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Tumor necrotic factor

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https://www.readbyqxmd.com/read/28078129/osteonecrosis-of-the-jaw-associated-with-ziv-aflibercept
#1
Hani Mawardi, Peter Enzinger, Nadine McCleary, Reshma Manon, Alessandro Villa, Nathaniel Treister, Sook-Bin Woo
Medication-related osteonecrosis of the jaw (MRONJ) has been associated with medications that include bisphosphonates (BPs), denosumab, bevacizumab and sunitinib. Ziv-aflibercept is a recombinant human vascular endothelial growth factor (VEGF) receptor which has been used to treat patients with various advanced solid tumors. We report three patients without a history of the use of medications known to cause MRONJ presenting with jaw osteonecrosis typical for MRONJ following therapy with ziv-aflibercept. All patients had metastatic gastrointestinal cancer treated with ziv-aflibercept and were evaluated for MRONJ because of exposed bone in the oral cavity...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28062909/paediatric-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis-an-update-on-renal-management
#2
REVIEW
Lucy A Plumb, Louise Oni, Stephen D Marks, Kjell Tullus
The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a group of disorders characterized by necrotizing inflammation of the small to medium vessels in association with autoantibodies against the cytoplasmic region of the neutrophil. Included in this definition are granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome). AAV are chronic, often relapsing diseases that can be organ or life threatening...
January 6, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28052874/inhibition-of-hdac6-protects-against-rhabdomyolysis-induced-acute-kidney-injury
#3
Shi Yingfeng, Xu Liuqing, Tang Jinhua, Fang Lu, Ma Shuchen, Ma Xiaoyan, Nie Jing, Pi Xiaoling, Qiu Andong, Zhuang Shougang, Liu Na
Histone deacetylase 6 (HDAC6) inhibition has been reported to protect against ischemic stroke and prolong survival after sepsis in animal models. However, it remains unknown whether HDAC6 inhibition offers a renoprotective effect after acute kidney injury (AKI). In this study, we examined the therapeutic effect of tubastatin A (TA), a highly selective inhibitor of HDAC6, on AKI in a murine model of glycerol (GL) injection-induced rhabdomyolysis. Following GL injection, the mice developed severe acute tubular injury as indicated by renal dysfunction, expression of neutrophil gelatinase-associated lipocalin (NGAL), an injury marker of renal tubules and increase of TUNEL positive tubular cells...
January 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27981598/anti-tnf-%C3%AE-for-necrotizing-sarcoid-granulomatosis-of-the-liver
#4
Marcial Sebode, Sören Weidemann, Malte Wehmeyer, Ansgar W Lohse, Christoph Schramm
We present a case of hepatosplenic necrotizing sarcoid granulomatosis, a variant form of "classical" sarcoidosis, that became clinically apparent in the form of multiple hepatic and splenic masses mimicking malignancy. Flow cytometry of intrahepatic T cells isolated from liver biopsy led to the targeted treatment with anti-tumor necrosis factor-alpha (TNF-α) which was highly effective in inducing remission. This article is protected by copyright. All rights reserved.
December 16, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27940163/synergistic-antitumor-efficacy-of-redox-and-ph-dually-responsive-micelleplexes-for-co-delivery-of-camptothecin-and-genes
#5
Maohua Chen, Yun Zhang, Zhoujiang Chen, Songzhi Xie, Xiaoming Luo, Xiaohong Li
: Challenges remain to load and deliver two or multiple drugs of complementary effects for synergistic cancer therapies. In the current study, multiarmed amphiphilic copolymers of 4-arm poly(ethylene glycol) (PEG) and polyaspartate (PAsp) are created for conjugation of camptothecin (CPT) and condensation with tumor necrosis factor-α (TNF) plasmids. Diethylenetriamine (DET) is grafted on PAsp, and CPT is conjugated onto PAsp(DET) by disulfide linkages to form hydrophobic cores of micelles, followed by condensation with TNF plasmids to form micelleplexes...
December 7, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27930350/toll-like-receptor-tlr-4-and-myd88-are-essential-for-atheroprotection-by-peritoneal-b1a-b-cells
#6
Hamid Hosseini, Yi Li, Peter Kanellakis, Christopher Tay, Anh Cao, Edgar Liu, Karlheinz Peter, Peter Tipping, Ban-Hock Toh, Alex Bobik, Tin Kyaw
BACKGROUND: We previously identified peritoneal B1a cells that secrete natural IgM as a key atheroprotective B cell subset. However, the molecules that activate atheroprotective B1a cells are unknown. Here, we investigated whether Toll-like receptors (TLRs) TLR2, TLR4, and TLR9 expressed by B1a cells are required for IgM-mediated atheroprotection. METHODS AND RESULTS: We adoptively transferred B1a cells from wild-type mice or from mice deficient in TLR2, TLR4, TLR9, or myeloid differentiation primary response 88 (MyD88) into ApoE(-/-) mice depleted of peritoneal B1a cells by splenectomy and fed a high-fat diet for 8 weeks...
