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Trabecular risk score

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https://www.readbyqxmd.com/read/29329765/usefulness-of-the-trabecular-bone-score-for-assessing-the-risk-of-osteoporotic-fracture
#1
L Redondo, E Puigoriol, J R Rodríguez, P Peris, E Kanterewicz
INTRODUCTION AND OBJECTIVES: The trabecular bone score (TBS) is an imaging technique that assesses the condition of the trabecular microarchitecture. Preliminary results suggest that TBS, along with the bone mineral density assessment, could improve the calculation of the osteoporotic fracture risk. The aim of this study was to analyse TBS values and their relationship with the clinical characteristics, bone mineral density and history of fractures of a cohort of posmenopausal women. MATERIAL AND METHODS: We analysed 2,257 posmenopausal women from the FRODOS cohort, which was created to determine the risk factors for osteoporotic fracture through a clinical survey and bone densitometry with vertebral morphometry...
January 9, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29322222/urinary-pentosidine-levels-negatively-associates-with-trabecular-bone-scores-in-patients-with-type-2-diabetes-mellitus
#2
Y J Choi, S Y Ock, Y Jin, J S Lee, S H Kim, Y -S Chung
Pentosidine levels were higher in diabetic patients with vertebral fractures. Trabecular bone scores were negatively associated with pentosidine levels in diabetic patients only. Our results provide further evidence that AGEs are associated with the pathogenesis of bone fragility in patients with T2DM. INTRODUCTION: Type 2 diabetes mellitus (T2DM) is associated with fracture risk. Pentosidine, an advanced glycation end product (AGE), is associated with prevalent vertebral fractures (VFs) in patients with T2DM...
January 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29304151/the-role-of-carboxy-terminal-cross-linking-telopeptide-of-type-i-collagen-dual-x-ray-absorptiometry-bone-strain-and-romberg-test-in-a-new-osteoporotic-fracture-risk-evaluation-a-proposal-from-an-observational-study
#3
Fabio M Ulivieri, Luca P Piodi, Enzo Grossi, Luca Rinaudo, Carmelo Messina, Anna P Tassi, Marcello Filopanti, Anna Tirelli, Francesco Sardanelli
The consolidated way of diagnosing and treating osteoporosis in order to prevent fragility fractures has recently been questioned by some papers, which complained of overdiagnosis and consequent overtreatment of this pathology with underestimating other causes of the fragility fractures, like falls. A new clinical approach is proposed for identifying the subgroup of patients prone to fragility fractures. This retrospective observational study was conducted from January to June 2015 at the Nuclear Medicine-Bone Metabolic Unit of the of the Fondazione IRCCS Ca' Granda, Milan, Italy...
2018: PloS One
https://www.readbyqxmd.com/read/29300907/a-6-year-follow-up-of-fracture-incidence-and-volumetric-bone-mineral-density-development-in-girls-with-turner-syndrome
#4
Ondrej Soucek, Eckhard Schönau, Jan Lebl, Johannes Willnecker, Zdenek Hlavka, Zdenek Sumnik
Context: Patients with Turner Syndrome (TS) are at risk of osteoporotic fractures. Objective: The aims of this study were to assess the incidence of clinically significant fractures in girls with TS and prospectively describe the development of volumetric bone mineral density (BMD). Design: Peripheral quantitative computerized tomography (pQCT) of the radius every other year over the 6 years of observation. Setting: Government funded university referral center...
December 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29207490/is-trabecular-bone-score-valuable-in-bone-microstructure-assessment-after-gastric-bypass-in-women-with-morbid-obesity
#5
Agustina Pia Marengo, Fernando Guerrero Pérez, Luis San Martín, Rosa Monseny, Anna Casajoana, Rocio Valera, Nuria Virgili, Andreu Simó Servat, Albert Prats, Carmen Gómez-Vaquero, Nuria Vilarrasa
INTRODUCTION: The effects of bariatric surgery on skeletal health raise many concerns. Trabecular bone score (TBS) is obtained through the analysis of lumbar spine dual X-ray absorptiometry (DXA) images and allows an indirect assessment of skeletal microarchitecture (MA). The aim of our study was to evaluate the changes in bone mineral density (BMD) and alterations in bone microarchitecture assessed by TBS in morbidly obese women undergoing Roux-en-Y gastric bypass (RYGB), over a three-year follow-up...
