendoscopic single-site myomectomy (LESS-M) using conventional laparoscopic instruments and a homemade glove port system. MATERIALS AND METHODS: A total of 109 consecutive women who underwent LESS-M between March 2011 and April 2015 were reviewed. RESULTS: The mean age and body mass index were 38.3 ± 6.5 years and 22.1 ± 3.0 kg/m(2). The mean diameter of the largest myoma and the mean number of myomas were 8...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28804964/birth-outcomes-of-children-fathered-by-men-treated-with-systemic-corticosteroids-during-the-conception-period-a-cohort-study-based-on-nationwide-data
#9
M D Larsen, S Friedman, B Magnussen, B M Nørgård
Information on the safety of paternal use of medications prior to the time of conception is limited, and there is little available evidence regarding possible adverse effects of paternal use of systemic corticosteroids (SCS). In this cohort study, based on nationwide data, we examined the association between paternal use of SCS prior to conception and adverse birth outcomes. The study includes data from all singletons born in Denmark from 1January 1997 through 2013 (N=1,013,994). Children fathered by men who redeemed a prescription of SCS within 3 months before conception (N=2,380) constituted the exposed groups...
August 14, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28803228/utility-of-routine-urine-cmv-pcr-and-total-serum-igm-testing-of-small-for-gestational-age-infants-a-single-center-review
#10
Michael M Espiritu, Sean Bailey, Elena V Wachtel, Pradeep V Mally
BACKGROUND: Due to the extremely low incidence of TORCH (toxoplasmosis, rubella, CMV, herpes simplex virus) infections, diagnostic testing of all small for gestational age (SGA) infants aimed at TORCH etiologies may incur unnecessary tests and cost. OBJECTIVE: To determine the frequency of urine CMV PCR and total IgM testing among infants with birth weight <10% and the rate of test positivity. To evaluate the frequency of alternative etiologies of SGA in tested infants...
August 14, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28801981/pregnancy-outcomes-in-mothers-of-offspring-with-inherited-bone-marrow-failure-syndromes
#11
Neelam Giri, Helen D Reed, Pamela Stratton, Sharon A Savage, Blanche P Alter
BACKGROUND: Children with inherited bone marrow failure syndromes (IBMFSs) may be symptomatic in utero, resulting in maternal and fetal problems during the pregnancy. Subsequent pregnancies by their mothers should be considered "high risk". METHODS: We retrospectively analyzed outcomes of 575 pregnancies in 165 unaffected mothers of offspring with Fanconi anemia (FA), dyskeratosis congenita (DC), Diamond-Blackfan anemia (DBA), and Shwachman-Diamond syndrome (SDS) for events noted during pregnancy, labor, and delivery...
August 12, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28801627/increased-risk-of-low-birth-weight-in-women-with-placental-malaria-associated-with-p-falciparum-var2csa-clade
#12
Jaymin C Patel, Nicholas J Hathaway, Christian M Parobek, Kyaw L Thwai, Mwayiwawo Madanitsa, Carole Khairallah, Linda Kalilani-Phiri, Victor Mwapasa, Achille Massougbodji, Nadine Fievet, Jeffery A Bailey, Feiko O Ter Kuile, Philippe Deloron, Stephanie M Engel, Steve M Taylor, Jonathan J Juliano, Nicaise Tuikue Ndam, Steven R Meshnick
Pregnancy associated malaria (PAM) causes adverse pregnancy and birth outcomes owing to Plasmodium falciparum accumulation in the placenta. Placental accumulation is mediated by P. falciparum protein VAR2CSA, a leading PAM-specific vaccine target. The extent of its antigen diversity and impact on clinical outcomes remain poorly understood. Through amplicon deep-sequencing placental malaria samples from women in Malawi and Benin, we assessed sequence diversity of VAR2CSA's ID1-DBL2x region, containing putative vaccine targets and estimated associations of specific clades with adverse birth outcomes...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800769/maternal-sleep-and-small-for-gestational-age-infants-in-the-japan-environment-and-children-s-study-a-cohort-study
#13
Seiichi Morokuma, Mototsugu Shimokawa, Kiyoko Kato, Masafumi Sanefuji, Eiji Shibata, Mayumi Tsuji, Ayako Senju, Toshihiro Kawamoto, Koichi Kusuhara
OBJECTIVES: Small for gestational age infants have an increased risk of immediate complications, short-term morbidity and mortality, and long-term neurologic and metabolic disorders in adulthood. Previous research has shown that reduced sleep duration is a risk factor for SGA birth. However, only a few studies have evaluated maternal sleep as a risk factor for SGA birth. In the present study, we investigated the relationship between the amount and quality of mothers' sleep and infants' birth weight...
