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Controlled cortical impact AND MRI

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https://www.readbyqxmd.com/read/29128164/grey-matter-volume-loss-is-associated-with-specific-clinical-motor-signs-in-huntington-s-disease
#1
Emma M Coppen, Milou Jacobs, Annette A van den Berg-Huysmans, Jeroen van der Grond, Raymund A C Roos
BACKGROUND: Motor disturbances are clinical hallmarks of Huntington's disease (HD) and involve chorea, dystonia, hypokinesia and visuomotor dysfunction. Investigating the association between specific motor signs and different regional volumes is important to understand the heterogeneity of HD. OBJECTIVE: To investigate the motor phenotype of HD and associations with subcortical and cortical grey matter volume loss. METHODS: Structural T1-weighted MRI scans of 79 HD patients and 30 healthy controls were used to calculate volumes of seven subcortical structures including the nucleus accumbens, hippocampus, thalamus, caudate nucleus, putamen, pallidum and amygdala...
November 2, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29126888/single-severe-traumatic-brain-injury-produces-progressive-pathology-with-ongoing-contralateral-white-matter-damage-one-year-after-injury
#2
Francesca Pischiutta, Edoardo Micotti, Jennifer R Hay, Ines Marongiu, Eliana Sammali, Daniele Tolomeo, Gloria Vegliante, Nino Stocchetti, Gianluigi Forloni, Maria-Grazia De Simoni, William Stewart, Elisa R Zanier
There is increasing recognition that traumatic brain injury (TBI) may initiate long-term neurodegenerative processes, particularly chronic traumatic encephalopathy. However, insight into the mechanisms transforming an initial biomechanical injury into a neurodegenerative process remain elusive, partly as a consequence of the paucity of informative pre-clinical models. This study shows the functional, whole brain imaging and neuropathological consequences at up to one year survival from single severe TBI by controlled cortical impact in mice...
November 7, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29111113/understanding-the-relationship-between-brain-and-upper-limb-function-in-children-with-unilateral-motor-impairments-a-multimodal-approach
#3
Maya Weinstein, Dido Green, Julian Rudisch, Ingar M Zielinski, Marta Benthem-Muñiz, Marijtje L A Jongsma, Verity McClelland, Bert Steenbergen, Shelly Shiran, Dafna Ben Bashat, Gareth J Barker
Atypical brain development and early brain injury have profound and long lasting impact on the development, skill acquisition, and subsequent independence of a child. Heterogeneity is present at the brain level and at the motor level; particularly with respect to phenomena of bilateral activation and mirrored movements (MMs). In this multiple case study we consider the feasibility of using several modalities to explore the relationship between brain structure and/or activity and hand function: Electroencephalography (EEG), both structural and functional Magnetic Resonance Imaging (sMRI, fMRI), diffusion tensor imaging (DTI), transcranial magnetic stimulation (TMS), Electromyography (EMG) and hand function assessments...
October 12, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29103867/impact-of-analgesics-on-executive-function-and-memory-in-the-alzheimer-s-disease-neuroimaging-initiative-database
#4
Lisa Doan, Daniel Choi, Richard Kline
BACKGROUND AND AIMS: Pain is common in older adults but may be undertreated in part due to concerns about medication toxicity. Analgesics may affect cognition. In this retrospective cohort study, we used the Alzheimer's Disease Neuroimaging Initiative (ADNI) database to examine the interaction of cognitive status and medications, especially non-steroidal anti-inflammatory drugs (NSAIDs). We hypothesized NSAID use would be associated with cognition and that this could be mediated through changes in brain structure...
November 2, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29100305/cerebral-blood-flow-changes-in-remitted-early-and-late-onset-depression-patients
#5
Wenxiang Liao, Ze Wang, Xiangrong Zhang, Hao Shu, Zan Wang, Duan Liu, Zhijun Zhang
Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29070666/multiparametric-mri-changes-persist-beyond-recovery-in-concussed-adolescent-hockey-players
#6
Kathryn Y Manning, Amy Schranz, Robert Bartha, Gregory A Dekaban, Christy Barreira, Arthur Brown, Lisa Fischer, Kevin Asem, Timothy J Doherty, Douglas D Fraser, Jeff Holmes, Ravi S Menon
OBJECTIVE: To determine whether multiparametric MRI data can provide insight into the acute and long-lasting neuronal sequelae after a concussion in adolescent athletes. METHODS: Players were recruited from Bantam hockey leagues in which body checking is first introduced (male, age 11-14 years). Clinical measures, diffusion metrics, resting-state network and region-to-region functional connectivity patterns, and magnetic resonance spectroscopy absolute metabolite concentrations were analyzed from an independent, age-matched control group of hockey players (n = 26) and longitudinally in concussed athletes within 24 to 72 hours (n = 17) and 3 months (n = 14) after a diagnosed concussion...
