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https://www.readbyqxmd.com/read/29164483/dosimetry-based-treatment-planning-for-molecular-radiotherapy-a-summary-of-the-2017-report-from-the-internal-dosimetry-task-force
#1
Caroline Stokke, Pablo Minguez Gabiña, Pavel Solný, Francesco Cicone, Mattias Sandström, Katarina Sjögreen Gleisner, Carlo Chiesa, Emiliano Spezi, Maria Paphiti, Mark Konijnenberg, Matt Aldridge, Jill Tipping, Michael Wissmeyer, Boudewijn Brans, Klaus Bacher, Carsten Kobe, Glenn Flux
BACKGROUND: The European directive on basic safety standards (Council directive 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. The directive comes into operation February 2018, and the aim of a report produced by the Internal Dosimetry Task Force of the European Association of Nuclear Medicine is to address this aspect of the directive. A summary of the report is presented. RESULTS: A brief review of five of the most common therapy procedures is included in the current text, focused on the potential to perform patient-specific dosimetry...
November 21, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29158873/contribution-and-interactions-of-hydroxycinnamic-acids-found-in-bran-and-wholegrain-sorghum-sorghum-bicolor-l-moench-effects-on-the-antioxidant-capacity-and-inhibition-of-human-erythrocyte-hemolysis
#2
Norma Julieta Salazar-López, Gustavo A González-Aguilar, Guadalupe Loarca-Piña, Francisco J Cinco-Moroyoqui, Ofelia Rouzaud-Sández, J Abraham Domínguez-Avila, Maribel Robles-Sánchez
An imbalance between free radicals and antioxidants is known as oxidative stress, and it promotes cellular aging and the development of chronic noncommunicable diseases. The bioactive compounds present in food play an important role in preventing oxidative stress. The aim of this study was to determine the contributions and interactions of the hydroxycinnamic acids found in the bran and whole grain of sorghum and to evaluate their effects on the antioxidant capacity and inhibition of the hemolysis of human erythrocytes...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29158844/quantitative-imaging-for-targeted-radionuclide-therapy-dosimetry-technical-review
#3
REVIEW
Tiantian Li, Edwin C I Ao, Bieke Lambert, Boudewijn Brans, Stefaan Vandenberghe, Greta S P Mok
Targeted radionuclide therapy (TRT) is a promising technique for cancer therapy. However, in order to deliver the required dose to the tumor, minimize potential toxicity in normal organs, as well as monitor therapeutic effects, it is important to assess the individualized internal dosimetry based on patient-specific data. Advanced imaging techniques, especially radionuclide imaging, can be used to determine the spatial distribution of administered tracers for calculating the organ-absorbed dose. While planar scintigraphy is still the mainstream imaging method, SPECT, PET and bremsstrahlung imaging have promising properties to improve accuracy in quantification...
2017: Theranostics
https://www.readbyqxmd.com/read/29158777/combined-genome-and-transcriptome-sequencing-to-investigate-the-plant-cell-wall-degrading-enzyme-system-in-the-thermophilic-fungus-malbranchea-cinnamomea
#4
Silvia Hüttner, Thanh Thuy Nguyen, Zoraide Granchi, Thomas Chin-A-Woeng, Dag Ahrén, Johan Larsbrink, Vu Nguyen Thanh, Lisbeth Olsson
Background: Genome and transcriptome sequencing has greatly facilitated the understanding of biomass-degrading mechanisms in a number of fungal species. The information obtained enables the investigation and discovery of genes encoding proteins involved in plant cell wall degradation, which are crucial for saccharification of lignocellulosic biomass in second-generation biorefinery applications. The thermophilic fungus Malbranchea cinnamomea is an efficient producer of many industrially relevant enzymes and a detailed analysis of its genomic content will considerably enhance our understanding of its lignocellulolytic system and promote the discovery of novel proteins...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29151861/microgeographic-differentiation-in-thermal-performance-curves-between-rural-and-urban-populations-of-an-aquatic-insect
#5
Nedim Tüzün, Lin Op de Beeck, Kristien I Brans, Lizanne Janssens, Robby Stoks
The rapidly increasing rate of urbanization has a major impact on the ecology and evolution of species. While increased temperatures are a key aspect of urbanization ("urban heat islands"), we have very limited knowledge whether this generates differentiation in thermal responses between rural and urban populations. In a common garden experiment, we compared the thermal performance curves (TPCs) for growth rate and mortality in larvae of the damselfly Coenagrion puella from three urban and three rural populations...
