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Lamellar corneal transplant

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https://www.readbyqxmd.com/read/27907157/human-bone-derived-collagen-for-the-development-of-an-artificial-corneal-endothelial-graft-in-vivo-results-in-a-rabbit-model
#1
Natalia Vázquez, Manuel Chacón, Carlos A Rodríguez-Barrientos, Jesús Merayo-Lloves, Miguel Naveiras, Begoña Baamonde, Jose F Alfonso, Iriana Zambrano-Andazol, Ana C Riestra, Álvaro Meana
Corneal keratoplasty (penetrating or lamellar) using cadaveric human tissue, is nowadays the main treatment for corneal endotelial dysfunctions. However, there is a worldwide shortage of donor corneas available for transplantation and about 53% of the world's population have no access to corneal transplantation. Generating a complete cornea by tissue engineering is still a tough goal, but an endothelial lamellar graft might be an easier task. In this study, we developed a tissue engineered corneal endothelium by culturing human corneal endothelial cells on a human purified type I collagen membrane...
2016: PloS One
https://www.readbyqxmd.com/read/27861304/trends-in-corneal-transplantation-in-keratoconus
#2
Daniel Sarezky, Stephen E Orlin, Wei Pan, Brian L VanderBeek
PURPOSE: To determine recent trends in and sociodemographic/comorbid conditions associated with penetrating keratoplasty (PK) and lamellar keratoplasty (LK) for keratoconus (KCN). METHODS: Patients with KCN and subsequent PK and LK procedures were identified using International Classification of Diseases, 9th revision (ICD-9) and Current Procedural Terminology (CPT) billing codes. The change in surgical rates was calculated over a decade, and multivariate analysis demonstrated factors associated with undergoing surgery...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27860476/-historic-survey-of-posterior-lamellar-keratoplasty-techniques-an-overview
#3
P Studený, D Křížová, P Kuchynka
Some of the modifications of posterior lamellar keratoplasty is at the present considered by most of the corneal surgeons as method of choice in case of patients corneal endothelium damage. However, this surgical technique undergoes in the last 20 years relatively rapid development. Even in the current time, there exist side by side and are used different types and modifications of this sort of transplantation. Because of this reason, differences among individual methods are sometimes not accurately understood and the terminology may be used not exactly as well...
2016: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/27821104/publication-trends-in-corneal-transplantation-a-bibliometric-analysis
#4
Evre Pekel, Gökhan Pekel
BACKGROUND: Our aim was to demonstrate the publication trends of corneal transplantation in the last decade. METHODS: All of the keratoplasty research articles, letters, case reports, reviews and meeting abstracts published between January 2006 and December 2015 indexed on the Thomson Reuters Web of Knowledge were evaluated. A bibliometric filter was used to capture keratoplasty related publications by using the key words 'keratoplasty', 'corneal transplantation' or 'keratoprosthesis' in the 'title' selection mode...
November 8, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27820748/triple-procedure-cataract-extraction-intraocular-lens-implantation-and-corneal-graft
#5
Yoshinori Oie, Kohji Nishida
PURPOSE OF REVIEW: Corneal triple procedures consist of combined keratoplasty surgery and cataract surgery. Currently, anterior lamellar keratoplasty, endothelial keratoplasty, and conventional penetrating keratoplasty, are very often simultaneously performed with cataract surgery. The present article reviews the recent advances and current developments in corneal triple procedures. RECENT FINDINGS: Many new findings have been reported. Core vitrectomy before host trephination and retroillumination during continuous curvilinear capsulorhexis has enabled us to perform penetrating keratoplasty triple procedures more safely...
January 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27755187/macular-corneal-dystrophy-and-posterior-corneal-abnormalities
#6
Yair Rubinstein, Chen Weiner, Adi Einan-Lifshitz, Noa Chetrit, Nadav Shoshany, David Zadok, Isaac Avni, Eran Pras
PURPOSE: This study reports the presentation of 2 families with macular corneal dystrophy (MCD). The aim of this study was to show whether ultrasound biomicroscopy (UBM) can, based on posterior changes of the cornea in MCD, assist in the choice of surgery, either anterior lamellar keratoplasty (DALK) or penetrating keratoplasty (PK), compared with optical coherence tomography (OCT) and Scheimpflug. METHODS: Six patients with MCD were examined for their best-corrected visual acuity, slit-lamp, OCT, UBM, and Scheimpflug findings...