November 14, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27858493/sp110b-controls-host-immunity-and-susceptibility-to-tuberculosis
#7
Jia-Shiun Leu, Mei-Ling Chen, So-Yi Chang, Sung-Liang Yu, Chia-Wei Lin, Hsuan Wang, Wan-Chen Chen, Chin-Hao Chang, Jann-Yuan Wang, Li-Na Lee, Chong-Jen Yu, Igor Kramnik, Bo-Shiun Yan
RATIONALE: How host genetic factors affect Mycobacterium tuberculosis (Mtb) infection outcomes remains largely unknown. SP110b, an interferon (IFN)-induced nuclear protein, is the nearest human homolog to the mouse Ipr1 protein that has been shown to control host innate immunity to Mtb infection. However, the function(s) of SP110b remain unclear. OBJECTIVES: To elucidate the role of SP110b in controlling the host immunity and susceptibility to tuberculosis (TB) as well as to identify the fundamental immunological and molecular mechanisms affected by SP110b...
November 18, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27849634/inflammation-and-apoptosis-dual-mediator-role-for-toll-like-receptor-4-in-the-development-of-necrotizing-enterocolitis
#8
Yin Zhou, Yibo Li, Bin Zhou, Keling Chen, Zhaoying Lyv, Dongmei Huang, Bin Liu, Zhicheng Xu, Bo Xiang, Shuguang Jin, Xiaofeng Sun, Yuan Li
BACKGROUND: Necrotizing enterocolitis (NEC) is the leading cause of neonatal gastrointestinal mortality; effective interventions are lacking with limited understanding of the pathogenesis of NEC. The importance of Toll-like receptor 4 (TLR4) signaling in NEC is well documented; however, the potential mechanisms that regulate enterocyte inflammation and apoptosis remain unclear. The aim of this study was to characterize the role of TLR4-mediated inflammation and apoptosis in the development of NEC and to determine the major apoptotic pathways and regulators in the process...
January 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27830885/the-protective-role-of-melatonin-on-l-arginine-induced-acute-pancreatitis-in-adult-male-albino-rats
#9
Ahmed S Sadek, Rehab T Khattab
BACKGROUND: Acute pancreatitis (AP) is an inflammatory disease that has an increasing incidence worldwide. It is associated with high morbidity and mortality rates ranging from 15-40% in its severe form. Oxidative stress plays an important role in pancreatic acinar cell injury in case of AP. Melatonin is proven to have both antioxidant and anti-inflammatory effects. The aim of the work was to investigate the protective role of melatonin (Mel) against L-arginine (L-arg)-induced AP in adult male albino rats...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27821803/oncolytic-adenovirus-coexpressing-interleukin-12-and-shvegf-restores-antitumor-immune-function-and-enhances-antitumor-efficacy
#10
Hyo Min Ahn, Jin Woo Hong, Chae-Ok Yun
Tumor microenvironment is extremely immunosuppressive, preventing efficient induction of antitumor immunity. To overcome tumor-mediated immunosuppression and enhance the potency of immunogene therapy, oncolytic adenovirus (Ad) co-expressing interleukin (IL)-12 and vascular endothelial growth factor (VEGF)-specific short hairpin ribonucleic acid (shVEGF; RdB/IL12/shVEGF) was generated. Intratumoral injection of RdB/IL12/shVEGF induced a strong antitumor effect in an immune competent B16-F10 melanoma model. RdB/IL12/shVEGF restored immune surveillance function in tumor tissues and actively recruited immune cells by elevating the expression levels of IL-12 and interferon-γ...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27820817/impact-of-the-b-cell-growth-factor-april-on-the-qualitative-and-immunological-characteristics-of-atherosclerotic-plaques
#11
Sophie J Bernelot Moens, Sander I van Leuven, Kang H Zheng, Stefan R Havik, Miranda V Versloot, Leonie M van Duivenvoorde, Michael Hahne, Erik S G Stroes, Dominique L Baeten, Anouk A J Hamers
Studies on the role of B lymphocytes in atherosclerosis development, have yielded contradictory results. Whereas B lymphocyte-deficiency aggravates atherosclerosis in mice; depletion of mature B lymphocytes reduces atherosclerosis. These observations led to the notion that distinct B lymphocyte subsets have different roles. B1a lymphocytes exert an atheroprotective effect, which has been attributed to secretion of IgM, which can be deposited in atherosclerotic lesions thereby reducing necrotic core formation...
