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Streptococcus suis

Xavier Fernández-Aguilar, Marcelo Gottschalk, Virginia Aragon, Jordi Càmara, Carmen Ardanuy, Roser Velarde, Nuria Galofré-Milà, Raquel Castillo-Contreras, Jorge R López-Olvera, Gregorio Mentaberre, Andreu Colom-Cadena, Santiago Lavín, Oscar Cabezón
Urban wild boars (Sus scrofa) from Barcelona, Spain, harbor great diversity of Streptococcus suis strains, including strains with the cps2 gene and with the same molecular profile as local human cases. The increasing trend of potential effective contacts for S. suis transmission is of public health concern.
June 2018: Emerging Infectious Diseases
Silvia Fillo, Fabiola Mancini, Anna Anselmo, Antonella Fortunato, Giovanni Rezza, Florigio Lista, Alessandra Ciervo
Streptococcus suis is an economically important pathogen in the pig industry and is also an emerging zoonotic agent responsible for severe infections in humans. Here, we report the genome sequence of S. suis strain SsRC-1. Specifically, this strain was a serotype 2 and was isolated from a human fatal case of toxic shock syndrome (TSS) in Italy.
May 17, 2018: Genome Announcements
Rui-Li Zhao, Lin Zhu, Meng-Yue Liu, Tian-Ming Jin, Ji-Fei Ma, Ye Hu, Xuan Wang, Shun-Yi Qin, Jian-Bao Chen
Lectin has attracted attention because of its ability to serve as a carrier for targeted drug delivery. Large lectins isolated from marine invertebrates and crustaceans have strong immunogenicity and adverse effects, which limit their usefulness. This study reports the identification of catesbeianalectin via screening a bullfrog skin cDNA library. The catesbeianalectin polypeptide has a molecular weight of 1.47 kD, making it the smallest known lectin in terms of molecular weight. Circular dichroism analysis showed a PPII helix secondary structure...
May 2018: Pakistan Journal of Pharmaceutical Sciences
Yan-Hua Li, Yong-Hui Zhou, Yong-Zhi Ren, Chang-Geng Xu, Xin Liu, Bing Liu, Jian-Qing Chen, Wen-Ya Ding, Yu-Lin Zhao, Yan-Bei Yang, Shuai Wang, Di Liu
Streptococcus suis is difficult to treat and responsible for various infections in humans and pigs. It can also form biofilms and induce persistent infections. Rhizoma Coptidis is a medicinal plant widely used in Traditional Chinese Medicine. Although the inhibitory effects of Rhizoma Coptidis on biofilm formation have been investigated in several studies, the ability of Rhizoma Coptidis to inhibit S. suis biofilm formation and the underlying mechanisms have not yet been reported. In this study, we showed that sub-minimal inhibitory concentrations (25 and 50 μg mL-1 ) of water extracts of Rhizoma Coptidis ( Coptis deltoidea C...
2018: Frontiers in Pharmacology
Xiaojun Zhong, Yue Zhang, Yinchu Zhu, Wenyang Dong, Jiale Ma, Zihao Pan, Shipra Roy, Chengping Lu, Huochun Yao
Streptococcus suis has received increasing attention for its involvement in severe human infections worldwide, as well as in multidrug resistance. Two-component signaling systems (TCSSs) play important roles in bacterial adaptation to various environmental stimuli. In this study, we identified a novel TCSS encoded in S. suis serotype 2 (SS2), designated as VraSRSS , which is involved in bacterial pathogenicity and susceptibility to antimicrobials. Our data demonstrated that the yvqFSS gene located upstream of vraSRSS shared the same promoter with the TCSS genes, which was directly regulated by VraSRSS as showed in electrophoretic mobility shift assays...
April 23, 2018: Infection and Immunity
Wandee Sirichokchatchawan, Puwiya Pupa, Prasert Praechansri, Nutthee Am-In, Somboon Tanasupawat, Piengchan Sonthayanon, Nuvee Prapasarakul
Lactic acid bacteria (LAB) play an important role in pig health and performance that arises from their beneficial impacts on the balance of gastrointestinal microbes, ability to fight enteric pathogens, and capacity to support the immune system. The aim of this study was to evaluate the functional and safety aspects of five previously isolated autochthonous LAB strains, (Lactobacillus plantarum 22F, 25F and 31F, Pediococcus acidilactici 72N and Pediococcus pentosaceus 77F) from pig faeces as potential probiotics for a pig feed supplement...
April 17, 2018: Microbial Pathogenesis
David Roy, Daisuke Takamatsu, Masatoshi Okura, Guillaume Goyette-Desjardins, Marie-Rose Van Calsteren, Audrey Dumesnil, Marcelo Gottschalk, Mariela Segura
The capsular polysaccharide (CPS) represents a key virulence factor for most encapsulated streptococci. Streptococcus suis and Group B Streptococcus (GBS) are both well-encapsulated pathogens of clinical importance in veterinary and/or human medicine and responsible for invasive systemic diseases. S. suis and GBS are the only Gram-positive bacteria which express a sialylated CPS at their surface. An important difference between these two sialylated CPSs is the linkage between the side-chain terminal galactose and sialic acid, being α-2,6 for S...
