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Streptococcus suis

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https://www.readbyqxmd.com/read/27905502/immune-responsiveness-of-cd4-t-cells-during-streptococcus-suis-serotype-2-infection
#1
Marie-Pier Lecours, Corinne Letendre, Damian Clarke, Paul Lemire, Tristan Galbas, Marie-Odile Benoit-Biancamano, Jacques Thibodeau, Marcelo Gottschalk, Mariela Segura
The pathogenesis of Streptococcus suis infection, a major swine and human pathogen, is only partially understood and knowledge on the host adaptive immune response is critically scarce. Yet, S. suis virulence factors, particularly its capsular polysaccharide (CPS), enable this bacterium to modulate dendritic cell (DC) functions and potentially impair the immune response. This study aimed to evaluate modulation of T cell activation during S. suis infection and the role of DCs in this response. S. suis-stimulated total mouse splenocytes readily produced TNF-α, IL-6, IFN-γ, CCL3, CXCL9, and IL-10...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27869755/distribution-of-type-i-restriction-modification-systems-in-streptococcus-suis-an-outlook
#2
Niels Willemse, Constance Schultsz
Streptococcus suis is a porcine commensal and pathogen with zoonotic potential. We recently identified a novel Type I restriction-modification (R-M) system in a zoonotic S. suis clone which has emerged in the Netherlands. Here, we describe the DNA inversions in the specificity subunit of this system in S. suis serotype 2, clonal complex 20 and explain the absence of domain movement by the absence of repeats. In addition, we identified a core Type I R-M system present in 95% of the isolates and found an association of the distribution of Type I R-M systems in the S...
November 18, 2016: Pathogens
https://www.readbyqxmd.com/read/27847975/mac-protein-is-not-an-essential-virulence-factor-for-the-virulent-reference-strain-streptococcus-suis-p1-7
#3
Genhui Xiao, Zongfu Wu, Shouming Zhang, Huanyu Tang, Fengqiu Wang, Chengping Lu
Streptococcus suis is a major pathogen of pigs and also an important zoonotic agent for humans. A S. suis protein containing Mac-1 domain (designated Mac) is a protective antigen, exclusively cleaves porcine IgM, and contributes to complement evasion with the presence of high titers of specific porcine anti-S. suis IgM, but its role in S. suis virulence has not been investigated in natural healthy host without specific IgM. In this study, a mac deletion mutant was constructed by homologous recombination in S...
November 15, 2016: Current Microbiology
https://www.readbyqxmd.com/read/27834729/structural-and-functional-analysis-of-an-anchorless-fibronectin-binding-protein-fbps-from-gram-positive-bacterium-streptococcus-suis
#4
Abednego Moki Musyoki, Zhongyu Shi, Chunling Xuan, Guangwen Lu, Jianxun Qi, Feng Gao, Beiwen Zheng, Qiangmin Zhang, Yan Li, Joel Haywood, Cuihua Liu, Jinghua Yan, Yi Shi, George F Gao
The anchorless fibronectin-binding proteins (FnBPs) are a group of important virulence factors for which the structures are not available and the functions are not well defined. In this study we performed comprehensive studies on a prototypic member of this group: the fibronectin-/fibrinogen-binding protein from Streptococcus suis (FBPS). The structures of the N- and C-terminal halves (FBPS-N and FBPS-C), which together cover the full-length protein in sequence, were solved at a resolution of 2.1 and 2.6 Å, respectively, and each was found to be composed of two domains with unique folds...