2016: PloS One
https://www.readbyqxmd.com/read/27771058/involvement-of-nf-%C3%AE%C2%BAb-in-regulation-of-actinobacillus-pleuropneumoniae-exotoxin-apxi-induced-proinflammatory-cytokine-production-in-porcine-alveolar-macrophages
#12
Chiung-Wen Hsu, Siou-Cen Li, Nai-Yun Chang, Zeng-Weng Chen, Jiunn-Wang Liao, Ter-Hsin Chen, Jyh-Perng Wang, Jiunn-Horng Lin, Shih-Ling Hsuan
Actinobacillus pleuropneumoniae is a crucial respiratory pathogen that causes fibrinous, hemorrhagic, necrotizing pleuropneumonia in pigs. A. pleuropneumoniae exotoxins (ApxI to IV) are the major virulence factors contributing to A. pleuropneumoniae pathogenesis. Previously, we demonstrated that ApxI induces the expression of proinflammatory cytokines in porcine alveolar macrophages (PAMs) via the mitogen-activated protein kinases (MAPKs) p38 and cJun NH2-terminal kinase (JNK). Nonetheless, the role of nuclear factor (NF)-κB-a transcription factor widely implicated in immune and inflammatory responses-in ApxI-elicited cytokine production has yet to be defined...
November 15, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27739412/induction-of-apoptosis-in-tnf-treated-l929-cells-in-the-presence-of-necrostatin-1
#13
Hirofumi Sawai
It has been shown that necroptosis-caspase-independent programmed necrotic cell death-can be induced by treatment with tumor necrosis factor (TNF) in the L929 murine fibrosarcoma cell line, even in the absence of a caspase inhibitor. Although it was reported that necrostatin-1-a specific inhibitor of necroptosis-inhibited TNF-induced necroptosis in L929 cells, it has not been elucidated whether the cells eventually die by apoptosis in the presence of necrostatin-1. In this paper, induction of apoptosis was demonstrated in TNF-treated L929 cells in the presence of necrostatin-1...
October 7, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27729064/histopathological-analysis-of-spontaneous-large-necrosis-of-adrenal-pheochromocytoma-manifested-as-acute-attacks-of-alternating-hypertension-and-hypotension-a-case-report
#14
Nobumasa Ohara, Yasuyuki Uemura, Naomi Mezaki, Keita Kimura, Masanori Kaneko, Hirohiko Kuwano, Katsuya Ebe, Toshio Fujita, Takeshi Komeyama, Hiroyuki Usuda, Yuto Yamazaki, Takashi Maekawa, Hironobu Sasano, Kenzo Kaneko, Kyuzi Kamoi
BACKGROUND: Pheochromocytomas are rare catecholamine-producing neuroendocrine tumors. Hypertension secondary to pheochromocytoma is often paroxysmal, and patients occasionally present with sudden attacks of alternating hypertension and hypotension. Spontaneous, extensive necrosis within the tumor that is associated with catecholamine crisis is an infrequent complication of adrenal pheochromocytoma, but its pathogenesis remains unclear. CASE PRESENTATION: A 69-year-old Japanese man developed acute-onset episodic headaches, palpitations, and chest pains...
October 12, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27725274/mefunidone-ameliorates-renal-inflammation-and-tubulointerstitial-fibrosis-via-suppression-of-ikk%C3%AE-phosphorylation
#15
Jin Zhang, Linfeng Zheng, Xiangning Yuan, Chunyan Liu, Qiongjing Yuan, Feifei Xie, Sisi Qiu, Zhangzhe Peng, Yiting Tang, Jie Meng, Jiao Qin, Gaoyun Hu, Lijian Tao
Mefunidone is a new pyridone agent that attenuates renal tubulointerstitial fibrosis. However, the signaling pathways involved in the effect of mefunidone on renal tubulointerstitial fibrosis have not been well explained. Inflammatory response initiates and promotes renal tubulointerstitial fibrosis, and the inhibitor of nuclear factor kappa-B kinase beta (IKKβ) is a master regulator of inflammation. This study is determined to clarify the influence of mefunidone on renal inflammation and the phosphorylation of IKKβ...
