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https://www.readbyqxmd.com/read/29327364/4-phenylbutyric-acid-presents-therapeutic-effect-on-osteoarthritis-via-inhibiting-cell-apoptosis-and-inflammatory-response-induced-by-endoplasmic-reticulum-stress
#1
Yang-Hua Tang, Zhen-Shuang Yue, Wen-Jie Zheng, Hong-Fei Shen, Lin-Ru Zeng, Zhong-Qing Hu, Zhen-Fei Xiong
Osteoarthritis (OA) is a common bone and joint disease with a wild range of risk factors, which is associated with endoplasmic reticulum (ER) stress. The aim of our study was to discuss the possible mechanism of ER stress associated with OA in vivo and explore novel therapeutic method against OA. OA-induced damages in cartilage tissues were evaluated by HE, Safranin O/fast green and TUNEL staining. The inflammatory factors concentration and the expression of FAP, MMP2, MMP9, Bax, Bcl-2, CHOP and GRP78 were evaluated by ELISA, real-time PCR and western blot analysis...
January 11, 2018: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29310300/a-new-electrochemical-immunosensor-for-sensitive-detection-of-prion-based-on-prussian-blue-analogue
#2
Junjing Li, Xiaoxia Yan, Xiaoyu Li, Xiaohua Zhang, Jinhua Chen
Based on Co-Co Prussian blue analogue (Co-Co PBA), a novel immunosensor has been developed for sensitive detection of prion protein (PrPC). Gold nanoparticles (AuNPs)-modified Co-Co PBA nanocubes (PBA-AuNPs) worked as a support of the antibody (Ab2) of PrPC to obtain Ab2-PBA-AuNPs composite and also as the signal source for PrPC assay. When PrPC existed, Ab2-PBA-AuNPs could be introduced to the surface of another antibody of PrPC (Ab1) modified AuNPs/GC electrode (the gold nanoparticles-modified glassy carbon electrode) through specific antigen-antibody interaction between PrPC and its antibodies to form the Ab1-PrPC-Ab2 sandwich structure...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29301253/ros-mediated-cell-cycle-arrest-and-apoptosis-induced-by-zearalenone-in-mouse-sertoli-cells-via-er-stress-and-the-atp-ampk-pathway
#3
Wang-Long Zheng, Bing-Jie Wang, Ling Wang, Yu-Ping Shan, Hui Zou, Rui-Long Song, Tao Wang, Jian-Hong Gu, Yan Yuan, Xue-Zhong Liu, Guo-Qiang Zhu, Jian-Fa Bai, Zong-Ping Liu, Jian-Chun Bian
Zearalenone (ZEA) can perturb the differentiation of cells, reduce the generation of reproductive cells and induce a death of germ cells, but the molecular mechanism remains unclear. In order to investigate the potential mechanism of ZEA-induced cell cycle arrest and apoptosis, we studied the effects of ZEA on cell proliferation, cell-cycle distribution, cell-cycle-related proteins, cell death, cell apoptosis, ROS generation and the ATP/AMPK pathway in Sertoli cells. The role of ROS, ER stress and the ATP/AMPK pathway in ZEA-induced cell-cycle arrest and cell apoptosis was explored by using the antioxidant NAC, ER stress inhibitor 4-PBA and the AMPK inhibitor dorsomorphin, respectively...
January 1, 2018: Toxins
https://www.readbyqxmd.com/read/29297657/pharmacotherapeutic-management-of-pseudobulbar-affect
#4
Jack J Chen
This activity will update pharmacists and other healthcare professionals on current treatments for pseudobulbar affect (PBA). Points of discussion will focus on the off-label therapies traditionally used to treat PBA, the FDA-approved combination drug product with PBA as an indication, and managed care aspects of treating PBA.
December 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29297656/introduction-to-pseudobulbar-affect-setting-the-stage-for-recognition-and-familiarity-with-this-challenging-disorder
#5
Tammie Lee Demler
Pseudobulbar affect (PBA), despite its prevalence and distinctive symptoms, is widely underrecognized and undertreated. It is characterized by uncontrollable laughing or crying that can occur in an exaggerated manner or inappropriately to a given situation or stimuli. PBA is thought to center around preexisting neurological conditions, which include Parkinson disease, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer disease, traumatic brain injury, and stroke. The PBA Registry Series trial was created to measure the prevalence of PBA among patients with these underlying neurological conditions...
