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Trabecular risk score

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https://www.readbyqxmd.com/read/27908253/assessment-of-bone-quality-in-osteoporosis-treatment-with-bone-anabolic-agents-really-something-new
#1
Fabio Massimo Ulivieri, Renata Caudarella, Marzia Camisasca, Daniela Maria Cabrini, Ilaria Merli, Carmelo Messina, Luca Petruccio Piodi
Osteoporosis is a chronic pathologic condition, particularly of the elderly, in which a reduction of bone mineral density (BMD) weakens bone, leading to the so-called fragility fractures, most often of spine and femur. The gold standard exam for the quantitative measurement of BMD is the dual X-ray photon absorptiometry (DXA), a radiological method. However, a relevant number of fragility fractures occurs in the range of normal BMD values, meaning that also qualitative aspects of bone play a role, namely bone architecture and bone geometry...
December 1, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27900532/mir-148a-the-epigenetic-regulator-of-bone-homeostasis-is-increased-in-plasma-of-osteoporotic-postmenopausal-women
#2
Ajda Bedene, Simona Mencej Bedrač, Lea Ješe, Janja Marc, Peter Vrtačnik, Janez Preželj, Tomaž Kocjan, Tilen Kranjc, Barbara Ostanek
BACKGROUND: Osteoporosis is a prevalent skeletal disorder characterized by reduced bone mineral density and microarchitectural deterioration of bone tissue, resulting in bone fragility and low-trauma fractures. Imaging techniques are routinely used to detect low bone mass; however, they are unable to identify deterioration of bone quality. Recently, microRNAs have emerged as regulators of bone remodelling and potentially also as a new class of sensitive biomarkers of bone health to aid in diagnosis and treatment monitoring of osteoporosis...
November 29, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27832795/bone-histomorphometric-changes-in-children-with-rheumatic-disorders-on-chronic-glucocorticoids
#3
Jennifer Harrington, Douglas Holmyard, Earl Silverman, Etienne Sochett, Marc Grynpas
BACKGROUND: Rheumatic diseases are associated with an increased fracture risk. The tissue level characteristics of the bone involvement in children have not been well elucidated. Our objectives were to describe the bone micro-architectural characteristics in children with rheumatic diseases on chronic glucocorticoids, and to determine associations between micro-architectural findings with clinical and radiological variables. METHODS: Children on chronic glucocorticoids for an underlying rheumatic disease were referred for evaluation of bone fragility given the presence of vertebral compression fractures...
November 10, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27797885/trabecular-bone-score-and-incident-fragility-fracture-risk-in-adults-with-reduced-kidney-function
#4
Kyla L Naylor, Jerilynn Prior, Amit X Garg, Claudie Berger, Lisa Langsetmo, Jonathan D Adachi, David Goltzman, Christopher S Kovacs, Robert G Josse, William D Leslie
BACKGROUND AND OBJECTIVES: Trabecular bone score is a gray-level textural measure obtained from dual energy x-ray absorptiometry lumbar spine images that provides information independent of areal bone mineral density. The association between trabecular bone score and incident fractures in adults with reduced kidney function and whether this association differs from that of adults with normal kidney function are unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We included 1426 participants ages ≥40 years old (mean age of 67 years) in the community-based Canadian Multicentre Osteoporosis Study...
November 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27788473/not-only-stiffness-but-also-yield-strength-of-the-trabecular-structure-determined-by-non-linear-%C3%A2%C2%B5fe-is-best-predicted-by-bone-volume-fraction-and-fabric-tensor
#5
Sarah N Musy, Ghislain Maquer, Jarunan Panyasantisuk, Jasmin Wandel, Philippe K Zysset
The micro-architecture of cancellous bone is considered a major determinant of the fracture risk. Yet, if morphometry tells about alterations of the trabecular network, its elastic behaviour is best described by bone volume fraction (BV/TV) and the fabric tensor, which gives the anisotropy of the trabecular structure. This remains to be proven for yield strength, the onset of bone failure. The microstructure of 126 samples extracted from femoral heads of two female subjects was evaluated on micro-computed tomography scans via 25 structural indices...
