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https://www.readbyqxmd.com/read/28511402/bladder-adenocarcinoma-a-persisting-diagnostic-dilemma
#1
Geetha Vasudevan, Arijit Bishnu, Brij Mohan Kumar Singh, Deepak M Nayak, Pooja Jain
Primary urinary Bladder Adenocarcinoma (PBA) is an uncommon neoplasm and can cause diagnostic difficulties due to histologic similarities with adenocarcinomas of adjacent structures like Gastrointestinal Tract (GIT) and prostate, since involvement of the bladder by metastasis or direct spread can occur. Seven cases of bladder adenocarcinomas were diagnosed during a period of four years in a tertiary care hospital. Patient's age ranged from 26-78 years with a male predilection. Three cases were signet ring type adenocarcinomas, two cases were subtyped as enteric variant, one as mucinous variant and one as adenocarcinoma Not Otherwise Specified (NOS) variant...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28501319/association-of-pyrethroids-exposure-with-onset-of-puberty-in-chinese-girls
#2
Xiaoqing Ye, Wuye Pan, Yuehao Zhao, Shilin Zhao, Yimin Zhu, Weiping Liu, Jing Liu
Pyrethroids, a class of ubiquitous insecticides, have been considered as endocrine-disrupting chemicals (EDCs). Female animal studies suggested that early-life pyrethroids exposure might delay puberty onset. However, it remains unclear whether this association applies to human populations. A total of 305 girls at the ages of 9-15 years old were recruited in Hangzhou, China in this study. The concentration of the common metabolite of pyrethroids, 3-phenoxybenzoic acid (3-PBA), was analyzed in urine samples to reflect the exposure level of pyrethroids...
May 10, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28500961/influence-of-polyethylene-glycol-on-the-phase-transition-of-poly-butylene-adipate-thin-films-polymorphic-control
#3
Yujing Chen, Isao Noda, Young Mee Jung
Control of the polymorphic crystals formation of poly(butylene adipate) (PBA) is crucial to tailor its performance. In the present study, we investigated the effect of polyethylene glycol (PEG) with molecular weight of 400 on the polymorphic crystal of PBA thin films using x-ray diffraction (XRD), temperature-dependent infrared-reflection absorbance spectroscopy (IRRAS) and two-dimensional correlation analysis (2DCOS). XRD and IRRAS results suggest that the PBA thin film tends to grow α-form crystal with addition of PEG at room temperature...
May 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28500249/maternal-high-fat-diet-induces-metabolic-stress-response-disorders-in-offspring-hypothalamus
#4
Long The Nguyen, Sonia Saad, Yi Tan, Carol Pollock, Hui Chen
Maternal obesity has been shown to increase the risk of obesity and related disorders in the offspring, which has been partially attributed to changes of appetite regulators in the offspring hypothalamus. On the other hand, endoplasmic reticulum (ER) stress and autophagy have been implicated in hypothalamic neuropeptide dysregulation, thus may also play important roles in such transgenerational effect.  In this study, we show that offspring born to HFD-fed dams showed significantly increased body weight and glucose intolerance, adiposity and plasma triglyceride level at weaning...
May 12, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28495084/structural-insight-into-the-active-site-of-mushroom-tyrosinase-using-phenylbenzoic-acid-derivatives
#5
Takahiro Oyama, Atsushi Yoshimori, Satoshi Takahashi, Tetsuya Yamamoto, Akira Sato, Takanori Kamiya, Hideaki Abe, Takehiko Abe, Sei-Ichi Tanuma
So far, many inhibitors of tyrosinase have been discovered for cosmetic and clinical agents. However, the molecular mechanisms underlying the inhibition in the active site of tyrosinase have not been well understood. To explore this problem, we examined here the inhibitory effects of 4'-hydroxylation and methoxylation of phenylbenzoic acid (PBA) isomers, which have a unique scaffold to inhibit mushroom tyrosinase. The inhibitory effect of 3-PBA, which has the most potent inhibitory activity among the isomers, was slightly decreased by 4'-hydroxylation and further decreased by 4'-methoxylation against mushroom tyrosinase...
