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https://www.readbyqxmd.com/read/29165056/citrinin-induces-apoptosis-in-human-hct116-colon-cancer-cells-through-endoplasmic-reticulum-stress
#1
Amal Salah, Chayma Bouaziz, Alexandre Prola, Julie Pires Da Silva, Hassen Bacha, Salwa Abid-Essefi, Christophe Lemaire
The mycotoxin citrinin (CTN) is a natural contaminant of various human foods that may produce serious adverse health problems. Several studies demonstrated that citrinin exerts cytotoxic and genotoxic effects in both in vivo and in vitro systems. However, the precise mechanisms of action (MOA), particularly in intestinal cells remain unclear. The aim of the present study was to examine the precise MOA of citrinin in vitro. Data demonstrated that CTN significantly decreased the number of viable human intestinal HCT116 cells and induced apoptotic events including (1) decrease in ΔѰm indicative of mitochondrial membrane permeabilization, (2) activation of caspase 3, (3) elevated production of reactive oxygen species (ROS) and (4) relative persistence of plasma membrane integrity...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29156286/phytotoxicity-of-pyrethroid-pesticides-and-its-metabolite-towards-cucumis-sativus
#2
I Bragança, Paulo C Lemos, Piedade Barros, Cristina Delerue-Matos, Valentina F Domingues
Pyrethroid pesticides residues have been frequently detected in soils and have been recognized to contribute to soil toxicity. The phytotoxic impact of pesticides was evaluated in Cucumis sativus (C. sativus) seeds. Percentage of seed germination, root elongation, shoot length and leaf length were considered as endpoints to assess the possible acute phytotoxicity of soil by the exposure to pyrethroid pesticides (cypermethrin, deltamethrin and cyhalothrin) and its metabolite phenoxybenzoic acid (3-PBA), in a concentration range between 50 and 500μgkg(-1)...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29150129/diagnostic-accuracy-of-4-intraoral-radiographic-techniques-for-misfit-detection-at-the-implant-abutment-joint
#3
Pollyana Darós, Vinícius Cavalcanti Carneiro, Amanda Pasolini Siqueira, Sergio Lins de-Azevedo-Vaz
STATEMENT OF PROBLEM: A misfit or gap at the implant-abutment joint (IAJ) requires detection as it may compromise the health of the peri-implant tissue. However, which radiographic technique provides the most orthogonal relationship between the central beam and the implant/image receptor is unclear. PURPOSE: The purpose of this in vitro study was to evaluate the diagnostic accuracy of 4 intraoral radiographic techniques on misfit detection at the IAJ. MATERIAL AND METHODS: Twenty implants were placed in polyamide jaws, and customized dental implant abutments with a metal collar were installed...
November 15, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29143785/waterborne-polyurethane-coatings-with-covalently-linked-black-dye-sudan-black-b
#4
Tao Wang, Wei Sun, Xingyuan Zhang, Haiyan Xu, Fei Xu
Colored waterborne polyurethanes have been widely used in paintings, leathers, textiles, and coatings. Here, a series of black waterborne polyurethanes (WPUs) with different ratios of black dye, Sudan Black B (SDB), were prepared by step-growth polymerization. WPU emulsions as obtained exhibit low particle sizes and remarkable storage stability at the same time. At different dye loadings, essential structural, statistical and thermal properties are characterized. FTIR (fourier transform infrared) spectra indicate that SDB is covalently linked into waterborne polyurethane chains...
