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https://www.readbyqxmd.com/read/28081189/global-gene-expression-analysis-of-cross-protected-phenotype-of-pectobacterium-atrosepticum
#1
Vladimir Gorshkov, Stanford Kwenda, Olga Petrova, Elena Osipova, Yuri Gogolev, Lucy N Moleleki
The ability to adapt to adverse conditions permits many bacterial species to be virtually ubiquitous and survive in a variety of ecological niches. This ability is of particular importance for many plant pathogenic bacteria that should be able to exist, except for their host plants, in different environments e.g. soil, water, insect-vectors etc. Under some of these conditions, bacteria encounter absence of nutrients and persist, acquiring new properties related to resistance to a variety of stress factors (cross-protection)...
2017: PloS One
https://www.readbyqxmd.com/read/28075338/maternal-exposure-to-pyrethroid-insecticides-during-pregnancy-and-infant-development-at-18-months-of-age
#2
Aya Hisada, Jun Yoshinaga, Jie Zhang, Takahiko Kato, Hiroaki Shiraishi, Kazuhisa Shimodaira, Takashi Okai, Nagako Ariki, Yoko Komine, Miyako Shirakawa, Yumiko Noda, Nobumasa Kato
The possible association between maternal exposure to pyrethroid insecticides (PYRs) during pregnancy and infant development was explored. Levels of exposure to PYRs was assessed by metabolite (3-phenoybenzoic acid, 3-PBA) concentration in maternal spot urine sampled in the first trimester of index pregnancy, and infant development was assessed at 18 months of age using the Kinder Infants Development Scale (KIDS), which is based on a questionnaire to the caretaker. The relationship between KIDS score and maternal urinary 3-PBA levels was examined by a stepwise multiple regression analysis using biological attributes of the mother and infant, breast feeding, and nursing environment as covariates...
January 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28071889/enzyme-and-redox-dual-triggered-intracellular-release-from-actively-targeted-polymeric-micelles
#3
Lei Zhang, Yi Wang, Xiaobin Zhang, Xiao Wei, Xiang Xiong, Shaobing Zhou
Highly effective delivery of therapeutic agents into target cells using nanocarriers and subsequently rapid intracellular release are of great importance in cancer treatment. Here, we developed an enzyme and redox dual-responsive polymeric micelle with active targeting abilities to achieve rapid intracellular drug release. To overcome both its poor solubility in water and instability in the blood circulation, camptothecin (CPT) was chemically conjugated to monomethyl poly(ethylene glycol) (mPEG) via a redox-responsive linker to form polymeric prodrugs...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28070588/a-silica-based-sers-chip-for-rapid-and-ultrasensitive-detection-of-fluoride-ions-triggered-by-a-cyclic-boronate-ester-cleavage-reaction
#4
Jian Zhang, Lifang He, Peirong Chen, Chao Tian, Jianping Wang, Bianhua Liu, Changlong Jiang, Zhongping Zhang
Chemical sensing for the convenient detection of trace aqueous fluoride ions (F(-)) has been widely explored with the use of various sensing materials and techniques. It still remains a challenge to achieve ultrasensitive but simple, rapid, and inexpensive detection of F(-) for environmental monitoring and protection. Here we reported a novel surface-enhanced Raman scattering (SERS) nanosensor, fluorescein phenylboronic acid covalently linked to 1,4-dimercapto-2,3-butanediol modified Au@Ag NPs by a cyclic boronate ester (Flu-PBA-Diol-Au@Ag NPs), for the rapid and ultrasensitive detection of F(-)...
January 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28069662/endoplasmic-reticulum-stress-inhibition-limits-the-progression-of-chronic-kidney-disease-in-the-dahl-salt-sensitive-rat
#5
Victoria Yum, Rachel E Carlisle, Chao Lu, Elise Brimble, Jasmine Chahal, Chandak Upagupta, Kjetil Ask, Jeffrey G Dickhout
Proteinuria is one of the primary risk factors for the progression of chronic kidney disease (CKD) and has been implicated in the induction of endoplasmic reticulum (ER) stress. We hypothesized that the suppression of ER stress with a low molecular weight chemical chaperone, 4-phenylbutyric acid (4-PBA), would reduce the severity of CKD and proteinuria in the Dahl salt-sensitive (SS) hypertensive rat. To induce hypertension and CKD, 12-wk-old male rats were placed on a high-salt (HS) diet for 4 wk with or without 4-PBA treatment...