April 26, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28488455/intracellular-methylglyoxal-induces-oxidative-damage-to-pancreatic-beta-cell-line-ins-1-cell-through-ire1%C3%AE-jnk-and-mitochondrial-apoptotic-pathway
#6
Chongxiao Liu, Yanhong Huang, Yifan Zhang, Xueru Chen, Xiang Kong, Yan Dong
An increased intracellular methylglyoxal (MGO) under hyperglycemia led to pancreatic beta cell death. However, its mechanism in which way with MGO induced beta cell death remains unknown. We investigated both high glucose and MGO treatment significantly inclined intracellular MGO concentration and inhibited cell viability in vitro. MGO treatment also triggered intracellular advanced glycation end products (AGEs) formation, declined mitochondrial membrane potential (MMP), increased oxidative stress and the expression of ER stress mediators Grp78/Bip and p-PERK; activated mitochondrial apoptotic pathway, which could mimic by Glo1 knockdown...
May 10, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28484809/novel-fast-analytical-method-for-indirect-determination-of-mcpd-fatty-acid-esters-in-edible-oils-and-fats-based-on-simultaneous-extraction-and-derivatization
#7
Renata Jędrkiewicz, Agnieszka Głowacz-Różyńska, Justyna Gromadzka, Piotr Konieczka, Jacek Namieśnik
A novel method for indirect determination of MCPD esters levels in lipid samples has been developed. The method is based on combination of extraction and derivatization in the same sample preparation step. It is achieved by the application of diethyl ether as extraction solvent for isolation of analytes released from esterified forms from the water phase and as dilution solvent for solid PBA - the derivatization agent. It is a noteworthy improvement of recommended indirect approaches available in the literature because such steps as sample clean-up, multiple liquid-liquid extractions, and preconcentration are excluded in the proposed solution...
May 8, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28483437/4-phenyl-butyric-acid-increases-particulate-hexokinase-activity-and-protects-against-ros-injury-in-l6-myotubes
#8
Michele Hinerasky da Silva, Flavia Letícia Martins Peçanha, Aline Machado de Oliveira, Wagner Seixas da-Silva
Hexokinase (HK) is the first enzyme in the glycolytic pathway and is responsible for glucose phosphorylation and fixation into the cell. HK (HK-II) is expressed in skeletal muscle and can be found in the cytosol or bound mitochondria, where it can protect cells against insults such as oxidative stress. 4-Phenyl butyric acid (4-PBA) is a chemical chaperone that inhibits endoplasmic reticulum stress and contributes to the restoring of glucose homeostasis. AIMS: Here, we decided to investigate whether HK activity and its interaction with mitochondria could be a target of 4-PBA action...
May 5, 2017: Life Sciences
https://www.readbyqxmd.com/read/28478668/relationships-of-pyrethroids-exposure-with-gonadotropins-levels-and-pubertal-development-in-chinese-boys
#9
Xiaoqing Ye, Wuye Pan, Shilin Zhao, Yuehao Zhao, Yimin Zhu, Jing Liu, Weiping Liu
Although an acceleration of male pubertal development has been observed, precisely which endocrine-disrupting chemicals (EDCs) might contribute to the advancing onset of puberty in boys remains unclear. Here, pyrethroids, a class of widely used insecticides that have been as considered as EDCs, are proposed as new environmental risk factors. In this study, 463 boys at the age of 9-16 years old were recruited in Hangzhou, Zhejiang, China. The common metabolites of pyrethroids, 3-phenoxybenzoic acid (3-PBA) and 4-fluro-3-phenoxybenzoic acid (4-F-3-PBA), as well as the gonadotropins, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH), were analyzed in urine samples...
May 8, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28470097/phenylbutyrate-and-%C3%AE-cell-function-contribution-of-histone-deacetylases-and-er-stress-inhibition
#10
Sabbir Khan, Sandeep K Komarya, Gopabandhu Jena
Incidences of diabetes are increasing globally due to involvement of genetic and epigenetic factors. Phenylbutyrate (PBA) is a US FDA approved drug for treatment of urea cycle disorder in children. PBA reduces endoplasmic reticulum (ER) stress and is proven as a potent histone deacetylases (HDACs) inhibitor. Chronic ER stress results in unfolding protein response, which triggers apoptosis. Abnormal ER homoeostasis is responsible for defective processing of several genes/proteins and contributes to β-cell death/failure...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28465244/perk-eif2%C3%AE-contributes-to-changes-of-insulin-signaling-in-hepg2-cell-induced-by-intermittent-hypoxia
#11
Huahua Yi, Chenjuan Gu, Min Li, Zhiguo Zhang, Qingyun Li, Jing Feng, Jun Zhou, Juan Du
AIMS: Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with abnormal glucose metabolism. Nowadays, endoplasmic reticulum (ER) stress emerges as an important mechanism underlying the development of type 2 diabetes mellitus (T2DM). However, it remains unclear that intermittent hypoxia (IH) could induce ER stress, resulting in abnormality of glucose metabolism. Thu, in the current study we explore the changes of insulin signaling under IH and the role of ER stress underlying these changes...