October 14, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27743070/african-americans-have-lower-tbs-than-whites-among-densitometry-patients-at-a-chicago-academic-center
#6
R K Jain, T J Vokes
: Trabecular bone score, an indirect measure of bone structure, may differ between ethnicities. We found that African Americans had lower trabecular bone score than do whites referred for densitometry, even when controlling for age and abdominal soft tissue thickness. PURPOSE: Trabecular bone score (TBS), an indirect measure of bone structure, has been shown to predict fractures in predominantly white populations. Analysis of NHANES data revealed lower TBS in African Americans than in whites...
October 14, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27725999/added-clinical-use-of-trabecular-bone-score-to-bmd-for-major-osteoporotic-fracture-prediction-in-older-chinese-people-the-mr-os-and-ms-os-cohort-study-in-hong-kong
#7
Y Su, J Leung, D Hans, B Aubry-Rozier, T Kwok
: The thresholds of trabecular bone score (TBS) require validation for clinical application in older Chinese people. The lower threshold of TBS significantly improved the accuracy of prediction by bone mineral density-based osteoporosis status for major osteoporotic fracture in older Chinese men. INTRODUCTION: Trabecular bone score (TBS) is a relatively new indicator of skeletal fragility. Its clinical application warrants further investigations. Our aim was to validate and recommend practical thresholds of TBS for fracture prediction in older Chinese people...
October 11, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27722900/comparison-of-trabecular-bone-score-and-hip-structural-analysis-with-frax-%C3%A2-in-postmenopausal-women-with-type-2-diabetes-mellitus
#8
Gloria Bonaccorsi, Enrica Fila, Carmelo Messina, Elisa Maietti, Fabio Massimo Ulivieri, Renata Caudarella, Pantaleo Greco, Giuseppe Guglielmi
PURPOSE: To evaluate (a) the performance in predicting the presence of bone fractures of trabecular bone score (TBS) and hip structural analysis (HSA) in type 2 diabetic postmenopausal women compared to a control group and (b) the fracture prediction ability of TBS versus Fracture Risk Calculator (FRAX(®)) as well as whether TBS can improve the fracture prediction ability of FRAX(®) in diabetic women. METHODS: Eighty diabetic postmenopausal women were matched with 88 controls without major diseases for age and body mass index...
October 8, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27670149/value-of-measuring-bone-microarchitecture-in-fracture-discrimination-in-older-women-with-recent-hip-fracture-a-case-control-study-with-hr-pqct
#9
Tracy Y Zhu, Vivian W Y Hung, Wing-Hoi Cheung, Jack C Y Cheng, Ling Qin, Kwok-Sui Leung
We aimed to determine whether loss of volumetric bone mineral density (vBMD) and deterioration of microarchitecture imaged by high-resolution peripheral quantitative computed tomography at the distal radius/tibia provided additional information in fracture discrimination in postmenopausal women with recent hip fracture. This case-control study involved 24 postmenopausal Chinese women with unilateral femoral neck fracture (average [SD] age: 79.6[5.6]) and 24 age-matched women without any history of fracture...
September 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27595486/ethnic-differences-in-osteoporosis-after-cardiac-transplantation
#10
Rajesh K Jain, Betsy Bennet, Tamara Vokes
Cardiac transplantation is associated with a high risk of fracture. African Americans (AAs) are believed to have a lower risk of osteoporosis than Caucasians, but it is not clear whether they are also protected from osteoporosis resulting from the use of glucocorticoids and/or organ transplantation. We examined possible ethnic differences in 33 cardiac transplant recipients (16 AAs) in a cross-sectional analysis. In addition to bone mineral density and vertebral fracture assessment, we also compared biochemical variables, trabecular bone score, total body dual-energy X-ray absorptiometry, and disability...
