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Streptococcus suis

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https://www.readbyqxmd.com/read/29148386/human-case-of-streptococcus-suis-disease-ontario-canada
#1
Jeisa Gomez-Torres, Asim Nimir, James Cluett, Anita Aggarwal, Sameer Elsayed, Deirdre Soares, Sarah Teatero, Yan Chen, Marcelo Gottschalk, Nahuel Fittipaldi
We report a case of Streptococcus suis human disease in Ontario, Canada, caused by a serotype 2 strain genotypically similar to those commonly isolated from pigs in North America. Initially, the isolate was misidentified as a viridans group Streptococcus. Human S. suis infections may be underdiagnosed in North America.
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29139136/tilmicosin-and-florfenicol-loaded-hydrogenated-castor-oil-solid-lipid-nanoparticles-to-pigs-combined-antibacterial-activities-and-pharmacokinetics
#2
Z Ling, L Yonghong, L Junfeng, Z Li, L Xianqiang
The combined antibacterial effects of tilmicosin (TIL) and florfenicol (FF) against Actinobacillus pleuropneumoniae (APP) (n = 2), Streptococcus suis (S. suis) (n = 2), and Haemophilus parasuis (HPS) (n = 2) were evaluated by chekerboard test and time-kill assays. The pharmacokinetics (PKs) of TIL- and FF-loaded hydrogenated castor oil (HCO)-solid lipid nanoparticles (SLN) were performed in healthy pigs. The results indicated that TIL and FF showed synergistic or additive antibacterial activities against APP, S...
November 15, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29122409/understanding-the-virulence-of-streptococcus-suis-a-veterinary-medical-and-economic-challenge
#3
REVIEW
B Haas, D Grenier
Streptococcus suis is a major swine pathogen worldwide and causes considerable economic losses in the swine industry. S. suis is also an emerging zoonotic agent, mainly in Asia. In pigs and humans, S. suis can cause septicemia, pneumonia, endocarditis, arthritis, and meningitis with irreversible sequelae. Identification and characterization of the virulence factors produced by S. suis are major advances in the understanding of the pathogenesis of S. suis infections and has therefore opened promising avenues for vaccine development against this pathogen...
November 6, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29094420/rationally-designed-chemically-modified-glycodendrimer-ligand-analogues-inhibit-streptococcus-suis-adhesin-sadp-in-picomolar-concentrations
#4
Sauli Haataja, Priya Verma, Ou Fu, Anastassios Papageorgiou, Sakari Pöysti, Roland Pieters, Ulf Nilsson, Jukka Finne
Host cell surface carbohydrate receptors of bacterial adhesins are attractive targets in anti-adhesion therapy. The affinity of carbohydrate ligands with adhesins is usually found in a low µM range, which poses a problem for the design of effective inhibitors useful in therapy. In an attempt to increase the inhibitory power of carbohydrate ligands, we have combined the approach of chemical modification of ligands with their presentation as multivalent dendrimers in the design of an inhibitor of streptococcal adhesin SadP binding to its galactosyl-α1-4-galactose (galabiose) receptor...
November 2, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29033841/pharmacodynamic-evaluation-and-pk-pd-based-dose-prediction-of-tulathromycin-a-potential-new-indication-for-streptococcus-suis-infection
#5
Yu-Feng Zhou, Hui-Min Peng, Ming-Xiao Bu, Ya-Hong Liu, Jian Sun, Xiao-Ping Liao
Tulathromycin is the first member of the triamilide antimicrobial drugs that has been registered in more than 30 countries. The goal of this study is to provide a potential new indication of tulathromycin for Streptococcus suis infections. We investigated the pharmacokinetic and ex vivo pharmacodynamics of tulathromycin against experimental S. suis infection in piglets. Tulathromycin demonstrated a relatively long elimination half-life (74.1 h) and a mean residence time of 97.6 h after a single intramuscular administration...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29029051/multi-locus-sequence-typing-and-virulence-genotyping-of-streptococcus-suis-serotype-9-isolates-revealed-high-genetic-and-virulence-diversity
#6
Wenyang Dong, Yinchu Zhu, Ye Ma, Jiale Ma, Yue Zhang, Lvfeng Yuan, Zihao Pan, Zongfu Wu, Huochun Yao
Streptococcus suis (S. suis) is an important swine pathogen that can cause a variety of diseases. S. suis serotype 9 (SS9) is a prevalent serotype, but limited information is available. Here, we studied and compared 30 SS9 isolates, including 24 isolates from China between year 2004 and 2013, 5 isolates from Vietnam and a serotype reference isolate from Denmark. A MLST analysis was performed to exploit the genetic relationships between those isolates. The phylogenetic tree based on the MLST data divides those isolates into two clades (I and II), revealing different evolutionary paths of collected strains...