2018: Frontiers in Microbiology
Mari Tohya, Tsutomu Sekizaki, Tohru Miyoshi-Akiyama
Streptococcus ruminantium sp. nov. of type strain GUT-187T, previously classified as Streptococcus suis serotype 33, is a recently described novel streptococcal species. This study was designed to determine the complete genome sequence of S. ruminantium GUT-187T using a combination of Oxford Nanopore and the Illumina platform, and to compare this sequence with the genomes of 27 S. suis representative strains. The genome of GUT-187T was 2,090,539 bp in size, with a GC content of 40.01%. This genome contained 1,961 predicted protein coding DNA sequences (CDSs); of these, 1,685 (85...
April 1, 2018: Genome Biology and Evolution
Liping Feng, Xiaona Niu, Wen Mei, Weitian Li, Yuan Liu, Stephan P Willias, Chao Yuan, Weicheng Bei, Xiaohong Wang, Jinquan Li
Vaccine development efforts against Streptococcus suis serotype 2 (S. suis 2) are often constrained by strain/serotype antigen variability. Bioinformatics analyses revealed two highly conserved S. suis 2 factors, EF-Tu and FtsZ. Murine immunization with recombinant proteins emulsified in white oil adjuvant or eukaryotic DNA vaccine vectors provided significant protection against lethal S. suis 2 challenge. Immune responses elicited by recombinant protein immunization revealed the robust generation of humoral immune responses, with a mixed induction of Th1-type and Th2-type responses...
April 4, 2018: Vaccine
L Zhang, J Wang, W Xu, Y Sun, J You, H Lu, Y Song, J Wei, L Li
Our previous studies have shown that Magnolol (Mag) improves the symptoms and decreases the levels of cytokines during infection induced by Streptococcus suis (S. suis) in mice. Although some reports show that Mag inhibits lipopolysaccharide-induced inflammatory responses via downregulating mitogen-activated protein kinases (MAPK) and nuclear factor-κB (NF-κB) signaling pathways, the molecular mechanisms underlying Mag-mediated inhibition of S. suis-induced inflammatory responses are poorly understood. Here, RAW264...
March 2018: Polish Journal of Veterinary Sciences
Li Han, Lei Fu, Yongbo Peng, Anding Zhang
Streptococcus suis infections can cause septic shock, which is referred to as streptococcal toxic-shock-like syndrome (STSLS). The disease is characterized by a severe inflammatory response, multiple organ failure, and high mortality. However, no superantigen that is responsible for toxic shock syndrome was detected in S. suis , indicating that the mechanism underlying STSLS is different and remains to be elucidated. Triggering receptor expressed on myeloid cells-1 (TREM-1), belonging to the Ig superfamily, is an activating receptor expressed on myeloid cells, and has been recognized as a critical immunomodulator in several inflammatory diseases of both infectious and non-infectious etiologies...
2018: Frontiers in Immunology
Hua Ni, Weiwei Fan, Chaolong Li, Qianqian Wu, Hongfen Hou, Dan Hu, Feng Zheng, Xuhui Zhu, Changjun Wang, Xiangrong Cao, Zhu-Qing Shao, Xiuzhen Pan
Streptococcus suis serotype 2 is an important swine pathogen and an emerging zoonotic agent that causes severe infections. Recent studies have reported a eukaryotic-like Ser/Thr protein kinase (STK) gene and characterized its role in the growth and virulence of different S. suis 2 strains. In the present study, phosphoproteomic analysis was adopted to identify substrates of the STK protein. Seven proteins that were annotated to participate in different cell processes were identified as potential substrates, which suggests the pleiotropic effects of stk on S...
2018: Frontiers in Cellular and Infection Microbiology
Feng Zheng, Zhu-Qing Shao, Xina Hao, Qianqian Wu, Chaolong Li, Hongfen Hou, Dan Hu, Changjun Wang, Xiuzhen Pan
The oligopeptide permease (Opp) cassette, an oligopeptide transport system belongs to the superfamily of ATP-binding cassette (ABC) transporter, is widely distributed in bacteria, including Streptococcus suis (S. suis). It is encoded by the opp operon containing oppA, oppB, oppC, oppD, and oppF. In addition to the uptake of peptide, the oppA gene also plays an important role in virulence of many pathogens. In this study, an oppA homologue from the highly virulent S. suis serotype 2 (S. suis 2) strain 05ZYH33 was identified...
