keyword
https://read.qxmd.com/read/38533783/brain-morphometry-in-former-american-football-players-findings-from-the-diagnose-cte-research-project
#1
JOURNAL ARTICLE
Hector Arciniega, Zachary H Baucom, Fatima Tuz-Zahra, Yorghos Tripodis, Omar John, Holly Carrington, Nicholas Kim, Evdokiya E Knyazhanskaya, Leonard B Jung, Katherine Breedlove, Tim L T Wiegand, Daniel H Daneshvar, R Jarrett Rushmore, Tashrif Billah, Ofer Pasternak, Michael J Coleman, Charles H Adler, Charles Bernick, Laura J Balcer, Michael L Alosco, Inga K Koerte, Alexander P Lin, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Martha E Shenton, Sylvain Bouix
Exposure to repetitive head impacts (RHIs) in contact sports is associated with neurodegenerative disorders including chronic traumatic encephalopathy (CTE) which currently can be diagnosed only at postmortem. American football players are at higher risk of developing CTE given their exposure to RHIs. One promising approach for diagnosing CTE in vivo is to explore known neuropathological abnormalities at postmortem in living individuals using structural magnetic resonance imaging (MRI). MRI brain morphometry was evaluated in 170 male former American football players ages 45-74 years (n = 114 professional; n = 56 college) and 54 same-age unexposed asymptomatic male controls (n = 58 age range 45-74)...
March 27, 2024: Brain
https://read.qxmd.com/read/38496668/a-worldwide-enigma-study-on-epilepsy-related-gray-and-white-matter-compromise-across-the-adult-lifespan
#2
Judy Chen, Alexander Ngo, Raúl Rodríguez-Cruces, Jessica Royer, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S Keller, Fernando Cendes, Clarissa L Yasuda, Marina K M Alvim, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K Focke, Barbara Kreilkamp, Martin Domin, Felix von Podewils, Soenke Langner, Christian Rummel, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Benjamin Bender, Terence J O'Brien, Benjamin Sinclair, Lucy Vivash, Patrick Kwan, Patricia M Desmond, Elaine Lui, Gian Marco Duma, Paolo Bonanni, Alice Ballerini, Anna Elisabetta Vaudano, Stefano Meletti, Manuela Tondelli, Saud Alhusaini, Colin P Doherty, Gianpiero L Cavalleri, Norman Delanty, Reetta Kälviäinen, Graeme D Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Matteo Lenge, Renzo Guerrini, Emanuele Bartolini, Khalid Hamandi, Sonya Foley, Theodor Rüber, Tobias Bauer, Bernd Weber, Benoit Caldairou, Chantal Depondt, Julie Absil, Sarah J A Carr, Eugenio Abela, Mark P Richardson, Orrin Devinsky, Heath Pardoe, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Erik Kaestner, Sean N Hatton, Donatello Arienzo, Sjoerd B Vos, Mina Ryten, Peter N Taylor, John S Duncan, Christopher D Whelan, Marian Galovic, Gavin P Winston, Sophia I Thomopoulos, Paul M Thompson, Sanjay M Sisodiya, Angelo Labate, Carrie R McDonald, Lorenzo Caciagli, Neda Bernasconi, Andrea Bernasconi, Sara Larivière, Dewi Schrader, Boris C Bernhardt
OBJECTIVES: Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of grey and white matter structures. Evidence supports a progressive condition although the temporal evolution of TLE is poorly defined. This ENIGMA-Epilepsy study utilized multimodal magnetic resonance imaging (MRI) data to investigate structural alterations in TLE patients across the adult lifespan. We charted both grey and white matter changes and explored the covariance of age-related alterations in both compartments...