September 22, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29026620/streptococcus-suis-serotype-9-endocarditis-and-subsequent-severe-meningitis-in-a-growing-pig-despite-specific-bactericidal-humoral-immunity
#7
Karoline Rieckmann, Kristin Müller, Annette Moter, Christoph G Baums, Anna Seydel
INTRODUCTION: . Meningitis and endocarditis are common pathologies of Streptococcussuis infections in pigs and humans. S. suis serotype 9 strains contribute substantially to health problems in European pig production, and immune prophylaxis against this serotype is very difficult. CASE PRESENTATION: . We report the clinical course and histopathological picture of a 10-week-old growing pig following experimental intravenous infection with S. suis serotype 9. The piglet showed rapid onset of severe clinical signs of meningitis 11 days post-intravenous challenge following prime-booster vaccination...
May 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29024714/antibacterial-effect-and-bond-strength-of-a-modified-dental-adhesive-containing-the-peptide-nisin
#8
Meixuan Su, Shunyi Yao, Lisha Gu, Zihua Huang, Sui Mai
This study attempted to incorporate the antibacterial peptide nisin into an etch-and-rinse dental adhesive to evaluate the antibacterial activity of the modified adhesive against Streptococcus mutans and the bond strength. Single Bond 2 was used as a negative control, and nisin was incorporated at 1%, 3%, and 5% (w/v). The antibacterial activity against S. mutans was evaluated using the film contact test, the agar diffusion test, XTT assays and confocal laser scanning microscopy (CLSM). The microtensile bond strength (μTBS) of the modified dental adhesive was also evaluated...
October 9, 2017: Peptides
https://www.readbyqxmd.com/read/29022552/multiplex-pcr-for-identification-of-six-clinically-relevant-streptococci
#9
Rujirat Hatrongjit, Yukihiro Akeda, Shigeyuki Hamada, Marcelo Gottschalk, Anusak Kerdsin
PURPOSE: The aim of this study was to develop a multiplex PCR (mPCR) for simultaneous detection (single reaction) of six clinically relevant streptococcal species: Streptococcus pneumoniae, Streptococcus suis, Streptococcus gallolyticus subsp. gallolyticus, S. gallolyticus subsp. pasteurianus, Streptococcus intermedius and Streptococcus anginosus/constellatus. METHODS: mPCR with primers specific for S. pneumoniae (lytA), S. suis (recN), S. gallolyticus subsp. gallolyticus (tanB), S...
October 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29022550/streptococcus-gordonii-pheromone-s-g-cam373-may-influence-the-reservoir-of-antibiotic-resistance-determinants-of-enterococcus-faecalis-origin-in-the-oral-metagenome
#10
Jillian M Mansfield, Paul Herrmann, Amy M Jesionowski, M Margaret Vickerman
Streptococcus gordonii produces a pheromone heptapeptide, s.g.cAM373, which induces a conjugative mating response in Enterococcus faecalis cells carrying the responsive plasmid, pAM373. We investigated the extent of this intergeneric signaling on DNA acquisition by streptococcal species likely to cohabit oral biofilms. E. faecalis/pAM373/pAMS470 cells were incubated with synthetic s.g.cAM373, reverse peptide s.g.cAM373-R, or peptide-free medium and examined for their abilities to transfer plasmid DNA to streptococcal species in the presence of DNase...