December 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/29150515/loop-of-streptomyces-feruloyl-esterase-plays-an-important-role-in-its-activity-of-releasing-ferulic-acid-from-biomass
#6
Misugi Uraji, Haruka Tamura, Eiichi Mizohata, Jiro Arima, Kun Wan, Ken'ichi Ogawa, Tsuyoshi Inoue, Tadashi Hatanaka
Feruloyl esterases (FAEs) are key enzymes required for the production of ferulic acid from agricultural biomass. Previously, we identified and characterized R18, an FAE from Streptomyces cinnamoneus NBRC 12852, which showed no sequence similarity with the known FAEs. To determine the region involved in its catalytic activity, we constructed chimeric enzymes using R18 and its homolog (TH2-18) from S. cinnamoneus strain TH-2. Although R18 and TH2-18 showed 74% identity in their primary sequence, the recombinant proteins of these two FAEs (rR18 and rTH2-18) showed very different specific activities toward ethyl ferulate...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29147976/evaluation-of-microbial-consortia-and-chemical-changes-in-spontaneous-maize-bran-fermentation
#7
Marilù Decimo, Mattia Quattrini, Giovanni Ricci, Maria Grazia Fortina, Milena Brasca, Tiziana Silvetti, Federica Manini, Daniela Erba, Franca Criscuoli, Maria Cristina Casiraghi
Sustainable exploitation of agro-industrial by-products has attracted great interest in cereal bran valorization. In this research, a polyphasic approach has been carried out to characterize maize bran at microbiological and chemical level during a sourdough like fermentation process, in order to enhance its technological and nutritional properties. Autochthonous microbiota was isolated at different refreshment steps and subjected to identification and molecular characterization. Fermentation was characterized by a rapid increase in lactic acid bacteria and yeasts, with a co-dominance, at the initial stage, of Weissella spp...
November 16, 2017: AMB Express
https://www.readbyqxmd.com/read/29145143/biodegradation-of-polystyrene-wastes-in-yellow-mealworms-larvae-of-tenebrio-molitor-linnaeus-factors-affecting-biodegradation-rates-and-the-ability-of-polystyrene-fed-larvae-to-complete-their-life-cycle
#8
Shan-Shan Yang, Anja Malawi Brandon, James Christopher Andrew Flanagan, Jun Yang, Daliang Ning, Shen-Yang Cai, Han-Qing Fan, Zhi-Yue Wang, Jie Ren, Eric Benbow, Nan-Qi Ren, Robert M Waymouth, Jizhong Zhou, Craig S Criddle, Wei-Min Wu
Commercial production of polystyrene (PS) -a persistent plastic that is not biodegradable at appreciable rates in most environments-has led to its accumulation as a major contaminant of land, rivers, lakes, and oceans. Recently, however, an environment was identified in which PS is susceptible to rapid biodegradation: the larval gut of Tenebrio molitor Linnaeus (yellow mealworms). In this study, we evaluate PS degradation capabilities of a previously untested strain of T. molitor and assess its survival and PS biodegradation rates for a range of conditions (two simulated food wastes, three temperatures, seven PS waste types)...
October 23, 2017: Chemosphere
https://www.readbyqxmd.com/read/29137150/in-vitro-fermentation-patterns-of-rice-bran-components-by-human-gut-microbiota
#9
Tung Pham, Keat Thomas Teoh, Brett J Savary, Ming-Hsuan Chen, Anna McClung, Sun-Ok Lee
Whole grain rice is a rich source of fiber, nutrients, and phytochemicals that may promote gastrointestinal health, but such beneficial components are typically removed with the bran during polishing. Soluble feruloylated arabinoxylan oligosaccharides (FAXO) and polyphenols (RBPP) isolated from rice bran are hypothesized to have positive impacts on human gut microbiota through a prebiotic function. Using an in vitro human fecal fermentation bioassay, FAXO and RBPP treatments were assessed for short-chain fatty acids (SCFA) production patterns and by evaluating their impacts on the phylogentic composition of human gut microbiota by 16S rRNA gene sequencing...