March 6, 2024: bioRxiv
https://read.qxmd.com/read/38495338/the-impact-of-quality-control-on-cortical-morphometry-comparisons-in-autism
#3
JOURNAL ARTICLE
Saashi A Bedford, Alfredo Ortiz-Rosa, Jenna M Schabdach, Manuela Costantino, Stephanie Tullo, Tom Piercy, Meng-Chuan Lai, Michael V Lombardo, Adriana Di Martino, Gabriel A Devenyi, M Mallar Chakravarty, Aaron F Alexander-Bloch, Jakob Seidlitz, Simon Baron-Cohen, Richard A I Bethlehem
Structural magnetic resonance imaging (MRI) quality is known to impact and bias neuroanatomical estimates and downstream analysis, including case-control comparisons, and a growing body of work has demonstrated the importance of careful quality control (QC) and evaluated the impact of image and image-processing quality. However, the growing size of typical neuroimaging datasets presents an additional challenge to QC, which is typically extremely time and labour intensive. One of the most important aspects of MRI quality is the accuracy of processed outputs, which have been shown to impact estimated neurodevelopmental trajectories...
October 1, 2023: Imaging Neurosci (Camb)
https://read.qxmd.com/read/38488444/feature-similarity-gradients-detect-alterations-in-the-neonatal-cortex-associated-with-preterm-birth
#4
JOURNAL ARTICLE
Paola Galdi, Manuel Blesa Cabez, Christine Farrugia, Kadi Vaher, Logan Z J Williams, Gemma Sullivan, David Q Stoye, Alan J Quigley, Antonios Makropoulos, Michael J Thrippleton, Mark E Bastin, Hilary Richardson, Heather Whalley, A David Edwards, Claude J Bajada, Emma C Robinson, James P Boardman
The early life environment programmes cortical architecture and cognition across the life course. A measure of cortical organisation that integrates information from multimodal MRI and is unbound by arbitrary parcellations has proven elusive, which hampers efforts to uncover the perinatal origins of cortical health. Here, we use the Vogt-Bailey index to provide a fine-grained description of regional homogeneities and sharp variations in cortical microstructure based on feature gradients, and we investigate the impact of being born preterm on cortical development at term-equivalent age...
March 2024: Human Brain Mapping
https://read.qxmd.com/read/38482793/identification-and-connectomic-profiling-of-concussion-using-bayesian-machine-learning
#5
JOURNAL ARTICLE
Benjamin Hacker, Phoebe Imms, Ammar M Dharani, Jessica Zhu, Nahian F Chowdhury, Nikhil N Chaudhari, Andrei Irimia
Accurate early diagnosis of concussion is useful to prevent sequelae and improve neurocognitive outcomes. Early after head impact, concussion diagnosis may be doubtful in persons whose neurological, neuroradiological, and/or neurocognitive examinations are equivocal. Such individuals can benefit from novel accurate assessments that complement clinical diagnostics. We introduce a Bayesian machine learning classifier to identify concussion through cortico-cortical connectome mapping from magnetic resonance imaging in persons with quasi-normal cognition and without neuroradiological findings...
March 14, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38478405/causal-role-of-the-frontal-eye-field-in-attention-induced-ocular-dominance-plasticity
#6
JOURNAL ARTICLE
Fangxing Song, Xue Dong, Jiaxu Zhao, Jue Wang, Xiaohui Sang, Xin He, Min Bao
Previous research has found that prolonged eye-based attention can bias ocular dominance. If one eye long-termly views a regular movie meanwhile the opposite eye views a backward movie of the same episode, perceptual ocular dominance will shift towards the eye previously viewing the backward movie. Yet it remains unclear whether the role of eye-based attention in this phenomenon is causal or not. To address this issue, the present study relied on both the functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) techniques...
March 13, 2024: ELife
https://read.qxmd.com/read/38467346/opposite-changes-in-morphometric-similarity-of-medial-reward-and-lateral-non-reward-orbitofrontal-cortex-circuits-in-obesity
#7
JOURNAL ARTICLE
Debo Dong, Ximei Chen, Wei Li, Xiao Gao, Yulin Wang, Feng Zhou, Simon B Eickhoff, Hong Chen
Obesity has a profound impact on metabolic health thereby adversely affecting brain structure and function. However, the majority of previous studies used a single structural index to investigate the link between brain structure and body mass index (BMI), which hinders our understanding of structural covariance between regions in obesity. This study aimed to examine the relationship between macroscale cortical organization and BMI using novel morphometric similarity networks (MSNs). The individual MSNs were first constructed from individual eight multimodal cortical morphometric features between brain regions...
March 10, 2024: NeuroImage
https://read.qxmd.com/read/38465965/dominance-of-tau-burden-in-cortical-over-subcortical-regions-mediates-glymphatic-activity-and-clinical-severity-in-psp
#8
JOURNAL ARTICLE
Jung-Lung Hsu, Yi-Chia Wei, Ing-Tsung Hsiao, Kun-Ju Lin, Tzu-Chen Yen, Chin-Song Lu, Han-Cheng Wang, Alexander Leemans, Yi-Hsin Weng, Kuo-Lun Huang
BACKGROUND: Progressive supranuclear palsy (PSP) is a tauopathy that involves subcortical regions but also extends to cortical areas. The clinical impact of different tau protein sites and their influence on glymphatic dysfunction have not been investigated. PATIENTS AND METHODS: Participants (n = 55; 65.6 ± 7.1 years; 29 women) with PSP (n = 32) and age-matched normal controls (NCs; n = 23) underwent 18F-Florzolotau tau PET, MRI, PSP Rating Scale (PSPRS), and Mini-Mental State Examination...
March 7, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38464316/association-of-long-term-blood-pressure-variability-with-cerebral-amyloid-angiopathy-related-brain-injury-and-cognitive-decline
#9
Lukas Sveikata, Maria Clara Zanon Zotin, Dorothee Schoemaker, Yuan Ma, Valentina Perosa, Anthipa Chokesuwattanaskul, Andreas Charidimou, Marco Duering, Edip M Gurol, Frédéric Assal, Steven M Greenberg, Anand Viswanathan
INTRODUCTION: Long-term systolic blood pressure variability (BPV) has been proposed as a novel risk factor for dementia, but the underlying mechanisms are largely unknown. We aimed to investigate the association between long-term blood pressure variability (BPV), brain injury, and cognitive decline in patients with mild cognitive symptoms and cerebral amyloid angiopathy (CAA), a well-characterized small-vessel disease that causes cognitive decline in older adults. METHODS: Using a prospective memory clinic cohort, we enrolled 102 participants, of whom 52 with probable CAA...
February 27, 2024: medRxiv
https://read.qxmd.com/read/38444775/structural-and-functional-abnormalities-in-the-medial-prefrontal-cortex-were-associated-with-pain-and-depressive-symptoms-in-patients-with-adhesive-capsulitis
#10
JOURNAL ARTICLE
Jie Li, Rui Zhao, Chenguang Wang, Jiajun Song, Xing Guo, Yeqi Ge, Xu Chu
INTRODUCTION: Chronic pain and depression have been shown to coexist in patients with adhesive capsulitis (AC). Recent studies identified the shared brain plasticity between pain and depression; however, how such neuroplasticity contributes to AC remains unclear. Here, we employed a combination of psychophysics, structural MRI, and functional MRI techniques to examine the brain's structural and functional changes in AC. METHODS: Fifty-two patients with AC and 52 healthy controls (HCs) were included in our study...
April 2024: Pain Reports
https://read.qxmd.com/read/38441612/the-cognitive-relevance-of-non-lesional-damage-to-cortical-networks-in-people-with-multiple-sclerosis
#11
JOURNAL ARTICLE
Eva A Krijnen, Tommy A A Broeders, Samantha Noteboom, Maureen van Dam, Albulena Bajrami, Piet M Bouman, Frederik Barkhof, Bernard M J Uitdehaag, Eric C Klawiter, Ismail Koubiyr, Menno M Schoonheim
BACKGROUND: Cognitive impairment, a common and debilitating symptom in people with multiple sclerosis (MS), is especially related to cortical damage. However, the impact of regional cortical damage remains poorly understood. Our aim was to evaluate structural (network) integrity in lesional and non-lesional cortex in people with MS, and its relationship with cognitive dysfunction. METHODS: In this cross-sectional study, 176 people with MS and 48 healthy controls underwent MRI, including double inversion recovery and diffusion-weighted scans, and neuropsychological assessment...
