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https://www.readbyqxmd.com/read/28730936/an-industry-update-what-is-the-latest-news-in-therapeutic-delivery
#1
Iain Simpson
This Industry Update covers the period from 1 through 30 April 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. Biogen expanded its portfolio of developmental drugs targeting neurological diseases by licensing a drug from Bristol-Myers Squibb which is currently under investigation for the treatment of progressive supranuclear palsy. Takeda announced a deal with NuBiyota focused on developing treatments for gastrointestinal disorders, based on the manipulation of microbes living in the gut...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28729933/unprovoked-seizures-in-multiple-sclerosis-why-are-they-rare
#2
Anamarija Kavčič, Werner E Hofmann
INTRODUCTION: The frequency of seizures in patients with multiple sclerosis (MS) ranges from 1.5% to 7.8% and is considerably more common than chance events. The etiopathogenesis of seizures in MS is still poorly understood. METHOD: A review of the literature on seizures and MS using PubMed. RESULTS: Cortical gray matter involvement appears to be an all-too-common pathological finding in MS to play a primary role in the pathogenesis of seizures in MS patients...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729888/social-brain-circuitry-and-social-cognition-in-infants-born-preterm
#3
REVIEW
Angela Fenoglio, Michael K Georgieff, Jed T Elison
Preterm birth is associated with an increased risk of adverse neurologic, psychiatric, and cognitive outcomes. The brain circuits involved in processing social information are critical to all of these domains, but little work has been done to examine whether and how these circuits may be especially sensitive to prematurity. This paper contains a brief summary of some of the cognitive, psychiatric, and social outcomes associated with prematurity, followed by a description of findings from the modest body of research into social-cognitive development in infants and children born preterm...
2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28729829/cortex-parcellation-associated-whole-white-matter-parcellation-in-individual-subjects
#4
Patrick Schiffler, Jan-Gerd Tenberge, Heinz Wiendl, Sven G Meuth
The investigation of specific white matter areas is a growing field in neurological research and is typically achieved through the use of atlases. However, the definition of anatomically based regions remains challenging for the white matter and thus hinders region-specific analysis in individual subjects. In this article, we focus on creating a whole white matter parcellation method for individual subjects where these areas can be associated to cortex regions. This is done by combining cortex parcellation and fiber tracking data...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28729755/social-cognition-deficits-current-position-and-future-directions-for-neuropsychological-interventions-in-cerebrovascular-disease
#5
REVIEW
Progress Njomboro
Neuropsychological assessments of cognitive dysfunction in cerebrovascular illness commonly target basic cognitive functions involving aspects of memory, attention, language, praxis, and number processing. Here, I highlight the clinical importance of often-neglected social cognition functions. These functions recruit a widely distributed neural network, making them vulnerable in most cerebrovascular diseases. Sociocognitive deficits underlie most of the problematic social conduct observed in patients and are associated with more negative clinical outcomes (compared to nonsocial cognitive deficits)...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28728893/-%C3%A2-2015-revised-utstein-style-recommended-guidelines-for-uniform-reporting-of-data-from-drowning-related-resuscitation-an-ilcor-advisory-statement
#6
Ahamed H Idris, Joost J L M Bierens, Gavin D Perkins, Volker Wenzel, Vinay Nadkarni, Peter Morley, David S Warner, Alexis Topjian, Allart M Venema, Christine M Branche, David Szpilman, Luiz Morizot-Leite, Masahiko Nitta, Bo Løfgren, Jonathon Webber, Jan-Thorsten Gräsner, Stephen B Beerman, Chun Song Youn, Ulrich Jost, Linda Quan, Cameron Dezfulian, Anthony J Handley, Mary Fran Hazinski
BACKGROUND: Utstein-style guidelines use an established consensus process, endorsed by the international resuscitation community, to facilitate and structure resuscitation research and publication. The first "Guidelines for Uniform Reporting of Data From Drowning" were published over a decade ago. During the intervening years, resuscitation science has advanced considerably, thus making revision of the guidelines timely. In particular, measurement of cardiopulmonary resuscitation elements and neurological outcomes reporting have advanced substantially...
