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Tumor necrotic factor

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https://www.readbyqxmd.com/read/27858493/sp110b-controls-host-immunity-and-susceptibility-to-tuberculosis
#1
Jia-Shiun Leu, Mei-Ling Chen, So-Yi Chang, Sung-Liang Yu, Chia-Wei Lin, Hsuan Wang, Wan-Chen Chen, Chin-Hao Chang, Jann-Yuan Wang, Li-Na Lee, Chong-Jen Yu, Igor Kramnik, Bo-Shiun Yan, Pan-Chyr Yang
RATIONALE: How host genetic factors affect Mycobacterium tuberculosis (Mtb) infection outcomes remains largely unknown. SP110b, an interferon (IFN)-induced nuclear protein, is the nearest human homolog to the mouse Ipr1 protein that has been shown to control host innate immunity to Mtb infection. However, the function(s) of SP110b remain unclear. OBJECTIVES: To elucidate the role of SP110b in controlling the host immunity and susceptibility to tuberculosis (TB) as well as to identify the fundamental immunological and molecular mechanisms affected by SP110b...
November 18, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27849634/inflammation-and-apoptosis-dual-mediator-role-for-toll-like-receptor-4-in-the-development-of-necrotizing-enterocolitis
#2
Yin Zhou, Yibo Li, Bin Zhou, Keling Chen, Zhaoying Lyv, Dongmei Huang, Bin Liu, Zhicheng Xu, Bo Xiang, Shuguang Jin, Xiaofeng Sun, Yuan Li
BACKGROUND: Necrotizing enterocolitis (NEC) is the leading cause of neonatal gastrointestinal mortality; effective interventions are lacking with limited understanding of the pathogenesis of NEC. The importance of Toll-like receptor 4 (TLR4) signaling in NEC is well documented; however, the potential mechanisms that regulate enterocyte inflammation and apoptosis remain unclear. The aim of this study was to characterize the role of TLR4-mediated inflammation and apoptosis in the development of NEC and to determine the major apoptotic pathways and regulators in the process...
November 14, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27830885/the-protective-role-of-melatonin-on-l-arginine-induced-acute-pancreatitis-in-adult-male-albino-rats
#3
Ahmed S Sadek, Rehab T Khattab
BACKGROUND: Acute pancreatitis (AP) is an inflammatory disease that has an increasing incidence worldwide. It is associated with high morbidity and mortality rates ranging from 15-40% in its severe form. Oxidative stress plays an important role in pancreatic acinar cell injury in case of AP. Melatonin is proven to have both antioxidant and anti-inflammatory effects. The aim of the work was to investigate the protective role of melatonin (Mel) against L-arginine (L-arg)-induced AP in adult male albino rats...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27821803/oncolytic-adenovirus-coexpressing-interleukin-12-and-shvegf-restores-antitumor-immune-function-and-enhances-antitumor-efficacy
#4
Hyo Min Ahn, Jin Woo Hong, Chae-Ok Yun
Tumor microenvironment is extremely immunosuppressive, preventing efficient induction of antitumor immunity. To overcome tumor-mediated immunosuppression and enhance the potency of immunogene therapy, oncolytic adenovirus (Ad) co-expressing interleukin (IL)-12 and vascular endothelial growth factor (VEGF)-specific short hairpin ribonucleic acid (shVEGF; RdB/IL12/shVEGF) was generated. Intratumoral injection of RdB/IL12/shVEGF induced a strong antitumor effect in an immune competent B16-F10 melanoma model. RdB/IL12/shVEGF restored immune surveillance function in tumor tissues and actively recruited immune cells by elevating the expression levels of IL-12 and interferon-γ...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27820817/impact-of-the-b-cell-growth-factor-april-on-the-qualitative-and-immunological-characteristics-of-atherosclerotic-plaques
#5
Sophie J Bernelot Moens, Sander I van Leuven, Kang H Zheng, Stefan R Havik, Miranda V Versloot, Leonie M van Duivenvoorde, Michael Hahne, Erik S G Stroes, Dominique L Baeten, Anouk A J Hamers
Studies on the role of B lymphocytes in atherosclerosis development, have yielded contradictory results. Whereas B lymphocyte-deficiency aggravates atherosclerosis in mice; depletion of mature B lymphocytes reduces atherosclerosis. These observations led to the notion that distinct B lymphocyte subsets have different roles. B1a lymphocytes exert an atheroprotective effect, which has been attributed to secretion of IgM, which can be deposited in atherosclerotic lesions thereby reducing necrotic core formation...
