Anna Lena Fisse, Emelie Schäfer, Alina Hieke, Maximilian Schröder, Rafael Klimas, Jil Brünger, Sophie Huckemann, Thomas Grüter, Melissa Sgodzai, Christiane Schneider-Gold, Ralf Gold, Huu Phuc Nguyen, Kalliopi Pitarokoili, Jeremias Motte, Larissa Arning
BACKGROUND AND PURPOSE: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease with humoral and cellular autoimmunity causing demyelination of peripheral nerves, commonly treated with intravenous immunoglobulins (IVIg). The neonatal Fc receptor (FcRn), encoded by the FCGRT gene, prevents the degradation of immunoglobulin G (IgG) by recycling circulating IgG. A variable number of tandem repeat (VNTR) polymorphism in the promoter region of the FCGRT gene is associated with different expression levels of mRNA and protein...
January 11, 2024: European Journal of Neurology