June 23, 2017: Resuscitation
https://www.readbyqxmd.com/read/28728803/neural-foundations-of-creativity-a-systematic-review
#7
Stephanie Mullen Raymond
When considering the importance of the human cognitive function of creativity, we often overlook the fact that it is due to human creativity and to the constant search for new sensory stimuli that our world has, throughout the years, been one of innovation in every aspect of our existence -in the sciences, the humanities, and the arts. Almost everything that surrounds us is the result of human creativity, therefore it is not difficult to understand that although neuroscientific research has led to valuable perceptions into the probable underpinnings of this multifaceted ability, the precise neurological substrates that underlie creativity are yet to be determined...
July 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28728548/social-brain-circuitry-and-social-cognition-in-infants-born-preterm
#8
REVIEW
Angela Fenoglio, Michael K Georgieff, Jed T Elison
Preterm birth is associated with an increased risk of adverse neurologic, psychiatric, and cognitive outcomes. The brain circuits involved in processing social information are critical to all of these domains, but little work has been done to examine whether and how these circuits may be especially sensitive to prematurity. This paper contains a brief summary of some of the cognitive, psychiatric, and social outcomes associated with prematurity, followed by a description of findings from the modest body of research into social-cognitive development in infants and children born preterm...
July 19, 2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28728503/facilitators-and-barriers-to-international-collaboration-in-spinal-cord-injury-results-from-a-survey-of-clinicians-and-researchers
#9
Vanessa K Noonan, Elaine Chan, Kent Bassett-Spiers, David J Berlowitz, Fin Biering-Sørensen, Susan Charlifue, Marnie Graco, Keith C Hayes, Jane Horsewell, Phalgun Joshi, Debora Markelis, Verna Smith, Zeina Waheed, Doug J Brown
International collaboration in spinal cord injury (SCI) clinical research is necessary to overcome the challenges often encountered by clinicians and researchers including participant recruitment, high cost and the need for highly specialized expertise. However, international collaboration poses its own obstacles. The objective of this study was to conduct an international online survey to assess barriers and facilitators to international SCI clinical research, potential initiatives to facilitate future collaborations and the use of SCI-specific data sets and standards...
July 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28728290/-advances-in-research-of-divergence-insufficiency
#10
Y P Li, W Zhang
Divergence insufficiency is acquired esotropia at distance fixation with symptomatic uncrossed diplopia but fusion at near. It can be divided into two forms: primary isolated form and secondary form associated with neurologic abnormalities, also called divergence palsy. The clinical features of divergence insufficiency include small esotropia only at distance but orthotropia or small esophoria at near, comitant deviation at lateral gaze, reduced divergence fusion, full abduction and normal saccadic velocities in abduction...
July 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28727832/neurosurgeon-academic-impact-is-associated-with-clinical-outcomes-after-clipping-of-ruptured-intracranial-aneurysms
#11
Naif M Alotaibi, George M Ibrahim, Justin Wang, Daipayan Guha, Muhammad Mamdani, Tom A Schweizer, R Loch Macdonald
BACKGROUND: Surgeon-dependent factors such as experience and volume are associated with patient outcomes. However, it is unknown whether a surgeon's research productivity could be related to outcomes. The main aim of this study is to investigate the association between the surgeon's academic productivity and clinical outcomes following neurosurgical clipping of ruptured aneurysms. METHODS: We performed a post-hoc analysis of 3567 patients who underwent clipping of ruptured intracranial aneurysms in the randomized trials of tirilazad mesylate from 1990 to 1997...
2017: PloS One
https://www.readbyqxmd.com/read/28726442/ptsd-and-autism-spectrum-disorder-co-morbidity-gaps-in-research-and-potential-shared-mechanisms
#12
Nirit Haruvi-Lamdan, Danny Horesh, Ofer Golan
BACKGROUND: While autism and trauma were often linked in psychoanalytic theory, very few scientific attempts have been made to explore the associations and comorbidity between the two. Instead, each area has grown separately, yielding large bodies of theoretical and clinical knowledge. THEORETICAL FRAMEWORK: In this article, we suggest several possible pathways that may link trauma and autism. First, autism spectrum disorder (ASD) may serve as a vulnerability marker for posttraumatic stress disorder (PTSD), specifically by increasing the risk for exposure to traumatic events...
