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Trabecular risk score

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https://www.readbyqxmd.com/read/29145609/the-differential-effects-of-hiv-and-hcv-on-bone-micro-architecture-and-fracture-risk
#1
Roger J Bedimo, Beverley Adams-Huet, John Poindexter, Geri Brown, Irfan Farukhi, Rosinda Castanon, Diana Turner, Teresa Moore, Pablo Tebas, Naim M Maalouf
Background: HIV/HCV co-infected subjects have a significantly greater osteoporotic fracture risk than HIV-infected, despite the fact that HIV/HCV co-infection has not been associated with lower bone mineral density (BMD) than HIV or HCV alone. We evaluated if changes in bone microarchitecture , measured by trabecular bone score (TBS) could explain these differences. Design: We performed a prospective, cross-sectional cohort study of virologically suppressed HIV, untreated HCV, HIV/HCV co-infected and non-infected controls...
November 14, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29137893/advances-in-the-evaluation-of-bone-health-in-kidney-transplant-patients
#2
María José Pérez-Sáez, Daniel Prieto-Alhambra, Adolfo Díez-Pérez, Julio Pascual
Bone disease related to chronic kidney disease and, particularly, to kidney transplant patients is a common cause or morbidity and mortality, especially due to a higher risk of osteoporotic fractures. Despite the fact that this has been known for decades, to date, an appropriate diagnostic strategy has yet to be established. Apart from bone biopsy, which is invasive and scarcely used, no other technique is available to accurately establish the risk of fracture in kidney patients. Techniques applied to the general population, such as bone densitometry, have not been subjected to sufficient external validation and their use is not systematic...
November 11, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29137106/trabecular-bone-score-as-a-supplementary-tool-for-the-discrimination-of-osteoporotic-fractures-in-postmenopausal-women-with-rheumatoid-arthritis
#3
Yong Jun Choi, Yoon-Sok Chung, Chang-Hee Suh, Ju-Yang Jung, Hyoun-Ah Kim
Rheumatoid arthritis (RA) is a risk factor for bone fragility, and its effect on fracture risk is independent of bone mineral density (BMD). The trabecular bone score (TBS) is a new indirect parameter of bone quality. In this study, BMD and the TBS were compared between female postmenopausal RA patients with and those without vertebral fractures (VFs).This study had a cross-sectional design. Two hundred seventy-nine postmenopausal women with RA aged 50 years or older were included in this study. TBS measurements were performed on the same vertebrae as those for the BMD measurements...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29126119/lower-trabecular-bone-score-in-patients-with-primary-aldosteronism-human-skeletal-deterioration-by-aldosterone-excess
#4
Beom-Jun Kim, Mi Kyung Kwak, Seong Hee Ahn, Hyeonmok Kim, Seung Hun Lee, Jung-Min Koh
Context: Despite the potential detrimental effects of aldosterone excess on bone metabolism, there are discrepancies between fracture risk and bone mass in patients with and without primary aldosteronism (PA). Objective: To clarify the possibility that aldosterone excess may mainly affect bone properties which are not explained by bone mineral density (BMD). Design, Setting, and Patients: Among 625 consecutive patients with newly diagnosed adrenal incidentaloma, 72 patients with biochemically confirmed PA and 335 patients with nonfunctional adrenal incidentaloma were defined as cases and controls, respectively...
November 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29064848/decrease-of-trabecular-bone-score-reflects-severity-of-crohn-s-disease-results-of-a-case-control-study
#5
Anna Krajcovicova, Martin Kuzma, Tibor Hlavaty, Didier Hans, Tomas Koller, Peter Jackuliak, Zuzana Leskova, Igor Sturdik, Zdenko Killinger, Juraj Payer
OBJECTIVES: Osteoporosis and osteopaenia are known chronic complications of inflammatory bowel diseases. The trabecular bone score (TBS) provides an indirect measurement of bone microarchitecture, independent of bone mineral density (BMD). PATIENTS AND METHODS: The study was designed as a case-control study with the aim to assess and compare bone quantity and quality in patients with Crohn's disease (CD). We purposefully excluded postmenopausal women and patients on long-term corticosteroid therapy...