August 29, 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/27591864/dxa-based-measurements-in-diabetes-can-they-predict-fracture-risk
#11
G Isanne Schacter, William D Leslie
In the absence of a fragility fracture, osteoporosis is usually diagnosed from bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA). Osteoporosis is an increasingly prevalent disease, as is diabetes [in particular type 2 diabetes (T2D)], in part due to aging populations worldwide. It has been suggested that an increased risk of fracture may be another complication ensuing from longstanding diabetes. The purpose of this review is to concentrate on skeletal parameters and techniques readily available from DXA scanning, and their utility in routine clinical practice for predicting fracture risk...
September 3, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27577725/bone-imaging-in-hypoparathyroidism
#12
B C Silva, M R Rubin, N E Cusano, J P Bilezikian
Hypoparathyroidism (HypoPT) is an uncommon endocrine disorder characterized by chronic deficiency or absence of parathyroid hormone (PTH), which leads to a profound reduction in bone remodeling. Subjects with HypoPT typically have bone mineral densities (BMDs) by dual-energy X-ray absorptiometry (DXA) above average at all skeletal sites, with greatest scores observed at the lumbar spine. Trabecular bone score (TBS), an indirect measure of bone microarchitecture, also appears to be normal in HypoPT. By peripheral quantitative computed tomography (pQCT) of the radius, volumetric BMD at cancellous and cortical compartments, as well as cortical area and thickness, are greater in hypoparathyroid subjects than in controls...
August 30, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27572994/bone-mass-distribution-of-the-distal-tibia-in-normal-osteopenic-and-osteoporotic-conditions-an-ex-vivo-assessment-using-hr-pqct-dxa-and-computational-modelling
#13
Lukas Kamer, Hansrudi Noser, Michael Blauth, Mark Lenz, Markus Windolf, Albrecht W Popp
Osteoporosis leads to bone loss and structural deterioration, which increase the risk of fractures. The aim of this study was to characterize the three-dimensional (3D) bone mass distributions of the distal tibia in normal, osteopenic, and osteoporotic conditions. High-resolution peripheral quantitative computed tomography (HR-pQCT) of the 33 % of the distal tibia and local dual-energy X-ray absorptiometry were applied to 53 intact, fresh-frozen tibiae. The HR-pQCTs were graded to assign local T-scores and merged into three equally sized average normal, osteopenic, and osteoporotic surface models...
August 30, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27565645/the-added-value-of-trabecular-bone-score-to-frax%C3%A2-to-predict-major-osteoporotic-fractures-for-clinical-use-in-chinese-older-people-the-mr-os-and-ms-os-cohort-study-in-hong-kong
#14
Y Su, J Leung, D Hans, O Lamy, T Kwok
: The association of trabecular bone score (TBS) with fracture risk and its added predictive value to FRAX® for clinical use have never been independently evaluated in a Chinese population. TBS may improve the predictive power of FRAX® for clinical use in older Chinese men. INTRODUCTION: Trabecular bone score (TBS) of lumbar spine on Dual X-ray densitometry provides information on bone architecture. We therefore examined the additive value of TBS to FRAX® in predicting major osteoporotic fractures (MOFs) in older Chinese people...
August 26, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27558243/hip-fractures-in-the-elderly-the-role-of-cortical-bone
#15
Umberto Tarantino, Cecilia Rao, Valerio Tempesta, Elena Gasbarra, Maurizio Feola
INTRODUCTION: Osteoporosis is characterised by poor bone quality arising from alterations to trabecular bone. However, recent studies have also described an important role of alterations to cortical bone in the physiopathology of osteoporosis. Although dual-energy X-ray absorptiometry (DXA) is a valid method to assess bone mineral density (BMD), real bone fragility in the presence of comorbidities cannot be evaluated with this method. The aim of this study was to evaluate if cortical thickness could be a good parameter to detect bone fragility in patients with hip fracture, independent of BMD...
August 21, 2016: Injury
https://www.readbyqxmd.com/read/27554425/genetic-determinant-of-trabecular-bone-score-tbs-and-bone-mineral-density-a-bivariate-analysis
#16
Lan T Ho-Pham, Didier Hans, Minh C Doan, Linh D Mai, Tuan V Nguyen
: This study sought to estimate the extent of genetic influence on the variation in trabecular bone score (TBS). We found that genetic factors accounted for ~45% of variance in TBS, and that the co-variation between TBS and bone density is partially determined by genetic factors. INTRODUCTION: Trabecular bone score has emerged as an important predictor of fragility fracture, but factors underlying the individual differences in TBS have not been explored. In this study, we sought to determine the genetic contribution to the variation of TBS in the general population...