December 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29285080/orally-administered-sodium-4-phenylbutyrate-suppresses-the-development-of-dextran-sulfate-sodium-induced-colitis-in-mice
#6
Kazuhiko Ono, Satoshi Nimura, Yuko Hideshima, Kazuki Nabeshima, Manabu Nakashima
Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal administration of PBA suppresses the onset of dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, the effects of orally administered PBA are investigated, as this route of administration is more clinically relevant. The therapeutic efficacy of PBA (10 mg/12 h) in mice with experimental colitis was assessed based on the disease activity index, production of inflammatory cytokines, colon length and histopathological investigations...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29284785/dose-reconstruction-in-workers-exposed-to-two-major-pyrethroid-pesticides-and-determination-of-biological-reference-values-using-a-toxicokinetic-model
#7
Jonathan Côté, Michèle Bouchard
A toxicokinetic model has been optimized to describe the time profiles of common biomarkers of exposure to permethrin and cypermethrin: trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acids (trans-DCCA) and 3-phenoxybenzoic acid (3-PBA). The model then served to reproduce urinary time courses in exposed agricultural workers and predict corresponding absorbed doses. It allowed for the prediction of the main routes of exposure in workers during the study period. Modeling showed that simulating exposure mostly by the oral route, during the 3-day biomonitoring period, provided best-fits to the urinary time courses of most workers...
December 28, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29274948/associations-of-maternal-exposure-to-organophosphate-and-pyrethroid-insecticides-and-the-herbicide-2-4-d-with-birth-outcomes-and-anogenital-distance-at-3-months-in-the-odense-child-cohort
#8
Louise Dalsager, Lisa Elmer Christensen, Malene Gjelstrup Kongsholm, Henriette Boye Kyhl, Flemming Nielsen, Greet Schoeters, Tina Kold Jensen, Helle Raun Andersen
In Odense Child Cohort (OCC), concentrations of the pesticide metabolites 3-phenoxybenzoic acid (3-PBA), 3,5,6-trichloro-2-pyridinol (TCPY), 2,4-Dichlorophenoxyacetic acid (2,4-D) and dialkyl phosphates (DAPs) were measured in urine samples collected in gestational week 28 in up to 858 women. Gestational length, birth weight, head and abdominal circumference were obtained from birth records and anogenital distance (AGD) was measured at age three month. We did not find consistent dose-related associations between pesticide metabolite concentrations and birth outcomes or AGD...
December 21, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/29238517/exogenous-h2s-restores-ischemic-post-conditioning-induced-cardioprotection-through-inhibiting-endoplasmic-reticulum-stress-in-the-aged-cardiomyocytes
#9
Weiming Sun, Jinxia Yang, Yuanzhou Zhang, Yuxin Xi, Xin Wen, Di Yuan, Yuehong Wang, Can Wei, Rui Wang, Lingyun Wu, Hongzhu Li, Changqing Xu
Background: A gasotransmitter hydrogen sulfide (H2S) plays an important physiological and pathological role in cardiovascular system. Ischemic post-conditioning (PC) provides cardioprotection in the young hearts but not in the aged hearts. Exogenous H2S restores PC-induced cardioprotection by inhibition of mitochondrial permeability transition pore opening and oxidative stress and increase of autophagy in the aged hearts. However, whether H2S contributes to the recovery of PC-induced cardioprotection via down-regulation of endoplasmic reticulum stress (ERS) in the aged hearts is unclear...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29235576/the-unfolded-protein-response-impacts-melanoma-progression-by-enhancing-fgf-expression-and-can-be-antagonized-by-a-chemical-chaperone
#10
Karin Eigner, Yüksel Filik, Florian Mark, Birgit Schütz, Günter Klambauer, Richard Moriggl, Markus Hengstschläger, Herbert Stangl, Mario Mikula, Clemens Röhrl
The mechanisms hallmarking melanoma progression are insufficiently understood. Here we studied the impact of the unfolded protein response (UPR) - a signalling cascade playing ambiguous roles in carcinogenesis - in melanoma malignancy. We identified isogenic patient-derived melanoma cell lines harboring BRAFV600E-mutations as a model system to study the role of intrinsic UPR in melanoma progression. We show that the activity of the three effector pathways of the UPR (ATF6, PERK and IRE1) was increased in metastatic compared to non-metastatic cells...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233376/a-pharmacy-student-s-role-as-a-teaching-assistant-in-an-undergraduate-medicinal-chemistry-course-implementation-evaluation-and-unexpected-opportunities-for-educational-outreach