November 10, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27830834/suilysin-induced-platelet-neutrophil-complexes-formation-is-triggered-by-pore-formation-dependent-calcium-influx
#5
Shengwei Zhang, Yuling Zheng, Shaolong Chen, Shujing Huang, Keke Liu, Qingyu Lv, Yongqiang Jiang, Yuan Yuan
Platelet activation and platelet-neutrophil interactions have been found to be involved in inflammation, organ failure and soft-tissue necrosis in bacterial infections. Streptococcus suis, an emerging human pathogen, can cause streptococcal toxic-shock syndrome (STSS) similarly to Streptococcus pyogenes. Currently, S. suis-platelet interactions are poorly understood. Here, we found that suilysin (SLY), the S. suis cholesterol-dependent cytolysin (CDC), was the sole stimulus of S. suis that induced platelet-neutrophil complexes (PNC) formation...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27821092/human-meningitis-due-to-streptococcus-suis-in-lom%C3%A3-togo-a-case-report
#6
Mireille Prince-David, Mounerou Salou, Corinne Marois-Créhan, Komi Assogba, Céline Plainvert, Koffi A Balogou, Claire Poyart, Asmaa Tazi
BACKGROUND: Streptococcus suis is a zoonotic pathogen which represents the leading cause of meningitis in Southeast Asia and an emerging pathogen in the Western world, the main risk factor for infection being contact with pigs. In Africa, the prevalence of S. suis infections in swine and humans is largely unrecognized, with only one recent report of a limited case series. CASE PRESENTATION: We describe a human case of meningitis due to S. suis in a 32-year-old man living in Togo...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27816682/acute-meningitis-of-piglets-and-mice-caused-by-co-infected-with-streptococcus-suis-and-aerococcus-viridans
#7
Zihao Pan, Ye Ma, Jiale Ma, Wenyang Dong, Huochun Yao
The two opportunistic pathogens, Streptococcus suis (S. suis) and Aerococcus. viridans (A. viridans) were isolated from the brains of piglets suffered bacterial meningitis in a farm of China. The murine model has been established to evaluate the pathogenicity and symbiotic relationship of S. suis and A. viridans simultaneously infection. Our results demonstrated the ability of new serotype S. suis to cause the classical bacterial meningitis and death were greatly enhanced during co-infection with A. viridans in mice at a proportion...
November 2, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27812354/sub-mics-of-azithromycin-decrease-biofilm-formation-of-streptococcus-suis-and-increase-capsular-polysaccharide-content-of-s-suis
#8
Yan-Bei Yang, Jian-Qing Chen, Yu-Lin Zhao, Jing-Wen Bai, Wen-Ya Ding, Yong-Hui Zhou, Xue-Ying Chen, Di Liu, Yan-Hua Li
Streptococcus suis (S. suis) caused serious disease symptoms in humans and pigs. S. suis is able to form thick biofilms and this increases the difficulty of treatment. After growth with 1/2 minimal inhibitory concentration (MIC) of azithromycin, 1/4 MIC of azithromycin, or 1/8 MIC of azithromycin, biofilm formation of S. suis dose-dependently decreased in the present study. Furthermore, scanning electron microscopy analysis revealed the obvious effect of azithromycin against biofilm formation of S. suis. Especially, at two different conditions (1/2 MIC of azithromycin non-treated cells and treated cells), we carried out comparative proteomic analyses of cells by using iTRAQ technology...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27800304/effects-of-suilysin-on-streptococcus-suis-induced-platelet-aggregation
#9
Shengwei Zhang, Junping Wang, Shaolong Chen, Jiye Yin, Zhiyuan Pan, Keke Liu, Lin Li, Yuling Zheng, Yuan Yuan, Yongqiang Jiang
Blood platelets play important roles during pathological thrombocytopenia in streptococcal toxic shock syndrome (STSS). Streptococcus suis (S. suis) an emerging human pathogen, can cause STSS similarly to S. pyogenes. However, S. suis interactions with platelets are poorly understood. Here, we found that suilysin (SLY), different from other bacterial cholesterol-dependent cytolysins (CDCs), was the sole stimulus that induced platelet aggregation. Furthermore, the inside-out activation of GPIIb/IIIa of platelets mediated SLY-induced platelet aggregation...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27795476/a-decennium-of-etiology-and-antimicrobial-susceptibility-patterns-in-patients-with-infective-endocarditis-at-a-university-hospital-thailand
#10
Chotirat Nakaranurack, Chankit Puttilerpong, Gompol Suwanpimolkul
Infective endocarditis is an infection with a high mortality rate. Antimicrobial therapy is important in treatment but data on antimicrobial susceptibilities are limited. This retrospective study analyzed the data of causative microorganisms and antimicrobial susceptibility patterns in patients with infective endocarditis who were aged 18 years or older and received inpatient care between 2006 and 2015 at King Chulalongkorn Memorial Hospital. A total of 213 patients fulfilled the inclusion criteria. Streptococcus spp...