January 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28064506/simultaneous-analysis-of-3-mcpd-and-1-3-dcp-in-asian-style-sauces-using-quechers-extraction-and-gas-chromatography-triple-quadrupole-mass-spectrometry
#6
Susan Genualdi, Patricia Jean Nyman, Lowri S deJager
Acid hydrolyzed vegetable protein (aHVP) is used for flavoring a wide variety of foods and also in the production of non-fermented soy sauce. During the production of aHVP, chloropropanols including 3-monochloropropane-1,2-diol (3-MCPD) and 1,3 dichloropropane-2-ol (1,3-DCP) can be formed through the reaction of the hydrochloric acid catalyst and residual fat and the reaction of 3-MCPD with acetic acid, respectively. 3-MCPD is a carcinogen and 1,3-DCP has been classified as a genotoxic carcinogen. The European Union (EU) has set a maximum concentration of 0...
January 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28063906/pyrazinamide-induced-hepatotoxicity-is-alleviated-by-4-pba-via-inhibition-of-the-perk-eif2%C3%AE-atf4-chop-pathway
#7
Hong-Li Guo, Hozeifa M Hassan, Ping-Ping Ding, Shao-Jie Wang, Xi Chen, Tao Wang, Li-Xin Sun, Lu-Yong Zhang, Zhen-Zhou Jiang
Pyrazinamide (PZA)-induced serious liver injury, but the exact mechanism of PZA-induces hepatotoxicity remains controversial. Endoplasmic reticulum (ER) stress-caused cell apoptosis plays a critical role in the development of drug-induced liver injury (DILI). However, the direct connection between PZA toxicity and ER stress is unknown. In this study, we describe the role of ER stress in PZA induced hepatotoxicity in vivo and in vitro. We found that PZA induces apoptosis in HepG2 cells, and causes liver damage in rats, characterized by increased serum ALT, AST and TBA levels...
January 4, 2017: Toxicology
https://www.readbyqxmd.com/read/28062198/plasma-from-pre-pubertal-obese-children-impairs-insulin-stimulated-nitric-oxide-no-bioavailability-in-endothelial-cells-role-of-er-stress
#8
Natalia Di Pietro, M Loredana Marcovecchio, Sara Di Silvestre, Tommaso de Giorgis, Vincenzo Giuseppe Pio Cordone, Paola Lanuti, Francesco Chiarelli, Giuseppina Bologna, Angelika Mohn, Assunta Pandolfi
Childhood obesity is commonly associated with early signs of endothelial dysfunction, characterized by impairment of insulin signaling and vascular Nitric Oxide (NO) availability. However, the underlying mechanisms remain to be established. Hence, we tested the hypothesis that endothelial insulin-stimulated NO production and availability was impaired and related to Endoplasmic Reticulum (ER) in human umbilical vein endothelial cells (HUVECs) cultured with plasma obtained from pre-pubertal obese (OB) children...
January 3, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28061749/organelle_pba-a-pipeline-for-assembling-chloroplast-and-mitochondrial-genomes-from-pacbio-dna-sequencing-data
#9
Aboozar Soorni, David Haak, David Zaitlin, Aureliano Bombarely
BACKGROUND: The development of long-read sequencing technologies, such as single-molecule real-time (SMRT) sequencing by PacBio, has produced a revolution in the sequencing of small genomes. Sequencing organelle genomes using PacBio long-read data is a cost effective, straightforward approach. Nevertheless, the availability of simple-to-use software to perform the assembly from raw reads is limited at present. RESULTS: We present Organelle-PBA, a Perl program designed specifically for the assembly of chloroplast and mitochondrial genomes...
January 7, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28058584/pyrethroid-insecticide-lambda-cyhalothrin-and-its-metabolites-induce-liver-injury-through-the-activation-of-oxidative-stress-and-proinflammatory-gene-expression-in-rats-following-acute-and-subchronic-exposure
#10
Bakhta Aouey, Mohamed Derbali, Yassine Chtourou, Michèle Bouchard, Abdelmajid Khabir, Hamadi Fetoui
Lambda-cyhalothrin (LTC) [α-cyano-3-phenoxybenzyl-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclo-propanecarboxylate] is a synthetic type II pyrethroid insecticide commonly used in residential and agricultural areas. The potential hepatotoxicity of pyrethroids remains unclear and could easily be assessed by measuring common clinical indicators of liver disease. To understand more about the potential risks for humans associated with LTC exposure, male adult rats were orally exposed to 6.2 and 31.1 mg/kg bw of LTC for 7, 30, 45, and 60 days...