October 23, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29051042/bone-disease-in-primary-hyperparathyroidism
#6
Polyzois Makras, Athanasios D Anastasilakis
Primary hyperparathyroidism (PHPT) is a disease of high bone turnover, decreased bone mineral density (BMD) especially at cortical sites, and increased risk of fractures at all skeletal sites. Early diagnosis during the last decades resulted in milder forms of bone involvement. New methods of imaging and validation such as high resolution peripheral quantitative computed tomography and trabecular bone score provide evidence of disturbed bone microarchitecture and explain further the increased risk of fractures at both cortical and trabecular skeletal sites...
October 16, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29038959/the-effect-of-additional-trabecular-aspiration-to-phacoemulsification-and-trabectome-as-a-triple-procedure-in-pseudoexfoliation-glaucoma-a-case-matched-study
#7
R A Widder, J F Jordan, P Kühnrich, J Luebke, G F Roessler, A Anton
BACKGROUND: Trabectome surgery combined with phacoemulsification is effective in lowering (intraocular pressure) IOP in pseudoexfoliation glaucoma. Trabectome surgery usually aims to remove two to four clock hours of the trabecular meshwork. When adding trabecular aspiration, the remaining meshwork can be treated as well, and therefore 360 degrees of the meshwork can be reached. This study was conducted to investigate the additional benefits and risks of adding trabecular aspiration to the combination of phacoemulsification and trabectome as a triple procedure...
October 16, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29024470/predictive-validity-of-radiographic-trabecular-bone-texture-in-knee-oa-the-oarsi-fnih-oa-biomarkers-consortium
#8
Virginia Byers Kraus, Jamie E Collins, H Cecil Charles, Carl F Pieper, Lawrence Whitley, Elena Losina, Michael Nevitt, Steve Hoffmann, Frank Roemer, Ali Guermazi, David J Hunter
OBJECTIVE: To evaluate radiographic subchondral trabecular bone texture (TBT) as a predictor of clinically relevant osteoarthritis (OA) progression (combination of symptom and structure worsening). METHODS: The FNIH OA Biomarkers Consortium undertook a study of progressive knee OA cases (n=194 knees with both radiographic and pain progression over 24-48 months) and comparators (n=406 OA knees not meeting the case definition). TBT parameters were extracted from a medial subchondral tibial region of interest by fractal signature analysis of radiographs using a validated semi-automated software...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29018923/is-drug-induced-bone-loss-acceptable-in-premenopausal-women-a-practical-fracture-risk-modeling-exercise
#9
N Binkley, R Besuyen, T Fuerst, L Skillern, D Hans
Premenopausal bone loss increases fracture risk later in life. Depending on peak values, varying degrees of bone mass and microarchitectural loss can be tolerated. We suggest that risk-benefit assessments of drugs that cause premenopausal bone loss be individualized considering baseline status and subsequent BMD and TBS loss. INTRODUCTION: It is logical that drug-induced loss of bone mass and microarchitecture in young adults increase fracture risk later in life. However, no existing data quantify how drug-induced bone loss in younger adults impacts fracture risk later in life...
December 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28988401/the-trabecular-bone-score-tbs-complements-dxa-and-the-frax-as-a-fracture-risk-assessment-tool-in-routine-clinical-practice
#10
REVIEW
Didier Hans, Emőke Šteňová, Olivier Lamy
PURPOSE OF THE REVIEW: There is an increasing body of evidence that the trabecular bone score (TBS), a surrogate of bone microarchitecture extracted from spine DXA, could play an important role in the management of patients with osteoporosis or at risk of fracture. The current paper reviews this published body of scientific literature on TBS and answers the most relevant clinical questions. RECENT FINDINGS: TBS has repeatedly been proven to be predictive of fragility fractures, current and future, and this is largely independent of BMD, CRF, and the FRAX, and when used in conjunction with any one of these measures, it consistently enhances their accuracy...