August 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28798085/the-association-of-falling-insulin-requirements-with-maternal-biomarkers-and-placental-dysfunction-a-prospective-study-of-women-with-pre-existing-diabetes-in-pregnancy
#14
Suja Padmanabhan, Vincent W Lee, Mark Mclean, Neil Athayde, Valeria Lanzarone, Qemer Khoshnow, Michael J Peek, N Wah Cheung
OBJECTIVE: To investigate the association of falling insulin requirements (FIR) among women with pre-existing diabetes with adverse obstetric outcomes and maternal biomarkers longitudinally in pregnancy. RESEARCH DESIGN AND METHODS: A multicenter prospective cohort study of 158 women (41 with type 1 diabetes and 117 with type 2 diabetes) was conducted. Women with FIR of ≥15% from the peak total daily dose after 20 weeks gestation were considered case subjects (n = 32)...
August 10, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28796684/maternal-and-infant-outcomes-after-human-papillomavirus-vaccination-in-the-periconceptional-period-or-during-pregnancy
#15
Heather S Lipkind, Gabriela Vazquez-Benitez, James D Nordin, Paul A Romitti, Allison L Naleway, Nicola P Klein, Rulin C Hechter, Michael L Jackson, Simon J Hambidge, Grace M Lee, Lakshmi Sukumaran, Elyse O Kharbanda
OBJECTIVE: To evaluate whether quadrivalent human papillomavirus (HPV) vaccine administered during the periconceptional period or during pregnancy was associated with increased risks for adverse obstetric events, adverse birth outcomes, or selected major structural birth defects. METHODS: We conducted a retrospective, observational cohort study using administrative and health care data from the Vaccine Safety Datalink. Insured women 13-27 years old with singleton pregnancies and a live birth from January 1, 2007, through September 1, 2013, who received quadrivalent HPV vaccine during the periconceptional period (2 weeks before to 2 weeks after their last menstrual period), during pregnancy, or during both periods combined were compared with women who had a live birth during the same time period and received quadrivalent HPV vaccine 4-18 months before their last menstrual period...
August 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28796674/neonatal-morbidity-of-small-and-large-for-gestational-age-neonates-born-at-term-in-uncomplicated-pregnancies
#16
Suneet P Chauhan, Madeline Murguia Rice, William A Grobman, Jennifer Bailit, Uma M Reddy, Ronald J Wapner, Michael W Varner, John M Thorp, Kenneth J Leveno, Steve N Caritis, Mona Prasad, Alan T N Tita, George Saade, Yoram Sorokin, Dwight J Rouse, Jorge E Tolosa
OBJECTIVE: To compare morbidity among small-for-gestational-age (SGA; birth weight less than the 10th percentile for gestational age), appropriate-for-gestational-age (AGA; birth weight 10th to 90th percentile; reference group), and large-for-gestational-age (LGA; birth weight greater than the 90th percentile) neonates in apparently uncomplicated pregnancies at term (37 weeks of gestation or greater). METHODS: This secondary analysis, derived from an observational obstetric cohort of 115,502 deliveries, included women with apparently uncomplicated pregnancies of nonanomalous singletons who had confirmatory ultrasound dating no later than the second trimester and who delivered between 37 0/7 and 42 6/7 weeks of gestation...