March 31, 2018: Microbial Pathogenesis
Marisa Haenni, Agnese Lupo, Jean-Yves Madec
The genus Streptococcus includes Gram-positive organisms shaped in cocci and organized in chains. They are commensals, pathogens, and opportunistic pathogens for humans and animals. Most Streptococcus species of veterinary relevance have a specific ecological niche, such as S. uberis , which is almost exclusively an environmental pathogen causing bovine mastitis. In contrast, S. suis can be considered as a true zoonotic pathogen, causing specific diseases in humans after contact with infected animals or derived food products...
March 2018: Microbiology Spectrum
Désirée Vötsch, Maren Willenborg, Yenehiwot B Weldearegay, Peter Valentin-Weigand
Streptococcus (S.) suis is a frequent early colonizer of the upper respiratory tract of pigs. In fact, it is difficult to find S. suis -free animals under natural conditions, showing the successful adaptation of this pathogen to its porcine reservoir host. On the other hand, S. suis can cause life-threatening diseases and represents the most important bacterial cause of meningitis in pigs worldwide. Notably, S. suis can also cause zoonotic infections, such as meningitis, septicemia, endocarditis, and other diseases in humans...
2018: Frontiers in Microbiology
Christine Unterweger, Ursula Ruczizka, Joachim Spergser, Christoph Georg Baums, Isabel Hennig-Pauka
In newborn piglets treatment with long-acting ceftiofur is a common approach to reduce losses due to streptococcal diseases on farms, even if problems start after weaning. The purpose of this study was to examine the influence of a single early-life treatment on Streptococcus (S.) suis colonization, transmission, immunoreaction, and drug resistance over an observation period of 14 weeks. In a farm with a history of streptococcal disease and isolation of a S. suis cps 7 mrp +, arc A+ isolate from diseased piglets, half of each litter was treated with a long-acting ceftiofur on day 1...
March 29, 2018: Pathogens
Wenya Ding, Jin Sun, He Lian, Changgeng Xu, Xin Liu, Sidi Zheng, Dong Zhang, Xiaopeng Han, Yanyan Liu, Xueying Chen, Bello O God Spower, Yanhua Li
Biofilm is one of the most important physiological protective barriers of the Streptococcus suis ( S. suis ), and it is also one of the primary causes of hindrance to drug infiltration, reduction of bactericidal effects, and the development of antibiotic resistance. In order to intervene or eliminate S. suis biofilm, shuttle-shape emodin-loaded nanoparticles were developed in our study. The emodin nanoparticles were prepared by emodin and gelatin-cyclodextrin which was synthesized as drug carrier, and the nanoparticles were 174 nm in size, -4...
2018: Frontiers in Pharmacology
Jacek Dutkiewicz, Violetta Zając, Jacek Sroka, Bernard Wasiński, Ewa Cisak, Anna Sawczyn, Anna Kloc, Angelina Wójcik-Fatla
<i>Streptococcus suis</i> is a re-emerging zoonotic pathogen that may cause severe disease, mostly meningitis, in pigs and in humans having occupational contact with pigs and pork, such as farmers, slaughterhose workers and butchers. The first stage of the pathogenic process, similar in pigs and humans, is adherence to and colonisation of mucosal and/or epithelial surface(s) of the host. The second stage is invasion into deeper tissue and extracellular translocation of bacterium in the bloodstream, either free in circulation or attached to the surface of monocytes...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
Fabiana C de Aguiar, Ana Lucía Solarte, Carmen Tarradas, Inmaculada Luque, Alfonso Maldonado, Ángela Galán-Relaño, Belén Huerta
The inhibitory potential by contact and vapor of basil, cinnamon, clove, peppermint, oregano, rosemary, common thyme, and red thyme essential oils (EOs) against 20 strains of Streptococcus suis was determined by the disk diffusion test. The broth microdilution method was used to determine the minimal inhibitory and minimal bactericidal concentration (MIC and MBC) of the four selected oils. Furthermore, the bactericidal power (ratio MBC/MIC) was calculated. The EOs with the major potential in the disk diffusion method were red thyme, common thyme, oregano, and cinnamon (∅ mean 16...
March 24, 2018: MicrobiologyOpen
Jiaqing Luo, Hongchao Sun, Xianfeng Zhao, Suhua Wang, Xunhui Zhuo, Yi Yang, Xueqiu Chen, Chaoqun Yao, Aifang Du
The immunochromatographic test (ICT) is a convenient and low-cost method that can rapidly obtain results (10 min) under normal conditions. In this study, we established an ICT assay with two monoclonal antibodies: TgSAG3-3A7 and TgSAG3-4D5 based on the conserved protein of TgSAG3 that can be expressed in all the infective stages of T. gondii. 20 nm gold particles were prepared and conjugated with TgSAG3-3A7 MAb at the concentration of 12.5 μg/mL. TgSAG3-4D5 MAb were used as the capture antibody because of its higher affinity tested by ELISA...
March 15, 2018: Veterinary Parasitology
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