March 5, 2024: Journal of Neurology
https://read.qxmd.com/read/38423537/aberrant-dynamic-functional-connectivity-of-thalamocortical-circuitry-in-major-depressive-disorder
#12
JOURNAL ARTICLE
Weihao Zheng, Qin Zhang, Ziyang Zhao, Pengfei Zhang, Leilei Zhao, Xiaomin Wang, Songyu Yang, Jing Zhang, Zhijun Yao, Bin Hu
Thalamocortical circuitry has a substantial impact on emotion and cognition. Previous studies have demonstrated alterations in thalamocortical functional connectivity (FC), characterized by region-dependent hypo- or hyper-connectivity, among individuals with major depressive disorder (MDD). However, the dynamical reconfiguration of the thalamocortical system over time and potential abnormalities in dynamic thalamocortical connectivity associated with MDD remain unclear. Hence, we analyzed dynamic FC (dFC) between ten thalamic subregions and seven cortical subnetworks from resting-state functional magnetic resonance images of 48 patients with MDD and 57 healthy controls (HCs) to investigate time-varying changes in thalamocortical FC in patients with MDD...
February 24, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38416170/anatomical-correlates-of-apathy-and-impulsivity-co-occurrence-in-early-parkinson-s-disease
#13
JOURNAL ARTICLE
Gianpaolo Maggi, Francis Loayza, Carmine Vitale, Gabriella Santangelo, Ignacio Obeso
BACKGROUND: Although apathy and impulse control disorders (ICDs) are considered to represent opposite extremes of a continuum of motivated behavior (i.e., hypo- and hyperdopaminergic behaviors), they may also co-occur in Parkinson's disease (PD). OBJECTIVES: We aimed to explore the co-occurrence of ICDs and apathy and its neural correlates analyzing gray matter (GM) changes in early untreated PD patients. Moreover, we aimed to investigate the possible longitudinal relationship between ICDs and apathy and their putative impact on cognition during the first five years of PD...
February 28, 2024: Journal of Neurology
https://read.qxmd.com/read/38405701/using-high-resolution-functional-mri-to-differentiate-impacts-of-strabismic-and-anisometropic-amblyopia-on-evoked-ocular-dominance-activity-in-humans
#14
Shahin Nasr, Jan Skerswetat, Eric D Gaier, Sarala N Malladi, Bryan Kennedy, Roger B H Tootell, Peter Bex, David G Hunter
We employed high-resolution functional MRI (fMRI) to distinguish the impacts of anisometropia and strabismus (the two most frequent causes of amblyopia) on the evoked ocular dominance (OD) response. Sixteen amblyopic participants (8 females), comprising 8 individuals with strabismus, 7 with anisometropia, 1 with deprivational amblyopia, along with 8 individuals with normal visual acuity (1 female), participated in this study for whom, we measured the difference between the response to stimulation of the two eyes, across early visual areas (V1-V4)...
February 13, 2024: bioRxiv
https://read.qxmd.com/read/38389222/loneliness-as-neurobehavioral-issue-in-amyotrophic-lateral-sclerosis
#15
JOURNAL ARTICLE
Monica Consonni, Veronica Faltracco, Eleonora Dalla Bella, Alessandra Telesca, Enrica Bersano, Anna Nigri, Greta Demichelis, Jean P Medina, Maria G Bruzzone, Giuseppe Lauria
OBJECTIVE: In elderly people loneliness represents a risk factor for dementia and may negatively impact on mental and physical health. The specific contribute of loneliness to cognitive and behavioral functioning have not yet been determined in amyotrophic lateral sclerosis (ALS). Our hypothesis was that loneliness may be related to motor dysfunction with a negative impact on cognitive and behavioral decline, possibly related to specific cortical involvement. METHODS: In 200 ALS patients (ALSpts) and 50 healthy controls (HCs) we measured loneliness, mood, and quality of life (QoL)...
February 22, 2024: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/38383498/neurotopographical-transformations-dissecting-cortical-reconfigurations-in-auditory-deprivation
#16
JOURNAL ARTICLE
Uttam Kumar, Kalpana Dhanik, Himanshu R Pandey, Mrutyunjaya Mishra, Amit Keshri
Within the intricate matrices of cognitive neuroscience, auditory deprivation acts as a catalyst, propelling a cascade of neuroanatomical adjustments that have, until now, been suboptimally articulated in extant literature. Addressing this gap, our study harnesses high resolution 3T MRI modalities to unveil the multifaceted cortical transformations that emerge in tandem with congenital auditory deficits. We conducted a rigorous cortical surface analysis on a cohort of 90 congenitally deaf individuals, systematically compared to 90 normoacoustic controls...