October 28, 2017: Materials
https://www.readbyqxmd.com/read/29142990/the-chemical-chaperone-pba-reduces-er-stress-and-autophagy-and-increases-collagen-iv-%C3%AE-5-expression-in-cultured-fibroblasts-from-men-with-x-linked-alport-syndrome-and-missense-mutations
#5
Dongmao Wang, Mardhiah Mohammad, Yanyan Wang, Rachel Tan, Lydia S Murray, Sharon Ricardo, Hayat Dagher, Tom van Agtmael, Judy Savige
Introduction: X-linked Alport syndrome (OMIM 301050) is caused by COL4A5 missense variants in 40% of families. This study examined the effects of chemical chaperone treatment (sodium 4-phenylbutyrate) on fibroblast cell lines derived from men with missense mutations. Methods: Dermal fibroblast cultures were established from 2 affected men and 3 normals. Proliferation rates were examined, the collagen IV α5 chain localized with immunostaining, and levels of the intra- and extracellular chains quantitated with an in-house enzyme-linked immunosorbent assay...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29137257/kaempferol-induces-hepatocellular-carcinoma-cell-death-via-endoplasmic-reticulum-stress-chop-autophagy-signaling-pathway
#6
Haiqing Guo, Wei Lin, Xiangying Zhang, Xiaohui Zhang, Zhongjie Hu, Liying Li, Zhongping Duan, Jing Zhang, Feng Ren
Kaempferol is a flavonoid compound that has gained widespread attention due to its antitumor functions. However, the underlying mechanisms are still not clear. The present study investigated the effect of kaempferol on hepatocellular carcinoma and its underlying mechanisms. Kaempferol induced autophagy in a concentration- and time-dependent manner in HepG2 or Huh7 cells, which was evidenced by the significant increase of autophagy-related genes. Inhibition of autophagy pathway, through 3-methyladenine or Atg7 siRNA, strongly diminished kaempferol-induced apoptosis...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29125264/drug-coated-balloons-reduce-the-risk-of-recurrent-restenosis-in-arteriovenous-fistulas-and-prosthetic-grafts-for-hemodialysis
#7
Nicola Troisi, Pierfrancesco Frosini, Chiara Somma, Eugenio Romano, Azzurra Guidotti, Pietro C Dattolo, Giuseppe Ferro, Emiliano Chisci, Stefano Michelagnoli
BACKGROUND: Aim of this study was to evaluate the early and mid-term outcomes of drug-coated balloons (DCBs) in hemodialysis patients with recurrent stenosis of arteriovenous fistula and previously treated with plain balloon angioplasty (PBA). METHODS: Between July 2013 and June 2016 38 hemodialysis patients with recurrent stenosis of arteriovenous fistula underwent endovascular treatment with a DCB at our center. All patients were previously treated at the target lesion with a PBA...
November 10, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29113976/co-infection-with-chikungunya-virus-alters-trafficking-of-pathogenic-cd8-t-cells-into-the-brain-and-prevents-plasmodium-induced-neuropathology
#8
Teck-Hui Teo, Shanshan W Howland, Carla Claser, Sin Yee Gun, Chek Meng Poh, Wendy Wl Lee, Fok-Moon Lum, Lisa Fp Ng, Laurent Rénia
Arboviral diseases have risen significantly over the last 40 years, increasing the risk of co-infection with other endemic disease such as malaria. However, nothing is known about the impact arboviruses have on the host response toward heterologous pathogens during co-infection. Here, we investigate the effects of Chikungunya virus (CHIKV) co-infection on the susceptibility and severity of malaria infection. Using the Plasmodium berghei ANKA (PbA) experimental cerebral malaria (ECM) model, we show that concurrent co-infection induced the most prominent changes in ECM manifestation...
November 7, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29113940/screening-level-biomonitoring-equivalents-for-tiered-interpretation-of-urinary-3-phenoxybenzoic-acid-3-pba-in-a-risk-assessment-context
#9
Lesa L Aylward, Kim Irwin, Annie St-Amand, Andy Nong, Sean M Hays
3-Phenoxybenzoic acid (3-PBA) is a common metabolite of several pyrethroid pesticides of differing potency and also occurs as a residue in foods resulting from environmental degradation of parent pyrethroid compounds. Thus, 3-PBA in urine is not a specific biomarker of exposure to a particular pyrethroid. However, an approach derived from the use of Biomonitoring Equivalents (BEs) can be used to estimate a conservative initial screening value for a tiered assessment of population data on 3-PBA in urine. A conservative generic urinary excretion fraction for 3-PBA was estimated from data for five pyrethroid compounds with human data...
November 4, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29113605/rapid-review-of-cognitive-screening-instruments-in-mci-proposal-for-a-process-based-approach-modification-of-overlapping-tasks-in-select-widely-used-instruments
#10
Unai Díaz-Orueta, Alberto Blanco-Campal, Teresa Burke
BACKGROUND: A detailed neuropsychological assessment plays an important role in the diagnostic process of Mild Cognitive Impairment (MCI). However, available brief cognitive screening tests for this clinical population are administered and interpreted based mainly, or exclusively, on total achievement scores. This score-based approach can lead to erroneous clinical interpretations unless we also pay attention to the test taking behavior or to the type of errors committed during test performance...