October 7, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28985103/low-bone-mineral-density-in-male-athletes-is-associated-with-bone-stress-injuries-at-anatomic-sites-with-greater-trabecular-composition
#11
Adam S Tenforde, Allyson L Parziale, Kristin L Popp, Kathryn E Ackerman
BACKGROUND: While sports participation is often associated with health benefits, a subset of athletes may develop impaired bone health. Bone stress injuries (BSIs) are a common overuse injury in athletes; site of injury has been shown to relate to underlying bone health in female athletes. Hypothesis/Purpose: This case series characterizes the association of type of sports participation and anatomic site of BSIs with low bone mineral density (BMD), defined as BMD Z-score <-1.0. Similar to female athletes, it was hypothesized that male athletes who participate in running and sustain BSIs in sites of higher trabecular bone content would be more likely to have low BMD...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28965154/trabecular-bone-score-in-men-and-women-with-impaired-fasting-glucose-and-diabetes
#12
Kara L Holloway, Lelia L F De Abreu, Didier Hans, Mark A Kotowicz, Muhammad A Sajjad, Natalie K Hyde, Julie A Pasco
Diabetes is associated with increased skeletal fragility, despite higher bone mineral density (BMD). Alternative measures are necessary to more accurately determine fracture risk in individuals with diabetes. Therefore, we aimed to describe the relationship between trabecular bone score (TBS) and normoglycaemia, impaired fasting glucose (IFG) and diabetes and determine whether TBS-adjusted FRAX (Aus) score differed between these groups. This study included 555 men (68.7 ± 12.2 years) and 514 women (62.0 ± 12...
September 30, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28963163/cemented-total-hip-arthroplasty-following-acetabular-fracture
#13
C E H Scott, D MacDonald, M Moran, T O White, J T Patton, J F Keating
AIMS: To evaluate the outcomes of cemented total hip arthroplasty (THA) following a fracture of the acetabulum, with evaluation of risk factors and comparison with a patient group with no history of fracture. PATIENTS AND METHODS: Between 1992 and 2016, 49 patients (33 male) with mean age of 57 years (25 to 87) underwent cemented THA at a mean of 6.5 years (0.1 to 25) following acetabular fracture. A total of 38 had undergone surgical fixation and 11 had been treated non-operatively; 13 patients died at a mean of 10...
October 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28963079/comparisons-of-tbs-and-lumbar-spine-bmd-in-the-associations-with-vertebral-fractures-according-to-the-t-scores-a-cross-sectional-observation
#14
Jie-Eun Lee, Kyoung Min Kim, Lee-Kyung Kim, Kyong Young Kim, Tae Jung Oh, Jae Hoon Moon, Sung Hee Choi, Soo Lim, Sang Wan Kim, Chan Soo Shin, Hak Chul Jang
Trabecular bone score (TBS) is a parameter of bone quality that has been shown to be related to vertebral fractures. This study aimed to analyze the difference in discriminatory power of TBS for vertebral fractures according to the bone mineral density (BMD) T-score. Areal BMD at the lumbar spine (LS, L1-L4), femur neck (FN) and total hip were assessed using dual x-ray absorptiometry (Discovery W, Hologic, Bedford, MA) in 929 women aged 50years or older. TBS was analyzed using iNsight software (Med-Imaps, Pessac, France)...
September 28, 2017: Bone
https://www.readbyqxmd.com/read/28960489/evaluation-of-radius-microstructure-and-areal-bone-mineral-density-improves-fracture-prediction-in-postmenopausal-women
#15
Emmanuel Biver, Claire Durosier-Izart, Thierry Chevalley, Bert van Rietbergen, René Rizzoli, Serge Ferrari
A majority of low-trauma fractures occurs in subjects with only moderate decrease of areal bone mineral density (aBMD), i.e osteopenia, assessed by dual-energy X-ray absorptiometry (DXA), or low fracture probability assessed by FRAX. We investigated whether peripheral bone microstructure and estimated strength improve the prediction of incident fractures beyond central DXA and FRAX. In this population-based study of 740 postmenopausal women (age 65.0 ± 1.4 years) from the Geneva Retirees Cohort (ISRCTN registry 11865958), we assessed at baseline cortical (Ct) and trabecular (Tb) volumetric bone mineral density (vBMD) and microstructure by peripheral quantitative computed tomography (HR-pQCT), bone strength by micro-finite element analysis, aBMD and trabecular bone score (TBS) by DXA, and FRAX fracture probability...