October 31, 2016: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27774436/evolution-and-diversity-of-the-antimicrobial-resistance-associated-mobilome-in-streptococcus-suis-a-probable-mobile-genetic-elements-reservoir-for-other-streptococci
#11
Jinhu Huang, Jiale Ma, Kexin Shang, Xiao Hu, Yuan Liang, Daiwei Li, Zuowei Wu, Lei Dai, Li Chen, Liping Wang
Streptococcus suis is a previously neglected, newly emerging multidrug-resistant zoonotic pathogen. Mobile genetic elements (MGEs) play a key role in intra- and interspecies horizontal transfer of antimicrobial resistance (AMR) determinants. Although, previous studies showed the presence of several MGEs, a comprehensive analysis of AMR-associated mobilome as well as their interaction and evolution has not been performed. In this study, we presented the AMR-associated mobilome and their insertion hotspots in S...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27756321/egfr-transactivation-contributes-to-neuroinflammation-in-streptococcus-suis-meningitis
#12
Xiao-Pei Yang, Ji-Yang Fu, Rui-Cheng Yang, Wen-Tong Liu, Tao Zhang, Bo Yang, Ling Miao, Bei-Bei Dou, Chen Tan, Huan-Chun Chen, Xiang-Ru Wang
BACKGROUND: Streptococcus suis serotype 2 (SS2) is an important zoonotic bacterial pathogen in both humans and animals, which can cause high morbidity and mortality. Meningitis is one of the major clinical manifestations of SS2 infection. However, the specific process of SS2 meningitis and its molecular mechanisms remain unclear. Epidermal growth factor receptor (EGFR) has been reported to initiate transduction of intracellular signals and regulate host inflammatory responses. Whether and how EGFR contributes to the development of S...
October 19, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27749921/novel-igg-degrading-enzymes-of-the-igde-protease-family-link-substrate-specificity-to-host-tropism-of-streptococcus-species
#13
Christian Spoerry, Pontus Hessle, Melanie J Lewis, Lois Paton, Jenny M Woof, Ulrich von Pawel-Rammingen
Recently we have discovered an IgG degrading enzyme of the endemic pig pathogen S. suis designated IgdE that is highly specific for porcine IgG. This protease is the founding member of a novel cysteine protease family assigned C113 in the MEROPS peptidase database. Bioinformatical analyses revealed putative members of the IgdE protease family in eight other Streptococcus species. The genes of the putative IgdE family proteases of S. agalactiae, S. porcinus, S. pseudoporcinus and S. equi subsp. zooepidemicus were cloned for production of recombinant protein into expression vectors...
2016: PloS One
https://www.readbyqxmd.com/read/27738916/use-of-antibiotics-and-antimicrobial-resistance-in-veterinary-medicine-as-exemplified-by-the-swine-pathogen-streptococcus-suis
#14
Maren Seitz, Peter Valentin-Weigand, Jörg Willenborg
Use of antimicrobial agents in veterinary medicine is essential to control infectious diseases, thereby keeping animals healthy and animal products safe for the consumer. On the other hand, development and spread of antimicrobial resistance is of major concern for public health. Streptococcus (S.) suis reflects a typical bacterial pathogen in modern swine production due to its facultative pathogenic nature and wide spread in the pig population. Thus, in the present review we focus on certain current aspects and problems related to antimicrobial use and resistance in S...
October 15, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27716292/serological-patterns-of-actinobacillus-pleuropneumoniae-mycoplasma-hyopneumoniae-pasteurella-multocida-and-streptococcus-suis-in-pig-herds-affected-by-pleuritis
#15
Per Wallgren, Erik Nörregård, Benedicta Molander, Maria Persson, Carl-Johan Ehlorsson
BACKGROUND: Respiratory illness is traditionally regarded as the disease of the growing pig, and has historically mainly been associated to bacterial infections with focus on Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae. These bacteria still are of great importance, but continuously increasing herd sizes have complicated the scenario and the influence of secondary invaders may have been increased. The aim of this study was to evaluate the presence of A. pleuropneumoniae and M...