October 25, 2017: Neurology
https://www.readbyqxmd.com/read/28951497/effects-of-dopaminergic-depletion-and-brain-atrophy-on-neuropsychiatric-symptoms-in-de-novo-parkinson-s-disease
#7
Byoung Seok Ye, Seun Jeon, Sohoon Yoon, Seong Woo Kang, KyoungWon Baik, Yoonju Lee, Su Jin Chung, Jungsu S Oh, Hyojeong Moon, Jae Seung Kim, Phil Hyu Lee, Young Ho Sohn
BACKGROUND: Neuropsychiatric symptoms impact the patients' quality of life and caregivers' burdens in Parkinson's disease (PD). We aimed to investigate the effects of striatal dopaminergic depletion and brain atrophy on the neuropsychiatric symptoms of patients with PD. METHODS: Two hundred and seven patients with de novo drug-naïve PD underwent dopamine transporter (DAT) positron emission tomography and brain MRI scanning. In addition, the patients were assessed with caregiver-administered neuropsychiatric inventory (NPI) questionnaires...
September 26, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28899758/chronic-global-analysis-of-vascular-permeability-and-cerebral-blood-flow-after-bone-marrow-stromal-cell-treatment-of-traumatic-brain-injury-in-the-rat-a-long-term-mri-study
#8
Lian Li, Michael Chopp, Guangliang Ding, Qingjiang Li, Asim Mahmood, Quan Jiang
Vascular permeability and hemodynamic alteration in response to the transplantation of human bone marrow stromal cells (hMSCs) after traumatic brain injury (TBI) were longitudinally investigated in non directly injured and normal-appearing cerebral tissue using magnetic resonance imaging (MRI). Male Wistar rats (300-350g, n=30) subjected to controlled cortical impact TBI were intravenously injected with 1ml of saline (at 6-h or 1-week post-injury, n=5/group) or with hMSCs in suspension (∼3×10(6) hMSCs, at 6-h or 1-week post-injury, n=10/group)...
November 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28803512/heterogeneous-pathological-processes-account-for-thalamic-degeneration-in-multiple-sclerosis-insights-from-7%C3%A2-t-imaging
#9
Céline Louapre, Sindhuja T Govindarajan, Costanza Giannì, Nancy Madigan, Jacob A Sloane, Constantina A Treaba, Elena Herranz, Revere P Kinkel, Caterina Mainero
BACKGROUND: Thalamic degeneration impacts multiple sclerosis (MS) prognosis. OBJECTIVE: To investigate heterogeneous thalamic pathology, its correlation with white matter (WM), cortical lesions and thickness, and as function of distance from cerebrospinal fluid (CSF). METHODS: In 41 MS subjects and 17 controls, using 3 and 7 T imaging, we tested for (1) differences in thalamic volume and quantitative T2* (q-T2*) (2) globally and (3) within concentric bands originating from the CSF/thalamus interface; (4) the relation between thalamic, cortical, and WM metrics; and (5) the contribution of magnetic resonance imaging (MRI) metrics to clinical scores...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28756744/personalized-bilateral-whole-body-somatosensory-cortex-stimulation-to-relieve-fatigue-in-multiple-sclerosis
#10
Andrea Cancelli, Carlo Cottone, Alessandro Giordani, Simone Migliore, Domenico Lupoi, Camillo Porcaro, Massimiliano Mirabella, Paolo Maria Rossini, Maria Maddalena Filippi, Franca Tecchio
BACKGROUND: The patients suffering from multiple sclerosis (MS) often consider fatigue the most debilitating symptom they experience, but conventional medicine currently offers poorly efficacious therapies. OBJECTIVE: We executed a replication study of an innovative approach for relieving MS fatigue. METHODS: According to the sample size estimate, we recruited 10 fatigued MS patients who received 5-day transcranial direct current stimulation (tDCS) in a randomized, double-blind, Sham-controlled, crossover study, with modified Fatigue Impact Scale (mFIS) score reduction at the end of the treatment as primary outcome...