January 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28042340/systemic-sirna-delivery-with-a-dual-ph-responsive-and-tumor-targeted-nanovector-for-inhibiting-tumor-growth-and-spontaneous-metastasis-in-orthotopic-murine-model-of-breast-carcinoma
#11
Bo Fan, Lin Kang, Liqing Chen, Ping Sun, Mingji Jin, Qiming Wang, You Han Bae, Wei Huang, Zhonggao Gao
Phenylboronic acid (PBA)-mediated tumor targeting nanovector is an attractive strategy for enhancing siRNA delivery and treatment of metastatic cancers. However, its nonspecific binding with various biological membranes containing cis-diol moieties restricts its potential application by systematic administration. Herein, we constructed a novel pH-activated "sheddable" PEG-coated nanoparticle for effective treatment of primary tumors and metastases, which was based on the conjugation of catechol group modified poly(ethylene glycol) (PEG-Cat) and PBA-terminated polyethylenimine (PEI-PBA) via the borate ester formed between PBA and Cat...
2017: Theranostics
https://www.readbyqxmd.com/read/28039491/sodium-fluoride-naf-induces-the-splenic-apoptosis-via-endoplasmic-reticulum-er-stress-pathway-in-vivo-and-in-vitro
#12
Huidan Deng, Ping Kuang, Hengmin Cui, Lian Chen, Qin Luo, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Ling Zhao
At present, there are no reports on the relationship between fluoride-induced apoptosis and endoplasmic reticulum (ER) stress (ER stress) in the spleen of human and animals in vivo and in vitro. Therefore, the aim of this study was to define sodium fluoride (NaF)-induced apoptosis mediated by ER stress in the spleen of mice in vivo and in vitro. Apoptosis and expression levels of the ER stress-related proteins were detected by flow cytometry and western blot, respectively. The results showed that NaF treatment increased lymphocytes apoptosis, which was consistent with NaF-caused ER Stress...
December 27, 2016: Aging
https://www.readbyqxmd.com/read/28036323/chemical-chaperone-4-phenylbutyric-acid-reduces-cardiac-ischemia-reperfusion-injury-by-alleviating-endoplasmic-reticulum-stress-and-oxidative-stress
#13
Lian Jian, Yuan Lu, Shan Lu, Chengzhi Lu
BACKGROUND Cardiovascular diseases are the leading cause of death in many countries and myocardial ischemia-reperfusion (I/R) injury is the cause of many serious heart diseases. Recent reports suggested that endoplasmic reticulum (ER) stress is associated with the progress of ischemia/reperfusion (I/R) injury. In a previous study, we illustrated that 4-phenylbutyric acid (4-PBA) reduces I/R-induced cell death in vitro through inhibiting the ER stress-initiated cell apoptosis. In the present study we investigated whether 4-PBA improves heart function in isolated rat hearts subjected to I/R and elucidated the potential mechanisms involved in 4-PBA-induced cardioprotective effects...
December 30, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28036165/scale-activity-relationship-of-mnox-feoy-nanocage-catalysts-derived-from-prussian-blue-analogues-for-low-temperature-no-reduction-experimental-and-dft-studies
#14
Lijun Yan, Yangyang Liu, Kaiwen Zha, Hongrui Li, Liyi Shi, Dengsong Zhang
Size effects have been recognized to promote the catalytic activity and selectivity of metal oxide particles. So far, limited works and studies are conducted to investigate the size effect of metal oxide with the tailored shape in the selective catalytic reduction of NOx with NH3 (NH3-SCR). Herein, the MnOx-FeOy nanocage catalysts with varied scales (0.25, 0.5, 1, and 2 μm) were synthesized via a Prussian blue analogue (PBA)-derived method and used for NH3-SCR of NO. By preforming a series of the activity tests over the nanocages with different scales, the NH3-SCR activity of 0...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28024567/sugar-sensitive-dendrimer-films-as-a-sacrificial-layer-for-the-preparation-of-freestanding-multilayer-films
#15
Fumiya Sato, Jun-Ichi Anzai
Multilayer thin films composed of poly(vinyl alcohol) (PVA) and phenylboronic acid-bearing poly(amidoamine) dendrimer (PBA-PAMAM) were used as a sacrificial layer for constructing freestanding polyelectrolyte films consisting of poly(styrenesulfonate) (PSS) and poly(allylamine hydrochloride) (PAH). Freestanding (PSS/PAH)15 films were successfully released from substrate by exposing composite (PVA/PBA-PAMAM)n/(PSS/PAH)15 films (n=5 and 10) to sorbitol solutions under mild conditions at pH7.0-9.0. The film release was accelerated in solutions of higher sorbitol concentrations at pH9...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28018864/mycobacterium-bovis-induces-endoplasmic-reticulum-stress-mediated-apoptosis-by-activating-irf3-in-a-murine-macrophage-cell-line