July 20, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28726260/three-year-experience-with-interventional-neuroradiology-for-management-of-cerebral-aneurysms-at-a-single-australian-centre
#13
Aden McLaughlin, Hal Rice, Laetitia de Viliers, Teresa Withers, David Pearson, Moira Arnell, Kerin Walters, Sarah Czuchwicki, Andrew Bulmer, James Winearls
INTRODUCTION: Over the last decade interventional neuroradiology (NR) has become the mainstay of managing cerebral aneurysms. The aim of our study was to review our growing experiences with interventional NR and quantify morbidity and mortality associated with these procedures. METHODS: The electronic medical records of all patients admitted to the Gold Coast (University) Hospital Intensive Care Unit following subarachnoid haemorrhage (SAH) or elective interventional NR management of cerebral aneurysms between January 2012 and December 2014 were retrieved...
July 20, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28723981/intestinal-microbiota-in-digestive-diseases
#14
Maria do Carmo Friche Passos, Joaquim Prado Moraes-Filho
BACKGROUND: In recent years, especially after the development of sophisticated metagenomic studies, research on the intestinal microbiota has increased, radically transforming our knowledge about the microbiome and its association with health maintenance and disease development in humans. Increasing evidence has shown that a permanent alteration in microbiota composition or function (dysbiosis) can alter immune responses, metabolism, intestinal permeability, and digestive motility, thereby promoting a proinflammatory state...
July 6, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28723825/feasibility-of-conducting-autism-biomarker-research-in-the-clinical-setting
#15
Laura Sices, Katherine Pawlowski, Laura Farfel, Deirdre Phillips, Yamini Howe, David M Cochran, Roula Choueiri, Peter W Forbes, Stephanie J Brewster, Jean A Frazier, Ann Neumeyer, Carolyn Bridgemohan
OBJECTIVE: Recruitment and completion of research activities during regular clinical care has the potential to increase research participation in complex neurodevelopmental disorders. We evaluated the feasibility, and effect on clinical care, of conducting biomarker research within a subspecialty clinical visit for autism spectrum disorder (ASD). METHODS: Children, aged 5 to 10 years, were recruited by providers in ASD clinics at 5 institutions. Biomarkers collected were growth measurements, head circumference, neurologic and dysmorphology examinations, digit ratio (2D:4D) measurement, and platelet serotonin and urinary melatonin sulfate excretion levels...
July 14, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28720769/concentration-dependent-binding-of-small-ligands-to-multiple-saturable-sites-in-membrane-proteins
#16
Letícia Stock, Juliana Hosoume, Werner Treptow
Membrane proteins are primary targets for most therapeutic indications in cancer and neurological diseases, binding over 50% of all known small molecule drugs. Understanding how such ligands impact membrane proteins requires knowledge on the molecular structure of ligand binding, a reasoning that has driven relentless efforts in drug discovery and translational research. Binding of small ligands appears however highly complex involving interaction to multiple transmembrane protein sites featuring single or multiple occupancy states...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719733/characterizing-a-mouse-model-for-evaluation-of-countermeasures-against-hydrogen-sulfide-induced-neurotoxicity-and-neurological-sequelae
#17
Poojya Anantharam, Elizabeth M Whitley, Belinda Mahama, Dong-Suk Kim, Paula M Imerman, Dahai Shao, Monica R Langley, Arthi Kanthasamy, Wilson K Rumbeiha
Hydrogen sulfide (H2 S) is a highly neurotoxic gas. It is the second most common cause of gas-induced deaths. Beyond mortality, surviving victims of acute exposure may suffer long-term neurological sequelae. There is a need to develop countermeasures against H2 S poisoning. However, no translational animal model of H2 S-induced neurological sequelae exists. Here, we describe a novel mouse model of H2 S-induced neurotoxicity for translational research. In paradigm I, C57/BL6 mice were exposed to 765 ppm H2 S for 40 min on day 1, followed by 15-min daily exposures for periods ranging from 1 to 6 days...