December 2, 2017: Nutrients
https://www.readbyqxmd.com/read/29207223/-fragility-fracture-in-the-chronic-kidney-disease-ckd
#6
REVIEW
Maria Fusaro, Andrea Aghi, Maria Cristina Mereu, Andrea Giusti
Fragility fractures (FF) are common in patients with chronic kidney disease (CKD), and they occur at a younger age and with a higher frequency than in the general population, producing significant morbidity, mortality and healthcare costs. The pathogenic mechanisms underlying FF in CKD patients have not been completely understood. Behind CKD-MBD, the uremic toxicity should play a role in their pathogenesis, by affecting bone quality (uremic osteoporosis). There are very few prospective studies investigating risk factors for fragility fractures in CKD patients, and available algorithms for fracture risk prediction (FRAX and DeFRA) have never considered CKD...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29172781/fracture-risk-assessment-in-postmenopausal-women-with-diabetes-comparison-between-defra-and-frax-tools
#7
Gloria Bonaccorsi, Carmelo Messina, Carlo Cervellati, Elisa Maietti, Matilde Medini, Maurizio Rossini, Leo Massari, Pantaleo Greco
This study aimed to compare the performance of Fracture Risk Assessment Tool (FRAX) with that of Derived FRAX (DeFRA) in estimating fracture risk in a cohort of type-2 diabetes mellitus (T2DM) postmenopausal women. One hundred nineteen T2DM postmenopausal women and 118 consecutive healthy postmenopausal women were enrolled. Fracture risk was assessed with FRAX (adjusted or non- for trabecular bone score, TBS) and DeFRA. Bone mineral density (BMD) and TBS were evaluated by dual-energy X-ray absorptiometry (DXA)...
November 24, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29170810/correlation-study-between-osteoporosis-and-hematopoiesis-in-the-context-of-adjuvant-chemotherapy-for-breast-cancer
#8
Frédérica Schyrr, Anita Wolfer, Jérôme Pasquier, Anne-Laure Nicoulaz, Olivier Lamy, Olaia Naveiras
This retrospective study attempts to establish if a correlation exists between osteoporosis and hematopoiesis before and after adjuvant chemotherapy in the context of non-metastatic breast cancer. Osteoporosis is interpreted both as a direct marker of osteoblastic decline and as an indirect marker of increased bone marrow adiposity within the hematopoietic microenvironment. Patients from the "Centre du Sein" at CHUV (Centre Hospitalier Universitaire Vaudois) undergoing adjuvant chemotherapy were included in this study...
November 23, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29145609/the-differential-effects-of-hiv-and-hcv-on-bone-micro-architecture-and-fracture-risk
#9
Roger J Bedimo, Beverley Adams-Huet, John Poindexter, Geri Brown, Irfan Farukhi, Rosinda Castanon, Diana Turner, Teresa Moore, Pablo Tebas, Naim M Maalouf
Background: HIV/HCV co-infected subjects have a significantly greater osteoporotic fracture risk than HIV-infected, despite the fact that HIV/HCV co-infection has not been associated with lower bone mineral density (BMD) than HIV or HCV alone. We evaluated if changes in bone microarchitecture , measured by trabecular bone score (TBS) could explain these differences. Design: We performed a prospective, cross-sectional cohort study of virologically suppressed HIV, untreated HCV, HIV/HCV co-infected and non-infected controls...
November 14, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29137893/advances-in-the-evaluation-of-bone-health-in-kidney-transplant-patients
#10
María José Pérez-Sáez, Daniel Prieto-Alhambra, Adolfo Díez-Pérez, Julio Pascual
Bone disease related to chronic kidney disease and, particularly, to kidney transplant patients is a common cause or morbidity and mortality, especially due to a higher risk of osteoporotic fractures. Despite the fact that this has been known for decades, to date, an appropriate diagnostic strategy has yet to be established. Apart from bone biopsy, which is invasive and scarcely used, no other technique is available to accurately establish the risk of fracture in kidney patients. Techniques applied to the general population, such as bone densitometry, have not been subjected to sufficient external validation and their use is not systematic...