November 8, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29108970/inducers-of-salmon-innate-immunity-an-in-vitro-and-in-vivo-approach
#11
Rosana A Estévez, Miriam G Contreras Mostazo, Eduardo Rodriguez, Juan Carlos Espinoza, Juan Kuznar, Zophonías O Jónsson, Guðmundur H Guðmundsson, Valerie H Maier
Maintaining fish health is one of the most important aims in aquaculture. Prevention of fish diseases therefore is crucial and can be achieved by various different strategies, including most often a combination of different methods such as optimal feed and fish density, as well as strengthening the immune system. Understanding the fish innate immune system and developing methods to activate it, in an effort to prevent infections in the first place, has been a goal in recent years. In this study we choose different inducers of the innate immune system and examined their effects in vitro on the salmon cell line CHSE-214...
November 8, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29105180/tuning-electronic-properties-of-prussian-blue-analogues-for-efficient-water-oxidation-electrocatalysis-experimental-and-computational-studies
#12
Elif Pınar Alsaç, Emine Ülker, Satya Vijaya Kumar Nune, Yavuz Dede, Ferdi Karadas
While several Prussian blue analogues (PBAs) have been investigated as water oxidation catalysts, the field lacks a comprehensive study that focuses on the design of the ideal PBA for efficient water oxidation catalysis. Herein, a series of PBAs with different cyanide precursors were investigated to study the effect of hexacyanometal group to their electrocatalytic water oxidation activities. Cyclic voltammetric, chronoamperometric, and chronopotentiometric measurements reveal the close relation between the electron density of electroactive cobalt sites and electrocatalytic activity, which is also confirmed by Infrared and XPS studies...
November 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29100417/inhibition-of-endoplasmic-reticulum-stress-alleviates-cigarette-smoke-induced-airway-inflammation-and-emphysema
#13
Yong Wang, Zhen-Zhen Wu, Wei Wang
Chronic bronchitis and emphysema are pathologic features of chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS)-induced endoplasmic reticulum (ER) stress has been implicated in the COPD development, but the molecular mechanism by which it contributes to COPD etiology and the specific role it plays in COPD pathogenesis remain poorly understood. Here, we aimed to determine the role of ER stress in the pathogenesis of CS-induced airway inflammation and emphysema. Exposure to CS significantly increased the expression of ER stress markers in Beas-2B cells and in mouse lungs, possibly through the production of oxidative stress...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29080681/uncoupling-of-er-mitochondrial-oxidative-stress-in-mtorc1-hyperactivation-associated-skin-hypopigmentation
#14
Fei Yang, Lingli Yang, Mari Wataya-Kaneda, Takuji Yoshimura, Atsushi Tanemura, Ichiro Katayama
Accumulating evidence has described the involvement of mTOR complex 1 (mTORC1) signaling in pigmentation regulation; however, the precise mechanism is not fully understood. Here, we generated mice with conditional deletion of the mTORC1 suppressor tuberous sclerosis complex 2 (Tsc2) in melanocytes. It resulted in constitutive hyperactivation of mTORC1 and reduced skin pigmentation. Mechanistically, neither the number of melanocytes nor the expression of melanogenesis-related enzymes was decreased; however, endoplasmic reticulum (ER) and mitochondrial oxidative stress, and lower melanization in melanosomes were observed...
October 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29058282/roles-of-tgf-%C3%AE-signaling-pathway-in-endoplasmic-reticulum-stress-in-endothelial-cells-stimulated-with-cigarette-smoke-extract
#15
Hong Huang, Qiu-Li Ding, Hui-Fen Zhu, Dao-Feng Yang
To investigate the role of signaling pathway in the effect of endoplasmic reticulum stress (ER stress) in endothelial cells stimulated with cigarette smoke extract (CSE). Human umbilical vein endothelial cells (HUVECs) were cultured and divided into 3 groups: CSE-stimulated group, CSE-stimulated with 4-PBA group, and negative control group. HUVECs were cultured and stimulated with CSE at concentrations of 5%, 10% and 20%, respectively, mRNA of CXCL-8 and GRP78 was detected by real-time PCR. ELISA was performed to test the expression of CXCL-8 protein, and neutrophils migration was detected by Transwell board test...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29045791/efficient-and-high-color-purity-light-emitting-diodes-based-on-in-situ-grown-films-of-cspbx3-x-br-i-nanoplates-with-controlled-thicknesses
#16
Junjie Si, Yang Liu, Zhuofei He, Hui Du, Kai Du, Dong Chen, Jing Li, Mengmeng Xu, He Tian, Haiping He, Dawei Di, Changqing Lin, Yingchun Cheng, Jianpu Wang, Yizheng Jin
We report a facile solution-based approach to the in situ growth of perovskite films consisting of monolayers of CsPbBr3 nanoplates passivated by bulky phenylbutylammonium (PBA) cations, that is, two-dimensional layered PBA2(CsPbBr3)n-1PbBr4 perovskites. Optimizing film formation processes leads to layered perovskites with controlled n values in the range of 12-16. The layered perovskite emitters show quantum-confined band gap energies with a narrow distribution, suggesting the formation of thickness-controlled quantum-well (TCQW) structures...