April 29, 2017: Life Sciences
https://www.readbyqxmd.com/read/28454880/expression-of-negative-immune-regulatory-molecules-pro-inflammatory-chemokine-and-cytokines-in-immunopathology-of-ecm-developing-mice
#12
Ashwin V Khandare, Deepali Bobade, Mangesh Deval, Tushar Patil, Bhaskar Saha, D Prakash
The pathological events in human cerebral malaria are mimicked in the experimental cerebral malaria (ECM) in Plasmodium berghei ANKA (PBA)-infected C57BL/6 mice. Although previously implied in ECM, the kinetics of cytokines and chemokines expression-an essential functional feature for defining causality in ECM development-remained untested. Herein, we characterized the immunopathological changes and the expression of negative immune regulatory molecules, cytokines and chemokines through asymptomatic (3days after infection, 3dpi), symptomatic (5dpi) and ECM (7dpi) stages in PBA-infected C57BL/6 mice...
April 25, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28453973/determinants-of-children-s-exposure-to-pyrethroid-insecticides-in-western-france
#13
Philippe Glorennec, Tania Serrano, Morgane Fravallo, Charline Warembourg, Christine Monfort, Sylvaine Cordier, Jean-François Viel, Florent Le Gléau, Barbara Le Bot, Cécile Chevrier
Pyrethroids are insecticides frequently used in agriculture and in the home; exposure occurs through dietary and non-dietary pathways, including indoor and outdoor environmental contamination. Our objective was to study the potential determinants of pyrethroid metabolite concentrations measured in children's urine samples and in the dust of their homes. Specifically, we measured urinary metabolites from morning spot samples of 245 six-year-old children living in Brittany (France) in 2009-2012 and from dust vacuumed from the floor of their homes...
April 25, 2017: Environment International
https://www.readbyqxmd.com/read/28451115/stretchable-supramolecular-hydrogels-with-triple-shape-memory-effect
#14
Xiaoxia Le, Wei Lu, Jing Zheng, Dingyi Tong, Ning Zhao, Chunxin Ma, He Xiao, Jiawei Zhang, Youju Huang, Tao Chen
Shape memory polymers based on reversible supramolecular interactions have invoked growing research interest, but still suffer from limitations such as poor mechanical strength and finite shape memory performance. Here, we present a novel mechanical stretchable supramolecular hydrogel with a triple shape memory effect at the macro/micro scale. The introduction of a double network concept into supramolecular shape memory hydrogels endows them with excellent mechanical properties. The design of two non-interfering supramolecular interaction systems of both dynamic phenylboronic (PBA)-diol ester bonds and the chelation of alginate with Ca(2+) endues the hydrogel with outstanding triple shape memory functionalities...
November 1, 2016: Chemical Science
https://www.readbyqxmd.com/read/28448579/il-33-receptor-st2-regulates-the-cognitive-impairments-associated-with-experimental-cerebral-malaria
#15
Flora Reverchon, Stéphane Mortaud, Maëliss Sivoyon, Isabelle Maillet, Anthony Laugeray, Jennifer Palomo, Céline Montécot, Améziane Herzine, Sandra Meme, William Meme, François Erard, Bernhard Ryffel, Arnaud Menuet, Valérie F J Quesniaux
Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors. The murine model of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA)-infection reproduces several of these features. We reported recently increased levels of IL-33 protein in brain undergoing ECM and the involvement of IL-33/ST2 pathway in ECM development. Here we show that PbA-infection induced early short term and spatial memory defects, prior to blood brain barrier (BBB) disruption, in wild-type mice, while ST2-deficient mice did not develop cognitive defects...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28444766/endoplasmic-reticulum-stress-mediates-distinct-impacts-of-sevoflurane-on-different-subfields-of-immature-hippocampus
#16
Gang Zhu, Lei Tao, Ronglin Wang, Ying Xue, Xingqin Wang, Shaosong Yang, Xude Sun, Guodong Gao, Zixu Mao, Qian Yang
Sevoflurane, a typical inhaled anesthetic, is widely used in patients of all ages during surgery. The negative effects, such as inducing cell death and damaging spatial memory, of sevoflurane on neurodevelopment have raised increasing concerns in recent years. However, the molecular mechanism remains unclear. The current study focused on the crucial role of endoplasmic reticulum (ER) stress in sevoflurane-induced hippocampal injury. Three-week-old rats were exposed to sevoflurane or control air for 5h with or without ER stress inhibitor (4-phenylbutyric acid, 4-PBA) injection...