November 11, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29137106/trabecular-bone-score-as-a-supplementary-tool-for-the-discrimination-of-osteoporotic-fractures-in-postmenopausal-women-with-rheumatoid-arthritis
#11
Yong Jun Choi, Yoon-Sok Chung, Chang-Hee Suh, Ju-Yang Jung, Hyoun-Ah Kim
Rheumatoid arthritis (RA) is a risk factor for bone fragility, and its effect on fracture risk is independent of bone mineral density (BMD). The trabecular bone score (TBS) is a new indirect parameter of bone quality. In this study, BMD and the TBS were compared between female postmenopausal RA patients with and those without vertebral fractures (VFs).This study had a cross-sectional design. Two hundred seventy-nine postmenopausal women with RA aged 50 years or older were included in this study. TBS measurements were performed on the same vertebrae as those for the BMD measurements...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29126119/lower-trabecular-bone-score-in-patients-with-primary-aldosteronism-human-skeletal-deterioration-by-aldosterone-excess
#12
Beom-Jun Kim, Mi Kyung Kwak, Seong Hee Ahn, Hyeonmok Kim, Seung Hun Lee, Jung-Min Koh
Context: Despite the potential detrimental effects of aldosterone excess on bone metabolism, there are discrepancies between fracture risk and bone mass in patients with and without primary aldosteronism (PA). Objective: To clarify the possibility that aldosterone excess may mainly affect bone properties which are not explained by bone mineral density (BMD). Design, Setting, and Patients: Among 625 consecutive patients with newly diagnosed adrenal incidentaloma, 72 patients with biochemically confirmed PA and 335 patients with nonfunctional adrenal incidentaloma were defined as cases and controls, respectively...
November 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29064848/decrease-of-trabecular-bone-score-reflects-severity-of-crohn-s-disease-results-of-a-case-control-study
#13
Anna Krajcovicova, Martin Kuzma, Tibor Hlavaty, Didier Hans, Tomas Koller, Peter Jackuliak, Zuzana Leskova, Igor Sturdik, Zdenko Killinger, Juraj Payer
OBJECTIVES: Osteoporosis and osteopaenia are known chronic complications of inflammatory bowel diseases. The trabecular bone score (TBS) provides an indirect measurement of bone microarchitecture, independent of bone mineral density (BMD). PATIENTS AND METHODS: The study was designed as a case-control study with the aim to assess and compare bone quantity and quality in patients with Crohn's disease (CD). We purposefully excluded postmenopausal women and patients on long-term corticosteroid therapy...
October 23, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29051042/bone-disease-in-primary-hyperparathyroidism
#14
Polyzois Makras, Athanasios D Anastasilakis
Primary hyperparathyroidism (PHPT) is a disease of high bone turnover, decreased bone mineral density (BMD) especially at cortical sites, and increased risk of fractures at all skeletal sites. Early diagnosis during the last decades resulted in milder forms of bone involvement. New methods of imaging and validation such as high resolution peripheral quantitative computed tomography and trabecular bone score provide evidence of disturbed bone microarchitecture and explain further the increased risk of fractures at both cortical and trabecular skeletal sites...
October 16, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29038959/the-effect-of-additional-trabecular-aspiration-to-phacoemulsification-and-trabectome-as-a-triple-procedure-in-pseudoexfoliation-glaucoma-a-case-matched-study
#15
R A Widder, J F Jordan, P Kühnrich, J Luebke, G F Roessler, A Anton
BACKGROUND: Trabectome surgery combined with phacoemulsification is effective in lowering (intraocular pressure) IOP in pseudoexfoliation glaucoma. Trabectome surgery usually aims to remove two to four clock hours of the trabecular meshwork. When adding trabecular aspiration, the remaining meshwork can be treated as well, and therefore 360 degrees of the meshwork can be reached. This study was conducted to investigate the additional benefits and risks of adding trabecular aspiration to the combination of phacoemulsification and trabectome as a triple procedure...