October 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/29045036/endoplasmic-reticulum-stress-regulates-oxygen-glucose-deprivation-induced-parthanatos-in-human-sh-sy5y-cells-via-improvement-of-intracellular-ros
#17
Hai-Feng Wang, Zong-Qi Wang, Ye Ding, Mei-Hua Piao, Chun-Sheng Feng, Guang-Fan Chi, Yi-Nan Luo, Peng-Fei Ge
AIMS: Endoplasmic reticulum (ER) stress has been demonstrated to regulate neuronal death caused by ischemic insults via activation of apoptosis, but it still remains unclear whether ER stress participates in regulation of parthanatos, a new type of programmed cell death characterized by PARP-1 overactivation and intracellular accumulation of PAR polymer. METHODS: we used oxygen-glucose deprivation (OGD) and human SH-SY5Y cells to simulate neuronal damage caused by ischemia...
October 16, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29040392/%C3%AE-cypermethrin-and-its-metabolite-3-phenoxybenzoic-acid-exhibit-immunotoxicity-in-murine-macrophages
#18
Xia Wang, Bingnan He, Baida Kong, Lai Wei, Rong Wang, Chenqian Zhou, Yiyan Shao, Jiajia Lin, Yuanxiang Jin, Zhengwei Fu
β-Cypermethrin (β-CYP), one of most important pyrethroids, is widely used to control insects, and has been detected in organisms, including human. Pyrethroids have been shown to pose neurotoxicity, hepatotoxicity, endocrine disruption and reproductive risks in mammals. However, research in immunotoxicity of pyrethroids, especially their metabolites, is limited. A common metabolite of pyrethroids is 3-phenoxybenzoic acid (3-PBA) in mammals. Thus, in this study, we evaluated the immunotoxicity of β-CYP and 3-PBA in mouse macrophages, RAW 264...
October 11, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29036897/inhibition-of-starvation-triggered-endoplasmic-reticulum-stress-autophagy-and-apoptosis-in-arpe-19-cells-by-taurine-through-modulating-the-expression-of-calpain-1-and-calpain-2
#19
Yuanyuan Zhang, Shu Ren, Yuci Liu, Kun Gao, Zheng Liu, Zhou Zhang
Age-related macular degeneration (AMD) is a complex disease with multiple initiators and pathways that converge on death for retinal pigment epithelial (RPE) cells. In this study, effects of taurine on calpains, autophagy, endoplasmic reticulum (ER) stress, and apoptosis in ARPE-19 cells (a human RPE cell line) were investigated. We first confirmed that autophagy, ER stress and apoptosis in ARPE-19 cells were induced by Earle's balanced salt solution (EBSS) through starvation to induce RPE metabolic stress...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29034874/pathogenesis-of-plasmodium-berghei-anka-infection-in-the-gerbil-meriones-unguiculatus-as-an-experimental-model-for-severe-malaria
#20
Quazim Olawale Junaid, Loke Tim Khaw, Rohela Mahmud, Kien Chai Ong, Yee Ling Lau, Prajakta Uttam Borade, Jonathan Wee Kent Liew, Sinnadurai Sivanandam, Kum Thong Wong, Indra Vythilingam
BACKGROUND: As the quest to eradicate malaria continues, there remains a need to gain further understanding of the disease, particularly with regard to pathogenesis. This is facilitated, apart from in vitro and clinical studies, mainly via in vivo mouse model studies. However, there are few studies that have used gerbils (Meriones unguiculatus) as animal models. Thus, this study is aimed at characterizing the effects of Plasmodium berghei ANKA (PbA) infection in gerbils, as well as the underlying pathogenesis...
2017: Parasite: Journal de la Société Française de Parasitologie
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