September 28, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28947370/trabecular-metal-acetabular-components-reduce-the-risk-of-revision-following-primary-total-hip-arthroplasty-a-propensity-score-matched-study-from-the-national-joint-registry-for-england-and-wales
#16
Gulraj S Matharu, Andrew Judge, David W Murray, Hemant G Pandit
BACKGROUND: Trabecular metal (TM)-coated acetabular components are increasingly used in both primary and revision total hip arthroplasty (THA). However, previous studies assessing TM acetabular components have been small single-center cohorts with most lacking a control group. We compared revision rates following primary THA between TM and non-TM-coated acetabular components. METHODS: A retrospective observational study was performed using National Joint Registry data, which included primary THAs with the same cementless acetabular component (either TM or non-TM coated)...
September 5, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28935435/subchondral-tibial-bone-texture-predicts-the-incidence-of-radiographic-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#17
T Janvier, R Jennane, H Toumi, E Lespessailles
OBJECTIVES: To evaluate whether trabecular bone texture (TBT) parameters measured on computed radiographs (CR) could predict the onset of radiographic knee osteoarthritis (OA). MATERIALS AND METHODS: Subjects from the Osteoarthritis Initiative (OAI) with no sign of radiographic OA at baseline were included. Cases that developed either a global radiographic OA defined by the Kellgren-Lawrence (KL) scale, a joint space narrowing (JSN) or tibial osteophytes (TOS) were compared with the controls with no changes after 48 months of follow-up...
September 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28884422/less-strict-intervention-thresholds-for-the-frax-and-tbs-adjusted-frax-predict-clinical-fractures-in-osteopenic-postmenopausal-women-with-no-prior-fractures
#18
Martin Kužma, Didier Hans, Tomáš Koller, Eva Némethová, Peter Jackuliak, Zdenko Killinger, Heinrich Resch, Juraj Payer
Little is known about the clinical relevance of treating post-menopausal women with no prior history of fragility fracture and bone mineral densities (BMD) within the osteopenic range. In recent years, in addition to BMD and FRAX fracture probability assessments, a surrogate measure of bone micro-architecture quality, called the trabecular bone score (TBS), has been proven to predict future fragility fractures independently of both BMD and the FRAX. In this retrospective analysis of a follow-up study, we compared three risk assessment instruments-the FRAX, the TBS, and a TBS-adjusted FRAX score-in their ability, to predict future fragility fractures over a minimum of five years of follow-up among post-menopausal osteopenic women with no prior fragility fractures...
September 7, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28879474/pregnancy-related-fractures-a-retrospective-study-of-a-french-cohort-of-52-patients-and-review-of-the-literature
#19
M Laroche, M Talibart, C Cormier, C Roux, P Guggenbuhl, Y Degboe
A retrospective, multicentre study involving 52 patients was carried out to define the causes and characteristics of pregnancy-related osteoporosis. The mean number of vertebral fractures occurring during the last trimester of pregnancy or at the time of delivery was 3.8. This is often promoted by risk factors before or during pregnancy. INTRODUCTION: In order to define the causes or predisposing factors of pregnancy-related osteoporosis and its clinical, radiological and bone density characteristics, laboratory findings, course and outcome, we carried out a retrospective multicentre study...
November 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28857846/utility-of-trabecular-bone-score-in-the-evaluation-of-osteoporosis
#20
Patrick Martineau, Barbara C Silva, William D Leslie
PURPOSE OF REVIEW: Trabecular bone score (TBS) is a lumbar spine dual-energy absorptiometry texture index which provides information on skeletal quality partially independent of bone mineral density (BMD). A body of work has emerged demonstrating the relationship between TBS and fracture risk, with lower TBS values associated with increased risk for osteoporotic fracture in postmenopausal women and older men. TBS is derived from standard DXA images; however, the information provided by TBS is complementary to that provided by BMD...
December 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
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