October 14, 2016: Cornea
https://www.readbyqxmd.com/read/27741016/outcomes-of-descemet-stripping-endothelial-keratoplasty-using-eye-bank-prepared-preloaded-grafts
#7
Sotiria Palioura, Kathryn Colby
PURPOSE: To evaluate the feasibility of Descemet stripping endothelial keratoplasty using grafts preloaded by an eye bank in a commercially available insertion device. METHODS: In this retrospective case series, a series of 35 eyes in 34 consecutive patients who underwent Descemet stripping endothelial keratoplasty for Fuchs endothelial dystrophy or previously failed full-thickness grafts at a single tertiary care center from March 2013 to March 2014 was included...
January 2017: Cornea
https://www.readbyqxmd.com/read/27723276/engineered-basement-membranes-for-regenerating-the-corneal-endothelium
#8
Rachelle N Palchesko, James L Funderburgh, Adam W Feinberg
Basement membranes are protein-rich extracellular matrices (ECM) that are essential for epithelial and endothelial tissue structure and function. Aging and disease cause changes in the physical properties and ECM composition of basement membranes, which has spurred research to develop methods to repair and/or regenerate these tissues. An area of critical clinical need is the cornea, where failure of the endothelium leads to stromal edema and vision loss. Here, an engineered basement membrane (EBM) is developed that consists of a dense layer of collagen IV and/or laminin ≈5-10 nm thick, created using surface-initiated assembly, conformally attached to a collagen I film...
October 10, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27688591/outcomes-of-keratoplasty-in-the-mucopolysaccharidoses-an-international-perspective
#9
Kaitlyn L Ohden, Susanne Pitz, Jane Ashworth, Augusto Magalhães, Diane R Marinho, Päivi Lindahl, Kristina Teär Fahnehjelm, C Gail Summers
OBJECTIVE: To describe visual outcomes after penetrating keratoplasty and deep anterior lamellar keratoplasty in patients with mucopolysaccharidoses. METHODS: This is a retrospective review of keratoplasty in consecutive patients from Brazil, England, Finland, Germany, Portugal, Sweden and the USA. All patients had corneal clouding due to mucopolysaccharidoses. Preoperative and postoperative visual outcome and ocular comorbidities were identified. Success was arbitrarily defined as any improvement in visual acuity or best-corrected visual acuity better than logarithm of the minimum angle of resolution 0...
September 28, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27638316/refractive-outcomes-of-penetrating-keratoplasty-and-deep-anterior-lamellar-keratoplasty-in-fellow-eyes-for-keratoconus
#10
Emilio Pedrotti, Mattia Passilongo, Adriano Fasolo, Sara Ficial, Stefano Ferrari, Giorgio Marchini
PURPOSE: To compare the refractive outcomes following penetrating keratoplasty and deep anterior lamellar keratoplasty in fellow eyes in patients with keratoconus. METHODS: This is an observational retrospective review of consecutive patients with keratoconus first managed with penetrating keratoplasty in one eye and then with lamellar keratoplasty in the fellow eye, between 2002 and 2007. Data collection was based on patients' hospital records. Information related to assessment before surgery and at 1, 3, 6, 12, 24, and 48 months after keratoplasty were retrieved and considered in the analysis...