November 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29133187/duddingtonia-flagrans-formulated-in-rice-bran-in-the-control-of-oesophagostomum-spp-intestinal-parasite-of-swine
#10
João Victor Facchini Rodrigues, Fabio Ribeiro Braga, Artur Kanadani Campos, Lorendane Millena de Carvalho, Juliana Milani Araujo, Anderson Rocha Aguiar, Carolina Magri Ferraz, Wendeo Ferreira da Silveira, Marisa Caixetta Valadão, Thais de Oliveira, Samuel Galvão de Freitas, Jackson Victor de Araújo
Three experimental assays with Duddingtonia flagrans (isolated AC001) were carried out. The growth of the genus Duddingtonia present in formulation of rice bran, its predatory capability on Oesophagostomum spp. infective larvae (L3) in petri dishes (assay 1), its action in faecal cultures with eggs of that parasite (assay 2) and isolate's capability of predation after passing through gastrointestinal tract of swine (assay 3) was evaluated. At assay 3, feces were collected at time intervals of 12, 24, 36, 48, and 60 h after feed animals with the formulation...
November 10, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/29127271/whole-grain-consumption-and-risk-of-ischemic-stroke-results-from-2-prospective-cohort-studies
#11
Juan Juan, Gang Liu, Walter C Willett, Frank B Hu, Kathryn M Rexrode, Qi Sun
BACKGROUND AND PURPOSE: Higher intake of whole grains may exert cardiometabolic benefits, although findings on stroke risk are inconclusive. The potentially differential effects of individual whole grain foods on ischemic stroke have not been examined. METHODS: We analyzed whole grain consumption in relation to ischemic stroke among 71 750 women from the Nurses' Health Study and 42 823 men from the Health Professionals Follow-up Study who were free of cardiovascular disease, diabetes mellitus, and cancer at baseline (1984 and 1986, respectively) through 2010 using a Cox proportional hazards model...
November 10, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29110233/preparation-and-application-of-unhairing-enzyme-using-solid-wastes-from-the-leather-industry-an-attempt-toward-internalization-of-solid-wastes-within-the-leather-industry
#12
Renganath Rao Ramesh, Vimudha Muralidharan, Saravanan Palanivel
Usage of the animal fleshing waste as the source of carbon and nitrogen for animal skin unhairing protease (EC 3.4.21) production along with agro-industrial wastes like wheat bran has been investigated. Thermal hydrolysis of delimed fleshing waste for 3 h yielded a fleshing hydrolysate (FH) having a protein content of 20.86 mg/mL and total solids of 46,600 ppm. The FH was lyophilized and spray dried to obtain fleshing hydrolysate powder (FHP) to be used along with wheat bran and rice bran for protease production...
November 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29098581/resistance-of-black-soldier-fly-diptera-stratiomyidae-larvae-to-combined-heavy-metals-and-potential-application-in-municipal-sewage-sludge-treatment
#13
Minmin Cai, Ruiqi Hu, Ke Zhang, Shiteng Ma, Longyu Zheng, Ziniu Yu, Jibin Zhang
Treating municipal sewage sludge (MSS) sustainably and economically in China remains a challenge because of risks associated with the heavy metals it contains. In this study, black solider fly larvae (BSFL) were used for MSS treatment. The resistance of larvae to combined heavy metals and their potential use in conversion of MSS were investigated. The results indicated that seven MSS samples contained large amounts of heavy metals, with the lead and nickel contents of several samples exceeding Chinese national discharge standards...
November 2, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29096258/identification-and-evaluation-of-bioremediation-potential-of-laccase-isoforms-produced-by-cyathus-bulleri-on-wheat-bran
#14
Arpita Vats, Saroj Mishra
Multiplicity in laccases among lignin degrading fungal species is of interest as it confers the ability to degrade several types of lignocellulosics. The combination of laccases produced on such substrates could be beneficial for treatment of complex aromatics, including dyes. In this study, we report on production of high units (679.6Ug(-1) substrate) of laccase on solid wheat bran (WB) by Cyathus bulleri. Laccase, purified from the culture filtrates of WB grown fungus, was effective for oxidation of veratryl alcohol, Reactive blue 21 and textile effluent without assistance of externally added mediators...
October 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29090299/effects-of-the-physical-form-and-the-degree-of-saturation-of-oil-on-postprandial-plasma-triglycerides-glycemia-and-appetite-of-healthy-chinese-adults
#15
Sze-Yen Tan, Elaine Peh, Phei Ching Siow, Alejandro G Marangoni, Christiani Jeyakumar Henry
Ethylcellulose (EC) forms a complex oleogel network that entraps lipids. The digestibility of an oleogel is influenced by the types of oils used in its preparation. This randomised, controlled, crossover study aimed to compare lipidemic, glycemic, and appetitive responses to a test meal alone (no oil control), or to palm oil (PO, 22.25 g), rice bran oil (RBO, 22.25 g), palm oleogel (PG, 22.25 g oil + 2.75 g EC), or rice bran oleogel (RBG, 22.25 g oil + 2.75 g EC). Eighteen healthy Chinese males (age: 28 ± 6 years, weight: 65...