July 18, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28716971/2015-revised-utstein-style-recommended-guidelines-for-uniform-reporting-of-data-from-drowning-related-resuscitation-an-ilcor-advisory-statement
#18
REVIEW
Ahamed H Idris, Joost J L M Bierens, Gavin D Perkins, Volker Wenzel, Vinay Nadkarni, Peter Morley, David S Warner, Alexis Topjian, Allart M Venema, Christine M Branche, David Szpilman, Luiz Morizot-Leite, Masahiko Nitta, Bo Løfgren, Jonathon Webber, Jan-Thorsten Gräsner, Stephen B Beerman, Chun Song Youn, Ulrich Jost, Linda Quan, Cameron Dezfulian, Anthony J Handley, Mary Fran Hazinski
BACKGROUND: Utstein-style guidelines use an established consensus process, endorsed by the international resuscitation community, to facilitate and structure resuscitation research and publication. The first "Guidelines for Uniform Reporting of Data From Drowning" were published over a decade ago. During the intervening years, resuscitation science has advanced considerably, thus making revision of the guidelines timely. In particular, measurement of cardiopulmonary resuscitation elements and neurological outcomes reporting have advanced substantially...
July 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28716012/case-reports-of-juvenile-gm1-gangliosidosisis-type-ii-caused-by-mutation-in-glb1-gene
#19
Parvaneh Karimzadeh, Samaneh Naderi, Farzaneh Modarresi, Hassan Dastsooz, Hamid Nemati, Tayebeh Farokhashtiani, Bibi Shahin Shamsian, Soroor Inaloo, Mohammad Ali Faghihi
BACKGROUND: Type II or juvenile GM1-gangliosidosis is an autosomal recessive lysosomal storage disorder, which is clinically distinct from infantile form of the disease by the lack of characteristic cherry-red spot and hepatosplenomegaly. The disease is characterized by slowly progressive neurodegeneration and mild skeletal changes. Due to the later age of onset and uncharacteristic presentation, diagnosis is frequently puzzled with other ataxic and purely neurological disorders. Up to now, 3-4 types of GM1-gangliosidosis have been reported and among them type I is the most common phenotype with the age of onset around 6 months...
July 17, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28715518/early-accurate-diagnosis-and-early-intervention-in-cerebral-palsy-advances-in-diagnosis-and-treatment
#20
Iona Novak, Cathy Morgan, Lars Adde, James Blackman, Roslyn N Boyd, Janice Brunstrom-Hernandez, Giovanni Cioni, Diane Damiano, Johanna Darrah, Ann-Christin Eliasson, Linda S de Vries, Christa Einspieler, Michael Fahey, Darcy Fehlings, Donna M Ferriero, Linda Fetters, Simona Fiori, Hans Forssberg, Andrew M Gordon, Susan Greaves, Andrea Guzzetta, Mijna Hadders-Algra, Regina Harbourne, Angelina Kakooza-Mwesige, Petra Karlsson, Lena Krumlinde-Sundholm, Beatrice Latal, Alison Loughran-Fowlds, Nathalie Maitre, Sarah McIntyre, Garey Noritz, Lindsay Pennington, Domenico M Romeo, Roberta Shepherd, Alicia J Spittle, Marelle Thornton, Jane Valentine, Karen Walker, Robert White, Nadia Badawi
Importance: Cerebral palsy describes the most common physical disability in childhood and occurs in 1 in 500 live births. Historically, the diagnosis has been made between age 12 and 24 months but now can be made before 6 months' corrected age. Objectives: To systematically review best available evidence for early, accurate diagnosis of cerebral palsy and to summarize best available evidence about cerebral palsy-specific early intervention that should follow early diagnosis to optimize neuroplasticity and function...
July 17, 2017: JAMA Pediatrics
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