Yumie Takeshita, Chiaki Nomura, Hisayoshi Murai, Yusuke Mukai, Tadayuki Hirai, Takuto Hamaoka, Shota Tokuno, Takeo Tanaka, Hisanori Goto, Yujiro Nakano, Soichiro Usui, Kenichi Nakajima, Masayuki Takamura, Toshinari Takamura
INTRODUCTION: Hyperinsulinemia and hyperglycemia are associated with exaggerated systemic sympathetic nerve activity (SNA) in patients with type 2 diabetes. Sodium-glucose cotransporter 2 (SGLT2) inhibitors lower insulin levels, whereas sulfonylureas increase insulin levels. We will test whether these two classes of antidiabetic agents have different effects on SNA. METHODS: The present study is an ongoing, 24-week, one-center (only Kanazawa University Hospital), open-label, randomized, parallel trial (jRCTs 041200035)...
January 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders