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Trabecular risk score

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https://www.readbyqxmd.com/read/28321531/bone-quality-in-beta-thalassemia-intermedia-relationships-with-bone-quantity-and-endocrine-and-hematologic-variables
#1
Marina Baldini, A Marcon, F M Ulivieri, S Seghezzi, R Cassin, C Messina, M D Cappellini, G Graziadei
We report the first evaluation of bone quality in 70 thalassemia intermedia (TI) patients (37 males, 33 females, age 41 ± 12 years). Thirty-three patients (47%) had been transfused, 34 (49%) had been splenectomized, 39 (56%) were on iron chelation therapy, and 11 (16%) were on hydroxyurea. Mean hemoglobin was 9.2 ± 1.5 g/dl, median ferritin 537 ng/dl (range 14-4893), and mean liver iron concentration 7.6 ± 6.4 mg Fe/g dw. Fifteen patients (21%) had endocrinopathies, and 29 (41%) had vitamin D deficiency...
March 20, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28287004/denosumab-reduces-early-migration-in-total-knee-replacement
#2
Håkan Ledin, Lars Good, Per Aspenberg
Background and purpose - Aseptic loosening is a main cause of late revision in total knee replacement (TKR). Migration of implants as measured by radiostereometric analysis (RSA) can predict future loosening. This migration is associated with bone resorption. Denosumab is a human monoclonal antibody that binds to receptors on osteoclast precursors and osteoclasts. This prevents osteoclast formation, resulting in less bone resorption in cortical and trabecular bone. We investigated whether denosumab can reduce migration of TKR, as measured with RSA...
March 13, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28285742/peripheral-quantitative-computed-tomography-pqct-measures-contribute-to-the-understanding-of-bone-fragility-in-older-patients-with-low-trauma-fracture
#3
Hongyuan Jiang, Christopher J Yates, Alexandra Gorelik, Ashwini Kale, Qichun Song, John D Wark
Dual-energy X-ray absorptiometry (DXA) as currently used has limitations in identifying patients with osteoporosis and predicting occurrence of fracture. We aimed to express peripheral quantitative computed tomography (pQCT) variables of patients with low-trauma fracture as T-scores by using T-score scales obtained from healthy young women, and to evaluate the potential clinical utility of pQCT for the assessment of bone fragility. Fracture patients were recruited from a fracture liaison service at the Royal Melbourne Hospital...
March 9, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28276598/clinical-utility-of-using-lumbar-spine-trabecular-bone-score-to-adjust-fracture-probability-the-manitoba-bmd-cohort
#4
P Martineau, W D Leslie, H Johansson, A Oden, E V McCloskey, D Hans, J A Kanis
Decreased lumbar spine trabecular bone score (TBS), a DXA-derived image texture measurement, is a risk factor for major osteoporotic fracture (MOF) and hip fracture (HF) independent of ten-year fracture probability estimated using FRAX(R) . We determined how often applying the TBS adjustment to fracture probability altered treatment qualification. Using a population-based registry containing all clinical DXA results for Manitoba, Canada, we identified 34,316 women with baseline spine and hip DXA, FRAX-based fracture probability measurements (computed with femoral neck bone mineral density), lumbar spine TBS, and minimum 5 years of observation (mean 8...
March 9, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28267045/supplementation-with-2000-iu-of-cholecalciferol-is-associated-with-improvement-of-trabecular-bone-mineral-density-and-muscle-power-in-pediatric-patients-with-ibd
#5
Ondrej Hradsky, Ondrej Soucek, Klara Maratova, Jana Matyskova, Ivana Copova, Kristyna Zarubova, Jiri Bronsky, Zdenek Sumnik
BACKGROUND: Inflammatory bowel diseases (IBD) are associated with altered bone health and increased risk for fractures. Vitamin D deficiency is frequently found in IBD; however, the effect of vitamin D supplementation on bone health of children with IBD is poorly understood. We aimed to observe the changes in volumetric bone density and dynamic muscle functions after vitamin D substitution in a cohort of pediatric patients with IBD. METHODS: This was a prospective observational study of 55 patients (aged 5-19 years) with IBD...
April 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28199411/cortical-porosity-not-superior-to-conventional-densitometry-in-identifying-hemodialysis-patients-with-fragility-fracture
#6
Bernhard Bielesz, Janina M Patsch, Lukas Fischer, Marija Bojic, Wolfgang Winnicki, Michael Weber, Daniel Cejka
Hemodialysis (HD) patients face increased fracture risk, which is further associated with elevated risk of hospitalization and mortality. High-resolution peripheral computed tomography (HR-pQCT) has advanced our understanding of bone disease in chronic kidney disease by characterizing distinct changes in both the cortical and trabecular compartments. Increased cortical porosity (Ct.Po) has been shown to be associated with fracture in patients with osteopenia or in postmenopausal diabetic women. We tested whether the degree of Ct...
2017: PloS One
https://www.readbyqxmd.com/read/28159710/trabecular-bone-score-tbs-method-and-applications
#7
P Martineau, W D Leslie
Trabecular bone score (TBS) is a texture index derived from standard lumbar spine dual energy X-ray absorptiometry (DXA) images and provides information about the underlying bone independent of the bone mineral density (BMD). Several salient observations have emerged. Numerous studies have examined the relationship between TBS and fracture risk and have shown that lower TBS values are associated with increased risk for major osteoporotic fracture in postmenopausal women and older men, with this result being independent of BMD values and other clinical risk factors...
February 1, 2017: Bone
https://www.readbyqxmd.com/read/28131130/trabecular-bone-score-a-new-dxa-derived-measurement-for-fracture-risk-assessment
#8
REVIEW
Barbara C Silva, William D Leslie
Trabecular bone score (TBS) is a novel method that assesses skeletal texture from spine dual-energy X-ray absorptiometry (DXA) images. TBS improves fracture-risk prediction beyond that provided by DXA bone mineral density (BMD) and clinical risk factors, and can be incorporated to the Word Health Organization Fracture Risk Assessment tool (FRAX®) to enhance fracture prediction. There is insufficient evidence that TBS can be used to monitor treatment with bisphosphonates. TBS may be particularly helpful to assess fracture risk in diabetes...
March 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/28127556/trabecular-bone-score-reflects-trabecular-microarchitecture-deterioration-and-fragility-fracture-in-female-adult-patients-receiving-glucocorticoid-therapy-a-pre-post-controlled-study
#9
Mei-Hua Chuang, Tzyy-Ling Chuang, Malcolm Koo, Yuh-Feng Wang
A recently developed diagnostic tool, trabecular bone score (TBS), can provide quality of trabecular microarchitecture based on images obtained from dual-energy X-ray absorptiometry (DXA). Since patients receiving glucocorticoid are at a higher risk of developing secondary osteoporosis, assessment of bone microarchitecture may be used to evaluate risk of fragility fractures of osteoporosis. In this pre-post study of female patients, TBS and fracture risk assessment tool (FRAX) adjusted with TBS (T-FRAX) were evaluated along with bone mineral density (BMD) and FRAX...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28090446/quantitative-imaging-methods-in-osteoporosis
#10
REVIEW
Ling Oei, Fjorda Koromani, Fernando Rivadeneira, M Carola Zillikens, Edwin H G Oei
Osteoporosis is characterized by a decreased bone mass and quality resulting in an increased fracture risk. Quantitative imaging methods are critical in the diagnosis and follow-up of treatment effects in osteoporosis. Prior radiographic vertebral fractures and bone mineral density (BMD) as a quantitative parameter derived from dual-energy X-ray absorptiometry (DXA) are among the strongest known predictors of future osteoporotic fractures. Therefore, current clinical decision making relies heavily on accurate assessment of these imaging features...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28088646/bone-microarchitecture-in-adolescent-boys-with-autism-spectrum-disorder
#11
Ann M Neumeyer, Natalia Cano Sokoloff, Erin McDonnell, Eric A Macklin, Christopher J McDougle, Madhusmita Misra
BACKGROUND: Boys with autism spectrum disorder (ASD) have lower areal bone mineral density (aBMD) than typically developing controls (TDC). Studies of volumetric BMD (vBMD) and bone microarchitecture provide information about fracture risk beyond that provided by aBMD but are currently lacking in ASD. OBJECTIVES: To assess ultradistal radius and distal tibia vBMD, bone microarchitecture and strength estimates in adolescent boys with ASD compared to TDC. DESIGN/METHODS: Cross-sectional study of 34 boys (16 ASD, 18 TDC) that assessed (i) aBMD at the whole body (WB), WB less head (WBLH), hip and spine using dual X-ray absorptiometry (DXA), (ii) vBMD and bone microarchitecture at the ultradistal radius and distal tibia using high-resolution peripheral quantitative CT (HRpQCT), and (iii) bone strength estimates (stiffness and failure load) using micro-finite element analysis (FEA)...
January 11, 2017: Bone
https://www.readbyqxmd.com/read/28071822/responses-to-treatment-with-teriparatide-in-patients-with-atypical-femur-fractures-previously-treated-with-bisphosphonates
#12
Nelson B Watts, Deborah Aggers, Edward F McCarthy, Tina Savage, Stephanie Martinez, Rachel Patterson, Erin Carrithers, Paul D Miller
If over-suppression of bone turnover explained the association between bisphosphonate use and atypical subtrochanteric femur fractures (AFF), this could be reversed with anabolic treatment such as teriparatide. We conducted a prospective, open label study in patients previously treated with bisphosphonates who sustained AFF, examining the response to 24 months treatment with teriparatide on bone mineral density (BMD), trabecular bone score (TBS), bone turnover markers (BTM) and fracture healing as well as quantitative histomorphometry...
January 10, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28039046/bone-quality-assessment-as-measured-by-trabecular-bone-score-in-patients-with-end-stage-renal-disease-on-dialysis
#13
Maria P Yavropoulou, Vasilios Vaios, Maria Pikilidou, Ioannis Chryssogonidis, Melina Sachinidou, Symeon Tournis, Konstantinos Makris, Kalliopi Kotsa, Michalis Daniilidis, Afroditi Haritanti, Vassilios Liakopoulos
Patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD) exhibit osteoporosis and increased fracture risk. Dual-energy X-ray absorptiometry scan measurements and calculation of fracture risk assessment toll score underestimate fracture risk in these patients and do not estimate bone quality. Trabecular bone score (TBS) has been recently proposed as an indirect measure of bone microarchitecture. In this study, we investigated alterations of bone quality in patients with ESRD on HD, using TBS...
December 27, 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/27998716/dxa-30years-and-counting-introduction-to-the-30th-anniversary-issue
#14
E Michael Lewiecki, Neil Binkley
Dual-energy X-ray absorptiometry (DXA) has a colorful history of development and evolution over the past 30years, from early predecessors that were cumbersome and limited in their clinical applications to current elegant instruments with a wide range of uses. DXA is used to diagnose osteoporosis, assess fracture risk, and monitor changes in bone mineral density (BMD). Non-BMD applications include vertebral fracture assessment, measurement of hip geometry, measurement of whole body tissue mass (i.e., bone, fat, and lean mass), abdominal aortic calcification detection and trabecular bone score measurement...
December 17, 2016: Bone
https://www.readbyqxmd.com/read/27951753/novel-imaging-modalities-for-the-comparison-of-bone-microarchitecture-among-hiv-patients-with-and-without-fractures-a-pilot-study
#15
Darrell H S Tan, Janet Raboud, Leah Szadkowski, Eva Szabo, Hanxian Hu, Queenie Wong, Angela M Cheung, Sharon L Walmsley
BACKGROUND: HIV-infected adults have increased fracture risk. OBJECTIVES: To generate pilot data comparing bone density, structure, and strength between HIV-infected adults with and without a prior fracture. METHODS: Adults with and without a prior fracture after their HIV diagnosis were matched 1:1 based on age, sex, race, and smoking history. Participants underwent dual-energy X-ray absorptiometry (DXA), trabecular bone score (TBS), hip structural analyses (HSA), vertebral fracture assessment (VFA), high-resolution peripheral quantitative tomography (HR-pQCT) and measurement of bone turnover markers...
January 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/27933656/change-in-trabecular-bone-score-tbs-with-antiresorptive-therapy-does-not-predict-fracture-in-women-the-manitoba-bmd-cohort
#16
William D Leslie, Sumit R Majumdar, Suzanne N Morin, Didier Hans, Lisa M Lix
Bone mineral density (BMD) and trabecular bone score (TBS), along with additional clinical risk factors, can be used to identify individuals at high fracture risk. Whether change in TBS in untreated or treated women independently affects fracture risk is unclear. Using the Manitoba (Canada) DXA Registry containing all BMD results for the population we identified 9044 women age ≥40 years with two consecutive DXA scans and who were not receiving osteoporosis treatment at baseline (baseline mean age 62 ± 10 years)...
December 8, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27908253/assessment-of-bone-quality-in-osteoporosis-treatment-with-bone-anabolic-agents-really-something-new
#17
Fabio Massimo Ulivieri, Renata Caudarella, Marzia Camisasca, Daniela Maria Cabrini, Ilaria Merli, Carmelo Messina, Luca Petruccio Piodi
Osteoporosis is a chronic pathologic condition, particularly of the elderly, in which a reduction of bone mineral density (BMD) weakens bone, leading to the so-called fragility fractures, most often of spine and femur. The gold standard exam for the quantitative measurement of BMD is the dual X-ray photon absorptiometry (DXA), a radiological method. However, a relevant number of fragility fractures occurs in the range of normal BMD values, meaning that also qualitative aspects of bone play a role, namely bone architecture and bone geometry...
December 1, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27900532/mir-148a-the-epigenetic-regulator-of-bone-homeostasis-is-increased-in-plasma-of-osteoporotic-postmenopausal-women
#18
Ajda Bedene, Simona Mencej Bedrač, Lea Ješe, Janja Marc, Peter Vrtačnik, Janez Preželj, Tomaž Kocjan, Tilen Kranjc, Barbara Ostanek
BACKGROUND: Osteoporosis is a prevalent skeletal disorder characterized by reduced bone mineral density and microarchitectural deterioration of bone tissue, resulting in bone fragility and low-trauma fractures. Imaging techniques are routinely used to detect low bone mass; however, they are unable to identify deterioration of bone quality. Recently, microRNAs have emerged as regulators of bone remodelling and potentially also as a new class of sensitive biomarkers of bone health to aid in diagnosis and treatment monitoring of osteoporosis...
December 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27832795/bone-histomorphometric-changes-in-children-with-rheumatic-disorders-on-chronic-glucocorticoids
#19
Jennifer Harrington, Douglas Holmyard, Earl Silverman, Etienne Sochett, Marc Grynpas
BACKGROUND: Rheumatic diseases are associated with an increased fracture risk. The tissue level characteristics of the bone involvement in children have not been well elucidated. Our objectives were to describe the bone micro-architectural characteristics in children with rheumatic diseases on chronic glucocorticoids, and to determine associations between micro-architectural findings with clinical and radiological variables. METHODS: Children on chronic glucocorticoids for an underlying rheumatic disease were referred for evaluation of bone fragility given the presence of vertebral compression fractures...
November 10, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27797885/trabecular-bone-score-and-incident-fragility-fracture-risk-in-adults-with-reduced-kidney-function
#20
Kyla L Naylor, Jerilynn Prior, Amit X Garg, Claudie Berger, Lisa Langsetmo, Jonathan D Adachi, David Goltzman, Christopher S Kovacs, Robert G Josse, William D Leslie
BACKGROUND AND OBJECTIVES: Trabecular bone score is a gray-level textural measure obtained from dual energy x-ray absorptiometry lumbar spine images that provides information independent of areal bone mineral density. The association between trabecular bone score and incident fractures in adults with reduced kidney function and whether this association differs from that of adults with normal kidney function are unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We included 1426 participants ages ≥40 years old (mean age of 67 years) in the community-based Canadian Multicentre Osteoporosis Study...
November 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
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