September 15, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27635063/new-zealand-trends-in-corneal-transplantation-over-the-25%C3%A2-years-1991-2015
#11
Bia Z Kim, Jay J Meyer, Nigel H Brookes, S Louise Moffatt, Helen C Twohill, David G Pendergrast, Trevor Sherwin, Charles N J McGhee
AIMS: To report the 25-year longitudinal trends in indications and corneal transplantation techniques in New Zealand. METHODS: Statistical analysis of prospectively acquired New Zealand National Eye Bank (NZNEB) electronic database from 1991 to 2015 inclusive. Subjects were recipients of corneal transplants in 62 centres supplied by the NZNEB. Main outcome measures were indications, recipient age and transplantation techniques. RESULTS: From January 1991 to December 2015, NZNEB supplied tissue for 5574 corneal transplants, increasing annually from 89 (1991) to 290 (2015)...
September 15, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27617875/applications-of-biomaterials-in-corneal-endothelial-tissue-engineering
#12
Tsung-Jen Wang, I-Jong Wang, Fung-Rong Hu, Tai-Horng Young
When corneal endothelial cells (CECs) are diseased or injured, corneal endothelium can be surgically removed and tissue from a deceased donor can replace the original endothelium. Recent major innovations in corneal endothelial transplantation include replacement of diseased corneal endothelium with a thin lamellar posterior donor comprising a tissue-engineered endothelium carried or cultured on a thin substratum with an organized monolayer of cells. Repairing CECs is challenging because they have restricted proliferative ability in vivo...
November 2016: Cornea
https://www.readbyqxmd.com/read/27538194/intensified-early-postoperative-topical-steroids-do-not-influence-endothelial-cell-density-after-descemet-membrane-endothelial-keratoplasty-combined-with-cataract-surgery-triple-dmek
#13
Robert Hoerster, Tisha P Stanzel, Bjoern O Bachmann, Sebastian Siebelmann, Claus Cursiefen
PURPOSE: To investigate the effect of intensified postoperative topical steroid therapy after Descemet membrane endothelial keratoplasty combined with cataract surgery (Triple-DMEK) on postoperative endothelial cell density (ECD). METHODS: This comparative clinical study with historical controls was conducted at a tertiary hospital, specialized in corneal surgery. Patients undergoing DMEK or Triple-DMEK are included prospectively in the Cologne DMEK Database. Until April 2014, first week's postoperative standard therapy for lamellar keratoplasties was prednisolone acetate eye drops 1% applied 5× daily...
November 2016: Cornea
https://www.readbyqxmd.com/read/27496499/changes-in-technique-and-indications-for-keratoplasty-in-poland-1989-to-2014-an-analysis-of-corneal-transplantations-performed-at-saint-barbara-hospital-trauma-center-sosnowiec-poland
#14
J Jankowska-Szmul, D Dobrowolski, K Krysik, J Kwas, M Nejman, E Wylegala
BACKGROUND: The purpose of this work was to study the evolving trends in techniques and indications for corneal transplantation in Poland. METHODS: This retrospective, descriptive analysis of corneal transplantations was performed at the Ophthalmology Department of Saint Barbara Hospital, Trauma Center, Sosnowiec, Poland, between 1988 and 2014. Structure of indications and surgery type rates over 26 years were tabulated by means of 5-year intervals. RESULTS: Between 1989 and 2014, 1762 corneal transplantations were performed, including 1375 (78%) cases of penetrating keratoplasty, 137 (8%) lamellar keratoplasty, 112 (6%) patch grafts, and 138 (8%) keratolimbal allografts...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27491697/sequential-bilateral-corneal-transplantation-and-graft-survival
#15
Bernhard Steger, Elinor Curnow, Robert Cheeseman, Vito Romano, Abigail Kaye, Mark Jones, Stephen Kaye
PURPOSE: To investigate graft survival and rejection following sequential bilateral corneal transplantation. DESIGN: Retrospective cohort study. METHODS: The study included patients with Fuchs endothelial dystrophy (FED), pseudophakic bullous keratopathy (PBK), or keratoconus who had undergone a penetrating keratoplasty (PK), endothelial keratoplasty (EK), or deep anterior lamellar keratoplasty (DALK) between 1999 and 2012. The main cohort included patients who had received a first transplant in both eyes for the same indication and a control cohort patients who had undergone a unilateral first corneal transplant...