July 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28752800/can-resistance-training-impact-mri-outcomes-in-relapsing-remitting-multiple-sclerosis
#11
Tue Kjølhede, Susanne Siemonsen, Damian Wenzel, Jan-Patrick Stellmann, Steffen Ringgaard, Bodil Ginnerup Pedersen, Egon Stenager, Thor Petersen, Kristian Vissing, Christoph Heesen, Ulrik Dalgas
BACKGROUND: Multiple sclerosis (MS) is characterised by accelerated brain atrophy, which relates to disease progression. Previous research shows that progressive resistance training (PRT) can counteract brain atrophy in other populations. OBJECTIVE: To evaluate the effects of PRT by magnetic resonance imaging (MRI) and clinical measures of disease progression in people with MS. METHODS: This study was a 24-week randomised controlled cross-over trial, including a Training ( n = 18, 24 weeks of PRT followed by self-guided physical activity) and Waitlist group ( n = 17, 24 weeks of habitual lifestyle followed by PRT)...
July 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28732352/cerebral-blood-flow-changes-in-remitted-early-and-late-onset-depression-patients
#12
Wenxiang Liao, Ze Wang, Xiangrong Zhang, Hao Shu, Zan Wang, Duan Liu, Zhijun Zhang
Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28672179/the-relevance-of-feature-selection-methods-to-the-classification-of-obsessive-compulsive-disorder-based-on-volumetric-measures
#13
Lucas R Trambaiolli, Claudinei E Biazoli, Joana B Balardin, Marcelo Q Hoexter, João R Sato
BACKGROUND: Magnetic resonance images (MRI) show detectable anatomical and functional differences between individuals with obsessive-compulsive disorder (OCD) and healthy subjects. Moreover, machine learning techniques have been proposed as tools to identify potential biomarkers and, ultimately, to support clinical diagnosis. However, few studies to date have investigated feature selection (FS) influences in OCD MRI-based classification. METHODS: Volumes of cortical and subcortical structures, from MRI data of 38 OCD patients (split into two groups according symptoms severity) and 36 controls, were submitted to seven feature selection algorithms...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28656347/neural-correlates-of-verbal-memory-in-youth-with-heavy-prenatal-alcohol-exposure
#14
Lauren A Gross, Eileen M Moore, Jeffrey R Wozniak, Claire D Coles, Julie A Kable, Elizabeth R Sowell, Kenneth L Jones, Edward P Riley, Sarah N Mattson
Prenatal alcohol exposure can impact both brain development and neurobehavioral function, including verbal learning and recall, although the relation between verbal recall and brain structure in this population has not been examined fully. We aimed to determine the structural neural correlates of verbal learning and recall in youth with histories of heavy prenatal alcohol exposure using a region of interest (ROI) approach. As part of an ongoing multisite project, subjects (age 10-16 years) with prenatal alcohol exposure (AE, n = 81) and controls (CON, n = 81) were tested using the CVLT-C and measures of cortical volume, surface area, and thickness as well as hippocampal volume were derived from MRI...
June 27, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28634048/activation-volume-vs-bold-signal-change-as-measures-of-fmri-activation-its-impact-on-gaba-fmri-activation-correlation
#15
Pallab K Bhattacharyya, Micheal D Phillips, Lael A Stone, Mark J Lowe
PURPOSE: To explore the relative robustness of functional MRI (fMRI) activation volume and blood oxygen level-dependent (BOLD) signal change as fMRI metric, and to study the effect of relative robustness on the correlation between fMRI activation and cortical gamma amino butyric acid (GABA) in healthy controls and patients with multiple sclerosis (MS). METHODS: fMRI data were acquired from healthy controls and patients with MS, with the subjects peforming self paced bilateral finger tapping in block design...