#11
Matthew J DellaVecchia, Alyssa M Claudio, Jamie L Fairclough
BACKGROUND AND PURPOSE: To describe 1) a pharmacy student's teaching assistant (TA) role in an undergraduate medicinal chemistry course, 2) an active learning module co-developed by the TA and instructor, and 3) the unexpected opportunities for pharmacy educational outreach that resulted from this collaboration. EDUCATIONAL ACTIVITY AND SETTING: Medicinal Chemistry (CHM3413) is an undergraduate course offered each fall at Palm Beach Atlantic University (PBA). As a TA for CHM3413, a pharmacy student from the Gregory School of Pharmacy (GSOP) at PBA co-developed and implemented an active learning module emphasizing foundational medicinal chemistry concepts as they pertain to performance enhancing drugs (PEDs)...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233306/integration-and-assessment-of-the-situation-background-assessment-recommendation-framework-into-a-pharmacotherapy-skills-laboratory-for-interprofessional-communication-and-documentation
#12
Susanne Barnett, Michael W Nagy, Robert C Hakim
BACKGROUND AND PURPOSE: The situation-background-assessment-recommendation (SBAR) framework is a commonly used method to structure verbal communication in the nursing and medicine disciplines and increases the effectiveness of interprofessional communication. The purpose of this manuscript is to describe how the SBAR framework is integrated into a pharmacotherapy skills laboratory for interprofessional communication and to report on student agreement of perceived realism, preparedness, and fairness of assessment relating to simulated SBAR activities...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29225223/ph-independent-recognition-of-polyhydroxy-compounds-by-niobium-v-porphyrin-complex-with-unique-sugar-selectivity
#13
Takuya Doi, Norihide Kachikawa, Takashi Yasui, Akio Yuchi
The niobium(V) complex with tetraphenylporphin having OH- as an auxilliay ligand exists as a dimeric complex, [Nb2(tpp)2O3] at a total concentration >10-4.5 mol dm-3, and reacts with an aliphatic or aromatic polyhydroxy compound to form a monomeric complex containing chelate rings by coordination of the deprotonated species, and to cause an appreciable UV-Vis spectral change. In contrast to phenylboronic acid (PBA), the reactivity of [Nb2(tpp)2O3] is independent of pH at least between 4 and 8. Aliphatic comounds are more reactive than aromatic compounds in dioxane-water, while the reactivity order is reversed in the two-phase reaction...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29215972/accuracy-of-smartphone-based-pulse-oximetry-compared-with-hospital-grade-pulse-oximetry-in-healthy-children
#14
Sarah Tomlinson, Sydney Behrmann, James Cranford, Marisa Louie, Andrew Hashikawa
BACKGROUND: Pulse oximetry, a ubiquitous, noninvasive method to monitor oxygen saturation (SpO2), requires larger, nonportable equipment. Smartphone pulse oximeter applications (apps) provide a portable, cost-effective option, but are untested in children. We hypothesize that smartphone pulse oximetry will not be inferior to standard pulse oximetry measured in healthy children. MATERIALS AND METHODS: Two main types of pulse oximetry apps, a camera-based app (CBA) that uses a phone camera flash and lens and a probe-based app (PBA) that uses an external plug-in probe, were compared with standard pulse oximetry measured in children ages 2-13 years without a respiratory complaint and a triage SpO2 ≥97% seen in a pediatric Emergency Department...
December 7, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29208463/stellate-ganglion-block-ameliorates-vascular-calcification-by-inhibiting-endoplasmic-reticulum-stress
#15
Wei Hao, Rui Yang, Yang Yang, Sheng Jin, Yanqing Li, Fang Yuan, Qi Guo, Lin Xiao, Xin Wang, Fuwei Wang, Yuming Wu, Xu Teng
AIMS: Vascular calcification (VC) underlies substantial cardiovascular morbidity and mortality. No clinically therapies have emerged presently. Stellate ganglion block (SGB) is one of the most often used sympathetic blockade procedure, and regulates vascular dilation. However, the effect of SGB on VC is still unknown. Therefore, we aimed to identify the ameliorative effect of SGB on VC. KEY FINDING: In vivo VC was induced in rats by administering vitamin D3 plus nicotine (VDN), and in vitro calcification of rat aortic vascular smooth muscle cells (VSMC) was induced by β-glycerophosphate...