2016: PloS One
https://www.readbyqxmd.com/read/27771058/involvement-of-nf-%C3%AE%C2%BAb-in-regulation-of-actinobacillus-pleuropneumoniae-exotoxin-apxi-induced-proinflammatory-cytokine-production-in-porcine-alveolar-macrophages
#6
Chiung-Wen Hsu, Siou-Cen Li, Nai-Yun Chang, Zeng-Weng Chen, Jiunn-Wang Liao, Ter-Hsin Chen, Jyh-Perng Wang, Jiunn-Horng Lin, Shih-Ling Hsuan
Actinobacillus pleuropneumoniae is a crucial respiratory pathogen that causes fibrinous, hemorrhagic, necrotizing pleuropneumonia in pigs. A. pleuropneumoniae exotoxins (ApxI to IV) are the major virulence factors contributing to A. pleuropneumoniae pathogenesis. Previously, we demonstrated that ApxI induces the expression of proinflammatory cytokines in porcine alveolar macrophages (PAMs) via the mitogen-activated protein kinases (MAPKs) p38 and cJun NH2-terminal kinase (JNK). Nonetheless, the role of nuclear factor (NF)-κB-a transcription factor widely implicated in immune and inflammatory responses-in ApxI-elicited cytokine production has yet to be defined...
November 15, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27739412/induction-of-apoptosis-in-tnf-treated-l929-cells-in-the-presence-of-necrostatin-1
#7
Hirofumi Sawai
It has been shown that necroptosis-caspase-independent programmed necrotic cell death-can be induced by treatment with tumor necrosis factor (TNF) in the L929 murine fibrosarcoma cell line, even in the absence of a caspase inhibitor. Although it was reported that necrostatin-1-a specific inhibitor of necroptosis-inhibited TNF-induced necroptosis in L929 cells, it has not been elucidated whether the cells eventually die by apoptosis in the presence of necrostatin-1. In this paper, induction of apoptosis was demonstrated in TNF-treated L929 cells in the presence of necrostatin-1...
October 7, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27729064/histopathological-analysis-of-spontaneous-large-necrosis-of-adrenal-pheochromocytoma-manifested-as-acute-attacks-of-alternating-hypertension-and-hypotension-a-case-report
#8
Nobumasa Ohara, Yasuyuki Uemura, Naomi Mezaki, Keita Kimura, Masanori Kaneko, Hirohiko Kuwano, Katsuya Ebe, Toshio Fujita, Takeshi Komeyama, Hiroyuki Usuda, Yuto Yamazaki, Takashi Maekawa, Hironobu Sasano, Kenzo Kaneko, Kyuzi Kamoi
BACKGROUND: Pheochromocytomas are rare catecholamine-producing neuroendocrine tumors. Hypertension secondary to pheochromocytoma is often paroxysmal, and patients occasionally present with sudden attacks of alternating hypertension and hypotension. Spontaneous, extensive necrosis within the tumor that is associated with catecholamine crisis is an infrequent complication of adrenal pheochromocytoma, but its pathogenesis remains unclear. CASE PRESENTATION: A 69-year-old Japanese man developed acute-onset episodic headaches, palpitations, and chest pains...
October 12, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27725274/mefunidone-ameliorates-renal-inflammation-and-tubulointerstitial-fibrosis-via-suppression-of-ikk%C3%AE-phosphorylation
#9
Jin Zhang, Linfeng Zheng, Xiangning Yuan, Chunyan Liu, Qiongjing Yuan, Feifei Xie, Sisi Qiu, Zhangzhe Peng, Yiting Tang, Jie Meng, Jiao Qin, Gaoyun Hu, Lijian Tao
Mefunidone is a new pyridone agent that attenuates renal tubulointerstitial fibrosis. However, the signaling pathways involved in the effect of mefunidone on renal tubulointerstitial fibrosis have not been well explained. Inflammatory response initiates and promotes renal tubulointerstitial fibrosis, and the inhibitor of nuclear factor kappa-B kinase beta (IKKβ) is a master regulator of inflammation. This study is determined to clarify the influence of mefunidone on renal inflammation and the phosphorylation of IKKβ...