October 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28980519/exploring-target-specific-primer-extension-in-combination-with-a-bead-based-suspension-array-for-multiplexed-detection-and-typing-using-streptococcus-suis-as-a-model-pathogen
#11
Fimme J van der Wal, René P Achterberg, Conny van Solt-Smits, Jan H W Bergervoet, Marjanne de Weerdt, Henk J Wisselink
We investigated the feasibility of an assay based on target-specific primer extension, combined with a suspension array, for the multiplexed detection and typing of a veterinary pathogen in animal samples, using Streptococcus suis as a model pathogen. A procedure was established for simultaneous detection of 6 S. suis targets in pig tonsil samples (i.e., 4 genes associated with serotype 1, 2, 7, or 9, the generic S. suis glutamate dehydrogenase gene [ gdh], and the gene encoding the extracellular protein factor [ epf])...
October 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28970042/long-term-outcomes-of-patients-with-streptococcus-suis-infection-in-viet-nam-a-case-control-study
#12
Vu T L Huong, Hoang B Long, Nguyen V Kinh, Ta T D Ngan, Vu T V Dung, Behzad Nadjm, H Rogier van Doorn, Ngo T Hoa, Peter Horby, Heiman F L Wertheim
OBJECTIVES: Streptococcus suis is a zoonotic cause of severe meningitis and sepsis in humans. We aimed to assess the long-term outcomes in patients who survived S. suis infection, in particular the progress and impact of vestibulocochlear sequelae. METHODS: This case-control study evaluated outcomes of S. suis infection at discharge and 3 and 9 months post-discharge for 47 prospectively enrolled cases and at 11-34 months for 31 retrospectively enrolled cases. Outcomes in patients were compared to 270 controls matched for age, sex and residency...
September 29, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28953248/effect-of-simultaneous-exposure-of-pigs-to-streptococcus-suis-serotypes-2-and-9-on-their-colonization-and-transmission-and-on-mortality
#13
Niels Dekker, Annemarie Bouma, Ineke Daemen, Hans Vernooij, Leo van Leengoed, Jaap A Wagenaar, Arjan Stegeman
The distribution of Streptococcus suis serotypes isolated from clinically infected pigs differs between geographical areas, and varies over time. In several European countries, predomination of serotype 2 has changed to serotype 9. We hypothesize a relation, with one serotype affecting the other in colonization and invasion. The aim of this study was to evaluate whether simultaneous exposure of pigs to serotypes 2 and 9 affects colonization and transmission of each type, and mortality. Thirty-six caesarean-derived/colostrum-deprived piglets were randomly assigned to three groups, and there housed pair-wise...
September 27, 2017: Pathogens
https://www.readbyqxmd.com/read/28939359/streptococcus-suis-meningitis-can-require-a-prolonged-treatment-course
#14
Jean Dejace, Patrick Bagley, Emily Wood
We report a case of recrudescent Streptococcus suis meningitis requiring a prolonged treatment course. A few similar cases can be found in the burgeoning literature on what remains a relatively uncommon disease in humans, and these patients should be monitored carefully upon completion of therapy.
September 20, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28932685/pig-s-ear-streptococcus-suis-meningitis-and-its-associated-inner-ear-implications
#15
S Sena Esteves, J Carvalho de Almeida, J Abrunhosa, C Almeida E Sousa, Q Arshad
Streptococcus suis (S. suis) is a zoonotic pathogen commonly found in Asian countries. Infection with this bacterium typically clinically presents as meningitis and individuals whom handle swine are at increased risk of developing infections. We present a case of a patient with a S. suis meningitis who worked as a butcher. The 48-year-old man was admitted to our department with headaches, fevers, nausea and bilateral hearing loss. According to his medical history, the patient had sustained a cut on his finger while preparing pork meat...