October 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27472438/three-dimensional-mapping-of-the-orientation-of-collagen-corneal-lamellae-in-healthy-and-keratoconic-human-corneas-using-shg-microscopy
#16
Raffaella Mercatelli, Fulvio Ratto, Francesca Rossi, Francesca Tatini, Luca Menabuoni, Alex Malandrini, Riccardo Nicoletti, Roberto Pini, Francesco Saverio Pavone, Riccardo Cicchi
Keratoconus is an eye disorder that causes the cornea to take an abnormal conical shape, thus impairing its refractive functions and causing blindness. The late diagnosis of keratoconus is among the principal reasons for corneal surgical transplantation. This pathology is characterized by a reduced corneal stiffness in the region immediately below Bowman's membrane, probably due to a different lamellar organization, as suggested by previous studies. Here, the lamellar organization in this corneal region is characterized in three dimensions by means of second-harmonic generation (SHG) microscopy...
July 29, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27413493/trends-in-indications-and-techniques-of-corneal-transplantation-in-iran-from-2006-to-2013-an-8-year-review
#17
Mozhgan Rezaei Kanavi, Mohammad Ali Javadi, Tahmineh Motevasseli, Tahereh Chamani, Mahnoush Rezaei Kanavi, Bahareh Kheiri, Sare Safi
PURPOSE: To report changing trends in indications and techniques of corneal transplantation in Iran. METHODS: We reviewed eye bank records of 47,129 patients who had undergone corneal transplantation between 2006 and 2013 at different eye centers throughout Iran. RESULTS: The most common indication for corneal transplantation was keratoconus (KCN, n = 21,350 eyes, 45.3%), followed by bullous keratopathy (BK, n = 8,566 eyes, 18.2%), corneal opacity and scar (COS, n = 7,158 eyes, 15...
April 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27330270/changing-indications-and-techniques-for-corneal-transplantations-at-a-tertiary-referral-center-in-turkey-from-1995-to-2014
#18
Yesim Altay, Ayse Burcu, Gozde Aksoy, Evin Singar Ozdemir, Firdevs Ornek
BACKGROUND: Indications for corneal transplantation in developed and developing nations differ according to the different spectrum of corneal disease in each country. OBJECTIVE: The purpose of this study is to analyze the changing indications and surgical techniques for corneal transplantation over the past 20 years at a tertiary referral center in Turkey. METHODS: We retrospectively reviewed the records of patients who underwent keratoplasty from January 1995 to December 2014 (between 1995 and 2004, period 1, and between 2005 and 2014, period 2)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27291975/ultrastructural-analysis-of-the-decellularized-cornea-after-interlamellar-keratoplasty-and-microkeratome-assisted-anterior-lamellar-keratoplasty-in-a-rabbit-model
#19
Yoshihide Hashimoto, Shinya Hattori, Shuji Sasaki, Takako Honda, Tsuyoshi Kimura, Seiichi Funamoto, Hisatoshi Kobayashi, Akio Kishida
The decellularized cornea has received considerable attention for use as an artificial cornea. The decellularized cornea is free from cellular components and other immunogens, but maintains the integrity of the extracellular matrix. However, the ultrastructure of the decellularized cornea has yet to be demonstrated in detail. We investigated the influence of high hydrostatic pressure (HHP) on the decellularization of the corneal ultrastructure and its involvement in transparency, and assessed the in vivo behaviour of the decellularized cornea using two animal transplantation models, in relation to remodelling of collagen fibrils...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27267629/transparent-resilient-human-amniotic-membrane-laminates-for-corneal-transplantation
#20
Takehiro Hariya, Yuji Tanaka, Shunji Yokokura, Toru Nakazawa
This study evaluated a new technique to toughen and optically clarify human amniotic membrane (AM) tissue, which is naturally thin and clouded, and determined the suitability of the altered tissue for corneal transplantation. The technique created a tissue laminate by repeatedly depositing wet layers of AM and dehydrating them, followed by chemical cross-linking to tighten integration at the layer interfaces and within the layers, thereby improving the physical properties of the laminates by increasing light transmittance and mechanical strength...
September 2016: Biomaterials
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