October 8, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27716154/effect-of-the-herbal-mixture-composed-of-aloe-vera-henna-adiantum-capillus-veneris-and-myrrha-on-wound-healing-in-streptozotocin-induced-diabetic-rats
#10
Hamid Galehdari, Samira Negahdari, Mahnaz Kesmati, Anahita Rezaie, Gholamreza Shariati
BACKGROUND: Wound healing is often impaired in diabetic animals and humans. Matrix metalloproteases act as pro-inflammatory agents in physiological wound healing pathways by stimulating cytokines including the interleukins, IL6, IL1A and IL1B, and the tumor necrosis factor and transforming growth factor beta1. Botanicals are traditionally used to assist healing of different types of wounds, because they produce fewer side effects. Our specific aim here was to develop a plant-based recipe supporting effective wound healing in diabetic animals...
October 6, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27701426/coupled-hybrid-continuum-discrete-model-of-tumor-angiogenesis-and-growth
#11
Jie Lyu, Jinfeng Cao, Peiming Zhang, Yang Liu, Hongtao Cheng
The processes governing tumor growth and angiogenesis are codependent. To study the relationship between them, we proposed a coupled hybrid continuum-discrete model. In this model, tumor cells, their microenvironment (extracellular matrixes, matrix-degrading enzymes, and tumor angiogenic factors), and their network of blood vessels, described by a series of discrete points, were considered. The results of numerical simulation reveal the process of tumor growth and the change in microenvironment from avascular to vascular stage, indicating that the network of blood vessels develops gradually as the tumor grows...
2016: PloS One
https://www.readbyqxmd.com/read/27698775/astragaloside-iv-ameliorates-necrotizing-enterocolitis-by-attenuating-oxidative-stress-and-suppressing-inflammation-via-the-vitamin-d3-upregulated-protein-1-nf-%C3%AE%C2%BAb-signaling-pathway
#12
Zhiyong Cai, Jindi Liu, Hongliang Bian, Jinlan Cai
Astragaloside IV (AS-IV) is a flavonoid from the plant Astragalus membranaceus (Fisch) Bge that has a wide range of therapeutic effects. The aim of the present study was to examine the effect of AS-IV on rats with necrotizing enterocolitis (NEC) under oxidative stress and inflammation. Newborn Sprague-Dawley rats were induced with NEC by asphyxia and hypothermia applied on 3 consecutive days. The rats were orally administered AS-IV at 25, 50 and 75 mg/kg for 4 days. The results revealed that AS-IV administration prevented NEC-induced decrease in the concentration of malondialdehyde and myeloperoxidase, and increase in the activity of glutathione (GSH) and superoxide dismutase in murine models...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27697751/mir-495-functions-as-an-adjuvant-to-radiation-therapy-by-reducing-the-radiation-induced-bystander-effect
#13
Jie Fu, Mengmeng Jiang, Meng Zhang, Jing Zhang, Yu Wang, Shensi Xiang, Xiaojie Xu, Qinong Ye, Haifeng Song
The radiation-induced bystander effect (RIBE) is an important factor in tumor radiation therapy because it may increase the probability of normal cellular injury and the likelihood of secondary cancers after radiotherapy. Here, we identified the role of miR-495 in alleviating RIBEs during radiotherapy. Luciferase reporter assay results confirmed that miR-495 regulated endothelial nitric oxide synthase (eNOS) by targeting the Sp1 3'-untranslated region. Consequently, after radiation, tumor cells expressed less eNOS and Sp1 than controls...
October 3, 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27695480/meroxest-improves-the-prognosis-of-immunocompetent-c57bl-6-mice-with-allografts-of-e0771-mouse-breast-tumor-cells
#14
Esther Carrasco, Jose Manuel Garrido, Pablo Juan Álvarez, Enrique Álvarez-Manzaneda, Rachid Chahboun, Ibtissam Messouri, Consolación Melguizo, Antonia Aránega, Fernando Rodríguez-Serrano
INTRODUCTION: Recently, we have reported the antitumor properties of a new family of synthetic merosesquiterpenes, among which meroxest is highlighted, since it has high activity and specificity for ER(+) breast cancer cells. In this paper, we characterize allografts of ER(+) E0771 mouse breast tumor cells in immunocompetent C57BL/6 mice, and also analyze the effect of meroxest on the prognosis of the disease. MATERIAL AND METHODS: Twenty female C57BL/6 mice were injected with 10(6) E0771 cells...
October 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27666654/folic-acid-enhances-the-apoptotic-and-genotoxic-activity-of-carboplatin-in-hela-cell-line
#15
N Nikoloff, M V Ponzinibbio, G Padula, J C De Luca, C D Golijow, A Seoane
In human tumor cells, experimental and clinical evidence indicates that some factors involved in signal transduction and cell growth can also modulate the response to chemotherapeutic treatment. The aim of the present study was to investigate the role of folic acid (FA) as a modulator of carboplatin (CBDCA) activity. Genotoxicity and cytotoxicity induced by CBDCA alone and in combination with FA were assessed in cultured HeLa cells. We used comet assay, mitotic index analysis, MTT and NR assays, cytokinesis-block micronucleus cytome assay and annexin V-IP as different cytotoxicity and genotoxicity approaches for human cervical carcinoma cell line studies...