October 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28627714/migraine-subclassification-via-a-data-driven-automated-approach-using-multimodality-factor-mixture-modeling-of-brain-structure-measurements
#16
Todd J Schwedt, Bing Si, Jing Li, Teresa Wu, Catherine D Chong
BACKGROUND: The current subclassification of migraine is according to headache frequency and aura status. The variability in migraine symptoms, disease course, and response to treatment suggest the presence of additional heterogeneity or subclasses within migraine. OBJECTIVE: The study objective was to subclassify migraine via a data-driven approach, identifying latent factors by jointly exploiting multiple sets of brain structural features obtained via magnetic resonance imaging (MRI)...
July 2017: Headache
https://www.readbyqxmd.com/read/28572060/multifocal-tdcs-targeting-the-resting-state-motor-network-increases-cortical-excitability-beyond-traditional-tdcs-targeting-unilateral-motor-cortex
#17
D B Fischer, P J Fried, G Ruffini, O Ripolles, R Salvador, J Banus, W T Ketchabaw, E Santarnecchi, A Pascual-Leone, M D Fox
Scientists and clinicians have traditionally targeted single brain regions with stimulation to modulate brain function and disease. However, brain regions do not operate in isolation, but interact with other regions through networks. As such, stimulation of one region may impact and be impacted by other regions in its network. Here we test whether the effects of brain stimulation can be enhanced by simultaneously targeting a region and its network, identified with resting state functional connectivity MRI. Fifteen healthy participants received two types of transcranial direct current stimulation (tDCS): a traditional two-electrode montage targeting a single brain region (left primary motor cortex [M1]) and a novel eight-electrode montage targeting this region and its associated resting state network...
May 29, 2017: NeuroImage
https://www.readbyqxmd.com/read/28499842/establishing-the-ferret-as-a-gyrencephalic-animal-model-of-traumatic-brain-injury-optimization-of-controlled-cortical-impact-procedures
#18
Susan C Schwerin, Elizabeth B Hutchinson, Kryslaine L Radomski, Kapinga P Ngalula, Carlo M Pierpaoli, Sharon L Juliano
BACKGROUND: Although rodent TBI studies provide valuable information regarding the effects of injury and recovery, an animal model with neuroanatomical characteristics closer to humans may provide a more meaningful basis for clinical translation. The ferret has a high white/gray matter ratio, gyrencephalic neocortex, and ventral hippocampal location. Furthermore, ferrets are amenable to behavioral training, have a body size compatible with pre-clinical MRI, and are cost-effective. NEW METHODS: We optimized the surgical procedure for controlled cortical impact (CCI) using 9 adult male ferrets...
June 15, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28455264/using-functional-and-molecular-mri-techniques-to-detect-neuroinflammation-and-neuroprotection-after-traumatic-brain-injury
#19
Wenzhu Wang, Hong Zhang, Doon-Hoon Lee, Jintao Yu, Tian Cheng, Michael Hong, Shanshan Jiang, Heng Fan, Xi Huang, Jinyuan Zhou, Jian Wang
This study was designed to investigate whether functional and molecular MRI techniques are sensitive biomarkers for assessment of neuroinflammation and drug efficacy after traumatic brain injury (TBI) in rats. We subjected rats to a controlled cortical impact model and used behavioral tests, histology, and immunofluorescence to assess whether flavonoid pinocembrin provides cerebral protection and improves functional recovery. Most importantly, we used multiple noninvasive structural, functional, and molecular MRI techniques to examine whether the pinocembrin-related neuroprotection and attenuation of neuroinflammation can be detected in vivo...
August 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28427472/optimising-conservative-management-of-chronic-low-back-pain-study-protocol-for-a-randomised-controlled-trial
#20
Katherine J Simson, Clint T Miller, Jon Ford, Andrew Hahne, Luana Main, Timo Rantalainen, Wei-Peng Teo, Megan Teychenne, David Connell, Guy Trudel, Guoyan Zheng, Gary Thickbroom, Daniel L Belavy
BACKGROUND: Lower back pain is a global health issue affecting approximately 80% of people at some stage in their life. The current literature suggests that any exercise is beneficial for reducing back pain. However, as pain is a subjective evaluation and physical deficits are evident in low back pain, using it as the sole outcome measure to evaluate superiority of an exercise protocol for low back pain treatment is insufficient. The overarching goal of the current clinical trial is to implement two common, conservative intervention approaches and examine their impact on deficits in chronic low back pain...
April 20, 2017: Trials
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