November 1, 2017: Food & Function
https://www.readbyqxmd.com/read/29063186/effects-of-supplementation-with-rice-husk-powder-and-rice-bran-on-inflammatory-factors-in-overweight-and-obese-adults-following-an-energy-restricted-diet-a-randomized-controlled-trial
#16
Fahimeh Edrisi, Mousa Salehi, Afsane Ahmadi, Mohamad Fararoei, Fatemeh Rusta, Salma Mahmodianfard
PURPOSE: Overweight and obesity are major public health concerns worldwide which are associated with a low-grade chronic inflammation. Dietary fiber as an important component of diet could be effective in controlling weight and inflammatory factors. The present study aimed to compare the effects of rice husk powder and rice bran on inflammatory factors along with an energy-restricted diet in overweight and obese adults. METHODS: In this randomized trial, 105 eligible individuals were assigned to one of the three energy-restricted diet groups receiving; rice bran (n = 35), rice husk powder (n = 35), and control group (n = 35) for 12 weeks...
October 23, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29053420/systematic-investigation-of-the-reduction-of-inorganic-arsenic-and-bioactive-nutrients-in-rice-with-various-cooking-techniques
#17
Sang-Ryun Yim, Ji Hyun Kim, Mi-Hee Choi, Ga Young Park, Soon-Mi Shim, Myung-Sub Chung
The objectives of this study were to investigate the effect of polishing, stirring and rinsing, soaking, or pressure-steam cooking on total organic and inorganic arsenic content and to measure daily inorganic arsenic exposure and nutrient values from consumption of rice prepared under the optimal process. With increasing numbers of rinses and times stirred per rinse, the total arsenic content significantly decreased by 27.6% in brown rice and 39.0% in white rice with 10% degree of polishing (10DOP%). The increase in ratio of water to rice from 1...
October 20, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29050420/iron-requirements-of-broiler-breeder-hens
#18
Diogo Taschetto, Sergio Luiz Vieira, Clara Roselina Angel, Catarina Stefanello, Liris Kindlein, Marco Antonio Ebbing, Cristina Tonial Simões
A study was conducted to investigate Fe requirements of broiler breeders. One-hundred-fifty-six Cobb 500 broiler breeder hens were individually placed in electrostatically painted cages at 22 weeks. The study was composed of an adaptation phase, in which hens were fed corn-soy-wheat bran diets until 35 wks. An Fe deficient mash diet (24.6 ppm Fe) was provided from 35 to 46 wk in order to induce a partial body Fe depletion. A production phase followed from 47 to 70 wk when hens were fed 6 diets with increasing Fe sulfate supplementation, which, upon analyses had 24...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29047281/development-of-wheat-bran-oil-concentrates-rich-in-bioactives-with-antioxidant-and-hypolipidemic-properties
#19
Sharanappa T Talawar, Nanishankar V Harohally, Chetana Ramakrishna, G Suresh Kumar
Wheat bran, an abundant byproduct of the milling industry, comprises fat-soluble bioactives and fibers. In the present study, two concentrates were prepared from wheat bran oil (WBO) using silicic acid coupled with acetone (WBA) and hexane (WBH). WBA extract had enhanced color and viscosity and was enriched with fat-soluble bioactives (sterols, oryzanol-like compounds, tocopherols, and carotenoids) as evidenced from NMR and other techniques. In in vitro studies, WBA exhibited significant free radical scavenging activity, limited DNA and LDL oxidation, and inhibiting HMG-CoA reductase and lipase activity better than WBH and WBO...
October 31, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29045796/the-modification-of-the-ketogenic-diet-mitigates-its-stunting-effects-in-rodents
#20
Arkadiusz Damian Liśkiewicz, Daniela Kasprowska-Liśkiewicz, Anna Sługocka, Marta Maria Nowacka-Chmielewska, Jan Wiaderkiewicz, Halina Jędrzejowska-Szypułka, Jarosław Jerzy Barski, Joanna Lewin-Kowalik
The high fat and low carbohydrate ketogenic diet (HFKD) is extensively studied within the fields of numerous diseases, including cancer and neurological disorders. Since most studies incorporate animal models, ensuring the quality of ketogenic rodent diets is important, both in the context of laboratory animal welfare as well as for the accuracy of the obtained results. In this study we implemented a modification to a commonly-used ketogenic rodent chow by replacing non-resorbable cellulose with wheat bran...
October 18, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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