August 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28794003/antenatal-early-postnatal-hypothyroidism-alters-arterial-tone-regulation-in-2-week-old-rats
#17
Svetlana I Sofronova, Dina K Gaynullina, Anastasia A Shvetsova, Anna A Borzykh, Ekaterina K Selivanova, Anna P Sharova, Andrey A Martyanov, Olga S Tarasova
The mechanisms of vascular alterations resulting from early thyroid hormones deficiency are poorly understood. We tested the hypothesis that antenatal/early postnatal hypothyroidism would alter the activity of endothelial NO-pathway and Rho-kinase pathway, which are specific for developing vasculature. Dams were treated with propylthiouracil (PTU, 7 ppm) in drinking water during gestation and 2 weeks after delivery, their progeny had normal body weight but markedly reduced blood levels of thyroid hormones (ELISA)...
August 9, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28793989/early-enteral-tube-feeding-in-optimizing-treatment-of-hyperemesis-gravidarum-the-maternal-and-offspring-outcomes-after-treatment-of-hyperemesis-by-refeeding-mother-randomized-controlled-trial
#18
Iris J Grooten, Marjette H Koot, Joris Am van der Post, Joke Mj Bais, Carrie Ris-Stalpers, Christiana Naaktgeboren, Henk A Bremer, David P van der Ham, Wieteke M Heidema, Anjoke Huisjes, Gunilla Kleiverda, Simone Kuppens, Judith Oeh van Laar, Josje Langenveld, Flip van der Made, Mariëlle G van Pampus, Dimitri Papatsonis, Marie-José Pelinck, Paula J Pernet, Leonie van Rheenen, Robbert J Rijnders, Hubertina Cj Scheepers, Tatjana E Vogelvang, Ben W Mol, Tessa J Roseboom, Rebecca C Painter
Background: Hyperemesis gravidarum (HG) leads to dehydration, poor nutritional intake, and weight loss. HG has been associated with adverse pregnancy outcomes such as low birth weight. Information about the potential effectiveness of treatments for HG is limited.Objective: We hypothesized that in women with HG, early enteral tube feeding in addition to standard care improves birth weight.Design: We performed a multicenter, open-label randomized controlled trial [Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding (MOTHER)] in 19 hospitals in the Netherlands...
August 9, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28789832/association-of-preterm-birth-and-small-for-gestational-age-with-metabolic-outcomes-in%C3%A2-children-and-adolescents-a-population-based-cohort-study-from-taiwan
#19
Yu-Ting Huang, Hsiang-Yu Lin, Chung-Hsing Wang, Bai-Horng Su, Che-Chen Lin
BACKGROUND: Previous studies have identified preterm birth and/or small for gestational age (SGA) as risk factors for features of the metabolic syndrome, including high blood pressure, insulin sensitivity and atherosclerosis, occurring later in life, with controversial results. We conducted this population-based cohort study to investigate metabolic outcomes in those with former preterm birth and/or SGA status in Taiwan. METHODS: Data were obtained from Taiwan's universal National Health Insurance Research Database...
July 25, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28783807/comparative-safety-of-antiretroviral-treatment-regimens-in-pregnancy
#20
Rebecca Zash, Denise L Jacobson, Modiegi Diseko, Gloria Mayondi, Mompati Mmalane, Max Essex, Chipo Petlo, Shahin Lockman, Joseph Makhema, Roger L Shapiro
Importance: Maternal antiretroviral treatment (ART) started before conception may increase the risk for adverse birth outcomes among women with human immunodeficiency virus (HIV) infection, but whether the risk differs by ART regimen is unknown. Objective: To compare the risk for selected birth outcomes by maternal ART regimen. Design, Setting, and Participants: This observational birth outcomes surveillance study compared all live births and stillbirths with a gestational age of at least 24 weeks in 8 geographically dispersed government hospitals throughout Botswana (approximately 45% of births nationwide)...
August 7, 2017: JAMA Pediatrics
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