December 2, 2017: Life Sciences
https://www.readbyqxmd.com/read/29208022/role-of-endoplasmic-reticulum-stress-in-the-protective-effects-of-ppar%C3%AE-%C3%AE-activation-on-endothelial-dysfunction-induced-by-plasma-from-patients%C3%A2-with-lupus
#16
Marta Toral, Rosario Jiménez, Miguel Romero, Iñaki Robles-Vera, Manuel Sánchez, Mercedes Salaices, José Mario Sabio, Juan Duarte
BACKGROUND: We tested whether GW0742, a peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) agonist, improves endothelial dysfunction induced by plasma from patients with systemic lupus erythematosus (SLE) involving the inhibition of endoplasmic reticulum (ER) stress. METHODS: A total of 12 non-pregnant women with lupus and 5 non-pregnant healthy women (controls) participated in the study. Cytokines and double-stranded DNA autoantibodies (anti-dsDNA) were tested in plasma samples...
December 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29206294/hormone-regulates-endometrial-function-via-cooperation-of-endoplasmic-reticulum-stress-and-mtor-autophagy
#17
Diqi Yang, Tingting Jiang, Jianguo Liu, Jin Hong, Pengfei Lin, Huatao Chen, Dong Zhou, Keqiong Tang, Aihua Wang, Yaping Jin
In ruminant, the receptive endometrium and the elongation of the hatched blastocyst are required to complete the process of implantation. However, the mechanisms regulating goat endometrial function during the peri-implantation period of pregnancy are still unclear. In this study, EECs were treated with progesterone, estradiol and interferon-tau (IFNT). We have found that endoplasmic reticulum (ER) stress were activated under hormones treatment. To identify the cellular mechanism of regulation of endometrial function, we investigated the effect of ER stress activator thapsigargin (TG) and inhibitor 4 phenyl butyric acid (4-PBA) on EECs...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29193611/effect-of-the-cross-talk-between-autophagy-and-endoplasmic-reticulum-stress-on-mn-induced-alpha-synuclein-oligomerization
#18
Chang Liu, Dong-Ying Yan, Xuan Tan, Zhuo Ma, Can Wang, Yu Deng, Wei Liu, Tian-Yao Yang, Zhao-Fa Xu, Bin Xu
Overexposure to manganese (Mn) has been known to induce alpha-synuclein (α-Syn) oligomerization, which is degraded mainly depending on endoplasmic reticulum stress (ER stress) and autophagy pathways. However, little data reported the cross-talk between ER stress and autophagy on Mn-induced α-Syn oligomerization. To explore the relationship between ER stress and autophagy, we used 4-phenylbutyric acid (4-PBA, the ER stress inhibitor), rapamycin (Rap, autophagy activator) and 3-methyladenine (3-MA, autophagy inhibitor) in mice model of manganism...
November 29, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29189555/what-is-in-the-literature
#19
Mark B Bromberg
This edition of "What is in the Literature?" will focus on motor neuron disease (MND), including adult forms [amyotrophic lateral sclerosis (ALS), progressive muscular atrophy (PMA), primary lateral sclerosis (PLS), progressive bulbar palsy (PBA), and monomelic mononeuropathy (MMND)], and childhood forms [spinal muscle atrophy (SMA)].
December 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/29183043/benzo-e-pyrene-inhibits-endothelium-dependent-no-mediated-dilation-of-retinal-arterioles-via-superoxide-production-and-endoplasmic-reticulum-stress
#20
Takayuki Kamiya, Taiji Nagaoka, Tsuneaki Omae, Shinji Ono, Shinichi Otani, Akitoshi Yoshida
Purpose: To investigate whether benzo(e)pyrene (B(e)P), a toxicant in cigarette smoke, affects the endothelium-dependent nitric oxide (NO)-induced vasodilation of the retinal arterioles, and whether oxidative stress, distinct protein kinase signaling pathways, and endoplasmic reticulum (ER) stress are associated with the B(e)P-induced effect on the retinal arterioles. Methods: In this in vitro study, porcine retinal arterioles were isolated, cannulated, and pressurized without flow...
November 1, 2017: Investigative Ophthalmology & Visual Science
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