October 8, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27716154/effect-of-the-herbal-mixture-composed-of-aloe-vera-henna-adiantum-capillus-veneris-and-myrrha-on-wound-healing-in-streptozotocin-induced-diabetic-rats
#16
Hamid Galehdari, Samira Negahdari, Mahnaz Kesmati, Anahita Rezaie, Gholamreza Shariati
BACKGROUND: Wound healing is often impaired in diabetic animals and humans. Matrix metalloproteases act as pro-inflammatory agents in physiological wound healing pathways by stimulating cytokines including the interleukins, IL6, IL1A and IL1B, and the tumor necrosis factor and transforming growth factor beta1. Botanicals are traditionally used to assist healing of different types of wounds, because they produce fewer side effects. Our specific aim here was to develop a plant-based recipe supporting effective wound healing in diabetic animals...
October 6, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27701426/coupled-hybrid-continuum-discrete-model-of-tumor-angiogenesis-and-growth
#17
Jie Lyu, Jinfeng Cao, Peiming Zhang, Yang Liu, Hongtao Cheng
The processes governing tumor growth and angiogenesis are codependent. To study the relationship between them, we proposed a coupled hybrid continuum-discrete model. In this model, tumor cells, their microenvironment (extracellular matrixes, matrix-degrading enzymes, and tumor angiogenic factors), and their network of blood vessels, described by a series of discrete points, were considered. The results of numerical simulation reveal the process of tumor growth and the change in microenvironment from avascular to vascular stage, indicating that the network of blood vessels develops gradually as the tumor grows...
2016: PloS One
https://www.readbyqxmd.com/read/27698775/astragaloside-iv-ameliorates-necrotizing-enterocolitis-by-attenuating-oxidative-stress-and-suppressing-inflammation-via-the-vitamin-d3-upregulated-protein-1-nf-%C3%AE%C2%BAb-signaling-pathway
#18
Zhiyong Cai, Jindi Liu, Hongliang Bian, Jinlan Cai
Astragaloside IV (AS-IV) is a flavonoid from the plant Astragalus membranaceus (Fisch) Bge that has a wide range of therapeutic effects. The aim of the present study was to examine the effect of AS-IV on rats with necrotizing enterocolitis (NEC) under oxidative stress and inflammation. Newborn Sprague-Dawley rats were induced with NEC by asphyxia and hypothermia applied on 3 consecutive days. The rats were orally administered AS-IV at 25, 50 and 75 mg/kg for 4 days. The results revealed that AS-IV administration prevented NEC-induced decrease in the concentration of malondialdehyde and myeloperoxidase, and increase in the activity of glutathione (GSH) and superoxide dismutase in murine models...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27697751/mir-495-functions-as-an-adjuvant-to-radiation-therapy-by-reducing-the-radiation-induced-bystander-effect
#19
Jie Fu, Mengmeng Jiang, Meng Zhang, Jing Zhang, Yu Wang, Shensi Xiang, Xiaojie Xu, Qinong Ye, Haifeng Song
The radiation-induced bystander effect (RIBE) is an important factor in tumor radiation therapy because it may increase the probability of normal cellular injury and the likelihood of secondary cancers after radiotherapy. Here, we identified the role of miR-495 in alleviating RIBEs during radiotherapy. Luciferase reporter assay results confirmed that miR-495 regulated endothelial nitric oxide synthase (eNOS) by targeting the Sp1 3'-untranslated region. Consequently, after radiation, tumor cells expressed less eNOS and Sp1 than controls...
November 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27695480/meroxest-improves-the-prognosis-of-immunocompetent-c57bl-6-mice-with-allografts-of-e0771-mouse-breast-tumor-cells
#20
Esther Carrasco, Jose Manuel Garrido, Pablo Juan Álvarez, Enrique Álvarez-Manzaneda, Rachid Chahboun, Ibtissam Messouri, Consolación Melguizo, Antonia Aránega, Fernando Rodríguez-Serrano
INTRODUCTION: Recently, we have reported the antitumor properties of a new family of synthetic merosesquiterpenes, among which meroxest is highlighted, since it has high activity and specificity for ER(+) breast cancer cells. In this paper, we characterize allografts of ER(+) E0771 mouse breast tumor cells in immunocompetent C57BL/6 mice, and also analyze the effect of meroxest on the prognosis of the disease. MATERIAL AND METHODS: Twenty female C57BL/6 mice were injected with 10(6) E0771 cells...
October 1, 2016: Archives of Medical Science: AMS
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