October 4, 2016: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/27697171/survival-of-streptococcus-suis-streptococcus-dysgalactiae-and-trueperella-pyogenes-in-dry-cured-iberian-pork-shoulders-and-loins
#16
F Cardoso-Toset, I Luque, A Morales-Partera, A Galán-Relaño, B Barrero-Domínguez, M Hernández, J Gómez-Laguna
Dry-cured hams, shoulders and loins of Iberian pigs are highly appreciated in national and international markets. Salting, additive addition and dehydration are the main strategies to produce these ready-to-eat products. Although the dry curing process is known to reduce the load of well-known food borne pathogens, studies evaluating the viability of other microorganisms in contaminated pork have not been performed. In this work, the efficacy of the dry curing process to eliminate three swine pathogens associated with pork carcass condemnation, Streptococcus suis, Streptococcus dysgalactiae and Trueperella pyogenes, was evaluated...
February 2017: Food Microbiology
https://www.readbyqxmd.com/read/27694240/novel-capsular-polysaccharide-loci-and-new-diagnostic-tools-for-high-throughput-capsular-gene-typing-in-streptococcus-suis
#17
Xiaotong Qiu, Xuemei Bai, Ruiting Lan, Han Zheng, Jianguo Xu
: Streptococcus suis is an important pathogen of pigs and may cause serious disease in humans. Serotyping is an important tool in diagnosis and epidemiological studies of S. suis. Thirty-three reference serotypes and 9 novel cps loci (NCL) are recognized in S. suis To gain a better understanding of the prevalence and genetic characteristics of NCLs, we investigated the serotype identity of 486 isolates isolated between 2013 and 2015 in China by capsular gene typing methods. Two hundred and seventy six isolates carried NCL belonging to 16 groups, 8 of which were first reported in this study...
September 30, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27689249/predominance-of-streptococcus-suis-st1-and-st7-in-human-cases-in-china-and-detection-of-a-novel-sequence-type-st658
#18
Yang Zhou, Xingxing Dong, Zhiwei Li, Geng Zou, Li Lin, Xiaohong Wang, Huanchun Chen, Robin B Gasser, Jinquan Li
No abstract text is available yet for this article.
September 30, 2016: Virulence
https://www.readbyqxmd.com/read/27689023/human-case-of-bacteremia-due-to-streptococcus-suis-serotype-5-in-japan-the-first-report-and-literature-review
#19
Daisuke Taniyama, Mayu Sakurai, Tetsuya Sakai, Takahide Kikuchi, Takashi Takahashi
Streptococcus suis is a zoonotic pathogen that can be transferred from pigs to humans. The serotypes 2 and 14 are prevalent among patients with S. suis infections, while other serotypes (i.e., 1, 4, 5, 16, and 24) have been detected in rare human cases. To the best of our knowledge, the present patient handling with raw pork is the first human case of uncomplicated bacteremia due to S. suis serotype 5 in Japan. We confirmed the new sequence type 752 of this isolate. Virulence-associated gene profiling was performed; both sly (encoding the hemolysin suilysin) and mrp (encoding a muramidase-released protein) were detected without amplification of epf (encoding the extracellular factor)...
2016: IDCases
https://www.readbyqxmd.com/read/27666982/selection-of-potential-virulence-factors-contributing-to-streptococcus-suis-type-2-penetration-into-the-blood-brain-barrier-in-an-in-vitro-co-culture-model
#20
Hongtao Liu, Seng Zhu, Yingying Sun, Na Li, Jingmin Gu, Changjiang Sun, Xin Feng, Wenyu Han, Jian Xia Jiang, Liancheng Lei
Meningitis caused by Streptococcus suis type 2 (S. suis 2) is a great threat to the pig industry and human health. Virulence factors associated with the pathogenesis of meningitis have yet to be clearly defined, even though many potential S. suis 2 virulence factors have been identified. This greatly hinders the progress of S. suis 2 meningitis pathogenesis research. In this study, a co-culture blood brain barrier (BBB) model was established using primary porcine brain microvascular endothelial cells and astrocytes, and the whole genome library of S...
September 23, 2016: Journal of Microbiology and Biotechnology
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