October 16, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29024470/predictive-validity-of-radiographic-trabecular-bone-texture-in-knee-osteoarthritis-the-osteoarthritis-research-society-international-foundation-for-the-national-institutes-of-health-osteoarthritis-biomarkers-consortium
#16
Virginia Byers Kraus, Jamie E Collins, H Cecil Charles, Carl F Pieper, Lawrence Whitley, Elena Losina, Michael Nevitt, Steve Hoffmann, Frank Roemer, Ali Guermazi, David J Hunter
OBJECTIVE: To evaluate radiographic subchondral trabecular bone texture (TBT) as a predictor of clinically relevant osteoarthritis (OA) progression (combination of symptom and structural worsening). METHODS: The Foundation for the National Institutes of Health (FNIH) OA Biomarkers Consortium undertook a study of progressive knee OA cases (n = 194 knees with both radiographic and pain progression over 24-48 months) and comparators (n = 406 OA knees not meeting the case definition)...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29018923/is-drug-induced-bone-loss-acceptable-in-premenopausal-women-a-practical-fracture-risk-modeling-exercise
#17
N Binkley, R Besuyen, T Fuerst, L Skillern, D Hans
Premenopausal bone loss increases fracture risk later in life. Depending on peak values, varying degrees of bone mass and microarchitectural loss can be tolerated. We suggest that risk-benefit assessments of drugs that cause premenopausal bone loss be individualized considering baseline status and subsequent BMD and TBS loss. INTRODUCTION: It is logical that drug-induced loss of bone mass and microarchitecture in young adults increase fracture risk later in life. However, no existing data quantify how drug-induced bone loss in younger adults impacts fracture risk later in life...
December 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28988401/the-trabecular-bone-score-tbs-complements-dxa-and-the-frax-as-a-fracture-risk-assessment-tool-in-routine-clinical-practice
#18
REVIEW
Didier Hans, Emőke Šteňová, Olivier Lamy
PURPOSE OF THE REVIEW: There is an increasing body of evidence that the trabecular bone score (TBS), a surrogate of bone microarchitecture extracted from spine DXA, could play an important role in the management of patients with osteoporosis or at risk of fracture. The current paper reviews this published body of scientific literature on TBS and answers the most relevant clinical questions. RECENT FINDINGS: TBS has repeatedly been proven to be predictive of fragility fractures, current and future, and this is largely independent of BMD, CRF, and the FRAX, and when used in conjunction with any one of these measures, it consistently enhances their accuracy...
December 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28985103/low-bone-mineral-density-in-male-athletes-is-associated-with-bone-stress-injuries-at-anatomic-sites-with-greater-trabecular-composition
#19
Adam S Tenforde, Allyson L Parziale, Kristin L Popp, Kathryn E Ackerman
BACKGROUND: While sports participation is often associated with health benefits, a subset of athletes may develop impaired bone health. Bone stress injuries (BSIs) are a common overuse injury in athletes; site of injury has been shown to relate to underlying bone health in female athletes. Hypothesis/Purpose: This case series characterizes the association of type of sports participation and anatomic site of BSIs with low bone mineral density (BMD), defined as BMD Z-score <-1.0. Similar to female athletes, it was hypothesized that male athletes who participate in running and sustain BSIs in sites of higher trabecular bone content would be more likely to have low BMD...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28965154/trabecular-bone-score-in-men-and-women-with-impaired-fasting-glucose-and-diabetes
#20
Kara L Holloway, Lelia L F De Abreu, Didier Hans, Mark A Kotowicz, Muhammad A Sajjad, Natalie K Hyde, Julie A Pasco
Diabetes is associated with increased skeletal fragility, despite higher bone mineral density (BMD). Alternative measures are necessary to more accurately determine fracture risk in individuals with diabetes. Therefore, we aimed to describe the relationship between trabecular bone score (TBS) and normoglycaemia, impaired fasting glucose (IFG) and diabetes and determine whether TBS-adjusted FRAX (Aus) score differed between these groups. This study included 555 men (68.7 ± 12.2 years) and 514 women (62.0 ± 12...
September 30, 2017: Calcified Tissue International
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