2017: IDCases
https://www.readbyqxmd.com/read/28924148/investigation-of-the-inhibition-effect-and-mechanism-of-myricetin-to-suilysin-by-molecular-modeling
#16
Xiaodi Niu, Lin Sun, Guizhen Wang, Yawen Gao, Yanan Yang, Xiyan Wang, Hongsu Wang
In the present study, the inhibitory effect and mechanism of myricetin, a natural flavonoid compound, in relation to Suilysin (SLY) were investigated through molecular dynamics simulations, mutational analysis and fluorescence-quenching assays. Myricetin is a potential inhibitor that does not exhibit antimicrobial activity but has been shown to inhibit SLY cytotoxicity. Molecular dynamics simulations and mutational analysis revealed that myricetin binds directly to SLY in the gap between domains 2 and 3, an important region for oligomerization and pore formation...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28902637/development-of-fish-collagen-bioactive-glass-chitosan-composite-nanofibers-as-a-gtr-gbr-membrane-for-inducing-periodontal-tissue-regeneration
#17
Tian Zhou, Xin Liu, Baiyan Sui, Chao Liu, Xiumei Mo, Jiao Sun
The development of a guided tissue or bone regeneration (GTR/GBR) membrane with excellent performance has been a major challenge in the biomedical field. The present study was designed to prepare a biomimetic electrospun fish collagen/bioactive glass/chitosan (Col/BG/CS) composite nanofiber membrane and determine its structure, mechanical property, antibacterial activity, and biological effects on human periodontal ligament cells (HPDLCs). The effects of this composite membrane on inducing periodontal tissue regeneration were evaluated using a dog class II furcation defect model...
September 13, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28894449/type-i-interferon-induced-by-streptococcus-suis-serotype-2-is-strain-dependent-and-may-be-beneficial-for-host-survival
#18
Jean-Philippe Auger, Agustina Santinón, David Roy, Karen Mossman, Jianguo Xu, Mariela Segura, Marcelo Gottschalk
Streptococcus suis serotype 2 is an important porcine bacterial pathogen and emerging zoonotic agent mainly responsible for sudden death, septic shock, and meningitis, with exacerbated inflammation being a hallmark of the infection. However, serotype 2 strains are genotypically and phenotypically heterogeneous, being composed of a multitude of sequence types (STs) whose virulence greatly varies: the virulent ST1 (Eurasia), highly virulent ST7 (responsible for the human outbreaks in China), and intermediate virulent ST25 (North America) are the most important worldwide...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28888647/fibronectin-fibrinogen-binding-protein-fbps-is-not-a-critical-virulence-factor-for-the-streptococcus-suis-serotype-2-strain-zy05719
#19
Quan Li, Yang Fu, Yanan He, Yuhang Zhang, Yunyun Qian, Yanfei Yu, Huochun Yao, Chengping Lu, Wei Zhang
Fibronectin-/fibrinogen-binding protein (FBPS) of Streptococcus suis serotype 2 (SS2) is an atypical anchorless microbial surface components recognizing adhesive matrix molecules (MSCRAMM) for which the role in bacterial infection are not clearly established. To investigate the biological functions of FBPS, an fbps knockout mutant was constructed in SS2 strain ZY05719 to explore the phenotypic changes between the wild-type and mutant strains. Cell morphology analyses combined with the basic growth curves showed that deletion of fbps does not significantly influence neither the thickness of the capsule of SS2 nor the cell growth characteristic...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28865219/expression-and-immunological-evaluation-of-elongation-factor-tu-of-streptococcus-suis-serotype-2
#20
X J Xia, L Wang, L K Cheng, Z Q Shen, S G Li, J L Wang
Streptococcus suis serotype 2 (SS2) is considered as a major pathogen that causes sepsis and meningitis in piglets and humans, but knowledge of its antigenic proteins remains limited so far. The surface-related proteins of pathogens often play significant roles in bacterium-host interactions and infection. Here, we obtained the elongation factor Tu (EF-Tu) gene of Streptococcus suis and constructed the recombinant expression plasmid successfully. The target recombinant plasmid was then expressed in Escherichia coli and the immuno-protection of the recombinant protein was subsequently evaluated as well...
March 1, 2017: Polish Journal of Veterinary Sciences
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