November 2016: Bone
https://www.readbyqxmd.com/read/27519968/tbs-and-bmd-at-the-end-of-ai-therapy-a-prospective-study-of-the-b-able-cohort
#17
Rodríguez-Sanz María, Pineda-Moncusí Marta, Servitja Sonia, Garcia-Giralt Natalia, Martos Tamara, Tusquets Ignasi, Martínez-García Maria, Rodriguez-Morera Jaime, Diez-Perez Adolfo, Albanell Joan, Nogués Xavier
INTRODUCTION: Patients with breast cancer under aromatase inhibitor (AI) treatment often develop osteoporosis and their average bone loss rate is twice that of natural reduction during menopause, increasing fracture risk. As the current diagnostic technique based on bone mineral density (BMD) provides no information on bone quality, the Trabecular Bone Score (TBS) has been proposed to reflect bone microarchitecture status. The present study was designed to assess prospective changes in TBS and lumbar spine (LS) BMD in postmenopausal women with breast cancer at completion of AI treatment...
November 2016: Bone
https://www.readbyqxmd.com/read/27481443/the-diabetic-paradox-bone-mineral-density-and-fracture-in-type-2-diabetes
#18
Sonsoles Botella Martínez, Nerea Varo Cenarruzabeitia, Javier Escalada San Martin, Amparo Calleja Canelas
Type 2 diabetes mellitus prevalence and morbidity are increasing. Osteoporotic fractures are among the 'non-classical' complications of diabetes and been overlooked for a long time, maybe because of their complex diagnostic and therapeutic approach. The usual tools for preventing fragility fractures (such as the fracture risk assessment tool and bone densitometry) underestimate risk of fractures in type2 diabetic patients. New techniques, such as trabecular bone score or bone turnover markers, could be useful, but greater scientific evidence is required to recommend their use in clinical practice...
November 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/27467533/bone-density-microarchitecture-and-tissue-quality-long-term-after-kidney-transplant
#19
María José Pérez-Sáez, Sabina Herrera, Daniel Prieto-Alhambra, Xavier Nogués, María Vera, Dolores Redondo-Pachón, Marisa Mir, Roberto Güerri, Marta Crespo, Adolfo Díez-Pérez, Julio Pascual
BACKGROUND: Bone mineral density (BMD) measured by dual-energy x-ray absorptiometry (DXA) is used to assess bone health in kidney transplant recipients (KTR). Trabecular Bone Score (TBS) and in vivo microindentation are novel techniques that directly measure trabecular microarchitecture and mechanical properties of bone at a tissue level and independently predict fracture risk. We tested the bone status of long-term KTR using all 3 techniques. METHODS: Cross-sectional study including 40 KTR with more than 10 years of follow-up and 94 healthy nontransplanted subjects as controls...
July 27, 2016: Transplantation
https://www.readbyqxmd.com/read/27450198/impact-of-lumbar-syndesmophyte-on-bone-health-as-assessed-by-bone-density-bmd-and-bone-texture-tbs-in-men-with-axial-spondyloarthritis
#20
Laura Wildberger, Vladimira Boyadzhieva, Didier Hans, Nikolay Stoilov, Rasho Rashkov, Bérengère Aubry-Rozier
INTRODUCTION: Patients with spondyloarthritis (SpA) have an elevated incidence of osteoporosis and are at increased risk of pathological vertebral fracture. Evaluation of bone density by dual energy X-ray absorptiometry (DXA) has its limits in fracture prediction, already known in this population. One hypothesis is that the presence of lumbar syndesmophyte could overestimate the spine bone mineral density (BMD). Trabecular bone score (TBS) is a new texture measurement correlated with bone microarchitecture...
July 20, 2016: Joint, Bone, Spine: Revue du Rhumatisme
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