#16
Yongyong Cui, Deming Zhao, Srinand Sreevatsan, Chunfa Liu, Wei Yang, Zhiqi Song, Lifeng Yang, Paul Barrow, Xiangmei Zhou
Mycobacterium bovis (M. bovis) is highly adapted to macrophages and has developed multiple mechanisms to resist intracellular assaults. However, the host cells in turn deploy a multipronged defense mechanism to control bacterial infection. Endoplasmic reticulum (ER) stress-mediated apoptosis is one such primary defense mechanism. However, the role of interferon regulatory factor 3 (IRF3) between ER stress and apoptosis during M. bovis infection is unknown. Here, we demonstrate that M. bovis effectively induced apoptosis in murine macrophages...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28012960/heme-oxygenase-ho-1-induction-prevents-endoplasmic-reticulum-stress-mediated-endothelial-cell-death-and-impaired-angiogenic-capacity
#17
Hatem Maamoun, Matshediso Zachariah, John H McVey, Fiona R Green, Abdelali Agouni
Most of diabetic cardiovascular complications are attributed to endothelial dysfunction and impaired angiogenesis. Endoplasmic Reticulum (ER) and oxidative stresses were shown to play a pivotal role in the development of endothelial dysfunction in diabetes. Hemeoxygenase-1 (HO-1) was shown to protect against oxidative stress in diabetes; however, its role in alleviating ER stress-induced endothelial dysfunction remains not fully elucidated. We aim here to test the protective role of HO-1 against high glucose-mediated ER stress and endothelial dysfunction and understand the underlying mechanisms with special emphasis on oxidative stress, inflammation and cell death...
December 21, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28004067/-advanced-glycated-albumin-induces-macrophage-apoptosis-via-activating-caspase-12-pathway
#18
Jin-Guo Li, Qi Hao, Ying-Xue Liu, Peng Li, Peng Li, Xia-Yan Shao, Hua Tian, Yong-Qi Fang, Shu-Tong Yao
The purpose of the present study was to investigate the effect of advanced glycated albumin (AGE-alb) on the activation of caspase-12, a key molecule in endoplasmic reticulum stress (ERS)-associated apoptotic pathway, and to elucidate the underlying molecular mechanisms of macrophage apoptosis. RAW264.7 macrophages were treated with AGE-alb (2, 4 and 6 g/L), control albumin (C-alb, 4 g/L), tunicamycin (TM, 4 mg/L), or pretreated with 4-phenylbutyric acid (PBA, 5 mmol/L) for 1 h and then treated with AGE-alb (4 g/L)...
December 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/27998878/developing-an-unguided-internet-delivered-intervention-for-emotional-distress-in-primary-care-patients-applying-common-factor-and-person-based-approaches
#19
Adam Wa Geraghty, Ricardo F Muñoz, Lucy Yardley, Jennifer Mc Sharry, Paul Little, Michael Moore
BACKGROUND: Developing effective, unguided Internet interventions for mental health represents a challenge. Without structured human guidance, engagement with these interventions is often limited and the effectiveness reduced. If their effectiveness can be increased, they have great potential for broad, low-cost dissemination. Improving unguided Internet interventions for mental health requires a renewed focus on the proposed underlying mechanisms of symptom improvement and the involvement of target users from the outset...
December 20, 2016: JMIR Mental Health
https://www.readbyqxmd.com/read/27997281/use-of-compounded-dextromethorphan-quinidine-suspension-for-pseudobulbar-affect-in-hospice-patients
#20
Robert G Wahler, Alfred T Reiman, Joshua V Schrader
BACKGROUND: Pseudobulbar affect (PBA) consists of unprovoked and uncontrollable episodes of laughing and/or crying. In end-of-life situations, PBA symptoms can be especially distressing to family and friends during an already heightened emotional time. Although a commercial product combining dextromethorphan and quinidine (DMQ) is FDA approved for use in PBA, many hospice patients are unable to swallow any solids or semisolids. An alternative formulation for these patients is needed. OBJECTIVE: We present here two cases in which we used a compounded DMQ suspension successfully to treat PBA symptoms in the weeks before the patients' death...
December 20, 2016: Journal of Palliative Medicine
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