April 26, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28443783/risk-due-to-exposure-to-metallic-elements-in-a-birdshot-factory
#17
Piero Lovreglio, Giovanni De Filippis, Brizio Tamborrino, Ignazio Drago, Rossana Rotondi, Annamaria Gallone, Matteo Paganelli, Pietro Apostoli, Leonardo Soleo
The contribution of biological and environmental monitoring to the risk assessment of occupational exposure to lead (Pb), arsenic (As) and antimony (Sb) was studied in 18 workers at a birdshot factory (Exposed) and in 18 control workers (Controls), by the determination both of airborne Pb (PbA) and As (AsA) only in the exposed workers, and blood Pb (PbB), erythrocytic zinc protoporphyrin (ZPP), urinary Sb (SbU) and the urinary As species in exposed workers and controls. PbA (12-42 μg/m(3)) and AsA (1-4 μg/m(3)) were strongly correlated (r = 0...
April 26, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28418182/cyclometalated-iridium-iii-bipyridine-phenylboronic-acid-complexes-as-luminescent-probes-for-sialic-acids-and-bioimaging-reagents
#18
Hua-Wei Liu, Wendell Ho-Tin Law, Lawrence Cho-Cheung Lee, Jonathan Chun-Wai Lau, Kenneth Kam-Wing Lo
Sialic acids play important roles in mammalian development, cell-cell attachment, and signaling. Since cancer cells utilize their overexpressed sialylated antigens to propagate metastases, the development of probes for sialic acids is of high importance. Herein, we report three luminescent cyclometalated iridium(III) bipyridine complexes bearing a phenylboronic acid (PBA) moiety. Spectrophotometric titrations revealed that the PBA complexes displayed higher binding affinity to the most common sialic acid N-acetylneuraminic acid (Neu5Ac) compared with simple sugars that are commonly found on glycoproteins...
April 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28414203/self-assembled-nanocomplex-between-polymerized-phenylboronic-acid-and-doxorubicin-for-efficient-tumor-targeted-chemotherapy
#19
Junseok Lee, Jinhwan Kim, Yeong Mi Lee, Dongsik Park, Sooseok Im, Eun Ho Song, Hansoo Park, Won Jong Kim
Since the discovery that nano-scaled particulates can easily be incorporated into tumors via the enhanced permeability and retention (EPR) effect, such nanostructures have been exploited as therapeutic small molecule delivery systems. However, the convoluted synthetic process of conventional nanostructures has impeded their feasibility and reproducibility in clinical applications. Herein, we report an easily prepared formulation of self-assembled nanostructures for systemic delivery of the anti-cancer drug doxorubicin (DOX)...
April 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28408208/establishing-alighting-preferences-and-species-transmission-differences-for-pea-seed-borne-mosaic-virus-aphid-vectors
#20
B S Congdon, B A Coutts, M Renton, G R Flematti, R A C Jones
Pea seed-borne mosaic virus (PSbMV) infection causes a serious disease of field pea (Pisum sativum) crops worldwide. The PSbMV transmission efficiencies of five aphid species previously found landing in south-west Australian pea crops in which PSbMV was spreading were studied. With plants of susceptible pea cv. Kaspa, the transmission efficiencies of Aphis craccivora, Myzus persicae, Acyrthosiphon kondoi and Rhopalosiphum padi were 27%, 26%, 6% and 3%, respectively. Lipaphis erysimi did not transmit PSbMV in these experiments...
April 11, 2017: Virus Research
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