December 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27648614/necrotic-bone-stimulates-proinflammatory-responses-in-macrophages-through-the-activation-of-toll-like-receptor-4
#16
Naga Suresh Adapala, Ryosuke Yamaguchi, Matthew Phipps, Olumide Aruwajoye, Harry K W Kim
In children with Legg-Calvé-Perthes disease, loss of blood supply to the femoral head results in ischemic osteonecrosis. Generally, macrophages play important roles in the inflammatory response to tissue necrosis, but their role in ischemic osteonecrosis of the femoral head (ONFH) is not known. The purpose of this study was to determine the macrophage-inflammatory responses after ONFH and the receptor mechanisms involved in sensing the necrotic bone, using a piglet model of Legg-Calvé-Perthes disease. Induction of ONFH resulted in increased numbers of CD14(+) macrophages (4...
September 17, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27633774/novel-insights-into-vascularization-patterns-and-angiogenic-factors-in-glioblastoma-subclasses
#17
Siobhan Conroy, Michiel Wagemakers, Annemiek M E Walenkamp, Frank A E Kruyt, Wilfred F A den Dunnen
Glioblastoma (GBM) is a highly vascularized and aggressive type of primary brain tumor in adults with dismal survival. Molecular subtypes of GBM have been identified that are related to clinical outcome and response to therapy. Although the mesenchymal type has been ascribed higher angiogenic activity, extensive characterization of the vascular component in GBM subtypes has not been performed. Therefore, we aimed to investigate the differential vascular status and angiogenic signaling levels in molecular subtypes...
September 15, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27626602/carpolobia-lutea-g-don-polygalaceae-inhibits-inflammation-and-oxidative-stress-in-an-acetic-acid-induced-model-of-rat-colitis
#18
O O Abiodun, A O Oshinloye
Carpolobia lutea G. Don (CL) is used in folk medicine for the treatment of inflammatory disorders. Effort in this study is to evaluate the beneficial effect of the aqueous-methanol extract of leaf of CL in a rat model of acetic acid induced colitis. Male Wistar rats were distributed into 6 groups of 7 rats each; non colitic, untreated colitic and colitic rats treated with graded doses of CL (100-800 mg/kg). Rats were pre-treated for 2 days before colitis induction and thereafter for 7 days post colitic induction...
September 14, 2016: Drug Research
https://www.readbyqxmd.com/read/27616656/caspase-inhibition-prevents-tumor-necrosis-factor-%C3%AE-induced-apoptosis-and-promotes-necrotic-cell-death-in-mouse-hepatocytes-in%C3%A2-vivo-and-in%C3%A2-vitro
#19
Hong-Min Ni, Mitchell R McGill, Xiaojuan Chao, Benjamin L Woolbright, Hartmut Jaeschke, Wen-Xing Ding
How different cell death modes and cell survival pathways cross talk remains elusive. We determined the interrelation of apoptosis, necrosis, and autophagy in tumor necrosis factor (TNF)-α/actinomycin D (ActD) and lipopolysaccharide/D-galactosamine (GalN)-induced hepatotoxicity in vitro and in vivo. We found that TNF-α/ActD-induced apoptosis was completely blocked by a general caspase inhibitor ZVAD-fmk at 24 hours but hepatocytes still died by necrosis at 48 hours. Inhibition of caspases also protected mice against lipopolysaccharide/GalN-induced apoptosis and liver injury at the early time point, but this protection was diminished after prolonged treatment by switching apoptosis to necrosis...
October 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27588096/non-intervention-observation-dynamic-evolution-laws-of-inflammatory-response-in-necrotizing-enterocolitis
#20
Wei Wang, Li Xue, Tongsheng Ma, Yuan Li, Zhenguang Li
The pathogenesis of necrotizing enterocolitis (NEC) is not well understood but immunological factors are thought to be key determinants of the disease appearance and its prognosis. During the course of the present study, different groups of newborn infants were observed and tested, to obtain an accurate image of values of pro- and anti-inflammatory cytokines at the onset, development and progression of neonatal NEC and to compare the values to those obtained during normal healthy development. All the infants in the study received standard medical treatment as appropriate...
September 2016: Experimental and Therapeutic Medicine
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