February 21, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38350048/chronic-active-lesions-and-larger-choroid-plexus-explain-cognition-and-fatigue-in-multiple-sclerosis
#17
JOURNAL ARTICLE
Paolo Preziosa, Elisabetta Pagani, Alessandro Meani, Loredana Storelli, Monica Margoni, Yury Yudin, Nicolò Tedone, Diana Biondi, Martina Rubin, Maria A Rocca, Massimo Filippi
BACKGROUND AND OBJECTIVES: Chronic inflammation may contribute to cognitive dysfunction and fatigue in patients with multiple sclerosis (MS). Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement have been proposed as markers of chronic inflammation in MS being associated with a more severe disease course. However, their relation with cognitive impairment and fatigue has not been fully explored yet. Here, we investigated the contribution of PRL number and volume and CP enlargement to cognitive impairment and fatigue in patients with MS...
March 2024: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/38328104/age-dictates-brain-functional-connectivity-and-axonal-integrity-following-repetitive-mild-traumatic-brain-injuries
#18
Marangelie Criado-Marrero, Sakthivel Ravi, Ekta Bhaskar, Daylin Barroso, Michael A Pizzi, Lakiesha Williams, Cheryl L Wellington, Marcelo Febo, Jose Francisco Abisambra
Traumatic brain injuries (TBI) present a major public health challenge, demanding an in-depth understanding of age-specific signs and vulnerabilities. Aging not only significantly influences brain function and plasticity but also elevates the risk of hospitalizations and death following repetitive mild traumatic brain injuries (rmTBIs). In this study, we investigate the impact of age on brain network changes and white matter properties following rmTBI employing a multi-modal approach that integrates resting-state functional magnetic resonance imaging (rsfMRI), graph theory analysis, diffusion tensor imaging (DTI), and Neurite Orientation Dispersion and Density Imaging (NODDI)...
January 26, 2024: bioRxiv
https://read.qxmd.com/read/38309321/nucleus-basalis-of-meynert-degeneration-predicts-cognitive-decline-in-corticobasal-syndrome
#19
JOURNAL ARTICLE
Daniele Urso, Salvatore Nigro, Benedetta Tafuri, Roberto De Blasi, Joana B Pereira, Giancarlo Logroscino
BACKGROUND: Cognitive changes are common in corticobasal syndrome (CBS) and significantly impact quality of life and caregiver burden. However, there is a scarcity of studies investigating the neural substrates of cognitive changes in CBS, and currently, reliable predictors of cognitive impairment are lacking. The nucleus basalis of Meynert (NbM), which serves as the primary source of cortical cholinergic innervation, has been functionally associated with cognition. This study aimed to explore whether patients with CBS exhibit reduced NbM volumes compared to healthy controls and whether NbM degeneration can serve as a predictor of cognitive impairment in CBS patients...
February 1, 2024: Biological Psychiatry
https://read.qxmd.com/read/38300622/cerebral-cortical-surface-structure-and-neural-activation-pattern-among-adolescent-football-players
#20
JOURNAL ARTICLE
Taylor R Zuidema, Jiancheng Hou, Kyle A Kercher, Grace O Recht, Sage H Sweeney, Nishant Chenchaiah, Hu Cheng, Jesse A Steinfeldt, Keisuke Kawata
IMPORTANCE: Recurring exposure to head impacts in American football has garnered public and scientific attention, yet neurobiological associations in adolescent football players remain unclear. OBJECTIVE: To examine cortical structure and neurophysiological characteristics in adolescent football players. DESIGN, SETTING, AND PARTICIPANTS: This cohort study included adolescent football players and control athletes (swimming, cross country, and tennis) from 5 high school athletic programs, who were matched with age, sex (male), and school...
February 5, 2024: JAMA Network Open
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